(Continued from page 1214)Great Scientists of Old as Heretics In "The Scien-

tific Method." C. Truesdell. University Press of Virgin-ia, Charlottesville, VA, 1987. vi, 96 pp., illus. $19.95.Based on lectures, 1985.

Illustrating Pascal. Donald Alcock. Cambridge Uni-versity Press, New York, 1987. viii, 184 pp., illus. Spiralboupd, $12.95.Immunologle de la Reproduction: Relation Ma-

temo-Foetale. Reproductive Immunology: Materno-Fetal Relationship. Gerard Chaouat, Ed. Editions del'Institut Nationa de la Sante et de la Recherche Medi-cale, Paris, 1987. xiv, 483 pp., illus. F 250. ColloqueINSERM, vol. 154. From a symposium, Paris, France,Dec. 1986.Immunopharmacology of Infectious Diseases.

Vaccine Adjuvants and Modulators of Non-SpecificResistance. Jeannine A. Majde, Ed. Liss, New York,1987. xxiv, 359 pp., illus. $68. Progress in LeukocyteBiology, vol. 6. From a symposium, Columbia, MD,June-July 1986.

Innovative Tracks at Established Institutions forthe Education of Health Personnel. An ExperimentalApproach to Change Relevant to Health Needs. MartinKantrowitz et al. World Health Organization, Geneva,1987. 232 pp., illus. Paper, $23.40. WHO Offset Publi-cation no. 101. Based on a meeting, Albuquerque, NM,Oct. 1986.

Insects and Human Society. AVI (Van NostrandReinhold), New York, 1987. xiv, 450 pp., illus. $39.95.

Inside Relativity. Delo E. Mook and Thomas Var-gish. Princton University Press, Princeton, NJ, 1987.xiv, 306 pp., illus. $30.

Integration, Coordination and Control of Multi-Sensor Robot Systems. Hugh F. Durrant-Whyte.Kluwer, Norwell, MA, 1987. xx, 236 pp., illus. $45.Kluwer International Series in Engineering and Comput-er Science, vol. 36.

Integrative Neuroendocrinology. Molecular, Cellu-lar and Clinical Aspects. S. M. McCann and R. I. Weiner,Eds. Karger, BaseL, 1987. viii, 243 pp., illus. $120. Froma congress, San Francisco, CA, July 1986.

Literacy. Reading the Word and the World. PauloFreire and Donaldo Macedo. Bergin and Garvey, SouthHadley, MA, 1987. xxiv, 184 pp. $34.95; paper, $12.95.Critical Studies in Education Series.The Material Culture of the Chumash Interaction

Sphere. Vol. 5, Manufactuing Processes, Metrology,and Trade. Travis Hudson and Thomas C. Blackburn.Ballena, Menlo Park, CA, and Santa Barbara Museum ofNatural History, Santa Barbara, CA, 1987. 358 pp.,illus. $41.95; paper, $28.95. Ballena Press Anthropolog-ical Papers, no. 31.

Nutritional Bloavailability of Manganese. Con-stance Kies, Ed. American Chemical Society, Washing-ton, DC, 1987. x, 155 pp., illus. $39.95. ACS Sympo-sium Series, 354. Based on a symposium, Anaheim, CA,Sept. 1986.Pattems of Birthwelghts. Ruth Rice Puffer and

Carlos V. Serrano. Pan American Health Organization,Washington, DC, 1987. xiv, 109 pp., illus. Paper, $10.Scientific Publication no. 504.The Quickening Universe. Cosmic Evolution and

Human Destiny. Eugene F. Mallove. St. Martin's, NewYork, 1987. xx, 268 pp., illus. $16.95. A Thomas DunneBook.Receptor-Receptor Interactions. A New Intra-

membrane Integrative Mechanism. Kjell Fuxe and LuigiF. Agnati, Eds. Plenum, New York, 1987. xviii, 561 pp.,illus. $85. Wenner-Gren Intemational Symposium Se-ries, vol. 48. From a symposium, Stockholm, Oct. 1986.Thermophysical Propertis of Neon, Argon,

Krypton, and Xenon. V. A. Rabinovich et al. TheodoreB. Selover, Jr., English-language edition editor. Hemi-sphere (Harper and Row), New York, 1987. xviii, 604pp., illus. $150. National Standard Reference Data Ser-vice of the USSR, vol. 10. Translated from the Russianedition (Moscow, 1976).Twelfth International Seaweed Symposium. (Sao

Paulo, Brazil, July-Aug. 1986.) Mark A. Ragan andCarolyn J. Bird, Eds. Junk, Dordrecht, 1987 (U.S.distributor, Kluwer, Norwell, MA). xxviii, 590 pp., illus.$182.50. Developments in Hydrobiology, 41.

Universe. William J. Kauflnann, III. 2nd ed. Free-man, New York, 1988. xxii, 634 pp., illus. $36.95.

User-Oriented Computer Languages. Analysis andDesign. Melvin Klerer. Macmillan, New York, 1987. xvi,208 pp. $34.95. Macmillan Database/Data Communica-tions Series.

Vectors. A Survey of Molecular Cloning Vectors andTheir Uses. Raymond L. Rodriguez and David T.Denhardt, Eds. Butterworths, Stoneham, MA, 1987.xiv, 578 pp., illus. $54.95. Biotechnology.

I228

PersonnelPlacement

SCIENCE publishes each Friday, except the last Fridayof the year. Advertising is accepted only in writing; noabbreviations. Any deadline in ad must be at least 2weeks after date of issue in which ad appears. Also,personnel advertising is accepted only with the under-standing that the advertiser does not discriminateamong applicants on the basis of race, sex, religion,age, color, national origin, handicap, or sexual prefer-ence. SCIENCE reserves the right, in its discretion, todecline to publish advertisements submitted to it.

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POSITIONS WANTED

Aquatic Biologist, recent Ph.D. seeks postdoctoral ortemporary research position. Has extensive experience invarious aspects ofculturing and bioassay ofdaphnids andalgae. Box 80, SCIENCE.

Aquatic Toxicologist. Ph.D. seeking position in indus-trial/consulting sector. Extensive academic and profes-sional experience. Knowledgeable in FIFRA, TSCA, andFDA GLP's and testing guidelines. Box 81, SCIENCE.

fliochemist, Ph.D. Principal investigator with 13-yearacademic expenence in life sciences induding monodonalantibodies, histochemistry, immunochemistry, protein pu-rification, enzymology, phosphoinositides, computer anal-ysis. Proven grant and publication record. Seeking respon-sible academic or industrial position in Baltimore-Washing-ton-Wilmington area. Box 83, SCIENCE.

POSITIONS WANTED

Bologist/Zoolgist, Ph.D. with broad academic training17 years of teaching expenence all levels/field. Biology mUSA and Africa; extensive publications seeking teaciingand/or research position. Box 84, SCIENCE.B.S. in chemistry, 10 years industrial organic and analyti-cal expenrence seeks permanent assignment writing tech-nical software. Box 85, SCIENCE.

Foreign Pharmacologist. Ph.D. Classical pharmacologytrang. Broad research experience in autonomic andsystemic pharmacology. Experienced visiting scientist.Curriculum vitae, 8 years of undergraduate and post-graduate teaching. Good scientific editor. Good interper-sonal and communication skills. Seeks academic research/teaching or industrial research opportunities. Box 86,SCIE CE.

Immunologist, Ph.D. Research and development scien-tist with extensive background in hybridomas, monoclo-nal antibodies, targeted chemotherapy in cancer, andlarge-scale tissue culture, seeks group leader/project di-rector position in academic/industrial laboratory. Out-standing worker with excellent credentials. Box 74,SCIENCE.

M.S. Biochenistry and Organic Chemistry and over18 years ofacademic and industrial research experience inproduction and characterization ofmonoclonal and poly-lonal antibodies, RIA and ELISA analysis of proteinsand haptens, enzymology, pharmacology, analyticalmethods development, publications. Telephone: 215-968-0483 after 6 p.m. EST. Box 75, SCIENCE.

Rctrovirologist, Ph.D. AIDS researcher with publica-tions and experience in virology/cell biology, antiviralagents and some molecular biology. Currently interestedin the diversity of HIV-1 isolates vcrsus pathogenesis.Seeks academic/industrial position in Washington, D.C.area. Box 87, SCIENCE.

Scicntific Data Analysis and Presentation. Semi-re-tired Ph.D. (physiology), with over 30 years of experi-ence developing and program g both routine andnovel analysis methods; many refereed publications.Lower rates for interesting projects. Box 65, SCIENCE.

POSITIONS OPEN

ASSISTANT PROFESSOR-The Department ofChemistry and Biochemistry and the Center for Agricul-tural Biotechnology of the University of Maryland,College Park announce the opening of a tenure-trackjoint assistant professorship. The successful candidatewill be expected to initiate a competitive research pro-gram in the area of plant biochemustry, and to establishan interface between the Department and the Center.Investigators whose research interests include the bio-physical and/or enzymological aspects of plant biochem-istry are especially encouraged to apply. The joint ap-pointee will Have modem laboratory space in chemistryand biochemistry, a one-half teaching load and filll accessto departmental facilities and graduate students. A resu-

,a synopsis of research interests, and three letters ofrecommendation should be sent by 15 August 1988 to:John W. Kozarich, Center for Agricultural Biotech-nology, H. J. Patterson Hall, Univcrsity ofMaryland,College Park, MD 20742. The University ofMaryland isan Equal Opportunity Emplyer.American University, ASSISTANT PROFESSOR,

PHYSICAL BIOCHEMISTRY. A tenture-track posi-tion is available for academic year 1988 to 1989, begin-ning fall 1988, at The American University in Washmg-ton, D.C. Responsibilities include teaching undergradu-ate and graduate physical chemistry, establishing anexternally funded research program in biochemistry,scholarship student advising and University service.Qualifications: Ph.D. required, postdoctoral experiencepreferred. Applicants should submit curriculum vitae,outline of research interests, a list of publications, andthree letters of reference to: Dr. James E. Girard,Chairman, Department of Chemistry, The AmericanUnivcrsity, 4400 Massachusetts Avenue, NW, Wash-ington, DC 20016. Applications received by 15 June1988 are assured of full consideration. The AmericanUniersity is an Equal Employment Opportunity/AffimativeAction Univesity; minority and women candidates areencouraged to apply.

SCIENCE, VOL. 240

POSITIONS OPEN

University of Michigan Medical School, Departmentof Biological Chemistry, is inviting applications for afaculty position at the rank ofASSISTANT PROFES-SOR. Candidates should have a Ph.D. in organic chemis-try with postdoctoral training in the isolation and charac-terization of mammalian cytochrome P-450 and relatedenzymes, protein chemistry, and use of techniques suchas GC and HPLC. A strong interest and publications inthe area of enzyme reaction mechanisms is necessary.Teaching obligations will not exceed 5 to 10% of totaleffort. Send rvsume to: Dr. M. J. Coon, Chairman,Department of Biological Chemistry, The UniversityofMichigan Medical School, Ann Arbor, MI 48109-0606. A nondiscnininatory, Affirmative Action Employer.Code 41.

ASSISTANT PROFESSORThe Institute for Advanced Studies in Biological Pro-

cess Technology in the College of Biological Sciences ofthe University of Minnesota invites applications for atenure-track position at the rank of assistant professor ofgenetics and cell biology or microbiology.

Applicants must have a Ph.D. in either microbiology,genetics, biochemistry or a related field. We are seekingan individual whose research interests are directly relatedto the genetics, physiology or metabolism of microorga-nisms. Individuals with an interest in the streptomycesare encouraged to apply. Applicants must have a mini-mum of 2 years of postdoctoral training, demonstratedresearch ability and the potential to develop an activeindependent research program. Preference will be givento individuals who have an interest in application of theirresearch to biotechnology.Tenure and teaching responsibilities for this position

will reside in the Department of Genetics and CellBiology or the Department of Microbiology. This posi-tion is available beginning in the fall of 1988. Salary isnegotiable based upon applicants previous experience.

Applicants should send a letter summarizing theirresearch interests, experience, and goals; curriculum vi-tae; relevant reprints of recent research; and have threeletters of recommendation sent to: Dr. Michacl C.Flickiner, Director, Institute for Advanced Studiesin Biological Process Technology, 240 Gortner Labo-atories, 1479 Gortner Avenue, University ofMinne-sota, St. Paul, MN 55108.

Applications should be postmarked no later than 31July 1988.

The University of Minnesota is an Equal OpportunityEducator and Employer and spectfiway invites and encour-ages applicaionsfom womcn and minoritis.

ASSISTANT PROFESSOR OF PHARMACOL-OGY-DRUG ABUSE RESEARCH. The Depart-ment of Pharmacology and Toxicology at the Universityof Arkansas for Medical Sciences anticipates one, orpossibly two, openings late in. 1988. The successfulapplicants will have a joint appointment in the Depart-ment and in the new Center for Alcohol and Drug AbuseResearch. Applicants with two or more years of postdoc-toral research experience in the molecular aspects ofdrugabuse or alcoholism are preferred, although investigatorswith strong accomplishments in other areas of substanceabuse research will be considered. Interested applicantsshould submit curriculum vitae to: Dr. Donald E.McMillan, Professor and Chairman, Department ofPharmacology and Toxicology, University of Arkan-sas for Medical Sciences, 4301 West Markham Street,Mail Slot 611, Little Rock, AR 72205.

UNIVERSITY OF MINNESOTA, MORRISOne-year sabbatical replacement faculty position in

geology, ASSISTANT PROFESSOR OR IN-STRIUCTOR level beginning 16 September 1988. Areaof specialization must be paleontology and sedimentol-ogy. Participation in teaching physical geology andintroductory field methods courses is required. Collegelevel teaching as a graduate teaching assistant or closelvrelated expenence required. M.S. in geology require,Ph.D./Ph.D. candidate desired. Discipline offers B.A.degree in geology and earth science education. Salaryopen and competitive with academic institutions. Sendrsume, transcripts, three letters of reference by 17 June1988: Dr. James M. Olson, Chair, Room 217, Scienceand Mathematics Division, University of Minnesota,Morris, Morris, MN 56267. Te Un ofMinnesoa,Momi is an Equal Opptunity Edor and E er andseafwally intes and encourages appicatiom women andmin e.

ASSISTANT PROFESSOR OFPHARMACOLOGY

The Department of Pharmacology, University of Cali-fornia, Los Angeles (UCLA) seeks an individual to teachand conduct research in drug metabolism, pharmacoki-nctics and toxicology. The successful candidate will havea strong background in chemistry, the ability to establisha strong and independent research program and toeffectively teach graduate and medical students. Pleasesend curriculum vitae, bibliography, summary ofprofes-sional accomplishments and goals, together with thenames of three references to: Cha, Search Comiittee,UCLA Medical Centcr, Department of Pharmacolo-gy, 10833 Le Conte Avenuc, Los Angeles, CA90024-1735. The Univerrity of Califrnia is an EqualOpportunitylAffirmativeAction Employer.

ASSISTANT PROFESSOR(TENURE-TRACK)

CLINICAL MICROBIOLOGY LABORATORYDEPARTMENT OF LABORATORYMEDICINE AND PATHOLOGYUNIVERSITY OF MINNESOTA

A tenure-track faculty position is available for candidateswith an M.D. degree with subspecialty training in labora-tory medicine/patholgy or infectious diseases with a mini-mum of 3 years of postdoctoral expenence or research inclinical microbiology or microbial pathogenesignetics.Competence in current molecular technology is desirable.Demonstration of research productivity is necessary, in-dudig publications in peer-reviewed joumals.The individual will be expected to contribute to Clini-

cal Microbiology Laboratory services, development ofnew diagnostic tools, and the teaching of postgraduateresidents and postdoctoral fellows. The individual will beexpected to develop an independent research program.

Applicants should send curriculum vitae and threeletters of recommendation to: Chairperson, ClinicalMicrobiology Search Committee, University of Min-nesota, Box 198 UMHC, Department of LaboratoryMedicine and Pathology, 420 Delaware Street S.E.,Minneapolis, MN.

Deadfine for receipt of applications is 15 November1988. The Universiy ofMinnesota is an Equal OpportunityEducor and Employer and specifically invites and encour-ages applicationfrom women and minorities.

THE SALK INSTITUTEASSISTANT/ASSOCIATE PROFESSOR

The Salk Institute Molecular Biology and VirologyLaboratory (MBVL) is seeking candidates to undertakeindependent research in molecular genetics and develop-ment. Current areas of research in MBVL include:oncogenic proteins and cell transformation (W. Eck-hart); steroid receptors, neuroendocrine genes and devel-opment in transgenic mice (R. Evans); protein phospho-rylation and signal transduction (T. Hunter); transcrip-tion factors (K Jones); sexual differentiation in Drosophi-la (M. McKeown); protein tyrosine kinases (B. Sefton);oncogenes and gene therapy (I. Verma); immnortaliza-tion and transformation (M. Vogt); and gene amplifica-tion and DNA replication (G. Wahl). The Salk Instituteoffers a highly interactive cnvironment, with a number ofresearch groups working in areas of molecular biologyand the neurosciences. The institute is in close proximityto several major research institutions.

Interested individuals may submit an application to:MBVL Search Committcc, P.O. Box 85800, SanDiego, CA 92138. Please include curriculum vitae, abrief description of present and future scientific endeav-ors, and names of references.The Salk Institute is an Equal Opportunity Employer,

M/FIHIV.ASSISTANTORASSOCIATE PROFESSOROF

MEDICINE to assume major scientific responsibilityfor a cardiovascular molecular biology program. Thecandidate may be an M.D. or Ph.D. with interest andexperience in molecular genetics of contractile proteins,membrane channels or membrane receptors. The candi-date would be expected to establish own laboratory andinteract dosely with active ongoing laboratories workingin biochemistry, cell physiology, and cell biology of thecardiovascular system within a research-oriented Sectionof Cardiology. Please send inquiries, resume, and thenames of three references to: Morton F. Arnsdorf,M.D., Chief, Section of Cardiology, University ofChicago Hospitals, Box #423, 5841 South Mary-a hicago, IL 60637.

