PRIME: A Novel Educational Model for Preparing the 21st Century WorkforcePilot Project InvolvingUniversity of California San DiegoComputer Network Information Center, ChinaMonash University, AustraliaNational Center for High-performance Computing, TaiwanOsaka University, JapanGabriele Wienhausen, UCSDPeter Arzberger, UCSDDavid Abramson, Monash University

The Stakes are HighWhat nations dont know can hurt them. The stakes involved in study abroad are that simple, that straightforward, and that important. college graduates today must be internationally competent. [Lincoln Report 2005]

Why Should We Care?Most of the major problems facing our country in the 21st Century require every young person to learn more about the worlds regions, cultures, and languages. [Colin Powell] Our society is heterogeneous, multiculturalLess than 1% of US undergraduates in US study abroad [IIE AnnRep05]Diverse teams are more creative and find better solutions than homogeneous teams. Nokia CEO Jorma Ollila. Students must be prepared to compete globally for jobs and opportunities

Vision for Undergraduate Educationencourage every student to complete an international experience that would include either study, research, or work abroad. [Bartlett04 Harvard University Review Committee]

Pacific Rim Experiences for Undergraduate (PRIME) Providing students international interdisciplinary Research Apprenticeships and Cultural Competency Learning ExperiencesBegun in 2004 as

a proof of concept for honing undergraduate research and cultural competency skills

an intensive international experiential learning experience

About UCSD: The InstitutionInnovation and interdisciplinarity the traditionBudget: $2.2 billion (24% federal, 12% State)Students: Fall 2007: 45,000 applications (second highest in UCsystem); Admitted freshman GPA 4.06; SAT-I 634 Critical Reading, 670 Math, 640 WritingFALL 2006: 26,876 Enrolled1st nationally: students abroad in full-year programs4th nationally research institutions- international scholars hostedSpecialize Resources: SDSC, IRPS, SOE, SIOCalit2: Living in the future, Multidisciplinary Approach to Societal IssuesRankings:Hottest institution in the nation for students to study science (Newsweek and the 2006 Kaplan/Newsweek College Guide)

About UCSD: RankingsHottest institution in the nation for students to study science (Newsweek and the 2006 Kaplan/Newsweek College Guide)7th in the nation in National Academy of Sciences membership7th best public university in the nation, and 32nd among the nations top 50 universities.(U.S. News and World Report)8th nationally for best values in public colleges in the U.S (Kiplinger's Personal Finance)13th internationally (2005 Academic Rankings of World Universities conducted by Shanghai Jiao Tong University in China)

About UCSD: Research Impact5th in the nation in federal R&D expenditures (NSF 2005)7th highest-impact research institution in the nation from 2001-2005, based on the citation impact of published research in science and the social sciences (Thomson Scientific)Jacobs School of Engineering ranked 3rd (U.S. News, 2007 survey)Bioengineering program ranked 3rd

UCSD: Hub of Community Cyberinfrastructure DevelopmentBiomedical Informatics Research Network (NIH).PI: Mark EllismanOptIPuter (NSF). PI: Larry SmarrGEOsciences Network (NSF). PI: Chaitan BaruCAMERA Metagenomics (Moore Foundation). PI: Larry SmarrNational Biomedical Computation Resource (NIH). PI: Peter ArzbergerPRAGMA (NSF). Grassroots international CI collaboration. PI: Peter Arzberger NOTE: All above have Phil Papadopoulos as co-PI; leading Rocks developmentOthers: Network for Earthquake Engineering Simulation (NSF). PI: Ahmed Elgamal; Ocean Observatories Initiative (OOI, NSF). PI: John Orcutt; More

Calit2: Multidisciplinary LabWorking in the FutureFuture is nowWork on technologies that will be commonplace in 5 to 10 yearsMultidisciplinary by designNew mechanism to address large-scale societal issues by bringing together multidisciplinary teams of the best mindsHome/co-home of many CI projects:OptIPuter, CAMERA; OOI, NBCR, PRAGMAInteract with industry (by design)Bi-directional transfer of ideas and people

PRIME: Merging Campus Units and Programs to Create a Novel ModelSixth Collegehistorical and philosophical connections among culture, art and technology; experiential learning Academic Internship ProgramCourse credit and career counselingInternational Center Cultural awareness, international experiencePacific Rim Application and Grid Middleware Assembly (PRAGMA)Network of people and projects focused on use or development of cyberinfrastructure

http://www.pragma-grid.netOverarching GoalsPRAGMAA Practical Collaborative Framework. Strengthen Existing and Establish New Collaborations Work with Science Teams to Advance Grid Technologies and Improve the Underlying Infrastructure

