perspectives on nutrition for breast...
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Perspectives on Nutrition for Breast Cancer
Dr Andrea Braakhuis
Sweet Louise Advanced Cancer Forum
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Diet does appear to reduce mortality in those with breast cancer Mediterranean diet may have some advantagesER+ types appear to respond to dietA healthy diet improves non breast cancer mortality (often overlooked!)
Kim EH, Willett WC, Fung T, Rosner B, Holmes MD (2011) Diet quality indices and postmenopausal breast cancer survival. Nutr Cancer
63:381–388
Izano MA, Fung TT, Chiuve SS, Hu FB, Holmes MD (2013) Are diet quality scores after breast cancer diagnosis associated with improved
breast cancer survival? Nutr Cancer 65:820–826
Inoue-Choi M, Robien K, Lazovich D (2013) Adherence to the WCRF/AICR guidelines for cancer prevention is associated with lower mortality
among older female cancer survivors. Cancer Epidemiol Biomark Prev 22:792–802
George SM, Irwin ML, Smith AW et al (2011) Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and
prognosis after early-stage breast cancer. Cancer Causes Control 22:589–598
George SM, Ballard-Barbash R, Shikany JM et al (2014) Better postdiagnosis diet quality is associated with reduced risk of death among
postmenopausal women with invasive breast cancer in the women’s health initiative. Cancer Epidemiol Biomark Prev 23:575–583
Diet and post-diagnosis mortality
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Waist circumference
Weight
Findings
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LDL cholesterol
Findings
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DNA Damage
Findings
*
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Nutritional education and group support appears to benefit breast cancer survivors and of lesser importance is the type of diet that forms the basis of the education
Conclusion
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Mediterranean Diet
• High in fruits, vegetables, cereals, and legumes• Low in red meat• High in olive oil (unsaturated fat)• Beneficial protective effect due to high levels of unsaturated
fat and antioxidants (in particular, polyphenols)
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How to eat a Mediterranean Diet
• Eat Daily
– 3 servings of fruit
– 3+ servings of
vegetables
• Eat weekly
– 3 servings of fish (not fried)
– 3 servings of legumes
• Choose
– Olive oil and nuts most days
– Mostly white meat, chicken and fish
• Limit
– Cookies, pastries, pies and candy
– Red meat and
processed meat
– High fat dairy
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How to eat a Low Fat Diet
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Latest research….
What next?
Interview data
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Theme B: Surprise and concern associated with changes to weight and diet
Weight gain was unexpected and disappointing
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Theme C: Insufficient dietary information and support
Dietary information general or not provided
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Theme C: Insufficient dietary information and support
Need for dietetic services
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“During the post-diagnosis period, information
about diet and dietary changes during treatment
often lacked specificity or was not given. That
lacking specificity included booklets and
brochures from hospitals and clinics and verbal
advice from health professionals. Several
participants reported not receiving any dietary
information at all. “
Kwok, A., Palermo, C. & Boltong, A. Support Care Cancer (2015) 23: 1561.
doi:10.1007/s00520-014-2496-5
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Kanaya, N., Adams, L., Takasaki, A., & Chen, S. (2014). Whole blueberry powder inhibits metastasis
of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory
cytokines. Nutrition and cancer, 66(2), 242-248.
Noratto, G., Porter, W., Byrne, D., & Cisneros-Zevallos, L. (2014). Polyphenolics from peach (Prunus
persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in
vivo. The Journal of nutritional biochemistry, 25(7), 796-800.
Nutrition and metastatic cancer
Mak, K. K., Wu, A. T., Lee, W. H., Chang, T. C., Chiou, J. F., Wang, L. S., ... & Ho, C. T. (2013).
Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer
stem cells within tumor microenvironment and metastasis via modulating NF‐κB/microRNA 448
circuit. Molecular nutrition & food research, 57(7), 1123-1134.
FRUIT IS GOOD!
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Thank-you
http://dietitians.org.nz/find-a-dietitian/