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Curriculum Vitae 1 Prof Yajnik Chittaranjan Sakerlal King Edward Memorial Hospital. Diabetes Unit. Pune- 411011. India. Phone 020-66405731, Fax-020-26111958 [email protected] , [email protected] Date of birth: 31 st January, 1952 Academic Qualifications: M.B.B.S., B.J. Medical College, Pune (India) 1976 M.D. (Medicine), B.J. Medical College, Pune (India) 1980. FRCP, Royal College of Physicians, London (UK) 2004.

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Curriculum Vitae

 

 

Prof Yajnik Chittaranjan Sakerlal

King Edward Memorial Hospital.

Diabetes Unit. Pune- 411011. India.

Phone 020-66405731, Fax-020-26111958

[email protected], [email protected]

Date of birth: 31st January, 1952

Academic Qualifications:

M.B.B.S., B.J. Medical College, Pune (India) 1976

M.D. (Medicine), B.J. Medical College, Pune (India) 1980.

FRCP, Royal College of Physicians, London (UK) 2004.

Curriculum Vitae

 

 

Other Trainings:

Trained in clinical diabetology, and research methodology in diabetes, at the Sheikh

Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, UK, 1981-1984

Royal Society of Medicine Fellowship for training in Genetics, at Department of

Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK, 2001

Fellowship in the Department of Obstetrics, Adelaide Women and Children’s Hospital,

Adelaide, Australia, 2003

Commonwealth Fellowship, Academic Department of General Practice, Leicester, UK,

2003.

Fellowship in the department of epidemiology at the London School of Hygiene and

Tropical Medicine, 2003.

GCP-ICH advanced course, Vienna University, 2006

Current and Recent Positions:

Member of Wellcome Trust, Population and Public Health Council. 2009-

Member of Wellcome DBT alliance for career development fellowship. 2009-

Occasional referee: many international and national journals

WHO Expert Group, Life-course approach to prevention of chronic diseases, 2002

WHO Expert Committee on Definition of Obesity in Asians, 2003

Centre Head for HOPE; a training programme of International Diabetes Federation for

diabetes educators ( 400 educators to be trained in 2 years), 2010

Member, Steering Committee, United Nations University and Asian Development

Bank for capacity building for nutrition research and services in Asia. (CASNA).

2003- 2007

Chair, the subcommittee of the International Union of Nutritional Sciences on the

developmental origins of adult disease (DOHaD) 2003-2007

Member, Research Advisory Committee, National Institute of Nutrition 2006-2009

Member of the task forces of DBT (Dept of Biotechnology, Govt of India)

on ‘Biotechnological Approaches for Food and Nutrition Security’, and

‘Chronic Disease Biology’ 2007-2010

Member, Scientific Advisory Committee, National Institute of Biomedical Genomics

Curriculum Vitae

 

 

(NIBMG) 2010

Founder Member, International Council for research into the Fetal Origins of Adult

Disease (now called DOHAD)

. Honorary Visiting Professor at Peninsula Medical School, Exeter UK

Professional Experience:

Senior Resident, B.J. Medical College, Sassoon Hospitals, Pune. 1977-79

Chief Resident, B.J. Medical College, Sassoon Hospitals, Pune. 1979.

Lecturer. Department of Medicine, B.J. Medical College, Pune. 1980-81

Research Registrar, Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford,

UK. 1981- 1984

Pool Officer of Council of Scientific & Industrial Research, Pune. 1984-87

Visiting Fellow, Diabetes and Vascular Research Centre, Exeter, UK. 2001

Distinguished Visiting Fellow, Dept of Obstetrics & Gynaecology, University of

Adelaide, Adelaide, Australia. 2003

Commonwealth Professional Fellow, University of Leicester, UK. 2003

Visiting Fellow of the Royal Society at the London School of Hygeine and Tropical

Medicine, 2003

Locum Sr. Lecturer to Dr Andrew Hattersley, Peninsula Medical School, UK. 2004

Major Research Projects:

Principal Investigator in the Wellcome Diabetes Study (WDS) – a study of

characterisation of newly diabetic patients in India and their prospective follow

up (since 1987). Now 20 year follow up.

Principal Investigator in Pune Children’s Study (PCS) of the association of birth

weight and glucose tolerance and Insulin resistance at 4 years of age (since

1991). Children studied again at 8years of age and currently at 21 years of age.

Principal Investigator in the intra-uterine growth of babies in rural India in

relation to their mothers' nutrition before and during pregnancy, (PMNS) Pune

Maternal Nutrition Study; (since 1993).

Curriculum Vitae

 

 

Principal Investigator in Coronary Risk of Insulin Sensitivity in Indian Subjects

(CRISIS) study.( 1999- 2001)

Principal Investigator in IAEA- Body composition in Indians by D2O and

Bioimpedence Generated first equation for Bioimpedence in Indians. (1999).

Principal Investigator in the study of relationship between maternal body water

changes and offspring size at birth and its growth in infancy. (2004).

Principal Investigator in a study for Genetic polymorphism affecting triglyceride

metabolism as an independent determinant of insulin resistance and type2

diabetes in Indian patients: Use of Mendelian Randomisation principle

(WELLGEN Study); (since 2005). Described for the first time the association of

TCF7L2, FTO and 32 other genetic polymorphisms. GWAS for T2DM recently

completed.

Principal Investigator to study Effect of Physiological doses of vitamin B12 on 1-

C metabolism (2007-2008).

Principal Investigator in the study of Milk consumption and childhood insulin

resistance (2010-2011).

Principal Investigator in the study of Vitamin B12 absorption in Indians year.

(2007-2008).

Principal Investigator in 33 Clinical trials.

