protein(structure( - weber state...
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Protein Structure
Figure 34: Schema4c of x-‐ray crystallography experiment.
Adapted from C. I. Branden and J. Tooze. Introduc)on to Protein Structure, Second edi)on. Garland Science, 1999.
Figure 16AB: Gel electrophoresis.
Adapted from B. E. Tropp. Biochemistry: Concepts and Applica)ons, First edi)on. Brooks/Cole Publishing Company, 1997.
Figure 01: Structure of an α-‐amino acid
Figure 06: Amino acids with nonpolar side chains
Figure 07: Pep4de bond forma4on in the laboratory
Figure 23a: Protein structure.
Adapted from B. E. Tropp. Biochemistry: Concepts and Applica)ons, First edi)on. Brooks/Cole Publishing Company, 1997.
Figure 29: Macroscopic dipole in the α-‐helix
Adapted from R. H. GarreV and C. M. Grisham. Biochemistry, Third edi)on. Brooks/Cole Publishing Company, 2005.
Figure 30B: An4parallel β pleated sheet
Adapted from D. C. Nelson and M. M. Cox. Lehninger Principles of Biochemistry, Fourth edi)on. W. H. Freeman & Company, 2004.
Figure 32ABCD: A) Hairpin turn B) Helix-‐loop-‐helix C) β-‐α-‐β unit D) Greek key
Figure 23bcd: Protein structure.
Adapted from B. E. Tropp. Biochemistry: Concepts and Applica)ons, First edi)on. Brooks/Cole Publishing Company, 1997.
Figure 35B: Crystal structure displayed in s4ck form.
Structures from Protein Data Bank 1JVT. L. Vitagliano, et al., Proteins 46 (2002): 97-‐104. Prepared by B. E. Tropp.
Figure 35C: Crystal structure shown in ribbon form.
Structures from Protein Data Bank 1JVT. L. Vitagliano, et al., Proteins 46 (2002): 97-‐104. Prepared by B. E. Tropp.
Figure 35A: Crystal structure of ribonuclease A displayed in space filled form.
Structures from Protein Data Bank 1JVT. L. Vitagliano, et al., Proteins 46 (2002): 97-‐104. Prepared by B. E. Tropp.
Figure 06: Human deoxyhemoglobin with 2,3-‐bisphosphoglycerate bound to the twoß-‐globin chains.
Structure from Protein Data Bank 1B86. V. Richard, G. G. Dodson, and Y. Mauguen, J. Mol. Biol. 233 (1993): 270-‐274. Prepared by B. E. Tropp.
Figure 12: Reac4on coordinate diagram for an uncatalyzed reac4on (red) and an enzyme catalyzed reac4on (blue).
Figure 14A: Lock-‐and-‐key model of enzyme-‐substrate interac4on
Adapted from C. K. Mathews, et al. Biochemistry: Third edi)on. Pren4ce Hall, 2000.
Figure 14B: Induced fit model
Adapted from C. K. Mathews, et al. Biochemistry: Third edi)on. Pren4ce Hall, 2000.
Figure 16: Hexokinase, an example of induced fit.
Photos courtesy of Thomas A. Steitz, Yale University.