psychological correlates of chronic pain and...
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Psychological Correlates of Chronic Pain and Treatment Adherence
by
Emma Thompson
Bachelor of Arts (Psychology)(GDip) (Deakin University)
Submitted in partial fulfillment of the requirements for the degree of
Doctor of Psychology (Health)
Deakin University
August 2017
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Acknowledgements
I would like to start by thanking my supervisor, Dr. Jaclyn Broadbent, for the continued
support and encouragement she has provided throughout my time as her student. I have been
lucky to have a supervisor who has been so patient, understanding, and prompt to respond to
questions and review drafts. I would also like to express my gratitude to Prof. Petra Staiger,
Dr. Matthew Fuller-Tyszkiewicz, and Dr. Melanie Bertino for their advice and contribution
to my thesis.
A special thank you to my family who undeniably experienced all of the ups and downs of
my research. Especially my mother, Sharon, for providing a listening ear, a shoulder to cry
on, and encouraging me through every hurdle. Thank you for helping me to redirect my focus
and maintain perspective when I felt lost. My husband, Nathan, thank you for your patience,
optimism, and many motivational pep-talks. And my son, Thomas, thank you for giving me
the strength and determination to cross the finish line. Completing this work would have been
all the more difficult if it were not for their unwavering support.
My friends and colleagues, thank you for providing me a much-needed form of escape from
my studies and for helping to keep me positive through the hard times.
Finally, I would like to thank Deakin University, The Victorian Rehabilitation Centre, and
the participants included in my studies for allowing me the opportunity to undertake this
research.
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Abstract
This thesis explores the role of psychological factors and co-morbid affective disorders
involved in chronic pain outcomes, in particular, treatment adherence. Study One was a
systematic review examining the predictive nature of various pain-related beliefs on
treatment adherence during and after multidisciplinary intervention. The review found ten
eligible papers and highlighted various cognitions as predictors of treatment adherence
outcomes. Pain self-efficacy was found to be the most commonly researched predictor of
treatment adherence. The reviewed literature also showed support for other cognitions such
as fear-avoidance beliefs, perceived disability, catastrophizing, and perceived benefits and
barriers. Based on the findings of the review, further research with more refined and
standardized methodologies is encouraged to better understand the contribution of pain-
related cognitions on adherence behaviour.
In light of this review, Study Two utilized a retrospective design to investigate the role of
pain-related cognitions and their associations with pain and affective disorders using an
innovative analytic technique (network analysis). The participants were 169 chronic pain
patients aged 22-80 years old who had attended a multidisciplinary pain management
program. Participants completed a battery of questionnaires at the beginning of their allocated
program. Network analysis identified pain self-efficacy, fear-avoidance beliefs, and
perceived disability as important constructs in the relationship between chronic pain and
affective disorders, albeit in different ways. That is, whereas, pain self-efficacy was found to
have direct links to other constructs in the network model, fear avoidance and perceived
disability seemed to function more as mediators, linking other constructs in the model.
Perceived control and anxiety were found to be less influential in the model. This study was
exploratory and showed that various pain-related cognitions play a significant role in the
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experience of pain and co-morbid psychopathology. However, due to the limitation of cross
sectional research, replication of these findings using a longitudinal design is needed to
strengthen these results.
As an extension of the systematic review and Study Two, Study Three utilised a longitudinal
prospective design to evaluate how the measurement timing and change in a combination of
pain-related cognitions and psychological factors predict adherence post-treatment.
Participants were 61 chronic pain patients aged 31-72 years old who had completed a
multidisciplinary pain management program between 2014 and 2016. Self-report measures
were collected at pre-program, program discharge, and 3-6 months post-program.
Correlation, moderation and hierarchical regression were used to statistically analyse the
data. Study Three results revealed pain self-efficacy (at both pre- and post-program) to be the
only predictor variable to positively correlate with treatment adherence. Moderation analysis
revealed that change in anxiety was the only variable to moderate the main effects of a
proposed risk factor on treatment adherence. Finally, hierarchical regression showed that
depression and fear-avoidance beliefs (both at post-intervention) were unique positive
predictors of treatment adherence maintenance. Based on these longitudinal findings,
depression and fear-avoidance were shown to be important for post-program adherence to
treatment recommendations. However, larger samples of participants and more objective
measures of treatment adherence are recommended for future research to better clarify the
predictive value of these variables for self-maintenance behaviour following intervention.
Together, these three studies highlight that various specific psychological factors contribute
to the experience of chronic pain and treatment adherence. This research has important
clinical implications, highlighting the importance of psychological factors on chronic pain
outcomes and the need for patients to be more thoroughly screened for at-risk levels of these
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factors pre- and post-intervention. Based on the collective findings of these studies,
psychological interventions based on reducing fear-avoidance, depression and anxiety whilst
also strengthening pain self-efficacy would be helpful to chronic pain patients and may
improve treatment outcomes in Australia.
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Table of Contents
Chapter 1 Introduction .......................................................................................................... 1
1.1 Chronic Pain: An Overview ............................................................................................. 5
1.1.1 Definitions ................................................................................................................. 5
1.1.2 Prevalence .................................................................................................................. 7
1.1.3 Summary .................................................................................................................... 9
1.2.1 Musculoskeletal pain ............................................................................................... 10
1.2.2 Migraine................................................................................................................... 11
1.2.3 Complex Regional Pain Syndrome.......................................................................... 12
1.2.4 Abdominal pain ....................................................................................................... 13
1.2.5 Multiple pain locations ............................................................................................ 13
1.2.6 Pain Intensity and suffering ..................................................................................... 14
1.2.7 Summary .................................................................................................................. 15
1.3 The Biopsychosocial Model ........................................................................................... 16
1.4 Pain-related disability ..................................................................................................... 18
1.5 Intervention and adherence ............................................................................................ 19
1.5.1 Chronic pain management ....................................................................................... 19
1.5.2 Treatment adherence ................................................................................................ 20
1.5.3 Summary .................................................................................................................. 22
1.6 Psychosocial factors influencing chronic pain and treatment adherence ....................... 22
1.6.1 Pain-related cognitions ............................................................................................ 22
1.6.1.1 Pain self-efficacy .............................................................................................. 23
1.6.1.2 Expectation of solicitousness ............................................................................ 25
1.6.1.3 Perceived disability ........................................................................................... 27
1.6.1.4 Catastrophising and fear-avoidance beliefs ...................................................... 28
1.6.1.5 Perceived control and belief in medical cure .................................................... 30
1.6.2 Co-morbid psychopathology ................................................................................... 32
1.6.2.1 Depression and chronic pain ............................................................................. 33
1.6.2.2 Anxiety and chronic pain .................................................................................. 35
1.6.3 Summary .................................................................................................................. 37
1.7 Summary and Rationale ................................................................................................. 38
1.7.1 Study One ................................................................................................................ 38
1.7.2 Study Two................................................................................................................ 39
1.7.3 Study Three.............................................................................................................. 39
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1.8 Conclusion ...................................................................................................................... 40
References ............................................................................................................................ 42
Chapter 2 Study One: Do pain-related beliefs influence treatment adherence? A
systematic review ................................................................................................................... 63
Abstract ................................................................................................................................ 64
2.1 Introduction .................................................................................................................... 65
2.2 Method ........................................................................................................................... 67
2.2.1 Search strategy ......................................................................................................... 67
2.2.2 Eligibility criteria ..................................................................................................... 69
2.2.3 Selection process ..................................................................................................... 69
2.2.4 Data abstraction ....................................................................................................... 69
2.3 Results ............................................................................................................................ 83
2.3.1 Description of included studies ............................................................................... 83
2.3.2 Methodology ............................................................................................................ 84
2.3.3 Outcome measures ................................................................................................... 85
2.3.4 Pain-related beliefs investigated .............................................................................. 86
2.3.4.1 Self-efficacy ...................................................................................................... 86
2.3.4.2 Perceived disability ........................................................................................... 87
2.3.4.3 Catastrophising ................................................................................................. 87
2.3.4.4 Control beliefs ................................................................................................... 88
2.3.4.5 Fear-avoidance beliefs ...................................................................................... 88
2.3.4.6 Other pain-related belief ................................................................................... 89
2.4 Discussion ...................................................................................................................... 89
2.4.1 Which pain-related beliefs have been investigated as correlates of treatment
adherence and what do the findings reveal? ..................................................................... 90
2.4.2 What methodological issues arise in studies of pain-related beliefs and treatment
adherence to date? ............................................................................................................ 92
2.4.3 What recommendations can be made based on research to-date? ........................... 95
2.5 Conclusion ...................................................................................................................... 97
References ............................................................................................................................ 98
Chapter 3 Method .............................................................................................................. 103
3.1 Study Two method expanded ....................................................................................... 103
3.1.1 Participants ............................................................................................................ 103
3.1.2 Materials ................................................................................................................ 104
3.1.3 Measures ................................................................................................................ 105
3.1.3.1 Demographic information ............................................................................... 105
3.1.3.2 Affective symptoms ........................................................................................ 105
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3.1.3.3 Pain self-efficacy ............................................................................................ 106
3.1.3.4 Fear-avoidance beliefs .................................................................................... 106
3.1.3.5 Perceived control ............................................................................................ 107
3.1.3.6 Pain disability.................................................................................................. 108
3.1.4 Procedure ............................................................................................................... 108
3.2 Study Three method expanded ..................................................................................... 109
3.2.1 Participants ............................................................................................................ 109
3.2.2 Treatment ............................................................................................................... 112
3.2.3 Materials ................................................................................................................ 112
3.2.4 Measures ................................................................................................................ 113
3.2.3.1 Depression and Anxiety .................................................................................. 113
3.2.3.2 Pain Self-Efficacy Questionnaire .................................................................... 114
3.2.3.3 The TAMPA Scale of Kinesiophobia ............................................................. 114
3.2.3.4 Survey of Pain Attitudes ................................................................................. 114
3.2.3.4 Treatment Maintenance Questionnaire ........................................................... 114
3.2.4 Procedure ............................................................................................................... 115
References .......................................................................................................................... 117
Chapter 4 Study Two: A network analysis of the links between chronic pain symptoms
and affective disorders ......................................................................................................... 119
Abstract .............................................................................................................................. 120
4.1 Introduction .................................................................................................................. 122
4.1.1 Psychological mechanisms linking affective disorder and pain symptoms .......... 122
4.1.2 A network perspective on psychological influences on affective and pain symptoms
........................................................................................................................................ 124
4.1.3 The present study ................................................................................................... 125
4.2 Method ......................................................................................................................... 126
4.2.1 Participants ............................................................................................................ 126
4.2.2 Measures ................................................................................................................ 126
4.2.2.1 Demographics. ................................................................................................ 126
4.2.2.2 Affective symptoms. ....................................................................................... 126
4.2.2.3 Pain self-efficacy. ........................................................................................... 126
4.2.2.4 Fear-avoidance beliefs. ................................................................................... 127
4.2.2.5 Perceived control. ........................................................................................... 127
4.2.2.6 Pain disability.................................................................................................. 127
4.2.3 Procedure ............................................................................................................... 128
4.2.4 Analytic strategy .................................................................................................... 128
4.3 Results .......................................................................................................................... 129
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4.3.1 Sample characteristics ........................................................................................... 129
4.3.2 Severity of depression and anxiety symptoms ...................................................... 130
4.3.3 Network analyses ................................................................................................... 131
4.4 Discussion .................................................................................................................... 133
4.4.1 Limitations ............................................................................................................. 137
4.4.2 Conclusion ............................................................................................................. 138
References .......................................................................................................................... 139
Chapter 5 Study Three: Post-intervention treatment adherence for chronic pain
patients may depend on psychological factors .................................................................. 148
Abstract .............................................................................................................................. 149
5.1 Introduction .................................................................................................................. 150
5.2 Method ......................................................................................................................... 154
5.2.1 Participants ............................................................................................................ 154
5.2.2 Treatment ............................................................................................................... 154
5.2.3 Measures ................................................................................................................ 155
5.2.3.1 Affective disorder symptoms .......................................................................... 155
5.2.3.2 Pain self-efficacy ............................................................................................ 156
5.2.3.3 Fear-avoidance beliefs .................................................................................... 156
5.2.3.4 Perceived disability ......................................................................................... 157
5.2.3.5 Treatment maintenance ................................................................................... 157
5.2.4 Procedure ............................................................................................................... 158
5.2.5 Data analyses ......................................................................................................... 158
5.3 Results .......................................................................................................................... 160
5.3.1 Adherence to treatment plan for post-intervention ................................................ 161
5.3.2 Paired-samples t-tests ............................................................................................ 162
5.3.3 Hierarchical regression .......................................................................................... 162
5.3.4 Moderation............................................................................................................. 163
5.4 Discussion .................................................................................................................... 165
5.4.1 Limitations ............................................................................................................. 168
5.4.2 Implications and future directions ......................................................................... 169
References .......................................................................................................................... 171
Chapter 6 General Discussion........................................................................................... 176
6.1 Overview of studies conducted .................................................................................... 176
6.1.1 Study One .............................................................................................................. 176
6.1.2 Study Two.............................................................................................................. 178
6.1.3 Study Three............................................................................................................ 179
6.2 Findings for the psychological factors examined ......................................................... 180
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6.2.1 Pain self-efficacy ................................................................................................... 180
6.2.2 Anxiety .................................................................................................................. 182
6.2.3 Depression ............................................................................................................. 183
6.2.4 Fear-avoidance beliefs ........................................................................................... 184
6.2.5 Perceived disability and control ............................................................................ 185
6.3 Novel investigations and findings ................................................................................ 186
6.4 Treatment implications ................................................................................................. 187
6.5 Limitations ................................................................................................................... 190
6.6 Conclusions and future research .................................................................................. 192
References .......................................................................................................................... 195
Appendix A: Deakin University Human Research Ethics Committee ethics approval ..... 201
Appendix B: The Melbourne Clinic Research Ethics Committee ethics approval ............ 202
Appendix C: Participant letter for Study Two ................................................................... 203
Appendix D: Plain Language Statement for Study Two .................................................... 204
Appendix E: Consent form Study Two .............................................................................. 206
Appendix F: Network map without anxiety symptoms for Study Two ............................. 208
Appendix G: Participant letter for Study Three ................................................................. 209
Appendix H: Plain Language Statement for Study Three .................................................. 210
Appendix I: Consent form for Study 3 ............................................................................... 212
Appendix J: Battery of questionnaires for Studies Two and Three ................................... 214
Appendix K: Treatment Maintenance Questionnaire for Study Three .............................. 221
Appendix L: Glossary of definitions .................................................................................. 223
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List of Figures
Figure 1. Loeser’s Model of the Components of Pain .............................................................. 6
Figure 2. Engel’s Biopsychosocial Model of Chronic Pain .................................................... 17
Figure 3. Example of a full search strategy using Medline Complete .................................... 68
Figure 4. Flow diagram of studies included in the review ...................................................... 84
Figure 5. Participant numbers, measures administered by time-point and inclusion and
exclusion criteria for Studies 2 and 3 ..................................................................................... 111
Figure 6. Network map (left-hand side) and associated plot of centrality measures (right-
hand side) for modelled variables .......................................................................................... 132
Figure 7. Graph of the moderating effect of anxiety improvement during treatment for the
relationship between pre-treatment anxiety (AnxietyT1) and level of treatment adherence.
Scores on anxiety at pre-treatment are centered at the mean ................................................. 165
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List of Tables
Table 1. Systematic review table (alphabetical order according to first author)..................... 71
Table 2. List of excluded studies and reasons for exclusion in reverse chronological order .. 80
Table 3. Study three time points and Cronbach’s alpha measures included ......................... 113
Table 4. Means, standard deviations and inter-correlations among pain-related factors
implicated in depression and anxiety ..................................................................................... 131
Table 5. Means, standard deviations and inter-correlations among pain-related factors and
treatment adherence ............................................................................................................... 160
Table 6. Summary of pain-related variables predicting 3-6 month post-intervention treatment
non-adherence ........................................................................................................................ 162
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Chapter 1
Introduction
Chronic pain is a highly prevalent and debilitating health problem, affecting millions
of people around the world (Goldberg & McGee, 2011). The concept of chronic pain is
complex, consisting of a heterogeneous group of pain states with varying degrees of severity,
physiological distribution, and functional impact (McBeth & Jones, 2007). Disability
associated with chronic pain can influence all aspects of a person’s functioning, including
emotional, interpersonal, vocational, as well as physical functioning (Plesh, Adams &
Gansky, 2011). These aspects of functional impairment may be measured in terms of an
individual’s ability to work, level of mobility and independence, emotional distress and
degree of social isolation, among other measures (Plesh et al., 2011). Therefore, successfully
treating pain patients requires attention not only to the biological basis of the symptoms but
also to the range of psychosocial factors that moderate the pain experience and related
disability (Gatchel, Peng, Peters, Fuchs & Turk, 2007). For these reasons, the
biopsychosocial model has become the most widely used theoretical model to understand the
complexity of risk and protective factors associated with chronic pain and related disability
(Kamper et al., 2015; Gatchel, McGeary, McGeary & Lippe, 2014). Early identification of
biopsychosocial factors not only reveals chronic pain patients at risk of poorer outcomes, but
also point to the areas in which such interventions may be employed.
The development of a more holistic approach to chronic pain management has seen
psychosocial factors, including emotions, beliefs, attitudes, and expectations become
increasingly recognised for their impact on chronic pain outcomes. As such, interventions
based on a biopsychosocial model of chronic pain have largely become best practice for
effective chronic pain management (Kamper et al., 2015). For example, Multidisciplinary
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Pain Rehabilitation Programs (MPRPs), have gained considerable momentum in the past
decade. MPRPs aim to reduce distress and disability in patients with chronic pain by
improving functional capacity whilst concomitantly attempting to reduce the impact of
psychosocial factors (Kaiser, Arnold, Pfingsten, Nagel, Lutz & Sabatowski, 2013). Several
studies reflect the success of MPRPs (Fedoroff, Blackwell & Speed, 2014; Oslund et al.,
2009). However, more randomised controlled trials are needed to further establish the
effectiveness of multidisciplinary methods of pain management (Kamper et al., 2015). With
the addition of more evidence-based research, MPRPs provide a promising and
comprehensive treatment approach for chronic pain sufferers.
The role of psychosocial factors (such as cognitive and psychological factors) in
predicting poor outcomes among chronic pain patients is well documented (Jensen, Moore,
Bockow, Ehde & Engel, 2011; Gatchel et al., 2007). Pain-related cognitions that have been
found to impede chronic pain and recovery include low pain self-efficacy (Costa, Maher,
McAuley, Hancock & Smeets, 2011), fear-avoidance beliefs (Crombez, Eccleston, Van
Damme, Vlaeyen & Karoly, 2012), high catastrophising (Richardson et al., 2009),
expectation of solicitousness (Cano, Barterian & Heller, 2008), belief in medical cure
(Nicklas, Dunbar & Wild., 2010), low control beliefs (Baker, Buchanan & Corson, 2008),
and perceived disability (Alschuler, Theisen-Goodvich, Haig & Geisser, 2008).
Psychological disorders such as depression and anxiety are also frequently associated with
poorer treatment outcomes (Gormsen, Rosenberg, Bach & Jensen, 2010). However, unlike
other predictors (e.g., demographic variables) of pain-related disability that have been
considered in previous research, psychosocial factors are amenable to change (Yazdi-Ravandi
et al., 2013). Therefore, research in this area may assist in the development of psychological
and cognitive interventions for chronic pain populations as a whole, as well as targeted
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interventions for chronic pain populations with a higher risk of poor disability and treatment
outcomes.
Various measures of pain-related disability (e.g., return to work, pain intensity) have
received considerable attention throughout the literature over the past decade (Wicksell,
Lekander, Sorjonen & Olsson, 2010; Boonstra, Preuper, Reneman, Posthumus & Stewart,
2008). However, certain treatment-related outcomes, particularly treatment adherence, have
received less focus. There exists ample research examining pain-related outcomes at the
discharge (i.e., completion of a pain management programme) phase of pain management
(Pereira et al., 2014; Kristjánsdóttir et al., 2013). However, exploration of the factors
impacting adherence behaviour post-treatment (i.e., 3months+) remains under investigated.
Adherence to treatment recommendations is important to reduce pain-related disability
(Nicholas et al., 2012). In order to maintain and, in some cases, further improve pain
symptoms following intervention, individuals are required to adopt prescribed self-
management behaviours. However, as illustrated in the broader literature, post-treatment non-
adherence to strategies recommended for effective pain management is not uncommon
(Coppack, Kristensen & Karaheorghis, 2012; Jack McLean, Moffett & Gardiner, 2010).
Consequently, non-adherent individuals are often faced with the re-emergence and, in some
cases, exacerbation of pain symptoms, resulting in pain program re-admissions and
associated healthcare burden (Nicholas et al., 2012). Further research examining what
specific factors predict post-treatment non-adherence are important for preventing relapse and
ongoing disability.
On top of this is the added complexity that the interrelationships between
psychosocial factors may have on post-treatment adherence behaviour (Roditi & Robinson,
2011). There are several unhelpful cognitions and psychological disorders that can interact in
different ways among individuals with chronic pain, potentially worsening pain and disability
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making it more difficult for individuals to maintain self-management strategies (Dobkin et
al., 2010). Research suggests that the more maladaptive cognitions and psychological
disorders that exist among chronic pain patients (and the greater the interactions between
them), the less likely that individuals will successfully adhere to recommended strategies
post-treatment (Kamper et al., 2015). However, past research that has considered the impact
of psychosocial aspects on post-treatment adherence among chronic pain patients has been
narrowly focused; with adherence to pharmacological treatment receiving much of the
literary attention (Nicklas et al., 2010; Manchikanti, Atluri, Trescot & Giordano, 2008). For
these reasons, it is suggested that a more integrated investigation of the multiple influencing
factors and their interactions will enable for further improvements in multidisciplinary
chronic pain intervention and post-treatment outcomes.
This review will discuss the problem of chronic pain, including its prevalence, causes,
and pain locations, as well as the sequelae of unhelpful pain-related cognitions and
psychopathology on treatment adherence outcomes. There will be a specific focus on
psychosocial problems, including pain-related cognitions and co-morbid psychopathology on
chronic pain outcomes, particularly post-treatment adherence. Research that has examined the
role of psychological and cognitive variables in explaining treatment adherence among
chronic pain patients will be discussed. Finally, a research approach is proposed that aims to
investigate the role of multiple factors, including various pain-related cognitions and co-
morbid psychopathology in predicting post-treatment adherence among a sample of
Australian chronic pain patients.
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1.1 Chronic Pain: An Overview
1.1.1 Definitions
Many definitions have been proposed to explain the subjective experience of pain.
The most commonly cited definition, from the International Association for the Study of
Pain, explains pain as “an unpleasant sensory and emotional experience associated with
actual or perceived tissue damage” (Merskey & Bogduk, 1994, pg.1). Pain can be usefully
divided into two subtypes; acute pain and chronic pain (Neville, Peleg, Singer, Sherf &
Shvartzman, 2008). Acute pain begins suddenly and is usually sharp in quality. It is often
experienced after trauma or surgery and produces a normal response to tissue damage. In
most cases, acute pain is short-lived (i.e. days to weeks), and is likely to disappear when the
underlying cause of pain has healed or been treated (Harris, 2011). However, if acute pain
remains unrelieved, progressive and long-lasting (i.e. months or years) chronic pain may
develop. Chronic pain is defined as pain with duration of greater than three months (Loeser &
Treede, 2008) in which continuous and recurrent pain experiences commonly persist beyond
normally expected healing (Neville et al., 2008). In these cases, ‘pain signals’ remain active
in the nervous system for long periods of time causing severe disability. A further distinction
involves nociceptive and neuropathic pain. Nociceptive pain is usually time-limited, meaning
that when the tissue damage heals, the pain typically resolves (with the exception of arthritis;
Loeser & Treede, 2008). Examples of nociceptive pain include sprains, bone fractures and
inflammation obstructions such as arthritis. Neuropathic pain, on the other hand, is caused by
a lesion or dysfunction of the peripheral or central nervous system (e.g., phantom limb pain).
It is generally chronic and disabling, and is among the most challenging to treat (Jensen et al.,
2011).
Despite the general acceptance of the above definitions, they contain several aspects
that complicate the study of the epidemiology of pain (Casey, Greenberg, Nicassio, Harpin &
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Hubbard, 2008). Referring to ‘actual or perceived tissue damage’, excludes the possibility of
a decisive and objective test to clarify the existence of pain. Similarly, ‘unpleasant sensory
and emotional experiences’ emphasise the subjectivity associated with pain. In addition to
these ambiguities are the complications associated with the classification of acute and chronic
pain. Both acute and chronic pain involve a combination of physiological, psychological and
behavioural mechanisms (Gatchel et al., 2014). The complexity of pain is illustrated by
Loeser’s (1982) model of the components of pain (see Figure 1).
Figure 1. Loeser’s Model of the Components of Pain
In this model, the physical origin of pain is considered to be at the core and the pain
experience, suffering, and pain behaviour are considered to be the surrounding layers. These
layers are determined not only by the pain experience, but also by other factors such as
cultural values and reinforcing factors. In line with this model, acute pain has a directive link
between nociception, pain, suffering, and pain behaviour. However, in chronic pain a
directive link with a nociceptive substrate is not always present. That is, chronic pain often
occurs in the absence of tissue damage and develops long after a noxious stimulus has
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stopped exerting an effect (Casey et al. 2008). In the absence of such a link, chronic benign
pain (i.e. also known as idiopathic or somatoform pain) is determined (Neville et al., 2008).
Both idiopathic and somatoform pain are considered psychiatric categories in the third edition
of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III; Fishbain, Goldberg,
Meagher, Steele & Rosomoff, 1986). In the fourth edition (DSM-IV), chronic pain without an
organic explanation is categorised as Chronic Pain Disorder Associated with Psychological
Factors (Hiller, Heuser & Fichter, 2000). With the development of a new edition, the DSM-V
adopts a more biopsychosocial perspective of chronic pain, replacing previous criteria for
Somatic Symptom Disorder (Dimsdale et al., 2013). In line with Loeser’s (1982) multiple
components of pain, new research is aimed at identifying the integrated biological,
psychological, and social causes of and contributors to chronic pain problems.
1.1.2 Prevalence
Population studies have revealed the prevalence of chronic pain to be a worldwide
physical and mental health care problem (Elzahaf, Tashani, Unsworth & Johnson, 2012).
Although there are few estimates of the incidence of global chronic pain, the World Health
Organisation (WHO) has estimated that as many as 1 in 10 adults are newly diagnosed with
chronic pain each year (Goldberg & McGee, 2011). Moreover, a recent review of
epidemiological studies identified chronic pain to occur in 30% (±11.7%) of adults,
worldwide (Elzahaf et al., 2012). Based on the 2012 National Health Interview Survey
(NHIS), 25 million adults in the United States reported chronic pain. Of even greater concern,
Fayaz, Croft, Langford, Donaldson and Jones (2015) found the prevalence of chronic pain in
the United Kingdom to range from 35% to 51.3% (19 population studies, N = 139,933).
Chronic pain is also considered to be a significant healthcare problem within Australia,
however, significantly fewer Australian research data on chronic pain appear to exist
compared to other developed countries such as the US and UK (Azevedo, Pereira, Mendonca,
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Dias & Castro-Lopes, 2012; Schopflocher, Taenzer & Jovey, 2011). Upon review of the
literature, the most recent large Australian population study was conducted nearly two
decades ago (Blyth, March, Brnabic, Jorm, Williamson & Cousins, 2001). At which time,
chronic pain was found to occur in one in five Australians; affecting 17.1% of males and 20%
of females (N = 17,543; Blyth et al., 2001). Another more recent (although, considerably
smaller) study found chronic pain to occur in 19.2% of Australian general practice patients
(N = 1,113; Henderson, Harrison, Britt, Bayram & Miller, 2013). The need for current and
sizeable epidemiological studies identifying the prevalence of chronic pain within Australian
populations is clearly apparent. Based on more recent data, the global pain market has been
valued between $560 and $635 billion annually in health care costs and lost productivity
(Gaskin & Richard, 2012). As these statistics attest, the prevalence and cost of chronic pain is
a major health care problem; one which is expected to increase over the coming years due to
an ageing population (Goldberg & McGee, 2011).
Estimates of gender prevalence have also fuelled a great deal of research on chronic
pain. There is clear consensus throughout the literature that women report chronic pain more
frequently than men (Nahin, 2015; van Hecke, Torrance & Smith, 2013; Johannes, Le, Zhou,
Johnston & Dworkin, 2010), reporting more severe levels of pain (Gatchel et al., 2007), and
pain of longer duration in comparison to men (van Hecke, Torrance & Smith, 2013). These
statistics are similar among children, with female paediatric patients more likely to suffer
chronic pain conditions than males (Goldberg & McGee, 2011). Age is another important
predictor of poor outcome for sufferers of chronic pain. Although variable, research suggests
that the prevalence of chronic pain increases after the age of 50 years. This was shown in
Blyth et al.’s (2001) study which found age prevalence to be highest in the 55-69 year age
group for males and 80-84 year age group for females. However, as previously stated,
Australian populations estimates are outdated and in need of revision. Generally speaking,
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research shows that older adults are often at greater risk of accidental injury and that the
incidence of injury (e.g., osteoarthritic fractures) is likely to increase with age (Deandrea,
Lucenteforte, Bravi, Foschi, La Vecchia & Negri, 2010). Based on an accumulation of
research, older female pain patients and younger male pain patients may be at greater risk of
pain-related disability. In which case, prevention and treatment intervention targeted
specifically at these populations are required.
1.1.3 Summary
Prevalence estimates have highlighted the significance of chronic pain internationally
(Elzahaf et al., 2012) and within Australia (Henderson et al., 2013). Although females have
been shown to experience chronic pain to a greater extent than males (Nahin, 2015), statistics
of age reveal that males and females may be at greater risk of chronic pain at different
lifespan stages (Blyth et al., 2001). Awareness of these population trends have contributed to
an increased concern about chronic pain problems, and suggest that the prevalence of chronic
pain is at significant risk of escalating unless more effective preventative strategies are
employed (Goldberg & McGee, 2011). More population-based data, particularly within
Australia, are needed to more reliably define this burden and the requirements for optimal
health care planning.
1.2 Chronic Pain Localisations
Factors such as the location in the body and distribution of chronic pain may help to
assist in understanding pain-related disability and treatment outcomes (Johannes et al., 2010).
Chronic pain can present in numerous locations of the body, all of which have a combination
of general and unique characteristics. The most common types of chronic pain by location are
musculoskeletal in nature (Dieppe, 2012). Other types of chronic pain include chronic
migraine (Leistad, Nilsen, Stovner, Westgaard, Rø & Sand, 2008), Complex Regional Pain
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Syndrome (CRPS; Bruehl, 2015), and chronic abdominal pain (Kaiser, 2012). Each of these
pain conditions as well as the impact of multiple pain locations and pain intensity will be
discussed in the following sections.
1.2.1 Musculoskeletal pain
Much of the research focus on chronic pain problems has related to musculoskeletal
pain and the burden it produces (Gore, Sadosky, Stacey, Tai & Leslie, 2012; Juniper, Le &
Mladsi, 2009). Musculoskeletal conditions are the most common cause of pain in many
countries. In Australia, there are an estimated 6.1 million (26.9%) cases of chronic
musculoskeletal pain conditions (Arthritis and Osteoporosis Victoria, 2013). Musculoskeletal
pain conditions are different in terms of pathophysiology but linked anatomically and by their
association with pain and impaired physical function (Dieppe, 2012). They include
inflammatory diseases such as rheumatoid arthritis, osteoporosis, and osteoarthritis as well as
conditions of uncertain aetiology such as fibromyalgia (i.e., diffuse and widespread pain;
Ablin, Buskila, Van Houdenhove, Luyten Atzeni, & Sarzi-Puttini, 2012). A large proportion
of the literature also considers musculoskeletal pain conditions to be commonly related to
conditions of traumatic injury (Harris, Young, Rae, Jalaludin & Solomon, 2007). These
include traumatic injuries such as fractures, sprains, strains, dislocations, or lacerations (e.g.,
whiplash injury). And cumulative trauma disorders such as repetitive motion injuries or
disorders associated with repeated trauma (e.g., Carpal Tunnel Syndrome; Dieppe, 2012).
One chronic musculoskeletal pain condition that has received considerable research regarding
its association with traumatic injury is chronic low back pain (CLBP; Juniper et al., 2009;
Cohen, Argoff & Carragee, 2008). The Global Burden of Disease (Vos et al., 2012) study
identified CLBP to be more prevalent than any other condition, including major depression,
diabetes and heart disease. According to previous studies comparing the frequency of
musculoskeletal impairment in the USA, CLBP was found to be the most frequently reported
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pain as a result of occupational injury (Franklin, Rahman, Turner, Daniell & Fulton-Kehoe,
2009). These results suggest considerable pain severity and impairment to be associated with
CLBP, and that those with worse CLBP associated function are less likely to adhere to
treatment; making this population at higher risk of poor outcome.
1.2.2 Migraine
Persistent migraine is another common cause of chronic pain (Leistad et al., 2008),
however prevalence estimates vary considerably. The most recent population-based study
(N=257,339) found chronic migraine prevalence to range between .48% to 1.29% among
adults, with middle aged women most affected (Buse et al., 2012). It is typically characterised
by recurrent and extended periods of pulsating pain that occurs for 15 days or more per
month (Natoli et al., 2009). Chronic migraines are commonly experienced among disabled
workers and victims of traumatic brain injury (Elbers, Hulst, Cuijpers, Akkermans, &
Bruinvels, 2012). Chronic migraines often occur in conjunction with or lead to the
development of other chronic conditions such as musculoskeletal pain (Buse et al., 2012).
However, the direction of the relationship between migraine and other chronic conditions is
unclear and is likely to vary according to severity of pain. In these cases, chronic migraine
may be a risk factor for the development of other chronic pain conditions (Lipton, 2009).
Perhaps chronic migraine sufferers exhibit more psychosocial features (e.g., depression,
catastrophising), exacerbating migraine symptoms and thereby, increasing the risk of
developing other chronic pain conditions. Mental stress has been related to the development
and maintenance of chronic migraine (Pompili et al., 2010; Leistad et al., 2008). For
example, repeated inability to recover from stress may create a vicious cycle resulting in
chronic pain. These various contributing factors can make chronic migraine difficult to
manage and treat. Thus, identifying and managing environmental stressors and psychosocial
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features that may contribute to symptoms of chronic migraine appear to be important
treatment considerations.
1.2.3 Complex Regional Pain Syndrome
Another common chronic pain condition is Complex Regional Pain Syndrome
(CRPS; Bruehl, 2015). Research suggests that it is most commonly encountered following
trauma (i.e., surgery, combat) to a limb and is maintained by abnormalities in the nervous
system (Demir, Özaras, Karamehmetoğlu, Karacan & Aytekin, 2010). Depending on the
specific features, location, and nature of the pain, CRPS may be defined as one of two
categories, CRPS I and CRPS II (Bruehl, 2015). CRPS I is characterised by spontaneous or
evoked pain that is out of proportion to the injury and usually affects the entire distal
extremity. Pain of this type has no discernible nerve damage present and is often not limited
to the distribution of any particular nerve. This may cause a delay in proper diagnosis and
treatment which is likely to have a negative effect on patient outcome. In contrast, CRPS II is
characterised by severe and unbearably intense pain that occurs in the distribution of the
injured nerves (Bruehl, 2015). Most cases follow nerve or tissue injury that result from
fractures, infarctions (i.e., shoulder-hand syndromes), and strokes, with the upper extremity
more often involved than the lower extremity (Demir et al., 2010). Whilst the aetiology of
CRPS is largely misunderstood, there is consensus that psychological factors play some role
in symptomatology. Whereas, some authors suggest that psychological factors play a role in
the course of CRPS rather than its development (Lohnberg & Altmaier, 2013), others claim
that the long-lasting symptoms of CRPS result in psychological changes for patients over
time (Harden et al., 2010). More recent research (Bean, Johnson, Heiss-Dunlop, Lee & Kydd,
2015) examining the psychological factors involved in the development and course of CRPS
is helping to uncover more effective treatment pathways and, thus, improve CRPS-related
outcomes.
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1.2.4 Abdominal pain
Chronic abdominal pain has been studied less than other localisations of pain;
nevertheless, it is a common chronic pain problem. Abdominal pain is thought to occur in 25
percent of adults, with women significantly more likely to report chronic abdominal pain than
men (Tolba, Shroll, Kanu & Rizk, 2015). Similar to other pain localisations, the cause and
pathogenesis of chronic abdominal pain is undoubtedly multifactorial. That is, interactions of
organic, psychological and psychosocial factors are considered essential in the development
of chronic abdominal pain (Berger, Gieteling & Benninga, 2007). There is a wide range of
variation in biological markers potentially responsible for the onset of this particular pain
problem (e.g., inflammatory bowel disease, irritable bowel syndrome, appendicitis).
However, individuals with abdominal pain commonly present with an unknown underlying
cause for their pain and, therefore, are classified as having functional abdominal pain (FAP;
Stinson & Bruce, 2009). By exclusion of an organic aetiology, chronic pain cases are often
assumed to be somatoform (i.e., psychological) in nature (Sperber & Drossman, 2011).
Psychological risk factors shown to predict FAP include fatigue, psychological distress,
health anxiety and illness behaviour (Koloski, Jones, Kalantar, Weltman, Zaguirre & Talley,
2012). The rate of work absenteeism and healthcare visits are also found to be increased
among FAP patients (Sperber & Drossman, 2011). Further exploration of the psychosocial
predictors of chronic abdominal pain may be useful to enhance aetiological understanding
and important areas for targeted intervention.
1.2.5 Multiple pain locations
An additional predictor of poor outcome involves chronic pain that occurs at multiple
sites (Carnes et al., 2007). The results of a recent cross-sectional population-based study
found multi-site pain (pain in >1 region, 33.3% of N=2,953) to be associated with reductions
in work ability and health-related quality of life (Rathleff, Roos, Olesen & Rasmussen, 2013).
