pierre d. mourad, phd research associate professor of neurosurgery, and of pediatric dentistry...
TRANSCRIPT
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Pierre D. Mourad, PhD
• Research Associate Professor of
Neurosurgery, and of Pediatric
Dentistry (adjunct)
• Principle Physicist at the Applied
Physics Laboratory
• PhD in Applied
Mathematics/Atmospheric Sciences
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how Jack and I got started
• I wanted some of his money for research on brain monitoring.
• He suggested we form a dental company instead
• the value of serendipity! connections matter! - then act fast!
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old news: ‘ordinary’ power brushes
• power brushes move their bristles several hundred times per
second and clean primarily at the point of bristle contact, in a
manner vastly more efficient than manual brushes.
I felt we could do better
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what is special about the Ultreo
note the transducer &waveguide
note the ultrasound coming out
we figured out how to put that ultrasound to good use
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bubbles can clean
• bubbles in the presence of ultrasound get bigger and
smaller and bigger and smaller...
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bubbles can clean
• bubbles near an surface - such as teeth - can get bigger
and smaller in a highly asymmetric way, applying
mechanical and therefore cleansing stress to that surface
QuickTime™ and aCinepak decompressor
are needed to see this picture.
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bubbles can clean
• a bubble, in ultrasound, can
generate significant mechanical
stress on things that come near it,
whether or not that bubble
collapses violently.
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what is special about the Ultreo
• the Ultreo’s bristles scrub on time scales similar to that of
other power toothbrushes - hundreds of times a second.
Thanks to the ultrasound-activated bubbles, the Ultreo also scrubs teeth several hundred thousand times a second, wherever the ultrasound and foamy dental slurry intersect, including where the bristles don’t reach.
ultrasound emittedfrom brush headinto dental foam
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some of our earliest prototypes
a value of working within UW at the early stages:you don’t have to create an entire laboratoryand gather the experts - they already exist on campus!
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we’ve come a long way
• a testimony to the initial vision, the initially applied resources and alacrity of
SAP/APL/Neurosurgery/Pediatric Dentistry/Periodontology/Public Health,
and the subsequent and considerable effort and expertise utilized at what
is now Ultreo, along with continuing efforts of UW among other institutions.
vs
‘first brushing story’
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ultrasound from a stationary brush rapidly removes a ‘line’ of plaque.
• Artificial teeth with plaque dyed pink before (left) and after (right) application of
ultrasound from beyond the reach of the bristles. Discrete plaque colonies along a band
stretching from lower left to upper right were removed by the ultrasound, in a shape
corresponding to the shape of ultrasound emitted from the face of the stationary brush
head. no bristle contact!
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plaque removal via combined sonic & ultrasound processes
• Artificial teeth with plaque dyed pink before (left) and after (right) treatment with a
sonically vibrating brush head that emitted ultrasound in the presence of sonically
produced bubbles, from 2-3 mm beyond the reach of the bristles. Discrete plaque
colonies were reduced or removed across the entire tooth surface after only 5
seconds of application of the prototype.no bristle contact!
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Research Models & CapabilitiesLaboratory Clinical & Subjective
once one has raised enough money, one can match thebusiness & business-science needs with unique, non-UW resources
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Dental Plaque Biofilm Removal
Oral-B Triumph
SonicareUltreo
•Hydroxyapatite disks (5mm dia., white) coated with Streptococcus mutans biofilm stained with disclosing solution (pink)
•Disk placed 2-4 mm from active cleaning surface (bristles / ultrasound waveguide) in dental slurry and exposed for 5 sec.
•Removal of biofilm after exposure compared to non-treatment control disks
Exposure without bristle contact:
Research Conducted by:
Frank Roberts, DDS, PhD
Pierre D. Mourad, PhD
University of Washington, Seattle WA
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Ultrasound activated bubbles clean into areas bristles do not reach
Ultreo
Sonicare
Oral-B1 mm
Ultreo
1 mm
Dental Plaque Biofilm Removal
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Longer Lasting Clean (in-vivo)
2 hrs after brushing it appears that Ultreo resulted in less plaque formation than brushing with sonic alone.
(2 treatments, n=5)Research Conducted by:
Baltuck C et al.
Ultreo Inc, Redmond, WA
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Hypothesis
Typical Brushing Ultreo
Ultreo’s ultrasound – activated bubbles extend
cleaning deeper than typical brushing
Ultreo results in a more thorough clean
Use of Ultreo leaves a long-lasting feeling of clean
bristle
plaque
tooth
bristle
ultrasound activated bubbles
plaque
tooth
Immediately after brushing
Several hours later
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lessonsfrom the field.
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Evolution of my relationship to Ultreo
2004-2006
Optimize Parameters: what are the
optimal technology conditions?
2006-2007
External Testing: independent
confirmation of safety &
effectiveness
Internal Testing:
what are the primary benefits?
2005-2006
Concept Testing:
does the concept deliver a benefit?
2003-2004
University of Washington
WTC Grants
Univ. of Wash.
& Ultreo
NIH SBIR Phase I Grant
Ultreo, Inc.
NIH SBIR Phase II
Grant
Ultreo, Inc. & Universities
NIH SBIR Phase II
Grant
Pierre as critical player -> Pierre as an important pet.
time of appropriaterapid growth
time of inappropriatelyrapid growth
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how is ultreo doing now?
first year, generated revenue at an annual rate of $10M!
but, it cost more than that to sell the brushes!! oh no!
strong CEO, with complicity of a weak Board, led the company
to market too fast, too optimistically. (there are lessons here!)
Board fired the CEO in Winter of 2008
Board - now alone - did additional damage to the company
(alienating the dental professionals - the key to the long-term
growth of any dental company).
VCs took over the company (cramming down extant investors)
VCs reconstituted the company, for possible sale of
technology or re-invigoration of the company - who knows.
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cautionary tale
• you have to get everything right to succeed in business, especially a start up, where there is no room for failure.
• your biggest asset, your weakest link, is people, sometimes even the same people.
• balance of power is critical to success (technical vs business; CEO vs Board)
• enormous work at first -> your baby grows up and leaves the home, while still needing to grow up more: learn to let go!
thank you.