ASSISTANT, ASSOCIATE, ORPROFESSOR OF PLANT PATHOLOGY

The Department of Plant Pathology, University ofCalifornia, Berkeley announces a 9-month tenure-trackassistant, associate, or full professor position in plantpathogenic fungi, effective 1 January 1989. Applicantsmust have a Ph.D. degree with at least 2 years ofpostdoctoral experience in an area appropriate to thedescribed position. Examples of research areas thatwould be considered appropriate include: the molecularbiology of a choice of plant pathogenic funi includingpathogens of forest trees and/or cultivated crop plants,the molecular genetics and biology ofinfection or diseaseresistance processes or the molecular basis of pathogen-host specificity. Teaching responsibilities wil includeresponsibility for portions of an introductory graduateclass on biology, physiology, genetics, and molecularbiology of plant pathogenic fungi and a graduate coursein molecular plant pathology and the development of anadvanced seminar. Applicants should submit curriculumvitae, transcipts, publications, and a brief description ofresearch goals, and arrange for three letters of referenceto be sent to: J. G. Hancock, Department of PlantPathology, University of California, Berkeley, CA94720, by 1 September 1988. The Univesity ofCalifoniais an Equal OpportunitylAffirmatie Action Employer.

BIOTECHNOLOGY STORY WRITERSA new genetic engineering quarterly magazine is look-

ing for free-lance writers with rDNA (or related) experi-ence and journalism backgrounds for feature articles onthe biotechnology industry and latest technology. Workfrom your present location. Macintosh computer usersare preferred. Candidates should submit applicationswith credits and samples to: G. Kawasaki, Editor, 1858Swan Cirdc, Costa Mesa, CA 92626.

CELL BIOLOGY/BIOCHEMISTRY: VISITINGASSISTANT/ASSOCIATE PROFESSOR for up to3-year appointment to teach cell biology and biochemis-try and assist in introductory biology majors coursebeginning January 1989. Ph.D. required. Active researchprogram and involvement of undergraduates encour-aged. The Department of Natural Sciences is a multi-disciplinary department which offers B.S. degrees inbiological sciences, chemistry, physics, microbiology,environmental science, biochenistry, and general sci-ence. Send curriculum vitae and names of three refer-ences to: Biology Search Secretary, Department ofNatural Scicnces, The University ofbom, Dearborn, MI 48128-1491. Application screen-ing will begin 15 June 1988. The University ofMichan-Dearborn is an Equal Opportunity Educator and Employerand specifically invites and encouragcs applicatons fromwomcn and minorities.

CHAIRPERSON, DEPARTMENT OF PHYSI-OLOGYAND BIOPHYSICS: The University ofMis-sissippi Medical Center invites nominations for the posi-tion of professor and chairperson of the Department ofPhysiology and Biophysics. Candidates should have ex-tensive teaching experience and be established investiga-tors with a record of scholarly contributions and partici-pation in appropriate professional organizations. Candi-dates with administrative background are preferred. TheMedical Center in Jackson is Mississippi's only academichealth center. There are four health professional schoolson the campus-Schools of Medicine, Nursing, HealthRelated Professions and Dentistry; graduate programs inthe medical sciences; and the 541-bed University Hospi-tal, teaching hospital for all programs. The Departmentof Physiology and Biophysics has campuswide teachingresponsibilities. The department is particularly noted forits research in cardiovascular, renal and endocrine physi-ology and for its quantitative approach to physiology,especially in the application of control systems analysisand computer simulation of physiological mechanisms.There are also active research programs in the areas ofcellular, respiratory and neurophysiology. Nominationsfor the position should include the nominee's name,curriculum vitae, and names and telephone numbers ofthree references, and should be addressed to: I. K. Ho,Ph.D., Chairnan, Search Committee, c/o the Dcpart-ment ofPharmacology and Toxicology, the Universi-q of Mississippi Medical Center, 2500 North StateStreet, Jackson, MI 39216-4505. Application dead-line is 1 August 1988.

PERSONNEL PLACEMENT 122927 MAY I988

POSITIONS OPEN POSITIONS OPEN

NPOSITIONS OPEN

COUNTY DIRECTOR/ADVISOR (Headquar-ters: Marin County): The University ofCalifomia (TC),Division of Agriculture and Nat Resources, Cooper-ative Extension (CE) is seeking a career-track academiccandidate who is responsible to the CE North CentralRcgional Director for operation and conduct of the CEprogram in Marin County. Sce that effective educationaland research programs are carried out; direct the person-nel administrtion of county Extension sta£, maintaineffectivc communications within the organizaion; secureadequate county Extension budget fmnding; develop/maintain good working rclationships with various public/private organizations within the county. Responsibleto the Main County Board of Supervisor and theCounty Administrator for the county budget process. Aminimum of Master's degree or equivalent combinationof education and experinecc in agricultural sciences and/or Extension related fields is required. Demonstratedexpeince in county extension academic position in anagricultural-urban county is desired. An understandingof basic CE.programs, inuding aiculture, family andconsumer science, 4-H youth, development and commu-nity resource develpment is essentiaL. Assure affirmativeaction in development and delivery of programs. Salarywill be commensurate with eience and professionalqualifications. For complet description, contact: UCDivisn of Agricultural and Natural Reources Per-sonnl, 6h Flor, Kaisr Center, 300 Lakeside Drive,Okand, CA 94612-3560. Telephone: 415-987-0088. Closc: 17 June 1988. Refcr to #A-88-061. Af-finxativeAationlEqu Oppornity EmoployerMFIH.ENVIRONMENAL TOXICOLOAGIST-cart-

mmt of Biologkal Sciences at the University of NorthTexas (UNT)invie applcations for a tenure-trac assist-ant/associate/fii prsor positom A PhD. or equivalentdegree and an outnding roord of research and publica-tion isrequid Successful candidates will be expected todevelo*/maintain a vigoros, grant supported rcsearchp am, to a inWaduatand greaing, to dirct M.S. and Ph.D. students and to diecthe Aquatic Toxicogy Labatory. Univeity of NorthTeams is an emeging nationl research insitutim in thevibrt and rad ead1ingg Dallas-Fort Worth metr-politan area wiovr 00 regular faculy and aver 22,000smdcnts (one-dtiW dt students). Submit crriculmvke,dxitm FMscx arh. ir and narnes o!f the

refeene by 30 June 1988 to: KYnneh L. Dickson,De ent of Biological SSdences, P.O. Box 13078,Uni ity of North Texs, D ton, [X 76203-3078.UNT it anAf natvActAaionEql Oppotwnity Employer.

EVOLUTIONARY BIOLOGIMThe National Zoological Park, Smithsonian Institu-

tion, is seeking two evolutionary biologists, a seniorscitist-in-charge, and research scientist Candidatesmust be interested in conservation biology and capabk ofusing molcular techniques towards the analysis Of opu-lation genetics and sociobiological problems in hXigervertebrates (especialy birds and mammals). Both candi-dates shouid havc active research programs and demon-strated research productivity. Additional dutics of thesenior position inchlde oversoeng thc zoo's moleculargenetics unit, maneging a molecular genetics laboratory,and superisig junior staff, technicians, research fellows,

auccssful candidatc for both positions willbe expected to devcop independent research programsand undertake collaborativc research with zoo staffwhose interems inchldc the genetics of natural and wildopulations, population mana nicnt, physiolg, be-

ecology, and sociobiology. Salarics and gradekvels will be commensurate with education and/or cxpe-rinec, and are likely to range from GS-12 to GS-15.

Start-up and operating fnds for the laboratory areexpeted, but the sucessfull candidates will be cxpectedto generate grant funds to support somc of the research.Applications must include an SF-171 (personal qualifica-tions statement), college/university transcipts, curncu-lum vitae, descrption of research and career goals,abstracts ofyour thre most significant publications, andnames and addresses of three referenes; and should beaddressed to: Smithonia Institon EmplymentOffice, 900 Jeffrson Drive, S.W., Wa DC20560. A separate applicat is required for eac posi-tion Deadline is 30 June 1988. Address inquiries to: Dr.D. G. Klciman, National Zooloc Pa, Wasing-ton, DC 20008. The S sonian Insti ia Eqa0ptunipbyc. A tplinpti aCd

DEAN OF FACULTYTHE SCHOOL FOR FIELD STUDIES

The School for Field Studies (SFS) is the leadingintenational propam ofering courseworkand field research in conservation biology at ficld sitesthroughout the world. Annual student enrollment,700+.The Dean of Faculty is responsible for the academic

program developmcnt and scientific rsarch direction ofthe School. Dcan will supervise four Centers (Kenya,Austalia, Mexico, Caribbean), twelve faculty, thirtypart-time faculty and support staff.

Requirements: Ph.D., preferably in conservation biol-ogy, resource management or related discipline. Candi-datc must have sificant experience in educationaladminisration, fiel work (preferably overscas), and inteaching and research. Candidate must also exhibit acommmimtm to nontraditional education and be readyfor the challnge of directing a rapidly cxpanding educa-tional program.

Salary: $50,000 to $60,000 plus benefits. Send curric-ulum vite and ltter ofrecommedation to: PresidentsOffice, SFS, 376 Hale Street, Bcverly, MA 01915.AnEqual Opportunity Eployer.

ELECTROCHEMISTSEastem manufacturer of battcry systems and ectro-

chneical gas sensing devices seeks B.S., M.S., or Ph.D.lectrochemical, elctroanalytical, or anlytical degreewith or without work experience. US citi p orperma-xnet reidency required. Submit resume to: Box 82,SCIENCE.

UNIVERSITY OF CALIFORNIABERLEY

COLLEGE OF NATURAL RESOURCESFACULTY AND AGRICULTURAL EXPERI-

MENT ST7ATION POSITION in the Division ofBiolgical Control and Deparmet of EntomologicalSciences. A tenure-track posiLtion as assisant professor ofentomoogy and entomologist in the Experirmnt Stationwill be availabc 1 Scptember 1988. This is a 9-monthappointment with summer salary guaranteed to tenure.Qlifications must include a Ph.D. degree in entomolo-gy or a related field Demonstrated skills in statistics andquantitative methods in data analysis in insect ecologyand population dynamics are required. Research empha-sis is on thc biological control of insects and otherartropods that are pests of agriculture in Califomia, insuc areas as host/parasitoid, prey/predator interactions;procurement and colonization of parasitoids and preda-tors; recogtion and selection of biotype of naturalnenems; eoogical and economic evaluation of natural

enemies. Foreign exploration for exotic parasitoids andpredatrs is expected Tea will be an undergraduatecours n bloical control, graduate seminars, andguidance of grauat students.Appcans should send full curriculum vitae, list of

publications and -manuscripts, official transcripts of allcollege-lvl work, the names of three persons as refer-ence, and a statemet of purpose by 15 July 1988, to

D. L. Dahlstn, ChairDivision of Bioloical Control

University of CaforniaBerkeky, CA 94720

The Univenuy ofCa nia is an Equal OprtunitylAlinn Aain Emjpoyer.

GUEST RESEACHER (EPIDEMIOLOGISrORIMMUNOLOGIST/MICROBIOLOGISI). TheNaval Dental Research Institute (NDRI) seeks regular orsenior level apnts with research doctoral degrces (orcompktion ofrequrements) appropriatetothe stdy of(i) dental di epidemiology or treatnnt resourcemanagement, or (ii) the immunology and miucrobiologyof periodontal disase. Rceocation rcimbursement plus

ofS26,350 wiU bc rovided for ten-ures ranging from3 months (senior only) to 1 ycar, withpossible extension. Equal Eplopyment O andnon-US cttszse. Contact: Dr. M. E. Cohcii(i)or Ir. LG. Simonson (ii), NDRI, Building 1-H, NTC, Great

IL 60088.

I230

Position availabk for M.D. OR Ph.D. with at least 3years ofcxperience in molecular and ccllular biology, anda strong mnterest in the study of genes invo ed inproliferation and differentiation of leukemic cells. Musthave expertise in: (i) Flow cytometric analysis, (ii) use ofantisense oligonudeotides, (iii) study of growth factorsand their receptors, (iv) DNA and RNA analysis. Salarycommensurate with qualifications. Please send curricu-lum vitae as wcll as names ofthree references to: Janet D.Rowly, M.D., University of Chicago, 5841 SouthMaryland, Box 420, Chicago, IL 637.

MICROBIAL IRON TRANSPORTPOSTDOCTORAL RESEARCH ASSOCIATEThe Collce1 of Chemistry, University of California at

Berkeky, invites applications for the position ofMicrobi-al Iron Transport Postdoctoral Rescarch Associate. Thisis a postdoctoral research position at 50 to 100% variabletime with an annual salary of $20,000 plus fringebenefits. A Ph.D. in microbiology and/or biochemistry isrequired and specific experience m microbial iron trans-port is desirabk. The research appointment will involveIron transport studies and microbial systems utilizingsiderophore-mediated iron transport. Growth ofscmicroorganisms and their mutants, transport assays andsome coordination chemistry rescarch will be involved.The candidatc will be expected to work independentlywith the research activities and must have the ability tocommunicate both in writing and orally the researchresults. Experience with modem instrumnctation thisfield and thcir supervision is needed.

Candidates should submit curriculum vitae, includinga list of publications, and thrce letters of reference to:Professor Kenneth N. Raymond, College ofChemis-try, Univr~of Califonia at Berkeley, CA 94720.I'he deadlinc for reccipt of applications is open untilposition is filled.

The Univnty of Calfornau is an Equal OpportunitylAffirmatie Action Emplyer.

MICROBIOLOGISI-GENETICIST. The BiologyDepartment, Missouri Southem State College, invitesapplications for a tenure-track position with teachingresponsibilities to include microbiology, medical micro-biology, pathologic microbiology, genctics, general biol-ogy, viroogy, and immunology. Ph.D. preferred with astrng commitment to undaduate teaching and re-search. Cell and mokcular emphasis is desirable. Applica-tion deadline is 15 June 1988.Send a letter of application, curriculum vitae, and three

kttcrs of reference to:Dr. Ray A Malzahn, DcanSchool of Arts and Sciences

Miouri Southr Sta CoilegeJoplin, MO 64801-1595

Misouri Soutbhern State CoUege i an Equal Opp nitylAffirmativAcaion Emplyecr.

Agricultural United StatesS Rsearch Department of

ServIce AgricultureU.S. DEPARTMENT OF AGRICULTURE

AGRICULTURAL RESEARCHSERVICE (ARS)

MOLECULAR BIOLOGYPOSTDOCTORAL RESEARCH ASSOCIATEAppalachian Soil and Water Conscrvation Research

Laboratory, Becdly, Wcst Virginia, ARS, is seeking amolecular biologist to join a group investigating soil-root interactions. Mode system involvcs usc of root-colonizing Pseudomonas strains and forages. Successfulcandidate will be responsible for development of recom-binant DNA molecules, especially dervativeslacZY insert, sutabl for tr eneicallyemicrorganisms in soils. Ph.D. with knowiede in pro-caryotic molecular biology and cxperience in tansposi-tion, plasmid construction, transformation, and cloniis required. Salary is $27,716 (GS-11) or $32,218 (GS-12). New laboratory, well-equipped. For furthe infior-mation, contact: Dr. T. E. Staley at 304-252-6426.For information on application procedures and forms,contct: Alice MacNamara, 301-344-8560 by I Au-gust 1988. Applications in rcsponsc to the adverismentshould be marked 8N021 and must be received by 1September 1988. ARS is an Equal Opptnity Emplyer.Woimen and Minoriies are Encourage toApp4y.

SCIENCE, VOL 240

POSITIONS OPEN POSITIONS OPEN

POSITIONS OPEN

MOLECULAR CELLBIOLOGISI/IMMUNOLOGIST

THE UNIVERSITY OF CHICAGOTHE BEN MAY INSilTUTE AND

THE DEPARTMENT OF PATHOLOGYThe Ben May Institute and the Department of Path6l-

ogy of thc University of Chicago arc seeking applicantsfor at Icast two junior faculty positions. We are commit-ted to developing strong programs in the molecularaspects of the control of cell growth and differentiation.We are seeking outstanding individuals who are usingthe approaches ofmolecular biology or cell physiology toexaminc basic mechanisms of cell signaling events orregulation of gene expression. Existing related researchprograms in the Ben May Institute and the Departmentof Pathology indude molecular and genetic aspects ofreceptor signalling mechanisms involving steroid hor-mone receptors, growth factor receptors, and T lympho-cyte actaivation and regulation. Candidates should havesufficicnt research experience to demonstrate both signif-icant accomplishment and outstanding promise. Letersof application including curriculum vitae, bibliography, abrief statement indicating research interests, and thenames of three references should be sent to: Dr. FrankFitch, Director, Bcn May Institute, The University ofChicago, Box 424, 5841 South Maryland Avenue,Chiago, IL 60637.

MOLECULAR GENETICIST. Children's Hospitalof Western Ontario, Child Health Research Institute. Afiull-time academic appointment, University of WesternOntario, Department of Pediatrics, Division of MedicalGenetics. Requirements: Ph.D. in biological sciences,strong research interest in basic or applied human geneticdiscase. Forward curmculum vitae to: Dr. J. IL Jung,Children's Hospital of Westen Ontario, 800 Com-

iasioners Road East, London, Ontario, N6C 2V5.In accordanwc with Canadian Immjqration requieents,this advertisement is directed to Canadian Ctinem andpenmanent residents ofCanada. This is an Equal Opportuni-ty Etployer. Closing date for applications: 31 August1988.

NEUROIMMUNOLOGY RESEARCH COOR-DINATOR Individual with tcchnical cxpertise issought for the creation and production of monoclonalantibodies towards defined brain molecules and their usefor neuroimmunologic research. Considerablc indepcn-dence and an opportunity for career advancement wil bestrongly encourged and available to the right person.Competitive salaiy and xcellent benefits. Pkase contact:Dr. Howard Filht, Box 1070, Ihe Mount Sinai SchoolofMoedicie, Fisberg Resarch Center forN urobiolo-gy and Department of Geriatrics, One Gustave L LevyPlace, New Yorlk, NY 10029-6574. Teephone: 212-241-7557. An Equal Oppotunity Emplyer.