Major research grants:

To characterise and investigate diabetes among Indians in Pune, Wellcome

Trust, UK 1987-1990 £60,821

To characterise and investigate diabetes among Indians in Pune , Wellcome

Trust, UK 1990-1991 £25,000

Glucose tolerance in Indian children in relation to birthweight , Wellcome Trust,

UK 1991-1993 £69,229

The intra-uterine growth of babies in rural India in relation to their mothers’

nutrition before and during pregnancy, Wellcome Trust, UK 1993-1996

£319,920

Curriculum Vitae

 

 

Endocrine, metabolic and cardiovascular correlates of low birthweight in Indian

children – is Syndrome X a sequel of impaired fetal growth? Wellcome Trust,

UK 1995-1997 £102,390

The programming of glucose/insulin metabolism in Indian children. Interim

grant , Wellcome Trust, UK , 1998 £52,300

Total body fat, Proinflammatory Cytokines and Insulin Resistance in Indian

subjects, International Atomic Agency, US$27,000, 1998-2003

Relationship between genetic effects on insulin secretion and insulin action and

intrauterine growth studies in 3 large cohorts, , £18,444, 1998

Relationship of body composition with insulin resistance syndrome in urban &

rural Indians, Nestle Foundation , Switzerland, £215,000, 1999-2003

The maternal origins of type 2 diabetes in India, Wellcome Trust, UK 2000-

2004, £891,036

The relationship of maternal vitamin B12 status to fetal and childhood growth in

India 2003 , Wellcome Trust, £33,054

Relationship between maternal folate and B12 status, size of the offspring at

birth and its growth in infancy. International Atomic Agency. 2003-present

US$27,000

The genetic and environmental influences on plasma triglyceride concentrations

in Indians and their impact on type 2 diabetes, insulin resistance and fetal

growth. , Wellcome Trust, UK, 2004-2007 £128,250

Developmental programming of adiposity and insulin resistance in rural and

urban Indian children, and pilot work to explore its reversibility during

adolescent growth. Wellcome Trust, UK , 2006- 2009. £391,289

Association between maternal Vitamin B12 & folate status pregnancy and

adiposity, insulin resistance and cognitive performance in the offspring at 11

years of age July 2006-June 2008. Department of Biotechnology, New Delhi,

India, INR 77.035 lac

Study of Genetic Susceptibility to Neural Tube Defects and its Association with

Maternal Vitamin B12 and Folate Status Department of Biotechnology, New

Delhi, India, INR 87.8432 lac

Curriculum Vitae

 

 

Efficacy of NaFeEDTA fortified wheat flour on improving anemia and iron status

in school children” June 2007-June 2008, Department of Biotechnology, New

Delhi, India, INR 2137200

Evaluation of oxidative stress in diabetes mellitus", August 2007-August

2009, Department of Biotechnology, New Delhi, India, INR 490,000.

Major honours:

Delivered Hoechst Oration at the Association of Physicians of India. Kathmandu,

1996

Delivered Sam GP Moses oration of the Research Society for Study of Diabetes

in India. Mysore, 1996

Delivered Rajiv Varhadpande Oration, Nagpur, 1997

Delivered Ahuja Memorial Oration, New Delhi, 2001

Lifetime Achievement Award presented by South Asian Society for research in

Atherosclerosis (SASAT). 2006

Delivered DESERT Oration Diabetes Club, Bangalore. 2006

Delivered GS Sainani Oration at APICON, Goa. 2007.

Distinguished Scientist Award by Clinical Ultrasonography in Practice (CUSP):,

2008

Awarded with Hellmut Mehnert award of the International Diabetes Federation,

2009

Achievements:

Established diabetology as a speciality in Pune.

Set up the first centre of excellence in diabetes at KEM hospital Pune. which included

a day care centre (moving away from a old idea of admitting diabetic patients for

control), Created human resources and laboratory infrastructure, and training

programme

Set up first centre of excellence in diabetology research in western India. This includes

a large department with 50 staff members (scientists, clinicians, nutritionists,

biochemists, psychologists and field staff).

Curriculum Vitae

 

 

Set up extensive national and international collaborations for research in diabetes and

intrauterine programming, including those with Sheikh Rashid Diabetes Unit, Oxford,

UK, MRC of UK centre for Developmental Origins of Adult diseases, Department of

Molecular Medicine and Genetics, Exeter, UK,

Described and popularised the concept of thin fat Indians

Set up the first prospective study of normal and diabetic patients (Wellcome Diabetes

Study)

Initiated many studies in life-course evolution of diabetes and cardiovascular diseases

in India

Pioneered a community based study of pre-conceptional enrolment of mothers and life

time follow-up of offspring (Pune Maternal Nutrition Study)

Described regulation of fetal growth and body composition by maternal nutrition and

one- carbon metabolism

Proof of concept community based intervention with physiological doses of vitamin

B12 to reduce plasma homocysteine (as part of primordial prevention studies)

Poised to role out a large community based nutritional intervention in adolescents to

improve the health of next generation

Public engagements to disseminate the research findings highlighting the role

of inter generational risk transmission and dangers of rapid transition.

Expert Reviewer

Journals:

Lancet

Diabetes

Diabetes Care

International Journal of Epidemiology

Quarterly Journal of Medicine

Circulation

American Journal of Physiology

National Medical Journal of India

Journal of Association of Physicians of India

Curriculum Vitae

 

 

International Journal of Diabetes in Developing Countries

Indian Journal of Medical Research

National medical journal of India

Journal of associations of physicians in India

International journal of diabetes in developing countries

Indian journal of medical research

Membership of professional societies:

1. Research Society for Study of Diabetes in Indians

2. Association of Physicians of India

3. British Diabetic Association

4. European Association for Study of Diabetes

5. International Diabetes Federation

6. New York Academy of Sciences

7. American Diabetes Association

8. American Society of Nutritional Sciences.

9. Society for Natal Effects on Health of Adults (SNEHA)

10. Developmental Origins of Health and Disease (DOHaD)

11. Royal College of Physicians

Special invitations:

1st World Congress on Prevention of Diabetes and its Complications, Copenhagen

1996.

