RESEARCH PUBLICATIONS AND PRESENTATIONS

Peer-Reviewed Articles Published or in Press

1. Richards JB, Zheng HF, Spector TD. Genetics of Osteoporosis from Genome-Wide Association Studies: Advances and Challenges. Nature Reviews Genetics. In Press 2012/6/28. Solicited Review.

2. Li R, Brockschmidt FF, Kiefer AK, Stefansson H, Nyholt DR, Song K, Vermeulen SH, Kanoni S, Glass D, Medland SE, Dimitriou M, Waterworth D, Tung JY, Geller F, Heilmann S, Hillmer AM, Bataille V, Eigelshoven S, Hanneken S, Moebus S, Herold C, den Heijer M, Montgomery GW, Deloukas P, Eriksson N, Heath AC, Becker T, Sulem P, Mangino M, Vollenweider P, Spector TD, Dedoussis G, Martin NG, Kiemeney LA, Mooser V, Stefansson K, Hinds DA, Nöthen MM, Richards JB. Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. PLoS Genet. 2012 May;8(5):e1002746. Epub 2012 May 31. This paper was a “Most Viewed” paper in PLoS Genetics

3. Liu CT, Estrada K, Yerges-Armstrong LM, Amin N, Evangelou E, Li G, Minster RL, Carless MA, Kammerer CM, Oei L, Zhou Y, Alonso N, Dailiana Z, Eriksson J, García-Giralt N, Giroux S, Husted LB, Khusainova RI, Koromila T, Kung AW, Lewis JR, Masi L, Mencej-Bedrac S, Nogues X, Patel MS, Prezelj J, Richards JB, Sham PC, Spector T, Vandenput L, Xiao SM, Zheng HF, Zhu K, Balcells S, Brandi ML, Frost M, Goltzman D, González-Macías J, Karlsson M, Khusnutdinova EK, Kollia P, Langdahl BL, Ljunggren O, Lorentzon M, Marc J, Mellström D, Ohlsson C, Olmos JM, Ralston SH, Riancho JA, Rousseau F, Urreizti R, Van Hul W, Zarrabeitia MT, Castano-Betancourt M, Demissie S, Grundberg E, Herrera L, Kwan T, Medina-Gómez C, Pastinen T, Sigurdsson G, Thorleifsson G, Vanmeurs JB, Blangero J, Hofman A, Liu Y, Mitchell BD, O'Connell JR, Oostra BA, Rotter JI, Stefansson K, Streeten EA, Styrkarsdottir U, Thorsteinsdottir U, Tylavsky FA, Uitterlinden A, Cauley JA, Harris TB, Ioannidis JP, Psaty BM, Robbins JA, Zillikens MC, Vanduijn CM, Prince RL, Karasik D, Rivadeneira F, Kiel DP, Cupples LA, Hsu YH. Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res. 2012 Jun 12. doi: 10.1002/jbmr.1679.

4. Sanseau P, Agarwal P, Barnes MR, Pastinen T, Richards JB, Cardon LR, Mooser V. Use of genome-wide association studies for drug repositioning. Nat Biotechnol. 2012 Apr 10;30(4):317-20.

5. Zheng HF,* Tobias JH,* Duncan E,* Evans DM,* Eriksson J, Paternoster L, Yerges-Armstrong LM, Lehtimäki T, Bergström U, Kähönen M, Leo PJ, Raitakari O, Laaksonen M, Nicholson GC, Viikari J, Ladouceur M, Lyytikäinen LP, Medina-Gomez C, Rivadeneira F, Prince RL, Sievanen H, Leslie WD, Mellström D, Eisman JA, Movérare-Skrtic S, Goltzman D, Hanley DA, Jones G, St Pourcain B, Xiao Y, Timpson NJ, Smith GD, Reid IR, Ring SM, Sambrook PN, Karlsson M, Dennison EM, Kemp JP, Danoy P, Sayers A, Wilson SG, Nethander M, McCloskey E, Vandenput L, Eastell R, Liu J, Spector T, Mitchell BD, Streeten EA, Brommage R, Pettersson-Kymmer U, Brown MA, Ohlsson C,* Richards JB,* Lorentzon M.* WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk. PLoS Genet. 2012 Jul;8(7):e1002745. Epub 2012 Jul 5.

6. Medina-Gomez C, Kemp JP, Estrada K, Eriksson J, Liu J, Reppe S, Evans DM, Heppe DH, Vandenput L, Herrera L, Ring SM, Kruithof CJ, Timpson NJ, Zillikens MC, Olstad OK, Zheng HF, Richards JB, St Pourcain B, Hofman A, Jaddoe VW, Smith GD, Lorentzon M, Gautvik KM, Uitterlinden AG, Brommage R, Ohlsson C, Tobias JH, Rivadeneira F. Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus. PLoS Genet. 2012 Jul;8(7):e1002718.

7. K Estrada, U Styrkarsdottir, E Evangelou, Y Hsu, EL Duncan, EE Ntzani, L Oei, OME Albagha, N Amin, JP Kemp, DL Koller, G Li, C Liu, RL Minster, A Moayyeri, L Vandenput, D Willner, S Xiao, LM Yergesarmstrong, H Zheng, N Alonso, J Eriksson, CM Kammerer, SK Kaptoge, PJ Leo, G Thorleifsson, SG Wilson, JF Wilson, V Aalto, M Alen, AK Aragaki, T Aspelund, JR Center, Z Dailiana, DJ Duggan, M Garcia, N Garciagiralt, S Giroux, G Hallmans, LJ Hocking, L Bjerre, KA Jameson, R Khusainova, G Su, C Kooperberg, T Koromila, M Kruk, M Laaksonen, AZ Lacroix, S Hun, PC Leung, JR Lewis, L Masi, S Mencejbedrac, TV Nguyen, X Nogues, MS Patel, J Prezelj, LM Rose, S Scollen, K Siggeirsdottir, AV Smith, O Svensson, S Trompet, O Trummer, NM Van, J Woo, K Zhu, S Balcells, M Luisa, BM Buckley, S Cheng, C Christiansen, C Cooper, G Dedoussis, I Ford, M Frost, D Goltzman, M Karlsson, E Khusnutdinova, J Koh, P Kollia, B Lomholt, WD Leslie, P Lips, O Ljunggren, RS Lorenc, J Marc, D MellstroÃàM, B Obermayerpietsch, JM Olmos, U Petterssonkymmer, DM Reid, JA Riancho, PM Ridker, F Rousseau, P Eline, NLS Tang, R Urreizti, W Van, J Viikari, MT Zarrabeitia, YS Aulchenko, M Castanobetancourt, E Grundberg, L Herrera, T Ingvarsson, H Johannsdottir, T Kwan, R Li, R Luben, C MedinagMez, S Reppe, JI Rotter, G Sigurdsson, JBJ , D Verlaan, FMK , AR Wood, Y Zhou, KM Gautvik, T Pastinen, S Raychaudhuri, JA Cauley, DI Chasman, GR Clark, SR Cummings, P Danoy, EM Dennison, R Eastell, JA Eisman, V Gudnason, A Hofman, RD Jackson, G Jones, J Wouter, K Khaw, T LehtimaÃàKi, Y Liu, M Lorentzon, E Mccloskey, BD Mitchell, K Nandakumar, GC Nicholson, BA Oostra, M Peacock, HAP Pols, RL Prince, O Raitakari, IR Reid, J Robbins, PN Sambrook, P Chung, AR Shuldiner, FA Tylavsky, CM Van, NJ Wareham, L Adrienne, MJ Econs, DM Evans, TB Harris, A Wai, BM Psaty, J Reeve, TD Spector, EA Streeten, M Carola, U Thorsteinsdottir,* C Ohlsson,* D Karasik,* JB Richards,* MA Brown,* K Stefansson,* AG Uitterlinden,* SH Ralston,* JPA Ioannidis,* DP Kiel,* F Rivadeneira.* Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics. Nat Genet. 2012 Apr 15. 44(5):491-501 doi: 10.1038/ng.2249.

