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  • 8/19/2019 Prenatal Screening Revisi

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    DAIGNOSIS PRENATAL

    Irene, Rani, Rudy, Nevin, Ritsia, Abram, Hendrik, Mirna, Prisilla,

    Fanny

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    DIAGNOSIS PRENATAL

    TUJUAN :

    A. Deteksi aal kelainan k!n"enital

     

    #. Deteksi "an""uan kese$a%teraan

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    A. Deteksi Cacat Bawaan

     INDI&A'I P(M(RI&'AAN : ). Fakt!r risik! * +redis+!sisi

    yan" da+at dikenal sebelum

    ke%amilan :  Umur ibu  - t%  Parental /!nsan"uinity 

     &el!m+!k etnis tertentu Riayat keluar"a yan" buruk   Riayat !bstetri yan"

    buruk 

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    3. Fakt!r risik! yan" da+at

    dikenal dalam ke%amilan :

     &elainan "ambaran U'4

     &elainan kadar AFP

     P!li%idramni!n  0li"!%idramni!n

     In5eksi ibu

     &!ntak * makan !bat1 !bat dan 6at kimia terat!"enik 

     Radiasi

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    METODE PEMERIKSAAN

    I. Pemeriksaan serum 2 urine ibu :

     Tri+le test : kadar dalam serum

      AFP   %74

      (stri!l

     Asam metilmal!nat

    met%ylmal!ni/ a/iduria

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    II. Pemeriksaan $anin in uter! :

    ). U'4 8 Ultras!n!"ra9

    3. Fet!sk!+i

    -. Radi!l!"i

    . MRI 8 Ma"neti/ Res!nan/e Im

    . (mbri!sk!+i

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    III. Pemeriksaan sel*$arin"an

     $anin :

      ; Fetal Tissue 'am+lin" <

    ). Teknik invasi5 

     Amni!sentesis  As+irasi dara% $anin ;F#' 8 Fetal bl!!d

    sam+lin"

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     AMNIOSENTESIS

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    CHORIONIC VILLUS SAMPLING

     Villu

    s

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    CHORDOCYNTHESIS

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    3. Teknik n!n invasi5 

     Preim+lantati!n "eneti/

    dia"n!sis

     Maternal bl!!d sam+lin"

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    Pemeriksaan Laboratorium

     Analisis kr!m!s!m

     Analisis DNA

     Analisis #i!kimia

     Analisis Hemat!l!"i

     Analisis Mikr!bi!l!"i  Dll

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    TEKNIK PEMERIKS N

    KROMOSOM : FISH ( Fluorescence In Situ Hybridization )

    DNA :* !R ( oly"erase !#ain Reaction)

      * Sout#ern blot

      * ulsed $eld %el electrooresis

     "RNA : * Not#ern blot   * Rnase A "a&&in%

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    B. Evaluasi Kesejahteraan Janin

     ). 'e/ara &linis :  Pen"ukuran tin""i 5undus

    uteri 2 lin"karan +erut ibu

     Pen"ukuran +ertamba%an ## ibu

     (valuasi #unyi Jantun" Janin

    ;#JJ<

     Pemantauan "erakan $anin

     ; Fetal &i/k 7!unt : N!rmal  )> *

    )3 $am <

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    3. 'e/ara #i!kimia :

    Pemantauan kadar :  H!rm!n estri!l

     HP? 8 Human +la/ental

    la/t!"en  7%!ri!ni/ "!nad!tr!+in

     ?*' rati! ;?e/it%ine*'+%yn"!myelin <

     +H dara% $anin

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    -. 'e/ara (lektr!nis :

    7T4 8 7ardi!t!/!"ra+%y U'4 termasuk D!++ler U'4

    Pemantauan #i!9sik Janin

     (&4 $anin

     ((4 $anin

     FP0 ;Fetal +ulse [email protected]<

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    KARDIO TOKO GRAFI

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