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Interestingly, most available population-based studies have focused on a single anatomical
site, with little research highlighting the effects of multiple pain locations. However, as many
authors have observed, localised chronic pain is less common than multi-site (Solidaki et al.,
2010; Carnes et al., 2007) or widespread chronic pain (i.e., fibromyalgia; Kindler, Jones,
Perrin & Bennett, 2010). And by focusing on single site pain, a distorted image of the
distribution and nature of chronic pain may result. Consequently, pain patients may be
mismanaged, funds and other resources may be allocated inappropriately, and other important
factors that predict a poor overall patient outcome may be disregarded (Kamaleri, Natvig,
Ihlebaek & Bruusgaard, 2008). According to these findings, pain problems should not be
considered in isolation, instead, a whole-patient approach should be targeted. For these
reasons healthcare intervention now place an emphasis on multiple-site pain and current
research has developed a focus toward poor outcome predictors associated with multiple pain
locations (Turk, Wilson & Cahana, 2011; Graven-Nielsen & Arendt-Nielsen, 2010).
1.2.6 Pain Intensity and suffering
In addition to assessing for multiple locations of pain, current conceptualisations of
chronic pain management also argue the importance of assessing subjective pain intensity
among patients (Dworkin et al., 2009). Despite its variability (potentially changing from one
moment to the next), pain intensity is the most frequently used measure of chronic pain in
both clinical work and treatment outcome research. The predictive value of pain intensity or
interference has been reported in previous literature (Hjermstad et al., 2011). However, more
recent research appears to be governing a shift from the use of pain intensity as an outcome
measure, instead, focusing on reductions in the overall (i.e., biopsychosocial) suffering of
chronic pain (Ballantyne & Sullivan, 2015; Fishbain, Lewis & Gao, 2015). This is based on
the premise that the suffering associated with chronic pain may be related as much, if not
more, to the meaning attributed to pain as to the level of pain intensity (Lamé, Peters,
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Vlaeyen, Kleef & Patijn, 2005). For example, whereas, acute pain may be associated with
less suffering if one perceives the pain to be finite and necessary to achieve some goal (e.g.,
healing from surgery, delivering a baby), persistent pain may involve more suffering and
greater pain levels if one perceives their condition as hopeless and/or helpless (Ballantyne &
Sullivan, 2015). For this reason, current multidisciplinary intervention aims to primarily
reduce pain suffering and secondarily reduce pain intensity by acknowledging the several
factors (e.g., multiple locations of pain, co-morbid psychopathology, maladaptive cognitions
and other environmental factors) shown to consequently influence the chronic pain
experience (Fedoroff, Blackwell & Speed, 2014; Parr et al., 2012). Despite these advances, it
is important not to disregard the need for pain intensity ratings and their ability to help
clinicians to better understand individual experiences of pain. Identifying patients at risk of
potentially higher levels of pain intensity is important for several reasons. Firstly,
understanding a patient’s perceived level of pain at any point in time may assist clinicians in
choosing appropriate treatments. Secondly, pain intensity reported at different stages of
treatment (i.e., pre-post treatment) may help to elucidate whether any improvements in
chronic pain have been made over time (Hjemstad et al., 2011). For these reasons, obtaining
self-report measures of pain intensity in addition to measuring biopsychosocial factors and
their impact on pain suffering appears to reflect both clinical and theoretical relevance.
1.2.7 Summary
Several chronic pain conditions are found to occur, the most common presentation
shown to be musculoskeletal in nature (Gore et al., 2012). The incidence and complexity of
these chronic pain conditions is likely due to a combination of biological, psychological and
social demands (Shaw, Main & Johnston, 2011). Identification of the biopsychosocial
features that may be contributing to the suffering and intensity of chronic pain are, therefore,
important treatment considerations.
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1.3 The Biopsychosocial Model
Chronic pain is likely to be influenced by multiple factors. To fully understand an
individual’s pain experience, the interrelationships between these factors need to be
considered (Gatchel et al., 2007). Previously, the biomedical model of pain was adopted;
however, this approach offered merely sensory explanations for all pain experiences.
Through the development of research, a one-dimensional perspective used to address the
complexity of chronic pain problems was found to be inadequate (Innes, 2005). More recent
research has led to a greater understanding that treatment of people with chronic pain requires
attention not only to the biological basis of the symptoms, but also to the range of
psychosocial factors that modulate nociception and moderate pain and disability (Kamper et
al., 2015). With an integrated perspective of chronic pain, the biopsychosocial model
incorporates biological (i.e. physical aspects of pain), psychological (i.e. mental, emotional,
and behavioural aspects of pain), and social (i.e. social interactions, environmental context,
and cultural background) factors associated with the pain experience (Gatchel et al., 2007).
Consequently, the biopsychosocial model has become the most widely accepted heuristic
perspective used to understand and treat chronic pain problems (Driscoll & Kerns, 2016;
Gatchel et al., 2014). Figure 2 shows Engel’s (1980) Biopsychosocial Model of Chronic Pain
which illustrates how the biological, psychological and social interactions are involved in the
chronic pain experience.
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Figure 2. Engel’s Biopsychosocial Model of Chronic Pain
According to this model, it is important that the interrelationships between these
factors be viewed in collaboration of one another and simultaneously addressed when treating
chronic pain problems (Driscoll & Kerns, 2016). For example, there is often a distinct
interrelationship between psychological and social factors (i.e. psychosocial factors) which
include elements of both emotion and cognition. In these cases, emotions are considered to be
the more immediate reactions to nociception. Cognitions then attach meaning to the
emotional experience, subsequently triggering additional emotional reactions and thus,
amplifying the experience of pain (Meziat Filho, 2016; Turk, Fillingim, Ohrbach & Patel,
2016). Therefore, psychosocial factors are thought to have the greatest influence on the
development and duration of chronic pain symptoms and associated disability (Turk et al.,
2016). Insight into the effects of psychosocial interrelationships may help to prevent or more
appropriately manage vicious pain cycles (i.e., recurrent nociception, pain, distress) and the
disability that ensues.
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1.4 Pain-related disability
Chronic pain results in varying forms and degrees of functional disability (Verkerk et
al., 2013). Functional disability is highly subjective and may present as impairment in
multiple ways; physically (e.g., muscle tension, limited mobility, insomnia), psychologically
(e.g., depression, anxiety, fear of re-injury), and socio-economically (e.g., work absenteeism,
social isolation, reduced independence; Plesh et al., 2011). As such, pain-related disability
can present very differently, with individuals not appearing disabled in all circumstances. To
illustrate the varying nature of functional disability associated with chronic pain, consider the
following examples. One individual may be unable to tolerate specific jobs with high stress
levels due to the psychological disability associated with their chronic pain condition,
however, may present with minimal physical limitation. Another individual may experience
difficulty in performing specific or prolonged repetitive activities as a result of physical pain-
related disability, however, copes with pain well psychologically. Furthermore, it is not
uncommon for pain sufferers to present with multiple facets of disability (e.g., limited
mobility, depression, work absenteeism), the complexity of these facets likely to increase the
longer in duration pain problems remain poorly managed (Verkerk et al., 2013). Björnsdóttir,
Jónsson and Valdimarsdóttir (2013) found chronic pain respondents (n=1292) had reduced
mobility in the form of being unable to lift or carry groceries (53%), bend, stoop, or kneel
(57.3%), or climb several flights of stairs (62.9%), compared to their pain-free counterparts.
Psychosocial variations of functional disability are also common and can involve challenges
for pain sufferers in maintaining social relationships, for example. As these findings attest,
the potential widespread and multifactorial impact of chronic pain is considerable. Therefore,
it is important to consider the functional implications of chronic pain problems at an
individual level and target intervention accordingly.
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1.5 Intervention and adherence
1.5.1 Chronic pain management
Given the profound consequences that can stem from serious chronic pain problems,
the primary goal of healthcare is to enable sufferers to maximise functional ability and
improve quality of life (Verkerk et al., 2013). To achieve this, chronic pain management
incorporates a multimodal (i.e., physiotherapy, psychology, occupational therapy) method of
rehabilitation which incorporates a combination of self, primary and specialty care (Stanos,
2012). Self-management enhancing interventions that focus on the biopsychosocial predictors
of functional disability have been found to improve outcomes in patients with chronic pain
(Ghadyani, Tavafian, Kazemnejad & Wagner, 2017; Koele, Volker, van Vree, van Grestel,
Köke & Vliet Vlieland, 2014). That is, the foundation for multidisciplinary pain rehabilitation
programs (MPRPs) stem from a biopsychosocial perspective and aim to reduce disability and
distress through cognitive-behavioural intervention (Linton & Shaw, 2011). Although
MPRPs do not aim to ‘cure’ chronic pain conditions, they intend to achieve reduced pain-
related disability that allow the individual to return to their normal activities. These programs,
therefore, hypothesise that changes in cognitive and psychological factors mediate reductions
in functional disability (Koele et al., 2014). This is achieved by including multiple
components of various therapies to address all aspects of chronic pain. In other words, the
provision of physical, psychological, behavioural, and educational interventions are
combined in an attempt to offset the barriers associated with delayed recovery and ongoing
chronic pain problems (Nicholas et al., 2011).
Research has shown MPRPs to have led to substantial improvement in important
socio-economic outcome measures (e.g. return-to-work) in people with chronic pain
problems (Verkerk et al., 2015). Heiskanen, Roine and Kalso (2012) also found significant
improvements in health-related quality of life among chronic pain patients treated at a
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multidisciplinary pain clinic. Moreover, a recent Cochrane systematic review and meta-
analysis (Kamper et al., 2015) found multidisciplinary biopsychosocial rehabilitation to be
more effective than individual treatments in reducing pain-related disability among CLBP
sufferers (N=6,858). Of the 41 randomised controlled trials included in the review, 16 trials
provided moderate quality evidence in support of multidisciplinary intervention for reducing
pain and associated disability. Overall, the literature strengthens the case for multidisciplinary
intervention, providing substantial evidence for the long-term effectiveness of this treatment
approach for effective chronic pain management (Kamper et al., 2015; Steiner et al., 2013;
Oslund et al., 2009).
1.5.2 Treatment adherence
Despite the known benefits of a more comprehensive approach for chronic pain
management, the effectiveness of multidisciplinary intervention is dependent on individuals
successfully adhering to their prescribed treatment regimens. The World Health Organisation
(2003, pg. 3) defines adherence as ‘the extent to which a person’s behaviour (i.e., taking
medication, following a diet or exercise plan, and/or executing lifestyle change), corresponds
with recommendations from a health care professional (HCP)’. Following this definition,
measurement of adherence varies depending on the nature of the treatment recommended by
the HCP (e.g., attendance to supervised sessions and/or assessment of unsupervised home-
based activities; Nicholas et al., 2012). Adherence to treatment recommendations is essential
to reduce disability outcomes associated with chronic pain such as restricted mobility,
reduced working capacity and co-morbid psycho-pathology (Dobkin et al., 2010).
Particularly important is what happens after treatment. Unfortunately, treatment
recommendations are not always adhered to after the completion of an intervention, and
patients may experience exacerbated pain symptoms as a result (Kamper et al., 2015).
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Poor adherence to post-treatment recommendations is a complex problem, especially
for chronic pain affected individuals who, in response to persistent pain, are often faced with
various complex physical and psychological challenges (Dobkin et al., 2010). It is clear that
achieving and maintaining adherence to prescribed multidisciplinary regimens is important;
however, various barriers to adherence appear to exist, thus, compromising the benefit of pain
management (Palazzo et al., 2016). The results of a systematic review conducted by Jack et
al. (2010) identified several factors such as low self-efficacy (6 trials, N=1,296), depression
(4 trials, N=1,367), anxiety (2 trials, N=159), and poor social support (6 trials, N=2,286) as
barriers to poor post-treatment adherence among people with chronic pain. Many other
studies highlight the importance of patient characteristics including unhelpful cognitive and
psychological factors as predictors of treatment non-adherence (Thompson, Broadbent,
Bertino & Staiger, 2016). Chronic pain intensity (Stern, Sánchez-Magro & Rull, 2011),
characteristics of the treatment regimen, and the relationship between healthcare provider and
patient (Escolar-Reina et al., 2010) among various other factors (Cheatle, Comer, Wunsch,
Skoufalos & Reddy, 2014; Zuccaro et al., 2012), have also been examined in the literature for
their predictive value on treatment adherence.
The impact of poor post-treatment adherence is extensive; not only impairing
patient’s quality of life but also contributing to the growing prevalence and economic burden
of chronic pain problems on the public health system (Palazzo et al., 2016). Therefore,
additional research aimed at further understanding what factors contribute to treatment non-
adherence among chronic pain patients is crucial. Improved knowledge in this area will
enable for the development of more effective adherence-enhancing interventions, ideally
resulting in less re-admissions into rehabilitative pain programmes. Not surprisingly, the
majority of previous research on this topic to date focuses on adherence to pain medication
alone (Zuccaro et al., 2012; Nicklas et al., 2010; Manchikanti et al., 2008); however, a shift in
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the conceptualisation and treatment of chronic pain as biological to biopsychosocial calls for
broader examination of factors affecting treatment outcomes. For these reasons, examination
of adherence in response to multidisciplinary intervention is gaining momentum in current
literature (Thompson et al., 2016). Research aimed at further understanding the modifiable
psychosocial factors known to contribute to poor post-treatment adherence is essential to
bolster long-term self-management and improve overall functioning for chronic pain patients.
Not covered in this thesis, however, also an area for future research, involves further
investigation of other modifiable clinician factors (e.g., communication, level of education)
residing in the client that are shown to predict treatment outcome.
1.5.3 Summary
Several aspects of individuals’ physical, emotional, familial, and social functioning
are often affected by chronic pain. Consequently, MPRPs have proliferated and the
integration of cognitive and psychological, as well as biological factors are seen as important
measures of outcome in the treatment of chronic pain problems (Verkerk et al., 2015; Linton
& Shaw, 2011). Despite their effectiveness, problems relating to post-treatment adherence
remain. Several predictors of poor post-treatment adherence have been highlighted (e.g.
Thompson et al., 2016); however, research aimed at better understanding the modifiable
psychosocial factors affecting adherence to pain management is important to maximise
treatment gains and prevent pain-related disability.
1.6 Psychosocial factors influencing chronic pain and treatment adherence
1.6.1 Pain-related cognitions
As shown, the biopsychosocial model hypothesises an important role for psychosocial
responses in the adjustment to chronic pain (Gatchel et al., 2007). Included in these
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psychosocial responses may be a number of beliefs that a patient holds regarding their
condition, potentially impacting their adjustment and functional ability in various ways
(Jensen et al., 2011). Ideally, these cognitive processes help to provide a framework for
interpreting incoming pain signals in a healthy and adaptive way. However, in response to
stress, it is common for patients to demonstrate cognitive patterns that skew their perception
of pain, affecting their ability to cope (Järemo, Arman, Gerdle, Larsson & Gottberg, 2017).
Independent of medical diagnosis, pain location, or severity of pain, personal evaluations of
pain and one’s ability to cope with pain are pivotal in determining disability and treatment
outcomes (Menezes Costa et al., 2011). Unhelpful psychosocial factors may also present a
problem for treatment adherence; hindering patients’ ability to perform and maintain
recommended treatment strategies (Kamper et al., 2015). As a result, individuals with
maladaptive cognitions and coping may be at greater risk of non-adherence related
consequences such as ongoing impaired functioning. However, given that pain-related
cognitions are potentially modifiable (Yazdi-Ravandi et al., 2013), approaches that focus on
improving them may hold promise for reducing adverse outcomes among chronic pain
populations.
1.6.1.1 Pain self-efficacy
Based on the theory of social learning, self-efficacy describes the confidence an
individual has in his or her own ability to achieve a desired outcome (Bandura, 1977).
According to this theory, such beliefs significantly influence the initiation and persistence of
behaviour. In this way, self-efficacy beliefs may help to determine an individual’s adjustment
to chronic pain. In particular, efficacy expectations with regard to pain control, pain coping,
and daily functioning may help to determine one's ability to self-manage pain (Menezes
Costa et al., 2011). Low pain self-efficacy is characterised by a feeling that pain is
uncontrollable and unmanageable, given the physical demands of daily life (Linton & Shaw,
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2011). On the other hand, higher levels of pain self-efficacy have been found to be associated
with lower levels of pain and disability in patients with chronic pain (Menezes Costa et al.,
2011). Furthermore, individuals with strong pain self-efficacy beliefs may be better capable
of persisting at efforts to manage pain using a variety of pain coping strategies. This is
illustrated in Jackson, Wang, Wang and Fan’s (2014) study examining the relationships
between pain self-efficacy beliefs and the outcome of behavioural pain treatment programs.
They found that patients with higher levels of pain self-efficacy reported less intense pain,
less daily interference due to pain, greater perceived life control, less emotional distress, and
higher activity levels than patients with lower levels of pain self-efficacy. Based on these and
other similar findings (e.g. Skidmore, Koenig, Dyson, Kupper, Garner & Keller, 2015),
patients who believe that they can cope with and control pain symptoms are shown to be less
likely to develop feelings of depression, experience less severe pain and fewer activity
limitations.
Self-efficacy is also likely to have implications for how other pain-related beliefs are
interpreted. That is, by improving pain self-efficacy, the reliance on medication and
assistance from other people may be reduced, there may be improvements in the individual’s
perception of pain and disability (Keedy, Keffala, Altmaier & Chen, 2014), and individual’s
may be less likely to engage in catastrophising and fear-avoidance beliefs (Menezes Costa et
al., 2011). The presence of such relationships are based on the findings from a number of
correlational studies that have shown that pain self-efficacy levels are statistically significant
predictors of functioning (Schulz et al., 2015; Rooij et al., 2011). For example, Menezes
Costa et al. (2011) found pain self-efficacy to be a significant predictor of fear-avoidance
beliefs, whereby, high pain self-efficacy levels significantly reduced the likelihood that
patients would engage in fear-avoidance beliefs and behaviours. The overlap between pain
self-efficacy and other cognitive factors is encouraging and supports the importance of self-
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efficacy, either directly or indirectly (e.g., via improved education and understanding of the
biopsychosocial contributors), on chronic pain.
The effects of pain self-efficacy on treatment adherence are also well documented
(Coppack et al., 2012; Nicholas et al., 2012; Dobkin et al., 2010). In a systematic review
conducted by Jack et al. (2010), low self-efficacy was found to be a significant barrier to
treatment adherence (6 trials, N=1,296). Similarly, Krein, Heisler, Piette, Butchart and Kerr
(2007) found self-efficacy to play an important intervening role among older patients’ ability
to self-manage chronic pain. That is, higher self-efficacy was found to reduce the association
between chronic pain and reported difficulty performing pain management techniques. It
makes sense that poor self-confidence may limit an individual’s ability to overcome obstacles
required to initiate and maintain pain management strategies. Therefore, treatment of chronic
pain that focuses on enhancing pain self-efficacy beliefs is important to improve confidence
in one’s ability to continue to perform the necessary prescribed strategies for pain
management, post-treatment. However, to the author’s knowledge, the effectiveness of
changing various pain-related cognitions, including pain self-efficacy, during treatment, as
well as the impact of the interactions between pain-related cognitions on post-treatment
adherence specifically have not been explored.
1.6.1.2 Expectation of solicitousness
In addition to maladaptive beliefs concerning medical cure, patients may also
manifest unhelpful beliefs that other people are responsible for assisting them when they are
in pain (Mohammadi, Dehghani, Sanderman & Hagdoorn, 2017). Patients believing this may
seek assistance and obtain reinforcement for pain behaviours, thereby, limiting their
opportunities to acquire and practice behaviours incompatible with pain (Molton, Stoelb,
Jensen, Ehde, Raichle & Cardenas, 2009). Known as solicitous responding (i.e., offering
sympathy and assistance, or taking over a task in response to a patient’s pain behaviours),
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these beliefs have been linked to greater pain intensity and interference, increased pain
behaviours, depression, and disability (McWilliams, Edmonton, Higgins, Dick & Verrier,
2014). Although social relationships and support play important roles in the experience and
expression of pain-related disability, not all types of support are beneficial. Solicitous
responses from others, while well-intentioned, tend to reinforce pain and disability
behaviours in patients and may unintentionally impede their progress. This is illustrated by
Jensen, Turner, and Romano (2007) study who found an association between solicitous
responses to patient pain behaviours and patient dysfunction. By asking significant others for
more assistance and receiving solicitous responses from family and friends following
treatment, patients were more likely to experience worsening disability over time. On the
other hand, responses provided unconditionally (i.e., not contingent on pain behaviour) were
more likely to result in adaptive patient behaviours, not pain or disability focused.
Increased solicitousness from others is a likely contributing factor to treatment non-
adherence. That is, if others continue to aid in achieving certain activities of daily living (e.g.,
household chores, shopping), patients may not realise the need or importance to perform
these activities for themselves, and thus, pain management strategies aimed at improving
disability and function may not be prioritised (Mohammadi et al., 2017). This is shown
among paediatric chronic pain patients, whereby, solicitous parenting behaviours were found
to be associated with a greater likelihood of poor treatment participation and drop-out (Carter
& Threlkeld, 2012). Research that explores the impact of solicitousness on treatment
adherence within an adult chronic pain population would be beneficial. Moreover,
intervention identifying what factors maintain solicitous responding from others whilst
providing patients with active self-management strategies to reduce the reliance on other
people to assist with pain is needed. Potential factors contributing to increased solicitousness
may include other pain-related cognitions such as poor pain self-efficacy (Molton et al.,
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2010). After review of the literature, further research is needed to more clearly establish
whether associations between pain-related cognitions (and other risk factors) and treatment
adherence exist. This knowledge will assist to advance rehabilitative practices whilst likely
reducing the risk of non-adherence and subsequent program re-admissions.
1.6.1.3 Perceived disability
The degree to which a patient believes that they are disabled by their pain, is another
powerful factor in the extent of their functional impairment (Glombiewski, Hartwish-Tersek
& Rief, 2010). A direct influence of such beliefs on behaviour and disability is seen in
patients who perceive themselves as more disabled, whereby, submaximal effort and lower
levels of function are often displayed (Luk et al., 2010). The opposite may also apply; pain
sufferers who suffer considerable functional impairment may consequently exhibit greater
perceptions of disability. The more disabled individuals perceive themselves to be, the less
likely that they will demonstrate maximal effort in performing prescribed self-management
strategies. Less proactive engagement in chronic pain management, in turn, may affect a
broader sense of biopsychosocial functioning; adversely impacting activities of daily living
(i.e., work, independent self-care, socialisation) and psychological wellbeing (Wong, Chow,
Chen, Wong & Fielding, 2015). Consequently, psychological features such as depressive
symptoms may be more likely to co-occur among individuals who perceive themselves as
more disabled and adversely affected by pain (Roh, Lee, Noh, Oh, Gong & Baek, 2012).
Although more research regarding this relationship is needed, the premise that perceived
disability and other related psychosocial factors can modify the pain experience and
likelihood of successful intervention is promising.
There is considerable literature examining perceived and/or actual disability among
chronic pain patients. However, (similar to other pain-related cognitions) much of the
literature tends to focus on examining disability in relation to treatment effectiveness (Pérez-
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Fernández et al., 2015; Luk et al., 2010), with less research exploring the relationship
between disability and treatment adherence specifically (Dobkin et al., 2010). Of the latter
research, understanding the direct effects of treatment adherence on disability outcomes have
been prioritised. Although, the impact of perceived disability on treatment adherence
outcomes have received less attention, there is some evidence to suggest that a relationship
exists between these variables. For example, Dobkin et al. (2010) found a moderate to strong
negative association between perceived disability and treatment adherence; whereby,
experiencing high perceived disability at baseline was associated with reduced adherence to
treatment recommendations post-intervention. Additional research examining this
relationship specifically would be useful to further clarify the influence of perceived
disability on chronic pain self-management post-intervention.
1.6.1.4 Catastrophising and fear-avoidance beliefs
With regard to cognitions and coping responses, a great deal of empirical research has
focused on catastrophising, which is characterised by unrealistic and excessively negative
self-statements in response to pain (e.g., labelling pain sensations as awful, horrible, and
unbearable; Parr et al., 2012; Linton & Shaw, 2011; Richardson et al., 2009). In studies
involving individuals with chronic pain, catastrophising and fear-avoidance beliefs (i.e., an
excessive fear of pain that can lead to avoidant behaviour) have been related to a variety of
negative outcomes, including greater pain intensity and pain interference (Doménech,
Sanchis-Alfonso & Espejo, 2014), poorer psychological functioning (Richardson et al.,
2009), and increased use of analgesics and healthcare services (Katz, Buis & Cohen, 2008).
This leads to the consideration of the fear avoidance model which was proposed to explain
why patients who are experiencing noxious or threatening stimuli reduce their activities
(Lethem et al., 1983). In this model, initial adaptive responses to threat become, over time,
maladaptive and are termed avoidance behaviours which have the potential to increase fear,
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pain, and limited activity. Based on this association, Vlaeyen and Linton (2000) proposed a
model of chronic pain where patient’s catastrophic thoughts and fear of movement beliefs can
lead to greater pain disability. This model suggests that fear of pain develops as a result of a
cognitive interpretation of pain as threatening (i.e. the result of pain catastrophising), which
affects attention processes (i.e. causing hypervigilance) leading to fear-avoidance behaviours,
followed by disability and potential psychopathology. Consequently, pain catastrophising and
fear avoidance have been associated with a variety of problems that hinder recovery, making
treatment more difficult and increasing the risk of developing chronic pain and disability
(Linton & Shaw, 2011).
Chronic pain patients presenting with a fear of pain may also report higher levels of
kinesiophobia (i.e., fear of movement and injury; Kori, Miller & Todd, 1990). In which case,
fear of pain is generalised to other situations that are closely linked to the feared stimulus.
This is found to be particularly pertinent among patients who develop chronic pain following
traumatic injury (Hudes, 2011). Individuals who are displaying fear-avoidance beliefs may
experience difficulty in returning to the place of injury, such as a work environment for
example. These individuals may then avoid performing tasks that are similar to those that
caused the initial injury and limit their participation in activities perceived to be harmful.
Over time, fear of pain is considered to result in musculoskeletal deconditioning, reducing
pain tolerance, and fewer attempts to overcome functional limitations. For example,
Doménech at al. (2014) found kinesiophobia and catastrophizing to predict higher ratings of
pain and disability in patients with chronic anterior knee pain. An accumulation of past
literature (Doménech et al., 2014; Parr et al., 2012; Wideman & Sullivan, 2011) supports the
significance of kinesiophobia and catastrophizing in maintaining unhelpful cycles of pain,
disability, and avoidance.
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There is some evidence to suggest that catastrophising and fear-avoidance beliefs may
also be predictive of poor treatment adherence (Nicholas et al., 2012; Mannion et al., 2009).
In addition, much of the research has examined catastrophising and fear-avoidance in relation
to treatment program effectiveness rather than treatment adherence specifically (Wertli,
Rasmussen-Bar, Held, Weiser, Bachmann & Brunner, 2014; George & Stryker, 2011) this is
also the case for other cognitive factors. More recently, Palazzo et al. (2016) found fear of
movement and false beliefs regarding exercises found to be associated with limited
adherence. Clearly, catastrophising and fear-avoidance beliefs are significant markers for the
development of persistent pain problems. Considerable research has highlighted the
importance of structure based education programmes to reduce fear and damage related pain
beliefs (Butler & Moseley, 2013; Louw, Diener, Butler & Puentedura, 2011; Clarke, Ryan &
Martin, 2011). However, a window of opportunity remains to further establish the impact of
these cognitive factors on treatment adherence.
1.6.1.5 Perceived control and belief in medical cure
Beliefs that one has the ability and resources to control pain (i.e., internal control) is
thought to enhance adjustment and coping; thereby, reducing impairment and improving
functioning (de Waal, Hegeman, Gussekloo, Verhaak, van der Mast & Comics, 2016).
Multidisciplinary rehabilitation has shown to be effective in enhancing perceived control
beliefs among chronic pain patients. This is illustrated in Keedy et al.’s (2014) study which
found participants to display an increased sense of personal control over their pain and
substantial decreases in external (i.e., powerful others) pain control attributions one month
following an intensive multidisciplinary program. Similar findings pertaining to the
importance of control beliefs are seen among other chronic populations (Howren, Cozad &
Christensen, 2016a; Law, Tolgyesi & Howard, 2014). Despite previous research identifying
control attributions among chronic pain populations (Baker et al., 2008), more recent research
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examining pain control beliefs is limited. It would be advantageous to build on the
connections outlined in the literature and investigate the nature of this phenomenon among
current chronic pain populations.
Along the lines of perceived control, external control can result in the belief that
medication can cure or control pain. Beliefs in medical cure for pain have been shown to be
associated with greater reliance on medication and use of rest (Karoly, Ruehlman & Okun,
2013). Certainly, using pain medication to control pain can be an adaptive response in some
instances. However, on other occasions it may serve as part of a pattern of avoidance of pain,
a pattern that could constrict daily functioning and lead to other health problems such as
opioid dependence (Jamison et al., 2010). Similar to perceived control, patients who believe
that pain can be cured by medication or powerful others (e.g., medical professional/s) may be
more likely to attend pain management programs and adhere to aspects of such programs that
target an immediate reduction in pain and/or fulfil their beliefs regarding appropriate
intervention (e.g., medication, surgery or other invasive procedures). However, other pain
management components that require patients to independently and routinely complete active
self-management strategies whilst targeting other aspects of quality of life and function may
not be given the same priority. That is, despite the tendency to comply with prescribed
medication treatment, these patients may be more likely to rely on maladaptive and passive
coping strategies such as medication, consequently exhibiting greater levels of psychological
distress and poorer functioning (Peres & Lucchetti, 2010). In terms of treatment adherence,
patients who rely on external (rather than internal) sources to treat their pain may be less
likely to engage in and maintain proactive self-management strategies (e.g., exercise).
Nicklas et al.’s (2010) cross-sectional study assessing chronic pain patient’s adherence to
treatment, found that a perception of pain as chronic, uncontrollable, and unremitting was
associated with a greater reliance on medication and a belief that pharmacological treatment
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was necessary. Future studies are needed to explore the role that perceived control and belief
in medical cure have on multidisciplinary treatment adherence. Interventions aimed at
shifting pain control beliefs from external (e.g., belief in medical cure) to internal (e.g.,
perceived control) may facilitate the use of more proactive methods of self-management
(Nicklas et al., 2010).
1.6.2 Co-morbid psychopathology
The co-morbidity of chronic pain and psychopathology is well known to contribute to
poorer outcomes for chronic pain patients (Chen, Cheng, Huang, Liu & Luo, 2012; Gormsen
et al., 2010). Research has demonstrated that physical and psychological symptoms increase
together, and as the number or severity of physical symptoms increases, so does the
likelihood of a psychological disorder (Linton & Shaw, 2011). This holds true for pain
symptoms with and without a diagnosable aetiology (i.e., fibromyalgia; Gormsen et al.,
2010). There are several reasons why it is important to identify co-morbid psychopathology
in chronic pain patients. Firstly, unrecognised and untreated co-morbid psychopathology can
significantly interfere with successful rehabilitation of these patients (Pompili et al., 2012).
Secondly, poor psychological health may also increase pain intensity and disability, thus
serving to perpetuate pain-related dysfunction (Glombiewski et al., 2010). Thirdly, many
chronic pain patients are exposed to traumatic injury and compensation or litigation stress
which is frequently associated with psychological symptoms, thus worsening patient outcome
(Elbers et al., 2012).
Many disorders have been found to co-occur with chronic pain, including depression
(Ang, Bair, Damush, Wu, Tu & Kroenke, 2010), anxiety (Asmundson & Katz, 2009), Post-
Traumatic Stress Disorder (PTSD; Phifer et al., 2011), substance abuse (Boscarino, Rukstalis,
Hoffman, Han, Erlich & Ross, 2011) as well as some personality disorders (Sansone &
Sansone, 2012). Of those listed, co-morbid depression is most commonly reported, however,
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some questions remain regarding its aetiology. Anxiety is also frequently shown to co-occur
among chronic pain patients, according to recent research and clinical reports. Based on these
findings, a review of the literature concerning co-morbid depression and anxiety will each be
presented.
1.6.2.1 Depression and chronic pain
The association between chronic pain and depression is well known, receiving the
most research and theoretical attention (Ang et al., 2010; Asghari, Julaeiha & Godarsi, 2008;
Elliot, Renier & Palcher, 2003). However, this relationship is complex, and the findings have
been widely divergent. Depression is a condition of mental disturbance, typically presenting
as lack of energy and difficulty in maintaining concentration or interest in life, and often
includes feelings of hopelessness and inadequacy (Chen et al., 2012). A review of several
large population studies showed mood disorders of various types (i.e., Major Depressive
Disorder, depressive episode, dysthymia) to be two to seven times more prevalent among
chronic pain sufferers (Tunks, Crook & Weir, 2008). And controversy still exists as to
whether depression is an antecedent or a consequence of chronic pain (Kroenke et al., 2012).
It is likely that there is a bi-directional relationship involved. Assessment of depression in
chronic pain patients has been further complicated by overlapping symptomatology. That is,
the diagnostic criteria for Major Depressive Disorder (MDD) include several somatic
symptoms that can also be attributed to chronic pain (e.g., sleep disturbance, loss of energy,
motor retardation; Ang et al., 2010). Therefore, diagnosing depression in chronic pain
populations is not always straightforward.
Various research studies suggest that the association between depression and chronic
pain may be strengthened by unhelpful cognitions (Glombiewski et al., 2010; Baker et al.,
2008), in particular, poor pain self-efficacy (Craig et al., 2013). The accumulation of
literature provides substantial support for a correlation between depression and pain self-
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efficacy, with positive self-efficacy shown to directly reduce vulnerability to co-morbid
depression among chronic pain patients (Craig et al., 2013; Miró et al., 2011). Whereby, more
self-efficacious patients show a greater tolerance of pain and less depressive
symptomatology. Studies elaborating on this relationship suggest that pain patients with co-
morbid depression are more likely to evaluate their performance and ability to cope with pain
more negatively than their non-depressed counterparts (Ang et al., 2010). Due to a lack of
self-belief, these patients are less likely to demonstrate necessary coping strategies to
effectively manage pain; thereby, impeding future opportunities to gain confidence,
maintaining pain-related disability, and limiting the release of ‘feel good’ chemical
neurotransmitters (e.g., serotonin) important for psychological wellbeing (Chen et al., 2012).
Consequently, a cycle of low self-confidence, passive coping and depression may be more
likely to ensue. Several research findings support the importance of pain self-efficacy for
depression above and beyond other known contributing factors. For example, Asghari et al.’s
(2008) study found pain self-efficacy to be more strongly related to depression and associated
disability than pain intensity and demographic variables. Research is needed to continue to
build a better understanding of pain self-efficacy and its relative impact on co-morbid
depression which may, in turn, lead to improved treatment and prevention.
Depression is a major barrier to effective pain management, amplifying the
experience and perception of pain (Linton & Shaw, 2011). Many longitudinal studies have
illustrated this, with depressed individuals more likely to develop multiple pain symptoms
and greater levels of pain (on self-report pain intensity measures), than non-depressed
subjects over time (Kroenke, Wu, Bair, Krebs, Damush & Tu, 2011; Hawker et al., 2011).
This may be due, in part, to depressed chronic pain patients engaging less in proactive self-
management strategies (e.g., physical activity) and more in passive coping (i.e., surrendering
control over pain) than their non-depressed counterparts (Kroenke et al., 2011). That is,
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depressed patients may adopt a helpless attitude toward their pain and use more negative self-
statements, increasing the experience of pain as well as the disability interference (Hawker et
al., 2011). Heightened levels of depression post-treatment may, therefore, put individuals at
greater risk of exhibiting poor adherence behaviour and subsequent relapse of pain
symptoms. A greater understanding of what factors contribute to co-morbid depression
among chronic pain patients is needed to improve intervention and post-treatment outcomes.
While it may not be realistic for presentations of clinical depression to be properly treated
during a time-limited pain management program, it is important that patients receive the
skills necessary to enable them to independently manage chronic pain, despite episodes of
low mood. In addition to receiving adequate community support for ongoing treatment for
depression. As a result, pain-related disability may be reduced and psychological wellbeing
inadvertently improved.
1.6.2.2 Anxiety and chronic pain
Chronic pain is frequently associated with anxiety symptoms. This is not surprising
given that many pain conditions are acquired as a result of traumatic injury (e.g., motor
vehicle accidents, military combat; Demir et al., 2010; Norman, Stein, Dimsdale & Hoyt,
2007). A growing number of studies have examined the prevalence and nature of comorbid
chronic pain and anxiety disorders (Kroenke et al., 2013; Asmundson & Katz, 2009);
however, the majority of this research has focused on Panic Disorder (PD) and Post-
Traumatic Stress Disorder (PTSD) specifically (Phifer et al., 2011; Hofmann et al., 2012).
According to Otis et al., (2003), 30% of PTSD community outpatients and 50-80% of
military veterans and volunteer firefighters with PTSD report comorbid chronic pain. More
recently, Phifer et al. (2011) found patients with co-morbid chronic pain and PTSD reported
greater pain-related impairment in addition to increased prescribed opioid use for pain
control, compared to patients with chronic pain alone. What adds to the complexity in
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understanding this relationship are the shared cognitive, behavioural and physiological
response patterns among PTSD and chronic pain (Bosco, Gallinati & Clark, 2013). For
example, both are characterised by somatic hypervigilance, biases in attention toward
threatening stimuli and avoidance behaviours, among other overlapping symptoms
(Asmundson & Katz, 2009). Despite this, these findings provide further support for the
impact that emotional interpretation and response to painful stimuli can have on coping
ability and outcome.