8. Berger C, Greene-Finestone LS, Langsetmo L, Kreiger N, Joseph L, Kovacs CS, Richards JB, Hidiroglou N, Sarafin K, Davison KS, Adachi JD, Brown J, Hanley DA, Prior JC, Goltzman D; the CaMos Research Group. Temporal trends and determinants of longitudinal change in 25-Hydroxyvitamin D and parathyroid hormone levels. J of Bone Mineral Research. 2012 Mar 9

9. Mather KJ, Christophi CA, Jablonski KA, Knowler WC, Goldberg RB, Kahn SE, Spector T, Dastani Z, Waterworth D, Richards JB, Funahashi T, Pi-Sunyer FX , Pollin TI, Florez JC,, and Franks PW,, for the Diabetes Prevention Program Research Group*. Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program. Diabetic Medicine, 2012 Mar 24. doi: 10.1111/j.1464-5491.2012.03662.x.

10. Z Dastani,* M-F Hivert,* N Timpson,* JRB Perry,* X Yuan,* RA Scott,* P Henneman,* I M. Heid,* JR Kizer,* L-P Lyytikainen,* C Fuchsberger,* T Tanaka, A P Morris, K Small, A Isaacs, M Beekman, S Coassin, K Lohman, L Qi, S Kanoni, J S Pankow, H-W Uh, Y Wu, A Bidulescu, L J Rasmussen-Torvik, CMT Greenwood, M Ladouceur, J Grimsby, AK Manning, C-T Liu, J Kooner, VE Mooser, P Vollenweider, KA Kapur, J Chambers, NJ Wareham, C Langenberg, R Frants, K Willems-vanDijk, BA Oostra, S M Willems, C Lamina, Thomas Winkler, BM Psaty, RP Tracy, J Brody, I Chen, J Viikari, M Kähönen, PP Pramstaller, M Evans, B St Pourcain, N Sattar, A Wood, S Bandinelli, Olga D. Carlson, JM Egan, S Böhringer, D van Heemst, L Kedenko, K Kristiansson, M-L Nuotio, B-M Loo, T Harris, M Garcia, A Kanaya, M Haun, N Klopp, HE Wichmann, P Deloukas, E Katsareli, DJ Couper, BB Duncan, M Kloppenburg, LS Adair, JB Borja, DIAGRAM+ Consortium, MAGIC Consortium, GLGC Investigators, MuTHER Consortium, JG Wilson, S Musani, X Guo, T Johnson, R Semple, TM Teslovich, MA Allison, S Redline, SG Buxbaum, KL Mohlke, I Meulenbelt, CM Ballantyne, GV Dedoussis, FB Hu, Y Liu, B Paulweber, TD Spector, PE Slagboom, L Ferrucci, A Jula, M Perola, O Raitakari, JC Florez, V Salomaa,** JG Eriksson, TM Frayling,** AA Hicks,** T Lehtimäki,** GD Smith,**, DS Siscovick,** F Kronenberg,** C van Duijn,** RJF Loos,** DM Waterworth,** JB Meigs,** J Dupuis,** JB Richards**. Novel Loci for Adiponectin Levels and their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic

Meta-Analysis of 45,891 Individuals. PLoS Genetics 2012 8(3): e1002607. doi:10.1371/journal.pgen.1002607

11. M Ladouceur, Z Dastani, YS Aulchenko, MG Ehm, CMT Greenwood, JB Richards. The empirical power of rare variant association methods: Results from Sanger sequencing in 1,998 individuals. PLoS Genetics 8(2): e1002496. doi:10.1371/journal.pgen.1002496. 2012. This paper was described as a Research Highlight by Nature Genetics and Nature Methods and was a “Most Viewed” paper in PLoS Genetics.

12. HF Zheng, TD Spector, JB Richards. Insights into the genetics of osteoporosis from recent genome-wide association studies. Expert Rev Mol Med. 2011 Aug 26;13:e28.

13. JL Min, JM Taylor, JB Richards, T Watts, FH Pettersson, J Broxholme, KR Ahmadi, GL

Surdulescu, E Lowy, C Gieger, C Newton-Cheh, M Perola, N Soranzo, I Surakka, CM Lindgren, J Ragoussis, AP Morris, LR Cardon, TD Spector, KT Zondervan. The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. PLoS One. 2011;6(7):e22070. Epub 2011 Jul 15.

14. P Arora*, B Garcia-Bailo*, Z Dastani*, D Brenner, A Villegas, S Malk, TD Spector, JB Richards,

A El-Sohemy, M Karmali, A Badawi. Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. BMC Med Genet. 2011 Jul 14;12(1):95. [Epub ahead of print].

15. LS Greene-Finestone, C Berger, M de Groh, DA Hanley, N Hidiroglou, K Sarafin, S Poliquin, J

Krieger, JB Richards, D Goltzman; CaMos Research Group. 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates. Osteoporosis International. 2011 May;22(5):1389-99. Epub 2010 Aug 21.

16. EL Duncan, P Danoy, JP Kemp, P Leo, E McCloskey, GC Nicholson, R Eastell, RL Prince, JA

Eisman, G Jones, PN Sambrook, IR Reid, EM Dennison, J Wark, JB Richards, AG Uitterlinden, TD Spector, C Esapa, RD Cox, SDM Brown, RV Thakker, KA Addison, LA Bradbury, JR Center, C Cooper, C Cremin, K Estrada, D Felsenberg, CC Glueer, J Hadler, MJ Henry, A Hofman, MA Kotowicz, J Makovey, SC Nguyen, TV Nguyen, JA Pasco, K Pryce, DM Reid, F Rivadeneira, C Roux, K Stefansson, U Styrkarsdottir, G Thorleifsson, R Tichawangana, DM Evans, MA Brown. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genetics. 2011 Apr;7(4):e1001372. Epub 2011 Apr 21.

17. M Ladouceur, WD Leslie, Z Dastani, D Goltzman, JB Richards. An Efficient Paradigm for

Genetic Epidemiology Cohort Creation. PLoS One. 2010 Nov 18;5(11):e14045.

18. V Panicker, SG Wilson, JP Walsh, JB Richards, SJ Brown, JP Beilby, AP Bremner, GL Surdulescu, E Qweitin, I Gillham-Nasenya, N Soranzo, EM Lim, SJ Fletcher, TD Spector. A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. American Journal of Human Genetics. 2010 Sep 10;87(3):430-5

19. TJ Wang*, F Zhang*, JB Richards*, B Kestenbaum*, JB van Meurs*, D Berry*, D Kiel, EA

Streeten, C Ohlsson, DL Koller, MR Jarvelin, JD Cooper, PF O’Reilly, DK Houston, NL Glazer, L Vandenput, M Peacock, J Shi, F Rivadeneira, MI McCarthy, P Anneli, IH de Boer, M Mangino, B Kato, DJ Smyth, SL Booth, PF Jacques, GL Burke, M Goodarzi, CL Cheung, M Wolf, K Rice, D Goltzman, N Hidiroglou, M Ladouceur, SL Hui, NJ Wareham, LJ Hocking, D Hart, NK Arden, C Cooper, S Malik, WD Fraser, AL Hartikainen, G Zhai, H Macdonald, NG Forouhi, RJF Loos, DM Reid, A Hakim, E Dennison, Y Liu, C Power, HE Stevens, L Jaana, RS Vasan, N Soranzo, J Bojunga, BM Psaty, M Lorentzon, T Foroud, TB Harris, A Hofman, JO Jansson, JA Cauley, AG Uitterlinden, Q Gibson, L Palotie, D Karasik, DS Siscovick, MJ Econs, SB Kritchevsky, JC Florez,

JA Todd*, J Dupuis*, E Hypponen*, TD Spector*. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jul 17;376(9736):180-8. Epub 2010 Jun 10.

20. Y-H Hsu,* MC Zillikens,* SG Wilson,* CR Farber,* S Demissie, N Soranzo, EN Bianchi, E

Grundberg, L Liang, JB Richards, K Estrada, Y Zhou, A van Nas, MF Moffatt, G Zhai, A Hofman, JB van Meurs, HAP Pols, RI Price, O Nilsson, T Pastinen, LA Cupples, AJ Lusis, EE Schadt, S Ferrari, AG Uitterlinden, F Rivadeneira,* TD Spector,* D Karasik,* DP Kiel*. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis related traits. PLoS Genetics. 2010 Jun 10;6(6):e1000977.

