polyphenolics 2013
TRANSCRIPT
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Dr. M. [email protected]
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To cover the nutraceuticalusefulness of polyphenols
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naturally occurring compounds
mainly ANTIOXIDANTS
found largely in the fruits & vegetables
e.g. grapes, apples, pears, cherries and various berriescontains up to 200-300 mg /100 grams fresh weight.
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100 mg polyphenols =
cup of tea or coffeeglass of red wine
http://rds.yahoo.com/_ylt=A0PDoTGj8JJNMS8A06GjzbkF/SIG=12uk59qgf/EXP=1301504291/**http%3a//upload.wikimedia.org/wikipedia/commons/1/1f/Brown_cup_of_coffee.jpghttp://rds.yahoo.com/_ylt=A0PDoX1I8JJN9ToAsjWjzbkF/SIG=130kv6js5/EXP=1301504200/**http%3a//www.scenicreflections.com/files/Glass_of_Red_Wine_Wallpaper_taa51.jpg -
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1.Phenolic acidsGallic acid
Caffeic acid
Source
Blueberries, oilseed,apricots
2. StilbenesResveratrol
Sources
Grapes, Peanuts,
Pomegranate
3. LignansExamples
Secoisolariciresinol
Sources
Flax seed,
Pumpkin seeds,
Sesame seed
4. Flavonoids
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Flavonols
Flavanones
Flavanols Flavones
Anthocyanins
Isoflavones
FLAVONOIDS
Quercetin
Kaempferol
Myricetin
proanthocyanidins
NaringeninHesperetin Epicatechin
Catechin
Gallocatechin
Apigenin
Luteolin
Cyanidin
Delphinidin
Malvidin
Daidzein, Genistein
Sources: Apples, Grapes, Onions, Soya beans, Cranberries
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Phytoestrogens = Oestrogenic-like qualities(phytoestrogen) :1000 x LESS
LIMITED EVIDENCE
reduce menopausal symptoms
prevention of bone resorption
(osteoporosis) in post-menopausal
women
Reduce LDL and increase HDL
http://ods.od.nih.gov/News/The_Scoop_-_October_2011.aspx#6
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Genistein supplements
Sold in 1000 mg supplements
Recommended for menopausal
women
1 -2 capsules per day
Soya Vaginal Gel.
Contains soyabean extract with 10%
isoflavone
Use for vaginal dryness associated with
menopause.
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Contain mainly epicatechins
CV benefits- decrease systolic BP
Capsules and tablets = 50 to 100 mg per day ofextract
Dose: 1 capsule /day of a 100mg preparation
Contains cathechin
Decreases TC and LDL
Major component of Green tea extract
Dose: Not yet standardize
250-300 mg daily
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CONTAINS Proanthocyanidins
UsesAntioxidant , Prevent UTIs
Proanthocyandins of cranberry prevent E. coliadhesion to urinary tract
More research required
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Good scientific evidence-more studies needed
Suggest more useful for recurrent UTIs
reduces adherence of bacteria to cells lining thebladder thereby reducing UTI
800-900 mg daily-oral
Cochrane Database Syst Rev. 2008 Jan 23;(1):CD001321
Possible stone formation dueto oxalate composition canoccur with excessiveconsumption.
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Main component= Secoisolareciresinol
Phytoestrogens
Shown to reduce plasma cholesterol and
reduce arthrosclerosis
Flax seed- purported usefulness in
menopause, including reduce risk of breast
cancer
More research required
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PRESCRIBED TEXT
1. Dietary Supplements Pamela Mason
WEBSITES
1. Medline Plus
2. National Centre for Complementary &Alternative Medicine
3. Office of Dietary Supplements