In the Pacific Rim and Globally

PRAGMA Member InstitutionsKUNECTECTNGCThailandUoHydIndiaMIMOSUSMMalaysiaASGCCNCHCTaiwanAISTCCSCMCNARCOsakaUTITechJapanBIIIHPCNGOSingaporeMUAustraliaAPACAustraliaJLUChinaCalIT2CRBSSDSCUCSDUSACICESEMexicoNCSAStarLightTransPAC2USACNICChinaCRAYPNWGUSAKBSIKISTIKonkukKoreaAPANJapan

PRAGMA Overview and ApproachProcess to Promote Routine Use Team ScienceApplication-Driven CollaborationsApplicationsMiddlewareOutcomes

Improved middlewareBroader UseNew CollaborationsTransfer Tech.StandardsPublicationsNew KnowledgeData AccessEducation

PRAGMA Highlights of 2006 - 2007Simulating the Australian Monsoon and the Effect of WildfiresPRAGMA Biosciences PortalPRAGMA Leads Application Experiment of Grid Interoperation in GIN TestbedPRAGMA Establishes Certificate Authority (CA) Using Naregi-CA SoftwareExpanding the Collaboration GridBuilding Communities, Catalyzing CollaborationsPRIME and PRIUSMore accomplishments in the Working Group sections

PRIME: Leveraging Campus StrengthsStudent Quality, Units Strengths, Projects LeadershipA Microcosm of Diversity23% of the undergraduate students immigrants 43% of the students speaking a language in addition to English (of those more than 50% a language from the Asia Pacific rim)Faculty and Researchers More than 15 researchers and facultyhttp://prime.ucsd.edu/researchers.htmLocation

Actively Involved 2007Kim Baldridge, Comp. Chemistry, GridMark Ellisman, CI, BIRN, NCMIRJason Haga, BioengineeringMasa Hoshijima, CRBS, HeartRoy Kerckhoffs, BioengineeringWilfred Li, NBCR, CI, Avian FluAndrew McCulloch, Cardiac ModelingAnushka Michailova, Cell ModelingTomas Molina, NCMIRJurgen Schulze, Visualization

PRIME ModelResearchUCSD then HOST ResearchersPrior Year StudentsCulturePrior Year Students and StaffUndergraduateStudentsProjectDefinition &Dual MentorsProjectPreparationProjectConductProjectReview &Presentatione.g., SCXYPre-DepartureWeeklyQuestionsPost-ReturnResearchExperienceCultural AwarenessConfidenceTransformationGlobally AwareWorkforcePROGRAMOUTPUTSCollaborationsPublicationsSoftwareHost Site- ResearchersPRIUSPublicationCareerAdviceHuman and Professional Network of PRAGMA

Currently there are 4 host sites: Osaka, NCHC, Monash, CNIC;Plan to add 5 more sites: USM, NTU, U Auckland, U Waikato, U Hyderabad; And 2 new US mentoring sites: NCSA, U WI Monash UAustraliaSource Cindy ZhengPRIME Host SitesOsaka UJapanUCSDUSAUZurichSwitzerlandCNICChinaNCHCTaiwanAU Photo: Iwen Wu

PRAGMA Host Institutions and MentorsOsaka UniversityShinji Shimojo, Susumu DateBiogrid, Telescience, Tile Display WallsPRIUS*Monash UniversityDavid AbramsonComputer Science (Nimrod), Comptl Chem, Cardiac Modeling, Joint Paper*National Center for High-performance ComputingWhey-Fone Tsai, Fang-Pang LinEcogrid, Tile Display Walls, GEOGridGLEON, CREON*Major Individual AwardComputer Network Information CenterBaoping Yan, Kai Nan, Zhonghua LuBioinformatics, Networking, Tile Display Walls, GeosciencesAvian Flu Grid* NCREE: Earthquake Engineering

PRIME 2005 Presentations at iGRID 2005Phylogeny Determined by Incomplete Protein Domain Content, I.Lee, CNICA visualization of network measurements, J.Lee, CNICDeployment and Extension of JuxtaView for the Scalable Adaptive Graphics Environment, C.Cheung, NCHCDeveloping the Interface between PDA and Sensors, O Langman, NCHC* (from U Wisconsin)Visualizing internet connectivity using Cytoscape, S.Lee, NCHCExtending EcoGrid Capability, D.Leu, NCHC*BOINC as a Nimrod Resource for Quantum Chemistry, J.Hwang, MonashComputational Grid Tools for Protein-Ligand Docking Studies, L Berstis, MonashModeling Cardiac Rhythm Alternation, J.Nevo, MonashSNPs, Protein Structure and Disease, D.Bitton, MonashComputational Cardiac Modeling, D.Dederko, MonashThe Development of A Querying System for Structured Metadata in a Datagrid Environment, J.Chen, OsakaVisualization Tools for Bio-molecular Simulation, C.Liang, OsakaA Bio-molecular Simulation Portal, E.Wang, Osaka

prime.ucsd.edu/presentations

PRIME 2007Projects (some)Avian Flu (CNIC)Molecular Screening (Osaka)Quantum Chemistry (Monash)Tile display walls (CNIC, NCHC, Osaka)Cardiac Modeling (Monash)Imaging Pipeline (Osaka)Computational materials modeling (NCHC)Mixture of new projects and continuing onesTotal number of students 15Source:L. ChengSource: A. Altshuler, I WuSource: C.Chang, D Goodman, M Levesque