Similar to depression, there may be several factors that contribute to the development
and maintenance of co-morbid pain and anxiety (Asmundson & Katz, 2009). According to
several authors, fear-avoidance beliefs are the most frequently associated maladaptive
cognition among patients with co-morbid chronic pain and anxiety (Hasenbring, Chehadi,
Titze & Kreddig, 2014; Bailey, Carleton, Vlaeyen & Asmundson, 2010). Chronic pain
patients may develop fear and avoidance of movements or activities that they perceive to
exacerbate pain. Similarly, for a person with anxiety, fear of re-experiencing disturbing
thoughts or events and avoidance of reminders associated with the trauma are core
components of the disorder. This fear and avoidance can prevent effective processing of the
event and may lead to the maintenance of intrusive symptoms and arousal (Bailey et al.,
2010). In this way, fear-avoidance beliefs serve to mutually maintain co-morbid chronic pain
and anxiety. By helping patients to resolve unhelpful fear-avoidance beliefs, treatment of
these patients may be more effective.
Given the interference caused by persistent co-morbid anxiety and chronic pain, it is
understandable that adherence to strategies for pain management would be considerably
difficult. There is some research in support of this; whereby, increased anxiety symptoms
have been found to predict poor treatment adherence (Nicklas et al., 2010). However, there
are relatively few studies examining the impact of anxiety on treatment adherence among
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samples of chronic pain patients specifically. Of the literature that does exist, findings are
invariably mixed. Whereas, a systematic review conducted by Jack et al. (2010) found
evidence (2 of 20 high quality trials) that low treatment adherence was associated with
anxiety (among other factors), other studies show no association between anxiety and
treatment adherence (Arrieta et al., 2013). Further examination of the links between these
variables is needed to elucidate the importance of anxiety in predicting adherence behaviour
among chronic pain patients. This knowledge will hopefully allow for more refined methods
of intervention and better utilisation of treatment resources.
1.6.3 Summary
From this research, various psychosocial factors are shown to be important predictors
of chronic pain and associated outcomes. Of the pain-related cognitions reviewed, pain self-
efficacy has received the most attention in regards to chronic pain management (Menezes
Costa et al., 2011). Depression and anxiety are also found to frequently co-occur among
chronic pain patients (Artner et al., 2012). The interrelationships between psychological and
cognitive factors associated with chronic pain have also been emphasised (Kamper et al.,
2015). By identifying the psychosocial factors and the interrelationships between them that
influence how people with chronic pain adapt and cope, intervention may be better refined
for individual needs. Additional consideration of the impact that various psychosocial factors
have on self-management behaviour post-intervention is also important. Ongoing research
into the effects of pain-related cognitions, especially pain self-efficacy, and psychological
factors including depression and anxiety on chronic pain and adherence behaviour is
encouraged.
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1.7 Summary and Rationale
Based on the accumulation of previous research, intervention should be targeted at
overcoming psychosocial factors such as unhelpful belief systems and co-morbid
psychopathology, given their potential to improve treatment and disability outcomes. The
present research contributes three empirical studies to the literature on this topic. The
rationale, aims, and methodology for each study will be introduced, in turn.
1.7.1 Study One
The rationale for Study One was two-fold. Firstly, limited research investigating the
interrelationships between chronic pain, cognitions, and treatment adherence concurrently
was evident. Secondly, a large majority of the chronic pain literature was found to focus on
pharmacological adherence with considerably fewer studies investigating the effects of pain-
related cognitions on multidisciplinary intervention. The aim of Study One was to conduct a
systematic review of empirical studies which have examined the associations between
cognitions and treatment adherence among chronic pain patients attending multidisciplinary
pain management intervention. More specifically, Study One sought to address the following
two questions. Firstly, which pain-related cognitions predict increased treatment adherence
during a multidisciplinary program? Secondly, to what extent do these pain-related cognitions
influence adherence to treatment recommendations post-treatment? Three combinations of
keywords (‘chronic pain’, ‘beliefs’ and ‘treatment adherence’) and their relevant MeSH
terms, subject headings, text words, and word variants were searched against five electronic
databases (Medline, CINAHL, PsycINFO, Academic Search Complete and Scopus). Study
One was accepted for publication in the Clinical Journal of Pain (Thompson, Broadbent,
Bertino, & Staiger, 2016).
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1.7.2 Study Two
The rationale for Study Two was centred on the lack of research found to examine
various specific cognitive factors (i.e., pain self-efficacy, fear-avoidance beliefs, perceived
control, perceived disability) as predictors of affective disorder symptoms severity (i.e.,
depression, anxiety) within the same conceptual model. Study Two aimed to identify the key
cognitive contributors to the co-morbidity of chronic pain and affective disorder symptoms
using a novel network model. Based on prior research, it was hypothesised that all of the
pain-related cognitions assessed would be inter-related, and also relate to pain intensity and
affective disorder symptom severity. It was further hypothesised that pain intensity would be
related to affective disorder symptoms. Cross-sectional by design, Study Two comprised 169
chronic pain patients receiving multidisciplinary treatment intervention. Participants
completed a battery of questionnaires (DASS-21, PSEQ, TAMPA, SOPA-R, and PDI) at
admission via self-report measures. Study Two is currently under review for publication in
the British Journal of Health Psychology.
1.7.3 Study Three
The rationale for Study Three was based on the limited data found to exist comparing
the interrelationships of multiple cognitive and psychological factors on adherence to
multidisciplinary recommendations post-treatment. Similarly, the appropriate time to measure
psychosocial factors and their predictive value on post-treatment adherence had also received
little attention. Study Three aimed to longitudinally evaluate the influence of psychological
factors (anxiety, depression, fear avoidance, and pain self-efficacy) in predicting treatment
adherence post-intervention. Study Three hypothesised that: (1) adherence post-intervention
follow-up would be lower for individuals with higher depression, anxiety, and fear avoidance
tendencies, and lower self-efficacy at pre-intervention (Hypothesis 1) and post-intervention
(Hypothesis 2); (2) post-intervention levels of the risk factors would be better predictors than
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their pre-intervention levels for predicting adherence in the post-intervention phase
(Hypothesis 3); and (3) the relationship between risk factors and adherence would be
moderated by change in risk factors exhibited during the treatment phase (Hypothesis 4).
Study Three comprised 61 chronic pain patients who had completed a multidisciplinary pain
management program. Participants completed a battery of questionnaires (DASS-21, PSEQ,
TAMPA, and TMQ) at three time-points (admission, discharge, and 3-6 month follow-up) via
self-report measures. Study Three is currently under review for publication in Clinical
Psychologist.
1.8 Conclusion
Chronic pain is a significant health problem which has been found to impact several
areas of an individual’s biological, psychological, and social functioning (Goldberg &
McGee, 2011). For this reason, a biopsychosocial perspective has become the most widely
adopted heuristic to conceptualise chronic pain (Gatchel et al., 2007). Through the
development of research, a greater understanding of the importance of psychosocial factors
has been established. Since then, research of cognitive and psychological factors has
proliferated and several pain-related cognitions and diagnosable psychopathology have been
found to co-occur among chronic pain patients (Kamper et al., 2015). These psychosocial
factors are consistently found to predict poor disability and treatment outcomes. Therefore,
clinicians conducting diagnostic assessments of patients with chronic pain are required to
assess for both co-morbid psychopathology and pain-related cognitions to gain a
comprehensive understanding of the factors contributing to and maintaining poor pain-related
outcomes (Linton & Shaw, 2011). Recent research has indicated the need for pain
management to be flexible and holistic, focusing on patient’s wellness and monitoring
significant markers of poor adherence post-treatment (Kamper et al., 2015). On review of the
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current literature, an increased awareness of the risk factors that may lead to the persistence
of chronic pain, particularly the interrelationships among cognitive and psychological
features that contribute to poor self-management and treatment maintenance is needed.
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References
Ablin, J. N., Buskila, D., Van Houdenhove, B., Luyten, P., Atzeni, F & Sarzi-Puttini, P.
(2012). Is fibromyalgia a discrete entity? Autoimmunity Reviews, 11(8), 585-588.
Alschuler, K. N., Theisen-Goodvich, M. E., Haig, A. J & Geisser, M. E. (2008). A
comparison of the relationship between depression, perceived disability, and physical
performance in persons with chronic pain. European Journal of Pain, 12(6), 757-764.
Ang, D. C., Bair, M. J., Damush, T. M., Wu, J., Tu, W & Kroenke, K. (2010). Predictors of
pain outcomes in patients with chronic musculoskeletal pain co-morbid with depression:
Results from a randomized controlled trial. Pain Medicine, 11(4), 482-491.
Arrieta, Ó., Angulo, L. P., Núňez-Valencia, C., Dorantes-Gallaretta, Y., Macedo, E. O.,
Martinez-López, D., et al. (2013). Association of depression and anxiety on quality of life,
treatment adherence, and prognosis in patients with advanced non-small cell lung cancer.
Annuals of Surgical Oncology, 20(6), 1941-1948.
Asghari, A., Julaeiha, S., & Godarsi, M. (2008). Disability and depression in patients with
chronic pain: pain or pain-related beliefs? Archives of Iranian Medicine, 11(3), 236-239.
Asmundson, G. J. G., & Katz, J. (2009). Understanding the co-occurrence of anxiety
disorders and chronic pain: State of the art, Depression and Anxiety, 26(10), 229-244.
Arthritis and Osteoporosis Victoria. (2013). A problem worth solving. Elsternwick: Arthritis
and Osteoporosis Victoria.
Artner, J., Lattig, F., Cakir, B., Gündel, H., Reichel, H & Spiekermann, J. A. (2012).
Prevalence of mental health disorders in multimodal therapy of chronic back pain.
Orthopade, 41(12), 950-957.
![Page 57: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/57.jpg)
43
Azevedo, L. F., Pereira, A., Mendonca, L., Dias, C. C & Castro-Lopes, J. M. (2012).
Epidemiology of chronic pain: A population-based nationwide study on its prevalence:
characteristics and associated disability in Portugal, The Journal of Pain, 13(8), 773-783.
Bailey, K. M., Carleton, N. R., Vlaeyen, J. W. S & Asmundson, G. J. G. (2010). Treatments
addressing pain-related fear and anxiety in patients with chronic musculoskeletal pain: A
preliminary review. Cognitive Behaviour Therapy, 39(1), 46-63.
Baker, T. A., Buchanan, N. T & Corson, N. (2008). Factors influencing chronic pain intensity
in older black women: examining depression, locus of control, and physical health.
Journal of Women’s Health, 17(5), 869-878.
Ballantyne, J. C & Sullivan, M. D. (2015). Intensity of chronic pain – The wrong metric? The
New England Journal of Medicine, 373(22), 2098-2099.
Bandura, A. (1977). Self-efficacy: Toward a unifying theory of behavioural change.
Psychological Review, 84(2), 191-215.
Bean, D. J., Johnson, M. H., Heiss-Dunlop, W., Lee, A. C & Kydd, R. R. (2015). Do
psychological factors influence recovery from complex regional pain syndrome type 1? A
prospective study. Pain, 156(11), 2310-2318.
Berger, M. Y., Gieteling, M. J & Benninga, M. A. (2007). Chronic abdominal pain. British
Medical Journal, 334(7601), 997-1002.
Björnsdóttir, S. V., Jónsson, S. H & Valdimarsdóttir, U. A. (2013). Functional limitations and
physical symptoms of individuals with chronic pain. Scandinavian Journal of
Rheumatology, 42(1), 59-70.
Blyth, F. M., March, L. M., Brnabic, A. J. M., Jorm, L. R., Williamson, M & Cousins, M. J.
(2001). Chronic pain in Australia: a prevalence study. Pain, 89(2-3), 127-134.
![Page 58: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/58.jpg)
44
Boonstra, A. M., Preuper, H. R. S., Reneman, M. F., Posthumus, J. B &Stewart, R. E. (2008).
Reliability and validity of the visual analogue scale for disability in patients with chronic
musculoskeletal pain. International Journal of Rehabilitation Research, 31(2), 165-169.
Boscarino, J. A., Rukstalis, M. R., Hoffman, S. N., Han, J. J., Erlich, P. M & Ross, S. (2011).
Prevalence of prescription opioid-use disorder among chronic pain patients: Comparison
of the DSM-5 vs. DSM-4 diagnostic criteria. Journal of Addictive Diseases, 30(3), 185-
194.
Bosco, M. A., Gallinati, J. L & Clark, M. E. (2013). Conceptualizing and treating comorbid
chronic pain and PTSD. Pain Research and Treatment, 2013, 174728.
Bruehl, S. (2015). Complex regional pain syndrome. British Medical Journal, 351, 1-13.
Buse, D. C., Manack, A. N., Fanning, K. M., Serrano, D., Reed, M. L., Turkel,C. C., et al.
(2012). Chronic migraine prevalence, disability, and sociodemographic factors: Results
from the American migraine prevalence and prevention study. The Journal of Head and
Face Pain. 52(10), 1456-1470.
Cano, A., Barterian, J. A & Heller, J. B. (2008). Empathic and non-empathic interaction in
chronic pain couples. Clinical Journal of Pain, 24(8), 678-684.
Carnes, D., Parsons, S., Ashby, D., Breen, A., Foster, N. E., Pincus, T., et al. (2007). Chronic
musculoskeletal pain rarely presents in a single body site: results from a UK population
study. Rheumatology, 46(7), 1168-1170.
Carter, B. D & Threlkeld, B. M. (2012). Psychosocial perspectives in the treatment of
pediatric chronic pain. Pediatric Rheumatology Online Journal, 10(1), 10-15.
Casey, C. Y., Greenberg, M. A., Nicassion, P. M., Harpin, E. R & Hubbard, D. (2008).
Transition from acute to chronic pain and disability: A model including cognitive,
affective, and trauma factors. Pain, 134(1-2), 69-79.
![Page 59: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/59.jpg)
45
Cheatle, M., Comer, D., Wunsch, M., Skoufalos, A & Reddy, Y. (2014). Treating pain in
addicted patients: Recommendations from an expert panel. Population Health
Management, 17(2), 79-89.
Chen, X., Cheng, H. G., Huang, Y., Liu, Z., & Luo, X. (2012). Depression symptoms and
chronic pain in the community population in Beijing. China, Psychiatry Research, 200(2-
3), a2718.
Clarke, C. L., Ryan, C. G & Martin, D. J. (2011). Pain neurophysiology education for the
management of individuals with chronic low back pain: systematic review and meta-
analysis. Manual Therapy, 16(6), 544-549.
Cohen, S. P., Argoff, C. E & Carragee, E. J. (2008). Management of low back pain. British
Medical Journal, 337, 100-106.
Coppack, R. J., Kristensen, J & Karaheorghis, C. I. (2012). Use of goal setting intervention to
increase adherence to low back pain rehabilitation: A randomized control trial. Clinical
Rehabilitation, 26(11), 1032-1042.
Costa, L. C. M., Maher, C. G., McAuley, J. H., Hancock, M. J & Smeets, R.J. E. M. (2011).
Self-efficacy is more important than fear of movement in mediating the relationship
between pain and disability in chronic low back pain. European Journal of Pain, 15(2),
213-219.
Craig, A., Tran, Y., Siddall, P., Wijesuriya, N., Lovas, J., Bartrop, R., et al. (2013).
Developing a model of associations between chronic pain, depressive mood, chronic
fatigue, and self-efficacy in people with spinal cord injury. The Journal of Pain, 14(9),
911-920.
Crombez, G., Eccleston, C., Van Damme, S., Vlaeyen, J & Karoly, P. (2012). Fear-avoidance
model of chronic pain: The next generation. The Clinical Journal of Pain, 28(6), 475-483.
![Page 60: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/60.jpg)
46
Deandrea, S., Lucenteforte, E., Bravi, F., Foschi, R., La Vecchia, C & Negri, E. (2010). Risk
factors for falls in community-dwelling older people: A systematic review and meta-
analysis. Epidemiology, 21, 658-668.
Demir, S. E., Özaras, N., Karamehmetoğlu, S. S., Karacan, İ & Aytekin, E. (2010). Risk
factors for complex regional pain syndrome in patients with traumatic extremity injury.
Turkish Journal of Trauma & Emergency Surgery, 16(2), 144-148.
de Rooij, A., Steultjens, M. P. M., Siemonsma, P. C., Vollebregt, J. A., Roorda, L. D.,
Beuving, W., et al. (2011). Overlap of cognitive concepts in chronic widespread pain: An
exploratory study. BMC Musculoskeletal Disorders, 12(218), 1-8.
de Waal, M. W., Hegeman, J. M., Gussekloo, J., Verhaak, O. F., van der Mast R. C &
Comics, H. C. (2016). The effect of pain on presence and severity of depressive disorders
in older persons: The role of perceived control as mediator. Journal of Affective Disorders.
197, 239-244.
Dieppe, P. (2012). Chronic musculoskeletal pain. In Colvin, L. A & Fallon, M(Eds.), ABC of
Pain (1st edition, pp.16-19). UK: Wiley.
Dimsdale, J. E., Creed, F., Escobar, J., Sharpe, M., Wulsin, L., Barsky, A., et al. (2013).
Somatic symptom disorder: An important change in DSM. Journal of Psychosomatic
Research, 75(3), 223-228.
Dobkin, P. L., Liu, A., Abrahamowicz, M., Ionescu-Ittu, R., Bernatsky, S., Goldberger, A., el
al. (2010). Predictors of disability and pain six months after the end of treatment for
fibromyalgia. The Clinical Journal of Pain, 26(1), 23-29.
Doménech, J., Sanchis-Alfonso, V & Espejo, B. (2014). Changes in catastrophizing and
kinesiophobia are predictive of changes in disability and pain after treatment in patients
with anterior knee pain. Knee Surgery, Sports Traumatology, Arthroscopy, 22(10), 2295-
2300.
![Page 61: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/61.jpg)
47
Driscoll, M. A & Kerns, R. D. (2016). Integrated, team-based chronic pain management:
Bridges from theory and research to high quality patient care. In Chao, M & Huang, Y
(Eds.), Translational Research in Pain and Itch: Advances in Experimental Medicine and
Biology (pp.59-75). Springer.
Dworkin, R. H., Turk, D. C., McDermott, M. P., Peirce-Sandner, S., Burke, L. B., Cowan, P.,
et al. (2009). Interpreting the clinical importance of group differences in chronic pain
clinical trials: IMMPACT recommendations. Pain, 146(3), 238-244.
Elbers, N. A., Hulst, L., Cuijpers, P., Akkermans, A. J., & Bruinvels, D. J. (2012). Do
compensation processes impair mental health? A meta-analysis. Injury: International
Journal of the Care of the Injured, 44(5), 1-10.
Elliot, T. E., Renier, C. M & Palcher, J. A. (2003). Chronic pain, depression, and quality of
life: Correlations and predictive value of the SF-36. Pain Medicine, 4(4), 331-339.
Elzahaf, R. A., Tashani, O. A., Unsworth, B. A & Johnson, M. I. (2012). The prevalence of
chronic pain with an analysis of countries with a human development index less than 0.9:
A systematic review without meta-analysis. Current Medical Research and Opinion,
28(7), 1221-1229.
Escolar-Reina, P., Medina-Mirapeix, F., Gascón-Cánovas, J. J., Montilla-Herrador, J.,
Jimeno-Serrano, F. J., de Oliveira Sousa, S. L., et al. (2010). How do care-provider and
home exercise program characteristics affect patient adherence in chronic neck and back
pain: a qualitative study. BMC Health Services Research, 10, 60.
Fayaz, A., Croft, P., Langford, R. M., Donaldson, L. J & Jones, G. T. (2015). Prevalence of
chronic pain in the UK: A systematic review and meta-analysis of population studies. BMJ
Open, 6(6), e010364.
![Page 62: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/62.jpg)
48
Fedoroff, I. C., Blackwell, E & Speed, B. (2014). Evaluation of group and individual change
in a multidisciplinary pain management program. Clinical Journal of Pain, 30(5), 399-
408.
Fishbain, D. A., Goldberg, M., Meagher, R. B., Steele, R & Rosomoff, H. (1986). Male and
female chronic pain patients categorized by the DSM-III psychiatric diagnostic criteria.
Pain, 26(2), 181-197.
Fishbain, D. A., Lewis, J. E & Gao, J. (2015). The pain-suffering association, a review. Pain
Medicine, 16(6), 1057-1072.
Franklin, G. M., Rahman, E. A., Turner, J. A., Daniell, W. E & Fulton-Kehoe, D. (2009).
Opioid use for chronic low back pain: A prospective, population-based study among
injured workers in Washington State, 2002-2005. The Clinical Journal of Pain, 25(9),
743-751.
Gaskin, D. J & Richard, P. (2012). The economic costs of pain in the United States. The
Journal of Pain, 13(8), 715-724.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N & Turk, D. C. (2007). The
biopsychosocial approach to chronic pain: Scientific advances and future directions.
Psychological Bulletin, 133(4), 581-624.
Gatchel, R. J., McGeary, D. D., McGeary, C. A & Lippe, B. (2014). Interdisciplinary chronic
pain management: past, present, and future. The American Psychologist, 69(2), 119-130.
George, S. Z & Stryker, S. E. (2011). Fear-avoidance beliefs and clinical outcomes for
patients seeking outpatient physical therapy for musculoskeletal pain conditions. Journal
of Orthopaedic & Sports Physical Therapy, 41(4), 249-259.
Ghadiyani, L., Tavafian, S. S., Kazemnejad, A & Wagner, J. (2017). Effectiveness of
multidisciplinary group-based intervention versus individual physiotherapy for improving
![Page 63: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/63.jpg)
49
chronic low back pain in nursing staff: A clinical trial with 3- and 6-month follow-up
visits from Tehran, Iran. Asian Spine Journal, 11(3), 396-404.
Glombiewski, J. A., Hartwich-Tersek, J & Rief, W. (2010). Attrition in cognitive-behavioral
treatment of chronic back pain. Clinical Journal of Pain, 26(7), 593-601.
Glombiewski, J. A., Hartwich-Tersek, J & Rief, W. (2010). Depression in chronic back pain
patients: Prediction of pain intensity and pain disability in cognitive-behavioral treatment.
Psychosomatics, 51(2), 130-136.
Goldberg, D. S & McGee, S. J. (2011). Pain as a global public health priority. BMC Public
Health, 6(11), 1-5.
Gore, M., Sadosky, A., Stacey, B. R., Tai, K & Leslie, D. (2012). The burden of chronic low
back pain. SPINE, 37(1), e668-e677.
Gormsen, L., Rosenberg, R., Bach, F. W & Jensen, T. S. (2010). Depression, anxiety, health-
related quality of life and pain in patients with chronic fibromyalgia and neuropathic pain.
European Journal of Pain, 14(2), 127.e1-127.e8.
Graven-Nielsen, T & Arendt-Nielsen, L. (2010). Assessment of mechanisms in localized and
widespread musculoskeletal pain. Nature Reviews Rheumatology, 6(10), 599-606.
Harden, N. R., Bruehi, S., Perez, R. S. G. M., Birklein, F., Marinus, J., Maihofner, C., et al.
(2010). Development of a severity score for CRPS. Pain, 151, 870-876.
Harris, I. A., Young, J. M., Rae, H., Jalaludin, B. B & Solomon, M. J. (2007). Factors
associated with back pain after physical injury: A survey of consecutive major trauma
patients. Spine, 32 (14), 1561-1565.
Hasenbring, M. I., Chehadi, O., Titze, C & Kreddig, N. (2014). Fear and anxiety in the
transition from acute to chronic pain: there is evidence for endurance besides avoidance.
Pain Management, 4(5), 363-374.
![Page 64: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/64.jpg)
50
Hawker, G. A., Gignac, M. A. M., Badley, E., Davis, A. M., French, M. R., Li, Y., et al.
(2011). A longitudinal study to explain the pain-depression link in older adults with
osteoarthritis. Arthritis Care and Research, 63(10), 1382-1390.
Heiskanen, T., Roine, R. P & Kalso, E. (2012). Multidisciplinary pain treatment – Which
patients do benefit? Scandinavian Journal of Pain, 3(4), 201-207.
Henderson, J. V., Harrison, C. M., Britt, H. C., Bayram, C. F & Miller, G. C. (2013).
Prevalence, causes, severity, impact, and management of chronic pain in Australian
general practice patients. Pain Medicine, 14(9), 1346-1361.
Hiller, W., Heuser, J & Fichter, M. M. (2000). The DSM-IV nosology of chronic pain: a
comparison of pain disorder and multiple somatization syndrome. European Journal of
Pain, 4(1), 45-55.
Hjermstad, M. J., Fayers, P. M., Haugen, D. F., Caraceni, A., Hanks, G. W., Loge, J. H., et al.
(2011). Studies comparing numerical rating scales, verbal rating scales, and visual
analogue scales for assessment of pain intensity in adults: A systematic review. Journal of
Pain and Symptom Management, 41(6), 1073-1093.
Hofmann, S. G., Asnaani, A., Vonk, I. J. J., Sawyer, A. T & Fang, A. (2012). The efficacy of
cognitive behavioral therapy: A review of meta-analyses. Cognitive Therapy Research,
36(5), 427-440.
Howren, M. B., Cozad, A. J & Christensen, A. J. (2016a). The interactive effects of patient
control beliefs on adherence to fluid-intake restrictions in hemodialysis: Results from a
randomized controlled trial. Journal of Health Psychology, [Epub ahead of print].
Hudes, K. (2011). The Tampa Scale of Kinesiophobia and neck pain, disability and range of
motion: a narrative review of the literature. The Journal of the Canadian Chiropractic
Association, 55(3), 222-232.
![Page 65: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/65.jpg)
51
Innes, S. I. (2005). Psychosocial factors and their role in chronic pain: A brief review of
development and current status. Chiropractic & Osteopathy, 13(6), 1-5.
Jack, K., McLean, S. M., Moffett, J. K & Gardiner, E. (2010). Barriers to treatment
adherence in physiotherapy outpatient clinics: A systematic review. Manual Therapy,
15(3), 220-228.
Jackson, T., Wang, Y., Wang, Y & Fan, H. (2014). Self-efficacy and chronic pain outcomes:
a meta-analytic review. The Journal of Pain, 15(8), 800-814.
Jamison, R. N., Ross, E. L., Michna, E., Chen, L. Q., Holcomb, C., Wasan, A. D., et al.
(2010). Substance misuse treatment for high-risk chronic pain patients on opioid therapy:
A randomized trial. Pain, 150(3), 390-400.
Järemo, P., Arman, M., Gerdle, B., Larsson, B & Gottberg, K. (2017). Illness beliefs among
patients with chronic widespread pain – associations with self-reported health status,
anxiety and depressive symptoms and impact of pain. BMC Psychology, 5(24), 1-10.
Jensen, M. P., Moore, M. R., Bockow, T. B., Ehde, D. M & Engel, J. M. (2011).
Psychosocial factors and adjustment to chronic pain in persons with physical disabilities:
A systematic review. Archives of Physical Medicine Rehabilitation, 92(1), 146-160.
Jensen, M. P., Turner, J. A & Romano, J. M. (2007). Changes after multidisciplinary pain
treatment in patient pain beliefs and coping are associated with concurrent changes in
patient functioning. Pain, 131(1-2), 38-47.
Johannes, C. B., Le, K. T., Zhou, X., Johnston, J. A & Dworkin, R. H. (2010). The
prevalence of chronic pain in United States adults: Results of an internet-based survey.
The Journal of Pain, 11(11), 1230-1239.
Juniper, M., Le, T. K & Mladsi, D. (2009). The epidemiology, economic burden, and
pharmacological treatment of chronic low back pain in France, Germany, Italy, Spain and
the UK: a literature-based review. Expert Opinion and Pharmacology, 10(16), 2581-2592.
![Page 66: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/66.jpg)
52
Kaiser, G. L. (2012). Chronic abdominal pain. In Symptoms and signs in pediatric surgery
(pp. 313-314). Berlin: Springer.
Kaiser, U., Arnold, B., Pfingsten, M., Nagel, B., Lutz, J & Sabatowski, R. (2013).
Multidisciplinary pain management programs. Journal of Pain Research, 6, 355-358.
Kamaleri, Y., Natvig, B., Ihlebaek, C. M & Bruusgaard, D. (2008). Localized or widespread
musculoskeletal pain: Does it matter? Pain, 138(1), 41-46.
Kamper, S. J., Apeldoorn, A. T., Chiarotto, A., Smeets, R. J. E. M., Ostelo, R. W. J. G.,
Guzman, J., et al. (2015). Multidisciplinary biopsychosocial rehabilitation for chronic low
back pain: Cochrane systematic review and meta-analysis. BMJ, 3-11.
Karoly, P., Ruehlman, L. S & Okun, M. A. (2013). Psychosocial and demographic correlates
of employment vs disability status in a national community sample of adults with chronic
pain: toward a psychology of pain presenteeism. Pain Medicine, 14(11), 1698-1707.
Katz, J., Buis, T & Cohen, L. (2008). Locked out and still knocking: predictors of excessive
demands for postoperative intravenous patient controlled analgesia. Canadian Journal of
Anesthesia, 55(2), 88-99.
Keedy, N. H., Keffala, V. J., Altmaier, E. M & Chen, J. J. (2014). Health locus of control and
self-efficacy predict back pain rehabilitation outcomes. The Iowa Orthopaedic Journal,
34, 158-165.
Kindler, L. L., Jones, K. D., Perrin, N & Bennett, R. M. (2010). Risk factors predicting the
development of widespread pain from chronic back or neck pain. Journal of Pain, 11(12),
1320-1328.
Koele, R., Volker, G., van Vree, F., van Grestel, M., Köke, A & Vliet Vlieland, T. (2014).
Multidisciplinary rehabilitation for chronic widespread pain: Results from daily practice.
Musculoskeletal Care, 12(4), 210-220.
![Page 67: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/67.jpg)
53
Koloski, N. A., Jones, M., Kalantar, J., Weltman, M., Zaguirre, J & Talley,N. J. (2012). The
brain-gut pathway in functional gastrointestinal disorders is bidirectional: A 12-year
prospective population-based study. Gut, 61(9), 1284-1290.
Kori, S. H., Miller, R. P & Todd, D. D. (1990). Kinesiophobia: A new view of chronic pain
behaviour. Pain Management, 3, 35-43.
Krein, S. L., Heisler, M., Piette, J. D., Butchart, A & Kerr, E. A. (2007). Overcoming the
influence of chronic pain on older patients’ difficulty with recommended self-management
activities. The Gerontologist, 47(1), 61-68.
Kristjánsdóttir, Ó. B., Fors, E. A., Eide, E., Finset, A., Stensrud, T. L., van Dulmen, S., et al.
(2013). A smartphone-based intervention with diaries and therapist-feedback to reduce
catastrophizing and increase functioning in women with chronic widespread pain:
Randomized controlled trial. Journal of Medical Internet Research, 15(1), e5.
Kroenke, K., Wu, J., Bair, M. J., Krebs, E. E., Damush, T. M & Tu, W. (2011). Reciprocal
relationship between pain and depression: A 12-month longitudinal analysis in primary
care, The Journal of Pain, 12(9), 964-973.
Kroenke, K., Outcalt, S., Krebs, E., Bair, M. J., Wu, J., Chumbler, N., et al. (2013).
Association between anxiety, health-related quality of life and functional impairment in
primary care patients with chronic pain. General Hospital Psychiatry, 35(4), 359-365.
Lamé, I. E., Peters, M. L., Vlaeyen, J. W. S., Kleef, M. V & Patijn, J. (2005). Quality of life
in chronic pain is more associated with beliefs about pain, than with pain intensity.
European Journal of Pain, 9(1), 15-24.
Law, G. U., Tolgyesi, C. S & Howard, R. A. (2014). Illness beliefs and self-management in
children and young people with chronic illness: A systematic review. Health Psychology
Review, 8(3), 362-380.
![Page 68: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/68.jpg)
54
Leistad, R. B., Nilsen, K. B., Stovner, L. J., Westgaard, R. H., Rø, M & Sand,T. (2008).
Similarities in stress physiology among patients with chronic pain and headache disorders:
evidence for a common pathophysiology mechanism? The Journal of Headache and pain,
9(3), 165-175.
Lethem, J., Slade, P. D., Troup, J. D & Bentley, G. (1983). Outline of a fear-avoidance model
of exaggerated pain perception-I. Behaviour Research and Therapy, 21(4), 401-408.
Linton, S. J & Shaw, W. S (2011) Impact of psychological factors in the experience of pain.
Physical Therapy, 91(5), 700-711.
Lipton, R. B. (2009). Tracing transformation: Chronic migraine classification, progression,
and epidemiology. Neurology, 72(5), S3-S7.
Loeser, J. D. (1982). Concepts of pain. In J. Syanton-Hicks & R. Boaz (Eds.), Chronic low
back pain (pp.109—142). New York: Raven Press.
Loeser, J. D & Treede, R. (2008). The Kyoto protocol of IASP basic pain terminology. Pain,
137(3), 473-477.
Lohnberg, J. A & Altmaier, E. M. (2013). A review of psychosocial factors in complex
regional pain syndrome. Journal of Clinical Psychology in Medical Settings, 20(2), 247-
254.
Louw, A., Diener, I., Butler, D. S & Puentedura, E. J. (2011). The effect of neuroscience
education on pain, disability, anxiety, and stress in chronic musculoskeletal pain. Archives
of Physical Medicine and Rehabilitation, 92(12), 2041-2056.
Luk, K. D., Wan, T. W., Wong, Y. W., Cheung, K. M., Chan, K. Y., Cheng, A. C., et al.
(2010). A multidisciplinary rehabilitation programme for patients with chronic low back
pain: A prospective study. Journal of Orthopaedic Surgery, 18(2), 131-138.
Manchikanti, L., Atluri, S., Trescot, A & Giordano, J. (2008). Monitoring opioid adherence
in chronic pain patients: Tools, techniques and utility. Pain Physician, 11(1), 1-26.
![Page 69: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/69.jpg)
55
Mannion, A. F., Helbling, D., Pulkovski, N & Sprott, H. (2009). Spinal segmental
stabilisation exercises for chronic low back pain: Programme adherence and its influence
on clinical outcome. European Spine Journal, 18, 1881-1891.
Pereira, L. S., Sherrington, C., Ferreira, M. L., Tiedemann, A., Ferreira, P. H., Blyth, F. M., et
al. (2014). Self-reported chronic pain is associated with physical performance in older
people leaving aged care rehabilitation. Clinical Interventions in Aging, 9, 259-265.
McBeth, J & Jones, K. (2007). Epidemiology of chronic musculoskeletal pain. Best Practice
& Research Clinical Rheumatology, 21(3), 403-425.
McWilliams, L. A., Edmonton, A. B., Higgins, K. S., Dick, B. D & Verrier, M. J. (2014). A
longitudinal investigation of pain-related social support preferences in a chronic pain
treatment sample. The Clinical Journal of Pain, 30(8), 672-678.
Menezes Costa, L. C., Maher, C. G., McAuley, J. H., Hancock, M. J & Smeets, R. J. E. M.
(2011). Self-efficacy is more important than fear of movement in mediating the
relationship between pain and disability in chronic low back pain. European Journal of
Pain, 15(2), 213-219.
Merskey, H & Bogduk, N. (1994). Classification of chronic pain (2nd Ed, pg.1). Seattle:
IASP Press.
Meziat Filho, N. (2016). Changing beliefs for changing movement and pain: Classification-
based cognitive functional therapy (CB-CFT) for chronic non-specific low back pain.
Manual Therapy, 21, 303-306.
Miró, E., Martinez, M. P., Sánchez, A. I., Prados, G & Medina, A. (2011). When is pain
related to emotional distress and daily functioning in fibromyalgia syndrome? The
mediating roles of self-efficacy and sleep quality. British Journal of Health Psychology,
16(4), 799-814.
![Page 70: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/70.jpg)
56
Mohammadi, S., Dehghani, M., Sanderman, R & Hagdoorn, M. (2017). The role of pain
behaviour and family caregiver responses in the link between pain catastrophising and
pain intensity: A moderated mediation model. Psychology & Health, 32(4), 422-438.
Molton, I. R., Stoelb, B. L., Jensen, M. P., Ehde, D. M., Raichle, K. A & Cardenas, D. D.
(2009). Psychosocial factors and adjustment to chronic pain in spinal cord injury:
Replication and cross-validation. Journal of Rehabilitation Research and Development,
46(1), 31-42.
Nahin, R. L. (2015). Estimates of pain prevalence and severity in adults: United States, 2012.
The Journal of Pain, 16(8), 769-780.
Natoli, J. L., Manack, A., Dean, B., Butler, Q., Turkel, C. C., Stovner, L., et al. (2009).
Global prevalence of chronic migraine: a systematic review. Cephalagia, 30(5), 599-609.
Neville, A., Peleg, R., Singer, Y, Sherf, M & Shvartzman, P. (2008). Chronic pain: A
population-based study. Israel Medical Association Journal, 10(10), 676-680.
Nicholas, M. K., Asghari, A., Corbett, M., Smeets, R. J. E. M., Wood, B. M., Overton, S., et
al. (2012). Is adherence to pain self-management strategies associated with improved pain,
depression and disability in those with disabling chronic pain? European Journal of Pain,
16(1), 93-104.
Nicholas, M. K., Linton, S. J., Watson, P. J., Main, C. J & the “Decade of the Flags” Working
Group. (2011). Early identification and management of psychological risk factors (“yellow
flags”) in patients with low back pain: A reappraisal. Journal of the American Physical
Therapy Association, 91(5), 737-753.
Nicklas, L. B., Dunbar, M & Wild, M. (2010). Adherence to pharmacological treatment of
non-malignant chronic pain: The role of illness perceptions and medication beliefs.
Psychology & Health, 25(5), 601-615.
![Page 71: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/71.jpg)
57
Norman, S. B., Stein, M. B., Dimsdale, J. E & Hoyt, D. B. (2007). Pain in the aftermath of
trauma is a risk factor for post-traumatic stress disorder. Psychological Medicine, 38(4),
533-542.
Oslund, S., Robinson, R. C., Clark, T. C., Garofalo, J. P., Behnk, P., Walker,B., et al. (2009).
Long-term effectiveness of a comprehensive pain management program: strengthening the
case for interdisciplinary care. Proceedings (Baylor University Medical Centre), 22(3),
211-214.
Otis, J. D., Keane, T. M & Kerns, R. D. (2003). An examination of the relationship between
chronic pain and post-traumatic stress disorder. Journal of Rehabilitation Research and
Development, 40(5), 397-406.
