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Aipotu: a Computer Simulation Linking Genetics,
Biochemistry, Molecular Biology, and Evolution
Brian White
Biology Department
UMass Boston
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Goals of this talk
• Present Aipotu
• Recruit users – Education– Research?
• Feedback on design, model, etc.
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Outline
• Simulation Goals
• Description
• Sample Evolution Run
• Questions
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Connections
Genes
Proteins
LifeIndividual functions of living things
Genetics
Biochemistry
Molecular Biology
Evolution
The Phenomenon: Flower color
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Experiment: Select for Black
• Start with Green/Green
• Relative Fitnesses:– Black = 10 – White = 0– Other Colors = 1
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Select for Black Generation 0
Time (min:sec) 00:00
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Select for Black Generation 1
Time (min:sec) 00:16
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Select for Black Generation 2
Time (min:sec) 00:26
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Select for Black Generation 3
Time (min:sec) 00:42
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Select for Black Generation 4
Time (min:sec) 00:59
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Select for Black Generation 5
Time (min:sec) 01:09
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Select for Black Generation 6
Time (min:sec) 01:26
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Select for Black Generation 7
Time (min:sec) 01:38
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Select for Black Generation 8
Time (min:sec) 01:50
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Select for Black Generation 9
Time (min:sec) 01:58
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Select for Black Generation 10
Time (min:sec) 02:07
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Acknowledgements
• Ethan Bolker (CS)
• CS MS Students
• My Students
• John Jungck (BioQUEST)
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http://intro.bio.umb.edu/aipotu/[email protected]
• Questions?• My questions to you:
– How would you use this in teaching?– What features would you add?– How best to model evolution with it?– How do I know if this is ‘behaving properly’?– What other experiments should I do?