physiology of exercise performance and limitations ward ebpom l1.pdf · icb isocapnic buffering...
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PHYSIOLOGY OF EXERCISE PERFORMANCE
AND LIMITATIONS
Susan A. Ward DPhil
Human Bio-Energetics Research Centre
Crickhowell, Powys, United Kingdom
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High forcegeneration
High glycolyticcapacity
High oxidativecapacity
SKELETAL MUSCLE
bfeModified from Jones DA & Round JM. Skeletal Muscle in Health and Disease: A Textbook of Muscle
Physiology. Manchester Univ Press, 1990.
“2x”
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Constant Work-Rate Exercise
Incremental Exercise
Modified from Maughan R, Gleeson M & Greenhaff PL.Biochemistry of Exercise and Training, Oxford University Press, 1977.
muscular force or work rate
High force-generation;high glycolytic
capacity
Low force-generation; high oxidative
capacity
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Decrd. proportion of Type 1 & incrd. proportion of
Type 2x fibres (with loss of oxidative capacity):
COPD (Whittom et al. Med Sci Sports Exerc 30:1467-
1474, 1998)PAH (Mainguy et al. Thorax
65:113-117, 2010)
IIx
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COPD: ↓ (Gosker et al. EurRespir J 30: 73-79, 2007)
COPD : ↓ (Whittom et al. Med Sci Sports Exerc30:1467-1474, 1998)
(From Hoppeler et al., 1973)
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Oxygen Uptake (L/Min)
Modified from Rowell LB. Human Cardiovascular Control
Oxford University Press, New York, USA, 1993.
CARDIOVASCULAR SYSTEM
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Q = 5⋅VO2 + 5••
“Rules of thumb”:
SV = 5⋅∆VO2 /∆HR
Whipp BJ, Higgenbottam MB, Cobb FC. Estimating exercise
stroke volume from the asymptotic oxygen pulse in
humans. J Appl Physiol81:2674-2679, 1996.
•
HR Reserve(HRmaxpred – HR peak)
NL ~ 0
Premature cessation of test:(e.g. Resp Dis)
(HRmaxpred > HR peak)HRR > 0
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●
●
●●●●
●●●●●
00
500
1
3
2
4
5
VO
2(L
/min
)
5 10 15 20 25 30
Q (L/min)
●
●
●
●
●
VO2 = Q(CaO2 - CvO2)• •
•
•
VO2/Q = (CaO2 - CvO2)• •
↑
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Fick Equation:
linear
-
-
Whipp BJ. Unpublished Susan A. Ward
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●
●
●●●●
●●
●●●
0
0
500
21 3 4 5
VO2 (L/Min )
C(a
-v)O
2(m
L/dL
)
5
10
15
20
25
6
●
●
●
●
●
●
C(a-v)O2 (mL/dL)
= 20VO2/(1+VO2)•
•
-
-
•
“Rule of thumb”:
hyperbolic
bfeWhipp BJ. Unpublished
Susan A. Ward
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VO2 = Q(CaO2 - CvO2)• •
Fick Equation
“Oxygen Pulse”
VO2/HR = SV(CaO2 - CvO2)
VO2 = HR.SV(CaO2 - CvO2)
Yandell Henderson & Alexander Prince,The Physiological Laboratory of the Yale Medical Sc hool THE OXYGEN PULSE AND THE SYSTOLIC DISCHARGE
“... the oxygen pulse which more than any other fac tor determines the total energy which a man can command for the most strenuous mome nts of life. Its maximum value
depends upon the haemoglobin index and the tidal vo lume of the heart.”(Am J Physiol 35:106-116, 1914)
•
•
bfeWhipp BJ. Unpublished
Susan A. Ward
-
-
-
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linear
hyperbolic
VO2/HR = O2-P = SV(CaO2 - CvO2)•
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-
Modified from Whipp BJ. Clinics in Chest Med. 15:17 3-192, 1994.
Whipp BJ. Unpublished. Susan A. Ward
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Substrate Free Energy
ATP Energy Yield
Work of Muscular Contraction
Work of Task Performance
(Phosporylative Coupling)
(Contraction Coupling)
(Skill)
“Work Efficiency”
ηpc ≈ 50%
ηcc ≈ 50%cycle
ergometry25-30%
bfeWhipp BJ & Ward SA. Unpublished
Susan A. Ward
ENERGETICS
1/ηw = 1/ηpc + 1/ηcc
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100 watts ≈ 1L/min
O2 Deficit:creatine phosphatepreviously-stored O2anaerobic glycolysis
∆ VO2
.
Response “Gain”: ∆VO2/∆WR ≈ 10 ml/min/watt.
bfeModified from Whipp BJ, Mahler M. In: Pulmonary Gas Exchange, Vol. II.