Palazzo, C., Klinger, E., Dorner, V., Kadri, A., Thierry, O., Boumenir, Y., et al. (2016).
Barriers to home-based exercise program adherence with chronic low back pain: Patient
expectations regarding new technologies. Annals of Physical Rehabilitation Medicine,
59(2), 107-113.
Parr, J. J., Borsa, P. A., Filingim, R. B., Tillman, M. D., Manini, T. M., Gregory, C. M., et al.
(2012). Pain-related fear and catastrophizing predict pain intensity and disability
independently using an induced muscle injury model. The Journal of Pain, 13(4), 370-
378.
Peres, M. F. P & Lucchetti, G. (2010). Coping strategies in chronic pain. Current Pain and
Headache Reports, 14(5), 331-338.
Pérez-Fernández, M., Lerma-Lara, S., Ferrer-Peňa, R., Gil-Martinez, A., López-de-Uralde-
Villanueva, I., Paris-Alemany, A., et al. (2015). Fear and difficulty perceived when
visualizing therapeutic exercise in patients with chronic low back pain: A cross-sectional
study. Journal of Exercise Rehabilitation, 11(6), 345-355.
![Page 72: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/72.jpg)
58
Phifer, J., Skelton, K., Weiss, T., Schwartz, A. C., Wingo, A., Gillespie, C. F., et al. (2011).
Pain symptomatology and pain medication use in civilian PTSD. Pain, 152(10), 2233-
2240.
Plesh, O., Adams, S. H & Gansky, S. A. (2011). Temporomandibular joint and muscle
disorder-type pain and comorbid pains in a national US sample. Journal of Orofacial Pain,
25(3), 190-198.
Pompili, M., Innamorati, M., Serafini, G., Gonda, X., Campi, S., Rapinesi, C.,et al. (2012).
How does subjective experience of pain relate to psychopathology among psychiatric
patients? General Hospital Psychiatry, 34(5), 34-540.
Pompili, M., Serafini, G., Di Cosimo, D., Dominici, G., Innamorati, M., Lester, D., et al.
(2010). Psychiatric comorbidity and suicide risk in patients with chronic migraine.
Neuropsychiatric Disorder Treatment, 6(1), 81-91.
Rathleff, M. S., Roos, E. M., Olesen, J. L & Rasmussen, S. (2013). High prevalence of daily
and multi-site pain – a cross-sectional population-based study among 3000 Danish
adolescents. BMC Pediatrics, 13(191), 1-10.
Richardson, E. J., Ness, T. J., Doleys, D. M., Baňos, J. H., Cianfrini, L & Richards, J. S.
(2009). Depressive symptoms and pain evaluations among persons with chronic pain:
Catastrophizing, but not pain acceptance, shows significant effects. Pain, 147(1-3), 147-
152.
Roditi, D & Robinson, M. E. (2011). The role of psychological interventions in the
management of patients with chronic pain. Psychology Research and Behavior
Management, 4, 41-49.
Roh, Y. H., Lee, B. K., Noh, J. H., Oh, J. H., Gong, H. S & Baek, G. H. (2012). Effect of
depressive symptoms on perceived disability in patients with chronic shoulder pain.
Archives of Orthopaedic and Trauma Surgery, 132(9), 1251-1257.
![Page 73: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/73.jpg)
59
Sansone, R. A & Sansone, L. A. (2012). Chronic pain syndromes and borderline personality.
Innovations in Clinical Neuroscience, 9(1), 10-14.
Schopflocher, D., Taenzer, P & Jovey, R. (2011). The prevalence of chronic pain in Canada.
Pain Research and Management, 16(6), 445-450.
Schulz, S., Brenk-Franz, K., Kratz, A., Petersen, J. J., Riedel-Heller, S. G., Schäfer, I., et al.
(2015). Self-efficacy in multimorbid elderly patients with osteoarthritis in primary care –
influence on pain-related disability. Clinical Rheumatology, 34(10), 1761-1767.
Shaw, W. S., Main, C. J & Johnston, V. (2011). Addressing occupational factors in the
management of low back pain: Implications for physical therapist practice. Journal of the
American Physical Therapy Association, 91(5), 777-789.
Skidmore, J. R., Koenig, A. L., Dyson, S. J., Kupper, A. E., Garner, M. J & Keller, C. J.
(2015). Pain self-efficacy mediates the relationship between depressive symptoms and
pain severity. The Clinical Journal of Pain, 31(2), 137-144.
Solidaki, E., Chatzi, L., Bitsios, P., Markatzi, I., Plana, E., Castro, F., et al. (2010). Work
related and psychological determinants of multi-site musculoskeletal pain. Scandinavian
Journal of Work an Environmental Health, 36(1), 54-61.
Sperber, A. D & Drossman, D. A. (2011). Review article: the functional abdominal pain
syndrome. Alimentary Pharmacology and Therapeutics, 33(5), 514-524.
Stanos, S. (2012). Focused review of interdisciplinary pain rehabilitation programs for
chronic pain management. Current Pain and Headache Reports, 16(2), 147-152.
Steiner, A. S., Sartori, M., Leal, S., Kupper, D., Gallice, J. P., Rentsch, D., et al. (2013).
Added value of an intensive multidisciplinary functional rehabilitation programme for
chronic low back pain patients. Swiss Medical Weekly, 143, w13763.
![Page 74: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/74.jpg)
60
Stern, A., Sánchez-Magro, I & Rull, M. (2011). Chronic noncancer pain intensity is inversely
related to analgesic adherence in pain clinics. Journal of Medical Economics, 14(5), 568-
575.
Tolba, R., Shroll, J., Kanu, A & Rizk, M. K. (2015). The epidemiology of chronic abdominal
pain. In Kapural, L. (Ed.). Chronic Abdominal Pain: An Evidence-Based, Comprehensive
Guide to Clinical Management, (pp.13-24). New York: Springer Science & Business
Media.
Turk, D. C., Fillingim, R. B., Ohrbach, R & Patel, K. V. (2016). Assessment of psychosocial
and functional impact of chronic pain. The Journal of Pain, 17(9), T21-49.
Turk, D. C.,Wilson, H. D & Cahana, A. (2011). Treatment of chronic non-cancer pain. The
Lancet, 377(9784), 2226-2235.
Jensen, T. S., Baron, R., Haanpää, M., Kalso, E., Loeser, J. D., Rice, A. S. C., et al. (2011). A
new definition of neuropathic pain. Pain, 152(1), 2204-2205.
Tunks, E. R., Crook, J & Weir, R. (2008). Epidemiology of chronic pain with psychological
comorbidity: prevalence, risk, course, and prognosis. The Canadian Journal of Psychiatry,
53(4), 224-234.
van Hecke, O., Torrance, N & Smith, B. H. (2013). Chronic pain epidemiology and its
clinical relevance. British Journal of Anaesthesia, 111(1), 13-18.
Verkerk, K., Luijsterburg, P. A., Heymans, M. W., Ronchetti, I., Pool-Goudzwaard, A. L.,
Miedema, H. S., et al. (2013). Prognosis and course of disability in patients with chronic
nonspecific low back pain: a 5- and 12-month follow-up cohort study. Physical Therapy,
93(12), 1603-1614.
Verkerk, K., Luijsterburg, P. A., Ronchetti, I., Pool-Goudzwaard, A. L., Heymans, M. W.,
Ronchetti, I., Miedema, H. S., et al. (2015). Prognosis and course of work-participation in
![Page 75: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/75.jpg)
61
patients with chronic non-specific low back pain: a 12-month follow-up cohort study.
Journal of Rehabilitation Medicine, 47(9), 854-859.
Vlaeyen, J. W. S & Linton, S. J. (2000). Fear-avoidance and its consequences in chronic
musculoskeletal pain: A state of the art. Pain, 85(3), 317-332.
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., et al. (2012).
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-
2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet,
380(9859), 2163-2196.
Wertli, M. M., Rasmussen-Bar, E., Held, U., Weiser, S., Bachmann, L. M & Brunner, F.
(2014). Fear-avoidance beliefs – a moderator of treatment efficacy in patients with low
back pain: a systematic review, The Spine Journal, 14(11), 2658-2678.
Wicksell, R. K., Lekander, M., Sorjonen, K & Olsson, G. L. (2010). The psychological
inflexibility in pain scale (PIPS) – Statistical properties and model fit of an instrument to
assess change processes in pain related disability. European Journal of Pain, 14(7),
771.e1-771.e14.
Wideman, T. H & Sullivan, M. J. L. (2011). Differential predictors of thelong-term levels of
pain intensity, work disability, healthcare use, and medication use in a sample of workers’
compensation claimants. Pain, 152(2), 376-383.
Wong, W. S., Chow, Y. F., Chen, P. P., Wong, S & Fielding, R. (2015). A longitudinal
analysis on pain treatment satisfaction among Chinese patients with chronic pain:
Predictors and association with medical adherence, disability, and quality of life. Quality
of Life Research, 24(9), 2087-2097.
World Health Organisation. (2003). Adherence to Long-Term Therapies: Evidence for
Action, Geneva: WHO.
![Page 76: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/76.jpg)
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Yazdi-Ravandi, S., Taslimi, Z., Jamshidian, N., Saberi, H., Shams, J & Haghparast, A.
(2013). Prediction of quality of life by self-efficacy, pain intensity and pain duration in
patient with pain disorders. Basic and Clinical Neuroscience, 4(2), 117-124.
Zuccaro, S. M., Velluci, R., Sarzi-Puttini, P., Cherubino, P., Labianca, R & Fornasari, D.
(2012). Barriers to pain management: Focus on opioid therapy. Clinical Drug
Investigation, 32(1), 11-19.
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Chapter 2
Study One: Do pain-related beliefs influence treatment adherence? A systematic review
Emma Thompson1, Jaclyn Broadbent1, Melanie Bertino1,2 and Petra Staiger1
1 School of Psychology, Deakin University, Burwood
2 The Victorian Rehabilitation Centre
This paper was published in The Journal of Clinical Pain (TJCP). TJCP have specific
guidelines for structure, formatting and referencing. This paper was prepared in accordance
with those guidelines.
Article reference: Thompson, E., Broadbent, J., Bertino, M & Staiger, P. (2016). Do pain-
related beliefs influence treatment adherence? A systematic review. The Journal of Clinical
Pain, 32(2), 164-178.
Impact factor: 2.703
Number of citations: 10
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Abstract
Objectives: To understand how pain-related cognitions predict and influence treatment
retention and adherence during and after a multidisciplinary rehabilitation program.
Methods: Electronic databases including Medline, CINAHL, PsycINFO, Academic Search
Complete, and Scopus were used to search three combinations of keywords: chronic pain,
beliefs, and treatment adherence.
Results: The search strategy yielded 591 results, with an additional 12 studies identified
through reference screening. 81 full-text papers were assessed for eligibility and 10 papers
met the inclusion and exclusion criteria for this review. The pain-related beliefs that have
been measured in relation to treatment adherence include: pain-specific self-efficacy,
perceived disability, catastrophizing, control beliefs, fear-avoidance beliefs, perceived
benefits and barriers, as well as other less commonly measured beliefs. The most common
pain-related belief investigated in relation to treatment adherence was pain-related self-
efficacy. Findings for the pain-related beliefs investigated among the studies were mixed.
Collectively, all of the aforementioned pain-related beliefs, excluding control beliefs, were
found to influence treatment adherence behaviours.
Discussion: The findings suggest that treatment adherence is determined by a combination of
pain-related beliefs either supporting or inhibiting chronic pain patients’ ability to adhere to
treatment recommendations over time. In the studies reviewed, self-efficacy appears to be the
most commonly researched predictor of treatment adherence, its effects also influencing other
pain-related beliefs. More refined and standardised methodologies, consistent descriptions of
pain-related beliefs and methods of measurement will improve our understanding of
adherence behaviours.
Keywords: chronic pain; beliefs; treatment adherence
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2.1 Introduction
There has been a growing recognition that the degree of chronic pain is influenced by
the beliefs, attitudes and expectations of individuals [1]. Pain-related cognitions that have
been found to impede recovery include low self-efficacy [2], catastrophizing [3], fear-
avoidance beliefs [4], locus of control beliefs [5], and perceived disability [6], among others.
These pain-related cognitions or beliefs are consistently found to predict negative outcomes
among patients suffering from chronic pain. For example, pain patients who possess low
pain-specific self-efficacy beliefs (i.e., reduced confidence in one’s ability to perform specific
tasks such as coping with pain) have been found to experience worsened pain outcomes
compared to chronic pain patients with high self-efficacy beliefs [1,2,4]. It is important to
recognise and understand the implications of unhelpful pain-related cognitions in order to
tailor more effective treatment interventions and thus, improve chronic pain outcomes.
Despite the high prevalence and negative outcomes often associated with chronic pain, there
is limited research examining the influence of pain-related cognitions on treatment adherence.
The World Health Organisation (WHO) defines adherence as ‘the extent to which a person’s
behaviour (i.e., taking medication, following a diet or exercise plan, and/or executing lifestyle
change), corresponds with recommendations from a health care professional (HCP)’ [7].
Following this definition, measurement of adherence varies depending on the nature of the
treatment recommended by the HCP (e.g., attendance to supervised sessions and/or assessment of
unsupervised home-based activities). This has led to some criticism regarding the construct of
adherence as inherently elusive. Despite this, adherence to treatment recommendations is
essential to reduce disability outcomes associated with chronic pain such as restricted
mobility [8], reduced working capacity [9] and co-morbid psycho-pathology [10]. However,
treatment recommendations are not always adhered to after the completion of an intervention,
and patients may experience exacerbated pain symptoms as a result [11]. Non-adherence not
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only impairs patient’s quality of life, it contributes to the growing prevalence and economic
burden on the public health system [12].
There is a literature examining the relationships between treatment adherence and chronic
pain [13,14], as well as cognitions associated with the experience of chronic pain [2-6]
however, there is very little research investigating the interrelationships between chronic
pain, cognitions, and treatment adherence concurrently. In addition, a large majority of the
chronic pain literature that includes information on treatment adherence focuses on
examining adherence to medical interventions (e.g., adherence to clinical guidelines for
opioid therapy and subsequent substance misuse) [15-16]. However, a growing body of
literature suggest that multidisciplinary intervention (i.e., a combination of physiotherapy or
exercise physiology, psychology, occupational therapy, and hydrotherapy components) is
often required in order to effectively manage chronic pain symptoms [17,18,19] and is largely
becoming ‘best practice’ for the treatment of chronic pain [19-21]. Therefore, examination of
the relationships that exist among pain-related cognitions and adherence to multidisciplinary
treatment is important to identify the barriers to effective intervention and inform best
practice for chronic pain management. The aim of this paper was to conduct a systematic
review to identify empirical studies which have examined the associations between
cognitions and treatment adherence among chronic pain patients receiving multidisciplinary
intervention. The specific questions addressed in this review were as follows:
1. Which pain-related cognitions predict increased treatment adherence during a
multidisciplinary program?
2. To what extent do these pain-related cognitions influence adherence to treatment
recommendations post treatment?
This review was based on the guidelines set out by the PRISMA statement for
systematic reviews [22].
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2.2 Method
2.2.1 Search strategy
The search protocol for this review was developed using widely recommended methods for
systematic reviews for observational studies [23]. Electronic databases including Medline,
CINAHL, PsycINFO, Academic Search Complete, and Scopus were used. The search term
combination for electronic databases contained the words chronic pain, beliefs, and treatment
adherence (see Figure 3). Based on published advice, relevant MeSH terms, subject headings,
text words, and word variants were used [23]. We also manually searched the bibliographies
of all relevant articles to identify papers not captured by electronic databases.
Search 1:
“chronic pain” or “persistent pain” or “recurrent pain”
AND
“treatment adherence” or “adherence to treatment recommendation*” or adherence or
“adherence behavio?r” or “adherence enhancement” or “pain treatment adherence” or
"guideline adherence" or compliance or “patient compliance” or “non?compliance” or
“patient participation” or “patient dropout*” or “patient refusal of treatment” or “treatment
engagement” or “treatment concordance” or “treatment disengagement” or “treatment
refusal” or “treatment barrier*” or “treatment dropout*” or “treatment compliance”
Limiters: adults, peer-reviewed, 2000-2014
188 articles found
Search 2:
“chronic pain” or “persistent pain” or “recurrent pain”
AND
belief* or “health belief*” or perceive* or perception* or attitude* or “attitude to health”
AND
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“treatment adherence” or “adherence to treatment recommendation*” or adherence or
“adherence behavio?r” or “adherence enhancement” or “pain treatment adherence” or
"guideline adherence" or compliance or “patient compliance” or “non?compliance” or
“patient participation” or “patient dropout*” or “patient refusal of treatment” or “treatment
engagement” or “treatment concordance” or “treatment disengagement” or “treatment
refusal” or “treatment barrier*” or “treatment dropout*” or “treatment compliance”
Limiters: adults, peer-reviewed, 2000-2014
48 articles found
Search 3:
“chronic pain” or “persistent pain” or “recurrent pain”
AND
belief* or “health belief*” or perceive* or perception* or attitude* or “attitude to health” or
or self?efficacy or fear?avoidance or “perceived disability” or catastrophi?ing or “perceived
control” or “recovery expectation*”
AND
“treatment adherence” or “adherence to treatment recommendation*” or adherence or
“adherence behavio?r” or “adherence enhancement” or “pain treatment adherence” or
"guideline adherence" or compliance or “patient compliance” or “non?compliance” or
“patient participation” or “patient dropout*” or “patient refusal of treatment” or “treatment
engagement” or “treatment concordance” or “treatment disengagement” or “treatment
refusal” or “treatment barrier*” or “treatment dropout*” or “treatment compliance”
Limiters: adults, peer-reviewed, 2000-2014
49 articles found
Figure 3. Example of a full search strategy using Medline Complete
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2.2.2 Eligibility criteria
Eligibility criteria included: Participants had to be adults (18+ years) with chronic pain of
more than three months. In addition, only peer-reviewed studies published in the English
language and between the years 2000 and 2014 were included in the review.
As treatment adherence was the variable of interest in the review, all studies without
adherence data were excluded, as were studies that did not directly compare pain-related
beliefs and treatment adherence outcomes. Also, given the psycho-social focus of the review,
the exclusion criteria also included studies that focused on adherence to a medical approach
or pharmacological treatment.
2.2.3 Selection process
Studies were eligible if they provided information on the association of pain-related beliefs
with treatment adherence. Studies were not included that examined the effect of pain-related
beliefs on chronic pain treatment outcomes (e.g., pain severity, functional outcomes) as this
has previously been examined extensively in the literature. One author (ET) independently
screened the titles and abstracts of identified citations for potential eligibility. Discrepancies
were resolved by consensus (ET, JB, MB) or by a fourth author (PS) if necessary. All authors
then examined the full texts of potential articles to determine eligibility for inclusion in the
review.
2.2.4 Data abstraction
Data from the studies were collated and synthesised manually, and placed into tables to allow
for the comparison of the study aims, pain-related beliefs investigated, treatment adherence
outcomes, sample and methodology, outcomes, measures, and findings (see Table 1). Table 2
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provides a list of the 70 excluded studies and reasons for exclusion in reverse chronological
order. The table categorises 9 reasons for exclusion.
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Table 1. Systematic review table (alphabetical order according to first author)
First author, country
Research aims/questions
Pain-related beliefs
Sample, mean age years
(SD), design/method
Outcome measures
Measures used
Findings
Coppack et al., 2012
UK
Aim:
To examine the effects of
goal setting intervention on
self- efficacy, treatment
efficacy, adherence, and
treatment outcome in
patients undergoing a lower
back pain rehabilitation
programme
Self-efficacy Sample size: 48
Design method: prospective
and longitudinal
Participants: chronic low
back pain patients referred to
the early spines treatment
group at the UK Defence
Medical Rehabilitation
Centre (DMRC) for
inpatient rehabilitation
Mean age: 32.9 (SD = 7.9)
All groups
completed the
standard exercise
program
Experimental group
(goal setting and
exercise therapy) –
also completed a
goal setting
performance profile
assessment: Initial
assessment (T1),
day 6 (T2), and day
11 (T3)
Control group 1
(C1; therapist-led
exercise therapy)
Sports Injury Rehabilitation Beliefs
Survey (SIRBS)
Sport Injury Rehabilitation Adherence
Scale (SIRAS) – a mean value was
calculated for the SIRAS across the
nine appointments, to yield an overall
adherence score
Behavioural Regulation in Exercise
Questionnaire (BREQ-2) - used as a
covariate to account for the possible
confound of motives for exercise
participation on adherence
Significant differences were found among self-efficacy
and adherence scores over time, regardless of group
allocation
The experimental group exhibited significantly higher
scores of goal setting and self-efficacy when compared
to both control groups, indicating a relationship
between self-efficacy and adherence
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Control group 2
(C2; non-therapist-
led exercise
therapy)
Curran et al., 2009
UK
Aim:
To assess determinants of
adherence to treatment
recommendations, and to
examine the extent to which
cognitive and behavioural
adherence predicts better
outcome of cognitive
behavioural treatment for
persistent pain
Self-efficacy
Catastrophising
Sample size: 2,345
Design method: longitudinal
Participants: pain patients
from the UK who attended a
two or four week (9-day or
16-day) inpatient pain
management programme
Mean age: 45 (SD = 12)
Battery of
questionnaires
completed on 4
occasions over 6 or
8 months
(depending on
programme):
Before the start of
treatment (T1)
On the last day of
treatment (either 2
weeks or 4 weeks;
T2)
One month follow-
up (T3)
Pain Self-Efficacy Questionnaire
(PSEQ)
Pain Catastrophizing Scale
Coping Strategies Questionnaire (CSQ)
Adherence measures using 6 separate
self-report scales (e.g., 1 = stopped
completely, 6 = performed daily):
Exercise Frequency, Stretch
Frequency, Pacing Frequency, Pacing
Occasion, Cognitive Techniques,
Frequency, Cognitive Techniques
Occasion
Adherence variables were correlated with self-efficacy
at T2, but not at T1. Adherence variables were
correlated with self-efficacy and non-catastrophic
thinking at T3
6% of the variance in overall adherence is accounted for
by level of psychological wellbeing post-treatment.
Psychological wellbeing includes self-efficacy and
catastrophizing, depression and coping
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Adherence
measured only at
T3
Dobkin et al., 2005
Canada
Aim:
To examine the variables
that contributes to
maintenance of exercise for
the 3-month critical period
following termination of the
program
Self-efficacy
Disability
Perceived benefits
Perceived barriers
Sample size: 33
Design method: prospective
Participants: female patients
with diagnosed
Fibromyalgia (FM) were
recruited into a randomised
control trial
Mean age: 49.2 (SD = 8.7)
Battery of
questionnaires
completed on 3
occasions over 6
months:
Baseline (T1)
Post-treatment (T2)
3 months follow-up
(T3)
Exercise logs were
completed by
participants at the
end of each exercise
session, each week,
during the
supervised phase of
treatment, and
Fibromyalgia Impact Questionnaire
(FIQ) to assess disability over the past
week
Arthritis Self-Efficacy Scale – 2 of the
3 subscales were used: self-efficacy for
pain management and self-efficacy for
other FM symptoms
Exercise Beliefs Questionnaire - to
assess self-efficacy for exercise,
barriers to exercise, and benefits of
exercise on FM
Exercise logs included: the type of
exercise performed, frequency,
duration, and heart rate
Benefits of exercise during treatment showed increased
adherence over time, even if benefits of exercise at
baseline did not significantly predict adherence
Significantly greater increases in perceived barriers
during treatment predicted significant decreases in post-
treatment aerobic participation, the negative effect of
higher pre- treatment barriers was non-significant
Higher pre-treatment FIQ scores did not predict worse
maintenance. The in- treatment change in FIQ also had
no impact
Self-efficacy was not found to predict treatment
adherence
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during the
unsupervised phase
Dobkin et al., 2010
Canada
Aim:
To identify predictors of
disability and pain 6 months
after the end of a
multimodal FM treatment
program and to determine
whether adherence
influenced outcomes
Self-efficacy
Disability
Sample size: 46
Design method: prospective
Participants: widespread
pain patients in an
established 3 month
multimodal treatment
program for FM at the
Jewish Rehabilitation
Hospital (JRH) in Montreal,
Canada
Mean age: 53.6 (SD = 14.5)
Psychosocial
factors were
measured at
baseline (T1), at the
end of treatment (3
months; T2), and 6
months follow-up
(T3)
Adherence factors
were measured
during treatment at
the end of each
month, at the end of
treatment (3
months; T2), and 6
months follow-up
(T3)
Arthritis Self-Efficacy Scale - 2 of the
3 subscales: (1) self- efficacy for pain
management, and (2) self-efficacy for
other (FM) symptoms
The General Adherence Scale
(Sherbourne et al., 1992) – 5 questions
about level of difficulty and frequency
in following treatment
recommendations
Specific Adherence Scale - developed
by the authors, based on the Barriers to
Treatment Adherence Questionnaire.
Developed to measure adherence to
therapists' suggestions and various
recommendations of the program
Change in self-efficacy for pain from baseline to the
end of treatment was found to be significantly
associated with general adherence scores during
treatment
Patients whose average general adherence during
treatment increased by 1 SD, in turn, decreased their
disability scores by 10.07 SD points more than patients
whose general adherence during treatment was 1 SD
below the mean
Engstrom & Oberg, 2005
Sweden
Locus of control
Perceived threats
Sample size: 353
Design method: prospective
All clinic patients
answer a
questionnaire pre-
Pre therapy questionnaire: 8 statements
about health locus of control (not
published)
Health belief variables differed between those with low
or high exercise adherence. Participants’ with low
adherence reported higher Oswestry scores. They also
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Aim:
To describe pain patients
who did not complete their
participation or who
participated infrequently in
treatment based on their
own activity and
responsibility, and to
understand the phenomenon
of adherence from a
behavioural theoretical
perspective
Perceived consequences
Perceived barriers
Perceived benefits
Expectation of
treatment
Participants: pain patients
recruited from a primary
health care PT clinic in a
middle-sized town in
southern Sweden.
Mean age: 40
treatment (T1), post
treatment (6-8
weeks; T2), and 6
and 12 months after
the start of
treatment (T3)
Questions concerning health beliefs
were repeated at all time-points
Measures of perceived threats: pain
intensity (VAS), use of pain killers, and
pain frequency
Measures of perceived consequences:
Oswestry Low Back Pain Disability
Questionnaire, duration of pain,
duration of sick leave and distribution
of pain
Measures of perceived benefits and
perceived barriers: participants’
experiences from earlier treatments,
expectations of treatment outcome
Adherence measures – completers and
non-completers of the treatment
program. Completers also analysed for
high, medium, or low exercise
frequency.
rated lower expectations of treatment. They were
mainly younger and mainly women
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Glombiewski et al., 2010
Germany
Aim:
To describe time of and
reasons for dropout from
Cognitive Behavior
Therapy (CBT) for chronic
back pain and to examine
the relevance of patients'
attitudes toward treatment
associated with dropout
from CBT for chronic back
pain
Attitude toward
treatment
Pain disability
Sample size: 128
Design method: prospective
Participants:
musculoskeletal pain
patients recruited over a 3
year period directly in two
outpatient anaesthesiology
centres and general
practitioner’s offices, or self-
referred through media
publicity
Mean age: completers: 50
(SD = 11.32), dropouts: 43.3
(SD = 12.25)
Measures were
taken at pre-
treatment (T1) and
additionally 4
months before
treatment for the
wait list control
group, after session
5 (T2), after session
17 (T3), at post-
treatment (T4), and
at 6 months follow-
up (T5)
Attribution of Chronic Pain Patients
(KAUKON) Questionnaire
5 Likert-type ratings measuring
attitudes toward psychological
treatment
Adherence measure - Dropout
questionnaire which assessed the
reasons for dropping out of treatment
Those who did not complete the
dropout questionnaire were called by
phone and interviewed about dropout
reasons
Treatment adherers and treatment non-adherers did not
differ on their attitude toward treatment, nor did they
differ regarding psychological and medical control and
causal attributions
Heapy et al., 2005
USA
Aim:
To examine the relative
ability of self- efficacy
Self-efficacy Sample size: 78
Design method: prospective
Participants: chronic pain
patients recruited from a
Self-efficacy was
measured at
baseline (T1)
Adherence to the
goals were assessed
The patient’s completed a rating of
adherence on a 0 (not at all
accomplished) to 10 (completely
accomplished) scale
Self-efficacy at baseline was not found to be
significantly associated with adherence
Treatment adherence was not a mediator between self-
efficacy and goal accomplishment
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ratings to predict adherence
and goal accomplishment.
To examine the hypothesis
that adherence mediates the
relationship between self-
efficacy and post- treatment
outcomes
(Veteran’s Affairs)VA
primary care clinic
Mean age: 54.1 (SD = 10.9)
at each treatment
session (T2)
A patient goal expectancy rating was
used to assess goal-specific self-
efficacy
Mannion et al., 2009
Switzerland
Aim:
To evaluate the influence of
various cognitive factors
and beliefs on adherence to
a programme of therapeutic
“spinal segmental
stabilisation” exercises
Self-efficacy
Locus of control
Fear-avoidance beliefs
Catastrophising
Sample size: 32
Design method: prospective
Participants: chronic low
back pain patients recruited
from the departments of
rheumatology, orthopaedics,
and neurology of local
participating hospitals (one
university hospital, two
foundation hospitals, and a
local GP practice).
Mean age: 44.0 (SD = 12.3)
Before (T1) and
after (T3) treatment
patients completed
a battery of
questionnaires
Adherence diaries
were completed by
patients each week
(T2)
The remaining
adherence measures
were assessed by
the clinician after
each session (T2)
Exercise Self-Efficacy Questionnaire
Multidimensional Health Locus of
Control (MHLC) Questionnaire
Fear-avoidance beliefs Questionnaire
Pain catastrophising Questionnaire
Self-report daily exercise diary to
document the frequency of exercises
performed at home.
Sports Injury Rehabilitation Adherence
Scale (SIRAS)
Exercise self-efficacy at baseline showed low, but
significant, correlation with adherence
None of the scores for the different domains of the
MHLC (internal, powerful others, fate) showed any
significant correlation with the MAI scores
None of the psychological questionnaire scores at
baseline (fear-avoidance beliefs, catastrophising) were
significantly correlated with adherence (MAI scores)
Forward stepwise multiple linear regression analysis of
gender and self-efficacy scores on the transformed MAI
adherence scores revealed that both variables were
significant predictors, together accounting for
approximately 32% of variance in MAI and self-
efficacy
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Multidimensional Adherence Index
(MAI)
Nicholas et al., 2012
Australia
Aim :
To test adherence to self-
management strategies,
using unhelpful beliefs
about pain at baseline as
moderators of treatment
outcome
Self-efficacy
Catastrophising
Fear-avoidance beliefs
Sample size: 567
Design method: prospective
Participants: pain patients
admitted to a 3-week out-
patient pain management
program (ADAPT) at the
Pain Management and
Research Centre, Royal
North Shore Hospital,
Sydney, Australia, from
2004 to early 2008
Mean age: 44 (SD = 11.8)
Questionnaires
were completed pre
(T1) and post
treatment (T2)
Clinicians
monitored patient
adherence on a
daily basis, and
categorised overall
adherence at the
end of the program
Pain Self-Efficacy Questionnaire
(PSEQ)
Catastrophising Scale of the Pain
Response Self- Statements Scale
(PRSS)
Tampa Scale for Kinesiophobia (TSK)
Patient's completed daily worksheets
which recorded their practice of each
strategy. The treatment team later
examined each worksheet and
summarised each patient's adherence
(using a 0-2 scale, where 0=’not using
the strategy at all’, 1=’using it
inconsistently’, and 2=’using it
consistently’) for each recommendation
Higher degrees of adherence to the strategies were
predictive of greater pre-post treatment changes in the
three cognitive process variables – catastrophizing ,
fear-avoidance , and pain self- efficacy beliefs
Robinson et al., 2004
USA
Perceived control of
managing pain
Sample size: 180
Design method: prospective
The timing and
duration of
treatments was
Pre-treatment:
There was no significant difference between
participants' and HCPs' mean ratings of perceived
health benefits from complying with treatment
recommendations. Perceived benefits and interference
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Aim:
To explore the variables
associated with adherence
to pain rehabilitation
recommendations from two
perspectives: the patient and
the provider
Perceived control of
treatment compliance
Perceived benefits
Perceived interference
Participants: pain patients
recruited from 2 pain clinics
at a large South-Eastern
University Medical Centre.
Mean age: 50.12 (SD =
12.59)
tailored to the
individual
Patients completed
pre-treatment
measures at the
initial assessment
(T1)
Patients completed
post-treatment
measures at the
follow-up
assessment (T2)
Pain-Anxiety Symptoms Scale (PASS)
to evaluate fear and anxiety related to
pain (e.g., avoidance behaviours)
Post-treatment:
Participant Compliance Reporting
Scale (PCRS), developed by the
authors, assessing level of adherence to
treatment recommendations and the
perceived impact that adherence or
non-adherence had on overall levels of
improvement
Health Professional Compliance
Evaluation (HPCE), developed by the
authors. Similar in content and rating
to the PCRS, assessing practitioner-
report of participant adherence
Participant Pain Reporting Scale
(PPRS) to measure psychosocial
predictors of pain
showed a moderate and positive relationship for
participants’ ratings of adherence
No relationship was evident between perceived
compliance, psychological recommendations, benefit or
perceived interference
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Table 2. List of excluded studies and reasons for exclusion in reverse chronological order
No. Authors Reason
1 Crandall et al. Phys Ther 2013;93:17-21. Review paper
2 Licciardone et al. Ann Fam Med 2013;11:122-129. No beliefs and TA
3 Mertens et al. Trials 2013;14:1-14. Feasibility paper
4 Schauer & Hoenig. Tech Orthop 2013;28:98-102. Descriptive paper
5 Anderson et al. Qual Prim Care 2012;20:421-433. No beliefs and TA
6 Bennell et al. BMC Musculoskelet Disord 2012;13:1-17. Feasibility paper
7 Budge et al. J Prim Health Care 2012;4:306-312. Qualitative study
8 Hicks et al. Clin J Pain 2012;28:195-203. No beliefs and TA
9 Hunter et al. Clin J Pain 2012;28:259-267. No beliefs and TA
10 Lakke et al. Arch Phys Med Rehabil 2012;93:446-457. Review paper
11 Lassen et al. Schmerz 2012;26:402-409. Not in English
12 Lonsdale et al. BMC Musculoskelet Disord 2012;13:1-15. Feasibility paper
13 Salo et al. Disabil Rehabil 2012;34:1971-1977. No beliefs and TA
14 Sullivan & Simon. TBM 2012;2:149-158. No beliefs and TA
15 Tse et al. J Clin Nurs 2012;22:1843-1856. No beliefs and TA
16 Bearne et al. Musculoskeletal Care 2011;9:160-168. No beliefs and TA
17 Langley. Curr Med Res Opin 2011;27:463-480. No beliefs and TA
18 Langley et al. J Med Econ 2011;14:367-380. No beliefs and TA
19 Huge et al. Schmerz 2010;24:459-467. Not in English
20 Huis in ‘t Veld et al. J Telemed Telecare 2010;16:322-328. No beliefs and TA
21 McDonough et al. BMC Musculoskelet Disord 2010;11:1-8. Feasibility paper
22 Nicklas. Psychol Health 2010;25:601-615. Pharmacological focus
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23 Sokunbi et al. Man Ther 2010;15:179-184. No beliefs and TA
24 Bair et al. Pain Med 2009;10:1280-1290. Qualitative study
25 Escolar-Reina et al. Arch Phys Med Rehabil 2009;90:1734-
1739.
No beliefs and TA
26 Medina-Mirapeix et al. J Rehabil Med 2009;41:347-352. Qualitative study
27 Salah Frih et al, Ann Phys Rehabil Med 2009;52:485-496. No beliefs and TA
28 Slade & Keating. BMC Musculoskelet Disord 2009;10:1-8. Feasibility paper
29 Allen et al. Nurs Res 2008;57:107-112. No beliefs and TA
30 Brenner et al. Perspect 2008;32:5-11. No beliefs and TA
31 Davis et al. Pain Manage Nurs 2008;9:171-179. No beliefs and TA
32 Häkkinen et al. Clin Rehabil 2008;22:592-600. No beliefs and TA
33 Jensen et al. Intl J Clin Experi Hyp 2008;56:156-169. No beliefs and TA
34 McDonough et al. BMC Musculoskelet Disord 2008; 9:1-
10.
Feasibility paper
35 Molton et al. J Pain 2008;9:606-612. No beliefs and TA
36 Oliveira et al. J Clin Psychol Med Settings 2008;15:338-
343.
