PhD Position in Vascular and Tumor Biology

University of Lausanne, Switzerland

Vascular and Tumor Biology Laboratory studies vascular specialization and the role of vessels in the regulation of tissue- and cancer-specific stem cells. We use normal intestine, colon cancer, adipose tissue and lymph node as model systems and we employ genetic animal models, coupled with ex-vivo analyses of stromal and cancer cells, tumor organoids and large-scale characterization of human tumors. We seek to attract talented PhD students interested in understanding key biological process underlying formation and function of blood and lymphatic vessels. The selected candidate will work on a project investigating the communication of endothelial, perivascular and stem cells during adipogenesis and tumor expansion. PhD student profile • M.Sc. in biology, biochemistry or closely related discipline • Strong background in cell and molecular biology • Interest in work with genetically modified animal models • Curious, driven by the need to understand, and goal-oriented • Good team spirit We offer • A 4-year PhD position in outstanding scientific environment of the Department of

Oncology at UNIL and Ludwig Institute for Cancer Research • Attractive salary according to Swiss National Foundation scale • International, multilingual and multicultural environment Starting date • As soon as possible, to be discussed Applicants should send a CV, including the names and addresses of at least two referees, to Dr. Tatiana Petrova Tatiana.petrova@unil.ch Recent publications • Ragusa. S. et al., Antiangiogenic immunotherapy suppresses desmoplastic and

chemoresistant intestinal tumors in mice. J Clin Invest, 2020 • De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour

angiogenesis. Nat Rev Cancer. 2017. • Hendrikx, S. et al. Endothelial calcineurin signaling restrains metastatic outgrowth by

regulating Bmp2. Cell Reports. 2019 • Bovay, E. et al. Multiples roles of lymphatic vessels in development of peripheral lymph

nodes. J Exp Med. 2018. Werner Risau prize 2019 • Sabine A, et al. Foxc2 and fluid shear stress stabilize postnatal lymphatic vasculature. J

Clin Invest. 2015 Ranked “Exceptional” by F1000 • Bernier-Latmani J et al. DLL4 promotes continuous adult intestinal lacteal regeneration

and dietary fat transport. J Clin Invest. doi:10.1172/JCI82045. 2015. Pfizer Biomedical Research Award 2017

Laboratory Vascular and tumor biology

Department of oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne http://www.unil.ch/deo/home/menuinst/research-activities.html