prep & industrial scale - chemsupplythe system ns 4101 comprises of a chromatography pump (flow...
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Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
1 Vers. 01122012
Prep & Industrial Scale
Chromatography
systems
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
2 Vers. 01122012
Prep- to Industrial Process
Chromatography is about producing
compounds at the highest yield,
lowest costs and required purity!
“Consensus™” stands for achieving
this objective!
Chromatography is considered by many people an exotic purification / separation
technology. They would use chromatography only if re-crystallization or distillation is
unsuitable. We are growing into an era where active ingredients or excipients are
produced for smaller markets or don’t crystallise. Many new molecules are highly active
and produced in small quantities. New ways in chromatography will revolutionize the
pharmaceutical, biotech and fine chemical industry!
We are a group of independent and innovative chromatography pioneers that have built
through the years our own enterprises that specialise in developing and manufacturing
unique particles, mechanical and software tools including processes. Pooling all our
skills and knowledge we move chromatography into new era - we convert
chromatography into the most competitive of all purification methods. With our
accumulated skill power we help you to manufacture the most competitive
compounds!
We offer
1. Very competitive Turn-Key Chromatography Plants
2. Advanced Process-Know-How
3. Novel Process Components to advance your current plant (Pumps, Detectors,
new or very competitive phases with unique properties etc.)
Check us out - we will surprise you!
Please send us answers to the questions in the attachment.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
3 Vers. 01122012
NS4101 Unitary high pressure analytical HPLC system
Art. Nr. AS1001
The system NS 4101 comprises of a chromatography pump (Flow rate 10 ml/min)
combined with a uv to visible detector for isocratic runs for analysis and semi prep –
operations. It is a very stable system for routine analysis in a production lab. Sample
injection is via manual injection valve.
Column at your own choice
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
4 Vers. 01122012
NS4201 Binary high pressure analytic HPLC system
Art. Nr. AS20001
The System NS4201 is very competitive analytical binary system comprising of two
HPLC piston pumps and a UV – visible detector, a manual injection valve and static
mixer. For gradient and isocratic operation in a routine analytical lab operation.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
5 Vers. 01122012
NS 4205 Binary high pressure semi-preparative HPLC system
Art. Nr. AS 20005
The system NS 4205 is a binary semi-prep HPLC System with a constant flow 50 ml/
min flow rate. Sample injection is through a manual injection valve and a semi-prep static
mixer. The UV – visible detector has a semi prep –flow cell. It is ideal for gradient and
isocratic mode HPLC. It is ideal for process research and peptide purification
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
6 Vers. 01122012
The System LS 2010 is a preparative binary liquid phase purification-separation HPLC
plant with flow rate of 100 ml/ min. For 10 to 50 mm id pre-packed column. The system
is supplied with a 50 mm id Dynamic axial compressed column. The detector is a prep-
UV-visible detector.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
7 Vers. 01122012
The System PS 30030 is a ternary preparative separation purification system with flow
rates up to 300 ml/ min. The system utilizes either manual injection or injection through
ternary HPLC pump. The peaks are collected via a UV- visable detector . With the system
comes with a 80 mm id DAC column
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
8 Vers. 01122012
Ternary preparative liquid phase large scale separation and
purification system
Art. Nr. PS30060.10
Performance Characteristics
Ternary preparative high pressure purification and separation system with excellent
price/performance ratio. Max. Flow rate is 600 ml/min. Injection is via ternary HPLC pump.
Large 20 ml injection loop. 100 mm id DAC Column.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
9 Vers. 01122012
Ternary preparative large scale liquid phase separation and purification
system
Art. Nr. PS 30100.15
Performance characteristics
Two large prep HPLC pumps (Flow rate: max. 1000 ml/ min) for isocratic and gradient
mode of operation. One prep sample injection pump, static mixer and UV – visible detector.
DAC column 150 mm id.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
10 Vers. 01122012
Ternary commercial scale preparative separation and purification
system
Art. Nr. CS 30300.20
Performance characteristic
Ternary industrial scale purification & separation system comprising of two large prep HPLC
pumps (Flow rate: max. 3000 ml/ min) for isocratic and gradient mode of operation. One prep
sample injection pump, static mixer and UV – visible detector. DAC column 200 mm id.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
11 Vers. 01122012
Commercial scale prep preparative liquid phase chromatographic
separation and purification system
Large production scale system comprising of HPLC pumps for solvent infusion, slurry
mixing, sample injection. The process includes also DAC column ranging from 150 mm to
2000 mm id, a detection system, process- and data control and fraction collection. For
large flow rates e.g. 10, 20, 40, 80 and 120 l / min) special diaphragm pumps are being
used
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
12 Vers. 01122012
Surface Quality of DAC column
Column Material: SUS316L,
Inner walls: electropolished
Surface quality:
For ID 50mm to 200mm DAC column: less than or equal to 0.1 micrometer
For > 200 mm ID DAC column: less than or equal to 0.2 micrometer
We offer special surfaces e.g. for bio-application or servere chemical
environments.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
13 Vers. 01122012
List of Datasheets for various components
Code
Category Product
EA Prep HPLC Systems EA001 NewStyle Unitary High Pressure Analytical Chromatography System 4101
EA010 NewStyle Binary High Pressure Analytical Chromatography System 4201
EA020 NewStyle Binary High Pressure Semi-Prep Chromatography System 4205
EA030 NewStyle Binary Separation & Purification System 2010 for Process Research
EA040 Newstyle Ternary Large Scale Preparative Separation and Purification System with 80 mm ID Column
EA050 Newstyle Ternary Large Scale Preparative Separation and Purification System with 100 mm ID Column
EA060 Newstyle Ternary Large Scale Preparative Separation and Purification System with 150 mm ID Column
EA070 Newstyle Ternary Large Scale Preparative Separation and Purification System with 200 mm ID Column
EA080 Industrial Scale Purification & Separation System with column id ranging from 150 mm up to 2000 mm
EB Flash and Medium Pressure Pumps
EB001 LCC Consensus Pump E100SS
EB010 LCC-Consensus Low Pressure Pump LP100
EC High Pressure Liquid Chromatography Pumps
EC001 LCC Consensus HPLC Pump R 200
EC010 LCC Consensus HPLC Pump R 300
EC020 LCC Consensus HPLC Pump R 400
EC030 Newstyle Analytical HPLC Pump NP7001 EC040 Newstyle Semi Prep HPLC Pump NP 7005C
EC050 Newstyle Semi Prep HPLC Pump NP 7010C EC060 Newstyle Prep HPLC Pump NP 7030C EC070 Newstyle Prep HPLC Pump NP 7060C
EC080 Newstyle Prep HPLC Pump NP 7100C EC090 Newstyle Prep HPLC Pump NP 7300C
ED Special Pumps ED001 Parallel Prep-Chromatography Pump with Ten Heads
ED002 LCC Consensus Valveless Metering Piston Pump MP 200
EE Detectors EE001 Fixed Wavelength Detector Flash 06S
EE010 UV-VIS Diode Array Detector FLAS 10 DAD 400
EE020 UV-VIS Diode Array Detector FLAS 10 DAD 800
EE030 UV Diode Array Detector DAD 600
EE040 UV Diode Array Detector DAD 600 with external Cell
EE050 Flow Cells.