OPHTHALMOLOGIST to head Section of Molec-ular Biology and Genetic Eye Discase in the DepartnentOf Ophthalmology and Visual Science, Yale niversity

School of Medicmc. Training and record in clinical andmokcular genetics. Will bc expected to direct teachingand research programs in section. Send curriculum vitaeand bibliography to: Chairman, Search Committee,Dqmaement of Ophthalmokgy and Visual Scicnce,

Un ty Sool of Meci, P.O. Box 3333,Newv Haven, CT 06510. Affiative ActionEqual Op-porunity Employer.

27 MAY 1988

Commonwealth of AustraliaBureau of Mineral Resources,Geology and GeophysicsSENIOR RESEARCH

SCIENTIST ORPRINCIPAL RESEARCH

SCIENTIST ORSENIOR PRINCIPAL

RES;EARCH SCIENTISTThe Bureau of Mineral Resources, Geology and Geophysics (BMR),

Canberra, invites applications from suitably qualified women and men for thefollowing position for a Research Scientist in the field of Regolith Development.

Canberra, the Nation's Capital, is an easy two hour drive to thesnowfields in the South or the coastal fringe to the East. Sydney is three and ahalf hours drive to the North-East. Comprehensive sporting and recreationalfacilifties are available, and it has excellent public and private schools and tertiaryinstitutions.

The Division of Petrology and Geochemistry is responsible for a newprogram designed to understand the distribution and the origin of the AustralianRegolith through a co-ordinated approach comprising geomorphology,geochemistry, remote sensing, geophysics etc. The objective of this program isto determine the nature, composition and evolution of the regolith, andunderlying or contained resources including mineral deposits and groundwater.DuOs:

The successful applicant will lead a small team to develop this programand will have a geological background and special interest or expertise inprocesses involved in regolith development. Specialist knowledge of oneor more of the following areas: geomorphology, sedimentology, remotesensing or low-temperature geochemistry would be an advantage.

QkaHficalons:Qualified for admission to a degree of Doctor of Philosophy or equivalentqualification, and appropriate research experience. PhD or equivalent ingeology, with extensive postgraduate experience, demonstratedresearch ability and a strong publication record.The level of appointment will be determined by the successful applicant's

qualifications and experience and will be in one of the following categories:Senior Research Scientist $A36,734-$A42,174Principal Research Scientist $A43,741-$A49,569Senior Principal Research Scientist $A52,183-$A57,276Conditions of service in the Australian Public Service include four weeks

recreation leave per year plus bonus, cumulative sick leave, long service leave,comprehensive superannuation scheme and costs of relocation to Canberra.

To be eli9ible for permanent appointment to the Australian PublicService, an applicant must hold Australian Citizenship. However, a successfulapplicant accepted for immigration, and intending to apply for AustralianCitizenship, may be appointed to the Service on probation. Such an appointmentwould be confirmed when citizenship is granted. Fixed term temporaryemployment of up to five years may be negotiated for a successful applicant whois not eligible for permanent appointment to the Service.

Applications together with full personal and professional details and thenamres of at least three referees should be sent to: The Secretary, Department ofPnmary Industries and Energy, PO Box 858, CANBERRA, ACT 2601,AUSTRALIA. Ref: NPPG.

ATTENTION: Recruitment Officer.Applications close: June 30,1988.

NEUROVIROLOGY POSITION at thepostdoctoral fellow or research associate level isnow available at Memorial Slan-Kettering Can-cer Center. NIH-funded studics dcal with theviral pathogenesis of HIV infection of the ner-vous system and the AIDS Dementia Compkx.The position requires a background in pathogc-netic or molecular virology or cell biology. Salary

is commnsurat with previous traning and

experience. Please forward curriculum vitae and

three references to: Richard W. Price, MD.,Department of Ncurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue,New York, NY 10021.

II

0 mimi

SCIENTISTSGenencor, Inc. is a dynamic and growing biotechnology companylocated in South San Francisco, Califomia. We specialize in theresearch and development of enzymes and enzyme processesas well as the production of industrial enzymes. We are activelyrecruiting for two positions in our Development Department:

BACTERIAL PHYSIOLOGIST. Develop and evaluate micro-bial hosts for the large scale production of useful proteins. Con-duct and optimize fermentations on both the laboratory and pilotplant scales. Requires Ph.D. or equivalent in microbiology orrelated field. Knowledge of genetics and genetic techniques isessential. Some knowledge of engineering principles is useful.Refer to Dept. MA.

PROCESS BIOCHEMIST/PROTEIN CHEMIST: Extract,purify and characterize enzymes from both bacterial and fungalbroths. Working as part of a project team, this individual willdevelop and implement purification schemes for large scalerecovery operations. Some travel is required. Requires Ph.D. inbiochemistry or a related field and two years post-doctoral experi-ence. Some pilot plant or production experience in industry ispreferred. Strong interpersonal and communications skills areessential. Proven project management and supervisory skills aredesirable. Refer to Dept. HMD.

We offer an outstanding compensation and benefits packagecombined with the opportunity to make a significant contributionto our dynamic organization. To apply, please send your resumeto GENENCOR, Inc., 180 Kimball Way, South San Francisco, CA94080. Attn: Human Resources. Please note appropriate Dept.Genecor is an equal opportunity employer.

GENENORn

orateTechnologyWe're looking for a leader

U.g... to step in and take charge.a _W

Fortune 100 Combustion Engineering, a diversified$3 billion company needs a seasoned pro to head up anddevelop major technology programs. Someone with excellentcommunication and interpersonal skills who can represent usin the professional community, and help strengthen our imageas a leader in technology.

As Director, you will be expected to provide leadershipin, and identify, technology opportunities for us. Additionalresponsibilities will be to review and monitor major researchand development programs.

This leadership role requires a PhD in Engineering,Physical Sciences or applied mathematics. The ideal candidatewill have more tn one of these disciplines in their background.However, if you have 5 to 10 years in advanced technologyprogranr management, your experience is worth as much asan advanced degree. We will also consider tenured facultywho may be seeking 2-3 years industrial experience while onuniversity leave.

We offer competitive salaries, a complete benefitspackage and excellent prospects for professional developmentand growth. For prompt, confidential consideration, please sendresume with salary history/requirements, to: Director of Staffing,Combustion Engineering, 900 Long Ridge Road, PO. Box 9308,Stamford, CT 06904. An equal opportunity employer M/FN/H.

cOMIBUSIIONEN6EUEERING

CONSERVATION

Our client, a N.Y. based inter-national conservation organi-zation, seeks a new Directorand Chief Spokesperson pos-sessing significant experiencein conservation or internation-al development. The success-ful candidate will have abilitiesin management, fund raising,long range planning and gov-emment and public relations.Please forward resume withsalary history to:

MONACO & ASSOCIATES3761 Indian Hill RoadShrub Oak, NY 10588

Equal Opportunity Employer M/F/HN

U.~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

NATIONAL INSTITUTESOF HEALTH

PUBLIC HEALTH SERVICEStaff Fellowship in CellBiology-Experimental

MorphologyThe Laboratory of Neurosciences, NationalInstitute on Aging, National Institutes ofHealth (NIH), invites application for a Staff orSenior Staff Fellowship position to study thestructure of peripheral nerve and brain, withparticular reference to the blood-nerve andblood-brain barriers; as well as cell surfaceproperties determining morphogenesis in thenervous system. The successful candidateshould be competent in light microscopy andelectron microscopy, with demonstrated ex-perience in freeze-fracturing, rapid freezingand scanning techniques, as well as tech-niques of tritiated autoradiography, enzymehistochemistry, immunocytohistochemistryand possibly in situ hybridization.Applications are invited from qualified in-dividuals having a Ph.D., M.D., or both, withexperience in cell biology and morphology ofthe nervous system. Salary range is $20,000to $43,452 commensurate with qualifica-tions. Interested candidates should submit aCurriculum Vitae and a statement of re-search interests, as well as three letters ofrecommendation, to Stanley I. Rapoport,M.D., Chief, Laboratory of Neurosciences,National Institute on Aging, NIH, Bldg. 10, Rm.6C-1 03, 9000 Rockville Pike, Bethesda,Maryland 20892.

NIH IS AN EOUAL OPPORTUNITY EMPLOYER

w

.d

PuttingTechnology NATIONAL UNIVERSITY OF SINGATo Work INSTITUTE OF MOLECULAR & CELL Bl

Battelle, Pacific NorthwestLaboratories performs research POSTDOC ORAL FELLOWon energy technology develop- Applications are invited for appointment as Postdoctoral Fellowsment waste management Molecariand Ce Biology.

technology along with the en- Molecular and Cell Biology.vironmental biomedical im- The Institute was recently established to undertake basic

pamtiofdthesetechnologies.Join cal research. It will also provide training at pre- and post-doctoralamultioiciplinaryteamofsinter- has three principal research areas related to Cell Regulation, Infeand engineers providing Diseases and Molecular and Cell Biology of Plants.aginative and practical solutions The Institute, which is adjacent to the University's biomedical complto complex technical challenges. University Hospital, has 19 laboratory modules of 1,0OO square fei

Manager Chemical Successful candidates will be pursuing research in one of the folloPapilloma Virus, Molecular Immunology, Molecular Biology olNeurobiology (eg. Gene expression in brain), Protein Engineerin

Our Materials and Chemical Biology as well as Biochemical and Cellular Basis of Cell Regulati4Applications Department has anoppencationg thepManager os a Salary will be commensurate with experience; leave, medical and oChenical process Devlopment provided. Applicants should send their curriculum vitae and namesSection. The section conductschallenging research for the DirectorDepartment of Energy, other P Departmentgovemment agencies, and in- National University of Singaporedustrial clients in areas such as 10 Kent Ridge Crescent

remediation treatment for hazar- Singpore 0511,dous wastes and innovative

singaporethermochemical and catalytictechnology. Psition requiremerts PERSDEPT@ NUSVM

include:

Advanced degree in ChemicalEngineering or Chemistry andproven management anddevelopment of R&D 1 (JLECULA B14DLMinimum of ten years' exper- HYPE'R CHOLESTEROLEience in research or industrial ER CHOL ERL EJ

chemical engineering, including The Squibb Institute for Medical Research recognizedseparations and recovery pro- a leader in the research and development of novel theralcesses, thermochemical con- the of cardiovascular has

version proceses, biochemical opportunity available for an experienced research assoprocesses, andprocessmode Cellular Biology Department.

ing.

*Technical leadership, planning, You will be responsible for conducting experimentand research project develo cholesterol biosynthesis and transport with particular erment in new research areas regulatiorn. Qualified candidates must have a B.S. (Mdealing with broad aspects Molecular Biology or Biochemistry and a minimum cof physical and inorganic research experience. A working knowledge of protechemistry. biochemistry,molecular biology mammalian

You will join a group of highly talented scientists enga

In addition to our unique research disciplinary approach to the study of hypercholesterolerenvironment and the innovative We offer excellent salary ben

scope of our projects, Battelle of-well as the opportunity to pursue a stimulating and rewa

fersacomprehensivecompensa- confidential consideration please submit your resume tohighly stituteforMedicalRsearch HumanResocesDepar

desirablebcation for recreational Box 4000 Princeton New Jersey 08540.pursuits. Send resume, salaryhistory, current salary re-quirements and references to:LorenP. Henderon,B1t1l1e, JJJ

paNdf atis omtxes,~P.O. Box 999, Dept. 038, -Richland, WA 99352.

U.S. citizenship required. We are an

equal opportunity employer M/F

Where science comes tolife.

r

LPOREIOLOGYJSs in the Institute of

I and biotechnologi-levels. The Instituteectious and Genetic

olex and the Nationalet each.

wing areas: Human)f Stress, Molecularng, Plant Molecularon.

ther benefits will beand addresses of 3

)GISTMIAinternationally asipeutic agents forve an exceptional)ciate to join our

:sin the area ofmphasis on geneL.S. preferred) inDf 1 year relatedein and enzymeiture is desirable.aged in an inter-rnia.

nefits package asirding career. Forx The Squibb In-rtment 800,PO.

D isaneniewS nfc Nor%- UbworLoesI

0

POSITIONS OPENPOSITIONS OPEN

PHARMACOLOGIST to serve as Chief of theBiochemical Pharmacology Branch, Pharmacology Divi-sion, US Army Medical Research Institute of ChemicalDefense, Aberdeen Proving Ground, Marvland. Respon-sible for supervising and managing fundamental researchon mechanism of action of toxic agents and the develop-ment of concepts of prophylaxis and therapy. Qualifiedapplicants must have established expertise in biochemicalpharmacology as indicated through peer reviewed publi-cations. Demonstrated ability to efficiently and effectivelymanage and supervise research teams is highly desirable.

Salary range $46,000 to $60,000 per annum. Thesuccessful candidate will likely have a Ph.D. degree inpharmacology or related field. This position is in the civilservice job category pharmacolop/chemist GM-405-14/GM-1320-14. U.S. Citizenshi s required and the appli-cant must be abk to obtain a security clearance.Send r6sumes by 1 July 1988 to: Commander, US

Army Aberdeen Proving Ground, Attention:STEAP-PA-CR-D (Ms. Bynum), Aberdeen ProvingGround, MD 21005. Equal Opportunity Employer.

PHYSIOLOGYFull-time, TENURE-TRACK POSMIION avail-

ablc. Rank commensurate with experience. Responsibil-ities include restructuring and implementing the basicphysiology course for dental students and developing astrong research program. Current research interestsshould include basic/applied physiology. Applicant mustbe willing to interact with other basic/clinical scientists atthe School of Dental Medicine. An Equal OpportunitylAffirmative Action Employer.

Send curriculum vitae and references to: Dr. B. F.Hammond, Associatc Dean ofAcademic Affairs, Uni-versity of Pennsylvania School of Dcntal Mcdicine.4001 Sprucc Street, Philadelphia, PA 19104.

PLANT MOLECULARBIOLOGIST/BIOCHEMIST

The United States Department of Agriculture, Agri-cultural Research Service, Cereal Crops Research inMadison, Wisconsin is seeking a plant molecular biolo-gist/biochemist to do research on gene expression andenzyme regulation in barley and oats as it relates tomalting and nutritional qualitv. Candidates should haveknowledge and experience in recombinant DNA proce-dures and plant biochemistry. Postdoctoral experience isdesired. Must be U.S. citizen. Salary is commensuratewith experience ($27,716 to $51,354). For informationon research program or position contact: Dr. David M.Peterson on 608-262-4482. For information on appli-cation procedures and forms contact: Janie Carr on301-3444569. Applications in response to this adver-tisement should be marked 8N024, and sent to: U.S.Department of Agriculture, Agricultural ResearchService, Personnel Operations Branch, Northern Sec-tion, MWA, Building 419, BARC-East, Beltsile,MD 20705. Applications must be received by 28 June1988. An Equal Opportunity Employer.

POSTDOCTORAL FELLOWSHIP: Available thisyear to study erythropoietin receptor and mechanism ofaction of erythropoietin and Friend virus on erythroiddifferentiation. Research will involve cell isolation, pro-tein purification, and molecular biology of initiation ofgene transcription. This position offers a good chance tocombine molecular biology with cell biology in the studvof terminal differentiation. Send curriculum vitae andnames of three references to: Dr. Sanford B. Krantz,Vanderbilt University, Medical Center North, RoomC-3101, Nashville, TN 37232. An Equal OpportunitylAffirmative Action Employer.

POSTDOCTORAL FELLOWSHIP/RESEARCHASSOCIATE position available 1 July 1988 in NIH-funded basal ganglia neuropharmacology project whichwill examine interactions among dopamine receptors andGABA/substance P metabolism. The successful applicantwith M.D. and/or Ph.D. degree(s) will utilize techniquesof regional brain drug injection and microdialysis, quan-titative autoradiography, radioimmunoassay and HPLC.Clinically qualified M.D.'s may also participate in theMovement Disorders Program, if desired. Send curricu-lum vitae and three letters of reference to: James P.Bennett, Jr., De atment of NeurologW, Box 394University of Virginia School of Medicine, Char-lottesville, VA 22908.

POSTDOCTORAL ASSOCIATETwo postdoctoral positions are available beginning 1

July 198 for research involving mechanistic studies ofbiological thiol/disulfide exchange processes. Areas ofresearch interest include the mechanisms of disulfidebond formation during protein folding, catalysis of thiol/disulfide exchange, and regulation of enzyme activity bythiol/disulfide exchange. Experience in enzymology, pep-tidc chemistry, protein purification, or metabolic controlis required. Salary: $18,000 to $21,000 per vear (plusfringe benefits) depending on qualifications. Send curric-ulum vitae and three letters ofrecommendation to: Dr.H. F. Gilbert, Department of Biochemistry, BaylorColiege of Medicne, Houston, TX 77030. BaylorCollege ofMedidnc is anAffirmativeActionlEqual Opportu-nity Employer.

POSTDOCTORAL FELLOW. Position available inthe Department ofTherapeutic Radiology, Yale Univer-sity School of Medicine. Position available as early as 1June 1988 for a postdoctoral fellow interested in pursu-ing questions relevant to the autocrine and paracrinecontrol of growth proliferation and stromal invasion inovarian, endometrial and other adenocarcinomas, as wellas the cffects these growth factors exert on tumor cellresponse to DNA-damaging agents, such as x-rays anddrugs used in cancer chemotherapy. Preference will begiven to applicants with experience in protein chemistry,molecular biological techniques and mammalian cellculture. Applicants should submit a letter describingtheir researcintere, along with a complete curriculumvitae and letters of reference to: Barry M. Kacinski,M.D., Ph.D., Department ofTherapeutic Radiology,Yale University School of Medicine, 333 CedarStreet, New Haven, CT 06510.

POSTDOCTORAL POSMIION. Available Septem-ber 1988, for collaborative studies of growth factorsynthesis and function in hormone responsive and unre-sponsive prostate cancer cells. Molecular studies of hor-mone regulated growth factor gene expression and bio-chemical studies of growth factor function will be Dur-sued with Dr. Sydney A. Shain. Candidates must havestrong background and laboratorv experience in celibiology and/or molecular biology. Send curriculum vitaeand the names and telephone numbers ofthree referencesby 31 July 1988, to: Personnel Director (847), South-west Foundation for Biomedical Research, P.O. Box28147, San Antonio, TX 78284. Equal OpportunityEmployer MIF.

