10 Things You Need To Know About Hemp-Derived CBD

Presented by: Aimée Shunney, ND

10 Things You Need To Know About Hemp-Derived CBD

1.Semantics2.History3.Balance is

Everything4.Utility5.Grow Practices

6.Source7.Whole Plant

Synergy8.Research9.Safety10.Legal Questions

1. Know Your Definitions

Cannabis Sativa, Agricultural Hemp, Medical Cannabis,

CBD & THC

Words Matter•Cannabis Sativa L.

– Source of medical cannabis and agricultural hemp– Contains 60-100 constituents– THC: psychoactive– CBD: not-psychotoxic

•Medical Cannabis (MC) - cannabis for medical purposes

– Marijuana (MJ) - cannabis for recreational purposes•Agricultural Hemp (AH) – until recently referred to the commercial use of the cannabis stalk and seed

– less than 0.3% THC by dry weight

2. History of Cannabis Use & Safety

History of Cannabis

• First reported as medicine > 5000 years• Introduced into Western medicine in

1840s by Dr. W.B. O’Shaughnessy• Cannabis extract from cannabis plants

was the medicine of choice in the early 1930s

• Promoted as analgesic, sedative, anti-inflammatory, antispasmotic, and anticonvulsant properties

• Available in 1906 Mfg by Eli Lilly, Wyeth Park-Davis, Sharp & Dohme

3. The EndocannabinoidSystem (ECS)

Balance is Everything

Master Control System (ECS)•Endocannabinoids are “messengers”, isolated from brain and peripheral tissues that communicate via cannabinoid receptors

–Anandamide and 2AG–Main Receptors: CB1 and CB2

• Involved in the direct regulation of appetite, metabolic health, pain/inflammation, thermoregulation, intra-ocular pressure, sensation, muscle control, motivation/reward, mood, and memory

• Involved in learning and synaptic plasticity

Balance is Everything•ECS tone requires CB1 and CB2 balance as well as ‘optimal’ CB1 activation

•Optimal CB1 activity decreases anxiety, reduces pain, decreases inflammation, controls sensory perception, memory and cognitive function

•Anandamide binds to CB1 as does THC which can over stimulate CB1

–Stress will increase Anandamide–Anandamide derived from Omega6

•Overstimulation of CB1 has many negative effects

WHY SHOULD WE CARE ABOUT ECS TONE?

Source: http://eurheartjsupp.oxfordjournals.org/content/10/suppl_B/B34/F1.expansion

Master Control System (ECS)

“…Science has linked the ECS with

complex processes from anxiety to

immunity…This research bonanza is

revealing more and more about the ECS

master control system and it’s shining

star, cannabidiol.”

4. Potential Uses of CBD

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5. Environmental and Health Impact of Grow Practices

Agricultural Hemp vsMedical Cannabis

Comparing Hemp to Medical CannabisIndoor Grown Medical Cannabis

• Enormous Carbon Foot Print• Environmentally Harmful• Wasteful Water Demands • Huge Strain on Power Grid• Consequences of Fungicides, Pesticides

and Fertilizers• Unsustainable

Outdoor Grown Agricultural Hemp• Sequesters CO2• Environmentally Helpful• Requires 80% less water• Sun Powered Outdoor Grow

– No artificial light Sources required

• Zero Fungicides, Pesticides and Fertilizers • Textbook Sustainability

December 3, 2015

2014

6. Does Source of CBD Matter?

NO! Source Does Not Matter

• CBD is CBD • CBD from AH or high-CBD strain MC act the same in our bodies

• CBD from AH affords a non-psychoactive option

And…Agricultural Hemp is Amazing!• Non-psychotoxic

–Supports health and balance without a ‘high’• Whole Plant Incredibly Useful

–Food, fiber, building materials, fuels – 25K uses!• Nutrient-rich

– EFAs, amino acids, vitamin E, phosphorus, potassium, sodium, magnesium, sulfur, calcium, iron, zinc

• Eco-friendly– Sequesters CO2 – No herbicides– Repletes soil

7. The Entourage Effect

Whole Plant Synergy

•Entourage Effect – refers to the idea that different constituents of cannabis work synergistically

–Overstates the importance of THC–Ignores the benefits from all the other parts of the plant not used when only ingesting flowers

•Hemptourage Effect – refers to the idea that you get superior synergistic benefit from ingesting the over 500 components found in the whole plant

–Minimal THC

TOTAL PLANT COMPLEX – GREEN FORMULA

GOLD FORMULA

8. State of the Research

Why Don’t We Have More Research?

• Cannabis is listed as a Schedule 1 drug, making it difficult to conduct research over certain limits• CBD is not directly scheduled, there is no reference of CBD in

the Federal Acts• AH not a controlled substance

• Only allowed to be grown under research oversight and illegal to commercially grow and extract in US

• Good source material for phytocannabinoids is difficult to obtain.• Issues with growing, selling, and transporting across state

lines.• Can be imported

9. Safety Data

CBD’s Remarkable Safety Profile

•Studies showing CBD as non-toxic–Does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature)

– Does not affect gastrointestinal transit nor alter psychomotor or psychological functions.

– Chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.

