preparation 1 000

7/28/2019 Preparation 1 000

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Liposomes

Lipid bilayers (consists of phospholipids

identical to cell membrane phospholipids)

surrounding an aqueous space.


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Liposomes


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Liposomes may be

A- Unilamellar consisting of phospholipids

bilayer enclosing aqueous layer

B-Multilamellar vesicles (MLV) consist of

several (up to 14) lipid layers (in an onion-

like arrangement) separated from oneanother by a layer of aqueous solution


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Unilamellar liposomes Multilamellar liposome


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Applications Release their contents when they reach a specific temperature.

Release their contents at a specific pH value.

Target certain tissues or cell types by changing the types oflipids in the liposome.

Target tissues, cell types or specific proteins by attachingantibodies to the surface.

Avoid certain tissues or cells by attaching complex sugars tothe surface.

Evenly distribute fat-soluble (oil-like) compounds such ascertain vitamins, antioxidants, antibiotics, flavors, etc. whichoften cant be mixed in water-based products including most

foods. Fuse with cells, which is important in delivering DNA to a cell.

Serve as model cell membranes making it easier to studyspecific cellular processes and how certain molecules, such as

drugs, interact with cells.


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Protect compounds from acidic and enzymaticdegradation in the stomach and intestine by usingcertain molecules to coat the liposome.

Protect compounds such as vitamins and antioxidantsfrom premature oxidation for increased shelf-life.

Enhance the intestinal absorption of compounds bycoating with certain molecules.

Carry drugs across the nasal mucosa (nasal drugdelivery).

Deliver drugs directly to lung tissue by inhalation of theliposomes.

Carry fluorescent dyes or other types of moleculeswhich allow the liposomes to be tracked in the systemto which they are added.

Dermatological uses


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Preparation of liposome micro-encapsulateddrugs

1-With cream, ointment and gelLiposomes added to cream ,ointment or gel and mixtill complete solubility occur

2- with tabletsa- Decoating of the tablet if it was sugar coated byphosphate buffer or salin or distilled water to preventmicro encapsulation of sugar particles by liposome

b- Grinding of the tablets

c- Add liposome to the tablet and mixing then leave for

3 hr (incubation period that allow micro-encapsulationof all the active ingredients in liposome)

d- Add cream, ointment or gel

N.B. liposome increase penetration capacity by 20 to 30

fold


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Dose

Ointment 5ml/ 10gm

Creams 7ml/ 10gmLotions 1- Alcoholic 10ml/100ml

2- aqueous 20 ml/100 ml

3- PEG 20 ml/100 ml4- PG 25 ml/100 ml


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1-Wound dressing preparation

Mephincol 2 capLiposome base 10 ml

Uses: After surgery and in 1st degree of burn

2-Preparation for 2nd and 3rd degree of burn

Mephincol 4 capVerapamil 80 mg 30 tab

Liposomal base 30 ml


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N.B

Verapamil is Ca-channel blocker can inhibitIL6 and increase collagenase enzyme

activity so its effective topically as anti-

inflammatory and fibrolytic drug


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(3)Preparation for 3rd degree of burning

Collagenase oint. 4 tubes

Verapamil 80 mg 30 tab

Liposomal base 30 ml

(4) Preparation for Scar and Keloid

A) 1st step (Till degradation of fibrous tissue

occur)

5-fluro uracil 4 amp

Liposome 20 ml


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B) 2nd step

5-fluro uracil 4 ampVerapamil 80 mg 20 tab

Liposome 20 ml


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5- Preparation for ulcer

Dinitra 5 mg 5 tabMetronidazol 250 mg 4 tab

Lignocaine 1 tube (if needed)

Liposome 30 mluses:

1- Bed sores

2- Leprometouse ulcer3- Diabetic foot


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6- Preparation for anal fissures

Glycerin.T.N 0.2 %

Liposome base 20 ml

Lignocaine 1 tube


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(7)Preparation for Acne

(a)

Salicylic. a 4 gm (keratolytic)Sulfur 6 gm (keratolytic with antibacterial)

Resorcinol 4 gm (anti bacterial and antifungal)

Zinc oxide 12 gmCalamine 8 gm

Glycerin 30 ml

Alcohol 70% 35 ml

Liposome base 35 ml


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(B)

Benzoyl peroxide 5%

Mephenicol 4 cap

Liposome base 20 ml

1- Used for cystic Acne

2- Benzoyl peroxide has dual action

a) turnover of epithelial cells

b) Decompose oxygen killing of Propionibacterium acne

(8) P ti f f l i f ti T i l


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(8) Preparation for fungal infection T.versicolor

A)

Clotrimazol.oint 20 gm

Liposome base 10 mlB)

Ciclopirox 1 %(batrafin) 3 bottle

Diprosalic lotion 1 bottle

Liposome base 15 ml

C)

Terbenafin (Lamisil) 20 gmLiposome base 10ml


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(9)Preparation for diffuse Alopecia

Minoxidil powder 2%

Liposome base 30 ml(10)Preparation for Skin aging

A) Male

Testosterone (Sustanon) 8 amp

Phenytoin 100 mg 5%Eudyna oint 10 gm

Liposome base 25 ml

B) FemaleEstrogen (Ovestin) 20 Tab

Phenytoin 100 mg 10 cap

Eudyna oint 10 gm

Liposome base 25 ml

preparation 1 000

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