21. AWC Kung, SM Xiao, S Cherny, GHY Li, Y Gao, G Tso, K Lau, KDK Luk, J Liu, B Cui, MJ Zhang,

Z Zhang, J He, H Yue, W Xia, L Luo, S He, DP Kiel, D Karasik, YH Hsu, LA Cupples, S Demissie, U Styrkarsdottir, BV Halldorsson, G Sigurdsson, U Thorsteinsdottir, K Stefansson, JB Richards, G Zhai, N Soranzo, A Valdes, TD Spector, PC Sham. Association of JAG1 gene and its variant sequence with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. American Journal of Human Genetics. 2010 Feb 12;86(2):229-39. Epub 2010 Jan 21.

22. IM Heid, P Henneman, A Hicks, S Coassin, T Winkler, YS Aulchenko, C Fuchsberger, K Song,

MF Hivert, DM Waterworth, NJ Timpson, JB Richards, JR Perry, T Tanaka, N Amin, B Kollerits, I Pichler, BA Oostra, B Thorand, RR Frants, T Illig, J Dupuis, B Glaser, T Spector, J Guralnik, JM Egan, JC Florez, DM Evans, N Soranzo, S Bandinelli, OD Carlson, TM Frayling, K Burling, GD Smith, V Mooser, L Ferrucci, JB Meigs, P Vollenweider, KW Dijk, P Pramstaller, F Kronenberg, CM van Duijn. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals. Atherosclerosis. 2010;208:412-20. Epub 2009 Dec 2.

23. JB Richards, D Waterworth, S O’Rahilly, MF Hivert, RJF Loos, JRB Perry, T Tanaka, NJ

Timpson, RK Semple, N Soranzo, K Song, N Rocha, E Grundberg, J Dupuis, JC Florez, C Langenberg, I Prokopenko, R Saxena, R Sladek, Y Aulchenko, D Evans, G Waeber, J Erdmann, M-S Burnett, N Sattar, J Devaney, C Willenborg, GIANT Consortium, A Hingorani, JCM Witteman, P Vollenweider, C Hengstenberg, L Ferrucci, D Melzer, K Stark, J Deanfield, J Winogradow, M Grassl, AS Hall, JM Egan, JR Thompson, SL Ricketts, IR König, W Reinhard, S Grundy, H-E Wichmann, P Barter, R Mahley, A Kesaniemi, DJ Rader, MP Reilly, SE Epstein, AFR Stewart, CM Van Duijn, H Schunkert, K Burling, P Deloukas, T Pastinen, NJ Samani, R McPherson, G Davey Smith, TM Frayling, NJ Wareham, JB Meigs, V Mooser,* TD Spector.* A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11.

24. JB Richards, FK Kavvoura, F Rivadeneira, U Styrkársdóttir, K Estrada, BV Halldórsson, Y Hsu,

MC Zillikens, SG Wilson BH Mullins, NA MSc, YS Aulchenko, LA Cupples, P Deloukas, S Demissie, A Hofman, A Kong, D Karasik, JB van Meurs BA Oostra, HA Pols, G Sigurdsson, U Thorsteinsdottir, N Soranzo, FM Williams, Y Cupples, SH Ralston, G Thorleifsson, CM van Duijn DP Kiel, KS MD, AG Uitterlinden, JP Ioannidis, TD Spector, A Systematic Evaluation of 150 Candidate Genes for their Association with Osteoporosis and Osteoporotic Fracture in a Meta-Analysis of Genome-Wide Association Data. Annals of Internal Medicine. 2009 Oct 20;151(8):528-37.

25. F Rivadeneira,* U Styrkársdóttir,* K Estrada,* B Halldórsson,* YH Hsu,* JB Richards,* MC

Zillikens,* FK. Kavvoura, N Amin, YS. Aulchenko, LA Cupples, P Deloukas, S Demissie, E Grundberg, A Hofman, A Kong, D Karasik, JB van Meurs, B Oostra, T Pastinen, HAP Pols, G Sigurdsson, N Soranzo, G Thorleifsson, U Thorsteinsdottir, FMK Williams, SG Wilson, Y Zhou, SH Ralston, CM van Duijn, T Spector, DP Kiel, K Stefansson, JPA Ioannidis, AG Uitterlinden, for the GEFOS Consortium. Twenty bone mineral density loci identified by large-scale meta-analysis

of genome-wide association studies. Nature Genetics. 2009 Nov;41(11):1199-206. Epub 2009 Oct 4.

26. M Mangino*, JB Richards*, N Soranzo, G Zhai, A Aviv, AM Valdes, NJ Samani, P Deloukas, TD

Spector. A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. Journal of Medical Genetics. 2009 Jul;46(7):451-4. Epub 2009 Apr 8.

27. SG Wilson, MR Jones, BH Mullin, IM Dick, JB Richards, TM Pastinen, E Grundberg, O

Ljunggren, GL Surdulescu, F Dudbridge, KS Elliott, AC Cervino, TD Spector, RL Prince, Common sequence variation in FLNB regulates bone structure in women in the general population and FLNB mRNA expression in osteoblasts in vitro. Journal of Bone and Mineral Research. 2009 Dec;24(12):1989-97.

28. N Soranzo,* F Rivadeneira,* U Chinappen-Horsley,* I Malkina, JB Richards, N Hammond, L

Stolk, A Nica, M Inouye, A Hofman, J Stephens, E Wheeler, P Arp, R Gwilliam, PM Jhamai, S Potter, A Chaney, MJR Ghori, R Ravindrarajah, S Ermakov, K Estrada, H AP Pols, FM. Williams, WL McArdle, JB van Meurs, RJF. Loos, ET. Dermitzakis, KR Ahmadi, DJ Hart, WH Ouwehand, NJ Wareham, I Barroso, MS Sandhu, DP Strachan, G Livshits, TD Spector, AG Uitterlinden, P Deloukas. Meta-analysis of genome-wide scans for human adult stature in humans indentifies novel loci and differential effects with measures of skeletal frame size. PLoS Genetics. April 2009:5(4):1-13.

29. NJ Timpson, JH Tobias, JB Richards, EL Duncan, AM Sims, N Soranzo, P Whittaker, V

Kumanduri, G Zhai, B Glaser, J Eisman, Graeme Jones9, Geoff Nicholson, R Prince, E Seeman, TD Spector, MA Brown, L Peltonen, G Davey Smith, P Deloukas, DM Evans. Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Human Molecular Genetics. 2009 Apr 15;18(8):1510-7.

30. Skidmore PM, Cassidy A, Swaminathan R, Richards JB, Mangino M, Spector TD, Macgregor

AJ.An obesogenic postnatal environment is more important than the fetal environment for the development of adult adiposity: a study of female twins. American Journal of Clinical Nutrition. 2009 Aug;90(2):401-6.

31. G Zhai, JBJ van Meurs, G Livshits, I Meulenbelt, AM Valdes, N Soranzo, D Hart, F Zhang, BS Kato , JB Richards, FMK Williams, M Inouye, M Kloppenburg, P Deloukas, E Slagboom, A Uitterlinden, TD Spector. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. Journal of Medical Genetics. 2009 Sep;46(9):614-6. Epub 2009 Jun 8.

32. Cassidy A, Skidmore P, Rimm EB, Welch A, Fairweather-Tait S, Skinner J, Burling K, Richards

JB, Spector TD, Macgregor AJ. Plasma Adiponectin Concentrations Are Associated with Body Composition and Plant-Based Dietary Factors in Female Twins.

a. Journal of Nutrition. 2009 Feb;139(2):353-8.

33. JB Richards, X Yuan, F Geller, D Waterworth, V Bataille, D Glass, K Song, G Waeber, P Vollenweider, KK Aben, LA Kiemeney, B Walters, N Soranzo, U Thorsteinsdottir, A Kong, T Rafnar, P Deloukas, P Sulem, H Stefansson, K Stefansson, TD Spector, Vincent Mooser. Genome-Wide Association Study Reveals a Novel Locus for Male Pattern Baldness. Nature Genetics. Nov 2008;40(11):1281-4. This paper received lay press coverage from the Wall Street Journal, BBC, Globe and Mail, CNN and several hundred news organizations.

