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POSITIONS OPEN

ASSISTANT/ASSOCIATE PROFESSOR

Neurodegenerative DisordersDepartment of Pharmacology

College of PharmacyThe University of Toledo

The Department of Pharmacology, College of Phar-macy, at the University of Toledo is inviting applica-tions for a tenure-track position in neurodegenerativedisorders available at the Assistant/Associate Professorlevel. Requirements include the Ph.D. in pharma-cology, pharmaceutical sciences, or a related field andproductive postdoctoral experience. Candidates withexperience in the area of experimental therapeuticsare encouraged to apply. Responsibilities for the po-sition will include teaching undergraduate and grad-uate level courses in pharmacology or related areas.Current areas of research considered to be prioritiesfor the health sciences at the University of Toledoinclude: neurodegenerative diseases, cancer, organtransplantation/immunology, cardiovascular/diabetes,and orthopedics. The successful candidate will be ex-pected to develop and maintain an active, externallyfunded research program that complements existingresearch strengths within the Department, as well asthe colleges of pharmacy and medicine. A competitivesalary and research startup package will be provided.Interested individuals are encouraged to submit cur-

riculum vitae and a letter describing teaching philoso-phies and research goals and to arrange for three lettersof reference to be sent to: Ezdihar Hassoun, Ph.D.,Chair of the Search Committee (PCN 995036),Department of Pharmacology, #607, The Uni-versity of Toledo, College of Pharmacy, 2801 W.Bancroft Street, Toledo, OH 43606. E-mail: [email protected]. Applicant review process willbegin on April 1, 2009, and will continue until theposition is filled.

The University of Toledo is an Equal Access, Equal Oppor-tunity, Affirmative Action Employer and Educator. Women andminorities are encouraged to apply.

RESEARCH ASSOCIATE/POSTDOCTORAL FELLOW

The University of Arkansas at Little Rock seeksapplicants to fill a position of Research Associate/Postdoctoral Fellow (requisition #661), working withDr. Hong Li Wang to study transfer cell developmentin economically important crops in the research areasof molecular biology/gene regulation, functional ge-nomics and bioinformatics, and cell structures to startas soon as possible.The position is funded by a National Science Foun-

dation Experimental Program to Stimulate Competi-tive Research grant. The research is aimed to revealthe molecular mechanism(s), genes, and regulatorypathways(s) involved in transfer cell development.Applicants should hold a Ph.D. in molecular biol-ogy, cell biology, or botany. Preference will be givento candidates with experience in cell structure studyusing light, fluorescent, and laser confocal micros-copy, gene expression profiling, gene functionalanalysis using in situ hybridization or direct visual-ization of subcellular location by fluorescent pro-teins, knockout gene expression using gene silencingand/or mutation.To apply: submit a letter of application (referencing

requisition #661), curriculum vitae, a brief descrip-tion of career goals, and three professional referencesto: Dr. Keith Hudson, Director, Graduate Instituteof Technology, 2801 S. University Avenue, LittleRock, AR 72204. Direct all technical inquiries to:e-mail: [email protected]. Electronic submissions arepreferred; e-mail: [email protected] with requisi-tion #661 in the subject line or fax: 501-569-8039 ortelephone: 501-569-8210. Related website: http://www.ualr.edu/biology/.

UALR is subject to Equal Employment Opportunity/Affir-mative Action/Freedom of Information laws. Persons hired mustprovide proof of legal authority to work in the United States.

POSITIONS OPEN

FACULTY POSITIONSIN PHARMACOLOGY

Texas Tech University Health Sciences CenterSchool of Pharmacy

Applications are invited for several tenure-track facultypositions at the ASSISTANT/ASSOCIATE/FULLPROFESSOR rank in the Department of Pharmaceu-tical Sciences. We are seeking colleagues with researchinterests complementary to those of present facultywho are active in research on novel drug targets anddrug delivery methods for vascular and inflammatorydiseases. Current projects include drug targeting tovascular endothelium at the blood-brain barrier,ischemia-reperfusion injury of brain and liver, and de-velopment of antihypertensive drugs. A Center for Vas-cular Drug Research has recently been formed at theSchool of Pharmacy to serve as a nucleus for facultycollaboration. The Department comprises 22 full-timefaculty with about 40 graduate students. Growth overthe next four years is expected to take the Departmentto 30 faculty. A new 48,000 sq. ft. research facility hasjust been completed to supplement the greater than100,000 sq. ft. main facility adjacent to the Amarillocampus of the TTUHSC School of Medicine. Amarillois a town of about 200,000 on the high plains ofTexas with excellent opportunities for cultural activ-ities, family life, and outdoor sports. For further infor-mation, visit our websites: http://www.ttuhsc.edu/sop/PharmSci/ and http://www.ttuhsc.edu/sop/research/internalgrants/.../default.aspx.Applicants must have an earned doctoral degree in

pharmacology, pharmaceutical sciences, or related dis-ciplines with relevant postdoctoral experience. Activefunding is required for consideration at the rank ofAssociate or Full Professor. In addition to maintainingan extramurally funded research program, the successfulcandidate will teach and mentor students in the pro-fessional (Pharm.D.) and graduate (Ph.D./M.S.) pro-grams of the University. Competitive startup packages,incentives, and laboratory space are available. Pleasesubmit curriculum vitae, a summary of research andteaching interests, desired rank, and names and ad-dresses of three references online at website: http://jobs.texastech.edu (job requisition # 78518). Applica-tions will be accepted until the positions are filled.However, those received by April 15, 2009, are as-sured of full consideration. For questions, contactthe search committee chair:Ulrich Bickel, M.D., TexasTech University School of Pharmacy, 1300 Coulter,Amarillo, TX 79106. E-mail: [email protected]; fax: 806-356-4034. TTUHSC is an Equal Oppor-tunity/Affirmative Action Institution. Minorities and women areencouraged to apply.

RESEARCH FACILITY MANAGER

Fox Chase Cancer Center, located in Philadelphia,Pennsylvania, is seeking a Research Facility Manager.Requires Ph.D. or M.D. and experience in G-

banding, fluorescence in situ hybridization, and Af-fymetrix GeneChip/Agilent microarray analysis. Work-ing knowledge of PERL language, SAS programming,and common bioinformatics tools (e.g., R and Biocon-ductor, Ingenuity pathway analysis, Partek, and so on)highly desirable. Salary commensurate with experience.For full consideration, applications (including a letterof interest, curriculum vitae, and e-mail address) shouldbe sent by April 1, 2009, to: e-mail: [email protected]. Equal Opportunity Employer.

POSTDOCTORAL FELLOW POSITIONSavailable to study the molecular mechanisms under-lying leukocyte trafficking through three-dimensionalextracellular matrix barriers in vitro and in vivo (e.g.,Trends in Cell Biol. 18:560, 2008). Strong back-ground in cell/molecular biology and/or intravitalmicroscopy will be required. Send curriculum vitaeand letters of reference to: Stephen J. Weiss, M.D.,Upjohn Professor of Medicine, Life SciencesInstitute, University of Michigan, 5000 LSI, 210Washtenaw, Ann Arbor, MI 48109-0640. The Uni-versity of Michigan is an Equal Opportunity Employer.

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13 MARCH 2009 VOL 323 SCIENCE www.sciencecareers.org1508

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In the current economic climate, the pharmaceutical industry may not seem like the likeliestplace to forgeacareer, particularly in lightof the recent spateof layoffs.While today’seconomicconditions are brutal, the forces shaping the drug industry’s downsizing and restructuringhave been at play for some time. By Virginia Gewin

Out of the carnage come opportunities. Recent high profile drug failures—notablythe withdrawals of the painkiller Vioxx and diabetes drug Avandia—have shedlight once again on drug safety. As well, pharmaceutical companies are lookingfor new ways to address their two-pronged pipeline problem: many big-nameblockbuster drugs will soon lose their patents and, perhaps more important,

there is a dearth of new blockbusters headed to the market. In fact, over 90 percent of allcandidate compounds that are developed never reach the market (Beresford AP, et al. DrugDiscov Today 7(2):109–116, 2002).Drug discovery and development has historically been a trial-and-error approach whereby

companies screen thousands to millions of compounds. But regulatory bodies and a growingnumber of drug discovery companies want more predictive scientific approaches in place tolower the chance of failure in clinical trials. “The biggest resource demand in toxicology istime because many studies, such as carcinogenicity assays, require years to complete,” saysDavid Jacobson-Kram, associate director for pharmacology and toxicology at the US Food andDrug Administration’s Center for Drug Evaluation and Research in Silver Spring, Maryland.Therefore, FDA is encouraging industry to use existing knowledge to do earlier stagesimulations of the absorption, metabolism, and excretion of drug candidates. The search ison for new drug safety metrics, and the “virtual” trial may not be far behind.As a result, an interesting mix of quantitative skills is in demand. Toxicology, the

traditional tests for adverse drug effects, continues to drive early drug discovery efforts. Butpharmacometrics—the modeling and statistical analysis of drug metabolism data—touts amore tailored, predictive approach to safety and efficacy. In simple terms, pharmacokinetics,PK, measures what the body does to the drug, while pharmacodynamics, PD, measures whatthe drug does to the body. Therefore, the simulation and modeling of PK/PD using in vitrodata from human and animal models is becoming a more important means to better weed outpotentially harmful drugs sooner in preclinical drug development. As such, their adoption inindustry is gaining traction, and providing career opportunities.“Pharmacometric analysis is key to understanding the relationship between exposure and

response, and this critical knowledge will help companies avoid late-stage failures,” says JillFiedler-Kelly, vice president of pharmacometric services and chief scientific officer of Buffalo,New York–based Cognigen Corporation, a contract research organization (CRO). In fact, shesays, recruiters are actively looking for persons with pharmacometric skills, a group thatseems fairly immune to the ongoing layoffs.

