prostate cancer outcomes by race & treatment site can-lan sun md phd, smita bhatia md mph,...
TRANSCRIPT
![Page 1: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/1.jpg)
Prostate Cancer Outcomes by Race & Treatment Site
Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD,Gail Washington DNS, Karen Nielsen-Menicucci PhD
12/11/2008
![Page 2: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/2.jpg)
2008 Estimated US Cancer Deaths*
ONS=Other nervous system.Source: American Cancer Society, 2008.
Men294,120Lung & bronchus 31%
Prostate 10%
Colon & rectum 8%
Pancreas 6%
Liver & intrahepatic bile duct 4%
Leukemia 4%
Esophagus 4%
Urinary bladder 3%
Non-Hodgkin lymphoma 3%
Kidney & renal pelvis 3%
All other sites 24%
![Page 3: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/3.jpg)
Cancer Death Rates* by Sex, US, 1975-2004
*Age-adjusted to the 2000 US standard population.Source: Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Mortality - All COD, Public-Use With State, Total U.S. (1969-2004), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2007. Underlying mortality data provided by NCHS (www.cdc.gov/nchs).
0
50
100
150
200
250
300
1975 1978 1981 1984 1987 1990 1993 1996 1999 2002
Men
Both Sexes
Rate Per 100,000
Women
![Page 4: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/4.jpg)
Cancer Death Rates* Among Men, US,1930-2004
*Age-adjusted to the 2000 US standard population.Source: US Mortality Data 1960-2004, US Mortality Volumes 1930-1959,National Center for Health Statistics, Centers for Disease Control and Prevention, 2006.
0
20
40
60
80
10019
30
1935
1940
1945
1950
1955
1960
1965
1970
1975
1980
1985
1990
1995
2000
Rate Per 100,000
Prostate
![Page 5: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/5.jpg)
Prostate Cancer Mortality Rates in the US, 1969-2004
![Page 6: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/6.jpg)
6
22.6
18.5
53.3
10.4
17.6
African Americans are twice as likely than Whites to die of prostate cancer.
Note: Data are age adjusted to the 2000 standard population. SOURCE: National Cancer Institute, Surveillence, Epidemiology, and End Results (SEER) Program; National Vital Statistics System--Mortality, NCHS, CDC.
Prostate Cancer Death Rates, 2005Prostate Cancer Death Rates, 2005Per 100,000 population
White, Non-Hispanic
Hispanic
African American, Non-Hispanic
Asian and Pacific Islander
American Indian/Alaska Native
Dea
ths
Dea
ths
![Page 7: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/7.jpg)
Why?
More aggressive tumors
More advanced stage at diagnosis
Health insurance and access to care
Difference in screening-early detection
Differences in receiving optimal treatment
Socioeconomic status
Healthcare provider
![Page 8: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/8.jpg)
Aims
Aim 1: Compare mortality rates between African-Americans and Caucasians with newly diagnosed prostate cancer in Los Angeles County after controlling for age, SES, marital status, stage, grade, insurance, and treatment modality.
Aim 2: Compare the mortality rates for prostate cancer between NCI designated comprehensive cancer centers and other treatment facilities in Los Angeles County.
Aim 3: Compare the mortality rates by race for patients with prostate cancer receiving care within NCI cancer centers
Aim 4: Describe the proportion of African-Americans and Caucasians seeking treatment for newly diagnosed prostate cancer at NCI designated cancer centers and other treatment facilities, and understand the role of socioeconomic and insurance status in accessing care at the NCI-designated cancer centers versus other treatment facilities
![Page 9: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/9.jpg)
Data Sources
Los Angeles Cancer Surveillance Program (CSP) White or African-American Diagnosed with prostate cancer 1998-2003
NCI-designated Cancer Center USC-Norris Cancer Center, UCLA-Jonsson Cancer Center,
City of Hope Cancer Center
Office of State Health Planning Department (OSHPD): Teaching status Bed Size Average length of stay Urban vs. Rural Hospital in-patient racial distribution MSSA: % below poverty, racial distribution
![Page 10: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/10.jpg)
Variables
Outcomes
Overall mortality
Prostate cancer-specific mortality
Time to event (in years from the date of diagnosis to date of death or last known date)
Main Exposure
Race: White vs. African-American