34. JB Richards,* F Rivadeneira,* M Inouye,* TM Pastinen, N Soranzo, SG Wilson, M Falchi, R

Gwilliam, KR Ahmadi, P Arp, P Whittaker, T Andrew, M Jhamai, V Kumanduri, M Moorhouse, JB

van Meurs, A Hofman, HAP Pols, D Hart, G Zhai, AM Valdes, BS Kato, BH Mullin, F Zhang, P Deloukas, AG Uitterlinden, TD Spector. Genome-Wide Association Study for Bone Mineral Density Reveals Genetic Variants Associated with Osteoporosis and Osteoporotic Fractures. The Lancet. 2008 May 3;371(9623):1505-12. This paper received lay press coverage from the Guardian, Telegraph, Reuters, US World News and Report and several other news organizations.

35. V Panicker, SG Wilson, TD Spector, SJ Brown, M Falchi, JB Richards, G Surdelescu, EM Lim, S

Fletcher and JP Walsh. Genetic loci linked to pituitary-thyroid axis setpoints: A genome-wide scan of a large twin cohort. Journal of Clinical Endocrinology & Metabolism. 2008 Sep;93(9):3519-23.

36. LA Langsetmo, S Morin, JB Richards, K S Davison, W P Olszynski, J C Prior, R Josse, D

Goltzman, and the CaMos Research Group. Effectiveness of antiresorptives for the prevention of non-vertebral low-trauma fractures in a population-based cohort of women. Osteoporosis International. 2009 Feb;20(2):283-90.

37. HE Whitson, L Sanders, CF Pieper, DT Gold, A Papaioannou, JB Richards, JD Adachi, KW

Lyles. Depressive symptomatology and fracture risk in community-dwelling older men and women. Aging Clinical and Experimental Research. 2008 Dec;20(6):585-92.

38. L Cherkas, J Hunkin, B Kato, JB Richards, JP Gardner, A Aviv, TD Spector. Physical Activity

and Leukocyte Telomere Length in Women. Archives of Internal Medicine. 2008;168(2):154-8. This paper received lay press coverage from the Times, New York Times, Washington Post, ABC News, CTV, Daily Mail, Associated Press and over 100 other news services.

39. G Zhai, D Hart, AM Valdes, B Kato, JB Richards, A Hakim, TD Spector. Natural History and Risk

Factors of Bone Loss in Postmenopausal Caucasian Women: A 15-Year Follow-Up Population-Based Study Osteoporosis International 2008 Aug;19(8):1211-7.

40. JB Richards, AM Valdes, JP Gardner, BS Kato, A Siva, M Kimura, X Lu, MJ Brown, A Aviv,

TD

Spector. Homocysteine Levels and Leukocyte Telomere Length. Atherosclerosis. 2008 Oct;200(2):271-7.

41. PMl Skidmore, A Cassidy, R Swaminathan, JB Richards, TD Spector, AJ Macgregor. Relation of

birth weight, BMI and change in size from birth to adulthood to insulin resistance in a female twin cohort. Journal of Clinical Endocrinolology Metabolism. 2008 Feb;93(2):516-20.

42. JB Richards, AM Valdes, JP Gardner, M Kimura, X Lu, R Swaminathan, A Aviv, TD Spector.

Increased Serum Vitamin D Levels are Associated with Increased Leukocyte Telomere Length in Women. American Journal of Clinical Nutrition. 2007 Nov;86(5):1420-5. This paper received lay press coverage from The Times, BBC, The Guardian and The Telegraph.

43. JB Richards, A Papaioannou, JD Adachi, L Joseph, HE Whitson, JC Prior, D Goltzman;

Canadian Multicentre Osteoporosis Study Research Group. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Archives of Internal Medicine. 2007 Jan 22;167(2):188-94. This paper received lay-press coverage from the New York Times, Washington Post, BBC, LA Times, Globe and Mail, Toronto Star, CNN and over 200 other news sources. This paper also lead to a review of the effect of anti-depressants on bone metabolism by the Food and Drug Administration of the USA.

44. JB Richards, AM Valdes, K Burling, UC Perks, TD Spector. Serum Adiponectin and Bone

Mineral Density in Women. Journal of Clinical Endocrinology and Metabolism. April 2007, 92(4):1517–23.

45. JB Richards, WD Leslie, L Joseph, K Siminoski, DA Hanley, JD Adachi, JP Brown, S Morin, A Papaioannou, RG Josse, JC Prior, KS Davison, A Tenenhouse, D Goltzman. Changes to Osteoporosis Prevalence According to Method of Risk Assessment. Journal of Bone Mineral Research. February 2007:22:228-34.

46. V Panicker, S Wilson, TD Spector, SJ Brown, M Falchi, JB Richards, GL Surdulescu, EM Lim,

SJ Fletcher and JP Walsh. Heritability of serum TSH, free T4 and free T3 concentrations: A study of a large UK twin cohort. Clinical Endocrinology. 2008 Apr;68(4):652-9.

47. AM Valdes, JB Richards, A Aviv, JP Gardner, R Swaminathan, M Kimura, X Lu, TD Spector.

Telomere Length in Leukocytes Correlates with Bone Mineral Density and is Shorter in Women with Osteoporosis. Osteoporosis International. 2007 Sep;18(9):1203-10.

48. JB Richards, LF Cherkas, TD Spector. An analysis of which anti-osteoporosis therapeutic

regimen would improve compliance in a population of elderly adults. Current Opinions in Medical Research. 2007 Feb;23(2):293-9.

49. JB Richards, L Joseph, K Schwartzman, N Kreiger, A Tenenhouse, D Goltzman. The effect of

cyclooxygenase-2 inhibitors on bone mineral density: Results from the Canadian Multi-Centre Osteoporosis Study. Osteoporosis International. 2006 Sep;17(9):1410-9.

50. B Richards, R Kozak, P Brassard, D Menzies, K Schwartzman. Tuberculosis surveillance among

new immigrants in Montreal. International Journal of Tuberculosis and Lung Disease. 2005 Aug;9(8):858-64.

51. KC Carter, S Byck, PJ Waters, B Richards, PM Nowacki, R Laframboise, M Lambert, E Treacy,

CR Scriver. Mutation at the Phenylalanine Hydroxylase Gene (PAH) and its use to document population genetic variance: Québec Experience. European Journal of Human Genetics. 1998;6:61-70. Using haplotypes of the PAH gene, we described a founder effect and quantified the genetic variation within the Québec population.

Invited Editorials

1. Z Dastani, JB Richards. Is Coronary Artery Calcification at the Intersection of Vitamin D and Coronary Artery Disease? Arteriosclerosis, Thrombosis and Vascular Biology. 2010;30:2329-2330. [Solicited by Arteriosclerosis, Thrombosis and Vascular Biology]

2. JB Richards, D Goltzman. A Bone to Pick with Proton Pump Inhibitors: Balancing Benefits and

Potential Fracture Risks. Canadian Medical Association Journal. 2008 Aug 12;179(4):306-7. Selected Abstracts and Oral Presentations 2012 Hanieh Yaghootkar, Liling Warren, Debbie Lawlor, Robert Scott, Zari Dastani, Marie-France

Hivert, Peter Hennman, Claudia Langenberg, Christopher Gillson, Aurelian Bidulescu, Ying Wu, Leo-Pekka Lyytikainen, Christie Mitchell Ballantyne, Lyudmyla Kedenko, Ruth Loos, Olli Raitakari, Matt Allison, Alan Sinaiko, Bernhard Paulweber, Karen Mohlke, Cornelia van Duijn, Terho Lehtimaki, Sarah Buxbaum, John Brent Richards, Jim Pankow, James Meigs, Nick Wareham, Markku Laakso, Mark Walker, Colin Palmer , Andrew Morris, Dawn Waterworth, Tim Frayling. Mendelian Randomization Studies To Understand the Role for Reduced Adiponectin Levels in Insulin Resistance or Type 2 Diabetes. American Diabetes Association. Philadephia, USA, June 8, 2012. POSTER