6th Cambridge Seminar on the Epidemiology and Public Health aspects of Diabetes

Mellitus, Cambridge 1996.

State of Art Symposium: Intrauterine Malnutrition - Long-term consequences in the off-

spring, EASD-96, Vienna. Intra-uterine Nutrition: A Risk Factor for Diabetes.

International Diabetes Federation, Helsinki, 1997.

International Symposium on Nutrition Related Chronic Diseases in Asia, Asian

Nutrition Forum and WHO, New Delhi, 1997.

Curriculum Vitae

 

 

Wellcome-WHO meeting on Malnutrition Related Diabetes Mellitus,London 1988

The role of intrauterine growth and nutrition in the development of diabetes and

obesity: 4th IDF Western Pacific Regional Congress, Sydney, Australia. August 1999.

Coordinated Research Programme meeting on 'Application of Nuclear Techniques in

the Prevention of Degenerative Disease (Obesity & Non Insulin Dependent Diabetes),

International Atomic Energy Agency (IAEA), Vienna, Austria, May 1999.

Abdominal Obesity in Indians, the risks and origins: 8th Asian Nutrition Congress at

Seoul, Korea. August 1999.

Summer meeting of Nutrition Society, University of Glasgow, Glasgow, June 1999.

4th IDF Western Pacific Regional Congress, Sydney, Australia. August 1999.

Symposium on ‘Fetal Origins of Adult Cardiovascular Disease: New Directions’,

Harvard Medical school, Boston, USA, November 1999.

Insulin Resistance programming, Genetic or Environmental: International conference

of heart and health in developing countries. New Delhi

Childhood antecedents of type 2 diabetes. International Diabetes Federation

Congress, Mexico City, November 2000

The fetal origins of coronary heart disease and diabetes in developing countries. 1st

world congress on the ‘Fetal Origins of Adult Disease’. Mumbai, India, February 2001

WHO expert meeting on Life Course and Health, Geneva, Switzerland, May 2001

Coordinated Research Programme meeting on 'Application of Nuclear Techniques in

the Prevention of Degenerative Disease (Obesity & Non Insulin Dependent Diabetes),

Jamaica, June 2001

WHO expert consultation on appropriate BMI for Asian population and its implications

for policy and intervention strategies. Singapore, July 2002.

Principal speaker, Australian Diabetes in Pregnancy Annual meeting, Akaroa, New

Zealand, March 2002

3rd World Congress on Prevention of Diabetes and its Complications, Hong Kong 2002

International Diabetes Federation and WHO workshop on ‘Type 2 diabetes in children’,

Santa Monica, Feb. 2003

Symposium on ‘Critical evaluation of fetal origins hypothesis and its implications for

developing countries’. FASEB meeting, Santiago, USA, April 2003.

Experimental Biology Meeting, San Diego, USA, April 2003

Curriculum Vitae

 

10 

 

Nutrition Society Meeting as part of 2nd world Congress on the ‘Fetal Origins of Adult

Disease’. Brighton, UK, June 2003.

NIH Meeting on Maternal Nutrition, Washington DC, USA, November 2004.

American Diabetes Association, June 2004

Nestle Foundation Nutrition Symposia, China, May 2004

New Zealand Diatetics Association, September 2004

Sixth International Conference on Preventive Cardiology. Iguacu, Brazil May.

National Summit on Preconception Care, Atlanta, USA. 21-22nd June, 2005

18th International Congress of Nutrition. Durban, South Africa, September 2005.

Keynote address on ‘Metabolic syndrome: A case for phasic nutritional insult’

Marabou Symposium, June 2005.

National Summit on Preconception Care, Atlanta, USA. June, 2005

32nd Annual meeting of Fetal and Neonatal Physiological Society, Adelaide, Australia.

September, 2005. Talk at Jeffery Robinson Symposium on ‘Maternal Nutrition and

offspring cardiovascular risk’.

Third International Congress on Developmental origins of Health & disease. Toronto,

Canada, November,2005. Symposium: Metabolism in Pregnancy. Talk on ‘Fetal

Origins of Insulin Resistance and Adiposity in South Asians’

Meeting of Society for Gynecologic Investigation, Toronto, Canada March 2006. Talk

tittle:-Diabetes epidemic in Indians. A vitamin imbalance syndrome?

DIPSI. Pregnancy & Diabetes meeting in Chennai Feb. 2006

RSSDI meeting - Pune April 2006.

10th International Congress on Obesity ICO 2006, Sydney Australia, September

2006

MAPICON ( Maharashtra Chapter of API Conf.) Aurangabad October,2006

IDF – 19th World Diabetes Congress Johannesburg, Capetown,

December2006

5th Wnter Symposium – Christian Medical College, Vellore January 2007.

APICON Panji – Goa February 2007

4th International Symposium on Diabetes and Pregnancy Istanbul , Turkey 2006.

Prediabetes and Metabolic syndrome- Barcelona- Spian. April 2007.

Curriculum Vitae

 

11 

 

“Advanced GCP for experts in Clinical Research” organized by Vienna School

of Clinical Research(VSCR). New Delhi May 2007.

Epigenetic Mechanisms in Obesity: Research and Public Health implications

Baton Rouge – Lousiana. May 2007.

Symposium on Nutrition and Bone Health at IIC New Delhi. July 2007

Post Graduate Steensen Summer School, University of Copenhagen and Steno

Diabetes Center, Denmark September 2007.

43rd annual meeting of EASD in Amsterdam. September 2007.

Third and Final Research Coordination meeting of IAEA- Vienna – Austria.

October 2007.

Wellcome Trust Meeting China. November 2007.

Teaching Seminar on Research Methods in Nutrition New Delhi November 2007.