Cultural Competency and Its Stages [LaBrack]Start by Observing Differences Not judging them Unconscious incompetence the state of blissful ignorance unaware of cultural differences or that you may be making cultural mistakes or misinterpreting much of the behavior going on around you. You have no reason not to trust your instincts;Conscious incompetence You now realize that differences exist between the way you and the local people behave, though you understand very little about what these differences are, how numerous they might be, or how deep they might go.); Conscious competence You know cultural differences exist, you know what some of these differences are, and you try to adjust your own behavior accordingly. It doesnt come naturally yet) Unconscious competence You no longer have to think about what youre doing in order to do the right thing. Culturally appropriate behavior is now second nature to you; you can trust your instincts because they have been reconditioned by the new culture..

Questions During ExperiencePre-Departure - Anticipation: What do you look forward to; what do you worry about, what will you miss most/least, what is the biggest single challenge?During Stay: Logistics; Critical Incidences; Communication Styles; Most valuable lesson and how that impacts your view of host and home culture; What you has wished youd known; Wow will you preserve your memories; Wow will you integrate your new perspectives into your life?

Critical Incidents Lead to AwarenessAn occurrence that in some way raises questions and leads the participants to wonder What just happened? and Why? EXAMPLES (2006):American TV Programming: Isnt everyone rich, and all females act like Carrie Bradshaw (star of Sex in the City) (China, Taiwan)National Image over Individual Rights: Flight attendants on Air ChinaIndividual or the Group: Value of groups to support others versus the lone cowboy (China and Taiwan)Work Ethic: Very strong compared to US, emphasizes productivity and team work as the path to professional successWillingness to Help: Surprise in Taiwan in helping when car was stuck; In Australia when individuals seemed lostFood: Japanese love food (quality, not quantity)Hierarchy: In Japan, there is a hierarchy based on social statusDress: In Japan and Australia, more formal and if not observed, people will respond differently. World View: Australians look more at the global picture of important issues better than Americans Conservation: Toilets in AustraliaWhats Up With Culture: On-Line Cultural Training Resource for Study Abroad (www.pacific.edu/culture) (LaBrack)

Value to Host InstitutionExpose and train their staff to work in an international context Build local workforce Build collaborations via student and projects Conduct research Internationalize host institution

Question was motivated by discussion from NSF program officer

Evolving Face of PRIMELaunched 2004# students9,13,14,15# women0,5,8, 8Added CNICin 2005Engineersand now science, artGeographic SpreadMonash: 17Osaka: 14NCHC,NCREE: 11CNIC: 9

Lessons Learned - Improvements to the ProgramLanguage is important. The Spring Quarter is a crucial preparation period. Identifying a mentor and creating a project are application barriers. Aggressive recruiting is required to assure gender parity. Previous students are effective recruiters (and mentors). [Wu06].

PRIME, PRIUS and PRAGMASC05 and SC06

Publications and SoftwareAmaro R, Minh DDL, Cheng L, Olson A, Lin JH, Li W, McCammon J, Remarkable Loop Flexibility in Avian Influenza N1 and its Implications for Antiviral Drug Design, Journal of the American Chemical Society, ASAP Web Release Date: 01-Jun-2007; (Communication) DOI: 10.1021/ja0723535Abramson D, Amoreira C, Baldridge K, Berstis L, Kondrick C, Peachey T. "A Flexible Framework for Protein-Ligand Docking", submitted for publication2nd IEEE International Conference on e-Science and Grid Computing. Dec. 4- 6, 2006, Amsterdam, Netherlands. Sudholt W, Baldridge K, Abramson D, Enticott C, Garic S, Kondrick C, Nguyen D. Application of Grid Computing to Parameter Sweeps and Optimizations in Molecular Modeling. Future Generation Computer Systems (Invited), 2005. 21, 27-35.Two more in progressCytoscape Plug In: Hyperbolic Layout PluginRobert Ikedahttp://www.cytoscape.org/plugins2.php

In Their Own WordsI can say without question that my involvement with PRIME, more so than any course I took, helped give me the level of professional understanding and maturity that I believe will be necessary for success in graduate school, a professional career, and beyond. The leadership skills and firsthand technical experience gained through working in international collaborative environments are invaluable assets to our generation of engineers and scientists, who must learn to function on the ever-growing stage of global research. John Colby, PRIME 2004 (UCLA Med School)I hope this year's PRIME group is shaping up well for the summer- I don't think any of the candidates can really know until they graduate just how valuable the program is. It definitely had a huge impact on me (it's fun to talk to your coworkers about spending 10 weeks working in another country during college!). Chris Kondrick, PRIME 2004 (Heavy Iron Industry)

