ECOMPOSE: development of Executable COntent in Medicine using Proprietary

and Open Standards EngineeringDipartimento di Informatica,

Universita’ del Piemonte Orientale “Amedeo Avogadro”, Alessandria, Italy

• Possible partecipants (AIM group):

- Paolo Terenziani (Full Professor)

- Laura Giordano (Professor)

- Stefania Montani (Researcher)

- Luca Anselma (Univ. Torino, Researcher)

- Alessio Bottrighi (Dr., PhD)

- …. ??

Previous & current work of the group

Starting from 1997, GLARE project, with Az. Ospedaliera S. Giovanni Battista in Turin

GLARE (Guideline Acquisition, Representation, Execution)

- domain-independent (e.g. bladder cancer, ischemic stroke)

- “physician-oriented” formalism

- Advanced AI techiques (only prototypes)

Previous & current work of the group

(1) TEMPORAL CONSTRAINTS (IN CLINICAL GUIDELINES)

- Representation formalisms

- Constraint propagation algorithms (e.g., to check consistency)

- Computational complexity vs expressiveness trade-off

- Methodology: a domain-independent module coping with time, to be loosely coupled with different systems

GL System_1

Temporal Module

GL System_n

Previous & current work of the group

(2) VERIFICATION OF CLINICAL GUIDELINES THROUGH MODEL-CHECKING

- Goal: a general-purpose approach to verify (any!?) property about any guideline in GLARE

- Which properties? (consistency, reachability of actions,…)

- Methodology: pairing GLARE with a model-checker (SPIN)

Translator GLARESPIN

GL1

GLn

….

GL1

GLn

….

P1 Pk….

Previous & current work of the group

(3) RESOURCE-BASED CONTEXTUALIZATION OF CLINICAL GUIDELINES

- Each GL action must specify required resources (instruments)

- Each specific hospital has a set of available resources

- Pruning away (paths of) actions which are not locally executable (due to lack of resources)

Previous & current work of the group

(3) RESOURCE-BASED CONTEXTUALIZATION OF CLINICAL GUIDELINES

- Each GL action must specify required resources (instruments)

- Each specific hospital has a set of available resources

- Pruning away (paths of) actions which are not locally executable (due to lack of resources)

Previous & current work of the group

(3) RESOURCE-BASED CONTEXTUALIZATION OF CLINICAL GUIDELINES

- Each GL action must specify required resources (instruments)

- Each specific hospital has a set of available resources

- Pruning away (paths of) actions which are not locally executable (due to lack of resources)

Previous & current work of the group

(3) RESOURCE-BASED CONTEXTUALIZATION OF CLINICAL GUIDELINES

- Each GL action must specify required resources (instruments)

- Each specific hospital has a set of available resources

- Pruning away (paths of) actions which are not locally executable (due to lack of resources)

Previous & current work of the group(not directly related to Medical

Informatics)

(4) Temporal extensions to (the semantics of) Relational Databases

(5) (Semantics of) cooperative updates to Relational Temporal Databases

(6) Ontology: modeling time and causation

LINKS to Workpackages

WP1, reviews

(a) Languages. We may contribute to the survey about languages representing guidelines (with specific attention to the treatment of temporal aspects)

LINKS to Workpackages

WP2, Standard developments

(b) Languages for clinical guidelines (with specific reference to temporal constraints).

(c) An “upper-level” for the ontology of clinical actions (IF ANY!?)

(d) Modelling the semantics of clinical guidelines (mapping into model-checkers’ languages; also temporal logics).

(e) Semantics of Relational Temporal Databases (IF USED!?)

LINKS to Workpackages

WP3, Life-cycles, and life-cycle support

(f) Semantics of cooperative updates on Temporal Relational Databases (IF USED!?)

(g) Resource-based contextualization

LINKS to Workpackages

WP4, Software tools

(h) task-specific prototypical tool to represent and propagate temporal constraints in clinical guidelines

(i) Prototypical tool for validation based on model-checking techniques (IF VALIDATION INCLUDED !?)

(j) Prototypical tool to contextualise guidelines on the basis of locally available resources.