2011 Rebecca Jackson*, Andrea LaCroix, Aaron Aragaki, David Duggan, Chris Carlson, JB Richards,

Z Dastani, T Spector, J Eisman, Tuan Nguyen, Stuart Ralston, Eugene McCloskey, Emma Duncan, Geoffrey Nicholson, William Leslie, David Goltzman, Subha Krishnan, Charles Kooperberg. Genome-wide Association Study of Hip Fracture Suggests Loci in Biological

Pathways Associated with Bone Remodeling. American Society of Bone and Mineral Research, San Diego, USA, Sep 18, 2011. POSTER R Jackson, A LaCroix, A Aragaki, D Duggan, C Carlson, JB Richards, Z Dastani, T Spector, J Eisman, T Nguyen,S Ralston, E McCloskey, E Duncan, G Nicholson, W Leslie, D Goltzman, S Krishnan,C Kooperberg. Genome-Wide Association Meta-Analysis of Cortical Volumetric BMD Identifies Three Known and One Novel Bone-Related Loci. American Society of Bone and Mineral Research, San Diego, USA, Sep 18, 2011. POSTER YH Hsu, X Chen, D Kiel, JB Richards, C Elks, J Cauley, K Estrada, M Econs, K Lunetta, K Ong, J Perry, F Rivadeneira, L Stolk, T Spector, A Uitterlinden, M Zillikens, J Murabito, D Karasik. Pleiotropic Genetic Determinants of BMD and Ages at Menarche and Natural Menopause: Multivariate Genome-Wide Association Meta-Analyses. American Society of Bone and Mineral Research, San Diego, USA, Sep 18, 2011. POSTER L Oei, HF Zheng, E Ntzani, K Estrada, P Ridker, M Garcia, YH Hsu, T Lehtimaki, S Trompet, S Kaptoge, S Wilson, Y Liu, J Eriksson, N Amin, A Kung, K Tsilidis, C Medina-Gomez, L Rose, A Vernon-Smith, CT Liu, J Viikari, Al Moayyeri, R Minster, M Lorentzon, SM Xiao, N Wareham, V Aalto, T Aspelund, W Leslie, D Goltzman, S Cummings, L Cupples, E Evangelou, KT Khaw, R Luben, O Raitakari, K Siggeirsdottir, C van Duijn, J Cauley, D Karasik, P Sham, M Zillikens, C Ohlsson, T Harris, T Spector, J Reeve, J Jukema, J Ioannidis, M Kahonen, D Kiel, V Gudnason, A Uitterlinden, D Chasman, JB Richards, F Rivadeneira. Large-scale meta-analyses of Genome-Wide Association Studies for Fracture Risk. American Society of Bone and Mineral Research, San Diego, USA, Sep 18, 2011. POSTER K Estrada, E Evangelou, Y H Hsu, U Styrkarsdottir, C T Liu, A Moayyeri, S Kaptoge, E Duncan, D Evans, N Amin, L Oei, U Pettersson, T O’Neill, J Riancho, O Ljunggren, F Rousseau, W Leslie, D Goltzman, B Obermayer, B Langdahl, X Nogues, R Prince, P Lips, S Cheng, J Marc, G Dedoussis, P Kollia, M L Brandi, L Hocking, R Khusainova,C Cooper, R Jackson, T Lehtimaki, J M Koh, C Christiansen, J Eisman, N Tang, D Chasman, V Gudnason, S Trompet, P M Ridker, D Kiel, D Karasik, O Albagha, M Brown, T Spector, M Zillikens, C Ohlsson, G Thorleifsson,J Reeve, L Vandenput, R Minster, C Kammerer, L Yerges-Armstrong, JB Richards, J Cauley, A Kung, D Koller, J Ioannidis, S Ralston, A Uitterlinden, F Rivadeneira. Novel Genetic Factors and Biological Pathways Influencing BMD and Risk of Fracture. American Society of Bone and Mineral Research, San Diego, USA, Sept 17, 2011. POSTER D Koller, D Karasik, HF Zheng, L Yerges-Armstrong, CT Liu, D Lai, K Estrada, F Rivadeneira, A Uitterlinden, S Giroux, F Rousseau, S Czerwinski, B Towne, M Econs, B Mitchell, JB Richards, D Kiel, T Foroud. Meta-analysis of Genome-wide Association Studies in Premenopausal White Women Identifies Variants in WNT16, ESR1, and Novel BMD Loci. American Society of Bone and Mineral Research, San Diego, USA, Sept 17, 2011. POSTER C Berger, L Greene-Finestone, L Langsetmo, L Joseph, N Kreiger, JB Richards, C Kovacs, K Sarafin, K S Davison, J Adachi, J Brown, D Hanley, D Goltzman. Temporal Trends in 25-Hydroxyvitamin D levels and parathyroid hormone in a population-based study. American Society of Bone and Mineral Research, San Diego, USA, Sept 17, 2011. POSTER HF Zheng, L Yerges-Armstrong, J Eriksson, E Duncan, B Mitchell, C Ohlsson, E Streeten, M Lorentzon, JB Richards. Large-scale Meta-analysis of Genome-Wide Association Studies for Bone Mineral Density at Radius. American Society of Bone and Mineral Research, San Diego, USA, Sept 16, 2011. POSTER SG Wilson, JB Richards, JR Lewis, SJ Brown, S Chew, TD Spector. Copy number variation at 9q34 is associated with bone mineral density. Functional Genomics and Systems Biology Conference, Cambridge, UK, Nov 28, 2011

C Xu, M Ladouceur, JB Richards, A Ciampi, C Greenwood. Association tests for rare variants based on regularized regression methods. 12

th International Congress of Human Genetics

(ICHG)/American Society of Human Genetics (ASHG) 61st

Annual Meeting, Montreal, QC, October 11-15, 2011. [Abstract submitted May 31, 2011]. POSTER. H. L. Oei, H.-F.Zheng, E. Ntzani, K. Estrada, P. M. Ridker, M. Garcia, Y.-H. Hsu, T. Lehtimäki, S. Trompet, S. Kaptoge, S. Wilson, Y. Liu, J. Eriksson, A. Kung, A. Vernon-Smith, C.-T. Liu, J. Viikari, R. L. Minster, N. Wareham, V. Aalto, S. A. Cummings, K.-T. Khaw, J. A. Cauley, P. C. Sham, T. Spector, J. Ioannidis, D. P. Kiel, D. Chasman, J. B. Richards, F. Rivadeneira. Large-scale meta-analysis of Genome-Wide Association Studies (GWAS) for fracture risk: the GEFOS Consortium. 12

th International Congress of Human Genetics (ICHG)/American Society of

Human Genetics (ASHG) 61st

Annual Meeting, Montreal, QC, October 11-15, 2011. POSTER. H.-F. Zheng, L. Yerges-Armstrong, J. Eriksson, E. Duncan, B. Mitchell, C. Ohlsson, E. Streeten, M. Lorentzon, J. B. Richards. Large-scale Meta-analysis of Genome-Wide Association Studies for Bone Mineral Density at Radius identified Susceptibility Locus at Wnt16. 12

th International

Congress of Human Genetics (ICHG)/American Society of Human Genetics (ASHG) 61st

Annual Meeting, Montreal, QC, October 11-15, 2011. POSTER. B. Gottlieb, C. Alvarado, C. Wang, B. Gharizadeh, F. Babrzadeh, B. Richards, M. Basik, L. K. Beitel, M. Trifiro. Confronting the Problem of Genetic Heterogeneity in Cancer Tissues: Investigating the Role of the Androgen Receptor Gene in Breast Cancer Ontogeny and Treatment.12

th International Congress of Human Genetics (ICHG)/American Society of

Human Genetics (ASHG) 61st

Annual Meeting, Montreal, QC, October 11-15, 2011. POSTER.