In Their Own WordsI recently received and accepted a summer internship at Abbott Vascular as an R&D engineer. I was told that historically, 80% of the interns are offered full-time positions at the conclusion of the internship. . My participation in PRIME began a cascade of events and taught me lessons that guided me through various research and internship experiences [The program] taught me the importance of networking and creating something out of that network.Ian Lee PRIME 2005

In Their Own WordsLanguage: I would like to be a part of that (i.e., Chinas growing economy) in the future. However, it will be impossible if I cant read or write the language. Lisa Zhao 2006Experiential Learning: Knowing about a culture and experiencing a culture are completely different things. Robert Sy 2006 I heard a lot about living in Japan from Japanese friends at UCSD. It was not until I lived there that I began to understand what they were talking about. Marshall Levesque 2006Transformational:I understand now that I need to be able to accept failure, and build myself up again and begin the work with the same passion and energy that I originally had. I should not associate failure with disappointment, but think of it as a learning experience that causes me to seek other ways of approaching certain difficulties. Mahboubeh Hashemi 2006 (Abbott Labs)

YouTube Google Pacific Rim Experiences youtubewww.youtube.com/?v=4lY6x0S3IoA

Tracking - Partial36 in first three years; 15 in year 4 (2007)Graduate School (9): Stanford (CS), USC (BioEng), UCSC (CS), Columbia (BioEng), UCSD (ECE, BioEng, CSE), U Zurich (Chem), UCLA (Med)Industry (6): Amazon.com, Abbott Vascular (2), Heavy Iron Studios, Intuit, KPFF, More work to do in the future

PRIME Model ExtendedOsaka University

From Pilot to Sustainable ProgramThe overarching goal of our next stepsApply what we have learned from the pilot program in order toDevelop an integrated and sustainable undergraduate international research program that Serves as a model for undergraduate education in the 21st Century at a world-class research university, Prepares students to become effective global professionals and citizens, and Gives students a head-start on careers in science and technology research

Key Future ActivitiesBuild a Sustainable Program - that can scaleEnhance the Program (research, location, culture)Transfer, Assess, and Disseminate our model, lessons learned and experience

Building a Sustainable ProgramDevelop example in specific program: Bioengineering40% of the students in first 3 years were BioEngEngage activities in Calit2Interaction with industry, innovative disseminationProvide model for UCOPCreate Steering Committee to work program into mainstream UCSD activities

Enhance the ProgramImprove the quality of the research experience by starting it earlier and extending it longitudinally through continued researchBuild cultural awareness curricula modulesExtend the program to new sites

Currently there are 4 host sites: Osaka, NCHC, Monash, CNIC;Plan to add 5 more sites: USM, NTU, U Auckland, U Waikato, U Hyderabad; And 2 new US mentoring sites: NCSA, U WI UZurichSwitzerlandUoHydIndiaUSMMalaysiaNCHCTaiwanNTUSingaporeMonash UAustraliaNCSAUSAU AucklandU WaikatoNew ZealandCNICChinaSource Cindy ZhengU WIUSAOsaka UJapanPRIME Host SitesUCSDUSA

Current and Future Sites

Host InstitutionKey Research Areas1ST YrCMC, Osaka University, JapanDr. S. Shimojo, Dir.; Dr. S. Date, ResearcherTelescience, Bioinformatics, IPv6, HDTV, Data Grid, Tile Display2004Monash University, MelbourneAustralia Dr. D. Abramson, Prof., Computer Sci.Grid Computing, Geosciences, Comptl Chemistry, Bioengineering, Bioinformatics2004 NCHC, Hsinchu, TaiwanDr. FP LinGrid Application LeadGrid Computing; EcoGrid; Visualization; Telescience; Tile Display Technology2004NCREE, (with.NCHC), Taipei, TaiwanDr. KC Tsai,DirectorEarthquake Engineering and its Cyberinfrastructure 2004 CNIC, CAS, Beijing, ChinaDr. K.Nan, Scientific Databases; Dr. LuData Grids, Bioinformatics, Astronomy, Geosciences, Tile Display Technology2005U of Waikato, Hamilton, NZProfs. D. Hamilton, Eco., T. McGregor, CSecology; networking, wireless technology; modeling; GLEON 2008Nanyang Tech. U, SG Prof. F. Lee, Asc ChairGrid Computing and Accounting Systems2008U. of Auckland , NZProf. P. HunterBioengineering2008U. of Hyderabad, IndiaDr. A. AgarwalGeosciences2008U. Sains Malaysia, Dr. H. WahabComptl Chemistry, Grid Computing2008

Transfer, Assess, and DisseminateTransfer program to other sitesU Wisconsin and NCSAAssess Students and ProgramWork with Bruce LaBrackDisseminate the research, lessons learned, and cultural awareness curriculumMultimedia

