pesticides-online and method validation database
TRANSCRIPT
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Pesticides-Online andMethod Validation Database
Two Database Modules to Access Pesticide-Related Data via the Internet
Dr. H. ZipperChemisches und Veterinäruntersuchungsamt StuttgartEU-CRL for Pesticide Residues using Single Residue M ethods
TestVersionOnline!
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2CRL forResidues of Pesticides SRM
CRL-Pesticides-Websitewww.???.eu
[= website for experts]
CRL-FVFruits & Vegetables
CRL-CFCereals & Feeding Stuff
CRL-FAOFood of Animal Origin
CRL-SRMSingle Residue Methods
CIRCA
Document Management
System
→ www.pesticides-online.com→ Method Validation Database
Two Database Modules to Access Pesticide-Related Da ta:
Member-Area
[restricted access]
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3CRL forResidues of Pesticides SRM
Targeted Sampling & Analysis
Important is not only
How You Analysebut also…
What You Analyse!
High-Tech-Instrumentation & Fast Sample Preparationare Important, but...
Set priorities based on information...
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4CRL forResidues of Pesticides SRM
… using SRM
Potential Spectrumof the MRM
Entire spectrumof pesticides
Relevant spectrum
Pome Fruit
Relevant spectrum
Berries
Laboratory spectrumusing the MRM
Targeted Analysis
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5CRL forResidues of Pesticides SRM
… using SRM
Potential Spectrumof the MRM
Entire spectrumof pesticides
Relevant spectrum
Pome Fruit
Relevant spectrum
Berries
Laboratory spectrumusing the MRM
Targeted Analysis
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6CRL forResidues of Pesticides SRM
DATA-POOL: Collection/Distribution of Information
Common Data-Pool
Lab 1
Lab 2
Lab 3
Lab 4 Lab 5
Lab 7
Lab 6
INTERNET
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7CRL forResidues of Pesticides SRM
PESTICIDES-ONLINE
- Information Exchange between Laboratories- Enable Targeted Pesticide-AnalysisAims:
Residue Findings
Pesticide-Usage
Data
Discussion-Forum
Pesticide-
Data-Sheets
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8CRL forResidues of Pesticides SRM
www.pesticides-online.com
Navigation barNavigation bar
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9CRL forResidues of Pesticides SRM
Registration to Pesticides-Online
� Online-Registration is necessary!
� After Registration only the Forum is can be used.Administrator will contact you by email and give you an access!
� The access is free of charge .� Different access rights to Pesticides-Online :
- Full access for official labs/organisations, labs/organisation thatsubmit data (e.g. residue findings)
- Limited access for labs/organisations that submit no data- No access for NGO, journalists, private individuals, …
Fill-in the requested information and
submit.
Fill-in the requested information and
submit.
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10CRL forResidues of Pesticides SRM
Pesticides-Online Users Around the World:
D 193
CH 29
IT 31
ES29
USA 30
UK 14
F 13
NL 12
BG5
JP19
SK6
SE 6
BE 10
BR7
EE 3
FI 3
IE 2
AT 7
DK 3
KR 3
RL1
MA 3
ZA1
PT4
IN 1IL
1
PL 9
CZ4 HU
3
SI 3
GR 8
RO 1
AU2
TR 13
LV 1
GH 2
CY 1
SD 1
CN 2
AR3
UY3CL
2
IS1
Currently 506 users from 53 countries
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11CRL forResidues of Pesticides SRM
Sorting optionsfor theresults
Sorting optionsfor theresults
Various filter options for a targeted query
Various filter options for a targeted query
View reference and contact-information by clicking hereView reference and contact-information by clicking here
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12CRL forResidues of Pesticides SRM
Residue Data
>1 000 000 Entries(> 75 000 pos.)
314 Different Commodities
116 Countries of Origin
678 Compounds Sought
512 Compounds Found
91 Info Sources (35 labs)
Pesticides-Online - Statistics
min4 5 6 7 8 9
0
10000
20000
30000
40000
50000
60000
70000
80000
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13CRL forResidues of Pesticides SRM
Results of Lab-Questionnaire 2006
� Website-section of lab-questionnaire:
What types of data would you like to see in our common CRL website?
Would you be willing to contribute data to such a database(= RESIDUE FINDINGS Database)?
61
1
38
0
10
20
30
40
50
60
70
Yes No Don`t know yet
%
(71 answersto this questions)
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14CRL forResidues of Pesticides SRM
Data Submission to Pesticides-Online
� For more convenience, we try to use the data-formats (residue findings) that our users are already utilizing in their lab and translate them into ours.
� Thus, please send us an exampleof your data so that we can look at it and see what we can do.
� If you don't have a LIMS in your lab, we can also offer you a tool basedon Microsoft Access to easily collect your pesticides residue data.
