placenta – part 1 – big 4 - department of pathology · placenta – part 1 – big 4 ... (look...
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From DB Singer
Maternal-Fetal-Placental Unit
PLACENTA – Part 1 – BIG 4 ASPEN 2014
Michael K Fritsch MD, PhD Northwestern University and Ann and Robert H. Lurie Children’s Hospital of Chicago
August 7, 2014
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Extra powerpoint posted covering Gross Placental Pathology Acknowledge: Dr. Linda Ernst (Head of NMH Perinatal Pathology). EXTENSIVE USE OF TEMPLATES. General References: 1. Atlas of Nontumor Pathology – Placental Pathology.
Kraus FT et al. eds. American Registry of Pathology, Washington DC, 2004. 2. Manual of Pathology of the Human Placenta, 2nd ed. Baergen RN.
Springer, New York, 2011. 3. Surgical Pathology Clinics: Placental Pathology. Baergen RN & Goldblum
JR eds. Elsevier, Philadelphia, 2013. 4. Pathology of the Placenta – Major Problems in Pathology, 3rd ed.
Fox H and Sebire NJ. Saunders-Elsevier, China, 2007. 5. Pathology of the Human Placenta, 5th ed. Benirschke K, Kaufmann P,
Baergen RN eds. Springer, New York, 2006.
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GOALS Review placental development. Review pathologic criteria and clinical implications of amnionic infection syndrome. Review pathologic criteria and clinical implications of maternal vascular underperfusion. Review pathologic criteria and clinical implications of fetal vascular obstruction (fetal thrombotic vasculopathy). Review pathologic criteria and clinical implications of chronic villitis.
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PLACENTAL DEVELOPMENT
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
IMPLANTATION
First differentiation event: morula to inner cell mass and outer trophectoderm.
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
Early Placental Development – Day 7.5
3 1
2
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
Early Placental Development – Day 9
Embryonic Pole
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
Early Placental Development – Day 13
1 – Completely embedded in endometrial stroma. 2 - Lacunae open into maternal spiral arteries – sinusoids. Utero- placental circulation established. 3 – Extraembryonic mesoderm layer forms and lines the cytotrophoblast layer (to become chorion). 4 – Amnionblast (derived from epiblast) will form separate layer amnion later. 5 – Connecting stalk will become UC. 6 – Primary villi form. 7 – chorionic cavity forms.
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
VASCULOGENESIS OF THE PLACENTA (Beginning day 14)
New vessels formed from mesodermic mesenchyme.
Cytotrophoblast cells invade through syncytiotrophoblast and results in altered differentiation of extravillous trophoblast (EVT).
EVT
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
Early Placental Development – Day 21
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
Villous Development
Archoring (primary) villi.
Branching to secondary and tertiary villi.
4th w 4th m
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From: Langman’s Medical Embryolgy 11th ed. TW Sadler
Overview of Placenta
8 w 12 w
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AMNIONIC FLUID INFECTION
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Acute Amniotic Fluid Infection
Ascending maternal bacterial infection.
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Histologic Staging of Amnionic Fluid Infection (Redline RW, et al. Ped Dev Pathol 6, 435-448, 2003)
Stage thought related to duration of infection!
Acute marginating choriodeciduitis
* *
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HISTOLOGIC STAGING OF ACUTE AMNIOTIC FLUID INFECTION MATERNAL INFLAMMATORY RESPONSE (look at membranes and at the chorionic plate) Stage 1 Subchorionitis (acute marginating choriodeciduitis) Stage 2 Acute chorioamnionitis Stage 3 Acute necrotizing chorioamnionitis FETAL INFLAMMATORY RESPONSE (look at umbilical cord & vessels and chorionic plate vessels) Stage 1 Acute umbilical phlebitis and/or chorionic plate vasculitis Stage 2 One or more umbilical arteries involved +/- vein & CP vessels Stage 3 Necrotizing funisitis or concentric perivasculitis Terms: FUNISITIS reserved for inflammation in Wharton’s jelly VASCULITIS reserved for inflammation in wall of fetal vessel
Histologic Staging of Amnionic Fluid Infection in the Placenta (Redline RW, et al. Ped Dev Pathol 6, 435-448, 2003)
Stage thought related to duration of infection and therefore likelihood of fetal infection!
