postoperative pain management, eras, focus on …...postoperative pain management, eras, focus on...
TRANSCRIPT
Postoperative Pain Management, ERAS,
Focus on Policies and Protocols
ARAKESHISIHAN,MD,FACS
16thAnnualCME&CDEMeetingLasVegas,Nevada
May2019
Disclaimer
NoFinancialRelationshiptoDisclose
• EnhancedRecoveryAfterSurgery(ERAS)andPostoperativePainManagement.
• MultimodalAnalgesiaforPostoperativePain.Risks,Safety,andEfficacy,ReducingCostsandLOS.
• ReviewofAmericanPainSocietyPostoperativePain
Objective(1)
•ERASSociety,ObjectivePatientCentered•http://erassociety.org•http://erasusa.org•RegionalPartners•DifferenceDisciplines•Multimodal,Multidisciplinary•“EvidenceBasedMedicine”
•OutcomesDriven•BasedonData
ERAS-EvolutionEnhancedRecoveryAfterSurgery
• 1990’sProfessorHenrikKehlet–UniversityofCopenhagen(Denmark)Conceptofmultimodalsurgicalcare
• 2001KenFearonandOlleLjungqvistmetinLondonatanutritionsymposiaanddecidedtostartacollaborativegrouponperi-operativecare
• 2001-2002ERASStudyGroup• 2003FirstERASSymposiaStockholm• 2005Fearonetal.ClinNutrStudyGroupdevelopedandpublishedanevidence-
basedconsensusprotocolforpatientsundergoingcolonicsurgery• 2007Maessenetal.BrJSurg2007Concludedthatjustaddingaprotocolwasnot
sufficienttochangepracticetoERAS• 2010TheERASSocietywasofficiallyregisteredasanon-profitmedicalsociety
basedinStockholm,Sweden• 2016USAchapterhelditsfoundingmeetinginWashingtonDC• ERASProtocolindifferentdevelopmentalstagesfordifferentdisciplines
ERAS-History
OverviewBestoutcomeneedtolookatallvariables
ERAS
• SimilartotheconceptofCareplan• Improvingpatientcarebyreducing• Postoperativecomplications(infections)• Patientpainanddiscomfort(narcotics)• Shorteninghospitalstays(cost)
• UseoftheERASshownto: • Reducecaretime30% • Reducepostoperativecomplications50%
• Colorectal,Thoracic
ERAS
• Pre/Intra/PostinGYN-ONCsurgery• GIsurgery• Gastrectomy• RadicalCystectomy• Pancreaticoduodenectomy• ElectiveColonic,pelvic,RectalSurgery• BariatricSurgery• LiverSurgery• HeadandNeckSurgery• Esophagectomy• LungSurgery
Guidlinesfor
•ThekeyelementsofERASinclude:•Patient/familyeducation•Patientoptimizationpriortoadmission-Expectations•Pain,functionalstatus
•Minimalfasting-liquidsthemorningofsurgery•Multimodalanalgesia,useofopioidswhenindicated•Return-normaldietandactivitiesthedayofsurgery•Returntohome
Components
Akimuret.alSurgeryforObesityandRelatedDiseases14(2018)1850–1856
Example-ERAS
GoalToBeAccomplished
IfYouHaveEverWondered
• EnhancedRecoveryAfterSurgery(ERAS)andPostoperativePainManagement.
• MultimodalAnalgesiaforPostoperativePain-Risks,Safety,andEfficacy,ReducingCostsandLOS.
• ReviewofAmericanPainSocietyPostoperativePain
Objective(2)
WhatDoINeedToKnow?
•Definitions•Painassessment•Typesofanalgesics
•Theiraction•Sideeffects
Pain
“Painisanunpleasantsensoryandemotionalexperienceassociatedwithactualorpotentialtissuedamage…”
IASP(InternationalAssociationfortheStudyofPain)
• Isaprotectivemechanism
• Causesavoidance• Littletonotissueinjury• Painstopsoncethestimulusisremoved• Inflammationoccursinthearea• Nervedamage• Persistsafterthestimulusisremovedifchronic
Pain
•PossibleSelfCreatedProblem•Almostanythingwedoinvolvespain
•Comewithit,willhaveit,livewithit•Realistic,Honest,specific
WorldJGastroenterol.2003Apr15;9(4):847–850.OperativestressresponseandenergymetabolismafterlaparoscopiccholecystectomycomparedtoopensurgeryKaiLuo,Jie-ShouLi,Ling-TangLi,Kei-HuiWang,andJing-MeiShun
LangenbecksArchSurg.2017Nov;402(7):1023-1037.Systemicinflammatoryresponseafterherniarepair:asystematicreview.KokotovicD1,BurcharthJ2,HelgstrandF2,GögenurI2.