R. Li, F. Brockschmidt, A. Kiefer, H. Stefansson, D. R. Nyholt, K. Song, S. H. Vermeulen, S. Kanoni, D. Glass, D. Waterworth, F. Geller, S. Hanneken, S. Moebus, C. Herold, G. W. Montgomery, P. Deloukas, N. Eriksson, A. C. Heath, T. Becker, M. Mangino, P. Vollenweider, T. D. Spector, G. Dedoussis, N. G. Martin, L. A. Kiemeney, V. Mooser, K. Stefansson, D. A. Hinds, M. M. Nöthen, J. B. Richards. Identification of 6 Novel Susceptibility Loci for Androgenetic Alopecia and Their Association with Common Disease: A Genome-Wide Association Study. 12

th

International Congress of Human Genetics (ICHG)/American Society of Human Genetics (ASHG) 61

st Annual Meeting, Montreal, QC, October 11-15, 2011. POSTER.

M. Ladouceur, Z. Dastani, Y. S. Aulchenko, M. T. Greenwood, J. B. Richards. The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals. 12

th International Congress of Human Genetics (ICHG)/American Society of

Human Genetics (ASHG) 61st

Annual Meeting, Montreal, QC, October 11-15, 2011. POSTER. Z. Dastani, D. Goltzman, T. Wang, L. Fu, D. P. Kiel, D. Cole, B. Richards. Influence of Genetic Variants on Response to Vitamin D Administration. 12

th International Congress of Human

Genetics (ICHG)/American Society of Human Genetics (ASHG) 61st

Annual Meeting, Montreal, QC, October 11-15, 2011. POSTER.

M Ladouceur, Z Dastani, Y Aulchenko, MG Ehm, C Greenwood, JB Richards, What is the power to associate rare variants with continuous traits? Results from Sanger sequencing seven genes in 1,998 individuals. 6

th Annual Canadian Genetic Epidemiology and Statistical Genetics

Meeting. King City, ON, May 11-13, 2011. PODIUM PRESENTATION. Z Dastani, NJ Timpson, JRB Perry, M-F Hivert, G Davey Smith, L-P Lyytikainen, J Pankow, TM

Frayling, JR Kizer, DS Siscovick, C Greenwood, Y Wu, M Ladouceur, KL Mohlke, J Wilson, M Beekman, L Qi, F Hu, R Loos, G Dedousi, I Meulenbelt, T Kilpelainen, C Van Duijn, F Kronenberg, A Hicks, T Lehtimäki, D Waterworth, JB Meigs, B Richards. Meta-analysis of 23 studies containing 45,891 individuals from three ethnicities for adiponectin levels identifies loci influencing risk of type 2 diabetes and metabolic syndrome. 6

th Annual Canadian Genetic

Epidemiology and Statistical Genetics Meeting, King City, ON, May 11-13, 2011, PODIUM PRESENTATION.

2010 Z Dastani, J Dupuis, M Hivert, J Meigs, N Timpson, John Perry,et al,JB Richards (Supervisor).

A large multinational genome-wide association study identifies novel loci that influence adiponectin levels. The American Society of Human Genetics 60

th Annual Meeting,

Washington DC, November 5th, 2010. PODIUM PRESENTATION.

K. Estrada, E. Evangelou, Y. H. Hsu, U. Styrkarsdottir, C. T. Liu, A. Moayyeri, S. Kaptoge, E. Duncan, N. Amin, D. Kiel, D. Karasik, O. Albagha, M. Brown, R. L. Minster, M. C. Zillikens, C. Ohlsson, G. Thorleifsson, J. Reeve, L. Vandenput, T. Spector, A. G. Uitterlinden, L. M. Yerges-Armstrong, J. B. Richards, N. Glazer, A. Kung, D. Koller, K. Stefansson, J. Loannidis, S. Ralston, F. Meta-analysis of genome-wide association studies for bone-mineral-density (BMD) identifies 34 loci regulating BMD and a novel locus for fracture risk. The American Society of Human Genetics 60

th Annual Meeting, Washington DC, November 5

th, 2010. PLATFORM

PRESENTATION.

M. A. Brown, E. L. Duncan, P. Danoy, J. Kemp, P. Leo, B. Richards, F. Rivadeneira, T. D. Spector, A. G. Uitterlinden, J. Wark, E. Dennison, R. Eastell, K. Estrada, G. Jones, E. McCloskey, G.Nicholson, R. L. Prince, P. N. Sambrook, J. A. Eisman, D. M. Evans. Genomewide association study demonstrates the power of extreme truncate selection, identifying novel genes controlling bone mineral density and fracture. The American Society of Human Genetics 60

th Annual

Meeting, Washington DC, November 4th, 2010. POSTER.

M. Ladouceur, C. Greenwood, Y. Aulchenko, B. Richards. Novel methods for detecting associations between continuous trait and rare variants: Application to the 1000 genome project. The American Society of Human Genetics 60

th Annual Meeting, Washington DC, November

3rd

, 2010. POSTER.

K. Estrada, G. Thorleifsson, E. Evangelou, D. Koller, J.B. Richards, L. Yerges-Armstrong, L. Vandenput, N. Amin, N. Glazer, O. Albagha, R. Minster, S. Kaptoge, S. Xiao, YH Hsu, A. G. Uitterlinden, A. Kung, C. Kammerer, C. Ohlsson, CMV Duijn, D Evans, D Karasik, D Kiel, E Streeten, E Duncan, J Cauley, JF Wilson, J Robbins, J Reeve, M Zillikens, EMC Rotterdam, M Brown, M Lorentzon, M Econs, M Peacock, P Sham, S Wilson, S Ralston, T Harris, T Spector, U Thorsteinsdottir, YM Liu, J Loannidis, U Styrkarsdottir, F Rivadeneira. Meta-analysis of Genome-wide Association Studies Identifies 34 loci that Regulate BMD with Evidence of Both Site Specific and Generalized Effects: the GEFOS Consortium. American Society for Bone and Mineral

Research Annual Meeting, Toronto, ON, October 18th, 2010. PLATFORM PRESENTATION. E. Duncan, P. Danoy, J. Kemp, P. Leo, B. Richards, T. Spector, F. Rivadeneira, A. Uitterlinden, J. Wark, E. Dennison, G. Jones, R. Prince, J. Eisman, P. Sambrook, G. Nicholson, R. Eastell, E. McCloskey, D. Evans, M. Brown. Genomewide Association Study Using Extreme Truncate Selection Identifies Novel Genes Controlling Bone Mineral Density. American Society for Bone and

Mineral Research Annual Meeting, Toronto, ON, October 17th 2010. POSTER.

YH Hsu, T Beck, SJ Brown, J Cauley, K Estrada, N Glazer, S Kaptoge, D Kiel, B Richards, F Rivadeneira, J Robbins, N Soranzo , T Spector, E Streeten, A Uitterlinden, S Wilson, L Yerges-Armstrong, C Zillikens, D. Karasik. Meta-analysis of Genome-Wide Association Study (GWAS) Identifies Several Genes for Hip Bone Geometry in Caucasians: The Genetic Factors for Osteoporosis (GEFOS) Consortium. American Society for Bone and Mineral Research Annual Meeting, Toronto, ON, October 16th, 2010. PLATFORM PRESENTATION C Berger, L Langsetmo, N Kreiger, L Greene-Finestone, C Kovacs, B Richards, N Hidiroglou, K Sarafin, KS Davison, J Adachi, J Brown, D Hanley, D Goltzman. Temporal Trends and Determinants of Longitudinal Change in 25-Hydroxyvitamin D Levels in a Population-based

Study. American Society for Bone and Mineral Research Annual Meeting, Toronto, ON, October 16th, 2010. POSTER.

2009 F. Rivadeneira, U. Styrkarsdottir, K. Estrada, B. V. Halldorsson, Y. H. Hsu, J. B. Richards, M. C.

Zillikens, F. K. Kavvoura, S. H. Ralston, U. Thorsteinsdottir, C. M. van Duijn, T. Spector, D. P. Kiel, K. Stefansson, J. P. A. Ioannidis, A. G. Uitterlinden. Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies. The American Society of Human Genetics 59

th Annual Meeting, Honolulu, Hawaii, October 24, 2009.