� Which information do we need at least?- Commodity (+ Processing)- Pesticide sought for + value(negatives also interesting!!!)
- Year of analysis- Country of origin- (Other: organic, MRL-violation)
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15CRL forResidues of Pesticides SRM
Sorting optionsfor the
query results
Sorting optionsfor the
query results
Various filter options for a targeted query
Various filter options for a targeted query
View reference and contact-information by clicking hereView reference and contact-information by clicking here
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16CRL forResidues of Pesticides SRM
Agricultural Usage Data
>16 000 Entries
194 Commodities
473 Pesticides
35 Countries/Regions
Pesticides-Online - Statistics
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17CRL forResidues of Pesticides SRM
Sorting optionsfor theresults
Sorting optionsfor theresults
Printing optionPrinting option
Click here to see the„Pesticide Data Sheet“
Physicochemical, Toxicological and Analytical Information for
795 Pesticides and Metabolites
Click here to see the„Pesticide Data Sheet“
Physicochemical, Toxicological and Analytical Information for
795 Pesticides and Metabolites
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18CRL forResidues of Pesticides SRM
Analytical Data Analytical Data
Physicochemical and Toxicological Data
Physicochemical and Toxicological Data
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19CRL forResidues of Pesticides SRM
Physicochemical data:- pKa- Water solubility- …Toxicological data:- ARfD- ADI
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20CRL forResidues of Pesticides SRM
Typical recoverieswith variousmultiresidue methods GC-Behavior
LC-Behavior
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21CRL forResidues of Pesticides SRM
Unfortunately the Forum is not much used up to now.
But ...
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22CRL forResidues of Pesticides SRM
Results of Lab-Questionnaire 2006Would you like a discussion forumto be established?
92
8
0
10
20
30
40
50
60
70
80
90
100
Yes No
%
(74 answersto this questions)
Would you be willing touse such a forum?
91,4
7,11,4
0,0
10,0
20,0
30,0
40,0
50,0
60,0
70,0
80,0
90,0
100,0
Yes No No, due to lack oftime, not lack of
interest
%
(70 answersto this questions)
Would you like the forum to be accessible also to colleagues outsite the CRL/NRL-Network (e.g. colleagues from countries outside the EU, from private labs...)?
72
23
1 3
0
10
20
30
40
50
60
70
80
Yes No Analytical labs Don`t know yet
%
(69 answersto this questions)
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23CRL forResidues of Pesticides SRM
Method Validation Database
⇒ Enables the systematic collection andcustomized retrieval of data produced during method validation in different laboratories.
→ Database for storage of data generated within the aim of method validation experiments in various laboratories.
TestVersionOnline!
New project started this year:
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24CRL forResidues of Pesticides SRM
Registration to Method Validation Database
� Online-Registration will be necessary!
Fill-in the requested information and
submit.
Fill-in the requested information and
submit.
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25CRL forResidues of Pesticides SRM
Query Section: Various filter options for a targeted query
Filter options for commodityFilter options
for commodity
Filter options for extraction method,
ISTD, Cleanup, …
Filter options for extraction method,
ISTD, Cleanup, …
Filter options for compoundFilter options for compound
Filter options for lab name, …
Filter options for lab name, …
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26CRL forResidues of Pesticides SRM
1. Result list of individual recovery values
All important experimental parameters are shown!
All important experimental parameters are shown!
Aggregation mode 1Aggregation mode 1 Aggregation mode 2Aggregation mode 2
N° of hits:N° of hits:
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27CRL forResidues of Pesticides SRM
2. List with aggregated recovery data
Important experimental parameters are shown!Important experimental parameters are shown!
Aggegation line for all commodites at spiking level 0,01 mg/kg
Aggegation line for 2,4-D in Cucumber at Spiking level 0,01 mg/kg
Aggegation line for 2,4-D in Raisin at Spiking level 0,01 mg/kg
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28CRL forResidues of Pesticides SRM
Method Validation Database - Statistics
� currently only data for QuEChERS-Method,but Method Validation Database is flexible to receive data from any other method !
� Recovery data for QuEChERS-Method:- 478 compounds- 44 commodities (apple, raisin, lemon, …)- 17 labs data submitted
� Recovery data of S19- and ChemElute will be submitted soon from different labs.
You’re welcome to submit validation data from your lab!
But how to submit?
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29CRL forResidues of Pesticides SRM
Data Submission to Method Validation Database
� We offer a Data Submission-Format(→ Excel-file)If you are interested, please contact us!
� If you have huge amounts of recovery data, we will try to transform your data into our data-format.
internet
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30CRL forResidues of Pesticides SRM
...our Pesticide Residue Team...
Thank you very much for your Attention !