Massachusetts Institute of Technology/Department ofBiology POSTDOCTORAL POSIT ON available im-mediately to investigate the molecular events responsiblefor microbial genetic recombination and mismatch re-pair. Send curriculum vitae and names of three refereesto: Dr. Maurice Fox, Department of Biology, Massa-chusetts Institute of Technology, Cambridge, MA02139.

POSTDOCTORAL POSITION available for studyof the anatomy and physiology of cerebellar circuitsinvolved in limb movement. Main emphasis ofresearch ison single unit recording (recording) during movementand on WGA-HRP neural tracing. Researcher will col-laborate with Pcter van Kan and Alan R. Gibson. Sendresume and description of research interests and skills to:Alan R. Gibson, Barrow Ncurological Institute, 350West lhomas Road, Phoenix, AZ 85013. Telephone:602-285-3732.

For the biologically inclined: POSTDOCTORALPOSMIION available. This is a once-in-a-lifetime op-portunity to explore the development of the vascularsystem from its very beginning. Only enthusiastic, highlyqualified, industrious individuals truly curious about thebiology of development need apply. The position isavailable immediately. The Wistar Institute is a non-profit research institute located on the University ofPennsylvania campus. It provides an excellent researchenvirornent with ample opportunity to interact withindividuals at the institute as well as at the universitv.Interested indivduals should send resume and threeletters of recommendation to: Clayton Buck, Directorof Scientific Development, The Wistar Institute,3601 Spruce Street, Philadelphia, PA 19104. EqualOpportunity Employer, MIF.

POSTDOCTORAL POSITION available 1 July1988 to study transferrin receptors in African trypano-somes. An interest in receptor mediated processes and abackground in protein purification or recombinant DNAtechniques is desirable. Send curriculum vitae to: Dr.Larry Ruben, Department of Biology, SouthernMethlodist University, Dallas, TX 75275. Equal Oppor-tunitylAffirmatveActum Employer.

POSTDOCTORAL POSMIION available immedi-ately to study synaptic plasticity or synapse elimination atthe neuromuscular junction. Teehniques include repeat-ed in vivo observation with video microscopy, imageprocessing, electrophysiology, histology, and histochem-stry. Send curriculum vitae and names of three refer-ences to: Dr. Albert Herrera, Neurobiology Section,Biological Sciences, University of Southern Califor-nia, Los Aneles, CA 90089-0371. Equal Opportunity!Affirmativc Action Employer.

POSTDOCTORAL POSMIION available immedi-ately for structure/function studies of nuclear proteins inskeletal and cardiac myogenesis. A stron background incell and molecular biology is required. This position ispart of an NSF Center o Excellence in Cell and Molecu-lar Biology Program developing at Meharrv MedicalCollege. Minority candidates are encouraged to apply. Sala-ry commensurate with experience. Submit curriculumvitae and two references to: Dr. Jaswant S. Bhorjee,Division of Biomedical Sciences, Meharry MedicalCollege, 1005 D.B. Todd Boulevard, Nashville, TN37208. Equal Opportunity Employer.

POSTDOCTORAL POSITION available immedi-ately for research in (i) purification and characterizationof components of the hemidesmosome, a kev cell-matrixcontact in normal and wound-healing epidermis and (ii)control of expression of the differentiation marker, kera-tinocyte transglutaminase. Salarv $18,000 to $22,000.Contact: Scott M. Thacher, Department of MedicalBiochemistry and Genetics, Texas A&M University,College Station, TX 77843. Telephone: 409-845-0828. An Equal Opportunity Employer.

POSTDOCTORAL POSITION available for stud-ies on the neural control of blood flow in the choroid ofthe eve. These studies will involve a combination ofanatomical (immunohistochemistrv, pathway tracing,LM, EM) and phvsiological techniques (laser-Doppler,neurophysiology) to identify the circuitrv and transmit-ters involved in control of choroidal blood flow, deter-mine their precise role and clarify their importance forouter retinal health. An interest in vision or previousexperience with neuroanatomical or immunohis-tochemical techniques desirable. Salarv based on experi-ence. Contact: A. Reiner, Departnent of Anatomyand Neurobiology, Univcrsity of Tennessee, Mem-phis, TN 38163.

POSTDOCTORAL POSITION available to studycellular events underlying the development of neuronalpolarity. Research concerns the determination of theaxon and dendritic growth and branching by hippocam-pal neurons in culture, using time-lapse and computer-enhanced video microscopy, immunocytochemistry andelectron microscopy, microsurgery and microinjection.Send curriculum vitae, description of research back-ground and interests, and names of three references to:

Banker, Department of Anatomy, AlbanyMedical College, Albany, NY 12208.

A POSTDOCTORAL POSITION for challengingresearch in computer modeling of macromolecular struc-tures will be available 1 July 1988 at the University ofKansas. Ph.D. in chemistry or closely related field isrequired. Strong background in structural bioorganicchemistry or protein crystallography as well as program-ning experience in a VAX/VMS environment required.Familiarity with computer graphics and molecular me-chanics/dynamics software desired.

Salary will range from $20,000 to $24,000, dependingon qualifications and experience. Interested candidatesshould send their curricuum vitae and two letters ofreference by 15 June 1988 to: Dr. A. Vedani, Depart-ment of Chemistry, University of Kansas, Lawrence,KS 66045. An Equal OpportunitylAffimative ActionEmployer.

SCIENCE, VOL. 240I234-

POSITIONS OPEN POSITIONS OPEN

Atherosclerosis-Vascular Biology Research

The Upjohn Company, a leader in pharmaceuticalresearch, is expanding its Atherosclerosis Research pro-gram and is seeking a scientist to initiate and carry outoriginal research directed toward understanding themechanisms of atherosclerosis. The successful candidatewill join our Metabolic Diseases Research Unit and willinterface with both physiologically and chemicallyoriented laboratories to investigate how specific chemicalmodulators of cell functions can be used to both elucidatethe mechanism involved in the development ofatherosclerosis and to treat the disease- The successful can-didate will collaborate with our scientists working on theintegration of the phenomena of vascular cell injury, cellproliferation and infiltration, lipoprotein metabolism, andlipid accumulation. Effective communication of results,both orally and in writing, is expected as well as publica-tion of research data.Candidates should have a Ph.D. degree in a medicalscience, preferably pharmacology, with a minimum of 2years of relevant postdoctoral experience. Expertise in

both biochemical and physiological approaches to study-ing blood vessel disease is required; expertise in studyingcells in culture as well as lipid metabolism is desirable.Ability to extend in vitro findings to intact tissues or toin vivo models is also desirable.Upjohn is located in Kalamazoo, in southwestem Michigan,midway between Chicago and Detroit, and offers variedcultural events, cosmopolitan shopping and entertainment,lakes and woodlands minutes away, abundant year-roundsports and recreation. Upjohn offers a stimulating researchenvironment, excellent salary, comprehensive benefits andcareer potential. For prompt, confidential consideration,please send your CV/resume, list of publications and namesand addresses of references, to M. William Rex, CorporateEmployment, The Upjohn Company, Kalamazoo, MI 49001.Please refer to advertisement number 22904-HA in yourcorrespondence. We are an Equal Opportunity EmployerM/F.

Our Commitment to ScientificExcellence Continues ...

JIUAs UGLAXO INSTiTUTE FOR IOLECULARnOLOGY SiL

The Geneva biotechnology research unit of a large UK pharmaceutical group has a vacancy in thedepartment of Molecular Biology for a specialist in

animal-cell expressionto investigate gene regulation in animal cells.

The Glaxo Institute for Molecular Biology provides a molecular basis for the discovery of effective newmedicines. Projects include viral therapeutics, inflammatory diseases, and regulation of cell prolifera-tion and differentiation.Situated in the attractive city of Geneva, the Institute has a staff of over one hundred, grouped in smallteams of specialists from several domains of modern biology. We are part of the Glaxo Group - one ofthe largest pharmaceutical companies in the world - which has an outstanding reputation for the qualityof its research and products. The Institute offers an excellent salary and benefits package, as well as aninteractive research environment.The ideal candidate will have several years postdoctoral research experience and a proven track recordin the field of animal cell expression. Experience with viral systems - retroviral in particular - would bean advantage.If you are interested in this position, please send your curriculum vitae with a list of publications and thenames of three references to: Rita Gloor, Personnel Manager, GLAXO IMB SA, 46, route des Acacias,1211 Geneva 24, Switzerland.

I , Memorial Sloan-Ketering_ "^ Cancer Center

IMMUNOLOGY PROGRAM

r.WIJ.

The Immunology Program at the Memorial Sloan-KetterngCancer Center is seeking applications from immunologists forseveral tenure-track faculty positions. The potential candidateshould be using modern genetic, biochemical and molecularbiological techniques to study problems in the areas of cellsurface antigens and receptors on lymphocytes. The specificrank of appointment will be commensurate with the candidate'sexperience and achievements. This is an expanding programconsisting of 16 faculty members with diverse interests in theareas of immunogenetics, cellular immunology and tumorimmunology, who are committed to basic research and thetraining of graduate and postdoctoral students. Excellent startup funds and space available.Please submit your curriculum vitae, a brid sbtement ofpresent and future research goals and the names of threereferences to:

Dr. Osias StutmanChairman, Immunology Program

Sloan-Kettering Institute1275 York Avenue

New York, New York 10021SKI is committed to equal opportunity through affirmative action and,therefore, members of minority groups are encouraged to apply.

Staff ResearcherSyntex, an international leader in the pharmaceuticaland health care industry, has an immediate openingfor a Staff Researcher in our Institute of Pharmaceu-tical Sciences.You will work independently, designing and executingexperiments to develop and characterize liposomes foruse as potential drug delivery systems. Other duties in-clude supporting activities related to drug solubilization,formulation and bioavailability utilizing liposomes andassisting basic research related to liposome-cellinteractions.To qualify, you must have a PhD in Biochemistry, Phar-maceutics, Pharmacology or Chemistry and up to sixyears' experience with liposome technology. Workingknowledge of electron microscopy, particle sizing, con-tact angle measurements, fluorescence spectroscopyand chromatography is also required.

Syntex offers a competitive com-= pensation and relocation package

in campus-like surroundings. Forimmediate consideration, pleasesend your resume to: Syntex,Professional Staffing, Dept.KH/SR, 3401 Hillview Ave., PaloAlto, CA 94304. An equal oppor-tunity employer.

The University of British Columbia

HEAD, DEPARTMENT OFPLANT SCIENCEVancouver, B.C.

Applications and nominations are invited for the position of Head of the Departmentof Plant Science.The Department is a unit within the Faculty of Agricultural Sciences. It has acomplement of full-time faculty, 18 part-time lecturers and adjunct professors, and12 full-time stat. Undergraduate students number 80-100 and there are 45 graduatestudents enrolled in Masters and Ph.D. programs.The Department ofers undergraduate programs leading to the B.Cc.(Agr.) and tothe B.L.A. (Landscape Architecture). Research and graduate programs are wellestablished in several fields; agronomy, biotechnology, crop physiology, entomolo-gy, genetics, horticulture, plant pathology, range ecology, and weed science.The Head will be expected to provide academic and administrative leadership for thefull range of programs in the Department; to foster a stimulating and congenialacademic environment; and to maintain elWective working relationships with otheracademic units and with related research and professional groups.The appointment as Head will be for a five-year term which may be renewed. Theacademic appointment is expected to be at the rank of Professor and is subject tofinal budgetary approval. Salary negotiable, depending on qualifications. Thesuccessful candidate will have a strong research program, a commitment toexcellnce in teaching and will have demonstrated evidence of leadership andadministrative ability.Applications must indude a curriculum vitae and the names of at least threereferences.Coresponidnce shuld be mont by Au t 31, 1988 to:

Dr. J.F. Richards, Dean,Faculty of Agricultural ScIenc

Room 248, 2357 MaIn MalVancouvr, B.C. V6T 2A2

The University of British Columbia oters equal opportunity for employment toqualified male and female candidates. In accordance with Canadian Immigrationrequirements priority will be given to Canadian citizens and permanent residents ofCanada.

The Faculty of Medicine, University ofGeneva, has an opening for a

FULL PROFESSORin its Department of Biochemistry.This is a full time post. It involves the di-rection of a research programme at theinternational level in some aspect of ac-ademic or clinical biochemistry; 35hours per year of lectures and seminars(in French); responsibility for 40 hoursof practical classes; supervision of Di-ploma and Doctoral students.Qualification required: PhD. or M.D.Starting date: 1 October 1988, or

by arrangementApplications should be sent before 25/7to the Secretariat de la Faculte de Me-decine, Centre Medical Universitaire,1 rue Michel-Servet, 1211 Geneve 4,Switzerland, from whom further particu-lars of the post can be obtained.

REQUEST FOR PREPROPOSALSSUPPLEMENT TO THE UNITED STATESARMY MEDICAL RESEARCH AND

DEVELOPMENT COMMANDBROAD AGENCY ANNOUNCEMENT

The U.S. Army has a special interest in preproposals for medical researchdirected toward defining the pathogenesis of and medical treatment forinjuries sustained by exposure to VESICATING chemical warfare agents.Specific areas of interest include the following:

PATHOPHYSIOLOGY AND PHARMACOLOGY FORMEDICAL COUNTERMEASURES STRATEGIES

- General organ systems - Route of entry and biodisposition of toxicagents as related to systemic toxicity.- Skin effects - Toxicity, pathogenesis, and mechanisms of action;identification of the etiology of blister formation and protracted healing.- Etiology, pathogenesis and mechanisms by which sulfur mustardinitiates leukopenia and granulocyte depletion.- Identification and validation of in vivo or in vitro systems to mold theactions of vesicant agents and pharmacological countermeasures.- Respiratory effects - Pathophysiology, pathogenesis and sequelae oflesions, mechanisms of action and suitable pharmacological interven-tion.- Ophthalmic effects - Toxicity, pathogenesis and mechanisms of pho-tophobia and ocular damage.- Pharmacokinetics, metabolism and pharmacodynamics of both expo-sure to vesicants and of candidate prophylactic and therapeutic com-pounds, alone and combined.

DRUG ASSESSMENT- Development of models and criteria for the (pre-IND/NDA) identifica-tion and evaluation of antivesicant compounds which are effective assystemic pretreatment or treatment drugs (both self-aid and medicalcare).- Development of models and criteria for the identification and evaluationof topical barriers which are safe and effecfive in the prevention ofvesicant injury to skin.

MEDICAL MANAGEMENT- Development of effective diagnostic and prognostic procedures ormeasures for field use to assess the extent of patient injury to includerational criteria for triage.- Development of cumulative and acute dosimetry technology for assess-ment of body burden.- Identification and development of clinical medical procedures whichdecrease the burden of patient care and achieve more rapid healing.- Definition and resolution of clinical critical care issues such astreatment regimens, relief of pain and itching, wound care and respira-tory support.

Threat agents of interest include sulfur mustard, lewisite, and phosgeneoxime (Note that nitrogen mustard is not considered a military threat).The goal of this research for the U.S. Army Medical Chemical DefenseProgram is to identify promising self aid, medical countermeasures andprocedures which preserve the capabilities of the armed forces of theUnited States. The United States Army Medical Research and Develop-ment Command supports extramural research by competitive award ofcontracts. Those interested in competing for research funding under thissupplement can obtain a brochore on the application process by writingto the following address:

CommanderUnited States Army Medical Research

and Development CommandATrN: SGRD-ACO (BAA)Fort DetrickFrederick, Maryland 21702-5012

This supplement implies no commitment on the part of USAMRDC tosupport in whole or in part any proposal submitted in response to thecontents herein.

!i

GIBCO/BRL .A Leader in BiotechnologyApplications to Research andIndustry- currently is seekingcandidates for openings inthese areas:.

Molecular BiologyBiochemistryEnzymology

DNA DiagnosticsAs a division of Life Technologies, Inc., GIBCOand BRL are recognized as leading brands inthe field of cell and molecular biology researchproducts... and our success in the marketplacehas resulted in a number of new professionalpositions.They include:Group Leader/instructors forWorkshops, Seminars andTraining Programs* Ph.D. in Molecular Biology; excellent

written, verbal and communications skills

Scientists/Senior Scientists* Ph.D. in Biochemistry/Molecular Biology/Molecular Virology and 2-4 years post-doctoral training with enzyme systemexperience

* Ph.D. in Microbial Genetics or Physiologyand 4 years post-graduate experience

* Ph.D. in Molecular Biology and 2-3 yearsexperience in diagnostic productdevelopment

* Ph.D. with 2 years post-doctoral experiencein molecular biology and immunochemistry

Biochemists/Lab Technicians* B.S. or B.S. in Biochemistry, Biology,Chemistry or the Health Sciences; M.S. insome positions helpful and some experiencein molecular biology.Will carry out development work, planningand experiments in laboratories to supportpresent and new products.

Please send resume or C.V. to:Richard L. Hotaling, Jr., Personnel ManagerDept. BiGIBCO/BRL, Life Technologies, Inc.8717 Grovemont Circle, Gaithersburg, MD 20877(A suburb of Washington, I).C.)

An equal opportunity employer, M/F/V/H

TA

aI yUBHL pNEW InR

I

POSITIONS OPEN

POSTDOCTORAL POSIIION available immedi-ately for NIH funded studies of helminth parasite anti-gens in human filariasis. Work involves antigen analysisand assay development/evaluation. Successful candidatewill have recent Ph.D./M.D. with strong biochemical/immunochemical background. Experience in parasitolo-gy and hybridoma methodology preferred but not essen-tial. Please send curriculum vitae and three references to:Gary J. Weil, M.D., Jewish Hospital at WashingtonUniversity Medical Center, 216 South Kingshigh-way, St. Louis, MO 63110.

THE CENTER FOR BLOOD RESEARCHHARVARD MEDICAL SCHOOL

HEMATOLOGY-BIOCHEMISTRY RESEARCH

POSTDOCTORAL POSMON available to studyintracellular proteolysis in erythropoietic cells of P-thal-assemic individuals. Candidate must have recent M.D. orPh.D. Diligence and honesty essential, experience inprotein biochemistry preferred, independence and cre-ativity encouraged. Send curriculum vitae, statement ofbackground and goals, and names of three references to:Dr. Joseph R. Shaeffer, The Ccnter for Blood Rc-search, 800 Huntington Avenue, Boston,MA 02115.Equal Opportunity Employer.