Qualitative study
37 Schwarzer et al. Health Psychol 2008;27:54-63. Not purely CP
38 Basler et al. Eur J Pain 2007;11:31-37. No beliefs and TA
39 Krein et al. Gerontologist 2007;47:61-68. Not purely CP
40 Liddle et al. Disabil Rehabil 2007;29:1899-1909. Qualitative study
41 McGowan et al. Br J Health Psychol 2007;12:261-274. Qualitative study
42 Cook & DeGood. Clin J Pain 2006;22:332-345. No beliefs and TA
43 Dobkin et al. Clin J Pain 2006;22:286-294. No beliefs and TA
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44 Mailloux et al. Am J Phys Med Rehabil 2006;85:120-126. No beliefs and TA
45 Mori et al. Mil Med 2006;171:917-923. Not purely CP
46 Morsø et al. BMC Musculoskelet Disord 2006;7:1-5. No beliefs and TA
47 Austrian et al. J Am Geriatr Soc 2005;53:856-861. Qualitative study
48 Hirsh et al. Clin J Pain 2005;21:302-310. No beliefs and TA
49 Lyngcoln et al. J Hand Ther 2005;18:2-8. No beliefs and TA
50 Michalsen et al. J Alt Comp Med 2005;11:601-607. No beliefs and TA
51 Proctor et al. Arch Phys Med Rehabil 2005;86:1509-1515. No beliefs and TA
52 Middleton. Phys Ther Rev 2005;9:153-160. Descriptive paper
53 Bassett. NZ J Physio, 31(2), 60-66. Descriptive paper
54 Broderick et al, 2003, Ann Behav Med 2003;26:139-148. No beliefs and TA
55 Carroll & Whyte. Br J Ther Rehabil 2003;10:53-58. No pre-post measure
56 Iversen et al. Arch Phys Med Rehabil 2003;84:1324-1331. No beliefs and TA
57 Jensen et al. J Pain 2003;4:477-492. Descriptive paper
58 Kolt & McEvoy. Man Ther, 2003;8:110-116. No beliefs and TA
59 Reid et al. Pain Med 2003;4:223-230. No beliefs and TA
60 Stone et al. Pain 2003;104:343-351. No beliefs and TA
61 Stone et al. Control Clin Trials 2003;24:182-199. No beliefs and TA
62 Alexandre et al. Pan Am J Public Health 2002;12:86-94. Not purely CP
63 Cipher et al. J Health Psychol 2002;7:665-673. No beliefs and TA
64 Evers et al. Pain 2002;100:141-153. Pharmacological focus
65 Jamison et al. Pain Med 2002;3:92-101. No beliefs and TA
66 Naylor et al. J Pain 2002;3:429-438. No beliefs and TA
67 Rainville et al. Spine J 2002;2:402-407. No beliefs and TA
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68 Jamison et al. Pain 2001;91:277-285. No beliefs and TA
69 Gibson & Helme. Pain 2000;85:375-383. No pre-post measure
70 Hoodin et al. Headache 2000;40:377-383. No beliefs and TA
2.3 Results
2.3.1 Description of included studies
The search strategy yielded 591 results, with an additional 12 studies identified through
reference screening; 81 full-text papers were assessed for eligibility and 10 papers met the
inclusion and exclusion criteria for this review. Figure 4 outlines the flow diagram of studies
included in this review. Two of the included studies were conducted in Canada, two in the
United States of America, and two in the United Kingdom, and one study each in Australia,
Switzerland, Sweden and Germany.
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84
Figure 4. Flow diagram of studies included in the review
2.3.2 Methodology
Of the 10 studies included in the review, treatment adherence and pain belief data were
Records identified through
database searching
(n = 1,208)
Scr
een
ing
In
clu
ded
E
ligib
ilit
y
Iden
tifi
cati
on
Additional records identified
through other sources
(n = 12)
Records after duplicates removed
(n = 603)
Records screened
(n =603) Records excluded
(n = 590)
Full-text articles
assessed for eligibility
(n = 80)
Full-text articles excluded,
with reasons
(n = 70)
No measure of pain beliefs
and treatment adherence,
n = 41
Pharmacological focus,
n = 2
No pre-post measure, n = 2
Not investigating chronic
pain specifically, n = 4
Non-English, n = 2
Review paper, n = 2
Qualitative paper, n = 7
Feasibility paper, n = 6
Descriptive paper, n = 4
Studies included in
qualitative synthesis and
review (n = 10)
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obtained from participant’s own self-report in seven studies. The remaining three studies
collected data using a combination of self-reported data from participants and data reported
by the patient’s practitioner [24-26]. Data collection varied among the studies included in the
review. Data was collected on-site during the participant’s treatment in five studies [24,26-
28,32], via telephone interview in one study [25], and via mail in one study [29]. The
remaining three studies did not specify their data collection method [30,31,33].
A meta-analysis was not possible given that the studies included here were too
heterogeneous with very little consistency in relation to the collection and measurement of
outcome data.
2.3.3 Outcome measures
Of the 10 studies reviewed, six studies examined chronic pain according to the International
Association for the Study of Pain (IASP; i.e., pain symptoms with duration of greater than
three months) definition [25-27,29-31]. One study examined chronic pain according to the
American College of Rheumatology criteria for Fibromyalgia [28], and three studies had no
definition of chronic pain [24,32,33]. However, as all of the 10 studies confirmed chronic
pain by clinical interview, the latter three studies were considered eligible to be included in
the review.
Of the 10 studies reviewed, five studies assessed adherence to the recommendations
provided among multidisciplinary treatment programs, including a combination of
psychology, physiotherapy, occupational therapy, and hydrotherapy treatment components
[25,27,29,31,32]. One study assessed adherence to psychological recommendations [30]. The
remaining four studies focused on adherence to exercise regimens [24,26,28,33]. Three
studies assessed adherence to specific and standardized treatment recommendations for all
participants [25,27,32]. Four studies tailored the prescribed treatment recommendations (i.e.,
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timing and duration) to the individual and their level of impairment [25-28]. The remaining
five studies did not specify what recommendations were provided to participants for each of
the treatment modalities [24,29-31,33]. Six of the 10 studies measured adherence at multiple
time points including pre-treatment, mid-treatment and post-treatment [24,26-30]. The
remaining four studies assessed changes in adherence only twice, at pre and post treatment
[25,31-33]. Eight of the 10 studies reviewed used multiple regression analysis to examine
pain-related beliefs and treatment adherence. And the remaining two studies used either
ANOVA [33] or ANCOVA [24].
2.3.4 Pain-related beliefs investigated
The most common pain-related belief investigated in relation to treatment adherence was
pain-related self-efficacy, which was examined in 7 out of 10 studies [24,26-29,31,32]. Three
studies examined the effect of perceived disability on treatment adherence [26-30].
Catastrophising was examined by three studies [26-32], control beliefs were also examined
by three studies [25,26,33] and two studies examined the effect of fear-avoidance beliefs
[26,27]. Other pain-related beliefs that were examined to a lesser degree included perceived
threats and perceived consequences [33], perceived interference [25], perceived benefits
[25,28,33], perceived barriers [28,33], expectation of treatment [33] and attitude toward
treatment [25].
2.3.4.1 Self-efficacy Self-efficacy beliefs in people with chronic pain have been assessed both
by reference to confidence in ability to perform specific tasks and to confidence in
performing more generalised constructs like coping with pain [34]. Seven of the reviewed
studies examined the effect of pain-related self-efficacy on treatment adherence. Two studies
measured pain-related self-efficacy using the Pain Self-Efficacy Questionnaire [27,32]. Two
studies used the Arthritis Self-Efficacy Scale [28,29]. Only one study used The Exercise Self-
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Efficacy Questionnaire [26], the Sports Injury Rehabilitation Survey [24], or a patient goal
expectancy rating [31] to measure pain-related self-efficacy.
Five of the seven studies that measured self-efficacy found a significant relationship
between self-efficacy and treatment adherence; whereby, low self-efficacy at baseline was
associated with reduced adherence to treatment recommendations post treatment
[24,26,27,29,32]. The strength of these relationships between pain-related self-efficacy and
treatment adherence was strong and positive in four out of the five studies [24,27,29,32]. One
study found low, but significant, positive correlations between pain-related self-efficacy
scores and treatment adherence scores [26]. The remaining two studies showed no
relationship between self-efficacy and treatment adherence [28,31].
2.3.4.2 Perceived disability Perceived disability in people with chronic pain is
generally assessed by reference to a person’s perceived ability to perform specific tasks (e.g.,
home duties) [35]. Three studies examined the effect of perceived disability on treatment
adherence, with varying descriptions. For example, some studies measured disability [28,29];
whereas, another study measured pain disability specifically [30]. Two studies measured
perceived disability using the Fibromyalgia Impact Questionnaire [28-29]. One study used
the Pain Disability Index [30] to measure perceived disability. Two studies found moderate to
strong negative associations between perceived disability and treatment adherence [28,29].
The one study that used the Perceived Disability Questionnaire showed no relationship [30].
Two of the three studies highlighted that experiencing high perceived disability at baseline
was associated with reduced adherence to treatment recommendations post treatment [28,29].
Moreover, pain patients with low perceived disability at baseline were more likely to actively
engage in treatment and adhere to treatment recommendations post treatment.
2.3.4.3 Catastrophising Pain catastrophising is characterised by the tendency to
exaggerate and ruminate negative cognitions and emotions during actual or perceived painful
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stimulation [36]. Three studies examined the relationship between catastrophising and
treatment adherence [27,26,32]. Two studies used the Pain Catastrophising Scale [26,32]. The
remaining study used the Catastrophising Scale of the Pain Response Self-Statements Scale
[27]. Two studies reported a strong negative relationship between catastrophising scores and
treatment adherence [27,32]. In these studies, individuals with high catastrophising scores at
baseline were at greater risk of early cessation of treatment and were less likely to adhere to
treatment recommendations over time than those with low catastrophising scores at baseline.
The remaining study found no relationship between catastrophising and treatment adherence
[26].
2.3.4.4 Control beliefs Control beliefs in relation to pain refer to an individual's belief
about the presence of factors that may facilitate or impede their ability to manage pain
symptoms [37]. Control beliefs were examined in three studies [25,26,33]. More specifically,
two studies examined Locus of Control [26,33], and one study examined the patient’s
perceived control of managing their pain as well as their perceived control of treatment [25].
All three studies showed no relationship between control belief scores and treatment
adherence.
2.3.4.5 Fear-avoidance beliefs Fear-avoidance is characterised by a trajectory of
avoidant behaviour due fear of pain, injury, or re-injury. This increases deterioration of
functioning and worsens pain over time; subsequently, trapping fear-avoidant individuals in a
cycle of disability and suffering [38]. Fear avoidance beliefs were examined in two studies
[26,27]. Nicholas et al [27] used the Tampa Scale for Kinesiophobia (TSK) and found a
negative correlation between fear-avoidance beliefs and treatment adherence. Whereby,
higher degrees of adherence to treatment recommendations were predictive of greater pre-
post treatment changes in fear-avoidance beliefs. However, Mannion et al [26] used the Fear-
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Avoidance Beliefs Questionnaire and found no significant association between fear-
avoidance beliefs and treatment adherence.
2.3.4.6 Other pain-related beliefs Perceived barriers relate to individual’s opinions of
the tangible and psychological costs associated with treatment adherence [39]. Perceived
barriers were examined in two studies [28,33]. The results from each study show a significant
negative association between perceived barriers and adherence to treatment
recommendations. Perceived benefits relate to individual’s beliefs in the efficacy of treatment
adherence to reduce risk or seriousness of chronic pain symptoms [39]. Perceived benefits
were examined in three studies [25,28,33], with two of those studies showing a significant
positive association [25,28], and one study showing no significant relationship [33].
A range of other pain-related beliefs were also investigated in the reviewed studies.
One study each examined perceived threats [33], perceived consequences [33], perceived
interference [25], expectation of treatment [33], and attitude toward treatment [30]. However,
given that each of the aforementioned pain-related beliefs were only examined in a single
study, the authors of this review considered there to be not enough evidence for reliable
conclusions to be drawn. Therefore, these studies are not discussed further.
2.4 Discussion
This review provides a systematic evaluation of the existing literature on pain-related
beliefs and their associations with treatment adherence among chronic pain patients. Ten
studies met the inclusion criteria for this review. Given the differences between the
descriptions of pain-related beliefs, the wide variety of treatment recommendations, and the
numerous methodologies included, a narrative methodology was selected. While this review
summarised the findings of each type of pain-related belief separately, it is important to note
that most of the reviewed studies examined a combination of these beliefs. The multiple
positive relationships identified here suggest that treatment adherence is determined by a
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combination of pain-related beliefs either supporting or inhibiting chronic pain patients’
ability to adhere to treatment recommendations over time.
2.4.1 Which pain-related beliefs have been investigated as correlates of treatment adherence
and what do the findings reveal?
Pain-related beliefs such as self-efficacy, perceived disability, catastrophising, fear-avoidance
beliefs as well as other pain beliefs such as perceived benefits and barriers of treatment have
been implicated in treatment adherence. To date, the pain-related belief with the most
empirical support is self-efficacy. The findings of the studies included in this review
consistently showed that high baseline levels of self-efficacy related to one’s ability to
manage pain were predictive of increased adherence to treatment recommendations.
According to the results of one study [26], increases in self-efficacy over the course of
treatment also predicted increased adherence. This result indicates that high self-efficacy at
the beginning of treatment is important for establishing treatment adherence mid and post-
treatment; additional research may be needed to confirm these findings.
Perceived disability was also reported as a predictor of treatment adherence among
chronic pain patients. The extent that patients perceive themselves to be disabled by their
chronic pain can strongly predict the likelihood that they will adhere to treatment regimens
[6]. Additional literature shows that self-efficacy has considerable implications for perceived
disability and treatment adherence [4,38]. Low self-efficacy beliefs appear to serve as a
cognitive barrier to patient’s attempts to function normally by increasing perceptions of a
long-term disability. That is, patients who exhibit high self-efficacy for managing chronic
pain symptoms are also more likely to have significantly higher pain thresholds, have fewer
severe symptoms, a better quality of life and possibly fewer problems with mobility and
suffering; thereby, reducing perceptions of disability [41]. This, in turn, may increase the
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likelihood that patients will demonstrate self-managing behaviours and adhere to treatment
over time.
The results of this review also suggest that pain patients who present with high
catastrophising beliefs about their pain prior to treatment may be at greater risk of non-
adherence to treatment recommendations compared to pain patients with low catastrophising
beliefs. According to Edwards et al [42], the construct of catastrophising is closely associated
with depression; including, magnification of pain-related symptoms, rumination about pain,
feelings of helplessness, as well as pessimism about treatment and pain-related outcomes.
Cognitions such as these are likely to impede patient’s ability to engage and persevere with
intervention. Subsequently, treatment aimed to reduce catastrophising and/or co-morbid
depression prior to or during the treatment of chronic pain may increase adherence behaviour.
This is likely to be relevant for all of the reviewed pain-related beliefs. That is, baseline
indicators of treatment barriers that are not identified and addressed prior to or during chronic
pain intervention may adversely impact treatment outcomes, and potentially worsen pain-
related beliefs and/or contribute to the development of co-morbid psychological problems
[43].
Contrary to expectation, no one construct of control was found to significantly predict
adherence to treatment recommendations over time. This finding may be the result of
heterogeneity between studies measuring control beliefs; with three different constructs of
control (i.e., Locus of Control, perceived control of managing pain, perceived control of
treatment) being measured among four studies. According to Skinner [44], the lack of clarity
about constructs has led to theoretical, empirical, and practical costs to the study of control
beliefs. Theoretically, the large number of terms used to describe control has produced
confusion about the boundaries on the topic of control, the interrelationships that exist among
constructs, and which constructs can be appropriately included in the research of control [44].
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Researchers may need to be more explicit in their assessment of control beliefs if they want
to operationalize their target constructs successfully.
According to additional literature [4,38,45], fear-avoidance beliefs are common
cognitive distortions among chronic pain patients. However, of the two studies which
explored this relationship in this review, only one found fear-avoidance beliefs to be
predictive of treatment adherence outcomes. According to this study [27], pain sufferers who
avoid activity because of fear of pain, injury, or re-injury may be less likely to engage and
adhere to treatment. Ongoing avoidance of treatment may then lead to additional health
problems and worsened disability; propelling patients in to what is known as the ‘fear
avoidance pain cycle’ [45]. However, given the limited number of studies investigating the
relationship between fear-avoidance beliefs and treatment adherence it is difficult to draw
conclusions from these findings. Finally, there is some evidence to suggest that perceived
benefits and barriers to treatment are correlated with adherence to recommendations. That is,
chronic pain patients who perceive benefits of treatment prior to the commencement of
intervention are more likely to adhere to recommendations post-treatment and over time
compared to patients who perceive no benefits or patients who perceive barriers of treatment
at the outset. These findings support the notion of the Health Belief Model (HBM), that
perceived benefits and barriers are important predictors of behaviour change [39]. However,
these findings should be interpreted with caution given that perceived benefits and barriers
were investigated in relatively few studies.
2.4.2 What methodological issues arise in studies of pain-related beliefs and treatment
adherence to date?
Similar to other systematic reviews, our review is bound to publication bias and we cannot
exclude that we may have missed some relevant studies, despite the fact that we used a highly
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sensitive search strategy and consulted an experienced librarian, as recommended by
Crumley et al. [46].
Given that pain-related beliefs and, in some cases, treatment adherence are examined
using self-report measures, it is possible that a relationship between beliefs and treatment
adherence reflect a social desirability response bias [47]. For example, perhaps some patients
chose to ‘fake bad’ or present a more favourable image of themselves in order to gain
approval. In addition, many studies examined the effects of psychological variables such as
depression on treatment adherence. Pain patients with unhelpful beliefs as well as depression
may make more negative assertions about his or her level of disability, potentially increasing
the likelihood of self-report bias [48]. While the majority of empirical findings support the
notion that pain-related beliefs impact the likelihood that treatment recommendations will be
adhered to, the relationship of pain-related beliefs to adherence behaviour alone may not be
sufficient to improve outcomes; with other factors, such as psychological variables,
potentially contributing to or mediating adherence changes. In this case, shared variance with
other factors such as depression may have obscured an independent relationship in the
analyses.
In addition, while pain-related beliefs and treatment adherence were measured at pre
and post treatment for all studies, no study measured the variables at the same time points
(e.g. 2 months, 6 months etc.). It is largely to be expected that adherence during treatment
will differ to some extent compared to adherence post-treatment as behaviour is self-directed
without the additional guidance and motivation provided by a treating clinician. However,
individual differences that exist among pain sufferers are also likely to dictate the
applicability and duration of use of particular strategies, adding further complexity and
limitation to obtaining homogeneity among time points. Curren et al [32] highlights this point
with the following example. Whereby, a patient who returns to a genuinely active lifestyle
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may not require ongoing adherence to pacing of activities compared to a patient who
experiences frequent and recurrent pain flares. These individual differences and varying
responses to intervention serve to illustrate the ongoing challenges of measuring adherence
and interpreting comparative studies.
Another issue relates to the various measures of adherence used in individual studies,
which resulted in different types of adherence being measured. That is, among the 10 studies
included in the review, 12 different measures of adherence were used. Some studies included
general measures of adherence (e.g., program attendance), other studies included specific
measures of adherence (e.g., adherence frequency), and a few studies included both general
and specific measures of adherence. This variation between studies made it difficult to collate
the measures used, potentially implicating the interpretation of findings. These differences
undeniably stem from the broad definition of adherence itself which implies various potential
methods of measurement. The all-encompassing nature of this definition is considered to be
beneficial, in many cases; however, research that aims to establish more homogenous
methodologies for measuring adherence, specifically, may be useful to better determine the
efficacy of treatment interventions and the implications for self-management.
Finally, the papers in this review investigate adherence to treatment recommendations
by means of various psychological approaches (e.g., Acceptance and Commitment Therapy,
ACT; Cognitive Behavioural Therapy, CBT). This is a theoretical issue which not only raises
questions about what constitutes appropriate treatment for chronic pain; it also appears to
have implications for adherence behaviour. For example, whereas, Curren et al [32] found
adherence to ACT-based treatment recommendations to be only weakly related to pain-
related beliefs. Nicholas et al [27] found adherence to CBT-based treatment
recommendations to be more strongly related to pain-related beliefs. More thorough
investigation of the differences between psychological (as well as the varying treatment
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approaches among other disciplines required for chronic pain management) approaches on
chronic pain outcomes is needed to progress the literature in this field.
2.4.3 What recommendations can be made based on research to-date?
More research is needed to further investigate the role that pain-related beliefs play in
treatment adherence. A longitudinal prospective study examining pain-related beliefs and
treatment adherence throughout treatment and post-treatment would provide the most
comprehensive review of the pain-related beliefs which impact on treatment adherence. This
proposed methodology is rare as only 3 out of the 10 studies included in this review
followed-up on pain patient’s adherence to treatment recommendations after 6 months
[29,30,33]. This is surprising as the literature has long established that patients who adhere to
treatment recommendations consistently for 6 to 12 months are significantly more likely to
maintain adherence behaviour over time and, thus, improve treatment outcomes [14].
Although the WHO continues to support the general notion that the longer treatment
recommendations are adhered to, the better the outcomes will be [7]. There appears to be an
enhanced understanding of individual characteristics (e.g., unhelpful pain beliefs, pain
intensity, co-morbid mental illness) which are likely to confound the period of time required
for adherence to improve treatment outcomes. For example, a patient with low pain intensity
may successfully manage pain symptoms by adhering to treatment recommendations for less
than 6 months compared to a patient with high levels of pain. Subsequently, research which
includes follow-up pre-post 6 months of treatment alongside investigations of individual
characteristics and their impact on the necessary time frame for adherence is needed.
Although the results from this review indicated that higher baseline self-efficacy,
lower perceived disability, and lower catastrophizing were variously related to improved
adherence (in the subset of studies measuring them), few studies measured how changes in
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these pain-related beliefs from pre to post treatment impact adherence. This research would
help to identify if specific pain-related beliefs (compared to others) and/or changes (e.g.,
improvements) in pain-related beliefs over time impact adherence behaviour. Currently, there
is evidence to support the efficacy of tailoring treatments to target specific pain-related
beliefs; this, in turn, may maximise treatment adherence outcomes. However, there needs to
be more consistency in the descriptions of pain-related beliefs measured in the literature to
allow for more meaningful collation of results [44].
This issue of inconsistency extends to the broader methodology used to measure
treatment adherence. Although, the Initiative on Methods, Measurement, and Pain
Assessment in Clinical Trials (IMMPACT) have highlighted the importance of obtaining
both objective (i.e., observation) and subjective (i.e., self-report) measures of pain outcomes
[49]; there remains no consensus on the optimal method for measuring adherence to
treatment recommendations (as indicated in Hall et al., 2014 systematic review), with the
majority of literature examining adherence using self-report diaries and/or non-standardised
questionnaires. Subsequently, it is recommended that research focus on establishing valid and
reliable methodological guidelines, such as: (1) consistent research designs and study
instruments, (2) use of standardised and specific (as opposed to general) adherence measures,
(3) larger sample sizes (increase the likelihood of detecting significant associations between
variables), and (4) improved control of potentially confounding variables (e.g.,
miscommunication between patient and provider, deficits in the knowledge or skills of the
patient, as well as age, gender, and cultural factors)[50]. Improving the methodology for
measuring adherence will allow for greater comparability of studies and an enhanced
understanding of the relevant predictors of treatment non-adherence.
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2.5 Conclusion
Collectively, the empirical findings from this review highlight the importance of
addressing pain-related beliefs prior to or during intervention, as improvement of unhelpful
beliefs may increase patients’ ability to engage in treatment and reduce disability outcomes.
In the studies reviewed, self-efficacy regarding one’s ability to manage pain appears to be the
most consistently measured pain-related belief in relation to treatment adherence, and its
effects may also influence other pain-related beliefs. Therefore, programs that specifically
incorporate self-efficacy enhancing components such as self-management education are
likely to yield important and beneficial effects that can be valuable in the management of
chronic pain. Given the immense scale of the problem, and the potential for efficacious
treatment adherence to significantly improve the lives of both pain sufferers, their families
and communities; it is very important that research in this area continue and thus provide a
more solid base on which to further develop chronic pain interventions.
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References
[1] Turk DC & Okifuji A. Psychological factors in chronic pain: evolution and revolution. J
Consult Clin Psychol 2002;70:678-690.
[2] Turner JA & Ersek M. Self-efficacy for managing pain is associated with disability,
depression, and pain coping among retirement community residents with chronic pain. J Pain
2005;6:471-479.
[3] Smeets RJEM, Vlaeyen JWS, Kester ADM, et al. Reduction of pain catastrophizing
mediates the outcome of both physical and cognitive-behavioral treatment in chronic low
back pain. J Pain 2006;7:261-271.
[4] Denison E, Ǻsenlӧf P & Lindberg P. Self-efficacy, fear-avoidance, and pain intensity as
predictors of disability in subacute and chronic musculoskeletal pain patients in primary
health care. Pain 2004;111:245-252.
[5] Baker TA, Buchanan NT & Corson N. Factors influencing chronic pain intensity in older
black women: examining depression, locus of control, and physical health. J Womens Health
2008;17:869-878.
[6] Alschuler KN, Theisen-Goodvich ME, Haig AJ, et al. A comparison of the relationship
between depression, perceived disability, and physical performance in persons with chronic
pain. Eur J Pain 2008;12:757-764.
[7] Sabatѐ E. Adherence to long-term therapies: Evidence for action. World Health
Organization 2003: Geneva.
[8] Demoulin C, Grosdent S, Capron L, et al. Effectiveness of a semi-intensive
multidisciplinary outpatient rehabilitation program in chronic low back pain. Joint Bone
Spine 2010;77:58-63.
![Page 113: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/113.jpg)
99
[9] Lambeek LC, van Mechelen W, Buijs PC, et al. An integrated care program to prevent
work disability due to chronic low back pain: a process evaluation within a randomized
control trial. BMC Musculoskelet Disord 2009;10:1-10.
[10] Dersh J, Polatin PB & Gatchel RJ. Chronic pain and psychopathology: research findings
and theoretical considerations. Psychosom Med 2002;64:773-786.
[11] Dworkin RH, Backonja M, Rowbotham MC, et al. Advances in neuropathic pain:
diagnosis, mechanisms, and treatment recommendations. Arch Neurol 2003;60:1524-1534.
[12] Maetzel A & Li L. The economic burden of low back pain: a review of studies published
between 1996 and 2001. Best Pract Res Clin Rheumatol 2002;16:23-30.
[13] Crandall S, Howlett S & Keysor JJ. Exercise adherence interventions for adults with
chronic musculoskeletal pain. Phys Ther 2013;93:17-21.
[14] Turk DC & Rudy TE. Neglected topics in the treatment of chronic pain patients: relapse,
noncompliance, and adherence enhancement. Pain 1991;44:5-28.
[15] Manchikanti L, Atluri S, Trescot A, et al. Monitoring opioid adherence in chronic pain
patients: tools, techniques and utility. Pain Physician 2008;11:1-26.
[16] Miaskowski C, Dodd MJ, West C, et al. Lack of adherence with the analgesic regimen: a
significant barrier to effective cancer pain management. J Clin Oncol 2001;19:4275-4279.
[17] Stanos S. Focused review of interdisciplinary pain rehabilitation programs for chronic
pain management. Curr Pain Headache Rep 2012;16:147-152.
[18] Burns JW, Kubilus A, Bruehl S, et al. Do changes in cognitive factors influence outcome
following multidisciplinary treatment for chronic pain? A cross-lagged panel analysis. J
Consult Clin Psychol 2003;71:81-91.
[19] Jensen MP, Turner JA & Romano JM. Changes in beliefs, catastrophizing and coping
are associated with improvement in multidisciplinary pain treatment. cross-lagged panel
analysis. J Consult Clin Psychol 2001;69:655-662.
![Page 114: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/114.jpg)
100
[20] Guzmân J, Esmail R, Karjalainen K, et al. Multidisciplinary rehabilitation for chronic
low back pain: a systematic review. BMJ 2001;322:1511-1516.
[21] Becker N, Sjøgren P, Bech P, et al. Treatment outcome of chronic non-malignant pain
patients managed in a Danish multidisciplinary pain centre compared to general practice: a
randomised control trial. Pain 2000;84:203-211.
[22] Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews
and meta-analysis: the PRISMA statement. PLoS Med 2009;6:1-6.
[23] Higgins JPT & Green S. Cochrane handbook for systematic reviews of interventions.
England: John Wiley & Sons, 2008.
[24] Coppack RJ, Kristensen J & Karaheorghis CI. Use of a goal setting intervention to
increase adherence to low back pain rehabilitation: a randomized control trial. Clin Rehabil
2012;26:1032-1042.
[25] Robinson ME, Bulcourf B, Atchison JW, et al. Compliance in pain rehabilitation: patient
and provider perspectives. Pain Med 2004;5:66-80.
[26] Mannion AF, Helbling D, Pulkovski N, et al. Spinal segmental stabilisation exercises for
chronic low back pain: programme adherence and its influence on clinical outcome. Eur
Spine J 2009;18:1881-1891.
[27] Nicholas MK, Asghari A, Corbett M, et al. Is adherence to pain self-management
strategies associated with improved pain, depression and disability in those with disabling
chronic pain? Eur J Pain 2012;16:93-104.
[28] Dobkin PL, Abrahamowicz M, Fitzcharles M, et al. Maintenance of exercise in women
with fibromyalgia. Arthritis Rheumatol 2005;53:724-731.
[29] Dobkin PL, Liu A, Abrahamowicz M, et al. Predictors of disability and pain six months
after the end of treatment for fibromyalgia. Clin J Pain 2010;26:23-29.
![Page 115: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/115.jpg)
101
[30] Glombiewski JA, Hartwich-Tersek J & Rief W. Attrition in cognitive-behavioral
treatment of chronic back pain. Clin J Pain 2010;26:593-601.
[31] Heapy A, Otis J, Marcus KS, Frantsve LM, et al. Intersession coping skill practice
mediates the relationship between readiness for self-management treatment and goal
accomplishment. Pain 2005;118:360-368.
[32] Curran C, Williams ACC & Potts HWW. Cognitive-behavioral therapy for persistent
pain: does adherence after treatment affect outcome? Euro J Pain 2009;13:178-188.
[33] Engstrӧm LO & Ӧberg B. Patient adherence in an individualized rehabilitation
programme: a clinical follow-up. Scand J Public Health 2005;33:11-18.
[34] Nicholas MK. The pain self-efficacy questionnaire: taking pain into account. Euro J
Pain 2007;11:153-163.
[35] Turk DC, Okifuji A, Sinclair JD, et al. Pain, disability, and physical functioning in
subgroups of patients with fibromyalgia. J Rheumatol 1996;23:1255-1262.
[36] Leung L. Pain Catastrophizing: An updated review. Indian J Psychol Med 2012;34:204-
217.
[37] Jensen MP & Karoly P. Control beliefs, coping efforts, and adjustment to chronic pain. J
Consul Clin Psychol 1991;59:431-438.
[38] Crombez G, Eccleston C, Damme S, et al. The fear avoidance model of chronic pain:
The next generation. Clin J Pain 2012; 28: 475-483.
[39] Janz NK & Becker MH. The health belief model: a decade later. Health Educ Q
1984;11:1-47.
[40] Arnstein P, Caudill M, Mandle CL, et al. Self-efficacy as a mediator of the relationship
between pain intensity, disability and depression in chronic pain patients. Pain 1999;80:483-
491.
![Page 116: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/116.jpg)
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[41] Lin C & Ward SE. Perceived self-efficacy and outcome expectancies in coping with
chronic low back pain. Res Nurs Health 1996;19:299-310.
[42] Edwards RR, Cahalan C, Mensing G, et al. Pain, catastrophizing, and depression in the
rheumatic diseases. Nat Rev Rheumatol 2011;7:216-224.
[43] Pfingsten M, Hildebrandt J, Leibing E, et al. Effectiveness of a multimodal treatment
program for chronic low-back pain. Pain 1997;73:77-85.
[44] Skinner EA. A guide to constructs of control. J Pers Soc Psychol 1996;71:549-570.
[45] Vlaeyen JWS & Linton SJ. Fear-avoidance and its consequences in chronic
musculoskeletal pain: a state of the art. Pain 2000;85:317-332.
[46] Crumley ET, Wiebe N, Cramer K, et al. Which resources should be used to identify
RCT/CCTs for systematic reviews: a systematic review. BMC Med Res Methodol 2005;5:1-
13.
[47] van de Mortel TF. Faking it: social desirability response bias in self-report research. Aust
J Adv Nurs 2008; 25:40-48.
[48] Logan DE, Claar RL & Scharff L. Social desirability response bias and self-report of
psychological distress in pediatric chronic pain patients. Pain 2008;136:366-372.
[49] Hazard RG, Fenwick JW, Kalisch SM, Reeves, RJ, Reid VS & Frymoyer JW.
Functional restoration with behavioral support: A one-year prospective study of patients with
chronic low-back pain, Spine 1989;14:157-161.
[50] Turk DC, Dworkin RH, Allen RR, et al. Core outcome domains for chronic pain clinical
trials: IMMPACT recommendations. Pain 2003;106:337-345.
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Chapter 3
Method
The chapters to follow will present two investigative studies (under review). Study
Two examines the links between chronic pain symptoms and affective disorders. This is a
retrospective study using network analysis, a novel approach which provided insights into the
relationship between chronic pain and psychological variables. Study Three addresses the
important question about treatment adherence and maintenance in chronic pain patients
following pain management intervention. This is a prospective longitudinal study assessing
chronic pain patients at pre-intervention (intake), post-intervention (discharge) and 3 to 6
months post-intervention (follow-up). Below, the methodology involved in undertaking each
study will be discussed in-depth before presenting Studies Two and Three individually as
subsequent chapters.
3.1 Study Two method expanded
3.1.1 Participants
The initial sample pool consisted of 743 chronic pain patients who had attended a pain
management program at The Victorian Rehabilitation Centre (TVRC) Pain Management
Clinic (PMC). The final sample comprised of 169 consenting chronic pain patients who had
received treatment from TVRC PMC between 2007 and 2016. The age of the participants at
the time they began treatment ranged from 22 to 80 years (M=49.72, SD=11.48). The final
sample comprised of 71 males (42%) with a mean age of 48.39 years (26 to 71 years) and 98
females (58%) with a mean age of 50.85 years (24 to 80 years).
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The sample was predominantly Australian born (N=123, 72.8%), with 4.7% (N=8)
born in Europe, 5.9% (N=10) born in England, 4.7% (N=8) born in Asia, 3.6% (N=6) born in
the United States, and 3% (N=5) born in Africa. The remaining 5.3% (N=9) did not specify
their country of birth. Fifty six percent of participants (N=94) were married, 19.5% (N=35)
were single, 11.3% (N=19) were divorced or separated, 4.7% (N=8) were in a defacto
relationship and 1.8% (N=3) were widowed. The remaining 6.7% (N=10) did not specify
their marital status.
Chronic pain conditions varied considerably among participants. For this reason, and
for ease of interpretation, they have been categorised according to participants’ primary pain
complaint, as follows: 87.6% (N=148) reported general musculoskeletal pain (e.g., back,
limbs), 8.3% (N=14) widespread pain (e.g., fibromyalgia), 2.4% (N=4) specific whiplash
pain, and 1.8% (N=3) headache. Among the participants in this sample, 56.2% (N=95) had
pain at three or more locations, 26.6% (N=45) had pain at two locations, and 17.2% (N=29)
had pain at a single location. Fifty five percent (N=94) of participants acquired chronic pain
in the past 0-5 years, 21.3% (N=36) in the past 5-10 years, 14.8% (N=25) in the past 10+
years, and 8.3% (N=14) did not specify a pain onset date.
3.1.2 Materials
Participants completed the following questionnaires: (1) Depression, Anxiety, and
Stress Scale, short form (DASS-21); (2) Pain Self-Efficacy Scale (PSEQ); (3) The TAMPA
Scale of Kinesiophobia (TSK); (4) The Survey of Pain Attitudes, revised version (SOPA-R)
and; (5) Perceived Disability Index (PDI). Cronbach’s alpha scores of greater than α = .70 are
considered sufficient for the use of a scale (DeVellis, 2003). Chronbach’s alpha is sensitive to
item number, as such scales with less than ten items which do not meet α = .70 or above
requirement should report the mean inter-item correlation which between .2 to .4 is
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considered sufficient reliability (Briggs & Cheek, 1986). All scales had a Cronbach’s alpha
score greater than or equal to α = .70. Descriptions of each questionnaire are detailed in the
measures section to follow.
3.1.3 Measures
3.1.3.1 Demographic information
Demographic information was collected from the intake assessment form. This
included current age and sex of the participant, marital status, and country of birth. Pain
characteristics detailing the presenting complaint and pain location, pain intensity and onset
date of pain (or injury) were also collected.
3.1.3.2 Affective symptoms
Affective symptoms were measured by the Depression Anxiety and Stress Scale 21
(DASS-21) is a shortened form of Lovibond and Lovibond’s (1995) original 42-item self-
report measure of depression, anxiety and stress. The DASS-21 is a 21-item self-report
questionnaire used to measure the severity of symptoms common to depression (e.g., ‘I felt
that life was meaningless’), anxiety (e.g., ‘I felt scared without any good reason’) and stress
(e.g., ‘I found it hard to wind down’). Given the specific interest in depression and anxiety
symptomatology, the current research utilised only the Depression and Anxiety subscales.
The DASS-21 is not a diagnostic tool but is widely used as a screening tool for psychiatric
symptoms. Participants were asked to respond to each item in terms of the presence of the
symptom over the last seven days. Each item is scored from zero (did not apply to me at all
over the last week) to three (applied to me very much or most of the time over the last week).
Scores for each subscale are summed and multiplied by two (for the 21 item short form) to
produce an overall score for each of depression, anxiety and stress. Scores for each subscale
can range from zero to 126 with higher scores reflecting elevated symptomatology. Henry
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and Crawford (2005) tested the validity of the DASS-21 on a large non-clinical sample (N =
1794). Chronbach’s alpha was α =.89 for the ‘depression’ scale, α =.82 for ‘anxiety’, α =.90
for ‘stress’ and α =.93 for the total ‘psychological adjustment’ scale. The current study used
two of the DASS subscales, Depression and Anxiety for analyses. In the present study,
Cronbach’s alpha was .96 alpha for both depression and anxiety
3.1.3.3 Pain self-efficacy
Pain Self-efficacy symptoms were measured by the Pain Self-Efficacy Questionnaire
(PSEQ; Nicholas, 1989) was developed as a behaviour specific measure of self-efficacy,
measuring participants’ confidence in their ability to perform a range of activities while in
pain. The PSEQ is a 10-item self-report questionnaire, covering a range of functions,
including household chores, socialising, work, as well as coping with pain without
medication. The scores are anchored with a 7-point Likert scale (0 = not at all confident to 6
= always confident) and participants are asked to indicate to what extent they agree with each
statement. Each item on the scale is worded positively and preceded by the phrase ‘I can’
(e.g., ‘I can enjoy things, despite pain’). The scores for each item are summed to produce a
total pain self-efficacy score and produce a range from 0 - 60, with higher scores indicating
clinically-significant functional levels and greater confidence in managing pain.