Promising Prospects“The safety science space has been using the same models for 25 years, making the fieldripe for innovation,” says Joseph DeGeorge, worldwide head of safety assessment at Merck& Co, in West Point, Pennsylvania. Innovation includes developing metrics able to predictoutcomes. Prediction requires robust models that can simulate biological systems. Predictiveapproaches to pharmacodynamics and pharmacokinetics in humans using nonclinical datasets, and developing safety biomarkers, are two areas ready for big scientific advances, saysJacobson-Kram.DeGeorge says people who can cross disciplines are making the scientific breakthroughs.

“It isn’t good enough to be trained in pharmacokinetics or pharmacodynamics or geneexpression,” says DeGeorge. For example, he says, Merck recently combined traditionaltoxicology endpoints, genomics, and accessible protein biomarkers measured in

UPCOMING FEATURES

Careers in Green Science — April 3

The Road to Diversity in Science:Are We There Yet? — April 24

Careers in Biotech and Pharma—May 8

FOCUS ONCAREERS

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continued »

AAAS/Science Business Office Feature

SAFETY FIRST!CAREER IN DRUG SAFETYAND TOXICOLOGY

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“Pharmacometric analysis

is key to understanding

the relationship between

exposure and response, and

this critical knowledge will

help companies avoid

late-stage failures.”

CAREERS IN DRUG SAFETY/TOXICOLOGY

Jill Fiedler-Kelly

Phase 0, or virtual, trial is different,” says Amin Rostami-Hodjegan,pharmacologist at the University of Sheffield in the UK.

Low Supply, High DemandBoth the classical animal toxicology skills and futuristic pharmaco-metric skills are in huge demand but short supply. Indeed, industryprofessionals agree that the dearth of persons with doctorates inveterinary medicine (D.V.M.) degrees is a stumbling block to theirability to develop new methods. “D.V.M. pathologists are hard to re-cruit,” says DeGeorge. Johan Gabrielsson, senior principal scientistat AstraZeneca in Mölndal, Sweden, agrees and says the ongoingshortage of trained people in the field of quantitative pharmacologyand in vivo animal experimentation is in part the result of politicalpressure in the 1980s and ’90s to replace, refine, or reduce the useof animal studies. “Unfortunately, the ‘omics’ sciences do not yet of-fer a complete solution. We have to rely on in vivo data when we gofrom animals to humans,” says Gabrielsson. Seeing the continueddemand, a coalition of the Society of Toxicological Pathology (STP)and the American College of Veterinary Pathologists (ACVP) jointlyfund training opportunities.Training in pharmacometrics is equally hard to come by. “All big

pharma companies are searching for people with PK/PD skills, butthe demand is much greater than the actual output from academia,”says Gabrielsson.Meindert Danhof, head of the Leiden/AmsterdamCenter for Drug Research in the Netherlands, agrees. “Thebottleneck is the number of academic sites to learn these skills,”he says. Indeed, graduate schools in the United States offering PK/PD programs are few—fewer still in Europe. And most graduatesare lured into industry. “Few graduates stay in academia, whichperpetuates its limited capacity to fulfill the increasing

humans and animals to develop a new biomarker signature that wasqualified by the FDA in 2008 to indicate kidney toxicity.Many see the development of new drug safetymetrics as the field’s

future. Perhaps not surprisingly, that is because FDA is leading thecharge. Jacobson-Kram expects to sustain at least some level oflast year’s 30 percent increase in staffing as FDA bolsters its ownquantitative capacity.“The most interesting and exciting area in early drug safety is to

develop new systems for assessing toxicity,” says Jacobson-Kram.“We’regettingawayfrom‘dose’emandcount ’em’studiesandmovingtoward using computer models to predict toxicities, and in vitroassays to make predictions about organ toxicities—that’s the future.In the next five to 10 years, we’ll eliminate much of animal toxicologyand move on to smarter systems using computer algorithms andmodeling,” he says. Combining new and old techniques—forexample, fusing molecular biology skills, pharmacometrics, andclassical toxicology—to find new safety biomarkers and surrogateendpoints represents a new pharmacological frontier.While drug safety is an industrywide concern, the adoption and

development of new drug safety metrics varies widely within theindustry. Some companies are sticking with traditional toxicologicalapproaches, while others, like Novartis, are actively exploring newdirections. While Novartis is still recruiting traditional veterinarypathologists trained in toxicology, it is also looking for toxicologistswith a background in biochemistry, molecular biology, and modernbiology techniques who are interested in molecular-based riskassessment. “To better understand safety issues, we are makingeffortstoemploymoremoderninvestigational,molecularapproachesto safety assessment—and increase our safety testing work force byabout 10 percent,” says Phil Bentley, vice president and global headof preclinical safety at Novartis Institutes for BioMedical Research inNew York City.Other top pharmaceutical and biotechnology companies—

including Genentech, Amgen, Pfizer, and Merck—also have anongoing need for pharmacometric skills to optimize drug efficacyand minimize potential toxicities. Genentech in San Francisco,for example, currently needs people with bioanalytical skills, withspecific emphasis on biotransformation and drug transport, saysHolly Butler, senior staffing manager for research.Recruitment efforts, however, aren’t typically designed to grow

company size. Instead, companies are more focused on maintainingproductivity while keeping the cost of drug discovery anddevelopment down. But that leads to tough choices. For example,so-called Phase 0 trials—preclinical trials designed to gather PK/PD data from subtherapeutic doses given directly to humans—willbypass animal experiments in this earliest stage in order to betterunderstand andmodel the drug’s action in humans. This informationshould not only identify any potential problems earlier but alsohelp design more effective clinical trials. But, at this early stage, thebenefits of virtual trials remain to be proven. “Everybody’s idea of a continued »

American College of VeterinaryPathologistswww.acvp.org

Amgenwww.amgen.com

AstraZeneca Internationalwww.astrazeneca.com

Cambridge Universitywww.cam.ac.uk

Cognigen Corporationwww.cognigencorp.com

Genentechwww.gene.com

International Society forthe Study of Xenobioticswww.issx.org

Leiden/Amsterdam Centerfor Drug Researchwww.lacdr.nl

Merck & Co.www.merck.com

Novartis Institutes forBioMedical Researchnibr.novartis.com

Pfizerwww.pfizer.com

Society of Toxicological Pathologywww.toxpath.org

State University of New Yorkat Buffalowww.buffalo.edu

University of Gotëborgwww.gu.se/english

University of North Carolina,Chapel Hillwww.unc.edu

University of San Franciscowww.usfca.edu

University of Sheffieldwww.sheffield.ac.uk

US Food and Drug Administration’sCenter for Drug Evaluationand Researchwww.fda.gov/cder

FOCUS ONCAREERS AAAS/Science Business Office Feature


Featured Participants“The safety science space

has been using the same models

for 25 years, making the

field ripe for innovation.”

—Joseph DeGeorge

www.sciencecareers.org/businessfeatures1510

Faculty of EngineeringDepartment of Chemical Engineering and Earth Science and EngineeringQatar Carbonates and Carbon Storage Research Centre

Academic Staff, Research Fellowships, PhDStudentships and a Programme Manager Positionin Clean Fossil Fuels

Major long-term funding by Qatar Petroleum and Shell International through the recently established QatarCarbonates and Carbon Storage Research Centre (QCCSRC) is enabling Imperial College London toexpand significantly its research into Clean Fossil Fuels – aimed in particular at improving the energyefficiency of oil and gas recovery closely coupled with reducing greenhouse gas emissions throughadvanced carbon capture and storage technologies.

An experienced Programme Manager is sought to co-ordinate the research projects within QCCSRC, underthe direction of the Programme Director, Professor G C Maitland, FREng. The successful candidate will haveseveral years’ research project management experience in the industrial or academic sector, preferably witha background in oil and gas technology.

Applications are also invited for 3 Lectureships and up to 10 Research Fellowships/Associateships fromcandidates with a proven world-class research track record who wish to build major new research activitiesin this area. A background in one or more of the following would be especially beneficial:

• The physics, chemistry and engineering of fluid flow in porous media;

• Fluid thermophysical properties, especially in extreme conditions;

• Burial diagenesis, structure and characterisation of fractured carbonate oil and gas reservoirs;

• Mineral-fluid interactions and reactive flow, especially in carbonate-based systems;

• Process modelling especially in the context of carbon storage and/or oil and gas recovery;

• Enhanced oil recovery processes.