Interaction with Industry:Strategic Advice and FeedbackAdvisory Committee: Understanding industries need directly can improve the programs goal to educate students so that they become culturally aware and develop the skills to work in multi-cultural, multidisciplinary teams.Charge for an Advisory Board:Assess efficacy and quality of program, in terms of knowledge and experience gained by studentProvide advice to improve students preparation for a career (in industry, government, academics) Help to connect the PRIME program to other interested industry partners

Benefits and Expectations in Partnership with IndustryBenefitsInteract with talented, highly motivated beginning researchers and possibly influence their career decisionsHelp shape program to benefit US WorkforceIdentify possible future employeesLearn more about Calit2 and UCSDMake connections with other parts of their corporation in host site countries and build ties between PRIME/PRAGMA mentors in those countries.ExpectationsAttend Annual Meetings at UCSDInteract with students, who will give presentation of their projectsAdvocate for the program and its goals in their own companies and in their industryAssess the quality of the program

Why we must succeed? and How?Lincoln Report makes clear the essential need for our studentsWe need partners to succeed.

Is Industry Willing to be a Partner?Dialog: Are we creating a workforce for industry? For your industry?Advice: What would be a value to industry? To your industry?Interaction: How can we get advice?Support: What would this entail?

PRIME: Key IngredientsResearch Apprenticeship Immersion in real researchDual MentorsCreating ProjectAnd doing this as part of the application processPresenting ResultsExperiential Learning of CultureInternational SettingsPre, during, and post experience mentoring and curriculumMultiple campus components that are complementaryE.g. Sixth College, AIP, International Center, Bioengineering departmentStudents from previous years engaged as mentors, recruitersHost sites willing to commitment to long-term involvementProfessional PreparationResearch Experience captured on transcriptProfessional seminar in resume preparation and highlighting the experienceHuman support AND research network in place: PRAGMA

AcknowledgmentsLinda Feldman, AIPBill Clabby, Program Abroad UCSD, soon ISA: International Studies Abroad as Regional Director of University RelationsTeri Simas, Program CoordinatorMentors atUCSD and Host SitesNSF OISE 0407508Calit2: Ramesh Rao, Larry SmarrPRAGMA: Phil Papadopoulos, Mason Katz, Cindy Zheng, Wilfred LiPRIME Students

A Final ThoughtPeace and prosperity around the world depend on increasing the capacity of people to think and work on a global and intercultural basis. As technology opens borders, educational and professional exchange opens minds.[i] [i] Annual Report IIE 2005, and http://www.iie.org/ About

PRIME 2007 and BeyondQuestions?With President Miyahara Osaka UNCHCs New Facility TaichungMonash U in MelbourneMelissa DiCiero-MonashLao She Tea HouseThankYou

*[Lincoln05] Global Competence and National Needs: Commission on the Abraham Lincoln Study Abroad Fellowship Report Program (2005) http://www.lincolncommission.org/report.html , page ii, page xiii

**Diverse teams are more creative and find better solutions than homogeneous teams. Nokia CEO Jorma Ollila. http://www.nokia.com/link?cid=EDITORIAL_4055 (25 July 2006)

[Bartlett04] Bartlett T, Whats Wrong With Harvard Chronicle of Higher Education May 7 2004. Volume 50, Issue 35, Page A14.

http://www.fas.harvard.edu/curriculum-review/ for May 2007 update*Started in 2004*http://ucsdnews.ucsd.edu/about/ Innovation is our tradition: Nestled along the Pacific Ocean on 1,200 acres of coastal woodland, UCSD is a powerful magnet for those seeking a fresh, next-generation approach to education and research. Since its founding over four decades ago, UCSD -- one of the ten campuses in the world-renowned University of California system -- has rapidly achieved the status as one of the top institutions in the nation for higher education and research. UCSDs interdisciplinary ethos and tradition of innovation and risk-taking underlie its research strength and ability to recruit top scholars and students.Budget: UCSDs annual revenues are $2.2 billion. (24% of this total is from the federal government for research; 12% is from the State of California for education.)Students: UCSD received over 45,000 applications for fall 2007 admission (the second highest application rate in the University of California system and possibly in the nation). The average high school GPA of admitted freshmen for fall 2007 was 4.06 and average SAT-I Reasoning scores were 634 Critical Reading, 670 Math and 640 Writing. Total campus enrollment for fall 06 was 26,876. UCSD ranks 1st nationally among major research universities sending students abroad in full-year programs, and 4th among U.S. research institutions in the number of international scholars hosted.Economic Impact: UCSD is an engine for regional economic growth. UCSD faculty and alums have spun-off close to 250 local companies, including over a third of the regions biotech companies. In addition, UCSD is San Diego Countys third largest employer, with a monthly payroll in excess of $90 million, and over 26,000 employees.Specialized Resources: UCSDs graduate and professional schools include Scripps Institution of Oceanography; School of Medicine; School of International Relations and Pacific Studies; Center for U.S. Mexican Studies; Skaggs School of Pharmacy and Pharmaceutical Sciences; Jacobs School of Engineering (graduate and undergraduate), and Rady School of Management. The campus is also home to the San Diego Supercomputer Center; California Institute for Telecommunications and Information Technology (Calit2); Center for Research in Computing and the Arts; Center of Interdisciplinary Science for Art, Architecture, and Archaelogy (CISA3); Institute on Global Conflict and Cooperation; and Institute of the Americas.

