primary care medicine and ophthalmologyprimarycareinternalmedicine2018.com/uploads/1/2/2/... ·...
TRANSCRIPT
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Claudia U. Richter, M.D. Ophthalmic Consultants of Boston, Inc.
Ophthalmology in Primary Care 2019
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No financial disclosures
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Objectives
Red Flag Signs and Symptoms Red eye Nonvision threatening Vision threatening
Cataracts Glaucoma-What is new ARMD
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Red Flag Signs and Symptoms Require urgent referral Decreased vision Metamorphopsia (distorted vision) Severe eye pain Red eye with light sensitivity Corneal opacity Flashes and floaters Binocular double vision
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Nonvision Threatening Red Eye
Subconjunctival hemorrhage Stye/chalazion Blepharitis Conjunctivitis Dry eye
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Vision Threatening Red Eye
Corneal infections Iritis Angle-closure glaucoma
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Subconjunctival Hemorrhage
Bright red eye Normal vision No pain Usually no obvious
cause No treatment
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Stye/Chalazion
Stye (hordeolum): obstruction of the perifollicular glands Chalazion: obstruction of
the Meibomian glands
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Stye/Chalazion
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Stye/Chalazion
Treatment Warm compresses +/- topical antibiotics Systemic antibiotics for associated
preseptal cellulitis Incision and curettage for drainage
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Blepharitis Chronic inflammation
affecting the lash line Dysfunction of the
meibomian glands Secondary infection Associated with acne rosacea
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Blepharitis Symptoms
Foreign body sensation Burning Mattering of the lashes Eyelids sticking
together upon waking Chronic
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Blepharitis Treatment
Warm compresses Lubricant eye drops Mechanical cleansing of lids Omega-3 fatty acid supplements (flaxseed oil,
fish oil) Counseling that this may be a chronic or
recurring problem
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Blepharitis Treatment
Topical antibiotics Azasite (azithromycin in DuraSite) Topical steroids for inflammatory component
(only for short duration) Restasis (off label) Systemic doxycycline for refractory problems Lipiflow
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Diagnosis of Conjunctivitis
Stringy white mucus: allergic Purulent discharge: bacterial Watery: viral
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Allergic Conjunctivitis
Symptoms: ITCHING Clinical findings Normal exam Lid or conjunctival
edema Stringy white
discharge
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Allergic Conjunctivitis Treatment Cold compresses Topical antihistamines (over the counter) Topical mast cell stabilizers Combination topical antihistamines and mast
cell stabilizers
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Allergic Conjunctivitis Topical Therapy
Antihistamine (OTC,QID)
Vasocon-A Naphcon-A Opcon-A Visine-A
Mast cell stabilizer and antihistamine
• Azelastine (Optivar) • Emadastine (Emadine) (QID) • Epinastine (Elestat) (QID) • Ketotifen (Alaway) • Ketotifen (Zaditor --OTC) • Nedocromil (Alocril) • Olopatadine (Patanol) • Pemirolast (Alamast) • Olopatadine (Pataday,Pazeo) (QD) • Alcaftadine (Lastacaft) (QD)
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Viral Conjunctivitis
Adenovirus Highly contagious
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Viral Conjunctivitis Symptoms Burning discomfort Associated systemic symptoms: sore throat, fever,
malaise
Clinical findings Redness Watery discharge Palpable preauricular lymph node
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Viral Conjunctivitis Diagnosis
• AdenoPlus is immunoassay to detect adenoviral antigens
• Compared to cell culture 90% sensitivity, 96% specificity
• Cost $15-$25 per test • Reimbursable • Accurate diagnosis reduces treatment with
unnecessary and ineffective antibiotics
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Viral Conjunctivitis
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Viral Conjunctivitis