Appointments at a more senior level will be considered for candidates with appropriate experience.Fully-funded PhD studentships are also available to work in these areas.

Academic staff appointees will be expected to pursue their own research interests, to contribute to theteaching and administration in one or both Departments and to be active and take on an academicleadership role in the activities of the QCCSRC. Exciting opportunities exist for evaluation of engineeringapplications in a field environment. Significant funding for research staff, studentships and equipment will beavailable. Appointees will also have the opportunity to contribute to the multidisciplinary Energy Futures Laband the Grantham Institute for Climate Change and to work closely with scientists and engineers in Shelland Qatar Petroleum.

For PhD Studentships, applications from Qatari citizens and neighbouring areas are particularly encouraged,although the call is open to candidates of all nationalities. Applications for Research Fellowships will beconsidered from both candidates with recent doctorates (or equivalent) and more experienced researchershaving a PhD (or equivalent). PhD candidates should have, or expect to receive, a first or upper secondclass honours degree (or equivalent) in a relevant engineering, physical or earth science discipline. Allresearchers will work in multidisciplinary teams in the QCCSRC and have close contact with the EnergyFutures Lab and the Grantham Institute for Climate Change.

On-line applications can be made through the College’s employment website:http://www3.imperial.ac.uk/employment/howtoapply Further information on salaries, job descriptions andperson specifications is also available on the website. Please direct any enquiries about these positions toAnn Sewell by email to: [email protected] or, for PhD applications, to Susi Underwood by email to:[email protected]

Closing date for applications: Tuesday 31 March 2009.(There is no closing date for PhD applications).

Valuing diversity and committed to equal opportunity

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FOCUS ONCAREERS AAAS/Science Business Office Feature

www.sciencecareers.org/businessfeatures1512


demand for these skills,” says Danhof. Driven by the need for well-trained professionals, industry employees such as Gabrielsson andFiedler-Kelly, serve as instructors of university courses.Gabrielsson says the lack of quantitative pharmacology training

opportunities is hurting the industry. “We lack people able to design,carry out, and analyze in vivo experiments, and then build models toextrapolate data across species and into man,” he says. CROs playan increasingly important role in drug development—from routineclinical trial management to more specialized modeling and simula-tion work—and are also having trouble recruiting. Fiedler-Kelly saysCognigen needs both senior and junior level pharmacometricians,but finding people with five to six years of experience applying thesemethods to address real issues in the regulatory environment ismost difficult. “We need people who use these methods, and caninterpret and synthesize the results, to answer questions that comeup during regulatory review and to provide the necessary feedbackto FDA,” she says.Pharmaceutical company and CRO dollars fund many of the top

programs, and offer valuable internship opportunities for students.Interestingly, many programs, such as the University of Sheffield’snew M.Sc. in modeling and simulation in PK and PD, serve peoplewho already work in the pharmaceutical industry. “Our studentsunderstand there is a future in quantitative pharmacology andwouldlike to shift careers into this area,” says Rostami-Hodjegan. Likewise,Gabrielsson’s new M.Sc. course, called Integrated QuantitativePharmacology, at theUniversity of Göteborg in Sweden, has garneredenormous interest from people already in industry.Without industry support, these programs wouldn’t exist.

“Universities aren’t as interested in funding the applications ofcutting-edge science, they’d rather fund its creation,” says Rostami-Hodjegan. And industry is wary of funding the training of studentsthat may join their competition.But Rostami-Hodjeganpoints out that companies that fund training

get first pick of the best talent. Until recently, most of the two annualpostdoctoral fellows trained in clinical PK/PD at the University ofNorth Carolina, Chapel Hill were hired by either of its two industryfunders—Quintiles, a Research Triangle Park–based CRO, andGlaxoSmithKline (GSK). Danhof says the Leiden Center’s funders,including Eli Lilly, Johnson & Johnson, and GSK, gobble up the fivePh.D.s they graduate each year. William Jusko chairs one of themost highly regarded US programs at the pharmaceutical sciencesdepartment at the State University of New York (SUNY) at Buffalo.He says over 85 percent of his students are actively recruited intothe pharmaceutical industry, but those in the heaviest demand havefocused on PK/PD. More would like to stay in academia, he says, butthe current climate of support from NIH ensures that only the mosthighly motivated do so.Jusko says that, among his students, the hottest topics of interest

involve biotech—particularly protein therapeutic agents—because

many future new drugs will likely be biologicals. Jusko says hisfaculty members are primarily supported by NIH grants and typicallyemploy PK/PD in almost every project that studies the mechanisticbasis of drugs in animals or people.Yet the degree to which industry uses these techniques to develop

new drug safety metrics is not well defined—leaving others inacademia optimistic, but cautious, about career prospects.HowardLee,directoroftheUniversityofSanFrancisco’sWashington,

D.C.–based Center for Drug Development Science, says that PK/PDmodeling has so far been geared mostly toward drug efficacy, butthat concern in the US Congress and among the public ensures thatsafety is going to becomemore important in the future. But he thinksthe widespread adoption of pharmacometrics is an uphill battle thatis just beginning, so he tempers his enthusiasm for the burgeoningfieldwith the pragmatism that it may be some time before drug safetybiomarkers or endpoint surrogates are sought by industry.

Advice from IndustryUnderstanding the myriad factors influencing such tough industrydecisions is hard to do outside of a company. Since most jobs arein industry, gaining insider experience is essential. Butler advisesgraduate students interested in industry to do two things: completean internship at a company and make sure that they attend criticalconferences related to drug metabolism and pharmacokinetics—such as the International Society for the Study of Xenobiotics.Most big pharma companies offer internships as do some CROs,including Cognigen.Beyond internships, Fielder-Kelly suggests that people interested

in PK/PD careers should consider working for a CRO. “My big sellingpoint is that aCROcanoffer someone tonsof experience analyzing thedata from drugs used in a variety of therapeutic areas,” she says.Understanding the entire drug development process, however,

necessitates experience in big pharma. Gabrielsson says it isimportant to start making contacts with industry early duringgraduate studies to secure internshipopportunities.Given thedearthof formal training programs, the growing number of workshops andshort courses is a good way to not only hone technical skills, butalso network with the industry leaders eager to train students inthe field. For the last 11 years, he’s taught a weeklong workshopon advanced pharmacometric-pharmacodynamic data analysis atCambridge University, which is an excellent networking opportunity.“Come visit us, present a seminar on your research project, and

aim for thesis advisers also from industry,” says Gabrielsson. “I’mhappy to mentor graduates and postdocs and am currently lookingfor a postdoc to work on both preclinical mechanistic data as well aspatient biomarker and disease data,” he adds.Given the push toward Phase 0 trials, experience modeling all

types of data is increasingly important. “Experience working withpharmacometric data from humans, or animals closest to humans,is highly sought after,” says Ed Dupuis, pharmacologist at Universityof North Carolina, Chapel Hill. But the changing world of drug safetyalso requires that scientists adopt a systems biology approach. “Wecan’t understand toxicity if we don’t understand cellular processesand how molecules interact,” says Bentley.Putting that understanding into practice will provide endless

career opportunities—especially if they help companies save moneycurrently misspent chasing dead-end products.

Virginia Gewin is a freelance science journalist based in Portland, Oregon.

“The most interesting and

exciting area in early drug

safety is to develop newsystems

for assessing toxicity.”

—David Jacobson-Kram

DOI: 10.1126/science.opms.r0900068

Director of Discovery DMPKJob Description:The Director of Discovery DMPKwill lead staff scientists and support research teams that are tasked with discovering drug candidates suitablefor exploratory assessment and clinical development.

Qualifications:

• Ph.D. in a relevant field and 8-10 years in the pharmaceutical industry. Must possess an excellent command ofADME/PK and metabolism sciences as relatedto drug discovery including the ability to:a) implement strategies regarding compound evaluation for project teamsb) manage critical DMPK issues/bottlenecks and advise project teams in the areas of: absorption, solubility, permeability and transport issues, tissue distri-bution, metabolic stability and profiling, pharmacokinetics and clearance, drug safety relating to species selection, therapeutic index, CYP inhibition, druginteractions and phenotyping, efficacy, including dosing schedules for pharmacology models and modeling clinical doses and PK/PD relationshipsc) manage a vivarium facilityd) problem-solve in laboratory operationse) identify technical consultants as needed

• Excellent data interpretation skills• Excellent oral and written communication skills in English• Excellent interpersonal, leadership and organizational skills to:a) recruit, lead, motivate, support and mentor Ph.D. scientists and associatesb) solve problems, prioritize tasks, and delegate resourcesc) set priorities with project leaders and help foster a collaborative environment with colleagues across disciplinesd) interface closely with our collaborators/strategic partners to insure timely and efficient dissemination of information

Group Leader/Associate Director—EnzymologistJob Description: The successful candidate will manage and oversee a highly skilled team of Ph.D. scientists and associate scientists responsible for in vitrocharacterization of small molecule inhibitors. The primary responsibilities of the position will include design and implementation of a variety of in vitro experi-ments to screen and profile small molecules against a variety of enzyme targets. The successful candidate should have experience working in a multidisciplinarydrug discovery environment.