*UCSD was named the hottest institution in the nation for students to study science by Newsweek and the 2006 Kaplan/Newsweek College Guide.UCSD ranks 7th in the nation in National Academy of Sciences membership. (The top universities, in rank order, are: Harvard, Stanford, UC Berkeley, MIT, Princeton , Caltech, UCSD, Yale, Univ. of Wisconsin-Madison , Univ. of Chicago and Univ. of Washington.)U.S. News and World Report ranks UCSD as 7th best public university in the nation, and 32nd among the nations top 50 universities.UCSD was ranked the 6th best university in the nation by the Washington Monthlys 2005 College Guide, based on the positive impact the university has had on the country.The journal Foreign Policy ranked UCSD 9th in the nation for international relations studies and 10th for international public policy studies.The National Research Council ranks UCSD 10th in the nation in the quality of its faculty and graduate programs. (The top ten, in rank order, are: UC Berkeley, MIT, Harvard, Princeton, Stanford, CalTech, Yale, Chicago, Cornell, UCSD). The NRC ranks oceanography and neurosciences 1st in the nation. Kiplinger's Personal Finance ranks UCSD 8th nationally for best values in public colleges in the U.S. UCSD outranks UC Berkeley and UCLA in this ranking of the top 50 values in public colleges. The Princeton Review 2007 edition of Americas Best Value Colleges also lists UCSD among 150 best values. The 2005 Academic Rankings of World Universities conducted by Shanghai Jiao Tong University in China ranked UCSD 13th internationally.

*UCSDs total research funding for 2004-05 was $728 million. The National Science Foundation ranks UCSD 5th in the nation in federal R&D expenditures. (The top ten research universities, in rank order, are: Johns Hopkins, Washington, Stanford, Michigan, UCSD, UCLA, Pennsylvania, Wisconsin-Madison, MIT, UCSF.)The Milken Institute ranks UCSD 6th among the worlds leading universities in the strength of its biotechnology research publications and 8th in the number of biotech patents issued.Thomson Scientific ranks UCSD the 7th highest-impact research institution in the nation from 2001-2005, based on the citation impact of published research in science and the social sciences. Based on the number of citations, UCSD ranks 2nd in the nation in the field of pharmacology, 4th in the nation for molecular biology and genetics, and 5th in the nation for clinical medicine.In the 2007 survey of graduate programs by U.S. News, the Jacobs School of Engineering ranked 3rd and the School of Medicine ranked 1st in the nation for research expenditures per faculty member. Total federal, state and industry research support at the School of Medicine is $273.7 million, and at the Jacobs School, $129 million.