NEOCON, AFMC, Pune. December 2007.

Nestle, New Delhi March.

Round Table on Women and Diabetes at the UN, New York.

5th Asia-Oceania Conference of Perinatology in Nagoya, Japan May 2008.

5th World Congress on Prevention of Diabetes and its Complications. June

2008.

ISPAD 2008,Durban August 2008.

IAEA Technical Meeting on"Body Composition from Conception through

Infancy", Vienna. September 2008.

IEA congress ,Southern Brazil (Porto Alegre) September 2008.

Clinical Ultrasonography in Practice (CUSP), Chennai September 2008.

Consensus on Prevention of T2DM - Primarand Secondary Developed by IDF –

SEAR,DASG Kathmandu, Nepal October 2008.

Diabetes in Asia Study Group Conference October 2008 Theme:

Implementation of Primary Prevention Strategies for Type 2 Diabetes

ICE meeting, Childhood obesity: contribution of maternal factors. Brazil.

November 2008

"Steno - ROFE Diabetes Symposium; Update in Diabetes Research and

Clinical Diabetology" Kuala Lumpur November 2008.

Curriculum Vitae

 

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NEONATAL UPDATE 2008“The science of newborn care” November

2008.

WDF Summit 2008, Chennai November 2008.

ICMR-CIHR workshop on Childhood Obesity and NCDs

Asia Oceania Conference on Obesity. Mumbai. February 2009

DIPSI, Chennai Vitamins and Gestational Diabetes Mellitus February 2009.

Indo- US Diabetes Coalition New Delhi February 2009.

5th International Symposium on Diabetes and Pregnancy

Sorrento, Italy March 2009.

3rd International Congress on Prediabetes and the Metabolic Syndrome April

2009

The Danish International Development Assistance (Danida) and the World

Diabetes Foundation (WDF) are organising a Conference on Non-

Communicable Diseases (NCDs) April 2010.

GDM Task force meeting - at ICMR HQRS April 2010.

American Diabetes Association, Orlando, Florida June 2010.

11th International Congress on Obesity Stockholm, Sweden. July 2010

NNI satellite symposia International Pediatric association Congress in

Johannesburg. August 2010

Unliver SPARK Symposium. Singapore September 2010

MISACON 2010 Maharashtra state chapter conference of Anaesthesiologists

at Nasik. 2010

Society for Natal Effects on Health of Adults. (SENHA); Meeting November

2010.

"Fetal Growth Restriction and its Consequences" being organized by the

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi

November. 2010

Wellcome DBT February 2010

Curriculum Vitae

 

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Publications:

1. Yajnik CS, Smith RF, Hockaday TD, Ward NI. Fasting plasma magnesium

concentrations and glucose disposal in diabetes. Br Med J (Clin Res Ed)

1984;288:1032-4.

2. Yajnik CS, Special topic: Malnutrition related diabetes mellitus- Diagnosis and

treatment. Diabetologia 28:708, 1985.

3. Shelgikar KM, Kanitkar SV, Naik SS, Yajnik CS, Alberti KGMM, Hockaday TDR.

Are fibrocalculous pancreatic daibetiec more insulin-sensitive than insulin

depandent diabetics? Diabetes Bulletin 1988; 8:28-31.

4. Patole AP, Lawate US, Raut KN, Sheglekar KM, Yajink CS, Nutritional intak of

young diabetics. Diabetes bulletin 1988; 8:43-48.

5. Yajnik CS. Treatment of malnutrition related diabetes mellitus. Proceedings of a

WHO-Wellcome Symposium. London, June 1988 (Eds Alberti KGMM, Keen H)

Oxford University Press

6. Yajnik CS, Katrak A, Kanitkar SV, Naik SS, D'Souza V, Dandona P. Serum

immunoreactive trypsin in tropical pancreatic diabetes syndrome. Ann Clin

Biochem 1989;26 ( Pt 1):69-73.

7. Yajnik CS. Diabetes in tropical-developing countries. Diabetes Annual 5, 1990;

72-87.

8. Coppack SW, Yajnik CS, Doll HA, Thursfield V, Hockaday TD. The metabolic

associations of intravenous glucose tolerance in the 10 years from diagnosis of

type 2 diabetes. Diabet Med 1990;7:718-25.

9. Yajnik CS, Shelgikar KM, Sahasrabudhe RA et al. The spectrum of pancreatic

exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis.

Diabetologia 1990;33:417-21.

10. Yajnik CS, Kanitkar SV, Shelgikar KM, Naik SS, Alberti KG, Hockaday D.

Pancreatic C-peptide response to oral glucose in fibrocalculous pancreatic

diabetes. Improvement after treatment. Diabetes Care 1990;13:525-7.

11. Yajnik CS, Sahasrabudhe RA, Naik SS et al. Exocrine pancreatic function (serum

immunoreactive trypsin, fecal chymotrypsin, and pancreatic isoamylase) in Indian

diabetics. Pancreas 1990;5:631-8.

Curriculum Vitae

 

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12. Shelgikar KM, Hockaday TD, Yajnik CS. Central rather than generalized obesity

is related to hyperglycaemia in Asian Indian subjects. Diabet Med 1991;8:712-7.

13. Yajnik CS. Diabetes in tropical developing countries. Diabetes Annual/6

1991; 62-81

14. Yajnik CS, Naik SS, Raut KN et al. Urinary albumin excretion rate (AER) in

newly-diagnosed type 2 Indian diabetic patients is associated with central obesity

and hyperglycaemia. Diabetes Res Clin Pract 1992;17:55-60.

15. Yajnik CS, Shelgikar KM, Naik SS et al. The ketosis-resistance in fibro-calculous-

pancreatic-diabetes. 1 Clinical observations and endocrine-metabolic

measurements during oral glucose tolerance test. Diabetes Res Clin Pract

1992;15:149-56.