Qualifications:

• Ph.D. in molecular biology, biochemistry or microbiology with 2-5 years experience in the pharmaceutical industry and proficient in mechanistic enzymologyand assay development.

• Experience in enzyme kinetics, molecular cloning, protein expression and purification• Knowledge in enzyme-ligand interaction, structure-activity relationship of inhibitors, protein structures and microbiology• Excellent data interpretation skills• Excellent oral and written communication skills in English• Excellent interpersonal, leadership and organizational skills to:a) recruit, lead, motivate, support and mentor Ph.D. scientists and associatesb) solve problems, prioritize tasks, and delegate resourcesc) set priorities with project leaders and help foster a collaborative environment with colleagues across disciplinesd) interface closely with our collaborators/strategic partners to insure timely and efficient dissemination of information

Group Leader/Associate Director-Cell BiologistJob Description: The successful candidate will manage and oversee a highly skilled team of Ph.D. scientists and associate scientists responsible for imple-mentation of all aspects of cell based assay development and screening. The successful candidate should have experience working in a multidisciplinary drugdiscovery environment.

Qualifications:

• Ph.D. in biochemistry, molecular biology, cell biology or related field is required with 2-5 years experience in the pharmaceutical industry• Extensive experience in cell biology and assay development• Strong background in signal transduction• Hands on experience on generating stable production cell lines• Excellent data interpretation skills• Excellent oral and written communication skills in English• Excellent interpersonal, leadership and organizational skills to:a) recruit, lead, motivate, support and mentor Ph.D. scientists and associatesb) solve problems, prioritize tasks, and delegate resourcesc) set priorities with project leaders and help foster a collaborative environment with colleagues across disciplinesd) interface closely with our collaborators/strategic partners to insure timely and efficient dissemination of information

Group Leader/Associate Director-Cell BiologistJob Description: The successful candidate will manage and oversee a highly skilled team of Ph.D. scientists and associate scientists responsible for assay devel-opment and screening for GPCR targets. The successful candidate should have experience working in a multidisciplinary drug discovery environment.

Qualifications:

• Ph.D. in biochemistry, cell biology or related field with 2-5 years experience in GPCR and receptor pharmacology.• Hands on experience with bioassay technologies to study GPCRs• Extensive experience in cell biology and assay development• Experience in one or more of the following disease research areas: CNS, metabolic disease, or cardiovascular diseases• Excellent data interpretation skills• Excellent oral and written communication skills in English• Excellent interpersonal, leadership and organizational skills to:a) recruit, lead, motivate, support and mentor Ph.D. scientists and associatesb) solve problems, prioritize tasks, and delegate resourcesc) set priorities with project leaders and help foster a collaborative environment with colleagues across disciplinesd) interface closely with our collaborators/strategic partners to insure timely and efficient dissemination of information

Site Location: Beijing, China; Interested candidates should submit their C.V.’s to Mr. Dake Wang at [email protected].

Website: www.Chemizon.com

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MSU IS ANAFFIRMATIVE ACTION, EQUAL OPPORTUNITY EMPLOYER.

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Faculty Positions in the Division ofMolecular Cardiology,Department of Medicine

Several tenure-track, State of Texas fundedpositions at the Assistant and Associate Profes-sor levels are available. Focus of the Divisionis Cardiovascular, with emphasis on cardiachypertrophy, remodeling and heart failure.Funded candidates with a molecular approachthat interfaces with translational initiatives areencouraged to apply. Competitive startup pack-ages, incentives and lab space are available. Corefacilities include microarray, imaging (confocaland atomic force), proteomics, cell sorting andanalysis, and laser capture microdissection. TheDivision, which is part of the TexasA&MCollegeofMedicine, is located in Temple, Texas, a vibrantcity close to Austin. In addition to research, newfaculty will instruct fellows and residents, medi-cal and/or graduate students, and will be active inpre- and postdoctoral training. Interactions withclinical researchers are encouraged through Scott& White and the Central Texas Veterans HealthCare System, major teaching hospitals of theTexas A&M Health Science Center. The CollegeofMedicine is entering a rapid growth phase withexpansion of the medical school class, and a sub-stantial number of new faculty will be recruited inupcoming years. Send CV, statement of research,training and teaching goals, and a list of 3 refer-ences to: [email protected] orKennethM.Baker,M.D., Division ofMolecular

Cardiology,TexasA&MHealth ScienceCenter,

College of Medicine, 1901 South First Street,

Building 205, Temple, Texas 76504.

The University of Delaware invites nominations and

applications for a new Chair in Energy, endowed by

the Unidel Foundation. We seek a distinguished

scholar to further strengthen the university’s interde-

partmental teaching and research programs in the

field of energy, and to lead the University of Delaware

Energy Institute (UDEI) to a position of national and

international prominence, as envisioned in the uni-

versity’s strategic plan, the Path to Prominence™.

This Chair is a university-wide position, with potential

appointments in multiple departments. The Chair will

also serve as Director of UDEI. Additional informa-

tion about UDEI and energy research at the

University of Delaware can be found at www.ener-

gy.udel.edu.

Candidates for this position are expected to hold a

Ph.D. or equivalent degree, and have a demonstrat-

ed record of accomplishments and leadership in

energy-related research and scholarship commensu-

rate with appointment to a senior faculty position in

one or more departments of the University.

Nominations and applications should be submitted

electronically to [email protected] or sent to

Energy Chair Search Committee, University of

Delaware, 4 Kent Way, Newark, DE 19716.

Application materials should include a statement of

interest, curriculum vitae, description of research and

teaching interests and accomplishments, and the

names and contact information of at least three ref-

erences. Review of applications will begin on May 1,

2009, and will continue until the position is filled.

The UNIVERSITY OF DELAWARE is an Equal

Opportunity Employer which encourages applications

from Minority Group Members and Women.

Endowed Chair in Energy

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Founded in 2003,Acceleron Pharma, Inc. is a biopharmaceutical companydeveloping therapeutics formusculoskeletal, metabolic and cancer-relateddiseases. In the complex and rapidly evolving field of drug discovery anddevelopment, the depth of the team and the way the team members worktogether are two of the most critical success factors. We have a uniqueculture, team, and approach that is rapidly translating our ideas and assetsinto drugs that will make a significant difference in patients’ lives.

Acceleron has raised over $85M in venture financing including $31Mfrom our Series C financing inOctober 2007. We have assembled a strongmanagement and scientific team comprised of established leaders withsignificant biotechnology and pharmaceutical industry experience. Weare seeking talented and passionate individuals who thrive in a dynamic,fast-paced, team-oriented and collaborative environment to be part ofour success.

Post Doctoral Scientist

Position Overview:We have an immediate opening for a post doctoralscientist in our drug discovery group. This person will be studying theeffect of various molecules of TGF beta family on erythropoiesis. He/shewill set up various in-vitro and in-vivo assays to study development ofred blood cells.

Basic Qualifications: This position requires a Ph.D. in Cell Biology orrelated discipline with 0 to 1 year of post doctoral experience. He/ shemust be proficient in molecular biology, gene expression and cell biologytechniques. Prior experience in studying hematopoeisis/ erythropoeisiswill be a plus. This individual should be able to work in a multi-disciplin-ary environment and possesses strong communication skills.

Please apply at: www.acceleronpharma.com.

President

TheGladstone Institutes, a freestanding biomedical research organi-zation af�liated with the University of California, San Francisco, isrecruiting an outstanding scientist to serve as President. Gladstonefocuses on cardiovascular disease, HIV/AIDS, and neurodegenera-tive disorders and has also established a Center for TranslationalResearch.

Duties of the position include long-range strategic planning, promot-ing the basic science and translational research, and fundraising.Candidates should have established scienti�c excellence, provenleadership ability, management skills, and demonstrated fundraisingcapability. Experience with the private sector would be welcomed.Competitive salary provided.

All inquiries, nominations and application materials will be kept instrict con�dence. Formore information about Gladstone, please visitour website at www.gladstone.ucsf.edu.

Review of resumeswill begin immediately. This positionwill remainopen until �lled; however, for priority consideration, applicationmaterials should be received no later thanMay 1, 2009.Applicationsand nominations may be sent to:

Susan Dzierson, Human Resources Of�cer

The J. David Gladstone Institutes

1650 Owens Street

San Francisco, CA 94158

E-mail: [email protected]

Fax: 415-355-0910

The J. David Gladstone Institutes and UCSF are Af�rmativeAction/Equal Opportunity Employers. They undertake af�rmativeaction to assure equal employment opportunity for underutilizedminorities and women, for persons with disabilities, and forcovered veterans. Gladstone and UCSF seek candidates whoseexperience, teaching, research or community service has preparedthem to contribute to our commitment to diversity and excellence.T

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Breast Cancer Scientist

The JohnWayneCancer Institute at SaintJohn’s Health Center is seeking a highlyqualified Ph.D. applicant for a facultyappointment in basic science and trans-lational cancer research at the AssistantorAssociatemember level, depending onthe candidate’s qualifications. The suc-cessful candidate will develop a researchprogram in human breast cancer in anenvironment that encourages collab-orative team science. Excellent clinicalspecimen resources are available.

