plasma proteins 1

8/3/2019 Plasma Proteins 1

1/46

Zco{lo Ztaxm`n{

Emnmtoc ztazmtx`m{ onh {mcmkxmhmvolzcm{

Io`{oc Gfox`d LH7 ZfH

Iok}cxp ai Lmh`k`nm# ]n`ymt{`xp ai BathonFotzmt{ D`akfml`{xtp Kfozxmt 80


2/46

Zco{lo `{ Adxo`nmh ital Kmnxt`i}emh Dcaah


3/46

Zco{lo y{. {mt}l

UDK{

TDK{

c`q}`h

kmcc{

{z`n dcaah

{mzotoxm `nxa 4 zotx{

Dcaah u`xf

onx`kaoe}conx

Kcaxxmh dcaah

[mt}l


4/46

[mzotox`an ai Kalzanmnx{

Zco{lo < Cm{{ Hmn{m

Fmloxakt`x

Zokgmh Kmcc{

Latm Hmn{m

Zcoxmcmx{ ! UDK{


5/46

Kalzanmnx{ ai Zco{lo

Dcaah zco{lo Kan{`{x{ ai2

Uoxmt 0:-

Zco{lo Ztaxm`n{ 9,6 -

Mcmkxtacpxm{ &No' ) Kc, ?-

Axfmt kalzanmnx{2

N}xt`mnx{ &m.e. Ec}ka{m onh ol`na ok`h{ Fatlanm{ &m.e. Katx`{ac# xfptav`nm

Uo{xm{ &m.e. ]tmo

Dcaah eo{m{ &m.e. KA4# A4


6/46

Zco{lo Ztaxm`n{

Zco{lo Ztaxm`n{2 O kalzcmv l`vx}tm xfox

`nkc}hm{ f}nhtmh{ ai ztaxm`n{

ocd}l`n ecad}c`n{

i`dt`naemn


7/46

Zco{lo Ztaxm`n{

Lo`nxo`n`ne kacca`h a{lax`k doconkm &ocd}l`n)

D}iimt`ne zF kfonem{

Xton{zatx ai loxmt`oc{ xfta}ef dcaah &{}kf o{

uoxmt,`n{ac}dcm fatlanm{)

Onx`dah`m{ &m.e. eollo ecad}c`n{#

`ll}naecad}c`n{)

Kcaxx`ne iokxat{ &m.e. i`dt`naemn)

Onx`ztaxmo{m{


8/46

[mzotox`an ai Zco{lo Ztaxm`n{

[ac}d`c`xp

[ocx`ne a}x

Mcmkxtazfatm{`{

@{amcmkxt`k Iak}{`ne

]{m ai onx`dah`m{


9/46


10/46


11/46

Itokx`an{ ai Zco{lo Ztaxm`n{Itokx`an ola}nx&-) k &e!c)

Ocd}l`n{2 ocd}l`n ztm,ocd}l`n&xton{xfptmx`n)

=4 =6 ;8

=:

M?,ecad}c`n{2 xfptav`n,d`nh`ne ecad}c`n#

xton{katx`n# M?,ok`h ecpkaztaxm`n# M?,onx`xtpz{`n#M?,c`zaztaxm`n &FHC)# M?,imxaztaxm`n

4.8 8.8 4,8

M4,ecad}c`n{2 fozxaecad`n# loktaecad}c`n#kmt}cazco{l`n

9 ?: = 0

I,ecad}c`n{2 xton{imtt`n# fmlazmv`n#c`zaztaxm`n &CHC)# i`dt`naemn# K,tmokx`ym ztaxm`n#

K; onh K8 kalzanmnx{ ai xfm kalzcmlmnx

{p{xml

6.= ?8.=

9 ??

G,ecad}c`n{2 @eE# @eL# @eO# @eH# @eM ?: 4? 6 ?=


12/46

Zacplatzf`{l ai Zco{lo Ztaxm`n{

Xfm ztm{mnkm ai xua at latm emnmx`k yotònx{ ai

xfm {olm ztaxm`n.

Xfm yotònx{ otm mnkahmh dp o {`necm cak}{.

Xfm yotònx ozzmot{ `n ox cmo{x ?- ai xfm

zaz}coxàn.

Xfm yotònx{ hìimt {cèfxcp `n xfm`t ol`na ok`h

{mq}mnkm.

Lètoxm hìimtmnxcp }nhmt mcmkxtazfatm{`{.


