potassium channel structure the subunit is formed from 6 transmembrane segments and is associated...

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Page 1: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 2: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 3: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 4: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 5: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits

Potassium Channel Structure

The subunit is formed from 6 transmembrane segments and is associated with a regulatory subunit.

Four subunits form the pore.

Page 6: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 7: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits

Gli ioni K+, idrati in soluzione, perdono le molecole di H2O quando passano attraverso il filtro di selettività e formano dei legami di coordinazione con quattro O di gruppi carbonilici.

Gli ioni Na+, essendo più piccoli, non possono coordinarsi perfettamente con questi O e quindi attraversano il canale solo raramente.

Page 8: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 9: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits

The four domains of the subunit form the pore within the membrane.

Sodium Channel Structure

Page 10: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 11: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 12: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 13: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 14: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 15: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 16: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 17: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits

proprietàdei

recettori

proprietàdella

membrana

Più perdurerà il segnale più facilmente si potrà sommare

Page 18: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits

C = Q/V

C = A/d

m = Cm x Rm

Page 19: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits

m = Cm x Rm

Page 20: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits
Page 21: Potassium Channel Structure The  subunit is formed from 6 transmembrane segments and is associated with a regulatory  subunit. Four  subunits