Our world-renowned breast cancer program in cancer research,treatment, and diagnosis, headed by Armando E. Giuliano, M.D.,clinically and by Dave S.B. Hoon, Ph.D., in laboratory research,offers opportunities for creative science.

The ideal applicantmust be capable of competing for government grantfunding with the goal of developing an independent research programand must have demonstrated productive and innovative breast cancerresearch. A minimum of 2 years’ experience beyond postdoctoralfellowship is required. The salary, which includes a comprehensivebenefit package, will be commensurate with experience.

Please send a cover letter stating current and future research interests,three references, curriculum vitae, and most significant publicationsto:Armando E. Giuliano, M.D., Chief of Science and Medicine

John Wayne Cancer Institute

2200 Santa Monica Blvd.

Santa Monica, CA 90404

or email: [email protected]

The University of Colorado Denver School of Medicine seeks appli-cants for the position of Chair of the Department of Pharmacology.The Department consists of 24 faculty members whose interests spanneurosciences, cell biology, drugs of abuse, genomics and bioinformat-ics, signal transduction, lipid mediators, and structural biology. TheDepartment occupies dramatic new laboratories and offices in twintowers of the Research Complex at the new University of ColoradoDenver Anschutz Medical Campus.

The Department of Pharmacology has a large basic science researchprogram with more than $19 million in annual research funding. TheDepartment has won numerous awards for the teaching of medicalstudents. Details are available at the departmental web site: http://pharmacology.ucdenver.edu/index.shtm.

The Chair of the Department of Pharmacology reports to the Vice-Chancellor for Health Affairs/Dean of the School of Medicine andparticipates with other department chairs and faculty to develop Schooland Department programs, curriculum, administration, and budgetaryplanning and implementation.The position requires excellence in teach-ing, demonstrated administrative ability/leadership and leadership inresearch and scholarly activity.

Review of applications will continue until the position is filled.Appli-cants should apply online at the https://www.jobsatcu.com websiteusing posting number 806418. Questions about the application processmay be directed to [email protected].

The University of Colorado Denver is committed to the recruitmentand employment of a diverse faculty. We encourage applications

from women and minorities.

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�eMaine Medical Center Research Institute (MMCRI) and theDivisions of Hematology/Oncology and Pulmonary Medicine inthe Department of Medicine at Maine Medical Center (MMC)seek to recruit a physician/scientist with an M.D. or M.D./Ph.D.degree, clinical training in oncology or pulmonology, and re-search experience in lung cancer or metastatic disease to thethorax. Applications are invited from translational researchinvestigators who are using modern cell, molecular and/orgenetic methods to elucidate molecular mechanisms of lung

cancer or thoracic neoplasms. Translational investigators with ademonstrated interest in lung cancer growth, invasion and metas-tasis, tumor microenvironment, molecular targets for therapeu-tics, biomarkers for diagnosis, or response and prognosis areencouraged to apply. Institute faculty have access to excellent

resources, including generous start-up funds and space in a newstate-of-the-art research building. MMCRI has outstanding corefacilities for DNA and protein analysis, stem and progenitor cellisolation, confocal microscopy, mouse transgenic, and small

animal imaging. �is position will be associated with MMCRI’sCenter for Clinical and Translational Research. �e successfulcandidate will also be expected to interact with existing clinicalprograms at MMC, to participate in graduate medical educationprograms, and to provide research mentoring to pulmonary

fellows. Clinical opportunity to participate in a multidisciplinarythoracic/oncology clinic is available.

�e successful candidate will have an outstanding record of aca-demic achievement and extramural funding and will complementexisting basic and clinical research programs at MMCRI. Juniorfaculty with an exceptional record of achievement will be consid-ered. Rank and salary will be commensurate with quali�cationsand experience. �e Portland area o�ers an environment rich incultural and recreational opportunities. Applicants should send acurriculum vita and a brief statement of research interests to:

Cli�ord J. Rosen, M.D., Director, Center for Clinical andTranslational Research, MMCRI, 81 Research Drive,

Scarborough, ME 04074-7205

Senior PhysicianScientist

LungCancer

M A I N E M E D I C A L C E N T E R R E S E A R C H I N S T I T U T E

www.mmcri.org

Call for applications for

Associate Chief Scientist

RIKEN, Japan

RIKEN, one of Japan’s largest researchorganizations, carries out advanced basic andapplied research in a wide range of �elds, includingphysics, chemistry, medical science, biology, andengineering. RIKEN is now accepting applicationsfor the position of Associate Chief Scientist. Thereare currently several openings. This position isopen to all research �elds, but priority will be givento those areas which can be expected to makethe best use of RIKEN’s resources and achieveremarkable progress.

1. Quali�cations

Self-disciplined scientists with a long-term vision ofthe next generation of scienti�c endeavor, and withthe ability and research record to preside over theirown autonomous laboratories will be considered ascandidates for this position.2. Laboratory & Budget(1) The Associate Chief Scientist will establishand manage a laboratory independent of ChiefScientists and other PIs.(2) An initial fund of 20 million yen (in principle)and a quota for hiring �xed term contract researchscientists will be provided for the start-up of theAssociate Chief Scientist lab.(3) The Associate Chief Scientist is eligibleto apply for funding from within and outsideRIKEN.(4) To allow for greater focus on research andgreater �exibility, the Associate Chief Scientisthas relatively fewer administrative dutiescompared to a Chief Scientist.

3. RemunerationAnnual salary with a bonus system. Other pointsare as described in RIKEN regulations.4. Type of employmentThe position is tenured, subject to RIKEN’smandatory retirement age of 60.5. Starting date of employmentApril 1, 2010 (in principle)6. Application deadline17:00 on Friday, May 15, 2009 (Japan StandardTime). All application documents should be sent bypost mail or hand-delivered directly to theAssociateChief Scientist Desk. If you mail the documents,please send as certi�ed mail.

Additional information and application forms areavailable athttp://www.riken.jp/engn/r-world/info/recruit/index.html.

AssociateChief Scientist Desk, ResearchPersonnelSection, Advanced Research Promotion Division,RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198Japan. E-mail: riken-acs(at)riken.jp.

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Director-Glennan Center forGeriatrics and Gerontology

EVMS seeks applications for the position ofDirector of theGlennanCenterfor Geriatrics and Gerontology with a faculty appointment in the Depart-ment of Internal Medicine at the level of associate professor or professor.Candidates should have an MD or PHD degree, must have demonstratedexcellence in research and possess exceptional leadership qualities. TheDirector will have the opportunity to build a prominent center, emphasiz-ing excellence in research, teaching, and clinical care related to aspects ofaging. EVMS is undergoing a significant expansion in the areas of basic andtranslational research. There are significant resources available, includingexcellent laboratory space and endowed professorships for recruitment ofthe Center Director and additional faculty.

The Glennan Center for Geriatrics and Gerontology has gained nationaland international recognition for excellence in immunology, driving andcognition in the context of aging research. The Center is also a leader inclinical care, providing innovative services to meet the special health careneeds of older adults across a full range of practice settings from indepen-dent living to assisted living, long-term care, palliative care, and hospitalcare. The Center currently consists of eleven facultymembers, and offers acomprehensive program for clinicians and scientists that provides trainingin geriatrics and gerontology formedical students, residents, fellows, otherhealth care professionals and junior faculty members.

EasternVirginiaMedical School is located in coastal southeasternVirginiain the nation’s 27th largest metropolitan statistical area. The region offerspremier waterfront communities, large beaches, excellent golf, tennis,sailing and other recreational opportunities, and top ranked schools.

Please send a letter of interest including a current curriculum vitae to theExecutive Search Committee by e-mail at [email protected].

AA-EOE

Tenure-track Faculty PositionsBacteriology, Virology and Immunology

The Department of Medical Microbiology and Immunologyat the University of Toledo College of Medicine is seekingto hire at least one tenure-track faculty member at the levelof Assistant/Associate/Full Professor. Candidates must holda Ph.D., M.D., or equivalent degrees and have at least threeyears of relevant postdoctoral experience (Assistant Professor)or faculty appointment (Associate/Full Professor), as well asextramural funding. Successful candidates will be expectedto develop/maintain an externally funded, basic and/or trans-lational research program and contribute to teaching in ourmedical and graduate programs.

Applications including (a) CV, (b) a brief summary of researchinterests, past accomplishments, and future plans, and (c)names and addresses of three references should be sent elec-tronically to: [email protected]. Applications arecontinuously reviewed. For further details regarding these posi-tions see http://hsc.utoledo.edu/depts/micro/index.html.

The University of Toledo is committed to diversity andequal opportunity. Applications from women and minority

candidates are strongly encouraged.

Tenure-Track Faculty Position:Complex Systems in Transportation

School of Engineering

College of Engineering and Mathematical Sciences

The School of Engineering in the University of Vermont College ofEngineering andMathematical Sciences (UVMCEMS)will be seekinga tenure-track faculty member in Complex Systems in Transportation,specifically in Transportation Activity Modeling, for a fall, 2009 startdate. This opportunity capitalizes upon a core UVM CEMS invest-ment in complex systems (see CEMSComplex SystemsCenter website:www.uvm.edu/~cems/complexsystems) and the designation of UVMas a National University Transportation Center (UTC) by USDOT todevelop transdisciplinary research in Sustainable Transportation Sys-tems (see www.uvm.edu/~transctr).

