DOCTORATE OF PHARMACOLOGICAL, EXPERIMENTAL AND CLINICAL SCIENCES

I EDITION SPRING CAMP

GARGNANO - Garda Lake APRIL 26-28 – 2017 PALAZZO FELTRINELLI

Program

WEDNESDAY - April 26 2017

Lunch ore 13:00 Oral Session Chairmen: A. Panerai, M.D.,Ph.D. and A. Corsini, Ph.D.

15:00 Ilaria Di Renzo Muscular dystrophy: from current to emerging therapeutic strategies in limb girdle-2d and duchenne muscular dystrophies

16:00 Pier Paolo La Fauci From in silico to in vivo: an integrated computational and imaging pipeline to discriminate endocrine disrupters (EDs) vs endocrine modulators (EMs). State of the art of in vitro evaluation

15:20 Marco Fumagalli Strawberry tannins inhibit IL-8 release in human gastric epithelial cells by different mechanisms

16:20 Federica Lolli From metabolic health to metabolic illness: sex-specific role of hepatic Era

15:40 Hugo F. Carvalho Mutual regolation of receptor subunits expression: a study on CAML/WRB receptor complex

16:45 Coffee Break

WEDNESDAY - April 26 2017

POSTER SESSION Ph.D. Students - Cicle 32°

h 17:30

Margherita Botta Proprotein convertase subtilisin/kexin-type 9

(PCSK9) and metabolic syndrome: in vitro and in vivo evidences

Nicolò Carrano The NMDAR-associated synaptonuclear messenger RNF10 is involved in neurodevelopment

Federica Galimberti Evaluation of drug use appropriateness in elderly: literature search and selection of proper explicit indicators

Saba Khalilpour

Effect of estrogen on microglia polarization

Giorgia Moschetti Prokineticin system: a role in experimental chemotherapy-induced peripheral neuropathy

Maria Serena Paladini Depression vulnerability and resilience: impact of adverse life events

Leonardo Sandrini Depression and CAD comorbidity: potential role of BDNF

Emanuele Spadafora

Validation of levels of surfactant protein type b (sp-b) as a diagnostic and prognostic marker in the progression of heart failure: preliminary results

DINNER h. 20:00

THURSDAY - April 27

Oral Session Chairmen: M. Mazzanti Ph.D. and A. Panerai M.D.,Ph.D.

08:55 Lecture Prof. Michele Mazzanti, University of Milano presented by Prof. A. Panerai Neurodegeneration and Glioblastoma: a common pathophysiological mechanism with distinct fate?

11:20 Coffee Break

10:00

Paola Brivio Chronic stress exposure induced the development of cognitive deficits: involvement of genomic vs non-genomic effect mediated by glucocorticoid receptors

11:40

Ana Ribeiro A spine to nucleus signalling pathway in Alzheimer's disease

10:20

Lorenza Culotta Deciphering the role of SULT4A1 in brain development and Phelan-McDermid Syndrome pathogenesis

12:00

Sebastien Therin Modulation of the synaptic localization and activity of ADAM10 in AD models

10:40

Laura Gritti eEF2K as a target molecule for epilepsy treatment

12:20

Paolo Tornese Ketamine rescues glutamate release, dendrite morphology and BDNF dendritic trafficking in the hippocampus of rats vulnerable to chronic mild stress

11:00

Anna Longatti RhoGAP2 regulates dendritic spine density and AMPARs composition

12:40

Lina Vendermeulen Linking actin-dependent dendritic spine remodelling and ADAM10 activity in Alzheimer’s Disease: The role of CAP2

Lunch 13:15

THURSDAY - APRIL 27

Oral Session

Chairmen: S. Sozzani, Ph.D. and A. Corsini Ph.D.

14:25 Lecture Prof. Silvano Sozzani, University of Brescia, presented by Prof. A. Panerai Dendritic cells in autoimmunity

16:40 Coffee Break

15:30

Giada Amodeo Human adipose stem cells and their secretome revert painful neuropathy, neuroinflammation and peripheral immune activation in streptozotocin-diabetic-mice

17:00

Davide Marangon Mir-125a-3p negatively regulates the maturation of oligodendrocyte precursor cells and is altered in human multiple sclerosis

15:50

Giulia Dell’Omo Inhibition of SIRT1 deacetylase uncouples anti-inflammatory and chemopreventive actions of NSAIDs

17:20 Lara Pizzamiglio Functional effects of the acute blockade of atm kinase activity

16:10

Silvia Ferrara Defective myelination and brain inflammation in a mouse model of polymicrogyria

17:40 Nathalie Sala Sucrose consumption test as a tool to identify resilience/vulnerability towards acute stress

16:20

Natalia Marchetti Long-term consequences of IL-1β over-production on neuronal development

19:30 SOCIAL DINNER

FRIDAY - April 28

Oral session

Chairmen: P. Parini, Ph.D. and A. Corsini Ph.D.

08:55 Prof. Paolo Parini, University of

Stockholm, Karolinska Institute, presented by Prof. A. Corsini New insights in the pathogenesis of atherosclerosis: role of lipids and inflammation

11:20

Alessandro Di Minno Coronary artery disease and Mediterranean Diet

10:00

Valentina Alfieri Alpha-melanocyte-stimulating-hormone modulates smooth muscle cell phenotype

11:40

Silvia Marchianò Investigating the vascular effect of Proprotein Convertase Subtilisin/Kexin type 9: in vitro and in vivo studies

10:20

Gloria Balzarotti Role of PCSK9 (proprotein convertase subtilisin/kexin type 9) beyond LDLR targeting: focus on glucose metabolism

12:00

Chiara Pavanello Role of LCAT in atherosclerosis

10:40

Veronica Begni Mechanisms of vulnerability to stress and pathological implications

12:20

Chiara Ricci PCSK9 induces a pro-inflammatory response in macrophages

11:00 Coffee Break 13:30 Lunch

Departure at 15:15