Psychometric testing of the PSEQ showed a high internal consistency (α = 0.92; van der
Maas et al., 2012). The PSEQ also has strong construct validity, with testing showing
evidence of the PSEQ’s sensitivity to change over time. The current study used the total
PSEQ score for analyses. In the present study, Cronbach’s alpha was .92.
3.1.3.4 Fear-avoidance beliefs
Fear avoidance beliefs were measured by the TAMPA Scale of Kinesiophobia (TSK;
Miller, Kori & Todd, 1991) was developed as a measure of fear of movement or (re)injury.
Kinesiophobia as an irrational and debilitating fear of physical movement and activity
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resulting from a feeling of vulnerability to painful (re)injury. The formulation of this scale
has been based on the model of fear avoidance, fear or work-related activities, fear of
movement, and fear of re-injury and has been linked to elements of catastrophic thinking
(Vlaeyan et al., 1995). The TSK is a 17-item self-report questionnaire and each item is scored
from one (strongly disagree) to four (strongly agree). ‘I’m afraid that I might injure myself if
I exercise’ is an example of an item on the TSK. The total score ranges between 17 and 68
with a high value on TSK indicating a high degree of kinesiophobia (i.e., an excessive,
irrational and debilitating fear of physical movement and activity due to injury or re-injury).
Roelofs et al (2004) tested the validity of the TSK on a sample of chronic low back pain
(CLBP) and fibromyalgia patients. The current study used the total TAMPA score for
analyses. In the present study, Cronbach’s alpha was .76.
3.1.3.5 Perceived control
Perceived Control was measured by the Survey of Pain Attitudes revised version
(SOPA-R; Jensen & Karoly, 1989) is a measure of beliefs which possibly influence long term
adjustment for people with chronic pain. The SOPA-R requires patients to indicate their level
of agreement to 35 items using a 5-point Likert scale (0 = this is very untrue for me to 4 =
this is very true for me) to indicate the extent to which they agree with statements such as
‘when I am hurting, I deserve to be treated with care and concern’. The beliefs measured are
divided into two general categories: (1) Adaptive Beliefs (i.e., beliefs that are thought to
contribute to less pain and disability over time) which includes two subscales (Control and
Emotion), and (2) Maladaptive Beliefs (i.e., beliefs that are thought to contribute to greater
pain and disability over time) which includes five subscales (Disability, Harm, Medication,
Solicitude, Medical Cure). Of the seven SOPA-R subscales, the current study used the
Control subscale (5 items), with possible scores ranging from zero to 20. Lower scores on the
SOPA-R Control subscale indicate low perceived control. Psychometric testing of the SOPA-
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R showed internal consistency ratings for the seven SOPA-R subscales to range from α = .65
to .82 (Jensen, Turner & Romano, 2000). In the present study, Cronbach’s alpha was .83.
3.1.3.6 Pain disability
Pain Disability was measured by the Pain Disability Index (PDI) was developed to measure
the impact that pain has on the ability of a person to participate in essential life activities
(Pollard, 1984). The PDI is an inventory that asks respondents the rate to which pain
interferes with their functioning pertaining to six broad areas (items): family/home
responsibilities (item 1), recreation (item 2), social activity (item 3), occupation (item 4),
sexual behaviour (item 5), and life-support activity (item 6). Scores are assigned based on an
11-point Likert scale ranging from 0 (no disability) to 10 (worst disability). Each item is
explained under its respective heading; for example, ‘Recreation – This category includes
hobbies, sports, and other similar leisure time activities’. The total score ranges from 0-60
with higher PDI scores indicating greater disability associated with pain. The PDI has been
found to be internally consistent (Cronbach’s Alpha = .87) and to exhibit a factor structure
that represents disability in voluntary and obligatory activities shown to be consistent with
the model of disability proposed by Fordyce (1984). The current study used the total PDI
score for analyses. In the present study, Cronbach’s alpha was .85.
3.1.4 Procedure
The Deakin University Human Research Ethics Committee (DU HREC: 2012-147)
and The Melbourne Clinic Research Ethics Committee (TMC REC: 206) approved this
research (refer to Appendix A and B). As a requirement to access the TVRC medical records,
the researchers of this study were required to sign a confidentiality agreement. Participant
information was gained retrospectively from medical records. To ethically access this
information, all patients, aged 18 years or older, who had received pain treatment at TVRC
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were sent a letter from the TVRC director (Appendix C), a Plain Language Statement
(Appendix D), and a consent form (Appendix E) inviting them to participate in the study.
Participants were informed that the study was voluntary, that their participation would not
impede their relationship with TVRC, and that they may withdraw participation from the
study at any time without negative consequences. Only patients who consented, were
included in the study.
Each archival medical record comprised one assessment form containing
demographic information and details of pain characteristics which was obtained during
participants’ initial consultation by TVRC clinicians. At the time, the intake assessment took
approximately 30 to 45 minutes to complete. Medical records also contained a battery of
questionnaires (DASS-21, PSEQ, TAMPA, SOPA-R, and PDI) completed by participants
pre-treatment. The battery of questionnaires took participants approximately 15 minutes to
complete. Participants were not provided with any incentive or reward to participate in this
study.
3.2 Study Three method expanded
3.2.1 Participants
The initial sample consisted of 169 chronic pain patients who had completed
treatment at The Victorian Rehabilitation Centre (TVRC) Pain Management Clinic between
2007 and 2016. Participants were excluded from the study for any one or more of the
following reasons: 1) incomplete time points, 2) data had expired beyond the timeframe of
data collection for the study, and 3) no consent or return follow-up measures provided. This
resulted in a total sample of 61 eligible chronic pain patients who had received treatment
from TVRC PMC between 2014 to 2016 who completed the study to follow-up. This is equal
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to an attrition rate of 64%. Figure 5 outlines participant numbers, measures administered by
time-point as well as inclusion and exclusion criteria for Studies 2 and 3.
The age of the participants in the final sample at the time they began treatment ranged
from 31 to 72 years (M=54.28, SD=10.32). Of the 61 participants, 36 males (59%) with a
mean age of 47 years and 25 females (41%) with a mean age of 54.2 years. The sample was
predominantly Australian born (N=44, 72.3%), with 12% (N=7) born in Europe, 6.4% (N=4)
born in Asia, and 3.5% (N=2) born in the United States. The remaining 5.8% (N=4) did not
specify their country of birth. Forty three percent (N=26) were married, 28.3% (N=17) were
divorced or separated, 14% (N=9) were single, and 7.4% (N=5) were in a defacto
relationship. The remaining 7.3% (N=4) did not specify their marital status. The majority of
participants experienced musculoskeletal pain (N=39, 64.8%), 14.3% (N=9) widespread pain
(e.g., fibromyalgia), 10.6% (N=6) specific whiplash pain, 6.1% (N=4) headache, and 4.2%
(N=3) abdominal pain. Among the participants in this sample, 54.2% (N=33) had pain at
three or more locations, 26.7% (N=16) had pain at two locations, and 19.1% (N=12) had pain
at a single location.
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Study 2 Study 3
Figure 5. Participant numbers, measures administered by time-point and inclusion and
exclusion criteria for Studies 2 and 3
Initial sample (N = 743) consisted of
all available patient records
Incl
usi
on
E
xcl
usi
on
M
easu
res
by t
ime-p
oin
t
Initial sample (N = 169) consisted of
all participants included in Study 2
Measures assessed at
Time 1 (pre-treatment):
DASS-21
PSEQ
TAMPA
SOPA-R
PDI
1. No consent (n = 423)
2. Incomplete measures
(n = 147)
3. Missing data exceeded 20%
(n = 4)
Measures assessed at
Time 1 (pre-treatment), Time 2
(discharge) & Time 3 (3-6 months):
DASS-21
PSEQ
TAMPA
SOPA-R (Time 1 only)
TMQ (Time 3 only)
1. No consent (n = 52)
2. Incomplete measures, across
time-points (n = 48)
3. Data expired beyond time of
data collection (n = 18)
Final sample (N = 61)
Attrition rate – 64%
Final sample (N = 169)
1. TVRC PMC patients between
2007 – 2016
2. Completion of measures
1. TVRC PMC patients between
2014 – 2016
2. Completion of measures at
three time-points
Init
ial
N
Fin
al
N
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3.2.2 Treatment
The treatment programs were individually tailored to the patient goals and needs
identified during the multidisciplinary assessment. The range of length for the programs was
between 6 and 12 weeks’ duration, 2-3 days per week for 1-4 hours per day, depending on
patient goals, needs, and individual capacity and ability to attend.
The programs were all delivered by a multidisciplinary team including a
physiotherapist (delivering land and water based therapy weekly), psychologist (all
participants had individual sessions with the psychologist weekly), and occupational therapist
(delivering weekly sessions focused on functional and vocational goals). All clinicians were
fully qualified and experienced practitioners working within a private pain clinic.
All participants received individual treatment sessions from all three disciplines, and
those who were appropriate to attend group education and relaxation sessions (no major
psychological, physical, language or intellectual barriers, not hearing impaired, etc.) were
also encouraged to attend group sessions. The group sessions included 4-6 participants in
each group, and the education topics and relaxation training sessions were delivered over a
period of 6 weeks (2-3 days per week). Those who did not attend the group sessions had this
educational content and relaxation training delivered within their individual sessions. All
participants were given a copy of the same patient manual, outlining the key concepts and
recommendations from each of the three disciplines involved in delivering the pain
management program (physiotherapist, psychologist, and occupational therapist).
3.2.3 Materials
Three batteries of questionnaires were used in this study. Each battery contained the
same questionnaires, with the exception of the Treatment Maintenance Questionnaire (TMQ)
which was administered only at time three (3 to 6 months follow-up). The latter questionnaire
asked participants to report their adherence behaviour to various activities recommended to
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them during their treatment at TVRC. Table 3 outlines the measures included at each time
point. Refer to Appendix J and K for the complete battery of questionnaires. As the majority
of questionnaires for this study are the same as the questionnaires used in study two, detail of
these measures and the psychometric properties will not be repeated here. Please refer back to
the materials section of study two in this chapter for these details. The additional measure, the
TMQ is described below.
Table 3. Study three time points and Cronbach’s alpha measures included
Time Point Measures α
Pre-Treatment (baseline) Depression Anxiety and Stress Scale
Pain Self-Efficacy Questionnaire
The TAMPA Scale of Kinesiophobia
Survey of Pain Attitudes
.90
.93
.88
.60
Post-Treatment (discharge) Depression Anxiety and Stress Scale .95
Pain Self-Efficacy Questionnaire
The TAMPA Scale of Kinesiophobia
.95
.77
Post-Treatment (3-6 months) Depression Anxiety and Stress Scale .93
Pain Self-Efficacy Questionnaire
The TAMPA Scale of Kinesiophobia
Treatment Maintenance Questionnaire
.95
.83
.87
3.2.4 Measures
3.2.3.1 Depression and Anxiety
The Depression, Anxiety, and Stress Scale (DASS-21; Lovibond & Lovibond, 1995)
was included at each time point in this study. For more information on this scale refer back to
the Measures section for Study Two.
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3.2.3.2 Pain Self-Efficacy Questionnaire
The Pain Self-Efficacy Questionnaire (PSEQ; Nicholas, 1989) was measured at each
time point in this study. For more information on this scale refer back to the Measures section
for Study Two.
3.2.3.3 The TAMPA Scale of Kinesiophobia
The TAMPA Scale of Kinesiophobia (TSK; Miller et al., 1991) was measured at each
time point in this study. For more information on this scale refer back to the Measures section
for Study Two.
3.2.3.4 Survey of Pain Attitudes
The 5-item disability subscale of the Survey of Pain Attitudes, revised version
(SOPA-R; Jensen, Karoly, & Huger, 1987) was used to measure patient’s self-perceived
disability at baseline due to their chronic pain. For more information on the SOPA-R refer to
section 3.1.3.5 of Study Two.
3.2.3.4 Treatment Maintenance Questionnaire
The Treatment Maintenance Questionnaire (TMQ) was developed by the researchers
for this study. The TMQ is a 20-item questionnaire which was designed to measure
adherence behaviour post-treatment. It was included in the final battery of questionnaires for
participants to return as part of their follow-up measures. The questionnaire assessed
adherence to a range of recommended activities specific to the pain treatment provided as
part of TVRC PMP. Participants were asked to rate their level of adherence on a 4 point
Likert Scale (where 1 = I use this strategy not at all to 4 = I use this strategy all of the time)
in relation to five broad categories of treatment recommendations (regular exercise;
biomechanics; relaxation techniques; activity pacing; stress and mood management).
Participants were informed that they could score a zero if they had not been recommended to
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use a particular strategy listed (0 = I was not recommended to use this strategy). Each
category contained 3 items, with the exception of stress and mood management which
contained 4 items. In total, participants could score between 0 and 64 on the TMQ.
3.2.4 Procedure
The Deakin University Human Research Ethics Committee (DU HREC: 2012-147)
and The Melbourne Clinic Research Ethics Committee (TMC REC: 206) granted Ethics
approval for this study (see Appendix A and B). As a requirement to access the TVRC
medical records, the researchers of this study were required to sign a confidentiality
agreement. Participant information was gained retrospectively from medical records. In order
to ethically access this information, all patients, aged 18 years or older, who had received
pain treatment at TVRC were sent a letter from the TVRC director (Appendix G), a Plain
Language Statement (Appendix H), and a consent form (see Appendix I) inviting them to
participate in the study. Participants were informed that the study was voluntary, that their
participation would not impede their relationship with TVRC, and that they may withdraw
participation from the study at any time without negative consequences. Only the patients
who consented to participate in Study Three (after reviewing the cover letter and Plain
Language Statement) had their follow-up data entered into the research database. Patients
who participated in Study Two who had already attended their follow-up appointment, and
whose discharge period had not exceeded that of six months, were mailed out the cover letter,
Plain Language Statement, consent form, and questionnaire booklet, with reply paid
envelope. Those who agreed to participate returned their signed consent forms and
questionnaire booklets in the reply-paid envelope provided.
Each archival medical record comprised two assessment forms containing
demographic information and details of pain characteristics which were obtained by TVRC
clinicians during participants’ initial consultation and at program completion. At the time,
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both assessments took approximately 30 to 45 minutes to complete. Medical records also
contained three batteries of questionnaires (DASS-21, PSEQ, TAMPA, SOPA-R, and PDI)
completed by participants at each time-point; pre-treatment, discharge, and 3-6 months post-
treatment. Each battery of questionnaires took participants approximately 15-20 minutes to
complete. Participants were not provided with any incentive or reward to participate in this
study.
As part of the follow-up procedure at TVRC, patients are required to attend a three
and/or six month follow-up appointment to review their progress post-treatment. This follow-
up period was considered by the researchers to be more accommodating for the tail-end of
potential participants who were, at the time, still completing their treatment. This meant that
patients could participate in the study once the minimum three month period had elapsed,
ensuring that all potential participant data could be included in the study.
A data tracking file was kept with detailed records of each time point, the date that
each participant was due to receive each questionnaire (i.e. the date each participant would be
discharged and expected for a follow-up appointment). The data from the returned
questionnaire booklets were entered into SPSS (version 21; IBM, 2013). A record was kept of
the date each questionnaire was sent out and the date it was received back. Participants who
did not return a questionnaire were followed up with one reminder phone call provided by the
principle researcher of the study and re-sent the study materials via mail if their voluntary
consent was ongoing.
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References
Briggs, S. R & Cheek, J. M. (1986). The role of factor analysis in the development and
evaluation of personality scales. Journal of Personality, 54(1), 106-148.
DeVellis, R. (2003). Scale development: theory and applications: Theory and application.
Thousand Okas, CA: Sage.
Fordyce, W.E., Lansky, D., Calsyn, D.A., Shelton, J.L., Stolov, W.C & Rock, D.L. (1984).
Pain measurement and pain behaviour. Pain, 18, 53-69.
Henry, J. D & Crawford, J. R. (2005). The short-form version of the Depression Anxiety
Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical
sample. British Journal of Clinical Psychology, 44(2), 227-239.
IBM Corporation. (2013). IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY:
IBM Corp.
Jensen, M. P & Karoly, P. (1989). Revision and cross-validation of the Survey of
PainAttitudes. Paper presented at the 10th Annual Scientific Sessions of the Society of
Behavioral Medicine, San Francisco, CA.
Jensen, M. P., Karoly, P & Huger, R. (1987). The development and preliminary validation of
an instrument to assess patients’ attitudes toward pain. Journal of Psychosomatic
Research, 31(3), 393-400.
Jensen, M., Turner, J & Romano, J. (2000). Pain belief assessment: A comparison of short
and long versions of the Survey of Pain Attitudes. Journal of Pain, 1, 138-150.
Lovibond, S. H & Lovibond, P. F. (1995). Manual for the Depression Anxiety Stress Scales
(DASS). New South Wales: Psychology Foundation Monograph.
Miller, R., Kori, S & Todd, D. (1991). The Tampa Scale of Kinesiophobia. Unpublished
report.
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118
Nicholas, M. K. (1989). Self-efficacy and chronic pain. Paper presented at the annual
conference of the British Psychological Society, St. Andrews.
Pollard, C. A. (1984). Preliminary validity study of the pain disability index. Perceptual and
Motor Skills, 59(3), 974.
Roelofs, J., Goubert, L., Peters, M. L., Vlaeyen, J. W & Crombez, G. (2004). The Tampa
Scale of Kinesiophobia: Further examination of psychometric properties in patients
with chronic low back pain and fibromyalgia. European Journal of Pain, 8(5), 495-502.
van der Maas, L. C. C., de Vet, H. C. W., Köke, A., Bosscher, R. J & Peters, M. L. (2012).
Psychometric properties of the pain self-efficacy questionnaire (PSEQ): Validation,
prediction, and discrimination quality of the Dutch version. European Journal of
Psychological Assessment, 28, 68-75.
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Chapter 4
Study Two: A network analysis of the links between chronic pain symptoms and
affective disorders1
Emma Thompson1, Jaclyn Broadent1, Matthew Fuller-Tyszkiewicz1, Melanie Bertino1,2 and
Petra Staiger1
1 School of Psychology, Deakin University, Burwood
2 The Victorian Rehabilitation Centre
Word Count: 4,500; no. of references: 71; no. of tables: 1; no. of figures: 1
Declaration of interest: The authors report no conflicts of interest or financial disclosures.
The authors alone are responsible for the content and writing of the paper.
Correspondence:
Dr Jaclyn Broadbent
Deakin University, School of Psychology
221 Burwood Hwy, Burwood, Victoria, Australia 3125
Email: [email protected]
Phone: +61 3 92443043
Fax: +61 3 92446858
1 This paper is currently under review for publication to the British Journal of Health
Psychology (BJHP). BJHP have specific guidelines for structure, formatting and referencing.
This paper was prepared in accordance with those guidelines
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Abstract
Objective. A range of psychological constructs, including perceived pain, self-efficacy, and
pain avoidance, have been proposed to account for the comorbidity of chronic pain and
affective disorder symptoms. Despite the likely inter-relation among these constructs, few
studies have explored these predictors simultaneously. As such, the relative contributions of
these psychological influences remain an open question. The present study uses a novel,
network model approach to help to identify the key psychological contributors to the pain-
affective disorder link.
Design. A cross-sectional design was implemented. The sample comprised 169 chronic pain
patients (Mage 49.82; range 22-80 years; 58% female) admitted to a metropolitan chronic pain
clinic in Victoria, Australia.
Method. Participants completed self-report measures of anxiety, depressive, and pain
symptoms, pain self-efficacy, fear avoidance beliefs, perceived control, and pain-related
disability.
Results. Network analysis identified self-efficacy, fear avoidance, and perceived disability as
key constructs in the relationship between pain and affective disorders, albeit in different
ways. While self-efficacy appeared to have direct links to other constructs in the network
model, fear avoidance and perceived disability seemed to function more as mediators, linking
other constructs in the model. Perceived control and anxiety were found to be less influential
in the model.
Conclusions. Collectively, these results suggest that targeted treatment of self-efficacy, fear
avoidance, and perceived disability may disrupt the link between pain experience and
affective disorder symptoms. Given their independent links to pain and affective disorder
symptoms, targeting of all three psychological constructs may be the most beneficial
approach.
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Key words: Pain; cognitive factors; depression; anxiety; fear-avoidance; network analysis
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4.1 Introduction
Depression and anxiety are common mental health problems with elevated prevalence
rates among chronic pain sufferers relative to rates found in the general population
(Demyttenaere et al., 2007; Means-Christensen, Roy-Byrne, Sherbourne, Craske, & Stein,
2008). Accumulated evidence suggests that this relationship between chronic pain and
affective disorder symptoms may be causal and bidirectional (e.g., Edwards et al., 2007;
Gerrits, van Marwijk, van Oppen, van der Horst, & Pennix, 2015; Kroenke et al., 2011).
Evidence also suggests that these prospective effects may be underpinned by a variety of
psychological mechanisms that influence the way an individual processes pain-related
information and perceives her/his capacity to manage their condition (Campbell, Clauw, &
Keefe, 2003: Gatchel, Peng, Peters, Fuchs, & Turk, 2007). The present study utilises a novel,
network-based approach to identify: (i) how well psychological processes identified in extant
literature account for the relationship between pain severity and affective disorder symptoms,
and (ii) which of these psychological processes are most influential for explaining the noted
co-occurrence of these conditions.
4.1.1 Psychological mechanisms linking affective disorder and pain symptoms
The experience of chronic pain is associated with a range of pain-related beliefs that
may both arise from and contribute to these pain symptoms. Perceptions of intense, enduring
pain symptoms are likely to shape the sufferer’s beliefs about their level of perceived
disability, control over their symptoms and prognosis, and pain-related self-efficacy (Baird &
Sheffield, 2016; Cross, March, Lapsley, Byrne, & Brooks, 2006; Denison, Asenlöf, &
Lindberg, 2004; Menezes Costa, Maher, McAuley, Hancock, & Smeets, 2011; Lau-Walker,
2006). These beliefs are inter-related (Baird & Sheffield, 2016; Keefe, Rumble, Scipio,
Giordano, & Perri, 2004), and may influence each other. For instance, an individual’s
perceived self-efficacy in dealing with her/his symptoms may influence perceived disability
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(Jackson, Wang, Wang, & Fan, 2014). Similarly, level of perceived disability may be the
basis for determining the level of control one exerts over efforts to reduce pain symptoms –
including the decision to rely on primarily passive or active self-management strategies
(Blyth, March, Nicholas, & Cousins, 2005).
Unfortunately, these pain-related beliefs may have a self-reinforcing nature,
impacting the extent to which individuals engage in activities to reduce or self-manage pain
symptoms and, in turn, the extent to which their symptoms improve, persist, or worsen over
time (French et al., 2000). Over time, these negative pain-related beliefs may also engender
feelings of helplessness regarding their pain symptoms, and in turn, confer risk for depressive
and anxiety symptoms as the individual recognises the severity of their symptoms, level of
impairment, and inability to improve their health (Allaz & Cedraschi, 2015).
Whilst a person’s subjective pain ratings may at times be predictable and expected
given the extent of preceding tissue damage, it is also clear that some individuals are more
likely than others to report intense pain experiences; regardless of whether the pain is of
neuropathic or nociceptive origin (Butler & Moseley, 2013). For instance, individuals with
fear avoidance beliefs tend to be hyper-vigilant to signs of pain, to be fearful or concerned
that certain movements that may aggravate pain, and have difficulty shifting away from pain-
related thoughts (Ramírez-Maestre, Esteve & López-Martínez, 2014). They are also more
likely to over-predict the intensity of pain they will experience in the future (Pfingsten et al.,
2001). Individuals with depression and anxiety show similar biases in information
processing, with particular focus on negative evaluations of the self, the world and the future
(i.e. Beck’s cognitive triad; Beck, 1976), catastrophising beliefs, and underestimating one’s
ability to cope with difficult situations (Beck & Emery, 1985). Together, these cognitive
distortions may serve to increase an individuals’ perceived intensity of pain symptoms, their
perceived level of disability, decrease their sense of control over their pain, and reduce their
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self-efficacy (i.e. confidence) in being able to self-manage their pain symptoms (Pincus &
Morley, 2001).
Taken together, this pattern of findings highlights a complex network of inter-related
and potentially mutually influencing psychological factors that may perpetuate the link
between affective disorders and pain symptom experience. However, the inter-connectedness
of these constructs makes it difficult to identify a clear direction of effects to plausibly test
using a longitudinal design. This inter-connectedness of symptoms also makes it difficult to
identify the psychological factors that are most influential for the relationship between
affective disorders and pain symptoms.
4.1.2 A network perspective on psychological influences on affective and pain symptoms
One intermediary step that may help to direct future efforts at longitudinal evaluation
of proposed mediation pathways is network analysis. In standard implementation
(Constantini et al., 2015), this analytic approach derives a visual (and numeric) network of
associations among variables from a partial correlation matrix. In addition to highlighting the
strength of association a variable has with another specific variable (as per a bivariate
correlation), network analysis provides summary metrics that indicate across all associations
how strongly related an individual variable is to other modelled variables and, by extension,
indicates its influence. These summary metrics break down the influence of a variable in
terms of total strength of associations with other variables (called ‘strength’ in network
analysis parlance), as well as direct links (‘closeness’) and whether the variable functions to
link other constructs in the model that are not directly related (‘betweenness’).
By using partial correlations between modelled variables instead of bivariate
correlations, the model shows any residual relationships that exist among variables after
controlling for all other modelled variables. In this way, shared variance among a variety of
putative predictors are removed, and it is easier to ascertain which variables may be most
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influential for one or more outcome variables of interest. In cases such as the present study,
where modelled variables are all anticipated to correlate to some extent, evaluation of the
number and strength of these partial correlations helps to identify variables that may be most
influential in the network model and for which variables they may be most influential.
4.1.3 The present study
Hence, the present study augmented correlational analyses with network analysis to
gain further insights into the role of specific pain beliefs in affective disorder and pain
severity among persistent pain patients. Based on prior research, it was anticipated that
bivariate correlational analyses would confirm each of these pain-specific psychological
variables (perceived disability due to pain, perceived control over pain, self-efficacy for pain
self-management, and pain related fear-avoidance beliefs) are inter-related, and also relate to
pain intensity and affective disorder symptom severity (anxiety and depression). It was
further anticipated that pain intensity would be related to these affective disorder symptoms.
To our knowledge, no prior studies have tested all of these psychological factors as predictors
of affective disorder symptoms or pain intensity within the same model. As such, we have no
hypotheses about which of the psychological factors will be most influential. Nevertheless,
we will utilise centrality measures from the network analysis to make recommendations about
which variables may be most important targets for further testing, in better understanding the
relationships between pain symptoms, affective disorder symptoms, and pain-related
cognitions. This is also likely to be beneficial in determining treatment targets for early
intervention and prevention work with pain sufferers.
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4.2 Method
4.2.1 Participants
In the current study, 743 patients assessed at [anonymous pain clinic] were originally
invited to participate in the research. The final sample consisted of 169 consenting chronic
pain patients between 22 to 80 years of age (M = 49.82, SD = 11.31) who had received
treatment from [anonymous pain clinic] between 2007 and 2016. Entry into the treatment
program is based on an intake assessment conducted by a multidisciplinary team comprising
a pain specialist physician, occupational therapist, psychologist, and physiotherapist.
Diagnosis was based on the presenting symptoms via subjective report in addition to
physical, psychological, and functional examinations.
4.2.2 Measures
4.2.2.1 Demographics. Demographic information was collected from the intake
assessment form. This included current age and sex of the participant, marital status, and
country of birth. Pain characteristics detailing the presenting complaint and pain location,
average pain intensity on the Numerical Rating Scale (NRS; rated 0-10), and onset date of
pain (or injury) were also collected.
4.2.2.2 Affective symptoms. Depression and anxiety subscales from the 21-item
Depression Anxiety Stress Scale (DASS-21; Lovibond & Lovibond, 1995) were used to
evaluate level of depressive and anxiety symptoms. Higher scores reflect elevated
symptomatology. In the present study, Cronbach’s alpha was .96 for both the depression and
anxiety subscales.
4.2.2.3 Pain self-efficacy. The 10-item Pain Self-Efficacy Questionnaire (PSEQ;
Nicholas, 1989) was used to measure confidence in participants’ ability to perform a range of
activities while in pain. Participants reported how confident they felt performing a range of
functions, including household chores, socialising, work, and coping with pain without
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medication. Higher scores indicate higher levels of pain self-efficacy e.g. greater confidence
in managing pain. Cronbach’s alpha was .92 in the present study. Both the PSEQ and DASS-
21 are part of the core recommended measures currently included in the electronic Persistent
Pain Outcomes Centre (ePPOC) national benchmarking evaluation, for both government
funded and privatised pain management clinics in Australia (see
http://ahsri.uow.edu.au/eppoc/index.html).
4.2.2.4 Fear-avoidance beliefs. The 17-item TAMPA Scale of Kinesiophobia (TSK;
Miller, Kori, & Todd, 1991) was used to measure fear of movement or (re)injury and consists
of two subscales: ‘activity avoidance’ (i.e., avoiding movements connected with physical
activity) and ‘somatic focus’ (i.e., pain is interpreted as a sign of harmful bodily processes).
Higher scores indicate stronger perceptions of each subscale e.g. greater fear of movement or
(re)injury (Swinkels-Meewisse et al., 2003). The internal consistency was alpha = .76 in the
present study.
4.2.2.5 Perceived control. The 35-item Survey of Pain Attitudes, revised version
(SOPA-R; Jensen & Karoly, 1991) was used to measure the influence of beliefs and feelings
on long term adjustment for people with chronic pain. Of the seven subscales included in the
SOPA-R (i.e., disability, harm, medication, solicitude, medical cure, control, and emotion),
the current study included the ‘control’ subscale only; with low scores indicating low
perceived control. In the current study, Cronbach’s alpha was .83.
4.2.2.6 Pain disability. The Pain Disability Index (PDI) was used to measure the self-
perceived impact that pain has on the ability of a person to participate in essential life
activities. Participants rate the level of interference that pain has in six broad areas of
functioning: family/home responsibilities, recreation, social activity, occupation, sexual
behaviour, and life-support activity. Higher PDI scores indicate greater disability associated
with pain. Cronbach’s alpha was .85 in the present study.
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4.2.3 Procedure
[anonymous University] and [anonymous pain clinic] ethics committees’ approval
was granted for this study. Participants included were 18 years or older who had received
treatment from [anonymous pain clinic] between 2007 and 2016. Participants completed a
battery of questionnaires (DASS-21, PSEQ, TAMPA, SOPA-R, and PDI) at admission via
self-report measures. Files were accessed for consenting participants only. Participants who
had not completed at least 60 percent of the full battery of questionnaires were later excluded.
4.2.4 Analytic strategy
Network analyses were conducted using the qgraph (Epskamp, Cramer, Waldorp,
Schmittmann, & Borsboom, 2012) and parcor (Krämer, Schäfer, & Boulesteix, 2009)
packages within the statistical platform R. The adaptive least absolute shrinkage and selection
operator (LASSO) approach was implemented as an efficient means for eliminating spurious,
non-zero associations (Krämer et al., 2009).
The generated network consists of variables (referred to as nodes in network
analysis), connected by lines (edges). Several aspects of the visual network map are
informative. First, the width and colour of edges indicate the strength (with wider edges
indicating stronger partial correlations) and direction (positive associations typically as green
lines and negative association as red lines) of associations between nodes. The absence of a
direct line connecting two nodes suggests that, after adjusting for all other nodes in the
model, the remaining (or partial) association between these two nodes is not reliably different
from zero. Nevertheless, two nodes may still be associated via a third node that links them
together indirectly. Second, the location of nodes within the network map help to identify
influential nodes and also clusters of nodes. Nodes cluster within the network when they are
strongly correlated. The more peripherally a node is located, the less correlated it is to other
nodes.
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As with other statistical techniques, visual scrutiny does not always lead to conclusive
interpretation of results. Consequently, quantitative centrality measures are also reported in
order to help identify nodes that are most influential in the network map. A variety of such
measures is available; however, the present study relies on the three most commonly reported
in the literature: strength, closeness, and betweenness. Strength refers to the overall relation
of a node to others in the model, and is calculated by aggregating all (absolute values of)
partial correlations involving a particular node. Higher scores reflects greater strength of
connectivity within the model. Closeness refers to how quickly a node connects to other
nodes within the model, and is calculated as the inverse of partial associations between nodes.
The notion of closeness is that the stronger a partial correlation between two nodes, the
quicker the influence of one node on the other may occur. Betweenness refers to the extent to
which a node is an intermediary in the shortest path from one node to another. In instances
where two nodes are not directly related (i.e., there is no edge linking them), any influence of
one node on the other is necessarily engaged via other bridging nodes, in a similar fashion to
indirect effects in mediation. However, it is also worth noting that two nodes may be directly
related and yet the shortest path between them may still be a mediated one. This is likely
when the direct link is relatively weak, and the bridging node has stronger associations to
both of these nodes.
4.3 Results
4.3.1 Sample characteristics
The final sample comprised of 98 females (58%) with a mean age of 50.85 years (24
to 80 years) and 71 males (42%) with a mean age of 48.39 years (26 to 71 years). Of the
participants included in this study, 66.9% were Australian born. Fifty-six percent were
married, 19.5% were single, 11.3% were separated or divorced, 4.7% were in a de-facto
relationship, and 1.8% were widowed.
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Chronic pain conditions varied considerably among participants. For this reason, and
for ease of interpretation, they have been categorised according to participants’ primary pain
complaint, as follows: 87.6% reported general musculoskeletal pain (e.g., back, limbs), 8.3%
widespread pain (e.g., fibromyalgia), 2.4% specific whiplash pain, and 1.8% headache.
Among the participants in this sample, 56.2% (n=95) had pain at three or more locations,
26.6% (n=45) had pain at two locations, and 17.2% (n=29) had pain at a single location.
Fifty five percent (n=94) of participants acquired chronic pain in the past 0-5 years, 21.3%
(n=36) in the past 5-10 years, 14.8% (n=25) in the past 10+ years, and 8.3% (n=14) did not
specify a pain onset date.
4.3.2 Severity of depression and anxiety symptoms
Descriptive statistics and correlations are presented in Table 4. Means and standard
deviations for the depression (M = 10.31; SD = 6.46) and anxiety (M = 5.82; SD = 5.82)
scales of the DASS-21 both represent moderately severe levels, which is similar to what has
been reported in previous studies using clinical samples (e.g., Wood et al., 2010). On
average, scores on pain intensity, perceived disability, and fear avoidance were high, whereas
scores on perceived control and pain-related self-efficacy were low, suggesting high levels of
pain for the sample, coupled with belief that pain symptoms were overwhelming, debilitating,
and beyond the patient’s control.
As shown in Table 4, depressive and anxiety symptoms were strongly correlated.
Both variables were also significantly associated with all of the pain-related beliefs
(perceived disability, pain self-efficacy, fear avoidance, and perceived control) and pain
intensity, with magnitude of association ranging from small to large. There was also
substantial inter-relation among the pain-related beliefs.
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Table 4. Means, standard deviations and inter-correlations among pain-related factors
implicated in depression and anxiety
1 2 3 4 5 6 7
1. Depression 1 .75** .28** .42** -.48** .62** -.48**
2. Anxiety 1 .25** .35** -.40** .49** -.36**
3. Pain intensity 1 .37** -.36** .26** -.26**
4. Perceived disability 1 -.64** .47** -.35**
5. Pain self-efficacy 1 -.45** .47**
6. Fear-avoidance beliefs 1 -.45**
7. Perceived control 1
M 10.3 7.2 8.8 43.8 20.3 45.7 1.6
SD 6.5 5.8 1.1 9.5 11.0 9.3 .8
Range of scores 0-21 0-21 5-10 15-60 0-55 20-68 0-3.8
α = Cronbach’s Alpha (Scale reliability), ** Correlation is significant at the 0.01 level
4.3.3 Network analyses
Figure 6 shows the network map (left-hand side) and associated centrality statistics
(right-hand side). The network map shows that, controlling for other variables in the model,
pain intensity and the affective disorder symptoms (anxiety and depression) were not directly
linked. Fear avoidance, perceived control, and self-efficacy retained direct links to depressive
symptoms, whereas perceived disability and self-efficacy were directly linked to pain
intensity. With the exception of depressive symptoms, none of the modelled variables directly
linked to anxiety.
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Figure 6. Network map (left-hand side) and associated plot of centrality measures (right-
hand side) for modelled variables
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The centrality measures indicated that there was not a single variable in the model that was
highest across all three measures (betweenness, closeness, and strength), although several of
the variables were clearly more influential than the others. Depression had the highest
strength value – attributable in part to a strong association with anxiety (see Appendix F for
network model with anxiety excluded). It also had relatively high (although not highest)
levels of betweenness, serving as the shortest (and only) path to anxiety for other variables in
the model. Depression also had a moderate closeness value, reflected by its close proximity to
several variables in the model. Perceived disability and fear avoidance were involved in the
shortest paths to other variables in the model, both as a bridging variable (highest
betweenness values) and as direct links to these variables (closeness values). Finally,
although pain self-efficacy had a relatively low betweenness value, it had a reasonably high
closeness value, due to its direct association with four other variables in the model.
4.4 Discussion
A variety of psychological constructs have been identified as potential mediators of
the relationship between affective disorder symptoms and experience of pain among chronic
pain patients, including fear avoidance, pain-related self-efficacy, locus of control, and
perceived level of disability (Fisher & Johnston, 1998; Menezes Costa et al., 2011; Miró,
Martínez, Sánchez, Prados, & Medina, 2011; Pincus & Williams, 1999; Rudy, Kerns, &
Turk, 1988). However, evidence also suggests considerable overlap between these constructs
(Baird & Sheffield, 2016; Denison et al., 2004; Keefe et al., 2004; Woby, Urmston, &
Watson, 2007), and potential bi-directional flow of effects among them (Holmes, Christelis,
& Arnold, 2013: Leeuw et al., 2007), complicating efforts to ascertain which of these
psychological mechanisms may be most influential in explaining the link between affective
symptoms and pain experience. The present study utilised an innovative analytic technique
(network analysis) to gain further insights into the inter-relationships among these
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psychological variables and pain symptoms. These insights and their implications for theory
and treatment are detailed below.