POSTDOCTORAL POSMON-FISH PHYSI-OLOGY. Two-year postdoctoral/research associate posi-tion available fall 1988 to participate in study of basis forthe rarity of herbivorous fishes in cold temperaturewaters (M. H. Horn, principal investigator). Researchwill involve experiments on metabolism of seaweed-eating fishes. Background in respirometry required; indata acquisition systems highly desirable; in basic fishand seaweed biology desirable. Salary: $20,000 to$22,000 per year. Send letter ofinterest, curriculum vitaeand two letters of recommendation by 15 July 1988 to:California State University Fullerton Foundation,Mahr House, 800 North State Collegc Boulevard,Fullerton, CA 92634.An Equal OpportunitlAffinmatipeAction Employer.

POSTDOCTORAL POSITION IN MEM-BRANE BIOPHYSICS at Harvard Medical School.Several positions are available immediately to studymolecular mechanisms involved in blood cell-endotheialcell, blood cell-parasite, and lymphocyte-target cell in-teractions. Will apply novel biophysical and biochemicaltechniques to studies of dynamic phenomena mediatingmembrane-membrane interactions, including lateral mo-bility, rotational mobility, and distribution of proteinsandlipids on the surfaces of individual cells [see J. CeUBiol. 103, 819 (1986); J. Cell Biol. 105, 1147 (1987);PNAS 85, 1844 (1988); Biochemistry 27, 2661, (1988)].Experience in protein chemistry, fluorescence tech-niques, or instrumentation preferred. Send curriculumvitae, statement of research interests, and names of threereferences to: Dr. David E. Golan, Departmcnt ofBiological Chemistry and Molecular Pharmacology,Harvard Mcdical School, 250 Longwood Avenue,Boston, MA 02115.

POSTDOCTORAL POSITIONMICROBIAL GENETICS

Available imnmediately to study conjugal DNA transfer-of broad host-range plasmids. Send curriculum vitae andnames of referees to: Dr. Richard Meyer, DepartmentofMicrobiology, ESB 226, University ofTexas, Aus-tin, TX 78712-1095.

Harvard Anaesthesia Center has several POSTDOC-TORAL POSMIIONS available in a team of biophysi-cists and molecular pharmacologists investigating themembrane actions ofanesthetics and neuromodulatorsinvolved in pain. Positions are: spectroscopic investiga-tions oflipid-protein interactions; rapid kinetic studies ofreceptor-mediated ion flux; electrophysioloRy of sodiumchannels; patch-clamp and biochemical studies in sensoryneurones; tachykinin receptor purification and character-ization; synthesis of novel compounds and membraneprobes. Appointments will be for 2 years initially. Start-mg date by negotiation. Interested applicants shouldcontact: Professor Keith W. Miller, Department ofAnesthesia, Harvard Medical School, MassachusettsGeneral Hospital, Boston, MA 02114. Tdelphone:617-726-8985. Equal Opportunity Employer.

1238

POSTDOCTORAL POSITIONSSeveral p doctoral positions are available immediate-

ly to study tumor suppressor genes and oncogenes inseveral types of cancer [Nature 329, 451 (1987)]. High-ly motivated candidates with a background in molecularbiology should submit curriculum vitae, a short state-ment of research experience, and names of three refer-ences to: Dr. Susan L Naylor or Dr. Alan Y. Sakagu-chi, Dertment of Cellular and Structural Biology,Uiversity of Texas Health Science Center, 7703Floyd Curl Drive, San Antonio, TX 78284.An Equal OpportunitylAffirmativeAcictn Employer.

POSTDOCTORAL POSITIONSCENTER FOR POSTDOCTORAL

TRAININGThe University of Oklahoma Health Sciences Center

campus is currently recruiting postdoctoral research fel-lows (M.D. and/or Ph.D.) in a variety of disciplines.Travel funds to visit the campus are available to selectedapplicants. Three NIH trasning grants support researchin clotting mechanisms, septic shock and tissue injury,and substance use and abuse. Positions are also availablein other excellent programs within individual labora-tories. The campus is well-equipped, active in research,and growing rapidly. For further information, sendcurriculum vitae and the names, addresses, and telephonenumbers of three references to: Dr. L. E. DcBault,Ccnter for Postdoctoral Training, P.O. Box 26901,Oklahoma City, OK 73190.An Equal OpportunitylAffirmativeAction Employer.

POSIDOCTORAL POSITIONS immediatelyavailable for developing invertebrate and vertebrate sys-tems to study effects ofxenobiotics on immune function.Preference will be given to applicants with backgroundsin immunology or toxicology and interest in invertebratephysiology. Send curriculum vitae and three letters ofrecommendation by 15 June 1988 to: Dr. A. J. Goven,Department of Biological Sciences, University ofNorth Tcxas, Denton, TX 76203.AnEqual Opportuni-tylAffirmativeAction Employer.

POSTDOCTORAL POSITIONS are available tocollaborate on studies examining the mechanisms ofoxidant-induced alterations in endotheial cell membranestructure and function. Positions are for 1 year beginning1 July 1988, and involve isolation of plasma membranelipids, preparation of liposomes, and measurement oftransiembrane transport and membrane biophysicalpropertics. Backround in membrane biology and tech-niques or lipid biochemistry is desired. Send curriculumvitae and names and telephone numbers of three refer-ences to: Dr. Edward R. Block, J. Hillis Miller HealthCenter, Box J-225, Univcrsity ofFlorida, Gainesville,FL 32610. Telephone: 904-374-6069.

POSTDOCTORAL POSMONSNew proecct involving cell biology, developmental

biology, and polymer chemistry with potential clinicalapplications in transplantation and regeneration.

Candidates to have experience in one or more of thefollowing areas: cell biology, developmental biology,hepatology, chemical engineerin, biomedical engineer-ing. Interested individuals should submit current curricu-lum vitae together with three references to one of thefollowing: Dr. Joseph P. Vacanti, Harvard MedicalSchool, The Chilcn's Hospital, 300 LongwoodAvenue, Fcgan 5, Boston, MA 02115 or ProfessorRobert S. Langer, De of Applied BiologicalSciences, M.I.T., 77 MassachusettsAvenuc, BuildingE-25, Cambridge, MA 02139. An Equal OpportunitlAffirxative Actin Employfr MIF.

POSTDOCTORAL POSITIONS available to studythe structure and function of muscle filaments andnuclear pore complexes. Experience in electron microsco-py and image processing is desirable. Salary: $18,000 to$22,000, depending on experience. Candidates whohave recently completed their Ph.D. thesis, or expect todo so soon, are particularly encouraged to apply. Sendcurriculum vitae and narnes of three references to: Dr.Ron Milligan, Department of Molecular Biology,MB14, Research Institute of Scripps Clinic, 10666North Torrey Pines Road, La Jolla, CA 92037.

The Center for Hemostasis and Thrombosis Research,New England Medical Center and Tufts UniversitySchool of Medicine, invites applications for POST-DOCTORAL POSITIONS in the area of molecularbiology, cell biology, protein biochemistry and immuno-chenustry of blood coagulation and of vascular biology.

Faculty interests include:B. C. Furie-Structure-function relationships of the

vitamin K-dependent blood coagulation proteins stud-ied by site-specific mutagenesis and expression of recom-binant proteins

B. FzuriePosttranslational processing of the vitaminK-dependent proteins; platelet membrane proteinsD. D. Wagncr-Endotheial cell biology; processing

and expression of adhesive glycoproteins and their recep-torsD. L. Diuguid-Structure-function relationships of

mutant blood-clotting proteins to determine the molecu-lar basis of hemophiliaThe Center is located in new laboratories and is well

equipped with instrumentation for protein sequencing,pepide and DNA synthesis and molecular modeling.Please reply to: Ms. Colleen Matan, Box 832, Tufts-New England Mcdical Center, 750 WashingtonStreet, Boston, MA 02111.

POSTDOCTORAL POSMIIONS IN BIOTECH-NOLOGY: An interdisciplinary program for develop-ment ofthe biotechnology ofbacterial redox enzymes hasbeen established at University ofCalifornia, Los Angeles(UCLA). The participating departments are chemicalengineering, biological chemistry and pharmacology.Individuals with doctoral degrees in the areas of bioor-

*c, bioinorganic, biochemistry, electrochemistry, cellbiology, and biochemical engineering are being sought.Interested persons should send resume including re-search directions, along with the names of three profes-sional references to: Professor Vincent L. Vilker,UCLA Chemical Engineerng Deparent, 405 Hil-gard, Los Angeles,CA 90024 1592. UCLA is anEqual Opportuntty/AffiinativeAction Employer.

TWO POSTDOCTORAL POSITIONS are avail-able in molecular neurobiology: One to study theGABA/benzodiazepine receptor with monoclonal anti-bodies and recombinant DNA techniques; and a secondone to study endogenous modulators of the GABA/benzodiazcpine receptor. A background in molecularbiology and/or biochemistry is desirable. Please sendcurriculum vitae and three letters of recommendation to:Dr. Angel L. de Blas, Department of Neurobiologyand Behavior, SUNY Stony Brook, Stony Brook, NY11794.

POSTDOCTORAL RESEARCH ASSOCIATEPosition available 1 September 1988 for individual

with a Ph.D. in biochemistry. Project concerns intracel-lular calcium regulation in neurons and includes a bio-chemical examination of calcium-binding properties ofneurofilaments. Applicants with experience in proteinisolation techniques preferred. Send curriculum vitae andnames of three references to: Dr. Ron Abercrombie,Department of Physiology, Emory University, Atlan-ta, GA 30322. An Affirnative ActionlEqual OpportunityEmtloyer.

POSTDOCTORAL RESEARCH ASSOCIATE.USDA-ARS, Kearmcysville, West Virginia. A position isavailable for a molecular biologist to participate in amultidisciplinary research effort (molecular biolo y, tis-sue culture, and plant breeding) to improve peach fruitquality through transfer of specific genes. The specificproject involves promoter characterization, vector con-struction and plant transformation experiments for in-creasing cytokinin levels in developing fruit. The Kear-neysvilce laboratory has all the necessary facilities and isconveniently located near Frederick, Maryland, andWashington D.C. This appointment is for up to 2 yearsand the salary is $27,172 (GS-11) or $32,567 (GS-12).For information on application procedures, contact:Alice MacNamara, 301-344-8560. Applications in re-sponse to this advertisement should be marked 8N022and sent to: Dr. Ann Callahan, USDA-ARS, Appala-chian Fruit Research Station, Route 2, Box 45,Kearnysville, WV 25430. Telephone: 304-725-3451.

SCIENCE, VOL. 240

POSITIONS OPEN POSITIONS OPEN

As a Vienna-based pharmaceutical research center, we represent an important element in the intemational drug-discovery effortof the SANDOZ group.

The main focus of our activities is preclinical research in:

IMMUNOSTIMULATION MONOCLONAL ANTIBODIES(cytokines and synthetic compounds) (especially for use in the treatment of tumours)

DERMATOLOGICAL PHARMACOLOGY ANTI-RETROVIRAL THERAPY

To initiate and supervise new research projects in these fields we are seelcing Ph. D. level

IMMUNOLOGISTS(with a background in cell biology)

DERMATOLOGISTS(with a background in cell biology, biochemistry or pharmacology)

VIROLOGISTS(with a background in molecular genetics or biochemistry)

GENE TECHNOLOGISTSThere are several openings on each of these disciplines. For some of the positions a solid medical background (MD) would be ad-

vantageous. ln addition, we also have a number of vacant positions for Ph. D. level

ORGANIC CHEMISTSThe challenging natureofthe scientific tasks calls forresearchers withan above-average level ofprofessional expertise. The flexibility

of our organisation enables us to employ scientists presently holding positions at different levels of responsibility.At present, Sandoz Research Institute has some 150 permanent scientific staff that are supplemented by graduate students, post-docsand visiting scientists. Another90persons areproviding thenecessary scientific, administrative andtechnical support. Provisionshavebeenmadeforanincreasingnumberofinteractions withuniversity groups occupying laboratories attheSandoz ResearchInstitute site.The institute provides an exellentphysical inrastructure including biohazard containmentunits and generous large animal quarters.

Vienna is acosmopolitancityoffering afascinatingrange ofcultural events and institutions as well as extensive opportunities for sportsand leisure time activities. In tenns of science, the city is attracting an increasing number of international enterprises involved in

molecular genetics and biotechnology.This development has led to an expansion of these disciplines at Vienna's universities. Anumber of the researchers of the SANDOZ

Research Institute hold lecture posts at these local universities while others lecture abroad.Opportunities for a fruitful, intellectually stimulating dialogue are further enhanced by close co-operation with several SANDOZ

research units and other leading scientific centers.If you find our offer attractive and have the necessary qualifications, please submit a written application and CV directlyto Dr. Peter Dukor, Managing Director and Head of Research at SANDOZ Forschungsinstitut, Brunner Strasse 59, A - 1235

Vienna,Austria.

AIuD

..__

27 MAY 19881239

L27 MAY I988 1239

Gastrointestinal DiseasesResearchThe Procter& Gamble Company in Cincinnati,Ohio, is seeking an entry-level Ph.D. physiolo-gist or microbiologist to study the host-parasiteinteraction for gastrointestinal (GI) infectiousdiseases. The individual will work in a GIrpcpnrrh dSrniin intnprpttpd in iindlprctznndincsiczorLamI gi5VuJv mmiZ1I3mu Iin uisMw1iuiiigthe mechanisms of bacterial pathogenesis.Preference will be given to individuals familiarwith in vitro and in vivo models to studymucus production. Good communicationskills and the desire to work in an interdisci-plinary environmentare also important require-ments. Postdoctoral experience is desirablebut not required. Applicants must be U.S.citizens or permanent residents. Send resumeand publication list to:

Dr. T.J. Logan, ManagerPh.D. RecruitingGI Disease Research Position, Box STHE PROCTER &,GAMBLE COMPANYMiami Valley LaboratoriesP.O. Box 398707Cincinnati, Ohio 45239-8707A4n Equal O/p1wrtunity f:mpl er

GastrointestinalResearchThe Procter& Gamble Company in Cincinnati,Ohio, is seeking an entry-level Ph.D. physiolo-gist, physical pharmacist, chemist, or chemicalengineer to work on drug delivery to the GItract The individual will work in a GI researchgroup with interest in drug/polymer inter-actions with mucosal surfaces. Preference willbe given to those familiar with gastric physi-ology models. Good communication skills andthe desire to work in an interdisciplinaryenvironment are also important requirements.Postdoctoral experience desirable but notrequired. Applicants must be U.S. citizens orpermanent residents. Send resume and publi-cation list to:

Dr. T.J. Logan, ManagerPh.D. RecruitingGI Research Position, Box STHE PROCTER& GAMBLE COMPANYMiami Valley LaboratoriesP.O. Box 398707Cincinnati, Ohio 45239-8707in f;quaulOpportuni(y Amplo!$'r

Ph.D. BIOCHEMISTh

MOLECULAR BIOLOGISLSBristol-Myers' Wallingford, Connecticut world headquarters for Phar-maceutical Resear and Development is a state-of-the-art multi-milliondollar setting. Our Department of Cardiovascular Research is seekinghighly qualifed Biochemists and Molecular Biologists at the Ph.D. 1eveltobecome part of the drug discovery research team in the atherosclerosisand thrombosis areas. Opportunities for professional and personalgrowth are exceptional.

AtherosderosisPh.D. in Biochemistry, Molecular Biology or related area. Training in LDLreceptors, growth factors, VLDL assembly, or apolipoprotein synthesis.Industrial experience helpful but not necessary.

ThrombosisPh.D. in Biochemistry, Pathology Molecular Biology or related area. Ex-perience in coagulation is desirable. Industrial experience helpful butnot necessary.

Successful candidates,will receive a highly competitive salary, outstan-ding benefits, and the opportunity to make an important contributionto a company that's committed to the future. To apply, please send yourresume to: BRISIOL-MYERS COMPANY, Phaceutical Research&Development Division, Attn: HR 8, P.O. Box 5100, 5 Research Parkway,Wailingford, CT 06492.

An Equal Opportunity Employer M/F/HIV

@Bristol-Myers CompanyExplore With Us.

Director,Hancock Instituteof Marine StudiesUniversity of Southern California

Applications are invited for the position of Director ofthe new Hancock Institute of Marine Studies (HIMS) atthe University of Southem Califomia.The HIMS con-solidates previously separate organizations of USC tofocus etorts in marine research.The Director will serve as the representative of theUniversity's Marine Programs and be responsible forresearch conducted in the Institute, University-widemarine projects, the Sea Grant program, and coordina-tion of research programs housed in several depart-ments. The HIMS Director will oversee the manage-ment of ship operations, the Catalina Marine ScienceCenter and other marine facilities.The successful candidate must have an outstandinginternational reputation as a scientist and a provenrecord as an administrator. The selectee will beexpected to provide imaginative leadership for currentand future programs and promote the national andinterational stature of the insfitute. The Directorshould have a successful record of research andteaching and qualification for appointment as a tenuredfaculty member in an appropriate department.Applications will be reviewed beginning Jan.1, 1988,and thereafter until the position is filled. Qualifiedpersons should send a statement of interest andprevious experience, curriculum vitae, and list ofreferences to Dr. Robert Friedheim, Chair, HIMSSearch Committee, University of Southem Califomia,Los Angeles, 90089-03411.Candidates are encouraged to apply regardless ofgeder or ethnic origin. The University of SouenCalifomia is an equal-opportunity/affirmative-actionemployer

ResearchScientistsStaff and Post-

DoctoralMERCK SHARP & DOHMEResearch Laboratories, theworld leader in pharmaceuticalresearch, has several positionsavailable at regular Staff andPost-Doctoral levels within theDepartment of Pharmacology.

M.D. or Ph.D.The selected candidate willconduct a broad range of ex-periments within our ongoingantithrombotic, anticoagulantand thrombolytic programs.Substantial experience with Invivo models of thrombosisalong with an advanced degreeare required.