PLATFORM PRESENTATION

YH Hsu, AG. Uitterlinden, SG. Wilson, S. Demissie, MC. Zillikens, SJ. Brown, K. Estrada, RI.Price, N. Soranzo, HA. Pols, J. van Meurs, JB. Richards, LA. Cupples, TD. Spector, DP. Kiel, F. Rivadeneira, D. Karasik. Meta-analysis of Genome-Wide Association Scans Identifies CARD11 as a Determinant of Bone Strength in Caucasian Women: The Genetic Factors For Osteoporosis (GEFOS). The American Society of Human Genetics 59

th Annual Meeting, Honolulu, Hawaii,

Oct 21, 2009. POSTER.

Yi-Hsiang Hsu, D. Karasik, D. Kiel, T. Beck, J. Van Meurs, H. Pols, M. Zillikens, S. Brown, N Soranzo, B. Richards, K. Estrada, Serkalem Demissie, LA Cupples, R. Price, T. Spector, A. Uitterlinden, S. Wilson, F. Rivadeneira. Meta-analysis of Genome-Wide Association (GWA) Scans Identifies CARD11 as a Determinant of Bone Strength in Caucasian Women: The Genetic Factors For Osteoporosis (GEFOS) Consortium. American Society for Bone and Mineral Research 31st Annual Meeting, Denver, Colorado, September 15, 2009. PODIUM PRESENTATION.

JB Richards, FK Kavvoura, FK Rivadeneira, U Styrkársdóttir, K Estrada, BV Halldórsson, YH Hsu, MC Zillikens, SG Wilson, B Mullin, N Amin, Y Aulchenko, LA Cupples, P Deloukas, S Demissie, A Hofman, A Kong, D Karasik, JB van Meurs, B Oostra, HAP Pols, G Sigurdsson, U Thorsteinsdottir, N Soranzo, FMK Williams, Y Zhou, SH Ralston, G Thorleifsson, CM van Duijn, DP Kiel, K Stefansson, AG Uitterlinden, JPA Ioannidis, TD Spector. A Systematic Evaluation of 150 Candidate Genes for their Association with Osteoporosis and Osteoporotic Fracture in a Meta-Analysis of Genome-Wide Association Data. European Calcified Tissue Society, Vienna, Austria, May 26

th, 2009. PODIUM PRESENTATION

JB Richards, MF Hivert et al. Genome-Wide Association Study Reveals Genetic Variants in ARL15 Associated with Adiponectin Levels and Coronary Heart Disease. McGill University Endocrine Division Annual Retreat, May 14

th, 2009. PODIUM PRESENTATION

JB Richards, FK Kavvoura, F Rivadeneira, ,U Styrkársdóttir, K Estrada, BV Halldórsson, Y Hsu, MC Zillikens, SGWilson, BH Mullin, N Amin, YS Aulchenko, LA Cupples, P Deloukas, S Demissie, A Hofman, A Kong, D Karasik, JB van Meurs, BA Oostra, HAP Pols, G Sigurdsson, U Thorsteinsdottir, N Soranzo, FMK Williams, Y Zhou, SH Ralston, G Thorleifsson, CM van Duijn, DP Kiel, K Stefansson, AG Uitterlinden, JPA Ioannidis, TD Spector, for the Genetic Factors For Osteoporosis (GEFOS) Consortium. A Systematic Evaluation of 147 Candidate Genes for their Association with Osteoporosis and Osteoporotic Fracture in a Meta-Analysis of Genome-Wide Association Data.European Calcified Tissue Society, Barcelona, Spain, March 22

nd, 2009.

PODIUM PRESENTATION 2008 J. L. Min, J. M. Taylor, J. B. Richards, T. Watts, J. Broxholme, F. Pettersson, K. R. Ahmadi, I.

Ragoussis, A. P. Morris, T. D. Spector, L. R. Cardon, K. T. Zondervan. The use of genome-wide eQTL associations to identify novel genetic pathways involved in complex traits. American Society of Human Genetics 58th Annual Meeting, Philadelphia, PA, November 14

th, 2008.

POSTER.

JB Richards. Insights into Aging-Related Disease from Genome-Wide Association Studies.Canadian Institutes of Health Research Institutes of Aging and Genetics New Investigator Meeting. Toronto, ON, November 2008.Podium Presentation.

JB Richards, X Yuan, F Geller, D Waterworth, V Bataille, D Glass, K Song, G Waeber, P Vollenweider, KK Aben, LA Kiemeney, B Walters, N Soranzo, U Thorsteinsdottir, A Kong, T Rafnar, P Deloukas, P Sulem, HStefansson, K Stefansson, TD Spector, Vincent Mooser. Genome-Wide Association Study Reveals a Novel Locus for Male Pattern Baldness. American Society of Human Genetics 58th Annual Meeting, Philadelphia, PA, November 14th 2008. Podium Presentation.

JB Richards, F Rivadeneira, M Inouye, TM Pastinen, N Soranzo, SG Wilson, M Falchi, R Gwilliam, KR Ahmadi, P Arp, P Whittaker, T Andrew, M Jhamai, V Kumanduri, M Moorhouse, JB van Meurs, A Hofman, HAP Pols, D Hart, G Zhai, AM Valdes, BS Kato, BH Mullin, F Zhang, P Deloukas, AG Uitterlinden, TD Spector. Genome-Wide Association Study for Bone Mineral Density Reveals Genetic Variants Associated with Osteoporosis and Osteoporotic Fractures. . 30

th American Society for Bone and Mineral Research Annual Meeting, Montréal, QC,

September 13th, 2008. POSTER.

F. Rivadeneira, F. Kavvoura, D. Karasik, JB. Richards, B. Halldórsson, Y. Hsu, S. Demissie, A. Cupples, C. Zillikens, C. van Duijn, K. Estrada, J. van Meurs, H. Pols, U. Thorsteinsdottir, M. Brown, T. Spector, S. Ralston, D. Kiel, J. Ioannidis, U. Styrkársdóttir, A. Uitterlinden. Large-scale Meta-analysis of Genome-wide Association (GWA) Scans for Osteoporosis Traits: the GEFOS Consortium. 30

th American Society for Bone and Mineral Research Annual Meeting,

Montréal, QC, September 13th, 2008. Concurrent Oral.

JB Richards, F Rivadeneira, M Inouye, TM Pastinen, N Soranzo, SG Wilson, M Falchi, R Gwilliam, KR Ahmadi, P Arp, P Whittaker, T Andrew, M Jhamai, V Kumanduri, M Moorhouse, JB van Meurs, A Hofman, HAP Pols, D Hart, G Zhai, AM Valdes, BS Kato, BH Mullin, F Zhang, P Deloukas, AG Uitterlinden, TD Spector. Genome-Wide Association Study for Bone Mineral Density Reveals Genetic Variants Associated with Osteoporosis and Osteoporotic Fractures. CIHR Canadian Genetic Epidemiology & Statistical Genetics Meeting, Toronto, ON, April 30

th, 2008. Podium Presentation.

Richards JB, Papaioannou A, Adachi JD, Joseph L, Whitson HE, Prior JC, Goltzman D, “The Impact of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture”. European Society of Clinical and Economic aspects of Osteoporosis and Osteoarthritis, Istanbul, Turkey, April 10

th, 2008. Invited Podium Presentation.

2007 J.L. Min, J.M. Taylor, T. Watts, K.R. Ahmadi, J.B. Richards, J. Broxholme, F. Pettersson1, I.

Ragoussis, T.D. Spector, K.T. Zondervan, L.R. Cardon. The use of genome-wide eQTL associations to identify novel genetic pathways involved in complex traits. American Society of Human Genetics 57

th Annual Meeting, San Diego, California, October 26, 2007. POSTER.

JB Richards, AM Valdes, JP Gardner, M Kimura, X Lu, R Swaminathan, A Aviv, TD Spector. Higher Serum Vitamin D Levels are Associated with Increased Leukocyte Telomere Length in Women.Endocrine Society, Toronto, ON, June 4

th, 2007. Podium Presentation, Winner of

top-ranked abstract travel grant.

JB Richards, AM Valdes, K Burling, UC Perks, TD Spector. Serum Adiponectin and Bone Mineral Density in Women. European Congress for Clinical and Economic Aspects of Osteoporosis, Porto, Portugal, March 31

st, 2007. Podium Presentation, Winner of top-ranked

abstract award for a researcher under the age of 40.