First, although affective disorder symptoms (anxiety and depression) and pain
intensity were significantly related in a bivariate context – consistent with prior studies (e.g.,
Alschuler, Theisen-Goodvich, Haig, & Geisser, 2008; Ryan & McGuire, 2016; Tayer,
Nicassio, Radojevic, & Krall, 1996) – there was a lack of direct association between affective
disorder and pain symptoms in the generated network map. This supports the notion that
these relationships may be accounted for by the proposed psychological mediators in the
model. It may also indicate that intensity of pain experience and affective disorders are better
accounted for by these psychological factors (especially the ones that showed direct links in
the network model) than each other. Indeed, prior studies that have tested the mediating
influence of psychological factors for the relationship between pain intensity and affective
disorder symptoms have found that evidence of full mediation (that is, the direct effect is
non-significant after controlling for indirect, mediating effects) (e.g., Meredith, Strong, &
Feeney, 2006; Miró et al., 2011; Rudy et al., 1988). Clinically, the lack of direct association
between these factors is somewhat unsurprising. Multidisciplinary pain management
programs (MPMP) generally target shifting patients’ unhelpful pain-related beliefs,
improving physical strength and functional capacity, and improving psychological symptoms
- as opposed to actively trying to change pain intensity ratings. Prior research suggests that
these factors are modifiable during a MPMP, whereas pain intensity ratings may or may not
shift following a pain management program.
Second, aside from a connection between depressive and anxiety symptoms in
relation to one’s pain experience in the network model, anxiety was not directly related to any
other constructs in the psychological network of pain experience. This may be partially
explained by the strong correlation found between anxiety and depressive symptoms.
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However, it should also be noted that the relationships with psychological factors and pain
experience were consistently weaker for anxiety than for depressive symptoms. One possible
explanation for this is the DASS-21 anxiety measure may be more heavily
influenced/confounded with co-morbid medical conditions and medication side effects than
the depression measure (i.e. 4 of the 7 items including dry mouth, breathing difficulty, racing
heart and trembling hands).
Third, the centrality measures suggest that self-efficacy, perceived disability, and fear
avoidance may be particularly influential for both pain intensity and affective disorder
symptoms, but in potentially different ways. Fear avoidance and perceived disability had both
the highest betweenness values (indicating that they were on the shortest path linking several
other variables in the model) and closeness values (indicating potentially stronger partial
correlations with other variables in the model). However, whereas fear avoidance was
directly linked to depressive symptoms and perceived control, perceived disability directly
linked to pain intensity and self-efficacy. Their range of associations with other modelled
variables, as well as their betweenness values suggesting that they serve as bridging
variables, indicate that these may be suitable candidates for longitudinal investigation as
potential risk factors for development and maintenance of affective disorder and intensity of
pain symptoms. The finding that fear avoidance and perceived disability seem to link directly
to different variables from each other suggests that both constructs may warrant further
attention, and may be expected to behave differently in relation to affective disorder and pain
intensity of pain symptoms.
While pain self-efficacy had a low betweenness value, it had moderately high
closeness and strength values, and a diffuse range of direct links to other constructs in the
network map. Such a pattern suggests that, while it is not the only link to any of these
modelled variables, it has some sizable direct associations with them that remain after
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136
controlling for other noted predictors. Although the cross-sectional nature of these data
preclude firm conclusions about causality or direction of effects, when viewed in conjunction
with prior longitudinal findings of self-efficacy influencing these other variables (Jackson et
al., 2014; Menez Costa et al., 2011), present findings highlight the influence of self-efficacy
in this network. This suggests that treatments that seek to bolster pain-related self-efficacy
may have benefits for multiple other symptoms in the network. In other words, increasing
self-efficacy for pain self-management is likely to have multiple beneficial impacts on the
persistent pain sufferer, and is therefore a common goal set with persistent pain sufferers
participating in MPMPs.
Finally, although perceived control had direct links to other variables in the model, it
had a low betweenness value, indicating that it is not the most expedient way to link one
variable to another. For instance, fear avoidance appears to function as a stronger bridge to
depression, and perceived disability is a stronger link to pain-related self-efficacy. Thus,
while the present findings do not completely discount the possibility that perceived control
acts as an influence (direct or as a mediator) on other modelled constructs, it is clear that
other proposed predictors and mediators in the model are more important. Consequently,
these findings suggest that if one were to prioritise future research into pain experience or
affective disorder symptoms, it may be more useful to start with these other proposed risk
factors.
Clinically, it makes sense that fear-avoidance and depression are directly linked. Avoidance
of feared situations is likely to result in reductions in socialisation, functional capacity,
enjoyable activities and purposeful/meaningful activities; and hence, result in the
development of poorer self-perception. In fact, changing these behaviours is one of the main
aims of MPMPs, and behavioural and cognitive therapies for depression and persistent pain.
It also makes sense clinically, that perceived disability and self-efficacy are closely linked.
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Having a low degree of confidence in ones’ ability to manage their own pain is
understandably associated with feeling more disabled by that pain, and conversely, feeling
more able to manage their pain across various situations is associated with feeling more able
despite the pain. However, to be able to manage ones’ pain does not necessarily mean to be
able to control it. Another major tenant of MPMPs and cognitive-behavioural therapies for
persistent pain, is to assist the sufferer to learn about their pain, to learn to control what they
can, and to accept and adapt to what they cannot control (e.g. through flare up management,
pacing training, adapting the environment, cognitive therapy and mindfulness training).
4.4.1 Limitations
A number of limitations to the current research should be considered. Firstly, this
study was cross-sectional and the positive associations found do not permit any causal
inferences to be made. It is thus possible that the variables identified as influential in the
network analysis co-occur because they have a shared, generic common cause with a wide
range of modelled variables. However, if such an explanation holds true, then the partial
correlation nature of this analysis suggests that the underlying third variable is not among
those modelled in the present study. An alternative explanation for the present results is that
these influential variables may instead be a common outcome for these variables. Further
testing, with a longitudinal network map, may help to disentangle direction of effects, whilst
maintaining the advantages of network analysis (e.g., its focus on the aggregate influence of a
variable in the whole model rather than for a single outcome).
Secondly, self-report is considered the gold standard of pain measurement given its
consistency with the ‘subjective’ definition of pain (Pautex et al., 2007). However, limitations
are inherent in the subjective nature of self-reported measures, such as ability to discern and
effectively communicate one’s pain state. It is thus reassuring that the present sample
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comprises chronic pain patients whose symptoms were evaluated by a multi-disciplinary
team involved in their treatment planning and implementation.
Thirdly, given that the majority of pain localisations included in this study were
musculoskeletal in nature, it might be concluded that these findings lack generalizability to
other pain locations. This issue of generalizability may be of particular concern if certain
beliefs are found to be more common among individuals with specific pain localisations. For
example, fear-avoidance beliefs have been shown to be the most important psychosocial
predictor of disability among patients with chronic low back pain (CLBP; Lethem et al.,
1983; Brox et al., 2005). Thus, interpretation of the relationships supported in this study may
be limited to similar samples of chronic pain patients.
4.4.2 Conclusion
Despite these limitations, the present study offers several key insights into the nature
of the relationship between pain intensity and affective disorders. It showed that a direct
relationship between these variables disappears once controlling for proposed psychological
mediators. Further, despite observed inter-relations among the psychological factors, self-
efficacy, fear avoidance, and perceived disability were each identified as having influence in
the network model. Whereas self-efficacy tended to have more direct associations with other
variables, both fear avoidance and perceived disability often served as links between other
variables, and may thus be best conceptualised as mediators that explain the inter-relations of
other symptoms in this network. Longitudinal investigation in which these variables are
manipulated are needed to confirm or disconfirm predictions about the nature and direction of
their influence on the other constructs in the presently tested network. A greater
understanding of the implications of unhelpful pain-related cognitions is needed to improve
the efficacy of treatment programs and associated outcomes for chronic pain sufferers.
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References
Allaz, A.F., & Cedraschi, C. (2015). Emotional aspects of chronic pain (pp.21-34). In
Pickering & Gibson (Eds), Pain, Emotions and Cognition: A complex nexus.
Switzerland: Springer International.
Alschuler, K N., Theisen-Goodvich, M E., Haig, A J., & Geisser, M E. (2008). A comparison
of the relationship between depression, perceived disability, and physical performance
in persons with chronic pain. European Journal of Pain, 12, 757-764. DOI:
10.1016/j.ejpain.2007.11.003
Asmundson, G J G., Norton, G R., & Allerdings, M D. (1997). Fear and avoidance in
dysfunctional chronic back pain patients. Pain, 69(3), 231-236. DOI:
10.1016/S03043959(96)03288-5
Arraras, J I., Wright, S J., Jusue, G., Tejedor, M., & Calvo, J I. (2002). Coping style, locus of
control, psychological distress and pain-related behaviours in cancer and other diseases.
Psychology, Health & Medicine, 7(2), 181-197. DOI: 10.1080/13548500120116139
Bair, M J., Robinson, R L., Katon, W., & Kroenke, K. (2003). Depression and
paincomorbidity: a literature review. Archives of Internal Medicine, 163, 2433–45.
DOI: 10.1001/archinte.163.20.2433
Bair, M J., Wu J., Damush, T M., Sutherland, J M., & Kroenke, K. (2008). Association of
depression and anxiety alone and in combination with chronic musculoskeletal pain in
primary care patients. Psychosomatic Medicine, 70(8), 890-897. DOI:
10.1097/PSY.0b013e318185c510
Baird, A., & Sheffield, D. (2016). The relationship between pain beliefs and physical and
mental health outcome measures in chronic low back pain: Direct and indirect effects.
Healthcare, 4, 58-68. DOI: 10.3390/healthcare4030058
![Page 154: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/154.jpg)
140
Baker, T A., Buchanan, N T., & Corson, N. (2008). Factors influencing chronic pain intensity
in older black women: examining depression, locus of control, andphysical health.
Journal of Women’s Health, 17, 869-878. DOI: 10.1089/jwh.2007.0452
Bandura, A., Pastorelli, C., Barbaranelli, C., & Caprara, G V. (1999). Self-efficacy pathways
to childhood depression. Journal of Personality and Social Psychology,76(2), 258-269.
Beck, A.T. (1976). Cognitive therapy and the emotional disorders. New York, NY: Meridian.
Beck, A.T., Emery, G., & Greenberg, R. (1985). Anxiety disorders and phobias: A cognitive
perspective. New York, NY: Basic Books.
Beesdo, K., Jacobi, F., Hoyer, J., Low, N C P., Höfler, M., & Wittchen, H. (2010).
Painassociated with specific anxiety and depressive disorders in a nationally
representativepopulation sample. Social Psychiatry Epidemiology, 45, 89-104. DOI:
10.1007/s00127-009-0045-1
Blyth, F.M., March, L.M., Nicholas, M.K., & Cousins, M.J. (2005). Self-management of
chronic pain: A population-based study. Pain, 113(3), 285-292. DOI:
10.1016/j.pain.2004.12.004
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006). Survey of
chronic pain in Europe: Prevalence, impact on daily life, and treatment. European
Journal of Pain,10, 287-333. DOI: 10.1016/j.ejpain.2005.06.009
Brox, J I., Storheim, K., Holm, I., Friis A., & Reikerâs, O. (2005). Disability, pain,
psychological factors and physical performance in healthy controls, patients with sub-
acute and chronic low back pain: A case control study. Journal of Rehabilitation
Medicine, 37, 95-99. DOI: 10.1080/16501970410017738
Buhrman, M., Nilsson-Ihrfelt, E., Jannert, M., Ström, L., & Andersson, G. (2011). Guided
internet-based cognitive behavioural treatment for chronic back pain reduces pain
![Page 155: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/155.jpg)
141
catastrophizing: A randomized controlled trial. Journal of Rehabilitation Medicine, 43,
500-505. DOI: 10.2340/16501977-0805
Butler, D., & Moseley, L. (2013). Explain pain. (2nd ed.). South Australia, Australia:
Noigroup Publications.
Campbell, L.C., Clauw, D.J., & Keefe, F.J. (2003). Persistent pain and depression: A
biopsychosocial perspective. Biological Psychiatry, 54, 399-409. DOI: 10.1016/S0006-
3223(03)00545-6
Carpino, E., Segal, S., Logan, D., Lebel, A., & Simons, L. E. (2014). The interplay of pain-
related self-efficacy and fear on functional outcomes among youth with headache. The
Journal of Pain, 15(5), 527-534. DOI: 10.1016/j.jpain.2014.01.493
Ciechanowski, P., Sullivan, M., Jensen, M., Romano, J., & Summers, H. (2003). The
relationship of attachment style to depression, catastrophizing and health care
utilization in patients with chronic pain, Pain, 104(3), 627-637.
Costantini, G., Epskamp, S., Borsboom, D., Perugini, M., Móttus, R., Waldorp, L.J., et al.
(2015). State of the aRt personality research: A tutorial on network analysis of
personality data in R. Journal of Research in Personality, 54, 13-29. DOI:
10.1016/j.jrp.2014.07.003
Crombez, G., Eccleston, C., Van Damme, S., Vlaeyen, J W S., & Karoly, P. (2012). The fear
avoidance model of chronic pain: The next generation. Clinical Journal of Pain, 28(6),
475-483. DOI: 10.1097/AJP.0b013e2182385392
Cross, M J., March, L M., Lapsley, H M., Byrne, E., & Brooks, P M. (2006). Patient self-
efficacy and health locus of control: relationships with health status and arthritis-related
expenditure. Rheumatology, 45(1), 92-96. DOI: 10.1093/rheumatology/kei114
Currie, S R., & Wang J. (2004). Chronic back pain and major depression in the general
Canadian population. Pain, 107, 54-60.
![Page 156: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/156.jpg)
142
Demyttenaere, K., Bruffaerts, R., Lee, S., Posada-Villa, J., Kovess, V., Angermeyer, M.C., et
al. (2007). Mental disorders among persons with chronic back or neck pain: Results
from the world mental health surveys. Pain, 129, 332-342. DOI:
10.1016/j.pain/2007.01.022
Denison, E., Ǻsenlӧf, P., & Lindberg, P. (2004). Self-efficacy, fear-avoidance, and
painintensity as predictors of disability in subacute and chronic musculoskeletal
painpatients in primary health care. Pain, 111, 245-252. DOI:
10.1016/j.pain.2004.07.001
Denison, E., Ǻsenlӧf, P., Sandborgh, M., & Lindberg, P. (2007). Musculoskeletal pain in
primary health care: Subgroups based on pain intensity, disability, self-efficacy, and
fear-avoidance variables. Journal of Pain, 8(1), 67-74. DOI:
10.1016/j.jpain.2006.06.007
Edwards, R.R., Smith, M.T., Klick, B., Magyar-Russell, G., Haythornthwaite, J.A.,
Holavanahalli, R., et al. (2007). Symptoms of depression and anxiety as unique
predictors of pain-related outcomes following burn injury. Annals of Behavioral
Medicine, 34(3), 313-322. DOI: 10.1080/08836610701677725
Feuerstein, M., & Thebarge, R W. (1991). Perceptions of disability and occupational stress as
discriminators of work disability in patients with chronic pain. Journal of Occupational
Rehabilitation, 1(3), 185-195. DOI: 10.1007/BF01073455
Field, A. (2009). Discovering Statistics Using SPSS (3rd ed), Sage, Thousand Oakes,
California.
Fisher, K., & Johnston, M. (1998). Emotional distress and control cognition as predictors of
the impact of chronic pain on disability. British Journal of Health Psychology, 3(3),
225-236. DOI: 10.1111/j.2044-8287.1998.tb00569.x
![Page 157: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/157.jpg)
143
Fordyce, W E., Roberts, A H., & Sternbach, R A. (1985). The behavioural management of
chronic pain: A response to critics. Pain, 22(2), 113-125.
Fransen, M., Woodward, M., Norton, R., Coggan, C., Dawe, M., & Sheridan, N. (2002). Risk
factors associated with the transition from acute to chronic occupational back pain.
Spine, 27(1), 92-98. DOI: 10.1097/00007632-200201010-00022
French, D J., Holroyd, K A., Pinell, C., Malinoski, P T., O’Donnell, F., & Hill, K R. (2000).
Perceived self-efficacy and headache-related disability. Journal of Head and Face Pain,
40(8), 647-656. DOI: 10.1046/j.1526-4610.2000.040008647.x
Gallagher, R M., & Verma, S. (1999). Managing pain and comorbid depression: A public
health challenge. Seminars in Clinical Neuropsychiatry, 4, 203–20.
Gatchel, R J., Peng, Y B., Peters, M L., Fuchs, P N., & Turk, D C. (2007).
Thebiopsychosocial approach to chronic pain: Scientific advances and future directions.
Psychological Bulletin, 133(4), 581-624. DOI: 10.1037/0033-2909.133.4.581
Gerrits MM, van Oppen P, Van Marwijk HW, Penninx BW, van der Horst HE. (2014). Pain
and the onset of depressive and anxiety disorders. Pain, 155, 53–9. DOI:
10.1016/j.pain.2013.09.005
Gerrits, M.M.J.G., van Marwijk, H.W.J., van Oppen, P., van der Horst, H., & Penninx,
B.W.J.H. (2015). Longitudinal association between pain, and depression and anxiety
over four years. Journal of Psychosomatic Research, 78, 64-70. DOI:
10.1016/j.jpsychores.2014.10.011
Guzmán, J., Esmail, R., Karjalainen, K., Malmivaara, A., Irvin, E., & Bombardier, C. (2001).
Multidisciplinary rehabilitation for chronic low back pain: systematic review. British
Medical Journal, 322(7301), 1511-1516.
Hansen, G R., & Streltzer, J. (2005). The psychology of pain. Emergency Medicine Clinics of
North America, 23, 339-348.
![Page 158: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/158.jpg)
144
Hasenbring, M I., & Verbunt, J A. (2010). Fear-avoidance and endurance-related responses to
pain: New models of behaviour and their consequences for clinical practice. Clinical
Journal of Pain, 29(9), 747-753. DOI: 10.1097/AJP.0b013e3181e104f2
Heath, R L., Saliba, M., Mahmassani, O., Major, S C., & Khoury, B A. (2008). Locus of
control moderate the relationship between headache pain and depression. Journal of
Headache Pain, 9, 301-308. DOI: 10.1007/s10194-008-0055-5
Hechler, T., Dobe, M., Damschen, U., Blakenburg, M., Schroeder, S., Kosfelder, J., et al.
(2010). The pain provocation technique for adolescents withchronic pain: Preliminary
evidence for its effectiveness. Pain Medicine, 11(6), 897-910. DOI: 10.111/j.1526-
4637.2010.00839.x
Henry, J D., & Crawford, J R. (2005). The short-form version of the depression anxiety stress
scales (DASS-21): Construct validity and normative data in a large non-clinical sample.
British Journal of Clinical Psychology, 44, 227-239. DOI: 10.1348/014466505X29657
Holmes, A., Christelis, N., & Arnold, C. (2013). Depression and clinical pain. Medical
Journal of Australia, 199(6 Suppl), S17-S20. DOI: 10.5694/mja12.10589
Innes, S I. (2005). Psychosocial factors and their role in chronic pain: a brief review of
development and current status. Chiropractic and Osteopathy, 13(6), 1-4. DOI:
10.1186/1746-1340-13-6
Jackson, T., Wang, Y., Wang, Y., & Fan, H. (2014). Self-efficacy and chronic pain outcomes:
A meta-analytic review. The Journal of Pain, 15(8), 800-814. DOI:
10.1016/j.jpain.2014.05.002
Jensen, M.P., & Karoly, P. (1991). Control beliefs, coping efforts, and adjustment to chronic
pain. Journal of Consulting and Clinical Psychology, 59(3), 431-438.
![Page 159: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/159.jpg)
145
Keefe, F.J., Rumble, M.E., Scipio, C.D., Giordano, L.A., & Perri, L.M. (2004). Psychological
aspects of persistent pain: Current state of the science. The Journal of Pain, 5(4), 195-
211. DOI: 10.1016/j.jpain.2004.02.576
Krämer, N., Schäfer, J., & Boulesteix, A.-L. (2009). Regularized estimation of large-scale
gene association networks using graphical Gaussian models. BMC Bioinformatics, 10,
384. DOI: 10.1186/1471-2105-10-384
Kroenke, K., Wu, J., Bair, M. J., Krebs, E. E., Damush, T. M., & Tu, W. (2011). Reciprocal
relationship between pain and depression: a 12-month longitudinal analysis in primary
care. The Journal of Pain, 12(9), 964-973. DOI: 10.1016/j.jpain.2011.03.003
Lau-Walker, M. (2006). A conceptual care model for individualized care approach in cardiac
rehabilitation – combining both illness representation and self-efficacy. British Journal
of Health Psychology, 11(1), 103-117. DOI: 10.1348/135910705X41914
Leeuw, M., Goossens, M E J B., Linton, S J., Crombez, G., Boersma, K., & Vlaeyen, J.W.S.
(2007). The fear-avoidance model of musculoskeletal pain: Current state of scientific
evidence. Journal of Behavioral Medicine, 30(1), 77-94. DOI: 10.1007/s10865-
0069085-0
Lethem, J., Slade P D., Troup, J D., & Bentley, G. (1983). Outline of a fear-avoidance
modelof exaggerated pain perception – I. Behaviour Research and Therapy, 21, 401-
408.
Lovibond, P F., & Lovibond, S H. (1995). The structure of negative emotional states:
Comparison of the depression anxiety stress scales (DASS) with the Beck depression
and anxiety inventories. Behaviour Research and Therapy, 33(3), 335-343.
Means-Christensen, A.J., Roy-Byrne, P.P., Sherbourne, C.D., Craske, M.G., & Stein, M.B.
(2008). Relationships among pain, anxiety, and depression in primary care. Depression
and Anxiety, 25(7), 593-600. DOI: 10.1002/da.20342
![Page 160: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/160.jpg)
146
Menezes Costa, L C., Maher, C G., McAuley, J H., Hancock, M J., & Smeets, R J E M.
(2011). Self-efficacy is more important than fear of movement in mediating
therelationship between pain and disability in chronic low back pain. European Journal
of Pain, 15, 213-219. DOI: 10.1016/j.ejpain.2010.06.014
Meredith, P., Strong, J., & Feeney, J A. (2006). Adult attachment, anxiety, and pain self-
efficacy as predictors of pain intensity and disability. Pain, 123, 146-154. DOI:
10.1016/j.pain.2006.02.025
Miller, R.P., Kori, S., & Todd, D. (1991). The Tampa Scale: A measure of kinesiophobia.
Clinical Journal of Pain, 7(1), 51-52.
Miró, E., Martínez, Sánchez, A.I., Prados, G., & Medina, A. (2011). When is pain related to
emotional distress and daily functioning in fibromyalgia syndrome? The mediating
roles of self-efficacy and sleep quality. British Journal of Health Psychology, 16(4),
799-814. DOI: 10.111/j.2044-8287.2011.02016.x
Nicholas, M.K. (1989). Self-efficacy and chronic pain. Paper presented at the annual
conference of the British Psychological Society. St. Andrews.
Pautex, S., Herrmann, F., Michon, A., Giannakopoulos, P., & Gold, G. (2007). Psychometric
properties of the Doloplus-2 observational pain assessment scale and comparison to
self-assessment in hospitalized elderly. Clinical Journal of Pain, 23(9), 774-779. DOI:
10.1097/AJP.0b013e318154b6e3
Pincus, T., & Morley, S. (2001). Cognitive-processing bias in chronic pain: A review and
integration. Psychological Bulletin, 127(5), 599-617.
Ramírez-Maestre, C., Esteve, R., & López-Martínez, A. (2014). Fear-avoidance, pain
acceptance and adjustment to chronic pain: A cross-sectional study on a sample of 686
patients with chronic spinal pain. Annals of Behavioral Medicine, 48(3), 402-410. DOI:
10.1007/s12160-014-9619-6
![Page 161: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/161.jpg)
147
Pfingsten, M., Leibing, E., Harter, W., Kröner-Herwig, B., Hempel, D., Kronshage, U., et al..
(2001). Fear-avoidance behaviour and anticipation of pain in patients with chronic low
back pain: A randomized controlled study. Pain Medicine, 2(4), 259-266. DOI:
10.1046/j.1526-4637.2001.01044.x
Pincus, T., & Williams, A. (1999). Models and measurement of depression in chronic pain.
Journal of Psychosomatic Research, 47(3), 211-219. DOI:
10.1016/S00223999(99)00045-8
Rudy, T E., Kerns, R D., & Turk, D C. (1988). Chronic pain and depression: Toward
acognitive-behavioral mediation model. Pain, 35(2), 129-140.
Ryan, S., & McGuire, B. (2016). Psychological predictors of pain severity, pain interference,
depression, and anxiety in rheumatoid arthritis patients with chronic pain. British
Journal of Health Psychology, 21, 336-350. DOI: 10.1111/bjhp.12171
Swinkels-Meewisse, I E J., Roelofs, J., Verbeek, A L M., Oostendorp, R A B., & Vlaeyen, J
W S. (2003). Fear of movement/(re)injury, disability and participation in acute low
back pain. Pain, 105, 371-379.
Tayer, W.G., Nicassio, P.M., Radojevic, V., & Krall, T. (1996). Pain and helplessness as
correlates of depression in systemic lupus erythematosus. British Journal of Health
Psychology, 1(3), 253-262. DOI: 10.1111/j.2044-8287.1996.tb00507.x
Woby, S R., Urmston, M., & Watson, P J. (2007). Self-efficacy mediates the relation between
pain-related fear and outcome in chronic low back pain patients. European Journal of
Pain, 11(7), 711-718. DOI: 10.1016/j.ejpain.2006.10.009
![Page 162: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/162.jpg)
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Chapter 5
Study Three: Post-intervention treatment adherence for chronic pain patients may
depend on psychological factors2
Emma Thompson1, Jaclyn Broadent1, Matthew Fuller-Tyszkiewicz1, Melanie Bertino1,2 and
Petra Staiger1
1 School of Psychology, Deakin University, Burwood
2 The Victorian Rehabilitation Centre
Word Count: 5,141; no. of references: 35; no. of tables: 2; no. of figures: 1
Declaration of interest: The authors report no conflicts of interest or financial disclosures.
The authors alone are responsible for the content and writing of the paper.
Correspondence:
Dr Jaclyn Broadbent
Deakin University, School of Psychology
221 Burwood Hwy, Burwood, Victoria, Australia 3125
Email: [email protected]
Phone: +61 3 92443043
Fax: +61 3 92446858
2 This paper is currently under review for publication to the journal, Clinical Psychologist.
Clinical Psychologist have specific guidelines for structure, formatting and referencing. This
paper was prepared in accordance with those guidelines
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Abstract
Objectives: The present study evaluated the influence of psychological factors (anxiety,
depression, fear avoidance, and self-efficacy) in predicting patient adherence to their
personalised post-intervention treatment maintenance plan for the interval between discharge
from an out-patient treatment and follow-up at 3-6 months.
Design and Method: Participants included sixty-one chronic pain patients aged 31 to 72
years (M = 54.28, SD = 10.32) who had completed a pain management program between
2014 and 2016 at a rehabilitation centre. Participants completed the psychological measures
at pre-intervention into the pain management program and at the completion of the program;
and a measure of treatment maintenance adherence at 3-6 months post-intervention to
measure compliance with the post-discharge treatment plan. The psychological variables at
both timepoints were included in regression models to determine whether pre- or post-
intervention scores predict adherence, and whether these effects are dependent on how much
these symptoms change during the intervention phase.
Results: Hierarchical regression analyses showed that 28% variance in post-intervention
adherence to post-intervention treatment maintenance plans was accounted for by the
predictors. Fear avoidance and depressive symptoms (both at post-intervention) made
significant unique contributions to prediction. Moderation analyses showed that individuals
with initially low levels of anxiety, whose symptom severity worsened during the
intervention phase, were more likely to adhere to the post-discharge treatment plan.
Conclusions: This pattern of findings shows relevance for psychological factors in treatment
adherence. Nevertheless, questions remain about the nature of their influence on adherence,
and clinical and research implications are discussed in this light.
Key words: Self-Efficacy; Fear-avoidance; Depression; Anxiety; Pain treatment adherence
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5.1 Introduction
The burden of chronic pain is exacerbated by poorly managed presentations, frequent
hospital admissions, and the need for patients to attend multiple treatment programmes
(Imani & Safari, 2011). Between 25 and 50 percent of patients who receive treatment are
non-adherent to treatment recommendations (Roebuck, Liberman, Gemmill-Toyama, &
Brennan, 2011). This non-adherence may be viewed along a continuum, ranging from
complete non-adherence to perfect adherence to a treatment plan. As such, non-adherence can
be quantified both in terms of the level of adherence along that continuum, and the forms of
non-adherence, such as missing appointments or treatment sessions, not taking medications
as directed, or not following recommended lifestyle changes both during and after treatment
has terminated (Dworkin et al., 2009). Non-adherence is a significant issue, increasing the
likelihood of re-admissions to already strained programme waitlists and further contributes to
the healthcare burden (Broekmans, Dobbels, Milisen, Morlion, & Vanderschueren, 2009).
The present study limits its focus to evaluation of the role of psychological factors for
adherence in a chronic pain treatment context as these may be amenable to change.
A variety of theoretical frameworks have been used to account for the influence of
psychological factors on treatment adherence, including the Common-Sense Model of Self-
Regulation (Leventhal, Phillips, & Burns, 2016), the Health Beliefs Model (Rosenstock,
Strecher, & Becker, 1988), the Protection Motivation Theory (Maddux & Rogers, 1983), and
the Theory of Planned Behavior (Azjen, 1991). A common element for these models is the
proposed role of self-efficacy in determining the extent to which an individual initiates and
maintains a treatment regime. It is reasoned that individuals who feel confident in their ability
to undertake the treatment plan may be more motivated to invest time in the treatment, and
may be more likely to persist in the face of setbacks or initial challenges. Recent reviews by
Thompson, Broadbent, Bertino, and Staiger (2016) and Holmes, Hughes, and Morrison
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(2014) support the role of self-efficacy as a consistent predictor of treatment adherence.
These reviews demonstrate the potential robustness of self-efficacy’s effect on adherence as it
was found to be a significant unique predictor across models with differing combinations of
predictors, and across different stages of treatment.
Severity of the patient’s symptoms may also be reasoned to impact treatment
adherence (Leventhal et al., 2016; Maddux & Rogers, 1983). On the one hand, perceptions
regarding the severity of one’s condition and the likelihood of sustained or worsening
symptoms into the future may motivate an individual to seek treatment (Milne, Sheeran, &
Orbell, 2000). On the other hand, the nature of one’s condition (including co-morbidities)
may reduce the treatment options or the likelihood of recovery. For instance, affective
disorders such as depression and anxiety, which are commonly present in chronic pain
populations (Demyttenaere et al., 2007), may both exacerbate pain symptoms and influence
one’s willingness to adhere to treatment plans due to reduced quality of life, impaired
cognitive focus, feelings of hopelessness, and loss of energy and motivation (Cipher,
Fernandez, & Clifford, 2002; Ferreira & Pereira, 2014; Gormsen, Rosenberg, Bach & Jensen,
2010; Orenius et al., 2012). Similarly, a review by Wertli, Rasmussen-Barr, Weiser,
Bachmann, and Brunner (2014) found high fear-avoidance beliefs to be associated with poor
treatment outcomes (including low treatment adherence) in patients with chronic low back
pain. The authors reasoned that fear avoidance beliefs may entail focusing on the worst
possible outcomes (pain catastrophizing) of one’s condition and that this, in turn, encourages
avoidance of the health condition rather than treating it directly.
Despite growing evidence of potential psychological predictors of treatment
adherence, gaps remain. First, whereas adherence during the treatment phase is a common
focus in past research, adherence to post-treatment plans is less consistently evaluated
(Thompson et al., 2016). While it is important to identify predictors of success during this
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phase, in many instances chronic pain patients are recommended ongoing physical and
cognitive exercises post-intervention to maintain or further enhance treatment effects.
Contact with a healthcare professional post-intervention is likely to be far less frequent and,
as such, there is greater reliance upon the patient to self-manage their post-intervention
treatment plan. Accordingly, these psychological predictors may become more relevant
during this latter phase. Second, the bulk of prior research into the predictors of adherence
has employed cross-sectional designs (Holmes et al., 2014). Leventhal et al. (2016)
emphasize that treatment adherence is likely to be a dynamic process, and the predictors may
change over the course of one’s treatment plan. For instance, self-efficacy may be a focus of
treatment and, hence, an individual’s low level of self-efficacy pre-treatment may be less
predictive of their overall adherence than later in the treatment, once self-efficacy levels have
improved. Thus, timing of measurement and ability to monitor change in these predictors
may impact results obtained.
The theories and empirical evidence detailed above identified the potential influence
of symptom severity (including co-morbid conditions, such as depression, anxiety, and fear
avoidance tendencies) and self-efficacy as key drivers of treatment adherence during the
intervention phase. The present study builds upon this prior research by exploring, using a
prospective design, whether these psychological factors are predictive of adherence post-
intervention (i.e., between discharge and a 3-6 month follow-up session) for a sample of
chronic pain sufferers. We explored adherence in terms of extent to which a prescribed
treatment plan was followed, acknowledging that a binary adherence/non-adherence decision
would likely miss this variability. Further, given the dynamic nature of these predictors
(Leventhal et al., 2016), the predictive value of these psychological variables were tested by
regressing post-intervention level of adherence to prescribed treatment plan onto scores on
these psychological variables collected at baseline (pre-intervention) as well as post-
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intervention. Measurement times were limited to pre- and post-intervention as, in many
settings, at least some of the proposed predictors are measured at these times as part of
routine care. As such, findings of predictive value at these time-points would allow for rapid
translation into practice.
On the basis of prior research findings and arguments proposed above, it was
hypothesised that:
1. Adherence post-intervention follow-up would be lower for individuals with higher
depression, anxiety, and fear avoidance tendencies, and lower self-efficacy at pre-
intervention (Hypothesis 1) and post-intervention (Hypothesis 2).
2. Given their greater proximity to the outcome variable (post-intervention adherence),
post-intervention levels of these risk factors would be better predictors than their pre-
intervention levels for predicting adherence in the post-intervention phase
(Hypothesis 3).
3. Hypothesis 3 is premised on the notion that scores on these predictors might change
over the course of treatment and, accordingly, scores measured closer to measurement
of the outcome variable would have higher predictive value. To test this further, we
hypothesized that:
4. The predictive value of baseline levels scores on the psychological factors on post-
intervention adherence would be moderated by magnitude of change in these
psychological variables from baseline to post-intervention (Hypothesis 4).
Specifically, it was predicted that these baseline scores would be stronger predictors
of post-intervention adherence for individuals who experienced limited change in
these psychological variables across the period of treatment.
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5.2 Method
5.2.1 Participants
Participants included sixty-one chronic pain out-patients between 31 to 72 years of
age (M = 54.28, SD = 10.32) who had completed a pain management program between 2014
and 2016 at a rehabilitation centre in Victoria, Australia. Entry into the treatment program
was based on an intake assessment conducted by a multidisciplinary team comprising a pain
specialist physician, occupational therapist, registered psychologist, and physiotherapist.
Diagnosis was based on the presenting symptoms via subjective report in addition to
physical, psychological, and functional examinations. The majority of participants who
participated in the current study experienced musculoskeletal pain in three or more locations
(n=39, 64.8%) for approximately five or less years. Participants were predominantly male (n
= 36, 59%), born in Australia (n= 44, 72.3%), and married (n=26, 43%).
G*Power version 3.1 (Faul, Erdfelder, Buchner, & Lang, 2009) was used to calculate
power for the current sample. Based on the sample size of 61 and setting alpha at .05 (two-
tailed) and power at .80, the current sample was sufficiently powered to detect the
contribution of an individual predictor in a regression model with effect size of sr2 = .12 or
greater. For paired samples t-test comparisons of scores on a variable over time, the sample
of 61 was sufficiently powered to detect a Cohen’s d of .36 or greater. According to
Ferguson’s (2009) guidelines, the present sample size is sufficient to detect small yet
practically significant effects for social science data.
5.2.2 Treatment
The treatment programs were individually tailored to the patient goals and needs
identified during the multidisciplinary assessment. The range of length for the programs was
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between 6 and 12 weeks’ duration, 2-3 days per week for 1-4 hours per day, depending on
patient goals, needs, and individual capacity and ability to attend.
The programs were all delivered by a multidisciplinary team including a
physiotherapist (delivering land and water based therapy weekly), psychologist (all
participants had individual sessions with the psychologist weekly), and occupational therapist
(delivering weekly sessions focused on functional and vocational goals). All clinicians were
fully qualified and experienced practitioners working within a private pain clinic.
All participants received individual treatment sessions from all three disciplines, and
those who were appropriate to attend group education and relaxation sessions (no major
psychological, physical, language or intellectual barriers, not hearing impaired, etc.) were
also encouraged to attend group sessions. The group sessions included 4-6 participants in
each group, and the education topics and relaxation training sessions were delivered over a
period of 6 weeks (2-3 days per week). Those who did not attend the group sessions had this
educational content and relaxation training delivered within their individual sessions. All
participants were given a copy of the same patient manual, outlining the key concepts and
recommendations from each of the three disciplines involved in delivering the pain
management program (physiotherapist, psychologist, and occupational therapist).
5.2.3 Measures
5.2.3.1 Affective disorder symptoms
The 21-item Depression, Anxiety, and Stress Scale (DASS-21; Lovibond &
Lovibond, 1995) was used to measure depression and anxiety. Response options were
provided on a 4-point Likert-type scale (where 0 = Did not apply to me at all, and 3 =
Applied to me most of the time). Participants were asked to respond to each item in the
context of how they felt when experiencing ongoing pain over the last seven days. Total
scores range from 0 to 42, with higher scores reflecting elevated depressive or anxiety
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symptomatology. Cutoff scores of 14+ and 10+ can be used to identify participants with at
least moderate severity depression and anxiety, respectively. The DASS-21 met scale
reliability criteria for use with this sample with a Cronbach’s alpha of .90 at pre-intervention
and .93 at post-intervention.