Post-DoctoralFellowshipsPosition -1

Ph.D. In B cm ltrylBiochemicalPharmacology

The selected candidate willconduct research on the struc-ture and function of proteinscontaining beta-hydroxyl aspar-tyVasparaginyl residues and onthe characterization of the en-zyme systems responsible forthe hydroxylations. Experiencein protein chemistry, proteinpurification, arndor enzymologyis preferred.

PRsition -2Ph.D. Biochemistry/

Cell BiologyThe selected candidate willconduct research on proteinscontaining beta-hydroxy-aspartyl/asparaginyl residues.Specifically, this individualwould study both the regulationof the synthesis and processingof the proteins as well as theregulation of the extent ofhydroxylation of the proteins inseveral cell culture systems (en-dothelial, hepatoma, recombi-nant). Tissue/cell culture ex-perience is preferred.Excellent salary and benefitprograms accompany these po-sitions at our modern researchfacilities located 25 miles nor-thwest of Philadelphia.Please send resume with salaryrequirements to:

Manager, ResearchPersonnel W42-2

Merck Sharp & DohmeRese h LaboratoresWest Ptint, PA 19486EEOIAA/lH/Employer

SENIOR

SCIENTIST. offmann-La Roche is an established leader in the pharmaceuffcal

L .L and heafth care industry, with a strong commitment to bio-._technology. The Department of Molecular Genetics provides a

stimulating and highly collaborafive environment for basic and ap-plied research on prokaryotic and eukaryotic gene expression, lymphokines,cytokines, growth factors and their receptors, oncogenes and other areas withrelevance to human pharmaceuticals.

We are seeking a Senior Scientist to be responsible for an exploratory researchprogram specializing in, but not limited to, structure and function studies of cell sur-face receptors of eukaryotic cells. We are especially interested in a Scientist who hasexperience in the biochemical characterization of cell surface receptors, and is able toapply hybridoma technology, analytical protein characterization and cell biologytechniques in support of our long term goal of identifying and characterizing receptorswhich have relevance to human pharmaceuticals. Qualifications include aPhD in CellBiology, Biochemistry, Pharmacoloy or a related discipline, and a minimum of 2years of postdoctoral training. Expenence in characterization of cell surface receptorsor related proteins and hybridoma technology would be preferred.

We are c6nveniently located in a suburban setting 10 miles from New York City.We offer a very competitive compensation package, and a research environment thatencourages scientific growth and publication. For consideration, please send yourcurriculum vitae and a etter indicating past, current and future research interests, to:Mis Elenor M. Malone, DRtment R.C., Hoffmann-La Roche Inc, Nutoy, NewJere 8m71 We are an equal opportunity employer.

| @ Hoffmann-La RocheWorking Today For A Healthier Tomorrow

NATIONAL UNIVERSITY OF SINGAPOREDEPARTMENT OF ORTHOPAEDIC SURGERY

RESEARCH FELLOWApplications are invited for appointment as Research Fellow in the Depart-ment of Orthopaedic Surgery. Candidates should possess a PhD degree inBiochemistry and preferably have some research experience in biochemistryof soft tissues, cartilage and bone, quantitative morphometry and immuno-chemical work.The successful candidate will be required to assist in the running of thebiochemistry laboratory in the Department. The appointment may be for up tothree years at a time.Gross monthly emoluments will range from S$2979 to S$4779.(US$1 = S$2.00 approx.) The commencing salary is dependent upon thequalifications and experience of the appointee.Leave and medical benefits will be provided. Depending on the type ofcontract offered, other benefits may include: provident fund benefits or anend-of-contract gratuity, a settling-in allowance of S$1,000 or S$2,000,subsidised housing at nominal rentals ranging from S$100 to S$216 p.m.,education allowance for up to three children subject to a maximum ofS$10,000 per annum per child, passage assistance and baggage allowance forthe transportation of personal effects to Singapore.Candidates should write to the Director, Personnel Department, NationualUniversity of Singapore, 10 Kent Ridge Crescent, Singapore 0511, giving theircurriculum vitae and the names and addresses of three referees who cancomment on their research ability and/or professional competence.

J.0.

i

POSITIONS OPEN

POSTDOCTORAL RESEARCH ASSOCIATEpositions available in application oftechniques ofmolec-ular endocrinology to problems related to the biochemnis-try of reproduction. Currcnt project areas indudcrtor purification andcharactrzation, synthesis of -tides having functional properties, isolation of natulyoccurring gonadal paracrne factors, structure-functionstudies on glycoprotein hormones, and studies on signaltransduction and mechanism of hormone action usingcultured ccll systems as well as in vivo models. Salaricsarc neCtiabk and depend on qualifications and expen-ence. Send curriculum vitae and names of dtree refer-ences to: Dr. Leo E. Reichert, Jr., Department ofBiochemist, Albany Medical CoNlge, A , NY12208.An Affirmative ActionlEqual Employmcnt Opportunity

Employer.

POSTDOCTORAL RESEARCH FELLOWSTwo positions available 1 July 1988. One for the

characterization of lymphoid protein subsets associatedwith malignancy, and the other for the detection ofmutations in ymphoid cells resulting from exposure toradiation or chemotherapeutic agents. The Univrity ofMidian it an Equal OpportunitylAffirati Action Em-ploer. Send curriculum vitae to: Dr. Sam M. Hanash,Uniersity of Michigan Medical School, Departmentof Pediatrics, R4451 Kresge I, Box 0510, Ann Ar-bor, MI 48109-0510.

NATIONAL INSrITUTES OF HEALTHMOLECULAR BIOLOGY/TRANSGENIC MICE/ENDOCRINE DISEASES

POSTDOCTORAL RESEARCH POSITION forM.D., Ph.D., D.D.S., or equivalent, with traiiing inrecombinant DNA technology and construction of vec-tors to work on transgenic mice and endocrine diseases.Candidates with 1 or 2 years ofexperience preferred. Theinitial appointment will be for 2 years, with renewals on ayearly basis. Starting salary range, depcnding on experi-ence, is $20,000 to $46,000 per year. Must be U.S.citien. The position is available immediately. Sendcurriculum vitae and names of three references to: Dr.Lois Salman, Assistant Scientific Director, NationalInstitute of Dental Reserch, National Institutes ofHealth, Building 30, Room 131, Bethesda, MD20892.

NIH is an Equal Opportunity Employer.

POSTDOCTORATES IN PLANT BIOLOGYTwo positions availablc to study gencs/proteins in-

volved in the ubicuitin-dependent proteolytic pathwayof higher plants, inluding Ar . Expcnence inmokcular tcchniqucs and enzymology preferred; priorwork in plants unnecessary. Send r6sumc and names ofdtree references to: Dr. Rihard Vierstra, Departmentof Horticulture and Celular/Molecular Biofogy Pro-gram, University ofWisconsin, Madison, WI 53706.Telephone: 608-262-8215.

THE UNIVERSITY OF CHICAGOPROTEIN BIOCHEMIST

Excellent opportnity to work at The University ofChicago's newly created Protein Biochemistry Core Fa-cility. MS. in chemistry or biochemistry (B.S. will beconsidered). Prefer 1 to 2 years of protein sequencingand peptide synthesis. Salary ($22,500 to $30,000)

with skills plus fringe bencfits. Rcsponsi-bilities will indude protein sequencing, using spinningcup and gas phase protein sequencer, peptide synthesis

and amino acid analyscs. Director of facility will provide

some training. Close interaction with faculty and possible

personal advancement. Please send curriculum vitae and

dtree letters of recommendation to:

Stephen C. MeredithDepartmcnt of PathologyThe Univcrsity of Chicago

5841 South Maryland AvcnucChicago, IL 60637

The University ofChicago is an Equal OpportunityEmplyer

I242

Career Opportunities inThe Department of

-ORGANIC CHEMISTRYBURROUGHS WELLCOME CO., a progressive pharmaceutical company with a top rep-utation for research, has immediate need for scientists in the following areas:

Leader, NMR GroupResponsible for the NMR spectroscopy facilities, staff and their structural chemistrysupport functions for the primary and secondary structure determination of small to inter-mediate size organic molecules. This position requires a Ph.D. degree (or equivalent) inChemistry with acknowledged expertise as an NMR spectroscopist and with substantialtheoretical and working knowledge of modern 2D NMR techniques. Must have workingknowledge (as a hands-on problem solver) of NMR hardware and software. Must havedemonstrated ability as an administrator with good interpersonal and communicationskills. Previous experience with an understanding of special problems of NMR supportwork preferred.Physical Biochemist/BlophysllstTo support research for Wellcome Research Laboratories by the application of opticaland/or NMR spectroscopic techniques to the study of drug-membrane interactions, andto supply biostructural/biophysical support for Company research and problems relatedto products. Applicants must have an MI.S. degree in physical chemistry, biochemistry,or a related field, or equivalent experience/training. Familiarity and understanding ofmodern spectroscopic techniques is required.BURROUGHS WELLCOME CO. offers a competitive salary, a comprehensive companypaid benefit package, and a challenging environrent in which to apply your professionalcapabilities. Qualified Minority, Female, Veteran and Handicapped individuals are en-couraged to apply. T. .nl h nurri, am vAtsa with trnwrin* if avnil

ANIMAL SCIENCERESEARCH

SCIENTISToffmann-La Roche is a world-renowned company recog-nized for its strong commitment to research in animalagriculture, with ongoing investigations and discoveries

of new methods for altering and improving animal growthperformance.

Due to this commitment, we're seeking an individual to join ourAnimal Science Research Department to conduct research tocharacterize the effects of growth factors/analogs by bioassay. Toqualify, you'll need an MS in Biochemistry, Physiology or a relateddiscipline; demonstrated proficiency in cell culture techniques; and1-3+ years of experience in bioassay development (e.g. radio-immunoassay, receptor binding assay, automated assay procedures).

You'll enjoy the professional environment and challenges Rocheoffers, while receiving a highly competitive compensation package. Forconfidential consideration, please send your resume, indicating salaryhistory and requirements, to: Frances Newman, Department T.M.,Hodfmann-La Roche InL, NItley, New Jersey 07110. We are an equalopportunity employer.

@ Hoffmann-La RocheWorking Today For A Healthier Tomorrow.

Baxter...LEADING THE WAYBaxter Healthcare Corporation's record of

excellence encompasses over 30 years of com-mitment to technology, innovation and quality.Currently, our Hyland DMsion is seeking similarly-committed individuals to join its staff as ResearchScientist and Sr. Research Associate.

RESEARCH SCIENTISTThis individual will participate in pilot-scale

production and scale-up process of stroma-freemodified hemoglobin for therapeutic applica-tion; set up and operate the closed/asepticchemical reactor for modification of hemoglobin;and take part in development and applicationof analytical methods concerning the project.The selected candidate must be able to super-vise 1 -2 technical personnel and assistthe groupmanager in preparing technical documents. Re-quirements include an M.S. in Chemistry/Bio-chemistry, with 5 years of relevant industrialexperience or Ph.D. in Chemistry/Biochemistrywith 2 years of experience. Experience in bloodcomponent R&D and Production, along withtheoretical and practical knowledge of hemo-proteins in general and hemoglobin in particularis helpful. Any experience with immunoassaymethods and toxicity analysis techniques ispreferred.SR. RESEARCHASSOCIATEThe person selected for this position will set

up and operate a set of aseptic/closed processvessels and filtration/ultrafiltration systems andprepare pilot-scale amounts of stroma-free,modified human hemoglobin each month as afunction of scale-up process. He/she will also beresponsible for maintaining the sterility of thissystem and improvement of its overall efficiencyand further development.The selected individual will be required to

supervise 4 technical workers including assign-ing tasks, inspection and control, solving routineproblems by modification of equipment andmethodology. A B.S. in Chemical Engineering,Chemistry, or Biology plus 5 years of relevantindustrial experience or M.S. in Chemical Engi-neering, Chemistry, or Biology and 3 years ofexperience is mandatory. Background in prepara-tion of blood products and GMP is desirable.

Baxter offers the selected candidates afriendly, stable work environment with room togrow both personally and professionally, as wellas attractive benefits and compensation plans.For immediate consideration, please send a re-sume wfth salary history to: Baxler Hylnd Divi-sion, Ms. Vickie Thrasher, 4501 W. ColoradoBlvd., Los Angeles, CA90039. PRINICPALSONLY, PLEASE. Equal Opportunity Employer.

Hyland Division

Baxter

CSIROAUSTRALIA

I

Biochemical GeneticistSenior Research Scientist/Principal Research ScientistA$36,421 p.a. - A$49,256 p.a.Division of Fisheries Research

Marine Laboratories,HOBART, TASMANIA

FIELD: FShe Resear/Populatio getic

THE DIVISION: The Divisions Of Fis Research and oceanog-raphy coectively form the CSRO Marine Labatories, which isAustraia's principal marine research institution. The Division ofFiser Resech undertakes studies into the biology, ecology andpopaation dynaiics of marine populatiS (both plant and animal)and supplies informat on for the dev ent of managementstrategies for fshei win the Australian sing Zone. TheDvision currently employs about 140 staff of whom 80 areprofessional Cresh staff with its main laoratory in Hobart andsmaHer labtories in Perth and Brsbane. The Division charters a53m reSearCh veSSel whiCh is due for rep acement in 1989.

THE WORK: The Fiheies Resources programs of the Division are

cafried out around the continent (south and south-east fromHobart, north and north-east from Bribane, west and north-westfrom Perth). Current gmsindude studieson fish taxonomy,reproductive blogy, ecology, popultion dynamics, exploratoryfisng, stock assessmet and environmental protection. Fshene

under investigation indludethe south-east trawi (with spedal refer-ence to the orange roughy) scaops, nor multi-speces demer-salfshe, northern pagicfhiesandthesouthern bluefin tunait is expected that the Division wIN be carrying out exploratory anddevelomental work on the fiseies of the western and north-western deep water.

THE JOB: The appointee wiN plan and cary out research on the

population genetics of Australia's comrcI y exploitable fiseiesresourcs. Arrangements for support staff wiN be finalized afterdiscussios with the successful applicant. The rese will aim atcomplementing that of other research groups within the Division,and would be expected to provide input into prgrams examiningpronems of spedes identfcation, stock delimitation, stock recruit-ment elationships, and growth. The appointee would also beexpected to llaise with other groups and organiatlouls rsponsiblefor fisheies research and and to prepare colabora-

tive grant proposais aimed at solving fi iesm ms whichrelate to this field of expetise.

THE PERSON: Applicants should hold a PhD or equivalent qualifi-cations in genet with at least six years postdoctoral reseacexpernce in popuin genetics including at least five years infishie or wildlife researh togethr with dremontrable (throUghpublicatin) research ability. Sutably applicants of out-

standing calibre but with less relevant experience could be con-sdered for appointment at a lower level.

LOCATION: TheappointeewillbelocatedattheMarinelaboratoriesin Hobart.

CONDITIONS: Appointment will be for a term of three years withthe-possibiity of conversion to an indefinite appointment. Ausra-lian Govenment superanuation benefits are avaable.

MORE INOMATION: Prospective applicants are invited to tele-phone Dr P.C. Young (002) 20 6222 for further infmtin. A copy ofthe detailed job desipton and selection can be obtainedfrorM Mr L St George on (002) 20 6222.

APPLICATION: Applications should be submitted by 17 June 198and quoterefere number FC88/2. TheyShoUld be framd aganstthe seltion criteria and should state relevant pesonal partiars

induding detals of qualcations and experience. Applicants shoudnominate at least two referees, and address theirappiaons to

The ChiefCSIRO Division of RFises ResearchGPO Box 1538Hobart, Tasmania 7001 (Australia)

CSRO IS AN EQUAL OPPORTUNTY EMPLOYER I

SCHOOL OF MEDICINE

CHAIRMANBIOCHEMISTRY/MOLECULAR BIOLOGYThe University of Miami School of Medicine is seeking applications andnominations for the position of Profesor and Chairman of the Departmentof Biochemistry and Molecular Biology. The person filling this position willhave the unique opportunity to lead a well recognized and already estab-lished department and to greatly expand the department's capabilities in thearea of molecular biology. Funds for the development of the department areavailable through a generous award from the Lucille P. Markey CharitableTrust. In addition to funding the new chairman, these funds will be used tosupport multiple new investigators, as start-up funds for new equipment,and for the renovation of laboratories. Additional space will be provided in anew building currently under construction, to be completed by eariy 1989.The department includes 18 faculty members with full-time primary appoint-ments and a well-established graduate program with 35 trainees.The applicant must have a Ph.D., M.D., or equivalent degree, be intema-tionally recognized for contributions to molecular biological research, becommitted to educational activities, and clearly demonstrate leadership andadministrative capabilities. The successful candidate is expected to be anoutstanding scientist with an ongoing, independent and well-funded re-search program. This person will be expected to promote the molecular bio-logical research capabilities of the Department, the Medical School and theUniversity, to recruit outstanding scientists to the facuity, and to enhancethe teaching programs of the departments.Interested applicants should submit a curriculum vitae including the namesof 3 references to: Dr. James 0. Potter, Dept. of Pharmacology, Universityof Miami, P.O. Box 016169, MIami, FL 33101.An Equal Opportunity/Affirmative Action Employer.

SCIENTISTS AND ASSISTANTSCIENTISTS

PEPTIDE CHEMISTRY

BACHEM Bioscience, Inc. is the USsubsidiary of BACHEM Switzerland. We area young, dynamic and growing company; aleader in the field of biologically activepeptides. We are expanding our peptidechemistry group and have openings forScientists and Assistant Scientists in peptidechemistry.

Successful candidates must have a Ph.D.,M.S., or B.S. in peptide chemistry or a re-lated field with experience in solid phasesynthesis, purification and renaturation ofpeptides and proteins, HPLC, molecularmodeling and new drug design.