NCI designated Cancer Center vs. other non-NCI
designated treatment facilities
![Page 11: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/11.jpg)
Variables
Adjustment variables: Demographics
• SES, age, marital status
Year of diagnosis: 1998-2003
Insurance Tumor information
• Stage (localized, regional, distant)• Grade (well-differentiated, moderately
differentiated, poor/undifferentiated)
Treatment information• Surgery (no, radical/total prostatectomy) • Radiation (yes, no)• Hormone therapy (yes, no)
![Page 12: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/12.jpg)
Preliminary Results
24,360
22886
21426
19817
19309
19298
18984
18,790
Unknown Grade-1474
Unknown Stage-1460
Unknown surgery-1609
Unknown hormone-508
Unknown radiation-11
Unknown Insurance-314
Unknown SES-194
![Page 13: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/13.jpg)
Comparison: White vs. AA
White
N=14, 579
AA
N=4211
Alive 11856 (81%) 3328 (79%)
Dead 2723 (19%) 883 (21%)*
prostate-specific 543 (4%) 200 (5%)*
other 2180 (15%) 683 (16%)*
*P <0.05
![Page 14: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/14.jpg)
Comparison: White vs. AA
White AA
Age at Dx 68 (16-99) 64 (33-93)*
Stage
Local 12831 (88.0%) 3708 (88.1%)
Regional 1290 (8.9%)) 286 (6.8%)*
Distant 458 (3.1%) 217 (5.1%)*
Grade
Well-differentiated 525 (3.6%) 151 (3.6%)
Moderately differentiated 10932 (75.0%) 3177 (75.4%)
Poor/undifferentiated 3122 (21.4%) 883 (21.0%)
*P<0.05
![Page 15: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/15.jpg)
Comparison: White vs. AA
White AA
Treatment Watchful waiting 2284 (15.7%) 925 (20.0%)*
Surgery only 5419 (37.2%) 1420 (33.7%)*
Hormone only 1759 (12.1%) 561 (13.3%)
Radiation only 2371 (16.2%) 691 (16.4%)
Combination of Surgery /hormone /radiation
2746 (18.8%) 614 (14.6%)*
*P<0.05
![Page 16: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/16.jpg)
Comparison: White vs. AA
White AA
SES 1 (highest) 6499 (44.6%) 568 (13.5%)*
2 3667 (25.1%) 719 (17.1%)*
3 2464 (16.9%) 897 (21.3%)*
4 1383 (9.5%) 1072 (25.4%)*
5 (lowest) 566 (3.9%) 955 (22.7%)*
*P<0.05
![Page 17: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/17.jpg)
Comparison: White vs. AA
White AA
Insurance no 211 (1.5%) 195 (4.6%)*
Insurance NOS 806 (5.5%) 144 (3.4%)*
Managed care, HMO PPO 7977 (54.7%) 2329 (55.3%)
Medicare 2781 (19.1%) 439 (10.4%)*
Military, Veterinarian, PHS 290 (2.0%) 251 (6.0%)*
County funded 2514 (17.2%) 853 (20.3%)*
![Page 18: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/18.jpg)
Specific Aim 1
Compare mortality rates between African-Americans and Caucasians with newly diagnosed prostate cancer in Los Angeles County
![Page 19: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/19.jpg)
Overall and Prostate-specific Mortality:White vs. AA
60%
70%
80%
90%
100%
0 1 2 3 4 5 6 7 8 9 10Years after Diagnosis
Sur
viva
l (%
)
PC WhitePC AAOverall WhiteOverrall AA
Overall Mortality P<0.001
Prostate-specificP=0.002
![Page 20: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/20.jpg)
Specific Aim 2
Compare the mortality rates for prostate cancer between NCI-designated Cancer Centers and other treatment facilities in Los Angeles County
![Page 21: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/21.jpg)
Overall and Prostate-specific Mortality: NCI designated comprehensive cancer centers
vs. other treatment facilities
60%
70%
80%
90%
100%
0 1 2 3 4 5 6 7 8 9 10
Years after Diagnosis
Su
rviv
al (
%)
PC NCIPC Non-NCIOverall NCIOverall non-NCI
Prostate-specificP<0.001
Overall mortality P<0.001
![Page 22: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/22.jpg)
Specific Aim 3
Compare the mortality rates by race for patients with prostate cancer receiving care within NCI-designated Cancer Centers
![Page 23: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/23.jpg)
Overall and Prostate-specific Mortality: by Race among patients treated at NCI Cancer Centers
70%
80%
90%
100%
0 1 2 3 4 5 6 7 8 9 10Years after Diagnosis
Su
rviv
al (
%)
PC NCI AAPC NCI White
overall NCI AAOverall NC Wwhite
Prostate-specific P=0.52
Overall Mortality P=0.17
![Page 24: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/24.jpg)
Multivariate analysis
• Aim 1: Compare mortality rates between African-Americans and Caucasians with newly diagnosed prostate cancer in Los Angeles County after controlling for age, SES, stage, grade, insurance, and treatment modality.