Candidates for this position will have strong complex systems analysisandmodeling experience based on real-world data, with successful appli-cants also having demonstrated interest in policy-relevant applicationsand an appreciation of interdisciplinary approaches and perspectivesin engineering in both teaching and research. The candidate must beexperiencedwith complex systems approaches to transportation activityanalysis and will be expected to teach undergraduate systems engineer-ing courses in addition to graduate courses in systems and transporta-tion demand modeling. Multimodal interests are particularly desirable– e.g., with focus on air versus rail or rural demand responsive transit.The successful candidate will contribute to undergraduate and graduateinstruction andmaintain an active program of externally funded researchand graduate student advising. Interdisciplinary collaborations will behighly valued and development of a funded research program in partner-ship with the UVM Transportation Research Center is expected.

The College of Engineering andMathematical Sciences at UVM is oneof the fastest growing on campus, with excellent faculty and studentsin engineering, computer science, and mathematics and statistics and aleader in high-profile, multi-disciplinary partnerships across campus aswell as “holistic” and interdisciplinary approaches to 21st century engi-neering education. CEMS is also home to the university-wide VermontAdvanced Computing Center – a high performance computing facilityserving diverse, computationally intensive research programs acrossUVM and with UVM partners (www.uvm.edu/~vacc). The successfulcandidate will join this growing community, with approximately 30permanent faculty colleagues in CEMS’ School of Engineering (http://www.uvm.edu/~soe/) itself. Candidates must have a Ph.D. degree inan engineering field, a proven record of scholarly activities, and showpotential for strong performance in research and teaching in one ofthe School’s accredited civil, electrical, environmental, or mechanicalengineering programs.

Qualified applicants are required to apply online atwww.uvmjobs.com(Search posting # 00021678).

Qualified applicants are also encouraged to contactDr. LisaAultman-Hall at 802-656-1312 or [email protected] to find outmore information about this position.

Screening of applications will begin April 1, 2009, and continue untilthe position is filled.

The University of Vermont is an Affirmative Action/EqualOpportunity Employer. All Departments are committed to increasing

faculty diversity and welcome applications from women andunderrepresented ethnic, racial and cultural groups and from peoplewith disabilities. The University is committed to building a culturallydiverse educational and research environment. Applicants will berequested to include in their cover letter information about how they

will further this goal.

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University of Plymouth

www.plymouth.ac.uk/vacancies

Director of the Marine InstituteConsistently ranked one of the top modern universities, Plymouth has a strong

record of excellence and innovation across its teaching, learning and research

activities and is distinguished by its long-term engagement with employers. As the

enterprise university, it delivers outstanding economic, social and cultural return for

business, the public sector and its wider community.

With around 30,000 students – including those studying at its partner FE colleges

throughout the South West – and 3,000 staff, Plymouth is now one of the largest

universities in the UK. It has a strong commitment to widening participation in higher

education in the region and its body of University of Plymouth Colleges has been

specifically developed to help fulfil that commitment.

Plymouth is one of the top 50 UK universities for research, the results of the 2008

Research Assessment Exercise showing that the majority of the area submitted by

the university included world-leading research, achieving the highest rating possible.

Overall, 80% of the research was judged as being of international repute.

Plymouth’s four strategic subject areas of Marine Sciences; Health and Biomedicine;

Creative Arts, Design and Technology and Economic, Social and Environmental

Sustainability build on identified areas of strength and excellence and are aligned with

regional economic priorities.

To help students work effectively in a global economy, Plymouth has embarked on

an internationalisation project to create and deliver a strategy which will see it

partner some of the best institutions in the world, increase collaborations in research

projects, share academic curricula and extend exchange programmes and internships

for staff and students.

Rated the best-performing UK university of the past two years for its green

credentials, Plymouth is home to the Centre for Sustainable Futures one of its

Centres for Excellence inTeaching and Learning – which aims to embed sustainability

in the curriculum, campus and community.

The university is now seeking to appoint an outstanding, visionary and enterprising

leader as Director of the Marine Institute who will take the university forward to be

world leading in the key maritime areas.

For an informal discussion please contact Professor Maureen Neal, Deputy

Vice-Chancellor on 01752 582009 or email [email protected]

although applications must be made in accordance with the details shown

below. Ref:A1062

We offer 35 days holiday plus public holidays and a relocation package is available.

Salary within the range £60,297 - £74,825 pa

Closing date: 12 Noon, Monday 30 March 2009

A Final Salary Pension Scheme is available.

Please request an application pack, quoting

Ref & Job Title, via:

www.plymouth.ac.uk/vacancies

Email: [email protected]

Tel: 01752 588199 (24 hour answerphone)

Promoting Equality and Diversity

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THE JOHNS HOPKINS UNIVERSITY

Oncology BiostatisticsSidney Kimmel Comprehensive Cancer Center

BIOSTATISTICIANSStaff (MS) and Faculty (PhD) Level Positions

TheBiostatisticsDivision of the SidneyKimmel ComprehensiveCancer Center at JohnsHopkins, foundedin 1988, is a leader in the statistical applications in cancer research. We conduct methodologic researchin Biostatistics and Bioinformatics to advance cancer research, provide biostatistics and bioinformaticssupport to medical investigators in cancer and other conditions, and teach research methodology in awide variety of academic programs in the Johns Hopkins Schools of Public Health and Medicine. Thedivision currently has 7 doctoral level faculty and 5 Master’s level biostatisticians/bioinformaticians.We are recruiting 2 M.S. staff and 1 Ph.D. level faculty with interests in both methodologic and col-laborative biomedical research. These new faculty and staff positions will expand a highly successfulgroup of quantitative scientists working collaboratively with both clinical and basic science faculty inthe Johns Hopkins School of Medicine. The Division has strong research and teaching connections withthe Departments of Biostatistics and Epidemiology in the Bloomberg School of Public Health with anopportunity for joint appointments. Please visit our website: www.cancerbiostats.onc.jhmi.edu.

Staff Biostatistician: These positions require a Master’s degree in biostatistics, computer science orstatistics and practical experience in biomedical study design and analysis. Strong written and oral com-munication skills are necessary, and experience with a range of statistical software is required.

Tenure Track Faculty: Suitable candidates will hold a Ph.D. in statistics, biostatistics, epidemiologyor related quantitative fields, with interest and experience in clinical trials, diagnostic/screening stud-ies, and translational research, primarily in cancer. We welcome applications from candidates at anyacademic rank. At this time we are not recruiting for individuals whose primary interest and experienceis in Bioinformatics.

Application Procedure:Applicants should send a Curriculum Vitae (including personal website URLif available), letter of application and two or more letters of reference to: Steven Goodman, MD, PhD,Director, Search Committee, Division of Biostatistics, 550 North Broadway, Suite 1103, Baltimore,

MD, 21205-2013,

Applications will be considered until the positions are filled. E-mail applications and inquirieson the status of an application can be directed to Helen Cromwell, Administrative Manager,[email protected].

The Johns Hopkins University is an Equal Opportunity/Affirmative Action Employer. We stronglyencourage qualified women and under-represented minorities to apply.

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POSITIONS OPEN

POSTDOCTORAL FELLOW POSITIONSin Bio-Inspired Engineering

The Wyss Institute for Biologically Inspired Engi-neering at Harvard University invites applications fora number of Postdoctoral Fellows who will hold aca-demic appointments in one of the three collaboratingHarvard Schools: Harvard Medical School, The Schoolof Engineering and Applied Sciences, or the Faculty ofArts and Science. The mission of the Wyss Institute isto discover the engineering principles that nature usesto build living things; to pursue the high-risk researchthat is fundamental to advance this effort; and to harnessthese insights to create biologically inspired materialsand devices to advance human health and improve theenvironment, thereby revolutionizing clinical medicineand creating a more sustainable world. Applicants arespecifically sought working in the following knowledgeplatforms: biomimetic microsystems; biomaterials evo-lution; programmable nanomaterials; anticipatorymedical devices; adaptive architecture.A Ph.D. in a related field is required. Applications,

assembled as single PDF files, should contain curriculumvitae, a cover letter describing research interests and goals,a full list of publications, copies of up to three relevantscientific papers, and names and contact informationfor at least three writers of letters of recommendation,who might be contacted as references. Applicationsshould be sent to e-mail: [email protected]. Applications will be reviewed beginning March2009. Later applications are also welcome until thepositions are filled. Harvard University is an Equal Op-portunity/Affirmative Action Employer, and applications fromwomen and minority candidates are strongly encouraged.

