pet – positron emission tomography
DESCRIPTION
PET – POSITRON EMISSION TOMOGRAPHY. PET: POSITRON EMISSION TOMOGRAPHY. Most used PET radiotracers. Unstable nucleus. positron antiparticle of the electron (same charge, opposite semn). electron. positronium. 2 gamma photons, 511 keV. Coincidence detection (interval 10 -9 sec.). - PowerPoint PPT PresentationTRANSCRIPT
PET –PET –POSITRON EMISSION POSITRON EMISSION
TOMOGRAPHYTOMOGRAPHY
PET: PET: POSITRON POSITRON EMISSION EMISSION
TOMOGRAPHYTOMOGRAPHY
Izot.
Radiotracer Mecanism
18F 18F FDG (90%) Glucidic Metabolism18F-Fluoro-Dopa dopaminergic Sintesys18F-Fluoro-misonidazole
Tumoral Hipoxia
18F-Uracil (FU) Chimioterapy evaluation (5FU)18F FLT FluoroTimidin
Cellular Proliferation
15O H²O15 Perfusion11C 11C-Acetat Oxidativ Metabolism (miocardic +
tumoral)11C-Palmitat Miocardic Metabolism (acizi graşi)11C-Tirozin Tumoral Metabolism11C-Timidin Cellular Proliferation11C-Metionin Tumoral Metabolism11C-Colin Tumoral Metabolism11C-Acid-Amino-IsoButiric
Tumoral Metabolism
11C-Acid-Amino-Ciclopentan-Carboxilic (ACPC)
Tumoral Metabolism
13N 13N-NH3 (amoniac) Miocardial Perfusion13N-Glutamat Tumoral Metabolism
Most used PET radiotracers
PETprinciple
Unstable nucleus
positronantiparticle of the electron (same charge, opposite semn)
electron
positronium
2 gamma photons, 511 keV
Coincidence detection(interval 10-9 sec.)
detector: Bi germanat crystal(BGO)Photomultipliers around
Anihilation process
Desintegration throughpositron emission
Anihilationelectron/positron
Anihilationphoton
Anihilationphoton
Device
The germinating idea of PET: The germinating idea of PET: Nobel Prize Medicine Laureat, Dr. Otto Warburg:Nobel Prize Medicine Laureat, Dr. Otto Warburg: <The prime cause of cancer is the replacement of the <The prime cause of cancer is the replacement of the
respiration of oxygen by normal body cells by a respiration of oxygen by normal body cells by a fermentation of sugar> fermentation of sugar>
PET: analogs metabolicGlucidic Metabolism
Glicolisys in malignant cell
GLUT8
GLUT6
GLUT transporters
1818FFDG FFDG ((1818F-2fluoro-F-2fluoro-
2deoxi-Dglucose)2deoxi-Dglucose)
PET IndicatiPET Indicationon
MiocardiMiocardial al Scintigra Scintigraphyphy TumoralTumoral Scintigra Scintigraphyphy : : pulmonar neoplasmpulmonar neoplasm mamarmamaryy neoplasm neoplasm cerebral neoplasmcerebral neoplasm ovarianovarian gastrointestinal neoplasgastrointestinal neoplasiaia limlimphphomomaa Head-neck Head-neck tumortumorss endocrin tumorendocrin tumorss : t : thyhyroidian, carcinoid, roidian, carcinoid,
phpheocromocitomeocromocitomaa
Normal 18FFDG PET imageNormal 18FFDG PET image
Normal PET and PET-CT images
Pathologic Pathologic 1818F FDG F FDG PET images in cancerPET images in cancer
Lung cancerLung cancer
Lung cancer Lung cancer with metastaseswith metastases
Hodgkin Hodgkin lymphoma with lymphoma with metastasesmetastases
MelanomaMelanoma
PET-CT images
CTPET PET - CT
Imagini PET (18FFDG), CT şi PET-CT normale (secţiuni coronale)
PET + CT = PET-CT