PMC Spring 2016 Meeting Knowledge Management

March 10, 2016

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Insufficient knowledge capture - Explicit knowledge - Tacit knowledge

Past “KM” failures - KM = IT - Lack of processes,

culture, sponsorship

Growing network, complexity

- Globalization - Externalization - In- & Out-licensing - Market pressures - M&A Increased Expectations

& Opportunity - ICH Q10 - Regulatory bodies

With Growing Pressures… the need for knowledge flow came in to focus

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The Business Challenge Leveraging Content Analytics to Accelerate Change

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The MMD Knowledge Ecosystem

Expertise Connectivity

Processes Products

Knowledge & Learning Transfer

Explicit documented to read & review

Tacit held by people, who interpret &

extrapolate

Retention of Critical Knowledge (ROCK)

Product Technical Knowledge

After Action Review

Technology Platform

Virtual Technical Network (VTN)

A Practical Approach to Managing Knowledge, a Case Study of the Evolution of KM at Merck --ISPE (Nov/Dec 2013)

For more information…

PRODUCT KNOWLEDGE Taxonomy and stewardship enhancing collaboration and

teamwork across sites

‘Accelerated process development with less drama’

PROCESS KNOWLEDGE Global standards for expertise and

technology prevent supply disruption

‘One stop shop for platform

expertise’

CONNECTIVITY Global communities provide rapid, on-demand connectivity to solve

problems and share best practices

‘Timely global expertise to support clinical and commercial supply’

EXPERTISE Risk-based approach to capturing

the ‘what’ and the ‘why’ from tenured experts

‘Improving the outcome of sterility

investigations’

KNOWLEDGE & LEARNING TRANSFER Standard work and mindsets to pause and reflect

‘Driving meaningful continuous improvement through After Action Reviews’

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Improved Knowledge Flow = Improved KPI’s

Spend ↓

More informed, aligned and rapid regulatory response

Employee Engagement ↑

Product Supply ↑

Regulatory Compliance ↑

People Capability ↑

Right First Time ↑

Capability… Which Enables… Which Drives…

Faster knowledge transfer and application

Employees more engaged, empowered & connected

Reuse of captured knowledge across products & platforms

Connectivity & platform knowledge avoid disruptions

Standard work powered by collaboration and knowledge

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4. Take Committed Action

Continual improvement throughout our business … • Standard work for knowledge sharing • But now we see more…

– After Action Review • Take 5! • Take 60! • Take a Day! • ‘Diversity 5!’

– Proactive Process Analysis TAKE 5! WALLET CARD

PPA COMMUNITY

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“Did you consider…” “You should talk to…” “When that happened to us, we…” “Here is the link to…”

VTN Enables the POWER of the NETWORK

“Have you seen…?” “Does anyone know…?” “What else should we try…?” “How would you…?” “URGENT: HELP NEEDED…!”

The NETWORK

• 27 Communities • 4,000 members • >2000 questions,

>6000 responses (2013-14) • 40% ex-US membership • Countless new connections

established

• 50% hidden expertise • 81% increased engagement • No need to go “up and over” • 2014 winner: MLC’s

Workplace Leadership • Much benefit from improved

connectivity & collaboration (safety, quality, supply, …)

The IMPACT

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$3MM and 20 weeks saved when our global network leveraged Tier Process, VTN and Compression Technology Platform to ensure reliable, cost-effective Supply of a Key Product

What this looks like in action: Success Story

GTO, GPC, CMSE, GES West Point

GTO Netherlands

GES Singapore

GTO UK

Ops Ireland

Hazem

Mark

Jon

Olav

Michael

Patrick

Gordon Joseph

Our global network engaged rapidly to locate a spare turret in Singapore within 1 business day to replace a damaged turret used for a Key Product in the UK Operational in 4 weeks versus 24 weeks for new turret from vendor Avoided possible stock out of an important medicine in certain markets

External Partner

Roger

Tablet press turret

GTO Ext Manf

Tablet press machine

“The VTN makes you feel like you’re part

of something larger” - Roger – GTO Ext Manf

HEPA Filter Investigation ‘PRODUCT X’ Supply A VTN SUCCESS STORY

The Scenario: • On Aug 27th, VTN

Member posts a query looking for information on investigating failure of a clean-room ceiling HEPA filter.

• Investigation impacted PRODUCT X launch materials

Impact:

• PRODUCT X program was able to rapidly close the investigation and release launch materials.

• Launch of a life saving therapy would have otherwise been at risk!

How the Community Helped:

• In less than 24 hours directly relevant replies with examples of similar investigations

VTN is FAR REACHING

and INCLUSIVE 3 Countries

+4 Global Organizations

4 Plant Sites

Made a New Connection Made a Contribution Gave/Got Energy Back Helped a Colleague Solved an Issue Gained New Knowledge

Member Discussions

• Communities, Best Practices • E-room globally connected