![Page 25: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/25.jpg)
Overall mortality: AA vs. White
0.630.68 0.64 0.66
0.74
0.44
0.59
0
1
Univariate + Age + Race + SES + Grade/Stage + Insurance + Treatment
HR
(9
5%
CI)
![Page 26: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/26.jpg)
Prostate-specific mortality: AA vs. White
1.241.17 1.17 1.13 1.11
1.55
1.32
0
1
Univariate + Age + SES + Grade/Stage + Insurance + Treatment + NCI
HR
(95%
CI)
![Page 27: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/27.jpg)
Multivariate analysis
• Aim 2: Compare mortality rates for prostate cancer between NCI designated comprehensive cancer centers and other treatment facilities in Los Angeles County.
![Page 28: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/28.jpg)
Overall mortality: NCI vs. non-NCI
0.630.68 0.64 0.66
0.74
0.44
0.59
0
1
Univariate + Age + Race + SES + Grade/Stage + Insurance + Treatment
HR
(9
5%
CI)
![Page 29: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/29.jpg)
Prostate-specific mortality: NCI vs. non-NCI
0.640.69
0.59 0.610.69
0.59
0.47
0
1
Univariate + Age + Race + SES + Grade/Stage + Insurance + Treatment
HR
(95%
CI)
![Page 30: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/30.jpg)
Multivariate analysis
Aim 3: Compare mortality rates by race for patients with prostate cancer receiving care within NCI-designated Cancer Centers
Due to the small number of AA receiving care at NCI-designated cancer centers, we were unable to perform this analysis.
![Page 31: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/31.jpg)
Specific Aim 4
Aim 4: Understand the role of sociodemographic factors in accessing care at the NCI-designated treatment centers versus non-NCI centers
![Page 32: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/32.jpg)
Non-NCI NCI OR
Race
White
12933 (88.7%)
1646 (11.3%)
1.00
AA 4063 (96.5%) 148 (3.5%) 0.29 (0.24-0.34)
Utilization of NCI-designated Cancer Center
![Page 33: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/33.jpg)
Utilization of NCI Cancer Centers: AA vs. White
0.38 0.39 0.4 0.40 0.42 0.420.45
0.29
0
1
Univariate + SES + Age + Insurance + Maritalstatus
+Stage/Grade
+ Treatment + Year of dx
HR
(95%
CI)
![Page 34: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/34.jpg)
Utilization of NCI-designated Cancer Center
OR (95% CI)
AA vs. White 0.42 (0.35-0.50)
Age at diagnosis (years) 0.95 (0.94-0.95)
SES =1 highest
SES =2 0.61 (0.53-0.69)
SES =3 0.41 (0.35-0.49)
SES =4 0.37 (0.30-0.46)
SES =5 lowest 0.30 (0.22-0.42)
Insurance: no 1.00
Insurance NOS 2.55 (1.58-4.12)
Managed care HMO PPO 1.05 (0.67-1.66)
Medicare 3.22 (2.01-5.13)
County 0.08 (0.02-0.34)
Military/veteran/ PHS 2.12 (1.32-3.40)
![Page 35: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/35.jpg)
Utilization of NCI-designated Cancer Center
OR (95% CI)
Grade: well-differentiated 1.00
Moderately differentiated 3.11 (1.87-5.18)
Poor/undifferentiated 3.79 (2.25-6.36)
Stage: localized 1.00
Regional 1.29 (1.10-1.51)
Distant 1.12 (0.75-1.65)
Treatment: watchful waiting 1.00
Surgery only 2.65 (2.16-3.25)
Hormone only 0.80 (0.59-1.09)
Radiation only 1.04 (0.81-1.33)
Multiple 1.36 (1.09-1.70)
Year of Dx (more recent years) 1.06 (1.03-1.10)
![Page 36: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/36.jpg)
Conclusion
AA have a higher overall and prostate-specific mortality on univariate analysis
AA have comparable overall and prostate specific mortality to Whites after adjustment for sociodemographic factors, tumor characteristic, treatment modality, and treatment site
NCI-designated cancer centers have lower overall and prostate specific mortality compared to non-NCI treatment facilities
This difference persists after adjustment for all clinical and sociodemographic factors
Within NCI-designated cancer centers, AA have comparable overall and prostate-specific mortality to Whites Within the constraints of the limited sample size
AA are less likely to use NCI-designated Cancer Centers Independent of SES, insurance, and tumor factors
![Page 37: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/37.jpg)
Future Plans (Year 02)
Current data set demonstrates that only 148 AA utilized the 3 NCI-designated Cancer Centers in LAC
Expand the scope of analysis Obtain data from CSP for 1976 to 2003
Explore the reasons of inferior outcomes at non-NCI designated Cancer Centers Data from Office of Statewide Health Planning and
Development.• Secondary quality indicators• Teaching status, bed size, hospital in-patient average stay, MSSA
poverty, racial distribution,
![Page 38: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/38.jpg)
![Page 39: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/39.jpg)
Thank you!