PatientExpectation
• Pain≠Nociception• Paininthebrain-perception• Nociception-peripheral-Visceralnervestimulation
• Fourstagesofprocessingpain:• Transduction
• Blockedbylocalanesthetics,NSAIDprostaglandins(Inflammation)• Transmission
• Preventedbylocalanestheticsperipheralnerves,nerveplexus,epiduralorsubarachnoidspaces
• Modulation• Localanesthetics&Gabapentin
• Perception• Generalanesthetics&Opioids
Pain&PainControl
Analgesics
Classesbasedonmodeofaction•Opioids•Non-steroidalanti-inflammatorydrugs•Localanesthetics•Miscellaneousdrugs•IVTylenol,Antidepressants,Anxiolytic
Pain&PainControl
Transduction Transmission Modulation Perception
Localanesthetics(topical)
Localanesthetics(regionalanesthesia)
Opioids Opioids
NSAIDs,Cox2inhibitors
Opioids Acetaminophen NMDArantagonists
Opioids Alpha2-agonists Cox2inhibitors Generalanestheticagents
Antihistamines Gabapentinoids SNRIs Acetaminophen
Capsaicin NMDArantagonists
NMDArantagonists
KehletH,DahlJB.(1993(Thevalueof‘‘multimodal’’or‘‘balancedanalgesia’’inpostoperativepaintreatment.AnesthAnalg.77:1048-56)
• Bind to opioid receptor sites within CNS (mostly µ but also κ)
• Are agonists, partial agonists or mixed agonists-antagonists
• Are controlled DEA • Reminder - Prescription Pads
Opioids
Opioids-SideEffects
OrganSystem SideEffects Intervention
CNS Drowsiness,DeliriumRespiratoryfailure
EarlyinterventionDeath
GI Nausea,Constipation longterm
CV Hypotension,Tachycardia,
orthostatichypo.
Treatsymptoms
Theultimategoalistodecreasedose,andalwaysconsideralternative.WhatistheExitstrategy?
NSAIDs
• NSAIDs organic acids • Anti-inflammatory, analgesic, and antipyretic • Inhibit prostaglandin production by inhibiting COX
enzymes
NSAIDs-SideEffectsOrganSystemSideEffect
• Na+ permeability neurons • Classified by duration of action
•Lidocaine is short acting with a rapid on-set
•Bupivicaine is long acting with a slow on-set
•Epinephrine
LocalAnesthetics
LocalAnesthetics-SideEffects
*4mg/kgIBW
Whymultimodalapproach?
KehletH,DahlJB:Thevalueof“multimodal”or“balancedanalgesia”inpost-operativepaintreatment.AnesthAnalg1993;77:1048–56
• optimizespainrelief• reducesideeffectburden• providesynergistic/additiveeffects• lowerdosesofeachmedicationneeded• opioidsparingpaincontrol• preventscentralsensitization
➢ Nonpharmacologic➢ Acetaminophen➢ NSAIDs➢ Adjuvants➢ RegionalAnesthesia
MaintainandOf
OpioidsOpioid
OptimizedProtocol
Manworren,R.C.E.(2015).Multimodalpainmanagementandthefutureofapersonalizedmedicineapproachtopain.AORNJournal101(3),308-314
Plan
• DifferentDisciplineofhealthcareproviders-RN,NP,MD
• Acutepainandchronicpain• Comfortlevelforcertain
meds• Plan
• Whatisnext?
• EnhancedRecoveryAfterSurgery(ERAS)andPostoperativePainManagement.
• MultimodalAnalgesiaforPostoperativePain.Risks,Safety,andEfficacy,ReducingCostsandLOS.
