product recovery
TRANSCRIPT
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SEMINAR
ANKUSH MEENA
B100974CH
DEPATMENT OF CHEMICAL ENGINEERING
NATIONAL INSTITUTE OF TECHNOLOGY CALICUT
12/03/2014
PRODUCT RECOVERY
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The Product recovery operation are also known as downstream processing steps.
Product recovery in bioprocessing plays a vital role.
Introduction
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Downstream- ‘After the fermentation process’.
Primary ‘unit operations’ of Downstream Processing
Cell recovery /removal Dewatering
What is downstream Processing
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Secondary ‘unit operations’ Protein purification
Adsorption chromatography Protein processing
Immobilisation Prilling
Protein packaging Sterilisation etc
Downstream processing
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The cell disruption techniques may be classified as• Physical method • Chemical method
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The following unit operations are used for the separation of solids : • Filtration • Sedimentation • Centrifugation • Foam Separation• Precipitation
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System Type With phase change
Without phase change
Solid-liquid Soluble Drying, Evaporation,Adsorption
Ultrafiltration, Reverse osmosis
Insoluble Drying Filtration, Sedimentation ,
Liquid-liquid Soluble Distillation Chromatography
Insoluble Extraction Centrifugation
Solid-solid immiscible Selective Solubilisation
Air Separation ScreeningsievingMiscible Cell disruption
Liquid-liquid-solid
Miscible Immiscible
Adsorption Centrifugation Sedimentation Decanting
Various unit operation in bioprocessing for separation of different phase
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It is based on the differences in the surface activity.
It is chemical process of removing a component of a liquid mixture using a bubbled gas and a surfactant to collect the material.
Wastewater treatment systems often use foam separation steps to remove solids from the water stream.
Foam Separation
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Foam separation diagram
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It is also a very useful method for product recovery by adding the precipitation agent .
The compounds from the corresponding salts or the suspending solids which would settle down to the bottom.
This method is extensively used for product recovery of protein isolates or protein concentrates from oil seeds
Precipitation
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Filtration is a physical or mechanical process to separate solids particle from fluids.
Filtration is a technique used for two main purposes.
The first is to remove solid impurities from a liquid.
The second is to collect a desired solid from the solution.
It is a very effective and convenient method of separating the suspending solids from the slurries .
The fluid that pass through is called a filtrate.
Filtration
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Filtration is used to separate particles and fluid in a suspension, where the fluid can be a liquid, a gas or a supercritical fluid.
Filtration, as a physical operation is very important in chemistry for the separation of materials of different chemical composition.
Filtration is also important and widely used as one of the unit operations of chemical engineering.
Application of filtration
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pressure drop Viscosity of filtrate Area of filtering surfaceResistance of filtrate cake Resistance of filtrate surface Properties of slurry
Factor affected on filtration
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Filters are divided into three main categories 1. Cake filters2. Clarifying filters3. Cross-flow filters
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Slurries with high solid concentration are operated in cake filters.
Very dilute liquids are passed through the clarifying filters.
The cross-flow filters are used for concentrating the solutions by using filtration technique.
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Cross-flow filters
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Thank you