![Page 40: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/40.jpg)
Does Treatment Site really make a difference?
In-hospital short-term mortality after Prostatectomy
High volume of prostectomies associated with low mortality
• Medicare claims data
• n=101,604 between 1991 and 1994
• Nationwide Inpatient Sample
• n=66,693 between 1989-1995
Yao, S.L. and G. Lu-Yao, Population-based study of relationships between hospital volume of prostatectomies, patient outcomes, and length of hospital stay. J Natl Cancer Inst, 1999. 91(22): p. 1950-6.
Ellison, L.M., J.A. Heaney, and J.D. Birkmeyer, The effect of hospital volume on mortality and resource use after radical prostatectomy. J Urol, 2000. 163(3): p. 867-9.
![Page 41: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/41.jpg)
Does NCI designation exert an effect on outcomes ?
National Cancer Act
Establish regional centers of excellence in research and patient care.
To be NCI designated• Excellence in Research• Excellence in Cancer Prevention• Excellence in Clinical Services
![Page 42: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/42.jpg)
NCI-Designation
Medicare database Mortality after cystectomy, colectomy,
pulmonary resections, pancreatic resection, gastrectomy and esophagectomy
NCI Centers had lower operative mortality in 4/6 procedures
Long term mortality: no difference
Birkmeyer, N.J., et al., Do cancer centers designated by the National Cancer Institute have better surgical outcomes? Cancer, 2005. 103(3): p. 435-41.
![Page 43: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/43.jpg)
Overall HR Prostate-specific HR
AA vs. White 1.08 (0.99-1.17) 1.12 (0.93-1.35)
NCI center vs. non-NCI 0.75 (0.64-0.88) 0.69 (0.49-0.97)
Age at diagnosis (years) 1.05 (1.04-1.06) 1.02 (1.01-1.03)
SES =1 highest 1.00 1.00
SES =2 1.21 (1.10-1.33) 1.08 (0.87-1.33)
SES =3 1.33 (1.21-1.47) 1.26 (1.02-1.55)
SES =4 1.37 (1.23-1.52) 1.15 (0.91-1.46)
SES =5 lowest 1.46 (1.29-1.66) 1.29 (0.99-1.68)
No Insurance: 1.00
Insurance NOS 0.53 (0.39-0.71) 0.46 (0.25-0.84)
HMO PPO 0.84 (0.67-1.05) 0.91 (0.60-1.39)
Medicare 0.86 (0.68-1.08) 0.82 (0.53-1.28)
Military/Vet/ Indian/PHS 0.80 (0.61-1.06) 0.70 (0.40-1.22)
County funded 0.82 (0.65-1.03) 0.74 (0.48-1.15)
![Page 44: Prostate Cancer Outcomes by Race & Treatment Site Can-lan Sun MD PhD, Smita Bhatia MD MPH, Lennie Wong PhD, Gail Washington DNS, Karen Nielsen-Menicucci](https://reader036.vdocument.in/reader036/viewer/2022062515/56649f4c5503460f94c6cfa9/html5/thumbnails/44.jpg)
Overall HR Prostate-specific HR
Grade: well-differentiated 1.00 1.00
Moderately differentiated 1.08 (0.91-1.28) 1.68 (0.91-3.07)
Poor/undifferentiated 1.69 (1.42-2.01) 4.87 (2.66-8.92)
Stage: localized 1.00 1.00
Regional 1.25 (1.07-1.38) 2.28 (1.76-2.94)
Distant 3.76 (3.38-4.18) 14.72 (12.21-17.76)
Treatment: watchful waiting 1.00
Surgery only 0.31 (0.28-0.35) 0.19 (0.13-0.27)
Hormone only 1.04 (0.95-1.15) 1.29 (1.05-1.60)
Radiation only 0.61 (0.55-0.68) 0.50 (0.36-0.70)
Multiple 0.67 (0.60-0.74) 0.86 (0.67-1.09)
Year of Dx 1.03 (1.01-1.06) 0.98 (0.93-1.03)