Treatment: symptomatic Cold compresses Iced artificial tears Acetaminophen Topical betadine
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Viral Conjunctivitis
Duration is 1-3 weeks Contagious period is for 1 week after onset
of symptoms Keratitis with specific viral serotypes may
cause decreased vision, light sensitivity Postconjunctivitis dry eye syndrome may
persist for several months
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Viral Conjunctivitis--Keratitis
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Bacterial Conjunctivitis
Caused by all common bacteria Symptoms: purulent discharge Clinical findings Conjunctival injection Purulent discharge
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Bacterial Conjunctivitis
Treatment: topical antibiotics QID for 7-10 days
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Ophthalmic Antibiotics Ointments
Erythromycin Bacitracin Sulfacetamide sodium Gentamicin Tobramycin Ciprofloxacin Polymixin B/Bacitracin Polymixin
B/Neomycin/Bacitracin
Solutions Sulfacetamide sodium Polytrim (Polymixin B, trimethoprim) Gentamicin Tobramycin Azithromycin Ofloxacin Ciprofloxacin Levofloxacin Gatifloxacin Moxifloxacin
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Hyperpurulent Bacterial Conjunctivitis
Copious discharge may indicate infection with Neisseria gonorrhoeae or meningitides;
requires urgent referral
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Dry Eyes
Symptoms Burning Foreign body
sensation Grittiness Tearing
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Dry Eyes Associated conditions Aging Sjogren’s syndrome Rheumatoid arthritis Stevens-Johnson syndrome Systemic medications: antihistamines,
diuretics, antidepressants
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Dry Eyes Treatment Lubricant eye drops (artificial tears) Lubricating ointment at bedtime Protective glasses and hat outdoors Omega three fatty acid supplements Restasis (topical cyclosporine) or Zidria
(liftegast) Punctal plugs or occlusion
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Punctal Plugs
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Vision Threatening Red Eye
Corneal infections Iritis/uveitis Acute angle-closure glaucoma
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Vision Threatening Red Eye Indications for Referral
Decreased vision Severe eye pain Light sensitivity Opacity on cornea
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Corneal Infections
Viral keratitis Herpes simplex most common
Bacterial keratitis Frequently related to soft contact lens
wear Fungal keratitis
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Herpes Simplex Keratitis Primary HSV Conjunctivitis with watery discharge Skin vesicles on lids Enlarged preauricular lymph nodes +/- corneal involvement with single or
multiple dendrites Recurrent HSV-may benefit by low dose
anti-viral prophylaxis
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Primary HSV Recurrent HSV
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Bacterial Keratitis
Most common in soft contact lens wearers Red painful eye Opacity on the cornea Requires ophthalmologic referral for culture
and sensitivity
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Bacterial Keratitis
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Iritis/Uveitis Inflammation in the anterior chamber (iritis) or
involving the entire eye (uveitis) Symptoms Pain Photophobia Decreased vision
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Iritis/Uveitis Clinical findings: Circumcorneal redness Pupil is smaller than normal Cell and flare in the anterior chamber
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Iritis/Uveitis Etiology Nongranulomatous:
Idiopathic Traumatic Ankylosing spondylitis Behcet’s disease Inflammatory bowel disease Herpes Lyme disease Postoperative Psoriatic arthritis Reiter’s syndrome Lupus Wegener’s granulomatosis JRA
Granulomatous: Sarcoidosis Tuberculosis Syphilis Toxoplasmosis Brucellosis
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Angle Closure Glaucoma
Obstruction of aqueous outflow due to occlusion of the trabecular meshwork by the iris. Occurs in patients anatomically predisposed with shallow anterior chambers.
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Angle Closure Glaucoma
Screening for susceptible patients: penlight held temporal and parallel to the iris reveals a shadow on the nasal iris in at risk patients.