**New Since Dec 2006

29 Members from around the Pacific Rim.STEERING COMMITTEE MEMBERS designated by *academia sinica computing centre (ascc)Simon Lin, sclin@gate.sinica.edu.tw; Eric Yen, eric@sinica.edu.twasia-pacific advanced network (apan)Seishi Ninomiya, snino@affrc.go.jp; Kento Aida, aida@ip.titech.ac.jpaustralian partnership for advanced computing (apac)John OCallaghan,* john.ocallaghan@apac.edu.au; DavidAbramson,* davida@csse.monash.edu.au; Bernard Pailthorpe,*bap@acmc.uq.edu.aubioinformatics institute, singapore (bii)Santosh Mishra*, santosh_mishra@bii.a-star.edu.sgcenter for computational sciences (ccs), university oftsukubaMitsuhisa Sato, msato@cs.tsukuba.ac.jp; Taisuke Boku,taisuke@cs.tsukuba.ac.jpcollege of computer science and technology (ccst), jilinuniversity (jlu)Xiaohui Wei, weixh@jlu.edu.cncomputer network information center (cnic), chineseacademy of sciences (cas)Baoping Yan,* ybp@cnic.ac.cn; Kai Nan,* nankai@cnic.ac.cncray inc.Geert Wenes, geertw@cray.com; Kazunori Mikami, mikami@cray.comcybermedia center (cmc) and research center for ultrahighvoltage electron microscopy, osaka universityShinji Shimojo,* shimojo@cmc.osaka-u.ac.jp; Susumu Date,*date@ais.cmc.osaka-u.ac.jpglobal scientific information and computing center(gsic), tokyo institute of technology (titech)Satoshi Matsuoka,* matsu@is.titech.ac.jp; Hidemoto Nakada, hidenakada@aist.go.jpgrid technology research center (gtrc), national instituteof advanced industrial science and technology (aist)Satoshi Sekiguchi,* sekiguchi@m.aist.go.jp; Yoshio Tanaka,*yoshio.tanaka@aist.go.jpkasetsart university (ku)Surasak Sanguanpong, Surasak.S@ku.ac.th; Putchong Uthayopas,pu@ku.ac.thkorea basic science institute (kbsi)Inho Gim, inhogim@kbsi.re.kr; Jung-Eok Gu, jekoo@kbsi.re.krkorea institute of science and technology information(kisti)Jysoo Lee,* jysoo@kisti.re.kr, Kum Won Cho,* ckw@kisti.re.krnational agriculture research center (narc)Seishi Ninomiya, snino@affrc.go.jp; Masayuki Hirafuji,hirafuji@affrc.go.jpnational center for high-performance computing(nchc), national applied research laboratoriesWhey-Fone Tsai,* c00wft00@nchc.org.tw; Fang-Pang Lin,*fplin@nchc.org.twnational center for supercomputing applications (ncsa),university of illinois at urbana-champaign (uiuc)Radha Nandkumar, radha@ncsa.uiuc.edu; Danny Powell,danny@ncsa.uiuc.edunational electronics and computer technology center(nectec)Piyawut Srichaikul,* piyawut.srichaikul@nectec.or.th, ChalermpolCharnsripinyo,* chalermpol.charnsripinyo@nectec.or.th, SornthepVannarat, sornthep.vannarat@nectec.or.thnational grid office (ngo), singaporeLawrence Wong, lwong@i2r.a-star.edu.sg; Hing Yan Lee,hingyan@ngp.org.sgpacific northwest gigapop (pnwgp)Jacqueline Brown, jbrown@cac.washington.edustar tap/starlight initiativeMaxine Brown,* maxine@uic.edu; Tom DeFanti, tom@uic.eduThai National Grid CenterPutchong Uthayopas, Putchong_ut@thaigrid.or.thtranspac, indiana universityJames Williams,* william@indiana.edu; Donald McMullen,*mcmullen@indiana.edu; John Hicks, jhicks@iupui.eduuniversiti sains malaysia (usm)Ahmad Yusoff Hassan,* cio@usm.my; Habibah A. Wahab,*habibahw@usm.myuniversity of california, san diego (ucsd), including Calit2,San Diego Supercomputer Center (SDSC), Center for Research inBiological Systems (CRBS), National Center for Microscopy andImaging Research (NCMIR), and National Laboratory for AppliedNetwork Research (NLANR); Peter Arzberger,* parzberg@ucsd.edu;Philip Papadopoulos,* phil@sdsc.edu; Mason Katz, mjk@sdsc.edu;Teri Simas, simast@sdsc.eduuniversity of hyderabad (uoh)Arun Agarwal,* aruncs@uohyd.ernet.

New MembersInstitute of High Performance Computing (iHPC) Terrance Hung Centro de Investigacion Cientifica y de Educacion Superior de Ensenada (CICESE) Raul Hazas Izquierdo Malaysian Institute of Microelectronic Systems (MIMOS) Mashkuri Yaacob

CIRCLED SITES had demonstrations at IGRID 18 of 49 Demos were PRAGMA members

Partnership: relationship (between individuals or groups) characterized by mutual cooperation and responsibilityCollaboration: work together, especially in a joint intellectual effort

**Develop and deepen collaborations in the specific application areas To focus our grid developments and to produce scientific insight., Enhance and expand our routine use application grid laboratory To allow for middleware and applications codes to be tested, improved, and lessons learned to be advanced to othersCreate multi-way software dissemination pathways, To ensure access and use of software and middleware through the grid community and to promote standards Strengthen and expand the Pacific Rim community of grid users and developers To broaden its impact on and interactions with new groups and efforts in and beyond the Pacific Rim

*Source of Diversity[UCUES].

https://tritonlink.ucsd.edu/portal/site/prospective-students/menuitem.24134797e5e2fd95a0b86710514b01ca?storyID=20688

*****Here is an image with Tamiflu bound to Neuraminidase from H5N1 as viewed through ADT's View Docking in Context feature. Broken green dots shows hydrogen bonds. Spheres shows atoms that interact with the ligand. Dark colored molecular surface of the ligand represent those with interactions to the receptor. Red is oxygen atom, Blue is nitrogen, and blue is added hydrogen atoms.

more stable ionic models in rabbit (LabHEART)and human ventricular myocytes. This work continues thework of previous PRIME students in each of the precedingtwo years. The students worked on determining Nimrod/Gparameter values to improve the model stability over longtime periods and at different frequencies of stimulation.