Interested candidates send their curriculumvitae with references and salary history to:

BACHEM Bioscience, Inc.3700 Market Street

Philadelphia, PA 19104

PUBLIC HEALTH SERVICESNATIONAL INSTITUTES OF HEALTH

NATIONAL INSTITUTE OF ENVIRONMENTALHEALTH SCIENCESSTAFF FELLOW

(Salary Range $20,000 - $38,753Less than 3 years postdoctoral research experience)

SENIOR STAFF FELLOW(Salary Range $24,000 - $43,452

3-7 years postdoctoral research experince)A postdoctoral position is available in the Yeast Genetics/Molecular Biology Group of the Cellular and Genetic ToxicologyBranch, Division of Toxicology Research and Testing, NIEHS,located in Research Triangle Park, North Carolina. The activitiesofthe Group are directed towards understanding mechanisms orrepair, recombination, mutagenesis, chromosome distributionand consequences of external perturbations. Selectee will partici-pate in ongoing programs directed at studying various aspects ofchromosomal metabolism in mitotic and meiotic cells, primarilyyeast, and will also develop an independent research program.The initial appointment is for two years, with additional

extensions possible for talented researcher. Applicants shouldpossess a record of demonstrated research productivity, theability to carry out both independent and collaborative researchand a Ph.D. or equivalent degree and postdoctoral experience inGenetics, Molecular Biology, Biochemistry or closely relatedfield. Should be U.S. Citizen.

For additional information contact Johnny McLean or EmilyStarnes at 919-541-7513. To apply, send curriculum vitae andthe names of three references by 6/24/88 to:

Johnny L. McLean (Code HNV56)NIEHS Personnel OfficeP.O. Box 12233Research Triangle Park, NC 27709

AN EQUAL OPPORTUNITY EMPLOYER

THE STATE UNIVERSITY OF NEWJERSEY

RUTGERSDEPARTMENT OF BIOLOGICAL SCIENCES

FACULTY POSITIONSThe Department of Biological Sciences, Rutgers University invites applicationsfor three tenure-track faculty positions at the level of assistant or associateprofessor.These positions represent the continuing development wifthin ourfaculty of a strong integrated research concentration in cellular and molecularbiology. The details of these positions are as follows:CELL BIOLOGY. We seek a scientist with research interests and experience inthe molecular genetics and biochemistry of eukaryotic cells. The successfulcandidate will join a strong nucleus of cell biologists already within theDepartment and University. (Dr. Alice Liu, Search Committee Chairperson).MAMMALIAN CELLULAR/MOLECULAR BIOLOGIST. A position is available forsomeone desiring to pursue a research program involving molecular/biochem-ical studies on the regulation of gene expresison in mammalian cells, witha focus on functions implicated in transformation, proliferation, metas-tasis or cell-cycle phenomena (Dr. David Denhardt, Search Commit-tee Chairperson).DEVELOPMENTAL NEUROBIOLOGY OR DEVELOPMAENTAL GENETICS. We areparticulariy interested in individuals using molecular and cellular approachesas applied to the areas of developmental neurobiology and/or the geneticregulation of development. Other areas of modem development biology willalso be considered. (Dr. Howard Passmore, Search Committee Chair-person).The successful candidates for these positions will be expected to develop andsustain a strong research program and to contribute to departmental teaching.Terms of appointment are competitive and will provide an excellent opportuni-ty to develop an independent research program. The positions will be availableas of January 1, 1989 with flexibility in the actual start date of appointment.Send curriculum vitae, a description of research interests, and the names of itleast three references to the chairperson of the appropriate search committeeas listed above, PO Box 1059, Piscataway, NJ, 08855.

Rutgers is an equal opportunity/affirmadve action employer.

The Investigative Toxicology and Immunology and Antiinfecies TherapyDepartments of Smith Kline & French Laboratories, loated in suburbanPhiladelphia, are seeking a Postdoctoral Scientist to conduct quantitativecytometry on proliferative rodent lesions and to study the molecularmechanisms involved in the formation of these lesions. The appointment isfor one year, renewable for a second year on mutual agreement.The successful candidate will:* correlate DNA content (ploidy) as measured by adherent cell cytometry

and flow cytometry with the proliferative activity of rodent lesions asdetermined by histologic and morphometric criteria.

* compare oncogene expression of spontaneous and drug-inducedproliferative rodent lesions.

* study the intracellular oncoprotein distribution in tissue sectionsprepared from prolferative rodent lesions.

Candidates should have:* Ph.D. in Cell Biology or related discpline with 0-3 years postdoctoral

experience.* Knowledge of quantitative cytometry and molecular biology.* Excellent verbal and written communication skills.We offer an excellent compensation, benefits and relocation package aswell as opportunities for personal and professional growth. Please forwardyour C.V. and the names of three references to: Marianne J. Shandy-C0048, Smith Kline & Frencb Laboratories, Research & Development, P.O.Box 1539, King of Prussia, PA 19406-0939. We are an Equal OpportunityEmployer, M/F/H/V.

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THE

SCiENCERECRUITMENT

"FOUR DAY CLOSE"NOW YOU CAN SEE YOUR AD IN SCiENCE

FOUR DAYS AFTER SUBMISSIONScientific Recruiters can now advertise positions almost as soon as the need arises. Instead of reserving space a month or more inadvance, you can now place your ad four days before the magazine mailing date. Science is mailed on the cover date.

Film (right-reading, emulsion face down) or full camera ready art and insertion order must reach:SCiENcE, Short Close Desk, 1515Broadway, New York, NY 10036 by NOON Mondays (except for legal holidays when material must reach New York by Noon Fridays).Because space is limited, the four-day close page will be reserved on a first-come, first-served basis, at a 15% premium. 1/4 and 1/2page ads only.

Now you don't have to wait to find the researchers you need immediately, nor must you advertise in a Sunday paper that pans a lot ofsand, but not much gold. Scientific employers know that SCIENCE ads fill the job better. Now they fill it faster too.

You can call it INSTANT RECRUITMENrT

For further information, telephone Ed. Keller, Recruitment Advertising Manager, or Donna Rivera, Production Manager at SCIENCE:212-730-1050, or write to: SCiENCE, 1515 Broadway, NY, NY 10036.

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O s( I

CASE WESTERN RESERVE UNIVERSITYDean of Mathematics and Natural SciencesCase Western Reserve University invites nominations and applications forthe position of Dean of Mathematics and Natural Sciences. This is a newposition, currently filled by an interim appointee. A permanent appoint-ment will be made as soon as the search process reaches a conclusion.The Dean will be responsible for providing academic leadership for thefaculty of Mathematics and Natural Sciences, and for developing the faculty,staff, and financial resources needed to sustain high standards in teaching,research, and scholarship. Specific responsibilities include review of allrecommendations for appointment, promotion, and tenure, with an activerole in faculty recruitment; establishment and management of expensebudgets for the Mathematics and Natural Sciences departments within theoverall budgetary framework of the Colleges; development of curricularand research initiatives; program planning and evaluation; and activeparticipation in fund-raising and strategic planning. The Dean reportsadministratively to the Dean of the Colleges, but coordinates as wellwith the Provost and the deans of the professional schools on a number ofacademic matters.The faculty of Mathematics and Natural Sciences consists of 90 full-timefaculty in departments of Astronomy, Biology, Chemistry, Geological Sci-ences, Mathematics and Statistics, and Physics. A successful candidateshould hold a terminal degree in one of these disciplines and be eligible for asenior, tenured faculty appointment. Other qualifications include a suc-cessful record of achievement in teaching, research, and administration,with a demonstrated commitment to excellence. Applicants should send aletter of interest, along with a current curriculum vitae and the names ofthree or more references, to: Search Advisory Committee for the Dean ofMathematics and Natural Sciences* c/o Vice President Richard E. Baznik*Case Western Reserve University * Adelbert Hall, Room 26 * Cleveland,OH 44106.

Review of candidates will begin immediately, although applications andnominations will be received until the position is filled.In employment, as in education, Case Western Reserve University is committed to equalopportunity and affirmative action.

U.S. Department of Energy

POSTGRADUATERESEARCH PROGRAMSToxicologyFossil EnergyHazardous WastesEconomics/Energy Policy

ArtificialIntelligence

EngineeringPhysical SciencesEnvironmentalSciences

Life SciencesComputer Sciences

*Research at national laboratories* Stipends $ 19-35,000 depending on

degree, program, research area*Recent graduate degree*U.S. citizens or PRAs eligible* Information

Postgraduate Research ProgramsE¶i30 University Programs Division

Oak Ridge Associated Universitiesg&II1 P.O. Box 117

Oak Ridge, TN 37831-0117(615) 576-3190

!@ OKLAHOMAMEDICALRESEARCHFOUNDATION

Postdoctoral fellowship positions are available in the CardiovascularBiology Research Program at the Oklahoma Medical Research Foun-dation. The program centers on cell-mediated events that regulateblood coagulation with emphasis on inflammatory mediators Amultidisciplinary approach is available that provides experience in oneor more of the following areas: protein chemistry, physical chemistry,physiology, molecular biology, and the cell biology of platelets andendothelial cells. Fellows are encouraged to participate in collabora-tive projects within the group. The laboratories are located in a newbuilding with excellent facilities. Core services include peptide andoligonucleotide synthesis, gas phase microsequencing, direct access toa VAX computer network for analysis of DNA and protein sequences,molecular graphics, fluorescence imaging and spectroscopy, scanningand reaction titration calorimetry, endothelial and hybridoma cellculture laboratories, electron microscopy, and flow cytometry. Posi-tions are currently available with Drs. Philip Comp, Charles andNaomi Esmon, Rodger McEver, Peter Sims, Fletcher Taylor,or Therese Wiedmer. Applicants should send C.V.s and referencesto any of the above investigators at the

Cardiovascular Biology Researh ProgramOklahoma Medical Research Foundation825 N.E. 13th St.Oklahoma City, OK 73014.

OMRF is a private, non-profit, equal opportunity employer locatedadjacent to the University of Oklahoma Health Sciences CenterSalaries are competitive and commensurate with experience.

BUILDING ANEW LAB?

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SCIENCE MAGAZINENEW LAB SERVICE DEPT.1515 BROADWAYNEW YORK, N.Y. 10036

ADVANCEDLIGHT SOURCE

Lawrence Berkeley LaboratoryCall for Letters of InterestThe Advanced Light Source, a national user facility at the LawrenceBerkeley Laboratory for the production of high-brightness, partiallycoherent X-ray. and ultraviolet (XUV) synchrotron radiation, is sche-duled to begin serving users in the fall of 1992.

LBL is now seeking initial expressions of interest from users who planto participate in the instrumentation of ALS beamlines as members of:

* An Insertion- Device Team (IDT)* A Bending-Magnet Team (BMT)

Letters of interest are encouraged from:

* Groups of Scientists* Institutions* Individual Scientists

LBL will be pleased to assist in the formation of multi-institutionalgroups in various areas of research by matching scientists with likeinterests.

The earliest beamline decisions will be made by September 1, 1988.Those who wish to submit letters of interest should write to:

Arthur L. Robinson, Assistant Scientific DirectorAdvanced Light Source80-101# 1 Cyclotron RoadBerkeley, CA 94720

LAWRENCEBERKELEYLABORATORY

)

P.I .

POSITIONS OPEN

RESEARCH ASSISTANT-MOLECULAR NEUROBIOLOGY

The Jackson Laboratory, a center for mammaliangenetics research located on the coast of Maine, has animmediate opening for a research assistant with an M.S./M.A. in the biological sciences or a B.S./B.A. withrelevant experience. This position offers an opportunityfor active and original participation in a research pro-gram directed at understanding the roles of specific celladhesion molecules and the genes which encode them, innormal and abnormal deve[opment of the nervous sys-tem. Laboratory duties include DNA/RNA preparations,Southern/Northern/in situ hybridization, gene cloning inexpression vectors, and tissue culture. Please send curnc-ulum vitae, transcripts, and three letters of reference to:Harold Wheeler, Employment Manager, The JacksonLaboratory, 600 Main Street, Bar Harbor, ME04609. Telephone: 207-288-3371. Affirmative Action!Equal Opportunity EmployctrMiF.

RESEARCH ASSISTANTResearch assistant professor for Basic Science Research

in Surgical Research Laboratory. Requirements shouldinclude previous experience in research laboratory, M.D.or Ph.D. degree m pharmacology. Send resume to:Clinical Business Manager, Box 181, Department ofSurgery, University of Virginia Medical Center,Charlottesville, VA 22908.An Equal OpportunitylAffir-mativeActon Emplyer.

RESEARCH ASSOCIATEThe Department of Pharmacology, SUNY/Health Sci-

ence Center at Syracuse wishes to hire an M.D. or Ph.D.with experience in nonlinear dynamics and cellular andsubcellular cardiac electrophysiology. One goal is tostudy dynarnically complex arrhythmias and rate-depen-dent block processes in heart tissuesin n experiments andcomputer simulations. Background in nonlinear mathe-matics and chaos theory as well as experience withelectronics and computer hardware and software arerequired. Please send complete curriculum vitae and listofthree references to: Dr. Donald C. Michaels, Depart-ment of Pharmacology, SUNY/Health Science Cen-ter, 766 Irving Avenue, Syracuse, NY 13210. AnEqual OpportunitylAffirmative Action Employer.

RESEARCH ASSOCIATEThe Laboratory ofGenetics, The Rockefeller Universi-

ty, solicits applications for the position of researchassociate.Applicants must have a Ph.D. in molecularbiology anda minimum of 4 years of postdoctoralexpenence with the molecular biology of Drosophilaneurogenesis. A strong record of publications in this areais necessary to demonstrate potential for independentresearch. The successful applicant will also participate inongoing projects involving receptor protein biochemis-try. One to 2 years of experience in this area is alsorequired. Competitive salary and benefits are available.For consideration send curriculum vitae and the name ofthree references to: Dr. Michael Young, Thc Rockefel-ler University, 1230 York Avenue, Ncw York, NY10021. An Equal Opportunity Employer.

RESEARCH ASSOCIATE: Developmental neurobi-ology laboratory in university-affiliated institute seeksPh.D. with ecperience in biochemistry/molecular biologyto work on neural growth factors and related problems.Opporunity for independent program development.Send curriculum vitae and narnes of three references to:Dr. Emanuel D. Pollack, Institutc for the Study ofDevelopmental Disabilities, 1640 West RooseveltRoad, Chicago, IL 60608. An Equal OpportunitylAf-firmative Action Employer.

RESEARCH ASSOCIATE AND POSTDOC-TORAL FELLOW with experience in molecular biolo-gy and nucleic acid biochemistry are needed for researchon molecular mechanisms of mutation using purifiedreplication proteins. Send applications to: Dr. NavinSinha, Waksman Institute, Rutgers-The State Uni-versity ofNcw Jcrsey, P.O. Box 759, Piscataway, NJ08855. Rute is an Equal Opportunity/Affirmative Ac-tion Employer.

RESEARCH ASSOCIATE/STATISTICIANApplications sought for a research associate/statistician

(nontenure-track) in the College of Pharmacy and Phar-maceutical Sciences, Florida A&M University. This posi-tion will be filled as soon as possible. Applicants musthave a Ph.D. in statistics with experience in experimentaldesign, research methodology, and statistical evaluation.The successful applicant will be expected to establish his/her research program through competitive grants; toprovide instruction in statistics for professional andgraduate students; and to assist in strengthening grantproposals. The salary of this position is competitive.

Please submit curriculum vitae and three letters ofrecommendation no later than 30 July 1988 to: Dr. J. L.Early, Dean, College of Pharmacy and Pharmaccuti-cal Sciences, Florida A&M University, Tallahassee,FL 32307.

FloridaA&M University is an Equal OpportunitylEqualAccess University.

RESEARCH ASSOCIATE IINarragansett Bay Project GIS Applications Manager.

Ground Water Resource GIS Applications Manager.Two positions are available in coordinating applicationfor the Rhode Island Geographic Information SystemsProject. The Ground Water Resource GIS ApplicationsManager (190277) will be responsible for conductingGIS analys in ground water mapping and protectionfor the State of Rhode Island. The Narragansett BayProject GIS Applications Manager (190274) will beresponsible for conducting GIS analyses for NarragansettB Project scientists and policy analysts. Both positionswl work at the Environmental Data Center in theDepartment of Natural Resources Science. Applicantsmust have a Master's degree, 2 to 3 years ofexpenence ina field relevant to the position and experience in Geo-graphic Information Systems. Funding for both posi-tions is available until 1 October 1990. Applicantsshould send a letter of application, resume and thenames, addresses, and telephone numbers of three refer-ences by 10 June 1988, to: Dr. Peter August, SearchCoordinator, Research Associate II (Ground Water190277) Position or Research Associate II (Narra-gansett Bay Project 190274) Position, The Universityof Rhode Island, P.O. Box G, Kingston, RI 02881.An Affimative ActionlEqual Opportunsty Employer.

RESEARCH INSTRUCTOR/RESEARCH AS-SISTANT PROFESSOR-The Division of Cardiovas-cular Disease seeks an applicant for a non-tenure trackpoition to participate (i) in the training of cardiologyfcllows in molecular biological approaches and tech-niques and (ii) in an ongoing research program to studythe regulation ofcontractile protein genes. The successfulapplicant will have the opportunity to develop an inde-pendent research project in the future. A Ph.D. in ab>iological science and postdoctoral experience in molecu-lar biology required. Salary is commensurate with experi-ence. POSTDOCTORAL POSITION-available forPh.D. in biochemistry/molecular biology/or cell biologyinterested in studying the structure and function ofmyofibrillar proteins, and the regulatory mechanismsdirecting expression ofthose genes m cardiac and skeletalmuscles. Experience with protein purification, tissueculture, and molecular biological approaches and tech-niques desirable. Send curriculum vitae and names oftworeferences to: Dr. Patrick Umeda, University of Ala-bama at Birmingh, Division of CardiovascularDisease, Room 311 THT, UAB Station, Birming-ham, AL 35294. An Equal OppotunitylAffimative Ac-tion Employer.

RESEARCH INVESTIGATOR AND POST-DOCTORAL FELLOW-The positions are availableimmediately to study the structure and hormonal controlof eukaryotic genes. Applicants must have a Ph.D. or anM.D. degree with training in reproductive endocrinol-ogy and experience with recombinant DNA or proteinpurification techniques. Minimum of 3 years of postdoc-toral training in molecular biology is required for theResearch Investigator's position. Send curriculum vitaeand the names of three references to: Dr. Olli A. Janne,Associate Division Director, Center for BiomedicalResearch, The Population Council, 1230 York Ave-nue, Ncw York, NY 10021.

