presented by william tap at 2014 asco annual meeting
DESCRIPTION
A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS) . Presented By William Tap at 2014 ASCO Annual Meeting. Pigmented Villonodular Synovitis (PVNS)Tenosynovial Giant Cell Tumor (TGCT). - PowerPoint PPT PresentationTRANSCRIPT
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<br /> A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS)
Presented By William Tap at 2014 ASCO Annual Meeting
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Pigmented Villonodular Synovitis (PVNS)<br />Tenosynovial Giant Cell Tumor (TGCT)
Presented By William Tap at 2014 ASCO Annual Meeting
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Pigmented Villonodular Synovitis (PVNS)
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 4
Presented By William Tap at 2014 ASCO Annual Meeting
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Can we help patients (PVNS) <br />with a highly targeted therapy (PLX3397)<br />that blocks the CSF1R pathway <br />in this clonal neoplastic process frequently<br />initiated by a single genetic event?
Presented By William Tap at 2014 ASCO Annual Meeting
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Study Goals
Presented By William Tap at 2014 ASCO Annual Meeting
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Study Design
Presented By William Tap at 2014 ASCO Annual Meeting
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Efficacy Assessments
Presented By William Tap at 2014 ASCO Annual Meeting
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Tumor Volume Score (TVS)
Presented By William Tap at 2014 ASCO Annual Meeting
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Patient Disposition
Presented By William Tap at 2014 ASCO Annual Meeting
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Patient Characteristics: Safety Population (n=23)
Presented By William Tap at 2014 ASCO Annual Meeting
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Safety: PVNS Expansion Cohort AEs<br />n = 23 Safety Population
Presented By William Tap at 2014 ASCO Annual Meeting
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Treatment-Related AEs ≥ Grade 3
Presented By William Tap at 2014 ASCO Annual Meeting
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Duration of Treatment (DOT), April 2014 data cutoff:<br />Median 256 days (range 21-585 days)
Presented By William Tap at 2014 ASCO Annual Meeting
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14 patients evaluable with TVS
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 16
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 17
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 18
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 19
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 20
Presented By William Tap at 2014 ASCO Annual Meeting
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Slide 21
Presented By William Tap at 2014 ASCO Annual Meeting
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Conclusions
Presented By William Tap at 2014 ASCO Annual Meeting
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Thank You
Presented By William Tap at 2014 ASCO Annual Meeting