RNF20 protein required for MLL-rearranged leukemia amplification

and Study describes how multiple RNA

binding proteins cooperatively control genetic splicing code.

Nataly Giraldo DuqueMedicine Student 3° semestreU.P.B

AML has symptoms like fatigue, difficulty to coagulate and high-risk infections. Now the medical treatment to patients who suffer this kind of cancer is about chemotherapy and bone-marrow transplant.

This process happens inside cell nucleus, and during transcription processes and translation can happen alterations and it can produce cancer.

RNFE20 protein required for MLL-rearranged leukemia

amplification

Proceedings of the National Academy of Sciences

Published on February 12, 2013

CSHL Cold Spring Harbor Laboratory is a private, non-profit institution with research programs focusing on:• Cancer• Neurobiology• plant genetics

that have studied the molecular cause of AML and its possible solution.

• Childhood Acute Leukemia is caused by the order

alteration of a gene called Mixed-Lineage Leukemia

(MLL).

• The problem lies in proteins of the chromatin, and for

that reason the scientists of Vakoc Laboratory are

looking for new therapeutic targets in this proteins.

This mechanism has been used with other medicines

and probably in the future the LMA treatment will consist

in the effect of the medicine on the RNF20 and the

target proteins like the Ubiquitin.

The expression of the gene that caused LMA depends on the RNF20 protein, for that reason the researchers are using this knowledge to discover therapeutic targets that affect this protein.

OPINIONI think this research work is so much

important, because it provided outstanding advances to develop the

medical care to LMA. Besides, I think the medical cure discovery is coming up

soon and it benefits enormously to the cancer patients, because they would avoid chemotherapy that is highly degenerative method to organism

Study describes how multiple RNA binding proteins

cooperatively control genetic splicing code.

Cell Reports

Published on february 16, 2013

• Some kind of cancer and neurodegenerative upsets can be caused by upsets in the joint process of the RNA.

• Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are proteins groups

• they join the RNA and help to regulate the expression of other proteins through the control in the alternative splicing process of gene.

The aim of the studies is predicting the joint process of

the RNA in different kind of cells and it can be possible

understanding what mechanism do joint proteins use to

regulate the alternative splicing and when scientists

know about it, they will be able to develop medicines to

attack the specific cause of some illnesses.

hnRNP regulate by their self and they also regulate to other RNA binding proteins.

Most of changes that happen in cancer are on introns, and as before it was mentioned, they are eliminated by splicing, although the intronic regions often join with hnRNB proteins.

OPINION

I think this discovery about the link between the hnRNP proteins and the splicing regulation is so much useful to science, because this discovery approximates us treatments to frequent diseases around the world like cancer y neurodegenerative upsets, therefore I think scientists should continue with the research, because it would bring a lot of positive impacts to society.

Medical utility

This study could radically change the prognosis of person who get LMA

• LMA • No LMA

Cromatina

MLL

(ON)

Ubiq

uit

in

a

RNF20

ubiq

uit

ina

drug

cromatina

MLL

OFF

Medical utility

Attack the specific cause of cancer

The study is very important not only for people with cancer, but also for those who suffer from diseases that are caused by introns that were not eliminated.

REFERENCES

• News medical “RNF20 protein required for MLL-rearranged leukemia amplification”

February 12, 2013, Proceedings of the National Academy of Sciences[http://www.news-medical.net/news/20130212/RNF20-protein-required-for-MLL-rearranged-leukemia-amplification.aspx?page=2]

• News Medical “Study describes how multiple RNA binding proteins cooperatively control genetic splicing code”

February 17,2013, Cell Press' new[http://www.news-medical.net/news/20120217/Study-describes-how-multiple-RNA-binding-proteins-cooperatively-control-genetic-splicing-code.aspx]

• Wikipedia “Cold Spring Harbor Laboratory “ February 28, 2013[http://en.wikipedia.org/wiki/Cold_Spring_Harbor_Laboratory]

THANKS