16. Yajnik CS. Diabetes secondary to tropical calcific pancreatitis. Bailliere's Clinical

Endocrinology & Metabolism 1992; 6:777-796

17. Yajnik CS, Naik SS, Bhat DS et al. The relationship between obesity, plasma

immunoreactive insulin concentration and blood pressure in newly diagnosed

Indian type 2 diabetic patients. Diabet Med 1993;10:146-51.

18. Yajnik CS, Shelgikar KM. Fibrocalculous pancreatic diabetes in Pune, India.

Clinical features and follow-up for 7 yr. Diabetes Care 1993;16:916-21.

19. Yajnik CS. Secondary Diabetes. Diabetographia, 14, 1993

20. Shelgikar KM, Yajnik CS Mohan V. Complications in Fibro-calculus pancreatic

diabetes- The Pune and Madras experience. Int. J. Deab. Dev. Countries

(1995), vol. 15.

21. Yajnik CS, Fall CHD, Vaidya U, Pandit AN, Bavdekar A, Bhat DS, Osmond C,

hales CN, Barker DJP. Fetal growth and glucose and insulin metabolism in four

year old Indian children. Diabetic Medicine 1995; 12:330-336

22. Fall CHD, Pandit AN, Law CM, Yajnik CS, Clark P, Breier B, Osmond C, Shiell

AW, Gluckman PD, Barker DJP. Size at birth and plasma insulin-like growth

factor-1 concentrations in childhood. Archives of Disease in Childhood 1995; 73:

287-29

23. Clark A, de Koning EJ, Hattersley AT, Hansen BC, Yajnik CS, Poulton J.

Pancreatic pathology in non-insulin dependent diabetes (NIDDM). Diabetes Res

Clin Pract 1995;28 Suppl:S39-S47.

Curriculum Vitae

 

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24. Rao RH, Yajnik CS. Commentary: time to rethink malnutrition and diabetes in the

tropics. Diabetes Care 1996;19:1014-7.

25. Shelgikar KM, Naik SS, Khopkar M et al. Circulating lipids and cardiovascular risk

in newly diagnosed non-insulin-dependent diabetic subjects in India. Diabet Med

1997;14:757-61.

26. Yajnik CS. The insulin resistance epidemic in India: small at birth, big as adult?

IDF Bulletin 1998; 43:23-28

27. Yajnik CS, Sardesai BS, Bhat DS et al. Ketosis resistance in fibrocalculous

pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides.

Metabolism 1997;46:1-4.

28. Mohan V, Nagalotimath SJ, Yajnik CS, Tripathy BB. Fibrocalculous pancreatic

diabetes. Diabetes Metab Rev 1998;14:153-70.

29. Yajnik CS. Foetal solutions to a fatal epidemic: the relevance in India. Natl Med J

India 1998;11:53-5.

30. Bavdekar A, Yajnik CS, Fall CH et al. Insulin resistance syndrome in 8-year-old

Indian children: small at birth, big at 8 years, or both? Diabetes 1999;48:2422-9.

31. Yudkin JS, Yajnik CS, Mohamed-Ali V, Bulmer K. High levels of circulating

proinflammatory cytokines and leptin in urban, but not rural, Indians. A potential

explanation for increased risk of diabetes and coronary heart disease. Diabetes

Care 1999;22:363-4.

32. Kinare AS, Natekar AS, Chinchwadkar MC et al. Low midpregnancy placental

volume in rural Indian women: A cause for low birth weight? Am J Obstet

Gynecol 2000;182:443-8.

33. Yajnik C. Interactions of perturbations in intrauterine growth and growth during

childhood on the risk of adult-onset disease. Proc Nutr Soc 2000;59:257-65.

34. Ramachandran A, Snehalatha C, Kapur A et al. High prevalence of diabetes and

impaired glucose tolerance in India: National Urban Diabetes Survey.

Diabetologia 2001;44:1094-101.

35. Merezak S, Hardikar AA, Yajnik CS, Remacle C, Reusens B. Intrauterine low

protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective

role of taurine. J Endocrinol 2001;171:299-308.

Curriculum Vitae

 

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36. Rao S, Yajnik CS, Kanade A et al. Intake of micronutrient-rich foods in rural

Indian mothers is associated with the size of their babies at birth: Pune Maternal

Nutrition Study. J Nutr 2001;131:1217-24.

37. Refsum H, Yajnik CS, Gadkari M et al. Hyperhomocysteinemia and elevated

methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian

Indians. Am J Clin Nutr 2001;74:233-41.

38. Yajnik CS. The insulin resistance epidemic in India: fetal origins, later lifestyle, or

both? Nutr Rev 2001;59:1-9.

39. Yajnik CS. Commentary: Fetal origins of cardiovascular risk-nutritional and non-

nutritional. Int J Epidemiol 2001;30:57-9.

40. Yajnik CS, Coyaji KJ, Joglekar CV, Kellingray S, Fall C. Paternal insulin

resistance and fetal growth: problem for the 'fetal insulin' and the 'fetal origins'

hypotheses. Diabetologia 2001;44:1197-8.

41. Fall, Yajnik, Rao, Coyaji, Shier. The effects of meternal body composition before

pregnancy on fetal growth: the Pune Maternal Nutrition and Fetal Growth study,

Book chapter 21.

42. Yajnik CS. The lifecycle effects of nutrition and body size on adult adiposity,

diabetes and cardiovascular disease. Obesity Reviews 2002; 3:217-224

43. Lubree HG, Rege SS, Bhat DS et al. Body fat and cardiovascular risk factors in

Indian men in three geographical locations. Food Nutr Bull 2002;23:146-9.

44. Yajnik CS, Lubree HG, Rege SS et al. Adiposity and hyperinsulinemia in Indians

are present at birth. J Clin Endocrinol Metab 2002;87:5575-80.

