principles of immunology immunodeficiency 4/20/06 ”wise people talk because they have something to...
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![Page 1: Principles of Immunology Immunodeficiency 4/20/06 ”Wise people talk because they have something to say; fools, because they have to say something” Plato](https://reader035.vdocument.in/reader035/viewer/2022062516/56649d625503460f94a44e08/html5/thumbnails/1.jpg)
Principles of Immunology
Immunodeficiency4/20/06
”Wise people talk because they have something to say; fools, because they have to say something”
Plato
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Word/Terms List
AIDS SCID Primary immunodeficiency Secondary immunodeficiency
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Immunodeficiency
Primary-usually genetic, congenital
Secondary-Acquired
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Mechanisms of Immunodeficiency
Loss or reduction of: Cell type Cell numbers Cell function
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Loss of Cell Function
Receptors Cell signaling Cytokine production Ig production Co stimulation impairment Intracellular killing Extravasation impairment
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Primary Immunodeficiency Myeloid lineage
Congenital agranulocytosis Leukocyte-adhesion deficiency
Lymphoid lineage Severe combined immunodeficiency (SCID) B cells
Agammaglobulinemia Hypogammaglobulinemia Specific Ig Deficiencies
T cells DiGeorge Syndrome Wiskott Aldrich Syndrome
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Secondary Immunodeficiency
Drug related Disease related
Cancer AIDS
HIV T helper cell as target
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SCID
Various genetic defects No TCR or defective TCR Defective cell signaling Defective IL 2
Recurrent infections Death at early age
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Wiskott Aldrich Syndrome X linked disorder Affects platelet numbers/function Affects T cell function Cytoskeleton of lymphocytes affected
Lower amounts of IgM Increased susceptibility to certain
bacterial infections
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Bruton’s Agammaglobulinemia
Low levels of IgG B cell signal transduction affected Defective BCR
Recurrent bacterial diseases starting at end of first year of life
Short life span
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DiGeorge Syndrome
Poorly developed or functioning thymus
Associated with other developmental conditions
Depression of T cell numbers Absence of T cell response Humoral response to T independent
antigens only
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Secondary Immunodeficiency
Drugs Irradiation Cancer AIDS
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AIDS
HIV as agent T helper as target cell Attacked by own CD8 cells Susceptible to opportunistic infections
Kaposi’s sarcoma CMV Candida Pneumocystis carinii