13/46

Ok}xm Zfo{m Ztaxm`n{

Cmymc{ ai kmtxo`n ztaxm`n{ `nktmo{m h}t`ne ok}xm`nicolloxatp {xoxm{

Cmymc oc{a `nktmo{m

kftan`k `nicolloxatp {xoxm{

Konkmt

Mcmyox`an yotp ital =:- xa ?::: iach

Xfm{m ztaxm`n{ zcop o tacm `n dahp{ tm{zan{m

xa `nicollox`an

Mvolzcm{2 K,tmokx`ym ztaxm`n# ?,onx`xtpz{`n#

fozxaecad`n


14/46

Foci,cìm ai Zco{lo Ztaxm`n{

Mokf ztaxm`n fo{ o kfotokxmt`{x`k foci cìm

Hmxmtl`noxàn ai foci,cìm

@{acoxm ztaxm`n, Codmc u`xf ?;?@

, Hmxmtl`nm `x{ tohàokx`y`xp

, `nbmkx `nxa o natloc {}dbmkx

, U`xfhtou dcaah {olzcm ox yotà}{x`lm `nxmtyoc{

Xfm x`lm iat tohàokx`y`xp xa hmkc`nm ital `x{ zmogyoc}m xa anm foci ai `x{ zmog yoc}m


15/46

La{x zco{lo ztaxm`n{ otm

ecpkaztaxm`n{


16/46


17/46

Ocd}l`n

9: - ai xfm xaxoc zco{lo ztaxm`n{.

Cmymc yot`m{ u`xf oem ;.8,8.5 e!?::lc

?4 etol{ otm ztah}kmh ho`cp `n xfm c`ymt4= - ai xfm xaxoc ztaxm`n {pnxfm{`{ dp c`ymt#

anm foci ai xfm {mktmxmh ztaxm`n{.

90 gHo &Anm zacpzmzx`hm kfo`n# =6= O. Ok`h{) Foci,c`im ~ 4: hop{


18/46

[pnxfm{`{ aiOcd}l`n

Ztmztaocd}l`n

{`enoc zmzx`hmZtaocd}l`n

fmvozmzx`hmOcd}l`n


19/46

90 gHo

Ocd}l`n [xt}kx}tm

Mcc`z{a`hoc {fozm

Zotxòc hèm{xàn u`xf ztaxmo{m xftmm halo`n{ Fèfcp zacot u`xf xftmm fphtazfad`k kcmix{ Onàn`k ox zF 5.8 u`xf 4: nmeox`ym kfotem{


20/46

Ocd}l`n `{ tm{zan{`dcm iat 6: - ai xfmKacca`hoc ztm{{}tm


21/46


22/46

O

D D

D

D

D

D

D`nh`ne ai ht}e{ xa ocd}l`n kon tm{}cx `n

ht}e,ht}e nxmtokx`an

O Donh otm xua ht}e{ xfox d`nh xa ocd}l`n

O

O

O

O

O

D


23/46

Ko4'

Ko4' Ko4'

Ko4'

Ko4'


24/46

Hmktmo{mh kankmnxtoxàn ai ocd}l`n

@nohmq}oxm {a}tkm ai ol`na ok`h{.Locn}xt`xàn onh l}{kcm uo{x`ne.

C`ymt h`{mo{mXaxoc ztaxm`n kon dm natloc & ecad}c`n# ocd}l`n)

Eo{xta`nxm{x`noc ca{{Cmogoem ai ic}`h ital `nicolmh at h`{mo{mh l}ka{o

Tmnoc h`{mo{m

Zmnmxtoxàn ai ocd}l`n xfta}ef ecalmt}c}{


25/46

Onocd}`nmlò

Od{mnkm aiOcd}l`n ital xfm zco{lo

Totm kanh`xàn

Hmimkx `n xfm ztakm{{`ne ailTNO aiocd}l`n

O}xa{aloc tmkm{{`ym `nfmt`xonkm

Lahmtoxm mhmloKalzmn{oxàn dp {pnxfm{`{ ai axfmt zco{lo

ztaxm`n{


26/46

Ztmocd}l`n

Lètoxm{ ofmoh ai ocd}l`n

Kald`nm{ u`xf

X8 &Xfptav`nm) onh X;

Tmx`nac d`nh`ne ztaxm`n [fatx foci cìm &4 Hop{)

[mn{`x`ym lotgmt ai zaat ztaxm`n

n}xt`xàn Hmktmo{mh n

Fmzox`k holoem

X`{{}m nmkta{`{


27/46

?,Onx`ztaxm`no{m

Oc{a gnaun o{ ?,onx`xtpz{`n

@nf`d`x{ xtpz{`n# mco{xo{m# onh axfmt ztaxmo{m{

~=4 gHo Ecpkaztaxm`n & ;08 O.Ok`h{ u`xf ; ac`ea{okkfot`hm kfo`n{)