•Conclusion: Based on recent advances in cannabinoidadministration in humans, CBD shows safety in humans and animals

10. State of Legal Issues

Remember:• Hemp is not defined as “marijuana” under the Controlled

Substances Act (CSA) • Expressly and intentionally excludes: mature stalks, fiber from stalks,

oil or cake made from seeds, any other compound, manufacture, salt, derivative, mixture, or preparation of such mature stalks (except resin extracted therefrom), fiber, oil, or cake, or the sterilized seed of such plant which is incapable of germination.

• Naturally occurring cannabinoids in agricultural hemp foods, including oils, were never scheduled under the CSA.

• Agricultural hemp fiber, stalk, seed, and oils can be lawfully imported into the United States and these portions of the hemp plant may enter into US commerce

In order to make the highest quality CBD products, we believe it is imperative to be a part of every step of the supply chain process.

FULL TRACEABILITYFROM SEED TO SHELF™

THE DIFFERENCEBETWEEN OUR OILS

The raw oil is a total plant CO2 extract from agricultural hemp, imported from Europe. Cannabidiolic Acid, or CBDA, comprises a significant proportion of the extracted cannabinoids in the raw oil. CBDA is an acidic cannabinoid, the naturally-occurring raw form of CBD that is produced directly in the plant, and contains many beneficial properties distinct from CBD.

RAW

DECARBOXYLATION

DISTILLED

TOTAL PLANT COMPLEX

GOLD FORMULAOur Gold Formula is the ultimate step in refining our oil, where excess plant material is distilled from our decarboxylated oil in a solvent-free process, rendering the oil gold in color. The final oil comprises only of CBD, minor cannabinoids, and plant-derived fatty acids. Our Gold Formula oil is the highest-concentrated form of CBD oil that we offer.

The raw oil undergoes a process called decarboxylation (a gentle heating process), in which most of the remaining CBDA is converted into CBD to maximize the concentration of CBD.For example, if the raw oil consisted of 100 milligrams of CBDA and 100 milligrams of CBD, the decarb oil will contain a sum of 200 milligrams of CBD after decarboxylation, along with many of the cannabinoids, terpenes, plant sterols, vitamin E and other natural plant material that comprises our Total Plant Complex.

TOTAL PLANT COMPLEX

GOLD FORMULA

PlusCBD Oil™Balm

2-10 sprays = 1mg-5mg CBD

PlusCBD Oil™1oz 100mg Spray

Unflavored

Peppermint

Vanilla

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Natural Vanilla Flavor, Stevia Leaf Extract, Potassium Sorbate

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Peppermint Oil (MenthaPiperita), Stevia Leaf Extract, Potassium Sorbate

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Stevia Leaf Extract, Potassium Sorbate

PlusCBD Oil™2oz 200mg Spray2-10 sprays = 1mg-5mg CBD

Unflavored

Peppermint

Vanilla Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Natural Vanilla Flavor, Stevia Leaf Extract, Potassium Sorbate

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Peppermint Oil (MenthaPiperita), Stevia Leaf Extract, Potassium Sorbate

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Stevia Leaf Extract, Potassium Sorbate

2-10 sprays = 3mg-15mg CBD

PlusCBD Oil™2oz 500mg Spray

Unflavored

Peppermint

Vanilla

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Natural Vanilla Flavor, Stevia Leaf Extract, Potassium Sorbate

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Peppermint Oil (Mentha Piperita), Stevia Leaf Extract, Potassium Sorbate

Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Stevia Leaf Extract, Potassium Sorbate

Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed.

PlusCBD Oil™1g Green Applicator

Other Ingredients: none

Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed.

PlusCBD Oil™1g Gold Applicator

Other Ingredients: none

Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed.

PlusCBD Oil™3 & 10g Green Applicator

Other Ingredients: none

Other Ingredients: none

Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed.

PlusCBD Oil™3 & 10g Gold Applicators

Other Ingredients: none

Other Ingredients: none

PlusCBD Oil™30ct Capsules

Other Ingredients: Food Starch - modified, Vegetable Cellulose, Silicon Dioxide, Vegetarian Capsule (Vegetable Cellulose, Water)

Use: 1 capsule daily.

PlusCBD Oil™1gm Grams

Other Ingredients:None

SUGGESTED USE: Take 1 serving daily. Scoop 250 mg (1/4 container). Place in mouth and swallow.

TOTAL PLANT COMPLEX– FOR THE PURIST

PlusCBD Oil™1gm Grams

Other Ingredients:None

SUGGESTED USE: Take 1 serving daily. Scoop 250 mg (1/4 container). Place in mouth and swallow.

GOLD FORMULA– FOR MAXIMUM EFFECT

PROUD MEMBERS OF:

American Herbal Products Association

Hemp Industries Association

Kentucky Hemp Industries Association

Kentucky Hemp Industry Council

European Industrial Hemp Association

National Hemp Association

TakeawaysWhat to Look For In a CBD Company/Product?

–Full Traceability–No medical claims or dosing recommendations

–Efforts to grow research–GRAS self-determination/safety assessments

–Commitment to Education–Involvement with Trade Organizations

Thank you for attending our teleseminar!

QUESTIONS?