RESEARLCH MANAGERCOMPUTER SIMULATION/

TOXICOLOGYNorthrop Services Inc-Environmental Sciences has an

immediate opening for an individual to lead a researchgroup (three Ph.D's, four B.Sc.'s) developing biological-ly-structured computer simulation models for use intoxicological research and testing at their Toxic HazardsResearch Unit in Dayton, Ohio. Laboratory validationstudies are a significant part of the overall effort. Thesuccessful candidate will have a documented record ofresearch accomplishments with experience in computersimulation and research management.

Interested individuals should send curriculum vitaetogether with names and addresses ofthree references to:

Ms. Lois DoncasterHuman Resources

Northrop Services, Inc.Environmental Scienccs

101 Woodman Drive, Suite 12Dayton, OH 45431

Northrop Services, Inc. is an Equal Opportunity Eploycr.

RESEARCH MICROBIOLOGIST(BIOCHEMISTRY/GENETICS)GS-13 $39,501 to $51,354

A position is available at the U.S. EnvironmentalProtection Agency (EPA) Environmental Research Lab-oratory in Gulf Breeze, Florida, for a Ph.D. researchmicrobiologist specializing in microbial biochemistryand genetics and responsible for coordinating and super-vising research in the biodegradation of pollutants andhazardous wastes. Qualified individuals should have ex-pertise in biodegradation and have familiarity with mi-crobial enrichment techiques, gene and plasmid transfer,mechanisms of gene regulation and elucidation of meta-bolic pathways.EPA is an Equal Opportunity Employer. Applicants must

be U.S. citizens. Send a completed Federal StandardForm 171 (available from Federal offices and curriculumvitae postmarked by 8 July 1988 to:

EPA Personnel OfficeP.O. Box 98516

Las Vegas, NV 89193-8516

RESEARCH OPPORTUNIIES-Postdoctoralfellow-research technician: The Molecular Biology ofRetroviruses Research Laboratory at the Sloan-KetteringInstitute seeks additional staff personnel to participate ina series of immuno-related projects. Prior training andexperience in cell and tissue culture techniques, immuno-logic assays, and/or mouse tumor biology is essential. Ifinterested, please submit resume or curriculum vitae to:Mr. E. L. Kleinert, Employment Department #553,Memorial Sloan-Kcttering Cancer Ccnter, 1275 YorkAvenuc, Ncw York, NY 10021. Equal OpportunityEmployer, MIFIHIV.

RESEARCH SCIENTIST-Ph.D. (chemistry, bio-chemistry or pharmacology) sought to organize andoperate the biochemical and pharmacological laboratoryof the Departmnent of Anesthesiology. Highly collabora-tive individual needed with good supervisory skills.Knowledge of and experience with assays for musclerelaxants, narcotics, hormones (especially catechol-amines), substrates and nitrogen balance. Experiencewith HPLC, TLC, GC, and RIA. Candidate's area ofresearch and publications would be in pharmacokinetics,pharmacodynamics or muscle relaxants and narcotics,substrates and hormonal responses to surgical stress andrelated arcas. Apply with curriculum vitae to: Dr. Rich-ard Matteo, Departent of Anesthesiology, Colum-bia University College of Physicians andnSurgeons,P & S Box 46, Ncw York, NY 10032.

RESEARCH SCIENTIST to conduct drug studiesin cancer research. Advanced degree in biochemistry/pharmacology required, as well as 3 years of experiencem the following: drug metabolism, mechanism of action,analyzing drugs using high performance liquid chro-matographic, flow cytometric, and enzymatic techniques.Salary: $22,000 per year; 40 hours per week. Contact:Ihe Job Service at P.O. Box 82, Wimston-Salem, NC27102 or the Job Service office ncarest you. Refer toJob Order Number NC 7904106.

SCIENCE, VOL. 240

POSITIONS OPEN POSITIONS OPEN

Glaxo Inc. is not only one of the Top 10 ethicalpharmaceuticalfirms in America, we're also thefastest growing researcb-oriented company in thecountry. As sucb, we can offer exceptional careeropportunities, state-of-the-artfacilities, and afirm commitment toproducing the most effectivepharmaceuticals that experience, imagination,and advanced technology can create. join Glaxo,and apply your knowledge and career ambitionswbere tbey'll do you the mostgood.We currently bave thefollowing positionavailable at our Corporate Headquarters locatedin Research 7Mfangle Park, N. C.

RESEARCH GROUP LEADERNew Product Development

Witbin our Clinical Pbarmacokinetics/Bioanaly-tical Department, thisperson will be responsiblefor a metbods developmentgroup wbicbconcentrates on improving and establishingbioanalytical procedures to use on marketed andnew cbemical entitiesfrom Glaxo Researcb andtransferring these new metbods to analysts wbicbsupport the Clinical Development and Researcbprogram. Wbile supervising 2-3 researcbscientists on independent researcb based ormetbod developmentprojects, this individual willassist in problem-solving cbromatograpbicproblems involving metbod development andstudyproper analysis projects.Background must include a Ph.D. in AnalyticalCbemistry or a related area witb 3-5 years'experience in thepharmaceutical industry oracademia. A strong cbromatography backgroundwitb excellentproblem solving skills are required,as well as experience witb a variety ofcbromatography techniques (e.g. EC/LC, HPTLC,GC, GC/MS and RIA). Computer literacy usingmicro and mainframes and experience usingvarious data acquisition systems (MAXIMA,NELSON, LAS, etc) and software is required.At Glaxo Inc., growtb opportunities and up-to-date facilities are complemented by a location(near Raleigb/Durham) that bas excellentresources in closeproximity. Prestigiousuniversities, scenic vistas, lively recreationalareas, and exciting cultural opportunities are allapart of the daily life of the Glaxo professional.Furtber, we reward talent and creativity witb anexcellent salary and benefitspackage (includinga completely equipped, on -site atbletic facility).Candidates interested in this position, please sendresume including salary bistory, to:Human Resources DepartmentJob #8620X830

P0 Box 13398Research Triangle Ptrk, N.C. 27709

(No Phonc (.'alLs. Plca.-_t-)No Prn;we Ajcny Rrfcrr2l.-i Pka.z_

An Eq.ual (Opprfunitay Empk!cr M/F/H/V -/ _

Paving the way to a healthier world.

JPULNASA VISITINGSENIOR SCIENTISTSSPACE PHYSICS DIVISION

The Jet Propulsion Laboratory invites applications to itsVisiting Senior Scientist Program in the following areas:

Ionospheric and Magnetospheric PhysicsWe are accepting applications for senior scientists in the areaof magnetospheric and/or ionospheric physics to serve asDiscipline Scientists at NASA Headquarters in Washington,D.C. The successful applicants will be involved in the formu-lation of strategies and implementation of plans and pro-grams for the recently formed Space Physics Division, whichincludes branches in both ionospheric and magnetosphericphysics.These branches cover the areas of solar-terrestrial and spaceplasma physics, including activities in the U.S. as well ascollaborations with international organizations. Currentbranch responsibilities include oversight of Research andAnalysis Programs, operating satellites (San Marco, Intema-tional Cometary Explorer, Dynamics Explorer, AMPTE/CCEand IMP-8), the Sounding Rocket Program, and programs inplanning including the Intemational Solar-Terrestrial PhysicsProgram (ISTP) and use of the Space Station. A PhD (orequivalent research experience) in space plasma physics or aclosely related discipline with 3 years' experience in a NASAsponsored research program is required. For more informa-tion about the scope of the program and position responsibil-ities, contact Dr. Stanley D. Shawhan, (202) 453-1676. Dead-line for application is July 15, 1988. Refer to Dept. U60.

Solar Physics BranchThe Space Physics Division at NASA headquarters is seekingan individual with a background in solar physics to aid in thedevelopment and coordination of the NASA solar physicsresearch and technology efforts. NASA's solar program ad-dresses all aspects of contemporary solar physics, rangingfrom the Sun as a representative star to the Sun as the objectthat generates the Earth's space environment as well as thedevelopment of advanced instrumentation for space andballoon-bome solar missions.

As a Staff Scientist in the Solar Physics Branch at NASAHeadquarters, the incumbent will provide lead responsibilityfor the administration of the Solar Physics Supporting Re-search and Technology, Data Analysis, and Suborbital Pro-grams. In addition, the incumbent will serve as a recognizedexpert in solar physics for the structuring of NASA programs,and in relating those programs to not only the overall needsof the U.S. scientific community but to those of collaboratingforeign nations as well. Frequent travel and residence in theWashington, D.C. area will be required. This position is openfor immediate filling. Refer to Dept. U56.

Tenured faculty members are the preferred choice althoughqualified individuals from non-profit research institutions mayalso be considered. Normal assignment in the Visiting SeniorScientist Program does not exceed two years. Appointeesmust be U.S. Citizens or Permanent Residents and are expect-ed to return to their home institution following the NASAassignment. Please provide curriculum vitae, bibliographyand the names of four references, indicating area of interestand departnent number, to:

Dr. Harry Ashkenas 180-900Jet Proppulsion Laboratory4800 Oak Grove DrivePasadena, California 91109(8181 354-8251

An Equal Opportunity Employer

M-

La

POSITIONS OPEN

SENIOR SCIENTISTSSandoz Crop Protection is seeking a Ph.D. biochem-

ist, preferably with postdoctoral experience, in the area ofpptide/protein iso ation and sequencing. Preference will

given to applicants with experience in microisolationof neuropeptides. Background in other aspects of pep-tide/protein biochemistry, such as processing, transport,or metabolism are also desirable. For considerationplease send your curriculum vitae and letter of interest to:Sandoz Crop Protection Corporation, Zoecon Re-search Institute, Human Rcsources Department, 975California Avenue, Palo Alto, CA 94304-1104. Af-firmative AationEqual Opportunity Employer.

SUPERVISORY NEUROSCIENTISTThe U.S. Arny Medical Research Institute of Chemi-

cal Defensc is secking a neuroscientist, GM-14, (physiol-ogist, pharmacologist, or psychologist) to serve as Chiefof the Ncurotoxicology Branch, Pathophysiology Divi-sion. Rcsponsibilities includc planning and supervisingthe rcsearch programs and research assignments offifteento twenty civilian and military personnel and contractorsconcerned with investigations of the mechanisms ofaction on neural substrates of chemical agents, such asanticholincsterase inhibitors, and/or neurotoxic threatagents. The goal of these research initiatives will be thedevelopment of effective medical treatment regimens forthreat agents. Qualified applicants should have an exten-sive and varied professional background in electrophysi-ology, neuroanatomy, neurophysiology, neuropharma-cology, statistics, biophysics, computers, experimentalpsychology and neurotoxicology as well as experience in

multidiscpinary research program planning and admin-istration. The ideal candidate will have a Ph.D. in one ofthe basic animal sciences, physiology, pharmacology,psychology, or a dosely related discipline. Salary range:$46,000 to $60,000. U.S. cizensht is required and mustbc abk to obtain a security clearance. Send resumes by 1July 1988 to: Commander, U.S. Army AberdeenPro Ground. Attention: STEAP-PA-CR-D (Ms.Bynum), Aberdeen Proving Ground, MD 21005-5001. Equal Opportuni;ty Employer.

PRE-ANNOUNCEMENT-UNIT LEADER

This is a pre-announcement for the position of unitleader at the Texas Cooperative Fish and Wildlife Re-search Unit. The position will be announced through theOffice of Personnel Management. Expertise is desirablein one of the following fields: Fisheries ecology andmanagement, aquatic ecology (limnology, aquatic con-taninants, etc.), predator/furbearer ecology and manage-mcnt, or endangered species ecology. The unit leader(with extensive experience beyond the Ph.D.) guides anddirects an intensive multidisciplinary program ofresearchand graduate training with one assistant leader in fisher-ics science and one assistant lcader in wildlife science.The leader will also be expected to teach one course peryear and preparc refereed publications. The applicationperiod will be only 5 days. Therefore, pleasc have anupdated SF-171 prepared to send to the appropriateOPM Office. Applicants should send curriculum vitae,three lettcrs of recommendation, and a cover letterdetailing specific qualifications for this position to: Dr.Henry A. Wright, Department ofRange and WildlifeManagement, Tcxas Tech University, Lubbock, TX7940. Telephone: 806-742-2481.

VERTEBRATE BIOLOGY: Cumberland College aprivate, church-related, liberal arts college, invites appli-cations for a tenure-track position to begin in August1988. Courses taught will include comparative vertebrateanatomy, vertebrate field biology, comparative physiolo-gy, and human anatomy and physiology as well asreeshman-level general biology. Special topics courses inarea of interest may be developed. This position requiresa strong commitment to undergraduate education. It iscxpected that the individual, in addition to classroomteaching and student advising, will exhibit continuedprofessional growth. Ph.D. required. Send Ictter ofapplication, curriculum vitae, copics of transcripts, state-mcnt of teaching philosophy, and three letters of refer-ence to: Dr. Joseph E. Early, Academic Dean, Cum-berland College, Williamsg, KY 40769. Deadline:10 June 1988.

I250

POSITIONS OPEN

TEACHBING POSMONS INBIOLOGY AND PHYSICS

ILLINOIS MATHEMATICS ANDSCIENCE ACADEMY

-A Pioneering Educational Community"Biology-Two Positions. Each individual must be able

to teach a college-level general biology course as well asone or two of the three elective courses Ecology, Intro-ductory Genetics, and Human Biology. Knowledge ofmolecular/cell biology would be helpful.

Physics. Must be able to teach an algebra-based collegelevel general physics course to highly gifted 10th gradestudents. The course emphasizes problem-sohing andexploration, and requires flexibility and creativity fromthe instructor. Experience in research, directing studentresearch, and computers is recommended. In additionapplicants should be able to teach one or more of thefbilowing elective courses: electronics, astrophysics,modemn physics, and observational astronomy.The Academy is a 3-year residential school which

offers college-level courses to high school students highlygifted in mathematics and science. The Academy is 40miles west of Chicago. Applications can be obtainedfrom:

Illinois Mathematcs and Science Academy1500 West Sullivan Road

Aurora, IL 60506An Equal Opportunity Employer

TENURE-TRACK FACULTY POSITIONDEPARTMENT OF

METALLURGICAL ENGINEERINGAND MATERIALS SCIENCE

CARNEGIE MELLON UNIVERSITYThe Department has openings for faculty mcmbers at

the assistant, associate, or full professor lcvel, and isseeking prospective candidates. Desired areas of special-ization include polymeric materials, physical metalurgyand surface and thi film sciences. Applicants shouldhave a Ph.D., a demonstrated research potential orrecord in topics covered by the above areas, be interestedin developing a very strong research program, and beenthusiastic and qualified to teach.

Please send resume and a list of references to: Profes-sorA. W. Thompson, Head, Department ofMctallur-gical Engmeersng and Materials Science, CarneieMcllon University, Pittsburgh, PA 15213. Tele-phone: 412-268-2700. Equal OpportunitylAffirmutieAction Employer.

VETERINARY MICROBIOLOGISTA tenure-track position in veterinary microbiology. A

Ph.D. or D.V.M./Ph.D. required. Responsibilitics in-dude research in broad area of pathogenic mechanismsand immunobiology of bacterial diseases of animals;supervision of diagnostic microbiology lab and teachingan undergraduate and graduate course.

Experience in molecular biology, recombinant DNAtechnology and immunology is desirable. Rank andsalary commensurate with experience. Send curriculumvitae and three references to: Dr. Louis van der Heide,Search Committee, Departmcnt of Pathobiology,University of Connecticut, U-89, Room 103, 61

Eagleville Road, Storrs, CT 06268. (Search #8A309).

SYMPOSIUM

IN SITU EVALUATION OF BIOLOGICALHAZARDS OF ENVIRONMENTAL POLLU-TANTS, 5 to 7 December 1988; Hotel Europa, ChapelHill, North Carolina. The meeting will focus on theapplication of currently available bioassays for in situenvironmental assessment and on the evaluation of theutility of integrated chemical and biological data ob-tained under real world conditions for the assessment ofhuman health effects from exposure to a given environ-ment. Requests for registration materials should be madeto: Barbara M. Andon, Environmental Health Re-search and Tesing, Inc., P.O. Box 12199, ResearchTrianglc Park, NC 27709. Telephone: 919-541-7532.

WORKSHOP

THE ECONOMIC IMPACT OF AIDS27 SEPTEMBER 1988

Conference in Baltimore sponsored by the Johns Hop-kins University School of Public Health. Focus onmethodological issues in the design and implementationof study to estimate direct and indirect costs related toHV infection. Attendance limited to approximately 300persons. Details and application forms from: AIDSConference, 407 Hampton House, 624 North Broad-way, Baltimore, MD 21205.

FELLOWSHIPS

POSITDOCTORAL FELLOWSHIP available im-mediately to work on molecular aspects ofT lymphocyteactivation. Projects include examination of myc and frsoncogenc expression, generation of intracellular secondmessengers, and control of calcium ion flux in T cellsubsets of normal and aging mice. Send curriculum vitaeand names ofthree references to: Dr. Richard A. Miller,Boston University Mcdical Center, 80 East ConcordStreet, Boston,MA 02118.AnAffimativeAtion/Equa1Opportunity Employer

POSTDOCTORAL FELLOWSHIP, NIH. Re-search in: evolution and molecular genetics of genescoding for enzymes that metabolize drugs, carcinogensand occupationally hazardous substances; positive andnegative regulatory elements; characterization of gcnesencoding trans-actmng factors; developmental and tissue-specific gene expression. Clinical applications: predictingindividual rsk of certain malignancies and adverse drugreactions. Background in molecular biology or biochem-istry is required. Salary commensurate with experienceand qualifications. Send curriculum vitae and the namesof three references to: Dr. Daniel W. Nebert, Building

6, Room 416, National Institutes of Health, Bethes-da, MD 20892. Equal Opportunity Employer.

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ACQUISITION OPPORTUNITY FORRESEARCH ANIMAL BREEDER ANDLIFE SCIENCE RESEARCH FACILITY

One of largest specialty breeders in the world. AAALACaccredited. Three colonies of substantial size. Known lin-eages and medical histories. 1987 sales S3.2 million. 12.8%pretax income. High margins in research operations. Equityover $2.5 million. Strong growth opportunity. 70 acre sitewith substantial capacity for expansion. High volume ofintemational (Japanese) sales. Send qualifications to:

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