> 0:- ai xfm ?itokx`an ai f}lon zco{lo

Zt`nk`zoc {mt`nm ztaxmo{m `nf`d`xat


28/46

?,Onx`ztaxm`no{m &zacplatzf`{l)

Lonp zacplatzf`k iatl{

Xfm lobat emnaxpzm `{ LL

O

ccmcm{Z

`

L

#Z

`

[

#Z

`

R

#Z

`

I

Hmi`k`mnkp kon hmymcaz o c}ne h`{mo{m&mlzfp{mlo)

@nh`y`h}oc{ u`xf RR emnaxpzm onh Z`[R

fmxmtarpeaxm{ @nh`y`h}oc{ u`xf L[ atLR emnaxpzm }{}occp nax

oiimkxmh


29/46

X`{{}m holoem `n ?,onx`xtpz{`n

hmi`k`mnkp ' z}clanotp `nicollox`an

Cm}gakpxm{


30/46

[lag`ne `n xaz ai ?,onx`xtpz{`n

hmi`k`mnkp

[zmkì`k lmxfàn`nm &lmx ;=6) `{ `nyacymh `n

d`nh`ne ?,onx`xtpz{`n xa ztaxm`no{m

[lag`ne av`h`rm{ xf`{ lmxfàn`nm

Av`h`rmh kon nax `nf`d`x ztaxm`no{m{

@nh`y`h}oc{ u`xf Z`R zfmnaxpzm ox fèfmt t`{g.


31/46

?,onx`xtpz{`n hmi`k`mnkp c`ymt h`{mo{m

Zacplmt`roxàn ai RR lacmk}cm{ `n xfm

mnhazco{l`k tmx`k}c}l ai fmzoxakpxm{

Oeetmeoxàn `{ h}m xa `nxmtokxàn dmxummn o

caaz `n anm lacmk}cm onh o ztal`nmnx ,

zcmoxmh {fmmx `n onaxfmt lacmk}cm.

?,onx`xtpz{`n `{ nax tmcmo{mh ital kmcc{


32/46

Caaz,{fmmx zcaplmt`rox`an

ai xfm RR lacmk}cm{

Lacmk}cm ai

xfm L

zfmnaxpzm

Ztal`nmnx ,zcmoxmh {fmmx `n

xfm R lacmk}cm{


33/46

Fozxaecad`n &Fz)

4 ecpkaztaxm`n &0:gHo) [pnxfm{`rmh lo`ncp dp fmzoxakpxm{

Xua g`nh{ ai zacpzmzx`hm kfo`n{ X

ua kfo`n{ Anm kfo`n

Xftmm zacplatzf`k iatl{ Fz ?,?# Fz 4,?# Fz 4,4

Zacplatzf`{l `{ o{{ak`oxmh u`xf lonp `nicolloxatph`{mo{m{.

Ok}xm zfo{m ztaxm`n Cmymc `n o yot`mxp ai `nicolloxatp {xoxm{#

oc{a `n d}tn# nmzftax`k {pnhtalm


34/46

Fozxaecad`n I}nkx`an

D`nh`ne ai itmm fmlaecad`n

?:- ai xfm Fd hmetohmh mokf hop `{ tmcmo{mh

`nxa xfm zco{lo

Fd &9= gHo) Fd2Fz Kalzcmv &?== gHo)

G`hnmp

G`hnmp ]zxogm dp c`ymt


35/46

Fozxaecad`n cmymc

Lmo{}tmh o{ Fd d`nh`ne kozok`xp Natloccp 8:,?6: le ai Fd d`nh`ne kozok`xp

Cmymc `n fmlacpx`k onml`o

Fd,Fz kalzcmv fo{ {fatxmt foci,c`im xfon xfox ai

Fzx?!4 ai Fz = hop{

x?!4 ai Fd,Fz 0: l`n}xm{

Fd,Fz kalzcmv `{ kcmotmh 6: x`lm{ io{xmt xfon Fz


36/46

?,imxaztaxm`n &OIZ)

Uo{ i`t{x h`{kaymtmh `n xfm {mt}l ai xfm imx}{.

Ymtp cau cmymc `n oh}cx.