Ed.: West JB. New York: Academic Press, pp 33-96, 1 980.
exponential[time constant ( τ) = time to
reach 63% of steady-state response]
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O2 DEFICIT
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Modified from Nery LE, Wasserman K, Andrews JD, Hunt sman DJ, Hansen JE, Whipp BJ. Ventilatory and gas exchange kinetics during exerci se in chronic obstructive pulmonary disease.
J Appl Physiol 53:594-1602, 1982.
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(modified from Fukuoka et al. 2002)
1000
Figure 1
-4 -2 0 2 4 6200
400
600
800
1000
VO
2 (m
l · m
in -
1 )
τ = 96.8 s
τ = 71.0 s
(modified from Puente-Maestu et al. 2002)
-4 -2 0 2 4 6200
Time (min)
Healthy Elderly
COPD
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bfeModified from Whipp BJ, Mahler M. In: Pulmonary Gas Exchange, Vol. II.
Ed.: West JB. New York: Academic Press, pp 33-96, 1 980.
Modified from Wasserman K, Van Kessel AL & Burton GC. J Appl Physiol 22:71-85, 1967.
MODERATE INTENSITY
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bfeModified from Whipp BJ, Mahler M. In: Pulmonary Gas Exchange, Vol. II.
Ed.: West JB. New York: Academic Press, pp 33-96, 1 980.
Modified from Wasserman K, Van Kessel AL & Burton GC. J Appl Physiol 22:71-85, 1967.
> Lactate Threshold
HEAVY INTENSITY
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●
●
●
●
bfeModified from Whipp BJ, Mahler M. In: Pulmonary Gas Exchange, Vol. II.
Ed.: West JB. New York: Academic Press, pp 33-96, 1 980.
Modified from Wasserman K, Van Kessel AL & Burton GC. J Appl Physiol 22:71-85, 1967.
Maximum VO 2
.VERY-HEAVY INTENSITY
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THE RAPID RAMP/INCREMENTAL EXERCISE TEST
Whipp BJ. Unpublished Susan A. Ward
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●
●
●
●
●
●
●
●
x
x
x
x
x
x
“0” 1 2 3 4 5 6 7Time (min)
“0”
25
50
75
100
125
150
175
Wor
k R
ate
(Wat
ts)
“R”
2.25
2.0
1.75
1.25
1.5
1.0
0.5
0.75
VO
2 (L
/min
)
● ● ● ● X
bfe
Whipp BJ. Unpublished Susan A. Ward
.
Oxygen Uptake Response Profiles
t1/2 = 1 min
Half-time (t 1/2) = time to reach 50% of steady-state response
[τ = 1.44 t1/2]
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-WRGain(ss) = ∆VO2 / ∆WR = Gain(ramp).
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onset ofmetabolic (lactic) acidosis
VO2peak.
τ
Whipp BJ. Unpublished Susan A. Ward
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* * **
* *
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Whipp BJ. Unpublished Susan A. Ward
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FACO2 = VCO2 (STPD) or P CO2 = 863 x VCO2 (STPD)VA (STPD) VA (BTPS)
but as VA = VE (1 - VD/VT)
PaCO2 = 863(VE/VCO2) x (1-VD/VT)
PaCO2 is therefore determined by two composite variables:(a) ventilatory equivalent for CO 2(b) physiological dead space fraction of the breath
..
..
..
. .
Fick Principle: VCO 2 = VA x FACO2
CONTROL EFFICIENCY
A
. .
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VENTILATORY REQUIREMENTS
Whipp BJ. Unpublished Susan A. Ward
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linear hyperbolic
bfe Modified from Whipp BJ. Clinics in Chest Med. 15:173-192, 1994.
*
Whipp BJ & Ward SA. Unpublished. Susan A. Ward
Ventilatory Control
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●
●
●●●●
●●●●●
00
100
200
300
400
500
21 3 4 5VT (L)
VD
(ml)
VD/VT
0.2
0.1
0.13
Gas Exchange (In)efficiency
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Whipp BJ. & Ward S.A. Unpublished Susan A. Ward
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θL
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θL lactate threshold
RCP respiratory compensation point
ICB isocapnic buffering
Modified from Wasserman et al. “PETI”, 2005, p 246
Why doesn’t the respiratory compensation for the metabolic acidosis of exercise occur at the lactate threshold – i.e. when arterial pH first starts to fa ll?
The Respiratory Compensation Point
ICB
RCP
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(≈ 40 x FEV1)
MVV = Max voluntary ventilationBR = Breathing reserve
= MVV - VEpeak
COPD
Modified from Whipp BJ, Pardy R. In: Hbk Physiol, Resp (Pulmonary Mechanics). Eds: Macklem P, Mead J. Washington DC: Amer Physiol So c, pp 605-629, 1986.
Ventilatory Limitation
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↑VD/VT↓PaCO2
.
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The contemplation of those things which are normal is physiology,
and it is the first thing to be learned by medical men.
For that which is normal is right
and serves as a criterion for both itself and the a bnormal.
(William Harvey)
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