• ReviewofAmericanPainSocietyPostoperativePain
Objective
AmericanPainSocietyManagmentOfPostoperativePain
AmericanPainSocietyManagmentOfPostoperativePain
• August2009toJanuary2011• APS,ASA,and23memberswithexpertiseinanesthesia,painmedicine,surgery,obstetricsandgynecology,pediatrics,hospitalmedicine,nursing,primarycare,physicaltherapy
• Systematicreviewoftheevidenceonpostoperativepainmanagement
• GradingofRecommendations,Assessment,Development,andEvaluation
• Evaluatedallvariables,(procedure,discipline,patientAcuity,medicationHx.etc.
StrengthOfData-GRADE
“Ingeneral,astrongrecommendationisonthebasisofthepanel’sassessmentthatthepotentialbenefitsoffollowingtherecommendationclearlyoutweighpotentialharmsandburdens.Inlightoftheavailableevidence,mostcliniciansandpatientswouldchoosetofollowastrongrecommendation.Aweakrecommendationisonthebasisofthepanel’sassessmentthatbenefitsoffollowingtherecommendationoutweighpotentialharmsandburdens,butthebalanceofbenefitstoharmsorburdensissmallerorevidenceisweaker.Decisionstofollowaweakrecommendationcouldvarydependingonspecificclinicalcircumstancesorpatientpreferencesandvalues.Forgradingthequalityofabodyofevidencethatsupportsarecommendation,weconsideredthetype,number,size,andqualityofstudies;strengthofassociationsoreffects;andconsistencyofresultsamongstudies.
StrengthOfData
QualityofEvidence StrengthofRecommenda>on
BenefitsDoorDoNotClearlyOutweighRisks
BenefitsandRisksandBurdensareFinelyBalanced
High Strong Weak
Moderate Strong Weak
Low Strong Weak
Insufficientevidencetodeterminenetbenefitsor
harmsI
*FromthesystemdevelopedbytheGradingofRecommendaions,Assessment,Development,andEvaluaion(GRADE)workgroupandadaptedbytheAmericanPain
Society
Chou,R.,etal.(2016)Guidelinesonthemanagementofpostoperativepain.TheJournalofPain17(2).131-157
GuidelinesMultimodalAnalgesiaRecommendation Summary StrengthofData
1-2 EducatepatientEducationforParentofadultcaregiver
Strongrec.LowqualityStrongrec.Lowquality
3 EvaluateforpsychiatricCo-morbidities,substanceabuse Strongrec.Lowquality
4-6LowestDose
TreatproblemathandChildren(Dosing)
Strongrec.LowqualityStrongrec.LowqualityStrongrec.Highquality
7-8 TENSunitsAcupuncture,massagecoldtherapy
Weakrec.ModeratequalityNoposition
9-14
BehaviormodificationOralVIVAvoidIM
PCA(noBasal)#13,monitor#14
Weakrec.ModeratequalityStrongrec.ModeratequalityStrongrec.ModeratequalityStrongrec.Moderatequality
15-20(32)
AcetaminophenandNSAIDPreoperativedosing
Gabapentin(singledose)#17Katamine#18
LocalLidocaine(openandlap)#19,20
Strongrec.HighqualityStrongrec.ModeratequalityStrongrec.ModeratequalityWeakrec.ModeratequalityWeakrec.Moderatequality
Chou,R.,etal.(2016)Guidelinesonthemanagementofpostoperativepain.TheJournalofPain17(2).131-157
GuidelinesMultimodalAnalgesia
Chou,R.,etal.(2016)Guidelinesonthemanagementofpostoperativepain.TheJournalofPain17(2).131-157
GuidelinesMultimodalAnalgesia
Chou,R.,etal.(2016)Guidelinesonthemanagementofpostoperativepain.TheJournalofPain17(2).131-157
GuidelinesMultimodalAnalgesia
#26-32PainspecialistforinpatientPolicyandprocedureforfollowupThoraciccases-EpiduralPeripheralBlockandtopical
Strongrec.lowquality
Chou,R.,etal.(2016)Guidelinesonthemanagementofpostoperativepain.TheJournalofPain17(2).131-157
Summary
• ERAS• Itscomingtoyou-ifnottherealready-Careplan
• MultimodalAnalgesiaforPostoperativePain.Risks,Safety,andEfficacy,ReducingCostsandLOS.
• Utilizealltools,Educate,tameexpectation• ReviewofAmericanPainSocietyPostoperativePain• Alreadyinplaceindifferentforms
Thank you
ArmenianAmericanMedicalSocietyCMEcommittee
fortheopportunityprovided
Questions?