45. Yajnik, Author’s reply to Murpy, Diabetologia 2002: 45: 596-7

46. Fall CH, Yajnik CS, Rao S, Davies AA, Brown N, Farrant HJ. Micronutrients and

fetal growth. J Nutr 2003;133:1747S-56S.

47. Hockaday TD, Yajnik CS. --to: Hales CN, Barker DJP (1992) Type 2 (non-insulin-

dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia

35:595-601. Diabetologia 2003;46:303-4.

48. Rao S, Kanade A, Margetts BM et al. Maternal activity in relation to birth size in

rural India. The Pune Maternal Nutrition Study. Eur J Clin Nutr 2003;57:531-42.

49. Yajnik CS, Fall CHD, Coyaji KJ, Hirve SS, Rao S, Barker DJP, Joglekar C,

Kellingray S. Neonatal anthropometry: The thin-fat Indian baby, The Pune

Maternal Nutrition Study. International Journal of Obesity 2003; 26:173-180.

Curriculum Vitae

 

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50. Yajnik CS. Nutrition, growth and body size in relation to insulin resistance and

type 2 diabetes. Current Diabetes Reports 2003; 3:108-114.

51. Yajnik CS, Shelgikar KM, Naik SS et al. Impairment of glucose tolerance over 10

years in middle-aged normal glucose tolerant Indians. Diabetes Care

2003;26:2212-3.

52. Yajnik CS, Joglekar CV, Pandit AN et al. Higher offspring birth weight predicts the

metabolic syndrome in mothers but not fathers 8 years after delivery: the Pune

Children's Study. Diabetes 2003;52:2090-6.

53. Harper PR, Sayyad MG, Senna V, Shahani AK, Yajnik CS, Shelgikar KM. A

system modeling approach for the prevention and treatment of diabetic

retinopathy. Europen Journal of Operations research 2003, 150:81-91.

54. Yajnik CS, Editorial, International Journal of diabetes in developing countries.

Jan-Mar-1993.

55. Hanson M, Gluckman P, Bier D et al. Report on the 2nd World Congress on Fetal

Origins of Adult Disease, Brighton, U.K., June 7-10, 2003. Pediatr Res

2004;55:894-7.

56. Kale SD, Yajnik CS, Kulkarni SR et al. High risk of diabetes and metabolic

syndrome in Indian women with gestational diabetes mellitus. Diabet Med

2004;21:1257-8.

57. Appropriate body mass index for Asian populations and its implications for policy

and intervention strategies, WHO expert consultation, Lancet, 2004, 363: 157-

163.

58. Yajnik CS, Yudkin JS. Y-Y paradox. Lancet 2004, 363:163

59. Yajnik CS. Individuals born in the USA in the year 2000 have a 1 in 3 risk pf

contracting diabetes mellitus in their lifetime. Evidence-based Healthcare, 2004,

8:80-81

60. Yajnik CS. Fetal origins of adult disease, where do we stand? Int. J. Diab. Cev,

Countries (2001), VOL. 21

61. Rush E, Plank L, Chandu V et al. Body size, body composition, and fat

distribution: a comparison of young New Zealand men of European, Pacific

Island, and Asian Indian ethnicities. N Z Med J 2004;117:U1203.

62. Yajnik CS. Size and body composition at birth and risk of type-2 diabetes. Nestle

Nutr Workshop Ser Pediatr Program 2005;55:169-78.

Curriculum Vitae

 

18 

 

63. Yajnik CS, Association of birth weight with glucose and insulin metabolism in

4year old Indian children. Novo Nordisk Diabetes Update 1994. Kapur A. Ed,

health care communications

64. Bhat DS, Yajnik CS, Sayyad MG et al. Body fat measurement in Indian men:

comparison of three methods based on a two-compartment model. Int J Obes

(Lond) 2005;29:842-8.

65. Joshi NP, Kulkarni SR, Yajnik CS et al. Increasing maternal parity predicts

neonatal adiposity: Pune Maternal Nutrition Study. Am J Obstet Gynecol

2005;193:783-9.

66. Yajnik CS. Obesity epidemic in India: intrauterine origins? Proc Nutr Soc

2004;63:387-96.

67. Knight B, Shields BM, Turner M, Powell RJ, Yajnik CS, Hattersley AT. Evidence

of genetic regulation of fetal longitudinal growth. Early Hum Dev. 2005

81(10):823-831

68. Yajnik CS, Deshpande SS, Panchanadikar AV, Naik SS, Deshpande JA, Coyaji

KJ, Fall C, Refsum H. Maternal total homocysteine concentration and neonatal

size in India. Asia Pacific Journal of Clinical Nutrition, 2005;14 (2):179-81.

69. Yajnik CS. Early life origins of insulin resistance and type 2 diabetes in India and

other Asian countries. J Nutr 2004;134:205-10.

70. Kale SD, Kulkarni SR, Lubree HG et al. Characteristics of gestational diabetic

mothers and their babies in an Indian diabetes clinic. J Assoc Physicians India

2005;53:857-63.

71. Kanade AN, Rao S, Yajnik CS, Margetts BM, Fall CH. Rapid assessment of

maternal activity among rural Indian mothers (Pune Maternal Nutrition Study).

Public Health Nutr 2005;8:588-95.

72. Chandak GR, Ward KJ, Yajnik CS et al. Triglyceride associated polymorphisms

of the APOA5 gene have very different allele frequencies in Pune, India

compared to Europeans. BMC Med Genet 2006;7:76.

73. Ganpule A, Yajnik CS, Fall CH et al. Bone mass in Indian children--relationships

to maternal nutritional status and diet during pregnancy: the Pune Maternal

Nutrition Study. J Clin Endocrinol Metab 2006;91:2994-3001.