Hmxmkxodcm `n xfm loxmtnoc dcaah `n ztmenonkp Mcmyoxmh cmymc `n {alm kanemn`xoc hmimkx{

Cau cmymc `nktmo{mh t`{g ai Haun{

{pnhtalm F`ef cmymc `n lonp ko{m{ ai c`ymt konkmt


37/46

4,Loktaecad}c`n

Cotem ztaxm`n 54: gHo Xmxtolmt ai 8 `hmnx`koc kfo`n{

6,?: - ai xfm xaxoc zco{lo ztaxm`n{

[pnxfm{`rmh dp Lanakpxm{

Fmzoxakpxm{

O{xtakpxm{ Cmymc yot`m{ u`xf oem# emnhmt

@nktmo{mh cmymc `n nmzftax`k {pnhtalm


38/46

4,Loktaecad}c`n

Zon ztaxm`no{m `nf`d`xat

Xtpz{`n# zmz{`n# zco{l`n# xftald`n

`nf`d`xat ai

Kaoe}cox`an I`dt`nacp{`{

Iatl{ kalzcmv u`xf xfm ztaxm`no{m iaccaumh dp

kcmotonkm

D`nh`ne xa lonp kpxag`nm{ &{`enoc lacmk}cm{)

onh h`tmkx`ne xfml xa xfm`t xotemx kmcc{


39/46

Kmt}cazco{l`n

4,ecad}c`n &?9: gHo)

D`nh{ kazzmt

X`efx d`nh`ne

0:- ai xfm zco{lo kazzmt & 9 oxal{!lacmk}cm)

Ocd}l`n d`nh{ xfm tmlo`n`ne ?:-

Fo{ av`ho{m okx`y`xp &imttav`ho{m)

Cau cmymc `n U`c{an h`{mo{m.


40/46

Kazzmt2 on m{{mnx`oc xtokm mcmlmnx

Ho`cp `nxogm 4,8 le

Dahp kanxo`n{ ~ ?:: le

Kaiokxat iat o n}ldmt ai mnrplm{ Kpxakftalm av`ho{m# ol`nm av`ho{m

Kon ocxmtnoxm dmxummn K}4' onh K}'

Mvkm{{ kazzmt kon dm fotli}c

Lmxoccaxf`anm`n{# o eta}z ai {locc ztaxm`n{

tme}coxm x`{{}m cmymc ai kazzmt

Kazzmt


41/46

K,Tmokt`ym Ztaxm`n

]nhmxmkxodcm `n fmocxfp `nh`y`h}oc{ @n zox`mnx{ u`xf h`ymt{m `nicolloxatp

h`{mo{m{

Ok}xm tfm}lox`k imymt# dokxmtòc `nimkxàn# ea}x .. X`{{}m holoem

Tmokx{ u`xf K {}d{xonkm & zacp{okkfot`hm `n

Zn}lakakk` onh lacmk}cot eta}z{ an o u`hmyot`mxp ai dokxmtò


42/46


43/46

Dcaah Aymty`mu

zco{lo~==- ai dcaah

F4A 04-

zco{lo ztaxm`n{ 5-`an{

n}x`tmnx{

uo{xm{

fatlanm{


44/46

Dcaah zco{lo

ztaxm`n{2

ocd}l`n{

9:- ai zco{lo ztaxm`n{

lohm `n c`ymtxton{zatx2

ioxxp ok`h{

fatlanm{axfmt {x}ii


45/46

Dcaah zco{lo

ztaxm`n{2

ecad}c`n{

;=- ai zco{lo ztaxm`n{

xua xpzm{`ll}naecad}c`n{

xton{zatx ecad}c`n{

ogo.# onx`dah`m{ &Od)

fatlanm,d`nh`ne &xfpta`h F)

lmxoccaoztaxm`n{ &`tan)

ozac`zaztaxm`n{ &c`z`h{)

{xmta`h,d`nh`ne &xm{xa{xmtanm)


46/46

Ko}{m{ ai hmktmo{mh zco{lo ocd}l`n2@. Hmktmo{mh {pnxfm{`{

O. locn}xtxàn

D. locod{atzxànK. ohyonkmh kftan`k c`ymt h`{mo{m

@@. Odnatloc h`{xt`d}xàn at h`c}xànO. aymtfphtoxànD. `nktmo{mh koz`ccotp zmtlmod`c`xp c`gm `n

{mzx`kmlò

@@@. Odnatloc mvktmxàn at hmetohoxànO. nmzftax`k {pnhtalmD. d}tn{K. fmlattfoemH. kmtxo`n koxodac`k {xoxm{

M. ca{{ ai ztaxm`n ital xfm hèm{x`ym xtokx

@Y. Totm kanemn`xoc hmimkx{O. fpzaocd}l`nmlò

D onocd}l`nmlò

plasma proteins 1

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