physiology of autonomic nervous system
DESCRIPTION
ANS divisions, distribution, receptors, functions, and autonomic drugsTRANSCRIPT
Autonomic Nervous System
Nermeen BastawyPhysiology Department
Faculty of MedicineCairo University
2
Central nervous system(brain & spinal cord)
Central nervous system(brain & spinal cord)
Peripheral nervous systemPeripheral nervous system
Somatic or Voluntary Autonomic or Involuntary
SympatheticSympathetic ParasympatheticParasympathetic
Cardiac& smooth ms, glands skeletal ms
Brain sp.cd
Origin
s
1 8
Somatic # ANS
motor
SOMATIC # AUTONOMIC
AUTONOMIC NERVESAUTONOMIC NERVES
Smooth & cardiac ms
• Ganglia
• From LHCs
• NT: Ach, catecholamine
• Pre G myelinated B
• Post G unmyelinated C
SOMATIC NERVESSOMATIC NERVES
• sk. ms.
• NO GANGLIANO GANGLIA.
• AHCs
• NT : ACh
• Myelinated A fibers.
13/07/2010 5
Types of ganglia
Cranial nerves
Spinal cord Terminal
Collatral
Para vertebral
Adrenal gland
ANS
• Sympathetic NS stress : -“Fight or flight”
-“E” division:exercise,emergency.
• Parasympathetic rest:-Maintain normal functions
-“D” division: digestion,
defecation, and diuresis.
Horner syndrome
NA
A
Symp. Thoracolumber
T1 L3Craniosacral1973, S2,3,4
Ganglia away from organs
Ganglia near to organs
Long postgang. Short postgang.
NA, Ach Ach13/07/2010 13
Parasym.
ANS H & N Parasymp Symp.
Eye (Iris) Myosis. Mydriasis.
Eye (Ciliary ms) Contraction . No innervation.
Eye(Muller ms) No innervation Contraction.
Salivary Gland Watery sec. Mucous sec.
Sweat Glands No innervation ++sweating
Hair follicles No innervation Piloerection
Target Organ
Parasymp. Symp
Heart - - - HR.
VC coronary
++ HR & force VD coronary
Lungs Bronchoconst. Bronchodil.
GIT ++ peristalsis, secretion & bile.
-- peristalsis, secretion.
UB& rectum Urination & defecation
Retension.
Genetalia Erection Ejaculation.
Medulla oblongata
III
Ciliary ganglion
Ciliary muscle, circular muscles of irisVII
Lacrimal gland
Sphenopalatine ganglion
Submaxillary and sublingual gland
Submaxillary ganglion
IX
Parotid gland
Otic ganglion
X
Heart,lung, intestine
Nervi irrigantis Kidney, bladder, colon and genitals
Pelvic ganglion
Cervical
Lumber
Sacral
Thoracic
18
Cervical
T1T2T3T4T5T6T7T8T9
T10T11T12L1L2L3
Thorax
H & NCG
CG ,SMGGIT , liver , spleen &
adrenal gland
IMGGenitals
Heart,
19
•Ach :Fiberscholinergic F
Receptorscholinergic R
•NA :Fibersadrenergic F
Receptorsadrenergic R
Sweet G Sweet G Bl.VBl.V
Pre GPre G
Post GPost G
Ch RCh R
Ch RCh RXXXXXX
XXXXXXXXXXXXXXXXXX
Ch RCh R
Ad RAd R
ANS
SYMPATHETIC PARASYMPATHETIC
SOMATIC NERVOUS SYSTEM
ACh
adrenal medula
NA & A in blood
ACh
NA
ACh
ACh
Bl.V sweat glands
MANY ORGANS
ACh
AChACh
Nm skeletal muscles
NN NN NN NN
NN
22
MANY ORGANS
AChACh NANASites Sites Nerve Knobs Nerve knobs
Adrenal G
Source Source Choline+Acetyle-COA
Dopamine
Storage Storage Clear vesicle Dark vesicle
Release Release AP Ca++ Exocytosis
Remove Remove Ach esterase Reuptake
MAO/COMT
Decarboxylase
PNMT PNMT adrenaladrenal glandgland
in liver
Cholinergic RCholinergic R
Central = Nicotinic R
Periphral = Muscarinic R
a
B
B
a
Autonomic drugs
++++ - - - - -Ganglionic +++ Ganglionic ---
Sympatho-mimetic
Sympatholytic
Parasympatho-mimetic
Parasympatho-lytic
Sympathetic drugs
Sympathomimetic ++++
Sympatholytic - - - - -
Ganglia NSD
Antich.esterase
NLD
TEA
Alpha R
Beta R
A, NA
A, ISP
Phentolamine
Propranolol
NT Ephedrine
Amphetamine
Tyramine
Guanethidine
Reserpine
Methyldopa
Parasympathetic drugs
PS-mimetic +++ PS-lytic - - -
Ganglia NSD
Antich.esterase
NLD
TEA
Muscarinic R
Antich.esteraseMuscarinePilocarpine Metacholine
Atropine
Homatropine