Curriculum Vitae

 

19 

 

74. Leary S, Fall C, Osmond C et al. Geographical variation in relationships between

parental body size and offspring phenotype at birth. Acta Obstet Gynecol Scand

2006;85:1066-79.

75. Leary S, Fall C, Osmond C, Lovel H, Campbell D, Eriksson J, Forrester

T,Godfrey K, Hill J, Jie M, Law C, Newby R, Robinson S, Yajnik C. Geographical

variation in neonatal phenotype. Acta Obstet Gynecol Scand. 2006;85(9):1080-

1089.

76. Shields BM, Knight B, Turner M et al. Paternal insulin resistance and its

association with umbilical cord insulin concentrations. Diabetologia

2006;49:2668-74.

77. Ward KJ, Ellard S, Yajnik CS et al. Allelic drop-out may occur with a primer

binding site polymorphism for the commonly used RFLP assay for the -1131T>C

polymorphism of the Apolipoprotein AV gene. Lipids Health Dis 2006;5:11.

78. Yajnik C. Nutritional control of fetal growth. Nutr Rev 2006;64:S50-S51.

79. Yajnik CS, Deshpande SS, Lubree HG et al. Vitamin B12 deficiency and

hyperhomocysteinemia in rural and urban Indians. J Assoc Physicians India

2006;54:1-8

80. Chandak GR, Janipalli CS, Bhaskar S et al. Common variants in the TCF7L2

gene are strongly associated with type 2 diabetes mellitus in the Indian

population. Diabetologia 2007;50:63-7.

81. Hockaday D, Sayyad M, Yajnik C. Counterpoint: appreciating homeostasis model

assessment: more useful earlier rather than later. Diabetes Care 2007;30:2414-8.

82. Yajnik CS. Growth and nutrition in early life and risk of type 2 diabetes.

International Diabetes Monitor. 2007; 19:1-8.

83. Joglekar CV, Fall CH, Deshpande VU et al. Newborn size, infant and childhood

growth, and body composition and cardiovascular disease risk factors at the age

of 6 years: the Pune Maternal Nutrition Study. Int J Obes (Lond) 2007;31:1534-

44.

84. Kulkarni SR, Fall CH, Joshi NV et al. Determinants of incident hyperglycemia 6

years after delivery in young rural Indian mothers: the Pune Maternal Nutrition

Study (PMNS). Diabetes Care 2007;30:2542-7.

Curriculum Vitae

 

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85. Pathak P, Kapil U, Yajnik CS, Kapoor SK, Dwivedi SN, Singh R. Iron, folate, and

vitamin B12 stores among pregnant women in a rural area of Haryana State,

India. Food Nutr Bull 2007;28:435-8.

86. Rush EC, Plank LD, Yajnik CS. Interleukin-6, tumour necrosis factor-alpha and

insulin relationships to body composition, metabolism and resting energy

expenditure in a migrant Asian Indian population. Clin Endocrinol (Oxf)

2007;66:684-90.

87. Yajnik CS, Lubree HG, Thuse NV et al. Oral vitamin B12 supplementation

reduces plasma total homocysteine concentration in women in India. Asia Pac J

Clin Nutr 2007;16:103-9.

88. Watve MG, Yajnik CS. Evolutionary origins of insulin resistance: a behavioral

switch hypothesis. BMC Evol Biol 2007;7:61.

89. Yajnik CS, Godbole K, Otiv SR, Lubree HG. Fetal programming of type 2

diabetes: is sex important? Diabetes Care 2007;30:2754-5.

90. Bhate V, Deshpande S, Bhat D et al. Vitamin B12 status of pregnant Indian

women and cognitive function in their 9-year-old children. Food Nutr Bull

2008;29:249-54.

91. Yajnik CS, Joglekar CV, Lubree HG et al. Adiposity, inflammation and

hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin

Sensitivity in Indian Subjects (CRISIS) Study. Diabetologia 2008;51:39-46.

92. Yajnik CS, Deshpande SS, Jackson AA et al. Vitamin B12 and folate

concentrations during pregnancy and insulin resistance in the offspring: the Pune

Maternal Nutrition Study. Diabetologia 2008;51:29-38.

93. Yajnik CS, Deshmukh US. Maternal nutrition, intrauterine programming and

consequential risks in the offspring. Rev Endocr Metab Disord 2008;9:203-11.

94. Rao S, Kanade A, Joshi S, Yajnik C. Community-specific modifications are

essential for objective assessment of maternal dietary intake - Pune Maternal

Nutrition Study. Public Health Nutr. 2008 Dec 24:1-7. [Epub ahead of print]

95. Krishnaveni GV, Hill JC, Veena SR et al. Low plasma vitamin B12 in pregnancy is

associated with gestational 'diabesity' and later diabetes. Diabetologia

2009;52:2350-8.

96. Chan JC, Malik V, Jia W et al. Diabetes in Asia: epidemiology, risk factors, and

pathophysiology. JAMA 2009;301:2129-40.

Curriculum Vitae

 

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97. Godbole K, Deshmukh U, Yajnik C. Nutrigenetic determinants of neural tube

defects in India. Indian Pediatr 2009;46:467-75.

98. Modi N, Thomas EL, Uthaya SN, Umranikar S, Bell JD, Yajnik C. Whole body

magnetic resonance imaging of healthy newborn infants demonstrates increased

central adiposity in Asian Indians. Pediatr Res 2009;65:584-7.

99. van Steijn L, Karamali NS, Kanhai HH et al. Neonatal anthropometry: thin-fat

phenotype in fourth to fifth generation South Asian neonates in Surinam. Int J

Obes (Lond) 2009;33:1326-9.

100. Bhat DS, Thuse NV, Lubree HG et al. Increases in plasma holotranscobalamin

can be used to assess vitamin B-12 absorption in individuals with low plasma

vitamin B-12. J Nutr 2009;139:2119-23.

