December 2015

Probiotics: Clinical effects and proposed mechanisms

Lactic acid bacteria and their impact on health -the views of Élie Metchnikoff

Russian scientist and Nobel laureate Élie Metchnikoff, who in the beginning of the 20th century suggested that it would be possible to modify the gut flora and to replace harmful microbes with useful microbes.Metchnikoff, at that time a professor at the Pasteur Institute in Paris, proposed that the aging process results from the activity of putrefactive (proteolytic) microbes producing toxic substances in the large bowel.Metchnikoff had observed that certain rural populations in Europe, for example in Bulgaria and the Russian steppes who lived largely on milk fermented by lactic-acid bacteria were exceptionally long lived.

2E. Metchnikoff, 1907

What are probiotics?

The characteristics of probiotics should include the following:• Lack pathogenicity• Be robust enough to withstand external processing• Survive on the shelf• Be viable in the gastrointestinal environment• Adhere to the gastrointestinal epithelium• Produce antimicrobial substances• Modulate the host immune response and metabolism

Source: Tappenden et al; 2010 3

Probiotics are live microorganisms, which, when administered in adequate amount confer a health benefit to the host.

Joined FAO/WHO definition, 2001.

DuPont™ Danisco® premium probiotics… Provided as single strains, blends, finished formats and HOWARU® branded franchise…

NCFM51%

HN0199%

HN0019%

B4207%

Bi-078%

Bl-046%Lpc-37

3%La-143%

Lr-321%

Ls-333%

Over 600 published papersA large contribution to probiotic scientific background

Reported clinical benefits AllergiesEczemaFunctional Bowel Disorders and digestive disturbancesInfectious diarrhea

Thank you!To know more please write to kiran.punjabi@dupont.com