VISITING ASSISTANT PROFESSOREcology/Environmental Sciences

The Department of Biological Sciences at UnionCollege invites applications for a one-year VisitingAssistant Professor, to begin in September 2009. Thesuccessful candidate will teach a course in each ofour three trimesters: ecology (lecture and lab); intro-duction to environmental studies (lecture and lab);and one course in our first year majors_ sequence. APh.D. and a strong commitment to undergraduateeducation are required. Union College is a highly se-lective liberal arts college with an emphasis on stu-dent research and interdisciplinary programs. Pleasesend a letter of application with curriculum vitae, astatement detailing teaching experience and phi-losophy, a separate statement of research interests,and three letters of recommendation to: Ecology/Environmental Sciences Visitor Search, Departmentof Biological Sciences, Union College, Schenectady,NY 12308.Or e-mail: [email protected]. Re-view of applications will begin April 3, 2009, and con-tinue until position is filled.

Union College is an Equal Opportunity Employer and stronglycommitted to student and work force diversity.

A POSTDOCTORAL POSITION at The Chil-dren_s Hospital of Philadelphia and The University ofPennsylvania is available immediately. The position isin the laboratory of Dr. Rodney M. Camire and willexamine mechanisms contributing to blood coagu-lation factor specificity and function. Biochemicalapproaches both in vitro and in vivo are employed tocharacterize recombinant blood clotting proteins. Ap-plicants for this position should have a strong back-ground in protein biochemistry and have molecularbiology experience. Experience with murine modelsis also desirable. Candidates for this position shouldhave a Ph.D. or M.D.-Ph.d. degree, have good commu-nications and interpersonal skills, be highly motivated,and be willing to work on a multidisciplinary team.Highly competitive salary and benefits are offered.Curriculum vitae should be sent to: Dr. Rodney M.Camire, The Children_s Hospital of Philadelphia,ARC, Room 302, Philadelphia, PA 19104. E-mail:[email protected].

UND Research Foundation

The UND Research Foundation operates a new state-of-the-art, 50,000SF research facility with laboratories in Life Sciences and AdvancedTechnologies.

Research Director (0811E)

TheUNDResearch Foundation is seeking a dynamic and highlymotivated Director ofViral Therapeuticsthat serves as the organizational leader for the development of therapeutic antibodies and vaccines andmanages a group of 8-10 scientists and staff. The Director will also be responsible for leading the Centerof Excellence in Passive Therapeutics for viral diseases including the advancement of several productcandidates with corporate and academic partners.

Applicant must possess a Ph.D. with proven expertise in Virology and Immunology and knowledge ofpre-clinical and clinical trials. Candidates must have demonstrated capabilities in leading a researchand development team for viral therapeutics in BSL-3/3+ labs and in successful collaborations with theprivate sector and public institutions.

Research Scientist – Immunology (0811F)

The UNDRF is seeking a research scientist that has a Ph.D. in Immunology, or a related BiologicalScience, with demonstrated research experience in immunology and/or immunotherapy-based research.Technical expertise should include host immunological responses; development and assessment thera-peutic antibodies; and significant experience with in vitro and in vivo models. Candidate is required tointeract with others and have excellent verbal and written communication skills.

Research Scientist – Virology (0811G)

The UNDRF is seeking a research scientist that has a Ph.D. in Virology, or a related Biological Science,with demonstrated research experience in viral assays and/or viral therapeutics-based research. Technicalexpertise should include in vitro and in vivo models of viral infection, preferably on BSL-3 pathogenssuch asWNVorHPAI; assessing therapeutic antibodies; andmolecular engineering. Candidate is requiredto interact with others and have excellent verbal and written communication skills.

Competitive salaries commensurate with qualifications and experience as well as excellent benefits willbe provided to successful candidates.

Send C.V. to UNDRF, Suite 2050, 4201 James Ray Drive, Grand Forks, ND 58202, or email [email protected] , or fax to (701) 757-5101. Reference Job Code 0811E, F, orG in all correspondence.Visit http://www.undrf.org/jobs for more details.

AA/EOE

From climate change to health pandemics, the UK’s national security and prosperity depends on how we work with other nations. This requires a modernand effective Foreign and Commonwealth Office. The FCO provides a unique and flexible network of staff, embassies and offices around the world whichserves all of UK Government, helping deliver three essential services: supporting the British economy; supporting British nationals abroad; and managedmigration for Britain. The FCO has four policy goals: to prevent counter-terrorism, weapons proliferation and their causes; to prevent and resolve conflict;to promote a low carbon, high growth global economy; and to develop effective international institutions, above all the UN and EU.

In this key, newly-created advisory post, the CSA will report to the Permanent Under-Secretary. The FCO is committed to evidence-based policy makingand science, technology and innovation are elements of many of the Department’s missions. There is, however, little capacity within the Department forgenerating scientific evidence and a need to build a strong ‘‘intelligent customer’’ capability. The CSA’s core role is to ensure that the Department’s policiesand operations, and its contribution to wider government issues, are underpinned by excellent science, technology and innovation advice. This will involve:providing advice to the Foreign Secretary, Ministers and officials on science, technology and innovation; engaging actively with the cross-Governmentcommunity of science advisers: building partnerships with stakeholders across the UK and international science and engineering community; promotingthe FCO’s public science messages alongside the Government CSA; strengthening scientific and engineering capacity in the FCO.

The successful candidate will be a scientist of high academic standing, for example an FRS or FREng, with a strong international profile. He/she willneed broad links to academic networks in the UK and internationally, with the ability to span a wide and varied scientific brief, as well as outstandinginterpersonal and influencing skills. Strategic awareness will be an asset, with the capacity to identify policy areas where science, technology orinnovation should play a role, and the ability to communicate complex scientific advice so that Ministers, officials and the public can understand it.

The successful candidate will need to be a UK national and willing and able to be security cleared to the highest (‘‘developed vetting’’) level.

The FCO is committed to being an equal opportunities employer and values and welcomes diversity.

For further information about the role, please visit www.rrapublicsector.comApplications, including a full CV, supporting statement and monitoring questionnaire, should be sent by email to

[email protected] quoting reference FCO-CSA or to Russell Reynolds Associates, 24 St James’s Square,London SW1Y 4HZ or telephone +44 (0) 20 7830 8052/8083 for assistance.

Closing date: 27th March 2009

Chief Scientific AdviserPart-time – c. 3 days per week

c. £120,000 pro rata – London

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Pathology is one of the foundations of clinical medicine

and research into human disease, and the Chair of

Pathology and Head of Department at the University of

Melbourne will ensure the Department continues to be a

major contributor to the teaching, research and knowledge

transfer activities of the University and the Faculty.

�e Chair will come from either a science or medical

background, and will lead the development of pathology

teaching and research as molecular medicine advances and

the Melbourne Model is implemented.

�e University of Melbourne is globally recognised as one

of the world’s best, and continues its 150 year tradition

of excellence in intellectual, cultural and professional

development locally and internationally.

Salary: An attractive salary package including

17% superannuation will be negotiated with the

successful candidate.

Job No: 0001777.

For position information and to apply online go to

www.hr.unimelb.edu.au/careers, click on ‘Job Search’

and search under the job title or job number.

AnEqual Opportunity employer.

CRIC

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16K

Chair/Head of Department – Pathology.

Department of Pathology, Faculty ofMedicine,Dentistry andHealth Sciences,Melbourne,Australia

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Assistant Professor, Structural BiologyChildren’s Hospital BostonHarvard Medical School

The Program in Cellular and Molecular Medicine at Children’s HospitalBoston in partnership with the Department of Biological Chemistry andMolecular Pharmacology (BCMP) at Harvard Medical School is recruitingtenure track faculty at the rank of Assistant Professor. Our Program (alsoknown as the Immune Disease Institute) is highly interactive and offers out-standing opportunities for collaboration and technical support. The successfulcandidate will be offered a competitive start-up package. He/she will directan independent research laboratory and his/her work will complement andenhance the efforts of our distinguished faculty in cell biology, immunology,inflammation, vascular biology, infectious disease and cancer. This is part ofa major initiative in structural biology involving several recruits, space in anew building on Longwood Avenue, and substantial new funding.

We are seeking a candidate who integrates macromolecular structure andbiological function, especially someonewhoworks on fundamental problemsinvolving signal transmission in extracellular and cytoplasmic environmentsand across cell membranes.Approaches usingmolecular dynamics and spec-troscopy, protein structure prediction and design, X-ray crystallography, elec-tron microscopy, single molecule studies, and innovative light microscopywill be of special interest. The structural biology initiative will be able todraw on available resources at Children’s Hospital and the HMS Center forMolecular and Cellular Dynamics (CMCD).

Please forward a cover letter requesting consideration by the search com-mittee, curriculum vitae, reprints of key publications, letters separately sentfrom three referees, and a two-page statement of research interests includingprevious contributions and future research plans, no later thanMay 1, 2009 to:TimothyA. Springer and StephenC.Harrison, SearchChairs, 3 Blackfan

Circle – room 3103, Boston, MA 02115; [email protected].

Children’s Hospital Boston and Harvard Medical School areAffirmative Action/Equal Opportunity Employers. Women and minority

candidates are strongly encouraged to apply.

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CONFERENCE

www.keystonesymposia.org • 1-800-253-0685 • 1-970-262-1230Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization that is directed and supported by the scientific community.