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
14 Vers. 01122012
EF Fraction Collectors EF001 LCC Consensus Rotary Fraction Collector FC 80 EF002 LCC Consensus Fraction Collector XY-FC160 EF003 LCC Consensus XY-Fraction Collector FC 1000 EF010 LCC Spider Fraction Collector EF020 Consensus Modular Fraction Collection System CMFS 4000
EF021 Racks for 4000 Series
EG Sundry Equipment EG001 Multi Column Switch Units
EH Steel Columns EH001 Custom Packable Stainless Steel HPLC columns EH020 Custom Packable Prep Stainless Steel HPLC columns
EH040 Static Axially Compressed Stainless Steel & Glass Columns EH060 Dynamic Axially Compressed Stainless Steel Columns
EI Glass Columns EI001 Medium Pressure Liquid Chromatography Glass Columns. EI020 MPLC Column Components
EI040 Low Pressure Borosilicate Glass Columns EI050 Static Axially Compresses Glass Columns
EJ Plastic Cartridges EJ001 Consensus PE Flash Chromatography Cartridges
EJ030 Empty Flash Cartridges & Components
EK Glass Cartridges EK001 Glass cartridge complete, biocompatible, up to 35 bar
EL Manual Valves EL001 LCC Consensus Prep injection Valve B & D
EM Motor Driven Valves
EM001 LCC Consensus Low Pressure 3 Port Motor Valve
EM010 LCC Consensus Low Pressure 4 Port Motor Valve
EM020 LCC Consensus Low Pressure 6 Port Motor Valve EM030 LCC Consensus Low Pressure 6 Port Motor Valve 2
EM040 LCC Consensus Low Pressure 12 and 24 Port Motor Valve
EM100 LCC Consensus High Pressure 6 Port - 2 Position Motor Valve
EM110 LCC Consensus High Pressure 10 Port - 2 Position Motor Valve
EN Software
EO Sample Drying – Solvent Recycling
EP Professional Guidelines
Steinbruchstrasse 4, CH-4622 Egerkingen, Switzerland
Tel.: +41 (0)62 398 52 71, Fax: +41 (0)62 398 52 74
[email protected] , www.chromatographyshop.com
15 Vers. 01122012
Attachment 1
Fundamental Question in Prep Chromatography a. In which group belong your target compounds
1. Organic Synthetic Compounds with MW<2000 (Heterocycles, Vitamins, Organometallics, Hormones,
Pesticides)
2. Natural Products with MW <2000 (Saccarides, Lipides, Phospholipides, Isoprenoids, Steroids, Alkaloids,
Flavenoids, Terpenes, Polyphenols, Saponins, Proanthocyanidins, Tannins etc from a wide range of
matrixes)
3. Amino Acids, Peptides, Oligonucleotides
4. Large scale racemate purification
5. Inorganics Separation (Cations and Anions, Metals, Nobel Metals, Acids, Alkalis, Industrial
Waste,Hydrometallurgical- refining, leachages, extracts, precipitants)
6. Protein, Biomarkers and Biotherapeutic Proteins (Enzymes, Membrane Proteins, Recombinant Proteins,
Antibodies, extracts from mammalian Tissue, Erythrocytes, Yeast, Bacteria)
b. Sample preparation
1. In what condition is the compound supplied for chromatography processing?
2. Is sample preparation necessary?
3. What type of sample preparation?
c. Environmental factors
1. Does the compound have to be process in organic solvent or can it be done in aqueous systems?
2. Is ATEX configuration necessary?
3. Are there facilities for solvent recycling?
4. What shall happen with the by-products?
d. Process equipment selection
1. Anticipated Business volume (g, kg or tons per day/week or month of pure compound)?
2. Level of purity to be achieved?
3. Envisaged process life?
4. Envisaged process and maintenance costs
5. Envisaged capital cost?
6. Strategy to finance capital investment?
7. Separation materials to be used?
8. Has a phase evaluation been conducted to assure selection of the most effective material.
e. Preferred Process Mode
1. Single columns batch chromatography (Flash, MPLC, HPLC, Expanded Bed Purification, new experimental
processes)?
2. Parallel column chromatography?
3. Continuous column processes (SMB , SSR)?
4. New experimental processes?