How DNA Finds Its Match and

Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV

Ana Milena Higuita RestrepoSchool of Health Sciences

Semestre IIIFebrary 20 / 2012

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Introduction

How DNA Finds Its Match- Part AScienceDaily (Feb. 8, 2012)

Kowalczykowski: •Single molecules of DNA in 1991 • 2001 helicase. •Kowalczykowski's lab: purification the protein made by the BRCA2 gene.

How DNA Finds Its Match-Part BScienceDaily (Feb. 8, 2012)

How DNA Finds Its Match-Part CScienceDaily (Feb. 8, 2012)

The RecA/DNA filament might be able to touch several different stretches of DNA simultaneously and thus shorten the time for the search.

How DNA Finds Its Match-Part DScienceDaily (Feb. 8, 2012)

Personal comment

As student it´s important to understand the mechanism of complementarity is developed between many sequences, and understand the reason so many pathologies. For this reason that scientific progress can be monitored at the development of genetic problems.

Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV- Part A

ScienceDaily (Feb. 14, 2012)

Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV- Part B

ScienceDaily (Feb. 14, 2012)

Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV- Part C

ScienceDaily (Feb. 14, 2012)

The chain of NDIs grow from special resin beads. The reactions run to right on the beads, attach pieces in the proper order and keep growing the molecules until it´s ready to cleave them off. It's mostly automated at this point.

Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV- Part D

ScienceDaily (Feb. 14, 2012)

Personal comment

This is a significant scientific advance news, which allows to understand how interactions through DNA can solve many scientific problems and diseases.

Medical utility

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Medical utility

• Studies in previous news, showing the relationship of the molecular processes of DNA with different genetic diseases and their proper prevention.

Medical utility

• In animals with defects in Rad51 don't even survive as embryos, and also the defects in some proteins associated with DNA repair are associated with an increased risk of cancer.

Medical utility

It's an important step along the path to someday creating drugs that can go after rogue DNA directly. Such drugs would be revolutionary in the treatment of genetic diseases, cancer or retroviruses such as HIV, which incorporate viral DNA directly into the body's DNA.

BIBLIOGRAPHY

How DNA Finds Its Match. ScienceDaily .Feb. 8, 2012 from http://www.sciencedaily.com/releases/2012/02/120208132309.htm

MARTINEZ S. LINA MARIA, Biología molecular. 6 ed. Medellin; UPB.fac. de medicina 2011, p 10-14;42-55.

Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV, ScienceDaily ;Feb. 14, 2012 from http://www.sciencedaily.com/releases/2012/02/120214134942.htm