ppt penisilin
TRANSCRIPT
-
7/23/2019 PPT PENISILIN
1/22
PENISILIN
Nama Kelompok :1. DIFANDINI RIZKY FIRDAUS (
2. YOESHINTA MAYDINA (150!1"012"2#
-
7/23/2019 PPT PENISILIN
2/22
1. PENGERTIAN $e%&'&l&% me)paka% kelompok a%*&+&o*&ka ,e*a -ak*am a%/ *ela lama &ke%al.
$e%&'&l&% a*a) a%*&+&o*&k +e*alak*am aala kela' a%*&+&o*&k a%/ me)'ak&%&%/ 'el +ak*e& 'aa* +ak*e& 'ea%/ alam po'e' epo)k'&.
$aa *a)% 1324 & -o%o% Ale6a%e Flem&%/ me%em)ka% a%*&+&o*&ka pe*ama
a&*) $e%&'&l&% a%/ 'a*) ekae kem)&a% &kem+a%/ka% ole Floe a&
+&aka% $e%&7&ll&)m %o*a*)m )%*)k pe%//)%aa% '&'*em&k. Kem)&a% &/)%aka% $.
7'o/e%)m a%/ me%/a'&lka% $e%&'&l&% le+& +a%ak.
$e%&'&l&% a%/ &/)%aka% alam pe%/o+a*a% *e+a/& alam:
1. $e%&'&l&% alam
2. $e%&'&l&% 'em&'&%*e*&k
$e%&'&l&% 'em&'&%*e*&k &peole e%/a% 7aa me%/)+a '*)k*) k&m&a $e%&'&l&%
alam a*a) e%/a% 7aa '&%*e'&' a& &%*& $e%&'&l&%. ,e+eapa $e%&'&l&% aka% +ek)a%/ ak*&8&*a' m&ko+a%a alam ')a'a%a a'am
'e&%//a $e%&'&l&% kelompok &%& a)' &+e&ka% 'e7aa pae%*eal.
$e%&'&l&% la&% &la%/ ak*&8&*a'%a +&la &pe%/a)& e%&m ,e*alak*ama'e
($e%&'&l&%a'e# a%/ meme7a 7&%7&% ,e*alak*am.
-
7/23/2019 PPT PENISILIN
3/22
2. Mekanisme kerja
A%*&+&o*&ka ; lak*am I +ekeak*) pem+elaa% 'el 'e+a/&a% a& &%&%/
'el &%)k &l&'&' ole e%&m asetil muramidase.
E%&m transpeptidasea%/ &pel)ka% )%*)kpem+e%*)ka% &%&%/ 'el +a) &+lok& olepe%&'&l&% 'e&%//a pem+e%*)ka% &%&%/ 'el *&ak'emp)%a 'e&%//a +ak*e& ma*&.
-
7/23/2019 PPT PENISILIN
4/22
3. Farmakokinetik
Absorpsi:
?$e%&'&l&% @ *&ak *aa% *eaap ')a'a%a a'am (pH 2#. a&a% lam+)%/ (pH !# *&ak *elal) me)'ak.
@aam Na $e%&'&l&% @ oal &a+'op'& & )oe%)m.
Aa%a maka%a% aka% me%/am+a* a+'op'&.
Kaa mak' alam aa *e7apa& alam 0"0 me%&*. $em+e&a% &.m kaa mak' alam aa 150 me%&*.
?$e%&'&l&% B >ala)p)% ela*&= *aa% a'am 0C me%/alam& peme7aa%& +a/&a% a*a' 'al)a% 7e%a 'e&%//a *&ak 'empa* &a+'op'&
?Amp&'&l&% a+'op'&%a *e/a%*)%/ aa *&ak%a maka%a%.
Aa%a maka%a% alam 'al)a% 7e%a me%/am+a* a+'op'&.
?Amok'&'&l&% a+'op'&%a & 'al)a% 7e%a
-
7/23/2019 PPT PENISILIN
5/22
4. Distribsi
$e%&'&l&% @ &&'*&+)'& l)a' alam *)+)
-
7/23/2019 PPT PENISILIN
6/22
Jenis Pemberia
n
Dosis Bioavilibilita
s
Kadar T1/2
Penisilin G i.m 300.000
IU
- 8 g 30
Penisilin V Oral - 49% -
Ampisilin Oral 0,5 g 49% 3 60-90
Amosisilin Oral 0,5 g 65-!8% 6 60-90
"ar#enisilin i.m $ g - $5-0 60
!. "arakteristik Farmakokinetik
Penisi#in
-
7/23/2019 PPT PENISILIN
7/22
$. E%ek sampin& &o#on&an
penisi#in ? Reak'& ale/&'e&%/ &*&m+)lka% olepem+e&a% pe%&'&l&% k)')'%a pe%&'&l&% @.
,&'a *e
-
7/23/2019 PPT PENISILIN
8/22
Penisi#in G
$e%&'&l&% @ me)paka% pe%&'&l&% alam a& +&aka%P.Chrysogenum.D&pea/a%/a% 'e+a/a& a*
a%/ +e'&=a* a'am. Dalam la)*a% apa* *e)a&paa pH 5 a% G4 a% & *empa* &%/&%.