: closer look of 1WBT and ligandA step in the screening pipeline

These can be found at:http://video-jsoe.ucsd.edu/calit2/PrimeNSF.wmv *or see http://www.youtube.com/watch?v=4lY6x0S3IoA)*To download the .wmv file, go to http://video-jsoe.ucsd.edu/calit2/and right-click on the PrimeNSF.wmv file then Save Target As... to any directory on the PC. After that click on the file, and it should launch the Windows Media player automatically.Australians well mannered you bump into them and they sorryAustralians open to (some) strangers

an occurrence that in some way raises questions and leads the participants to wonder What just happened? and Why? Everyone who goes abroad is, eventually and inevitably, faced with some kind of a situation we could call a critical incident, even if s/he is unaware of it at the time or cant immediately figure out what was going on. Such encounters illustrate the tricky nature of interpreting everyday events in a different culture.*Language is important. This is particularly true in Japan where first-year students - if they lacked basic language knowledge - felt more isolated outside their laboratory setting. We therefore strongly encourage students to acquire a foundation of basic language skills prior to their departure. This will increase abilities to explore the host country and to gain insights into culture. We advise students on UCSDs numerous opportunities, to obtain fundamental language skills. As Lisa Zhao, PRIME 2006 CNIC, noted: I would like to be a part of that (i.e., Chinas growing economy) in the future. However, it will be impossible if I cant read or write the language. The Spring Quarter is a crucial preparation period. Based on feedback from both first- and second-year students, PRIME acceptance decisions have to be made by the end of the Winter Quarter. This assures that the Spring Quarter can be used to detail the summer research projects and to participate in the cultural competency curriculum.Identifying a mentor and creating a project are application barriers. Many students found identifying a mentor and identifying a research question and projects so daunting that they gave up before trying. We responded by instituting a pre-application process, in which the PIs advise the students on how to identify a suitable UCSD mentor and how to initiate a dialogue with a potential faculty mentor. In addition, we have published summaries of previous years projects on the web, to give examples for students [PRIME Projects]. The pre-application process, started in 2006, generated 39 pre-applications, resulting in 14 students being accepted into the program.Aggressive recruiting is required to assure gender parity. Because no female undergraduates applied during our first pilot year, we partnered with the Society of Women Engineers and key campus administrators to get the word out. Applications from women and thus acceptance of women into the program grew in years 2 and 3 until in year 3 more than half (8 out of 14) were women.Previous students are effective recruiters. We include previous program participants in all information sessions. Students gain confidence to apply when listening to peers. PRIME alumni are especially effective in encouraging other (especially female) students to apply [Wu06] (Wu participated in PRIME 2006).

**Remarkable Loop Flexibility in Avian Influenza N1 and Its Implications for Antiviral Drug Design Rommie E. Amaro, David D. L. Minh, Lily S. Cheng, William M. Lindstrom, Jr., Arthur J. Olson, Jung-Hsin Lin, Wilfred W. Li, and J. Andrew McCammon J. Am. Chem. Soc.; 2007; ASAP Web Release Date: 01-Jun-2007; (Communication) DOI: 10.1021/ja0723535 *Google Pacific Rim Experiences youtubewww.youtube.com/?v=4lY6x0S3IoA**Page 186 NSF FY07 report, released 6 Feb 06http://www.nsf.gov/about/budget/fy2007/pdf/fy2007.pdf

**PRIME is a model program that draws upon expertise across the UCSD campus to promote a new type of international research apprenticeship and experiential cultural training with the goal of preparing student to compete successfully in the global workforce. Our goal is to encourage a broad a participation as possible, keeping standards high and barriers low. The program has attracted students from the Natural Sciences, Engineering, and elsewhere. Having a record of the research and learning experience as part of the transcript has been a hallmark of this model as well as a significant factor in helping students post graduation. As such, it is worth pointing out that most students in the program do not need more credits, they need the single credit.

**With the President of Osaka UniversityLeft to Right: Susumu Date, Shinji Shimojo, Marshall Levesque, Cathy ChangHideo Miyahara, Daniel Goodman, Robert Sy, Kohe Ishikawa, Peter Arzberger.Cathy, Daniel and Marshall worked on aspects of modeling different proteins; Roberthelped construct a tile display wall.

Lao She Tea House:Front (l-b): Lily Cheng, Elaine Liu,Lisa Zhao; Back: Peter Arzberger, Trina McMahon; Tim Kratz (U WI); Nan Kai(CNIC Mentor); Fang-Pang Lin (NCHC)Lily and Lisa worked on aspects of modeling Avian flu; Lisa used tile displaywall to explore astronomy data from Beijing Astronomy.

In MelbourneLeft to Right: Celia Croy, Iwen Wu, Noah Ollikainen, Angelina AltschulerAngelina and Iwen worked as aspects of cardiacmodeling; Celia conducted computational analysis of biological structure; Noah conducted virtual screening of drugs

Touring the new NCHC Building in TaichungLeft to Right: Mahboubeh Hashemi, Peter Arzberger,Bryan Lin, Stephen ChenMahboubeh and Stephen worked on adopting edge detecting algorithm to neuroscience application with Prof. G Silva, Bioenginnering; Bryan worked on experiementwith decommissions school house.