2006 JB Richards, A Papaioannou, JD Adachi, L Joseph, HE Whitson, JC Prior, D Goltzman, “The Impact of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture”. International Osteoporosis Foundation, Toronto, ON, June 6

th, 2006. Osteoporosis International 18: S1.

Podium Presentation.

JB Richards, WD Leslie, L Joseph, et al. “The Impact of Fracture Risk Classification Systems on the Prevalence of Treatable Osteoporosis.” International Osteoporosis Foundation, Toronto, ON, June 5

th, 2006. Osteoporosis International 17:2, S24 2006. POSTER.

JB Richards, A Papaioannou, JD Adachi, L Joseph, HE Whitson, JC Prior, D Goltzman. “The Impact of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture.” Endocrine Division Annual Retreat, McGill University, May 2006. PODIUM PRESENTATION

2005 JB Richards, L Joseph, K Schwartzman, N Kreiger, A Tenenhouse, D Goltzman. “The Effect of Cyclooxygenase-2 Inhibitors on Bone Mineral Density: Results from the Canadian Multi-Centre Osteoporosis Study.” American Society for Bone and Mineral Research, Nashville, TN, September 25

th, 2005. PODIUM PRESENTATION

2004 JB Richards, G Keyhan, L Vautour. “Asymptomatic Pheochromocytoma Presenting with

Reversible Eosinophilia: A Novel Association” Presented to The Endocrine Society International Congress, on June 16

th, 2004, in New Orleans, Louisiana.

JB Richards, R Kozak, P Brassard, D Menzies, K Schwartzman. “Tuberculosis Surveillance Among New Immigrants in Montreal” Presented to the “10

eColloque provincial en maladies

infectieuses”, May 6th, 2004, Quebec City.

2003 JB Richards, R Kozak, P Brassard, D Menzies, K Schwartzman. “Tuberculosis Surveillance

Among New Immigrants in Montreal.”American Thoracic Society International Congress, May 20

th, 2003, Seattle, Washington. POSTER.

1998 JB Richards, MA Lee.“Prevalence of Psychiatric Manifestations in Post-Operative Temporal

Lobectomy Epileptic Patients” Presented to the Canadian Congress of Neurological Sciences, Vol. 5 Sup 2, S61 May 1998.

Non-Peer Reviewed Articles 2008 JB Richards, Genome-Wide Association Studies and Osteoporosis: What do I need to know?

Osteoporosis Update. Fall 2008.

BOOK CHAPTERS

2009 Ian R Reid and JB Richards, Adipokine Effects on Bone, In: Clinical Reviews in Bone and

Mineral Metabolism. Springer 2009 In Press

INVITED PRESENTATIONS

CQDM Mentor Meeting, GSK and Pfizer, May 23 2012. Somatic Mutations in Inflamed Joints.

Montréal.

Genomics of Osteoporosis: Advances and Challenges. Hong Kong University, China, May 4th

2012. Hong Kong University,-McGill Symposium.

Identifying Drug Targets through Genomics, Canadian MultiCentre Osteoporosis Annual Meeting, Delta Centre-Ville, April 28

th, 2012

Drug Repositioning through Genomics, PharmaScience, Montréal, QC, April 27, 2012

Somatic Mutations in Auto-Immune Disease, McGill University Health Centre Rheumatology Grand Rounds, April 27, 2012

Genetic epidemiology of aging-related disease, McGill University and Genome Quebec Innovation Centre, Annual Research Day, January 27, 2012

Somatic Mutations and CQDM. CQDM grant program description. CQDM at the MUHC, MGH Site, January 18, 2012

Can we find Osteoporosis Drugs Through Genetics?. McGill MUHC Endocrine Division Grand Rounds. Montréal General Hospital, December 1, 2011

Can Genetics Identify Drug Targets? McGill Bone Symposium. Faculty Club October 28th, 2011

Anabolic Genotypes for Anabolic Drugs. Lilly Pharmaceuticals Inc. Indianapolis, By teleconference. Bone Biology Drug Development Group. October 28

th, 2011

Somatic Mutations in Rheumatoid Arthritis. Jewish General Hospital, Rheumatology Rounds, October 18, 2011.

Genomics of Osteoporosis. McGill Department of Medicine, Annual Research Day, May 27, 2011

The Genomics of Common Disease. Lady Davis Institute, Annual Research Retreat, May 20, 2011

The Genetics of Insulin Resistance. Jewish General Hospital, Division of Endocrinology Grand Rounds. January 13, 2011

Insights from Genetic Epidemiology. McGill University Health Centre Department of Epidemiology. October 14, 2010

Genetics of Complex Aging-Related Disease: Common Variants and Beyond. Canadian Genetic Epidemiology and Statistical Genetics Meeting. Kingsbridge. April 15, 2010

The Allelic Architectures of Common Disease. Annual Canadian Human Genetics Conference, Mt. St. Sauveur. April 20, 2010

The role of rare variants in common disease. King’s College London, May 23, 2009

Genetics of Aging-Related Disease. McGill University, Department of Anatomy and Cell Biology, May 13 2009.

Could Glucose Still be Causing Macrovascular Disease in Type 2 Diabetes? Presented to the Division of Endocrinology, Jewish General Hospital, Feb 12, 2009.

Genetics of Complex Disease...Complex Indeed. Presented to the Division of Epidemiology and Biostatistics, Jewish General Hospital, Sep 17, 2008. Department of Endocrinology, McGill University, Sep 25, 2008. Division of Endocrinology, Jewish General Hospital, Sep 11, 2008. Department of Epidemiology, McGill University November 24, 2008. Department of Human Genetics, McGill University January 8, 2009

New Insights into the Genetics of Complex Disease. Presented to the McGill University Bone Club, December 8

th, 2008. Department of Human Genetics, November 20, 2008. Division of

Epidemiology McGill University Health Centre November 6th, 2008

Genetics of Osteoporosis in the TwinsUK cohort. Genetic Factors For Osteoporosis EU Consortium General Meeting, Erasmus MC, Rotterdam, the Netherlands, March 7

th, 2008

Telomere Length: Genetic and Environmental determinants of a Biologic Clock. University of Toronto, June 2007

Telomere Length: Genetic and Environmental determinants of a Biologic Clock. University of Montreal, June 2007

Telomere Length: Genetic and Environmental determinants of a Biologic Clock. University of Calgary, June 2007

Telomere Length: Genetic and Environmental determinants of a Biologic Clock. University of Ottawa, June 2007

Candidate Longevity Genes and Telomere Length: A Genetic Association Study. Invited Presentation to the National Institutes of Health Longevity Consortium, Santa Fe New Mexico March 17, 2007

Montreal Bone Club, February 22nd

2007. “Sad to the Bone: The Relationship Between SSRIs and Osteoporotic Fractures.”

Endocrine Combined Grand Rounds, January 19th, 2006. “More Surprises from COX-2 Inhibitors: The effect of COX-2 Inhibition on Bone Mineral Density.”

Montreal General Hospital Clinical Epidemiology Seminars, October 25th, 2005. “Do COX-2 Inhibitors alter Bone Metabolism?”

Jewish General Hospital, Endocrine Grand Rounds, September 15th, 2005. “Is Osteoporosis an Inflammatory Disease?”

University of Ottawa, Endocrinology Grand Rounds, January 11th, 2005. “The effects of COX-2 Inhibition on Bone Mass.”

Endocrine Combined Grand Rounds, November 25th, 2004. “Osteoporosis and Aortic Calcification; Calcium Unbalanced.” McGill University

Endocrine Grand Rounds, December 4th, 2004. “Bilateral Macronodular Adrenal Hyperplasia” McGill University

McGill Internal Medicine Residents’ Research Symposium May 14th, 2003. “Effectiveness of the Montreal TB Screening Program for New Immigrants.”

Clinical Pathological Correlations Grand Rounds November 5th, 2001. “A Case of Acute Renal Failure and Shortness of Breath” McGill University

McGill University Medical Student Seminars. November 11th, 2003. “Diabetic Ketoacidosis and Non-Ketotic Hyperosmolar State”.

McGill University Medical Student Seminars. April 14th, 2004. “An Approach to Thyroid Nodules.”