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Normal Chorionic Plate
Opaque Chorionic Plate (Chorioamnionitis)
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Normal Placental Membranes
Maternal Inflammatory Response - Membranes Acute Necrotizing Chorioamnionitis (stage 3)
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Acute Chorioamnionitis, Stage 2
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Acute Marginating Choriodeciduitis or Subchorionitis (Stage 1)
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Maternal Inflammatory Response at the Chorionic Plate (Acute subchorionitis, chrorionitis, and amnionitis.)
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Approximation of timing of the infection based on maternal response: Stage 1 – acute subchorionitis 6-12h Stage 2 – acute chorioamnionitis 12-36h Stage 3 – necrotizing chorioamnionitis >36h Multiple factors can affect the actual timing. We do not put this in our reports.
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Acute umbilical arteri-s – stage 2
Acute umbilical phlebi-s – stage 1
Fetal Inflammatory Response Phlebitis (stage 1), arteritis or panvasculitis (stage 2), concentric panvasculitis or necrotizing vasculitis/funisitis (stage 3). Chorionic plate vasculitis (stage 1).
Acute necro-zing vasculi-s – stage 3
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AFI can increase the risk of marginal, subchorionic and retroplacental hemorrhages.
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NMH REPORT TEMPLATE FINDINGS CONSISTENT WITH AMNIONIC INFECTION SYNDROME:
MATERNAL INFLAMMATORY RESPONSE, STAGE ____. MEMBRANES WITH Pick one: ACUTE MARGINATING CHORIODECIDUITIS. ACUTE CHORIOAMNIONITIS. ACUTE NECROTIZING CHORIOAMNIONITIS.
CHORIONIC PLATE WITH Pick one: ACUTE SUBCHORIONITIS. ACUTE SUBCHORIONITIS AND CHORIONITIS. ACUTE SUBCHORIONITIS, CHORIONITIS, AND AMNIONITIS
FETAL INFLAMMATORY RESPONSE, STAGE ____. Pick which apply: ACUTE CHORIONIC VASCULITIS. ACUTE UMBILICAL PHLEBITIS. ACUTE UMBILICAL ARTERITIS. ACUTE UMBILICAL PANVASCULITIS WITH FUNISITIS.
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Candida Funisitis
From Dr. DB Singer
Can present as early neonatal sepsis. Most cases neonate does fine. We still consider this a critical value.
Peripheral umbilical microabscesses
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Clinical implications of amnionic fluid infection. Before 32 weeks: PPROM with preterm delivery and immature organ systems (intracranial hemorrhages, hyaline membrane disease, necrotizing enterocolitis, infection, etc., death (fetal pneumonia/sepsis)). Previable fetus less than 23 weeks.
Term fetus: Amnionic fluid infection common (between 5-25%) with no major sequelae in most cases. [2-3 fold increased risk of intubation, low APGAR, pneumonia, sepsis, seizures, respiratory distress, cerebral palsy]. Fetal inflammatory response (stage 2 or 3) is associated with CP and poor neurologic outcomes. Increased risk related to fetal infection, thrombi, hemorrhage (abruption), hypoxic-ischemic injury. Common organisms: GBS, other Strep, Staph, gram negatives (fusobacterium, H. flu, E. coli, others), Listeria, mixed flora, Candida.
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An example of an identifiable organism from placental pathology 32 year old G5P1031 at 25w3d by LMP delivered by crash C-section after presenting in preterm labor with advanced cervical dilation and secondary non-reassuring fetal heart tones. Fetal position was footling breech. Stable in NICU. Placenta received for pathologic assessment.
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