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POSITIONS OPEN

STAFF FELLOW (Biology/Microbiology)Department of Health and Human Services,

Food and Drug AdministrationCenter for Biologics Evaluation and Research,

Office of Vaccines Research and ReviewDivision of Bacterial, Parasitic and Allergenic

Products

Department of Health and Human Services, Foodand Drug Administration, Center for Biologics Eval-uation and Research, Office of Vaccines Research andReview, Division of Bacterial, Parasitic and AllergenicProducts, Laboratory of Mycobacterial Diseases andCellular Immunology has a tenure-track position fora Biologist with a Ph.D. in biology, microbiology,immunology, or a related field. The candidate is ex-pected to contribute to an ongoing research programrelated to the pathogenesis and immunology of tuber-culosis, and to participate in the regulation of newbacterial vaccines. The goals of the research programare to better understand the pathogenesis of Myco-bacterium tuberculosis and to identify and evaluatenew vaccine candidates for the prevention of tuber-culosis. The Laboratory of Mycobacterial Diseases andCellular Immunology_s regulatory responsibilities in-clude the review of vaccines against tuberculosis, malaria,tularemia, and other bacterial pathogens. The Laboratoryis composed of a diverse group of scientists investigat-ing the pathogenesis and immunology of intracellularorganisms.Qualifications: Eligible individuals will beU.S. citizens

or U.S. permanent residents with a Ph.D. in an appro-priate field and further relevant postdoctoral experiencewith a clear record of scientific productivity. Candidateswith demonstrated interests in mycobacterial vaccinesand the pathogenesis of M. tuberculosis, significant lab-oratory experience in bacterial pathogenesis, infectiousdisease immunology, and animal models of infection,and at least three years of postdoctoral experience arestrongly preferred.Salary range: Salary is commensurate with educa-

tion and experience, with an excellent benefits package.Location: NIH campus in Bethesda, Maryland.How to apply: Candidates should send a resume or

curriculum vitae, bibliography, a brief summary of re-search accomplishments and interests, and the names/contact information for three references by April 30,2009, to e-mail: [email protected].(Reference job code: OVRR/SM.)For further information, please visit our website:

http://www.fda.gov/cber/inside/vacancy.htm.Department of Health and Human Services is an Equal Op-

portunity Employer with a smoke-free environment.

POSTDOCTORAL POSITIONin Pediatric Oncology

A funded Postdoctoral position is available in theresearch laboratory of Dr. David Loeb in the De-partment of Oncology of Johns Hopkins University.The laboratory has basic and translational projects insarcoma biology and tumor angiogenesis, with a focuson the role of WT1 in these processes. The positionrequires an M.D. or a Ph.D. and experience in basiccellular and molecular biology. Knowledge of genetransduction methodologies and experience study-ing angiogenesis and using small animal models aredesirable. Starting salary will be commensurate withexperience. Please submit a letter of interest and cur-riculum vitae to: Dr. David Loeb, Johns HopkinsUniversity, Cancer Research Building, 1650 OrleansStreet – Room 2M51, Baltimore, MD 21231. E-mail:[email protected]; fax: 410-955-8897.

CAREER OPPORTUNITY

Doctor of Optometry (O.D.) degree in 27 monthsfor Ph.D.s in science and M.D.s. Excellent career op-portunities for O.D./Ph.D.s and O.D./M.D.s in re-search, education, industry, and clinical practice. Thisunique program starts in March 2009, and featuressmall classes and 12 months devoted to clinical care.Contact the Admissions Office, telephone:

800-824-5526 at the New England College of Op-tometry, 424 Beacon Street, Boston, MA 02115.Additional information at website: http://www.neco.edu, e-mail: [email protected].

POSITIONS OPEN

ASSISTANT PROFESSOR(MARINE ECOLOGY)

The U.S. Coast Academy, located in New London,Connecticut, invites applications for a full-time, per-manent, tenure-track academic faculty position in thebroad area of human impacts on marine ecology com-mencing fall 2009. The successful candidate will teachundergraduate courses in marine pollution for marinescience majors and oceanography for nonsciencemajors.Additional opportunities include undergraduate re-search and the development and teaching of upper levelcourses within the marine and environmental sciencesmajor appropriate to the candidate_s specialty. In addi-tion, the successful candidate will be expected to de-velop connections to the Coast Guard_s marine safetyprograms such as pollution prevention and response,providing technical expertise and input to strategicdecision making.Candidates should possess a Ph.D. degree in marine

ecology, marine science, oceanography, or related field.Undergraduate teaching experience is preferred;

applicants with background in geographic informa-tion systems are encouraged to apply. Academic rankwill be based on qualifications and experience; salariesare highly competitive.Additional information is provided on the USA-

JOBS website: http://www/usajobs.gov., keyword:Marine Ecology; location: New London, Connecticut,or by contacting Professor SamWainright, telephone:860-444-8653; e-mail: [email protected], by March 31, 2009, a letter of application

summarizing specific qualifications, a current curric-ulum vitae, statement of teaching philosophy, andnames, addresses, and telephone numbers of threereferences to:

Science DepartmentU.S. Coast Guard Academy

Attn: Search Committee (Marine Ecology)27 Mohegan Avenue

New London, CT 06320-8101

Applications may also be sent to fax: 860-444-8627, Attn: Dr. Sam Wainright, or e-mail: [email protected] citizenship restrictions may ap-ply. Women and minority candidates are encouraged to apply.The U.S. Coast Guard Academy is an Equal Opportunity, Af-firmative Action Employer.

PHYSIOLOGIST/ANATOMIST

The Department of Health Sciences in the Collegeof Public Health at East Tennessee State University(ETSU) seeks applications for a tenure-track posi-tion at the ASSISTANT PROFESSOR level openingin August 2009. The Department offers an under-graduate degree in Health Sciences with concentrationsin microbiology and human health. The Departmentalso has an undergraduate honors program and a jointgraduate program with the Department of BiologicalSciences offering an M.S. degree with a microbiologyor biology concentration. The position requires teach-ing undergraduate lecture and laboratory courses inanatomy/physiology and upper division human physi-ology. Direction of student research at graduate andundergraduate levels is expected. Qualifications: anearned Ph.D. (or completion of a Ph.D. prior to be-ginning the position) in a relevant field with universitylevel teaching experience in anatomy/physiology. De-velopment of an extramurally fundable research pro-gram that complements the mission of the Departmentand the College of Public Health is expected. Screeningof applicants will begin in April 2009. Salary will dependon qualifications and experience. Please submit letterof application, completed ETSU application (website:http://www.etsu.edu/humanres/appindex.htm),curriculum vitae, description of research interests, andcontact information for three references to:Dr. RanjanChakraborty, Associate Professor and Chair, EastTennessee State University, Department of HealthSciences, P.O. Box 70673, Johnson City, TN 37614-1709. E-mail: [email protected]. Electronic submis-sions are encouraged.

POSITIONS OPEN

BACTERIAL PATHOGENESIS

POSTDOCTORAL FELLOW position is avail-able immediately to join the collaborative researchgroup of Dr. Jeffrey D. Cirillo studying tuberculo-sis pathogenesis. Selected individual will be primarilyresponsible for conducting independent research onmycobacterial pathogens and publication of results.Research will emphasize the molecular, cell biolog-ical, live animal molecular imaging, and immuno-logical characterization of virulence determinants inmycobacteria and their interactions with the host inmice and guinea pig virulence models. Ph.D. requiredand a record of productive experience in molecularbiology of bacterial pathogens preferred. Send curric-ulum vitae and names and addresses of three referencespostmarked by April 15, 2009 (or until a suitable can-didate is found), to: Dr. Jeffrey D. Cirillo, Depart-ment of Microbial and Molecular Pathogenesis,Texas A&MHealth Science Center, MS 1114, 467Reynolds Medical Building, College Station, TX77843-1114. Fax: 979-845-3479; e-mail: [email protected]. Contact:Dr. Cirillo, telephone:979-458-0778 for additional information. Texas A&MUniversity System Health Science Center is an Affirmative Action/Equal Opportunity Employer and encourages applications fromwomen and minorities.

POSTDOCTORAL FELLOWSHIPSIN TOXICOLOGY

University of Michigan

Research training fellowships in toxicology are avail-able through an interdepartmental National Instituteof Environmental Health Sciences/NIH-sponsoredtraining program. The training program emphasizesinterdisciplinary research training in mechanistic toxi-cology with applications to prevention of human dis-ease. Research areas of the faculty include molecular,genetic, epigenetic, cell signaling, metabolic, and oxi-dative stress mechanisms of toxicology with respectto reproductive, developmental, neural, and immunesystems, as well as cancer research and environmentaldisease epidemiology. Eligible candidates must be U.S.citizens, noncitizen nationals of the United States, orhave legal permanent status in the United States. Inaddition, a candidate must have a Ph.D., M.D., or com-parable doctoral degree at the time of appointment. Formore information, visit website: http://www.sph.umich.edu/ehs/ettg/index.html.Direct letters of in-quiry and application to e-mail: [email protected] or by postal mail to: Environmental ToxicologyTraining Program, Department of EnvironmentalHealth Sciences, 109 Observatory Street, Univer-sity of Michigan, Ann Arbor, MI 48109-2029.

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