proteoglycans are conjugates of proteins and ...rebecca/153a/w11/lectures/153a...proteoglycans are...
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Proteoglycans are conjugates of
proteins and glycosaminoglycans
Proteoglycans are major components of
connective tissue
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Networks of protein and carbohydrate inter-
actions fix a cell to the extracellular matrix
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Some proteoglycans are components of cell
membranes & influence surface interactions
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Glycoproteins (glycosylated proteins) are
proteins with oligosaccharides attached
N-linked to Asn(attached during synthesis)
O-linked to Ser or Thr(attached after folding)
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Diversity in the sequence of the attached sugar
(microheterogeneity)
and in patterns of attachment to proteins (glycoforms)
Glycosylation adds great diversity to
proteins
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Glycosylations can influence protein
structure
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Glycolipids are usually found on the cell
surface and are important in recognition
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Glycoproteins and glycolipids are
recognized and bound by lectins
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