$e%&'&l&% ak*&= *eaap : Ne&''e&a /o%ooeae Ne&''e&a me%&%/&*&e' o%e+e7*e&)m &=*e&ae ,a7&ll)' a%*a7&'
-ep*o*&7&a +)77al&' S*aplo7o77)' a)e)' e'&'*e% *eaap +e%l
pe%&'&l&%. @o%o7o77)' me%)%
-
7/23/2019 PPT PENISILIN
9/22
-
7/23/2019 PPT PENISILIN
10/22
In'ikasi:
$e%&'&l&% @ me)paka% o+a* p&l&a% )%*)kpe%ak&* :
&%=ek'& k)l&*
&%=ek'& pe%a=a'a% 'e7aa &.8
&%=ek'& e%oka&*&' paa
-
7/23/2019 PPT PENISILIN
11/22
S&=&l&' p&me 'ek)%e a% la*e% k)a%/ a& 1
*a)% a)' &o+a*& e%/a% o'&' *)%//al 2!
-
7/23/2019 PPT PENISILIN
12/22
"ontrain'ikasi:
$em+e&a% oal me)paka% ko%*a&%&ka'& paa pe%ak&* +ea* kae%a
kaa pe%&'&l&% alam aa e%a.
H&pe'e%'&*&8&*a' *eaap pe%&'&l&% me)paka% ko%*a&%&ka'& )%*)k
pemaka&a%%a.
-
7/23/2019 PPT PENISILIN
13/22
Penisi#in (
Spek*)m a%*&m&ko+a 'ama e%/a% pe%&'&l&% @ a&*) *eaap
+ak*e& /am po'&*= aeo+ k)a%/ e=ek*&= *eaap +ak*e& /am%e/a*&=.
Re'&'*e%'& *eaap pe%&'&l&% B 'e)pa e%/a% e'&'*e%'& *eaappe%&'&l&% @.
In'ikasi:
$e%&'&l&% B me)paka% o+a* p&l&a% )%*)k )*e oal &+a%&%/ka%pe%&'&l&% @ kae%a '*a+&l alam a'am lam+)%/ *e)*ama )%*)k
pe%/o+a*a%:
&%=ek'& '*ep*o7o77' po/e%e' paa =a&%/&*&'
Kolea
Demam ema*&k
E%oka&*&'
I%=ek'& 'al)a% pe%a=a'a%
I%=ek'& k)l&* a% m)ko'a.
-
7/23/2019 PPT PENISILIN
14/22
"ontrain'ikasi:
$e%&'&l&% B *&ak apa* &+e&ka% paa &%=ek'& +ea*kae%a ko%'e%*a'& alam pla'ma e%a.
E%ek sampin&:
H&pe'e%'&*&8&*a' l&a 'epe*& &*)m+)&
-
7/23/2019 PPT PENISILIN
15/22
Amoksisi#in
Amok'&'&l&% memp)%a& 'pek*)m a%*&+&o*&kaa%/ &e%*&k e%/a% amp&'&l&% ke7)al&amok'&'&l&% peka *eaap e%&m pe%&'&l&%a'e.
Resistensi:
M&ko+a a%/ e'&'*e% *eaap amok'&'&l&%aala +ak*e& a%/ mempo)k'& e%&mpe%&'&l&%a'e a&*): Enterobacterpylori,Peudomonas aureus, Clostridium tetani.
E%ek sampin&: M)al M)%*a emam D&ae Kelemaa%
&pe'e%'&*&8&*a' /a*al/a*al.
-
7/23/2019 PPT PENISILIN
16/22
-
7/23/2019 PPT PENISILIN
17/22
In'ikasi:
U%*)k me%/o+a*& pe%ak&* :
&%=ek'& paa k)l&*
&%=ek'&
-
7/23/2019 PPT PENISILIN
18/22
Ampisi#in
Spek*)m ke
-
7/23/2019 PPT PENISILIN
19/22
-
7/23/2019 PPT PENISILIN
20/22
In'ikasi:
U%*)k &%=ek'& 'al)a% )&% m&': p&elo%e=&*&' k% E.7ol&.
I%=ek'& @o%ooe I%=ek'& 'al)a% pe%a=a'a% ole '*ep*o7o77)'
p%e)mo%&a
S&%)'&*&'
O*&*&' me&a I%=ek'& 'al)a% empe).
)e'iaan
$em+e&a% oal alam +e%*)k *a+le* a*a) kap')l 'e+a/a&
amp&'&l&% *&&a* 125 m/ 250 m/. 500 m/ a% 1000m/. ,e%*)k ')'pe%'& me%/a%)%/ 125 m/ a% 500m/5ml. Amp&'&l&% apa* +e+e%*)k ')%*&ka%.
Do'&' e>a'a )%*)k &%=ek'& &%/a% 'ampa& 'ea%/ 2! /'ea& &+a/& ! kal& &+e&ka% 'e+el)m maka% U%*)k
&%=ek'& +ea* &+e&ka% 'e&aa% pae%*eal !5 / 'ea&.
-
7/23/2019 PPT PENISILIN
21/22
Kombinasi:
Kom+&%a'& pe%&'&l&% &mak')ka% )%*)kme%apa*ka% ke
-
7/23/2019 PPT PENISILIN
22/22
Interaksi Penisi#in 'en&an *bat #ain
Kombinasi Interaksi
Penisilin&"loram'eniol,eri(romisin, (e(rasilin
A) #a(erisi*a (i*a #ole+ *iom#inasi *g#a(erios(a(ia rn #a(erios(a(ia
mengin+i#isi A) #a(erisi*aPenisilin V&eomisin eomisin Oral aan mengrangi a#sorpsi
penisilin V
"ar#enisilin&Gen(amisin )ila *i#erian #ersama-sama aanmenrnan a*ar gen(amisin *alam *ara+
Ampisilin&Aloprinol en/e#e#an malopaplar ras+
Amosisilin&As."lalina(
en/e#a#an mal *an mn(a+