Center for Research and Development of Light-Activated Materials

Daniel Engebretson, Director

Light-Activated Research

Definition: Materials or Processes that are produced or enabled by

light

Fields: Energy – Solar, Hydrogen Photocatalysis – Environmental Remediation Detectors and Sensors – Environmental, Biomedical Bioadesives – Wound Healing, Drug Delivery

Goal: Create businesses and jobs based on our technology

Light-Activated Materials

Examples of Light-Activated Materials already in the Marketplace: Energy – solar powered calculators, watches,

etc. Photocatalysts – anti-fog glass, self-cleaning

glass, etc. Detectors and Sensors – medical assays

(diagnostics), hazardous materials Healthcare

Bioadhesives – UV cure resins in dentistry Photodynamic Therapy – acne, cancer

Collaborators – Institutions

Senior Researchers

USD Chem/Physics Dan Engebretson Mary Berry James Hoefelmeyer Ranjit Koodali Stan May Grigoriy Sereda Yongchen Sun (Phys.) Andrew Sykes

USDSM Kaia Kloster (Avera) Gudiseva Chandrasekher

SDSU Chemistry Ron Utecht

Solar Energy – Opportunity

Photovoltaics, the direct conversion of sunlight to electricity, is the ONLY identified technology that can meet all four criteria: Affordable Reliable Secure Sustainable

AND satisfy WORLD electricity demand….

-Smalley and Lewis, IEEE PVSC Jan. 2005

Solar Energy

Teaming with

Researchers from SDSU and SDSMT

Problem – Much of the solar spectrum unused

2010 Solution – Design new molecules to “funnel” the solar spectrum

Photocatalysis – Opportunity

Rapidly Expanding Market

Opportunities in: Building Materials Air Purification Sterilization

Image Copyright PPG, Inc.

Photocatalysis

Problem – Most Applications Require Ultraviolet Light

2010 Solution – Design New Materials that Utilize Visible Light

Detectors and Sensors

In vitro diagnostics market >$20 billion in 2005

Nucleic Acid Testing to grow from $2.25 billion in 2004 to $6.5 billion in 2009

Nucleic Acid Testing, Navigant Consulting, 2004

Detectors – Opportunity

Problem – Most diagnostic tests require highly skilled technicians and specialized equipment

2010 Solution – Design and develop test kits that require minimal skills and common equipment

Bioadhesives – Opportunity

“In the next five to 10 years, surgical tissue ADHESIVES will be delivered which will REVOLUTIONIZE the art of surgery by replacing sutures in the majority of operations performed in the country… the age of commercially produced, effective surgical adhesives is now arriving in the US.”

-- Dr. William Spotnitz, Director of the Tissue Adhesive Center at the Virginia Health Sciences

Center, 2000

Bioadhesives

Problem – Current Bioadhesives are either toxic or weak

2010 Solution – Design new Bioadhesives that are Safe and Strong

Bioadhesives Research

Formulation Set for FDA Approval Identified New Variants

Ability to “Tune” Bond Strength Investigate Chemical Mechanisms

Understanding Applications Good Manufacturing Practices (GMP)

Essential for in vitro Studies

Bioadhesives – Applications

Ophthalmology LASIK Tethering Drugs

Dermatology General Surgery Cardiology Orthopedics

Commercial – PhotoBioMed

Licensed in South Dakota Biotech Company Incorporated in Texas Role: Identify Industry Partners Bioadhesives Research Conducted in SD Participated in World’s Best Technology

Competition in Dallas, TX Won Governor Round’s Giant Vision Business

Plan Competition PhotoBioMed CorporationTM: Strong and Safe Medical

AdhesivesTM

Outcomes – Jobs Created

*Daniel Engebretson, USD Chemistry Director CRDLM

*Gudiseva Chandrasekher, USDSM Ophthalmologic Applications of Bioadhesives

Ranjit Koodali, USD Chemistry Photoactivated Catalysis for Environmental Remediation

*James Hoefelmeyer, USD Chemistry. Catalytic Activity of Metal Nanoparticles

*Laura Koepsell, SDSU Chemistry 2004 USD Chemistry Graduate (B.S.) * New Position

Intellectual Property

Andrew Sykes – USD Chemistry Filed Disclosure on Luminescent Sensors for

Lead Detection Based on a Novel Photodynamic Mechanism

Kloster and Utecht – USDSM/Avera and SDSU Filed Disclosure on Alternative Chemical

Formulations for Tissue Bonding

Outcomes – Grant Activities

Eight Research Grants Awarded 3 Related to Energy 2 Related to Photocatalysis 1 Related to Photodynamic Cancer Therapy 2 Related to Undergraduate Research (Photodynamics

and Synthesis) 5 Different Principal Investigators Total value of awards nearly $3 Million Many others submitted and planned Teaming with 2010 Center for Accelerated

Applications at the Nanoscale for SD EPSCoR

Outcomes – NPURC

NSF – Northern Plains Undergraduate Research Center

7 Regional Colleges and Universities University of South Dakota (Vermillion, SD) Mount Marty College (Yankton, SD) Augustana College (Sioux Falls, SD) Sinte Gleska University (Rosebud Reservation, Mission,

SD) Fort Berthold Community College (Tribal College, New

Town, ND) Buena Vista University (Storm Lake, IA) Dordt College (Sioux Center, IA)

NPURC – Goals

Revise Curricula at Regional Schools Introduce students to research early in their academic

careers

Intensive Undergraduate Research Summer research experiences for undergraduates

Engage High School Science Teachers Better prepare high school students for college

Prepare Graduates to Participate in Tech-based Economy (Local or National) Graduates are resources rather than products

2010 and Beyond

Annual Revenue ~$2 Million 11 New Academic Jobs

1 New Faculty 10 New Postdoctoral Fellows/Research

Scientists 3 Small Businesses Started

Small Business Innovative Research 10-15 New Jobs

Royalty and License $ from Bioadhesives

South Dakota People

Dan Engebretson, Director

Kaia Kloster, USDSM/Avera

Laura Koepsell, SDSU Chemistry

CRDLM/Community

Help Develop Innovative Applications Sugar production Feedlots

Provide Conducive Atmospheres to Small Businesses Encourage citizenry to become “tech aware” Libraries and Schools