101. Rao S, Kanade AN, Joshi SR, Yajnik CS. Community-specific modifications are

essential for objective assessment of maternal dietary intake--Pune Maternal

Nutrition Study. Public Health Nutr 2009;12:1470-6.

102. Rao S, Kanade AN, Yajnik CS, Fall CH. Seasonality in maternal intake and

activity influence offspring's birth size among rural Indian mothers--Pune

Maternal Nutrition Study. Int J Epidemiol 2009;38:1094-103.

103. Yajnik CS. Imperative of preventive measures addressing the life-cycle. Nestle

Nutr Workshop Ser Pediatr Program 2009;63:177-90.

104. Yajnik CS, Janipalli CS, Bhaskar S et al. FTO gene variants are strongly

associated with type 2 diabetes in South Asian Indians. Diabetologia

2009;52:247-52.

105. Yajnik CS. Nutrient-mediated teratogenesis and fuel-mediated teratogenesis:

two pathways of intrauterine programming of diabetes. Int J Gynaecol Obstet

2009;104 Suppl 1:S27-S31.

106. Yajnik PC, Yajnik CS. Predictive equations for body fat in Asian Indians.

Obesity (Silver Spring) 2009;17:935-6.

107. Wijesuriya M, Williams R, Yajnik C. The Kathmandu Declaration: "Life Circle"

approach to prevention and care of diabetes mellitus. Diabetes Res Clin Pract.

([Epub ahead of print]

108. YajnikCS, Deshmukh US. Intrauterine programming of diabetes. Current

medical literature, 2009;26:61-71

Curriculum Vitae

 

22 

 

109. Belsare PV, Watve MG, Ghaskadbi SS, Bhat DS, Yajnik CS, Jog M. Metabolic

syndrome: aggression control mechanisms gone out of control. Med Hypotheses

2010;74:578-89.

110. Chauhan G, Spurgeon CJ, Tabassum R et al. Impact of common variants of

PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1

on the risk of type 2 diabetes in 5,164 Indians. Diabetes 2010;59:2068-74.

111. Chauhan G, Spurgeon CJ, Tabassum R et al. Response to Comment on:

Chauhan et al. (2010) Impact of Common Variants of PPARG, KCNJ11, TCF7L2,

SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2

Diabetes in 5,164 Indians. Diabetes;59:2068-2074. Diabetes 2010;59:e16.

112. Deshmukh US, Joglekar CV, Lubree HG et al. Effect of physiological doses of

oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled,

double-blind trial in India. Eur J Clin Nutr 2010;64:495-502.

113. Katre P, Bhat D, Lubree H et al. Vitamin B12 and folic acid supplementation

and plasma total homocysteine concentrations in pregnant Indian women with

low B12 and high folate status. Asia Pac J Clin Nutr 2010;19:335-43.

114. Kinare AS, Chinchwadkar MC, Natekar AS et al. Patterns of fetal growth in a

rural Indian cohort and comparison with a Western European population: data

from the Pune maternal nutrition study. J Ultrasound Med 2010;29:215-23.

115. Rafnsson SB, Saravanan P, Bhopal RS, Yajnik CS. Is a low blood level of

vitamin B12 a cardiovascular and diabetes risk factor? A systematic review of

cohort studies. Eur J Nutr 2010.

116. Veena SR, Krishnaveni GV, Srinivasan K et al. Higher maternal plasma folate

but not vitamin B-12 concentrations during pregnancy are associated with better

cognitive function scores in 9- to 10- year-old children in South India. J Nutr

2010;140:1014-22.

117. Wills AK, Chinchwadkar MC, Joglekar CV et al. Maternal and paternal height

and BMI and patterns of fetal growth: The Pune Maternal Nutrition Study. Early

Hum Dev 2010.

118. Yajnik CS, Ganpule-Rao AV. The obesity-diabetes association: what is different

in indians? Int J Low Extrem Wounds 2010; 9:113-5.

119. Yajnik CS, Editorial, Fetal programming of diabetes: still so much to learn!

Diabetes Care 2010;33:1146-8.

Curriculum Vitae

 

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120. Ebrahim S, Kinra S, Bowen L, Andersen E, Ben-Shlomo Y, Lyngdoh T,

Ramakrishnan L, Ahuja RC, Joshi P, Das SM, Mohan M, Davey Smith G,

Prabhakaran D, Reddy KS; Indian Migration Study group. The effect of rural-to-

urban migration on obesity and diabetes in India: a cross-sectional study. PLoS

Med. 2010 Apr 27;7(4):e1000268.

121. Shastry S, Simha V, Godbole K, Sbraccia P, Melancon S, Yajnik CS, Novelli G,

Kroiss M, Garg A. A novel syndrome of mandibular hypoplasia, deafness, and

progeroid features associated with lipodystrophy, undescended testes, and male

hypogonadism. J Clin Endocrinol Metab. 2010 Oct;95(10):E192-7. Epub 2010 Jul

122. Ponnusamy Saravanan , Chitranjan S Yajnik, Role of maternal vitamin B12 on

the metabolic health of the offspring: a contributor to the diabetes, British Journal

of Diabetes & Vascular Disease 2010 10: 109.

123. Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen LK

Gokulakrishnan K, Hanefeld M, Ingelsson E, Lai WA, Lin SY, Lind L,

Lohsoonthorn V, Mohan V, Muscari A, Nilsson G, Ohrvik J, Chao Qiang J, Jenny

NS, Tamakoshi K, Temelkova-Kurktschiev T, Wang YY, Yajnik CS, Zoli M, Khaw

KT, Forouhi NG, Wareham NJ, Langenberg C. Differential white blood cell count

and type 2 diabetes:systematic review and meta-analysis of cross-sectional and

prospective studies.PLoS One. 2010 Oct 18;5(10):e13405.