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Angle Closure Glaucoma
Definitive therapy: Iridectomy
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Cataract
Clouding of the lens which may result in decreased vision
Leading cause of treatable blindness worldwide In US accounts for 50% of low vision cases in adults
> 40 Cataract surgery with IOL implantation one of most
common surgeries performed under Medicare
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Risk Factors Smoking Lifetime exposure to UV-B radiation Diabetes Inhaled, topical, and oral corticosteroid use Hypertension Myopia Obesity No significant delaying effect on cataract development with
vitamin supplementation
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Cataract
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Treatment of Cataracts
Cataract extraction with intraocular lens implant Indicated when patients are having difficulty with
their vision due to cataracts Typically small incision phacoemulsification
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Intraocular Lenses
Posterior chamber intraocular lens inserted into the lens capsule
Anterior chamber or sutured IOL used in certain cases
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Intraocular lenses
Multifocal IOL Accommodative IOL
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Preoperative Preparation Decide based on patient’s needs if cataracts
are visually significant Preoperative physical examination Laboratory studies and EKG as medically
necessary Preoperative topical antibiotics Anticoagulation—frequently may be
continued, but consult with ophthalmologist
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Tamsulosin Precautions Alpha blocker therapy may cause intraoperative
floppy iris syndrome and increase the risk of surgical complications
Discontinuation of alpha blockers for weeks to years does not reverse the effect
If a patient has a cataract and requires tamsulosin or other therapy, consider cataract surgery before initiating therapy
Tell ophthalmologist of any history of alpha blocker use (even if discontinued)
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Benefits of Cataract Surgery Better optically corrected vision Better uncorrected vision with reduced
spectacle dependence Increased ability to read or do near work Reduced glare Improved ability to function in dim light Improved depth perception and binocular
vision (reduced risk of motor vehicle accidents and falls with broken hips and shoulders)
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What Is New in Glaucoma? Glaucoma is a disease of the optic nerve with a
characteristic pattern of atrophy and visual field loss Intraocular pressure is the only treatable risk factor Lowering intraocular pressure has been shown to
reduce or arrest visual field loss in all types of glaucoma
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Glaucoma Management Medications: Prostaglandin analogs-latanoprost, bimatoprost,travoprost Beta-blockers-timolol Alpha-blockers-brimonidine Topical carbonic anhydrase inhibitors-dorzolmide,
brinzolamide Cholinergics-pilocarpine
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Glaucoma Management
New medications Vyzulta-lantanoprostene bunod. Combination prodrug of
latanoprost and butanediol mononitrate. Latanoprost lowers IOP by increasing aqueous humor outflow through uveoscleral pathway, butanediol through trabecular meshwork
Rhopressa-netarsudil. Is a Rho-associated protein kinase inhibitor lowers IOP by increasing aqueous humor outflow through trabecular meshwork
Rocklatan-comgination of latanoprost and netarsudil
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Glaucoma Management New surgical options: MIGS I-stent: inserted through TM into Schlemm’s canal at time of
cataract surgery. IOP reduction 7.0 mmHG at 24 months, 5.9 at 36 months
Hydrus: inserted into Schlemm’s canal at time of cataract surgery. IOP reduction 7.6 + 4.1 mm Hg
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Glaucoma Management New surgical options Endoscopic cyclophotocoagulation Goniotomy: Remove trabecular meshwork,
Kahook dual blade, trabectome,GATT Canaplasty: dilate Schlemm’s canal +/- stent with
suture Reduce medication burden Address disease earlier in course May affect long-term outcome of disease
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Dry Age-Related Macular Degeneration Drusen Retinal thinning Slow No proven treatment Studies with stem cells Reduce risk: No smoking Control weight Green leafy vegetable Antioxidants AREDS2 formula
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Wet Age-Related Macular Degeneration Neovascularization Bleeding Leakage of fluid Scar tissue formation Severe, rapid Treatment: Anti-VEGF
intravitreal injections with bevacizumab (Avastin),aflibercept (Eyelea),Ranibizumab (Lucentis)
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Amsler Grid
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Red Flag Signs and Symptoms Require urgent referral Decreased vision Metamorphopsia (distorted vision) Severe eye pain Red eye with light sensitivity Corneal opacity Flashes and floaters Binocular double vision
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Flashes and Floaters
Patients need to be examined to detect and treat retinal holes and detachments.
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What is the differential diagnosis?
Posterior vitreous detachment Retinal hole/detachment Vitreous hemorrhage Posterior segment inflammation Trauma Migraine
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New Onset Diplopia
Is this a neurologic emergency? Diplopia that is not improved by covering
one eye requires a neuro-ophthalmic or neurologic evaluation
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Diplopia Monocular:
abnormalities in the refractive media Corneal (high
astigmatism) Lenticular—cataract or
dislocated lens Retinal (rarely)
Binocular: misalignment of the visual axis Cranial nerve palsy Giant cell arteritis Demyelinating disease Myasthenia gravis Thyroid orbitopathy Orbital myositis Other causes
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Key Points Urgent referral: severe pain, light sensitivity,
opacity on cornea, binocular diplopia, sudden decreased vision, metamorphopsia
Prompt referral: Flashes/floaters, gradual decreased vision
Next best steps No topical antibiotics for viral conjunctivitis Blepharitis is underdiagnosed, undertreated, and
common