photonic and optic technologies with potential for health applications. prof ben eggleton, school...

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IPOS - Institute of Photonics and Optical Science Director, Institute of Photonics and Optical Science (IPOS) Director, CUDOS ARC Centre of Excellence School of Physics http://sydney.edu.au/ipos/ Prof. Ben Eggleton, ARC Laureate Fellow

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Page 1: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

IPOS - Institute of Photonics and Optical Science

Director, Institute of Photonics and Optical Science (IPOS)

Director, CUDOS ARC Centre of ExcellenceSchool of Physics

http://sydney.edu.au/ipos/

Prof. Ben Eggleton, ARC Laureate Fellow

Page 2: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Photonics: Critical enabling science

› Photonics is the science and technology of generating, controlling and detecting photons (began with the invention of the laser 53 years ago)

Page 3: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Introduction to IPOS

› ~100 Members from the

- School of Physics, incl.

- CUDOS – Sydney, Astrophotonics, Quantum

- Electrical Engineering

- Fibre-optics and photonics laboratory

- School of Chemistry

- Interdisciplinary Photonics Laboratories

- Molecular Spectroscopy & Photonics

- School of Mathematics and Statistics

› 55 Researchers

› 35 Research Students

IPOS Institute of Photonics and Optical Science

F P L Fibre-optics & Photonics

Laboratory

“To provide Australia with the innovation, scientists and engineers to maintain and enhance a position of world-

leadership in photonics, in academia and industry.”

Page 4: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Research

› Diverse research areas

IPOS Institute of Photonics and Optical Science

Ultrafast photonicsQuantum photonicsCommunicationsAstrophotonicsOptical fibre technologyNonlinear opticsHigh power & mid-IR lasersIntegrated and nanophotonicsMicrofluidicsBiomedical photonicsRenewable energyDefence photonicsMolecular spectroscopyOptical sensingMicrowave and Terahertz

Page 5: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Fibre Biomedical Photonics

› Microstructured Polymer Optical Fibre- Holes provide guiding, and sensitivity

› Unique capability at University of Sydney

› Inexpensive to access through ANFF

› PMMA (Perspex)- Extremely low cost – disposable sensors

- Biocompatible / non-hazardous

› “Lab in fibre” - Ultrasensitive molecular detection

- Picolitre volumes

- Long interaction lengths

› But also - On Body (non-invasive), and

- In Body (invasive)

sensing / interfacing opportunities…

Page 6: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Fibre Biomedical Devices› Non-invasive Sensing

- Fibre - sensitive to temperature, bending, pressure…

- Example: Heart rate monitor, integrated with PPE ->

- Potential: Fibre combined with bandage, could provide long term, continuous, inexpensive pressure monitoring, including remotely.

- Also monitor heart-rate, blood pressure, or physical exertion.

› Invasive Interfacing

- Neural interface – channels for:

- Electrical: detection and stimulation

- Chemical: drug delivery

- Optical: optogenetic detection and stimulation

- Developed for neuroscience research

J. Witt et al, POF 2011 Bilbao (Spain) Conference Proceedings – SENSORS II

Page 7: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Microfluidic channel:Fluid constrained on the micron scale

Optical channel:Light constrained on the micron scale

Optofluidics: Photonics + Microfluidics

Source: http://www.optofluidicscorp.com/

Microfluidics + microphotonics Flexible optical systems at the microscopic scale

• C. Monat, P. Domachuk, B. J. Eggleton, “Optlofludics”, Nature Photonics 2012• V. Oncescu, et al, “Smartphone based health accessory for colorimetric detection of biomarkers in sweat

and saliva,” Lab on a Chip 13, 3232 (2013)• A. Casas-Bedoya, et al, “Chip scale humidity sensing based on a microfluidic infiltrated photonic

crystal,” Appl. Phys. Lett. 103, 181109 (2013);• H. Schmidt et al “Photonic integration of nonsolid media using optofluidics. Nat. Phot, 5, 598 (2011).

Erickson/Cornell

Page 8: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

• S. Kim, et al “Silk inverse opals,” Nat. Phot. 6, (2012).• P. Domachuk, et al. “Bioactive ‘self-sensing’ optical systems.,” Appl. Phys. Lett. 95, 253702 (2009).• F. G. Omenetto, “Bioactive silk protein biomaterial systems for optical devices,” Biomacromolecules 9, 1214 (2008).• S.T. Parker, P. Domachuk, et al. “Biocompatible silk printed optical waveguides,” Adv. Mater. 21, 2411–2415 (2009).• H Perry, F.G, Gopinath, ”Nano- and micropatterning of optically transparent, mechanically robust, biocompatible silk

fibroin films,”. Adv. Mater. 20, 3070–3072 (2008).

BiocompatibilityBiologically favourable carrier that allows biodopants to maintain their function while held within its crystalline matrix with remarkable robustness

Silk photonics

Page 9: Photonic and optic technologies with potential for health applications. Prof  Ben Eggleton, School of Physics

Australian Institute of

Nanoscience (AIN)

-10,500 m2 building-600 m2 clean room (nanolithography)-Photonics a key driver (1 floor of labs)-Interdisciplinary focus

Photonics at the University of Sydney