preliminary clinical results of adipose derived stem cell injection for
TRANSCRIPT
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Preliminary clinical results of adipose derived stem cell injection
for facet joint syndrome
Ralf D. Rothoerl 1,2, Christopher Alt 2, Alexander Preuss1, Christopher Muller3,
Peter Lackermeier3
1 Department for Neurosurgery, 2 Center for Regenerative Medicine and Sports Medicine 3 Department of Anesthesia
Isarklinikum Munich, Germany,
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• 70 % suffer from chronic low back pain
• 50 % of days of sick leave are due to back pain
• Facet joint syndrome is a common cause
Facet joint syndrome
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Facetten
Facet joint syndrome
• Degenerative disease
• Athrosis of the spinal joints
• Inflammatory activation
Athrosis
chronic inflammation
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• Cortisol injections
• Physiotherapy
• NSAR
• Radiofrequency
• Treatment response 50-70 %
Weber et al 2015
Standard treatment
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Immunsuppressive effect of ADSCs
W Nathaniel Brennen et al.
Endocr Relat Cancer
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approx. 20min 45 min 15 min
Treatment process
Liposuction Separation Injection
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InGeneron
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• VAS 7-8 back pain
• No radiating pain
• Cortisol injections temporaryeffect
• SVF LWK 4/5 und 5/SWK1
Case Report
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• VAS 1 back pain
• 30 months Follow-up
Back pain
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• 19 male patients
• age range 31-78 years, mean 59
• Duration of symptoms > 1 year
• Positive test injection (Ropivacain)
75% pain relief
• Liposuction (mild sedation)
Material and methods
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• Injection facet joints under fluoroscopic guidance
• VAS
• Oswestry Disability index
• Follow–up > 1 year
• Side effects
Materialis and methods
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Pain relief after 48 hours
VAS 7.2 mean vs. VAS 1,8 mean postoperatively
ODI 74,3% vs. ODI 19,1%
Folllow-up13,2 months
Longest follow-up16 months.
Results
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Results
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ODI mean prä ODI mean post
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VAS mean prä VAS mean post
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• SVF may be used for regulating inflammatory responses in degenerative diseases of the musculoskeletal system characterized by chronic inflammation
• No side effects
• No long term data
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Conclusions
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