5.2.3.2 Pain self-efficacy
The 10-item Pain Self-Efficacy Questionnaire (PSEQ; Nicholas, 1989) was used to
measure patients’ confidence in their ability to self-manage pain, including household chores,
socialising, work, and coping with pain without medication. Participants responded to items
on a 7-point, end-defined scale (0 = Not at all confident to 6 = Completely confident). Total
scores range from 0 to 60, with higher scores indicating greater confidence in managing pain.
Following guidelines included as part of the adult clinical change calculator from the
electronic Persistent Pain Outcomes Collaboration (ePPOC; Australian Health Services
Research Institute, 2017), scores on the PSEQ of less than 20 indicates severe impairment,
20-30 = moderate impairment, 31-40 = mild impairment, and > 40 = minimal impairment.
Prior studies have established strong test-retest reliability of the PSEQ (Asghari & Nicholas,
2001), and construct validity as demonstrated through correlations with other measures of
self-efficacy and pain-related disability (Kaivanto, Estlander, Moneta, & Vanharanta, 1995).
In the present study, Cronbach’s alpha was .93 at pre-intervention and .95 at post-
intervention.
5.2.3.3 Fear-avoidance beliefs
The 17-item TAMPA Scale of Kinesiophobia (TSK; Kori, Miller, & Todd, 1990) was
used to measure fear of movement or (re)injury. Participants responded to statements
regarding fear of movement on a 4-point scale (1 = strongly disagree to 4 = strongly agree).
Total scores range from 17 to 68, with higher scores indicating greater fear of movement or
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(re)injury. Cronbach’s alpha of .88 at pre-intervention and .83 at post-intervention in the
present study.
5.2.3.4 Perceived disability
The 5-item disability subscale of the Survey of Pain Attitudes (SOPA; Jensen, Karoly,
& Huger, 1987) was used to measure patient’s self-perceived disability at baseline due to
their chronic pain. Participants responded to items on a 5-point scale (0 = this very untrue for
me to 4 = this is very true for me). Total scores range from 0 to 20, with higher scores
reflecting greater perceived disability. Cronbach’s alpha was .60 at pre-intervention.
5.2.3.5 Treatment maintenance
The Treatment Maintenance Questionnaire (TMQ) was developed by the researchers
for this study to measure adherence behaviour to post-intervention recommendations (see
Appendix K for the full list of items). Development of this measure was based on the
treatment modalities received and post-intervention adherence to a range of activities
recommended during the pain program. Treatment modalities included a) physiotherapy, b)
psychology, c) occupational therapy, and d) hydrotherapy. Adherence to a range of
recommended activities specific to the pain treatment provided included five categories: a)
Regular exercise, b) Biomechanics, c) Relaxation techniques, d) Activity pacing, and e) Stress
and mood management. Activities in each category were measured on a 4-point Likert-type
scale (1 = I use this strategy not at all to 4 = I use this strategy all of the time). Participants
could also select N/A if the activity was not recommended to them. N/A responses were
scored as an average of the other scores. All activity scores were summed, with scores
ranging from 16 to 64. High scores indicate greater adherence to treatment recommendations.
The TMQ has adequate face validity (as it was created in consultation with employees at this
pain clinic, and the measure covers activities that the patients are likely to be recommended),
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and the items were shown to be internally consistent. In the present study, Cronbach’s alpha
of .87 at 3-6 months post-intervention follow-up.
5.2.4 Procedure
Relevant ethics approval was gained from the hospital and University. One hundred
and forty patients who had completed a pain management program at a pain clinic in
Victoria, Australia between 2014 and 2016 were invited to participate. Each of the 140
eligible individuals presenting for assessment at the pain clinic during this period were
invited to participate by the assessing psychologist, and were given relevant verbal and
printed information about the study. Informed consent was gained by those willing to
participate, and the optional nature of the study was emphasized, including that it would not
impact on their treatment in any way and that they were free to withdraw their consent at any
time without consequence.
Of the 140 eligible patients presenting for an assessment, sixty-one consenting
participants completed the above battery of questionnaires at: (1) pre-intervention into the
pain management program, (2) the completion of the program, and (3) 3-6 months post-
intervention. The remaining 79 invitees declined to participate.
5.2.5 Data analyses
Given the primary focus in the present study on predicting adherence, preliminary
analyses were undertaken to contextualise main analyses. First, correlational analyses were
performed to examine the strength of interrelationships between the pain-related variables
and post-intervention treatment adherence. These correlational analyses addressed
Hypotheses 1 and 2. Second, a series of paired sample t-tests were conducted to evaluate
extent of change in the proposed predictor variables (depression, anxiety, pain self-efficacy,
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and fear avoidance), as several subsequent analyses included change in these variables as
predictors of patient adherence to their post-intervention treatment plans.
For main analyses, a hierarchical regression analysis was conducted to test the
combined and relative contributions of pre- (Step II) and post-intervention (Step III)
measurements of depression, anxiety, pain self-efficacy, and fear-avoidance in predicting
post-intervention treatment adherence, as per Hypothesis 3. Covariates of age, gender, and
perceived disability were entered into the model in Step I, given potential for these
demographic factors and perceived disability level to influence adherence. Finally,
moderation analyses using the PROCESS plugin (Hayes, 2013) were undertaken to test
Hypothesis 4; namely, the possibility that change in symptoms from pre- to post-intervention
may moderate the predictive value of pre-intervention values of pain-related variables on
post-intervention treatment adherence. Eight moderation analyses were conducted; one for
each of the pain-related variables (depression, anxiety, pain self-efficacy, and fear avoidance)
modelling pre-intervention or post-intervention versions of these variables separately as IVs.
Covariates of age, gender, and perceived disability were included for each of these
moderation models.
Statistical significance testing for these models was augmented with estimates of
effect size. Applying Ferguson’s (2009) guidelines, Cohen’s d values from t-tests were
interpreted as follows: Cohen’s d < .41 = trivial effect, d = .41 – 1.14 = a small, practically
significant effect, d = 1.15 – 2.69 = a moderate effect, and d > 2.69 = a strong effect. For
correlational analyses, r values < .2 = trivial effect, r = .2 - .49 = a small, practically
significant effect, r = .5 - .79 = moderate effect, and r > .79 = large effect. These r value
guidelines were applied for semi-partial correlations as well.
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5.3 Results
There was less than 2% missing data overall. Missing values were imputed using
expectation maximization (Field, 2013). No further data transformations were necessary as
data conformed to key assumptions of the general linear model (outliers, normality, absence
of multicollinearity, etc.).
As shown in Table 5 pain self-efficacy was the only significant correlate of post-
intervention treatment adherence at both pre- and post-intervention; however, these
correlation effects were relatively small. Overall, pain self-efficacy at post-intervention was
the only variable shown to correlate with all other variables, ranging from small to large
effects (r = -.62 to .25).
Table 5. Means, standard deviations and inter-correlations among pain-related factors and
treatment adherence
1 2 3 4 5 6 7 8 9 10
1. DIS 1 1
2. SE 1 -.62** 1
3. SE 2 -.06 .25* 1
4. FA 1 -.10 .14 -.37** 1
5. FA 2 .40** -.25* -.34** .38** 1
6. Dep 1 .06 .31** -.62** .44** .51** 1
7. Dep 2 .03 -.21 -.62** .50** .57** .75** 1
8. Anx 1 .17 -.49** -.34** .13 .41** .73** .47** 1
9. Anx 2 -.02 -.18 -.53** .53** .54** .74** .87** .67** 1
10. TA .01 .23* .25* .12 .14 -.16 -.17 -.20 -.07 1
M 12.17 20.79 28.95 45.84 40.51 16.66 13.74 11.74 12.00 42.93
SD 3.84 11.96 13.17 9.87 8.44 10.76 9.98 10.63 8.19 10.14
** Correlation is significant at the .01 level, * Correlation is significant at the .05 level.
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DIS 1 = Perceived disability pre-intervention; SE 1 = Self-efficacy pre-intervention; SE 2 = Self-efficacy post-
intervention; FA 1 = Fear avoidance pre-intervention; FA 2 = Fear avoidance post-intervention; Dep 1 =
Depression pre-intervention; Dep 2 = Depression post-intervention; Anx 1 =Anxiety pre-intervention; Anx 2
=Anxiety post-intervention; TA = 3-6 months post-intervention follow up of treatment adherence
Means and standard deviations for the depression and anxiety scales both represent
moderately severe levels (see Table 5). At pre-intervention, 55.7% (n=34) of participants
presented with scores above the cut-off for at least moderate depression and 54% (n=33)
participants with scores above the cut-off for moderate anxiety. At post-intervention, 54.1%
(n=33) of participants presented with scores above the cut-off for depression and 62.2%
(n=38) participants with scores above the cut-off for anxiety. Moderate to severe interference
in participants’ self-efficacy for managing their pain was also observed for the sample overall
at both pre- and post-intervention time-points.
5.3.1 Adherence to treatment plan for post-intervention
Various modalities of treatment were provided to participants during pain
management, depending on individual needs; 97.4% of patients received physiotherapy,
84.6% psychology, 62.2% occupational therapy, and 43% hydrotherapy. These modalities
provided various treatment recommendations for patients to adhere to post-intervention. Of
the recommendations provided, exercise was adhered to some of the time for 30% of patients
and most or all of the time by 74% of participants; biomechanics was adhered to some of the
time by 17% of patients and 83% reported adhering most or all of the time; 10% did not use
their recommended relaxation tasks, while 18% reported using them some of the time, and
the remaining 72% reported use most or all of the time; activity pacing was adhered to some
of the time by 26% of patients and most or all of the time by 74% of the sample; 2% of
patients who were recommended stress and mood management did not use the activities,
while 28% adhered some of the time, and 70% adhered most or all of the time.
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5.3.2 Paired-samples t-tests
Paired-samples t-tests showed significant improvement from pre- to post-intervention
for depression, t(60) = -3.10, p = .003, Cohen’s d = .41; fear-avoidance, t(60) = -4.06, p <
.001, Cohen’s d = .52; and pain self-efficacy, t(60) = 4.12, p < .001, Cohen’s d = .53. No
significant difference was found for anxiety from pre- to post-intervention, t(60) = -.26, p =
.799, Cohen’s d = .04.
5.3.3 Hierarchical regression
As shown in Table 6, the hierarchical regression showed that the covariates (age,
gender, and perceived disability at baseline) accounted for approximately 1% of the variance
in adherence; R2 = .01, F(3,57) = 0.11, p = .95. At Step I, none of the predictors were
significant. Inclusion of the variables measured pre-intervention to the model at Step II
accounted for an additional 11% variance; ΔR2 = .11, F(4, 53) = 1.66, p = .173. None of the
predictors were significant at Step II. Inclusion of the post-intervention predictors at Step III
accounted for a further 16% of variance; ΔR2 = .16, F(4, 49) = 2.73, p = .040. Collectively,
the predictors accounted for 28% of the variance in adherence; R2 = .28, F(11,49) = 1.71, p =
.099. Depression and fear avoidance (both at post-intervention) were the only significant
unique predictors (β = -.84, p = .024, sr = -.28 and β = .37, p = .048, sr = .25, respectively).
Table 6. Summary of pain-related variables predicting 3-6 month post-intervention treatment
non-adherence
B t sr p
Step I
Age .00 -0.50 -.07 .619
Gender -.03 -0.27 -.04 .787
Disability pre-intervention .00 0.03 .00 .975
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*p<.05 (two-tailed)
5.3.4 Moderation
Moderation analyses were conducted to evaluate the possibility that the effects of the
risk factors (depression, anxiety, pain self-efficacy, and fear avoidance) on post-intervention
treatment adherence may depend on level of improvement in these symptoms. The interaction
between pre-intervention anxiety and change in anxiety from pre- to post-intervention was
significant (b =.002, p = .04, R2 = .09). As shown in Figure 7, the effect of pre-intervention
anxiety on post-intervention treatment adherence depended on level of change in anxiety
from pre- to post-intervention. Individuals who initially had lower levels of anxiety (i.e., pre-
intervention) were more likely to adhere to post-intervention treatment if their anxiety
Step II
Age .00 -0.22 -.03 .824
Gender -.03 -0.28 -.04 .782
Disability pre-intervention .02 1.21 .16 .230
Fear-avoidance pre-intervention .01 1.16 .15 .251
Pain self-efficacy pre-intervention .01 1.45 .19 .153
Depression pre-intervention -.01 -0.80 -.10 .428
Anxiety pre-intervention .00 0.08 .01 .938
Step III
Age .00 -0.49 -.06 .626
Gender .01 0.08 .01 .937
Disability pre-intervention .00 0.07 .01 .942
Fear-avoidance pre-intervention .00 0.26 .03 .794
Fear-avoidance post-intervention .02* 2.03 .25 .048
Pain self-efficacy pre-intervention .00 0.12 .02 .332
Pain self-efficacy post-intervention .01 1.41 .17 .165
Depression pre-intervention .01 0.98 .12 .332
Depression post-intervention -.04* -2.33 -.28 .024
Anxiety pre-intervention -.02 -1.87 -.23 .068
Anxiety post-intervention .04 1.93 .23 .060
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worsened by post-intervention. In contrast, individuals with low levels of anxiety who
experienced improvements in anxiety during the intervention phase were slightly less likely
to adhere to their post-intervention treatment plan.
The interaction between pre-intervention depression and change in depressive
symptoms from pre- to post-intervention (b = .00, p = .47, R2 = .02), pre-intervention self-
efficacy and change in self-efficacy (b = .00, p = .70, R2 = .00), and pre-intervention fear-
avoidance and change in fear avoidance (b = .00, p = .18, R2 = .03) were all non-significant
predictors of adherence.
A similar pattern was found when post-intervention variables were used. That is, the
interaction between post-intervention depression and change in depressive symptoms from
pre- to post-intervention (b = .00, p = .53, R2 = .00), post-intervention anxiety and change in
anxiety (b = .00, p = .29, R2 = .02), post-intervention pain self-efficacy and change in pain
self-efficacy (b = .00, p = .16, R2 = .03), and post-intervention fear avoidance and change in
fear avoidance (b = .00, p = .81, R2 = .00) were all non-significant predictors of post-
intervention treatment adherence.
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Figure 7. Graph of the moderating effect of anxiety improvement during treatment for the
relationship between pre-treatment anxiety (AnxietyT1) and level of treatment adherence.
Scores on anxiety at pre-treatment are centered at the mean
5.4 Discussion
Despite considerable exploration of the influence of psychological factors on
prognosis in chronic pain contexts, few studies have explored the impact of these factors on
treatment adherence, particularly in the post-treatment maintenance phase (Thompson et al.,
2016). The present longitudinal study sought to remedy this by testing the predictive value of
four previously identified psychological risk factors (fear-avoidance, pain self-efficacy,
depression, and anxiety) for post-intervention treatment adherence following a pain
management intervention. These risk factors were measured pre- and post-intervention to
evaluate how timing of measurement and potential change in these risk factors may predict
post-intervention treatment adherence. Overall, findings provided mixed support for
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hypotheses about the role of these predictors, as measured at these time-points, in treatment
adherence.
When viewed at the bivariate level, pain self-efficacy (at pre- and post-intervention)
was the only significant correlate of post-intervention treatment adherence. This finding is
consistent with other research (Brus van de Laar, Taal, Rasker & Wiegman, 1999; Medina-
Mirapeix et al., 2009; Thompson et al., 2016), which has also found a link between pain self-
efficacy and post-intervention treatment adherence. Notably, the adherence and pain self-
efficacy correlation was only marginally larger for post-treatment than pre-treatment self-
efficacy despite observed improvements in pain self-efficacy by post-intervention. Given the
low correspondence between self-efficacy scores at these two time-points, it is possible that
these different measurements of self-efficacy may be associated with treatment adherence in
different ways. For instance, whereas some individuals may be motivated to adhere post-
intervention due to noticeable gains in self-efficacy during treatment, others may persist in
spite of lack of gains (or even deterioration in pain self-efficacy). Further research that
incorporates patient motivation may allow for direct testing of this proposition.
Non-significant associations between treatment adherence and depression, anxiety,
and fear-avoidance may be explained in several ways. Firstly, the pattern of findings may
reflect the impact of time of assessment. That is, some variables such as fear avoidance may
be important earlier in a chronic pain episode, while confidence in one’s ability to manage
despite the pain may be important overall (Denison, Asenlof, & Lindberg, 2004). As such,
the small correlations obtained for these variables may be an accurate reflection of their
impact at the time-points they were measured, but miss their larger, true effect that perhaps
occurs earlier in the treatment cycle. Alternatively, the true effects of these variables on
adherence may be masked by confounds, such as individual differences in self-efficacy that
were not controlled for in these bivariate analyses. For example, depression could be
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moderated by pain self-efficacy rather than being a strong primary predictor of post-
intervention treatment adherence (Jerant Kravitz, Moore-Hill, & Franks, 2008). Or there
could simply be no relationship; the intervention does not affect these variables.
Testing combinations of these proposed predictors provided several additional
insights. First, in combination, the proposed risk factors predicted over one-quarter of the
variance in treatment adherence, with more of this explained variance attributable to the post-
intervention grouping of predictors. The amount of unexplained variance in this model
suggests that psychological factors alone may be insufficient to explain individual differences
in post-treatment adherence. Thus, although the intention in the present study was to test a
plausible and parsimonious model of predictors, a more complex model may be needed to
more fully understand the factors that drive treatment adherence. Second, within this
multivariable context, only post-treatment fear avoidance and depression were uniquely
predictive of adherence, which is counter to the pattern of bivariate correlations. The non-
significance of self-efficacy in this model despite it having the strongest bivariate
associations with adherence may be attributable to self-efficacy being broadly related to the
other psychological constructs in the model. As such, the variance it has to contribute to
adherence overlaps with these other predictors.
Finally, moderation analyses revealed that change in anxiety was the only variable to
moderate the main effects of a proposed risk factor on treatment adherence. Individuals who
had low levels of anxiety at pre-intervention exhibited greatest adherence to post-discharge
treatment plans if they experienced a substantial increase in anxiety during the treatment
phase. In contrast, those with low level symptoms at pre-intervention who experienced
reductions in their symptoms tended to have lower adherence to the post-discharge treatment
plan. As the present study explored anxiety specifically in relation to pain symptoms, it is
possible that these findings indicate that the change in anxiety that the patient felt about their
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symptoms may have motivated stronger adherence for patients whose anxiety worsened, but
led to a more relaxed attitude to their treatment plan for those who experienced reduced
anxiety over their symptoms.
For the psychological variables, the lack of moderation effects may be due to the fact
that more than half of the participants in the present study remained clinically depressed (i.e.,
moderate to extremely severe symptoms) post-intervention. Similarly, the majority of
participants in the present study maintained moderate levels of fear-avoidance post-
intervention.
5.4.1 Limitations
Despite the use of a clinical sample and longitudinal design, present findings should
be viewed within the context of study limitations. Although proposed predictors were
measured at traditional time-points (pre-intervention and post-intervention), it is possible that
the true effects of these variables were missed due to failing to measure at their appropriate
time of impact (Timmons & Preacher, 2015). More detailed measurement within and beyond
the treatment phase may help to clarify whether null findings are attributable to issues of
measurement timing or rather reflect the true nature of their influence on adherence. Related
to this, some imprecision in estimation of the effects of these predictors on post-treatment
adherence may have arisen due to individual differences in when they filled out the adherence
measure. If adherence systematically reduces over time, then adherence levels may be
expected to be lower for individuals who returned their adherence survey at 6 months than for
those who completed it at the time they received it (i.e., 3-months post-discharge).
Further, it is possible that the relationships between post-intervention treatment
adherence and the investigated predictors may have been diminished due to self-report biases.
That is, the subjective recall of adherence and the potential desire of patients to pose in a
positive light may have led many participants to report high levels of adherence regardless of
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actual behaviour, thus, reducing variance among predictors. Finally, it is worth considering
the impact of the adherence measure on present findings. The present study instead utilised a
tailor-made measure to assess adherence to various activities that are recommended at the
clinic these patients were recruited from. This approach has face validity (as it was created in
consultation with employees at this pain clinic, and the measure covers activities that the
patients are likely to be recommended), and the items were shown to be internally consistent.
Nevertheless, it is possible that the low correlations between psychological factors and
adherence in the present study may be attributable to the way adherence was measured.
5.4.2 Implications and future directions
Despite design limitations, present findings offer re-affirmation for the notion that
psychological factors may be markers for likely adherence to post-treatment instructions for
chronic pain sufferers. This recommendation of monitoring of known correlates of treatment
success is in line with best practice procedures carried out among pain management program
providers; that is, to measure change in pain-related variables pre- and post-intervention (Hill
et al., 2011). However, as highlighted in the literature, often measures administered post-
program are aimed at identifying treatment efficacy as opposed to highlighting predictors of
future adherence levels (McCracken, MacKichan & Eccleston, 2007). By utilising current
research to promote a greater focus on post-intervention predictors of poor post-discharge
adherence to treatment maintenance plans, patients at greater risk can be appropriately
flagged and finite resources may be prioritised to these individuals, thereby enabling for
increased post-program support and reduced re-admission rates.
Even so, conclusions based on present findings should be tempered by the size of
obtained effects, and remaining uncertainty about the most appropriate time to measure these
constructs. While null findings from the present study may indicate that the chosen predictors
are weakly or not related to treatment adherence post-intervention, it is also possible that
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failure to model these associations at the appropriate time-points in the treatment cycle may
have led to under-estimated effects. Moreover, the finding that change in anxiety moderated
effects of this variable on treatment adherence provides some evidence to suggest that static
assessments of psychological functioning may be an insufficient basis for determining level
of adherence to a patient’s given treatment plan. Further evaluation with an increased number
of assessments during and beyond the intervention, as well as consideration of how best to
model these predictor-outcome associations is necessary.
In summary, present findings offer some support for the notion that psychological
constructs may be relevant to prediction of treatment adherence post-intervention for chronic
pain patients. However, these effects tended to be small. Given the considerable variability in
treatment adherence levels identified in the present study, further investigation into the
factors that might identify treatment adherence vs non-adherence is clearly warranted.
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References
Ajzen, I. (1991). The theory of planned behaviour. Organizational Behavior and Human
Decision Processes, 50(2), 179-211. http://doi.org/10.1016/0749-5978(91)90020-T
Asghari, A. & Nicholas, M.K. (2001). Pain self-efficacy beliefs and pain behaviour. A
prospective study. Pain 94: 85–100. http://doi.org/10.1016/S0304-3959(01)00344-X
Australian Health Services Institute. (2017). Adult clinical change calculator. Retrieved from
http://ahsri.uow.edu.au/eppoc/resources/index.html
Broekmans, S., Dobbels, F., Milisen, K., Morlion, B., & Vanderschueren, S. (2009).
Medication adherence in patients with chronic non-malignant pain: Is there a problem?
European Journal of Pain, 13, 115-123. 10.1016/j.ejpain.2008.02.010
Brus, H., van de Laar, M., Taal, E., Rasker, J., & Wiegman, O. (1999). Determinants of
compliance with medication in patients with rheumatoid arthritis: the importance of
self-efficacy expectations. Patient Education and Counseling, 36, 57-64.
http://doi.org/10.1016/S0738-3991(98)00087-1
Cipher, D.J., Fernandez, E., & Clifford, P.A. (2002). Coping style influences compliance
with multidisciplinary pain management. Journal of Health Psychology, 7, 665-673.
https://doi.org/10.1177/1359105302007006870
Demyttenaere, K., Bruffaerts, R., Lee, S., Posada-Villa, J., Kovess, V., Angermeyer, M.C., …
Von Korff, M. (2007). Mental disorders among persons with chronic back or neck pain:
Results from the world mental health surveys. Pain, 129, 332-342.
https://doi.org/10.1016/j.pain/2007.01.022
Denison, E., Asenlof, P., & Lindberg, P. (2004). Self-efficacy, fear-avoidance, and pain
intensity as predictors of disability in subacute and chronic musculoskeletal pain
patients in primary health care. Pain, 111, 245-252.
http://doi.org/10.1016/j.pain.2004.07.001
![Page 186: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/186.jpg)
172
Dworkin, R.H., Turk, D.C., McDermott, M.P., Peirce-Sandner, S., Burke, L.B., Cowan, P., et
al. (2009). Interpreting the clinical importance of group differences in chronic pain
clinical trials: IMMPACT recommendations. Pain,146, 238-244.
http://doi.org/10.1016/j.pain.2009.08.019
Faul, F., Erdfelder, E., Buchner, A., & Lang, A-G. (2009). Statistical power analyses using
G*Power 3.1: Tests for correlation and regression analyses. Behavior Research
Methods, 41, 1149-1160. https://doi.org/10.3758/BRM.41.4.1149
Field, A. (2013). Discovering statistics using IBM SPSS statistics. Sage.
Ferguson, C.J. (2009). An effect size primer: A guide for clinicians and researchers.
Professional Psychology: Research and Practice, 40, 532-538.
https://doi.org/10.1037/a0015808
Ferreira, M.S., & Pereira, M.G. (2014). The mediator role of psychological morbidity in
patients with chronic low back pain in differentiated treatments. Journal of Health
Psychology, 19, 1197-1207. https://doi.org/10.1177/1359105313488970
Gormsen, L., Rosenberg, R., Bach, F.W., & Jensen, T.S. (2010). Depression, anxiety, health-
related quality of life and pain in patients with chronic fibromyalgia and neuropathic
pain. European Journal of Pain, 14, 127.e1-e8. 10.1016/j.ejpain.2009.03.010
Hayes, A.F. (2013). Introduction to mediation, moderation, and conditional process analysis:
A regression-based approach. New York, NY: Guilford Press.
Hill, J.C., Whitehurst, D.G.T., Lewis, M., Bryan, S., Dunn, K.M., Foster, N.E., et al. (2011).
Comparison of stratified primary care management for low back pain with current best
practice (STarT Back): A randomised controlled trial. Lancet, 378, 1560-1571.
http://doi.org/10.1016/S0140-6736(11)60937-9
Holmes, E.A.F., Hughes, D.A., & Morrison, V.L. (2014). Predicting adherence to
medications using health psychology theories: A systematic review of 20 years of
![Page 187: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/187.jpg)
173
empirical research. Value in Health, 17(8), 863-76.
http://doi.org/10.1016/j.val.2014.08.2671
Imani, F. & Safari, S. (2011). “Pain relief is an essential human right”, we should be
concerned about it. Anesthesiology and Pain Medicine, 1, 55-57.
10.5812/kowsar.22287523.2306
Jensen, M.P., Karoly, P., & Huger, R. (1987). The development and preliminary validation of
an instrument to assess patients’ attitudes toward pain. Journal of Psychosomatic
Research, 31, 393-400.
Jerant, A., Kravitz, R., Moore-Hill, M., & Franks, P. (2008). Depressive symptoms
moderated the effect of chronic illness self-management training on self-efficacy.
Medical Care, 46, 523-531. 10.1097/MLR.0b013e31815f53a4
Kaivanto, K. K., Estlander, A.-M., Moneta, G. B., & Vanharanta, H. (1995). Isokinetic
performance in low back pain patients: The predictive power of the self-efficacy scale.
Journal of Occupational Rehabilitation, 5, 87-99. 10.1007/BF02109912
Kori, S.H., Miller, R.P., & Todd, D.D. (1990). Kinisiophobia: a new view of chronic pain
behaviour. Pain Management, 35-43.
Leventhal, H., Phillips, L.A., & Burns, E. (2016). The Common-Sense Model of Self-
Regulation (CSM): A dynamic framework for understanding illness self-management.
Journal of Behavioral Medicine, 39, 935-46. http://doi.org/10.1007/s10865-016-9782-2
Lovibond, P.F. & Lovibond, S.H. (1995). The structure of negative emotional states:
Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression
and Anxiety Inventories. Behavior Research and Therapy, 33, 335-343.
http://doi.org/10.1016/0005-7967(94)00075-U
McCracken, L.M., MacKichan, F., & Eccleston, C. (2007). Contextual cognitive behavioral
therapy for severely disabled chronic pain sufferers: Effectiveness and clinically
![Page 188: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/188.jpg)
174
significant change. European Journal of Pain, 11, 314-322.
http://doi.org/10.1016/j.ejpain.2006.05.004
Maddux, J.E., & Rogers, R.W. (1983). Protection motivation theory and self-efficacy: A
revised theory of fear appeals and attitude change. Journal of Experimental Social
Psychology, 19, 469-479. http://doi.org/10.1016/0022-1031(83)90023-9
Medina-Mirapeix, F., Escolar-Reina, P., Gascón-Cánovas, J.J., Montilla-Herrador, J.,
Jimeno-Serrano, F.J., & Collins, S.M. (2009). Predictive factors of adherence to
frequency and duration components in home exercise programs for neck and low back
pain: an observational study. BMC Musculoskeletal Disorders, 10, 1-9. 10.1186/1471-
2474-10-155
Milne, S., Sheeran, P., & Orbell, S. (2000). Prediction and intervention in health-related
behaviour: A meta-analytic review of Protection Motivation Theory. Journal of Applied
Social Psychology, 30, 106-143. DOI: 10.1111/j.1559-1816.2000.tb02308.x
Nicholas, M. (1989). Self-efficacy and chronic pain. Paper presented at the Annual
Conference of the British Psychological Society, St. Andrews, UK.
Orenius, T., Koskela, T., Koho, P., Pohjolainen, T., Kautiainen, H., Haanpää, M., & Hurri, H.
(2012). Anxiety and depression are independent predictors of quality of life of patients
with chronic musculoskeletal pain. Journal of Health Psychology, 18, 167-175.
https://doi.org/10.1177/1359105311434605
Roebuck, C.M., Liberman, J.N., Gemmill-Toyama, M., & Brennan, T.A. (2011). Medication
adherence leads to lower health care use and costs despite increased drug spending.
Health Affairs, 30, 91-99. 10.1377/hlthaff.2009.1087
Rosenstock, I., Strecher, V., & Becker, M. (1988). Social learning theory and the health
belief model. Health Education Quarterly, 15, 175-83.
![Page 189: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/189.jpg)
175
Thompson, E., Broadbent, J., Bertino, M., & Staiger, P.K. (2016). Do pain-related beliefs
influence treatment adherence? A systematic review. Clinical Journal of Pain, 32, 164-
178. 10.1097/AJP.0000000000000235
Timmons, A.C., & Preacher, K.J. (2015). The importance of temporal design: How do
measurement intervals affect the accuracy and efficiency of parameter estimates in
longitudinal research? Multivariate behavioral research, 50(1), 41-55.
doi.org/10.1080/00273171.2014.961056
Wertli, M.M., Rasmussen-Barr, E., Weiser, S., Bachmann, L.M., & Brunner, F. (2014). The
role of fear-avoidance beliefs as a prognostic factor for outcome in patients with
nonspecific low back pain: a systematic review. Spine Journal, 14, 816-836.
http://doi.org/10.1016/j.spinee.2013.09.036
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Chapter 6
General Discussion
6.1 Overview of studies conducted
The aim of this thesis was three-fold: the first aim was to review the current literature
in order to gain a greater understanding of the associations between cognitions and treatment
adherence among chronic pain patients attending multidisciplinary treatment programs. The
second aim was to examine the interrelationships among specific psychological variables and
pain symptoms in individuals presenting for chronic pain management. Finally, the third aim
was to explore the combined and relative predictive value of previously identified cognitive
(pain self-efficacy and fear-avoidance) and psychological (depression and anxiety) predictors
of post-treatment adherence as well as the most appropriate time to measure their predictive
value. To address these three specific aims, three studies were conducted. Study one was a
review of the literature examining pain-related beliefs in relation to treatment adherence
(Thompson, Broadbent, Bertino & Staiger, 2016). Study Two was a cross-sectional study
testing the interrelationships between various cognitive and psychological factors known to
impact pain symptoms (Thompson, Broadbent, Fuller-Tyszkiewicz, Bertino & Staiger, under
review). Finally, Study Three was a longitudinal study investigating the predictive value of
various psychological factors and their measurement timing on post-treatment adherence
(Thompson, Broadbent, Fuller-Tyszkiewicz, Bertino & Staiger, under review).
6.1.1 Study One
Study One was a systematic review of the literature examining psychological
correlates of multidisciplinary treatment adherence (Thompson et al., 2016). The review
found that from the years 2000 to 2014, there were 10 published articles which specifically
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examined pain-related beliefs and multidisciplinary treatment adherence among the chronic
pain population (Coppack, Kristensen & Karaheorghis, 2012; Robinson et al., 2004; Mannion
et al., 2009; Nicholas et al., 2012; Dobkin et al., 2005; Dobkin et al., 2010; Glombiewski et
al., 2010; Heapy et al., 2005; Curran et al., 2009; Engstrӧm & Ӧberg, 2005). These studies
highlighted that pain-related beliefs such as pain self-efficacy (Coppack, Kristensen &
Karaheorghis, 2012; Mannion et al., 2009; Nicholas et al., 2012., Dobkin et al., 2005; Dobkin
et al., 2010; Heapy et al., 2005; Curran et al., 2009), perceived disability (Dobkin et al., 2005;
Dobkin et al., 2010; Glombiewski et al., 2010), catastrophizing (Mannion et al., 2009;
Nicholas et al., 2012; Curran et al., 2009), control beliefs (Robinson et al., 2004; Mannion et
al., 2009; Engstrӧm & Ӧberg, 2005), fear-avoidance beliefs (Mannion et al., 2009; Nicholas
et al., 2012), perceived benefits of treatment recommendations (Robinson et al., 2004;
Dobkin et al., 2005; Engstrӧm & Ӧberg, 2005) and perceived barriers of treatment
recommendations (Dobkin et al., 2005; Engstrӧm & Ӧberg, 2005) contribute to chronic pain
patient’s ability to adhere to prescribed treatment regimens and post-treatment self-
management.
The findings of the systematic review revealed that pain self-efficacy is the most
commonly researched pain-related belief in relation to treatment adherence. Whereas, general
self-efficacy refers to one’s belief in their ability to perform certain tasks (Bandura, 1977),
pain self-efficacy specifically refers to one’s belief in their ability to perform certain tasks,
despite the experience of pain (Nicholas, 1989). Seven of the ten studies examined the effect
of pain self-efficacy on treatment adherence (at pre-program, mid-program and/or post-
program), with five of those studies showing that low pain self-efficacy is predictive of
reduced treatment adherence (Coppack, Kristensen & Karaheorghis, 2012; Mannion et al.,
2009; Nicholas et al., 2012; Dobkin et al., 2010; Curran et al., 2009). Further, the results of
one study (Mannion et al., 2009) highlighted that increases in pain self-efficacy over the
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course of treatment predicted increased adherence. The findings also suggest that treatment
adherence is determined by a combination of other pain-related beliefs (perceived disability,
catastrophizing, fear-avoidance beliefs, and perceived benefits and barriers), either supporting
or inhibiting the ability of chronic pain patients to adhere to treatment recommendations over
time. That is, despite pain self-efficacy being the most commonly researched, various other
pain-related beliefs were found to be important factors in determining treatment adherence.
The implications and key findings of the review provided the impetus for the two main
studies of this thesis. For this reason, a key and unique question to be addressed in the present
research was based on clarifying the predictive nature of various known psychological factors
and their interrelationships on multidisciplinary post-treatment adherence.
6.1.2 Study Two
Study Two consisted of a cross-sectional investigation of the interrelationships
between key pain-related cognitions and psychological factors known to impact pain
symptoms. The variables examined were drawn from the systematic review and clinical
expertise. A secondary aim involved utilising an innovative analytic technique (network
analysis) to gain further insights into the interrelationships among psychological constructs
and pain symptoms. Network analysis examines the pattern of relationships between causal
factors and a focal event, providing a model of the perceived causal structure between
variables (Reser & Muncer, 2004). That is, the perceived causal structure for co-morbid
affective disorders and pain symptoms (focal event) were examined in relation to various
putative cognitive causes.
One hundred and sixty nine individuals attending a multidisciplinary chronic pain
program participated in the study. Variables were collected at intake to the program which
consisted of depression, anxiety, and pain-related cognitions such as pain self-efficacy, fear-
avoidance beliefs, perceived control and perceived disability. Findings from Study Two
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indicated some interrelations among all of the psychological factors investigated, albeit the
nature and magnitude of these associations differed. Some variables, such as pain self-
efficacy, tended to have direct associations with each variable (even after partialling out
variance of all remaining variables). Other variables, such as fear avoidance, perceived
control, and perceived disability, were shown to serve more as links between other variables,
especially for relationships involving the mental health variables (depression and anxiety).
For instance, depression and pain symptoms were linked indirectly via perceived control, and
avoidance connected disability with depression. Finally, although anxiety had a moderate
strength value in the model (suggesting reasonable magnitude relationships), this was driven
primarily by its link with depression as anxiety was unrelated to any other variables in the
model. Once anxiety was removed from the model, the centrality of self-efficacy in directly
linking to as well as bridging between other modelled variables was made clear. Perceived
disability was second strongest in this revised model. In summary then, this pattern of
findings is consistent with the notion that enhancing self-efficacy and reducing perceptions of
pain may enable change in both perceptions of disability and experiences of mental illness in
clinical pain populations.
6.1.3 Study Three
Study Three was a longitudinal cohort study which aimed to examine the predictive
psychological factors related to adherence to multidisciplinary recommendations post-
treatment (i.e., between discharge and a 3-6 month follow-up session). This study measured
pain self-efficacy, fear-avoidance beliefs and pre-intervention perceived disability (informed
by Study One and Two) as well as depression and anxiety (informed by Study Two) and their
importance to post-intervention adherence. As an extension of Study One and Two, Study
Three sought to evaluate how the measurement timing and change in these psychological risk
factors over time predict adherence post-treatment. Chronic pain patients attending a
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multidisciplinary clinic completed questionnaires at three time points: assessment, discharge
and three-to-six months post-program (based on their scheduled follow-up appointment).
In line with findings from the systematic review, Study Three found pain self-efficacy
to be a predictor variable shown to positively correlate with adherence post-treatment; in fact,
the results indicated pain self-efficacy to be the only significant correlate (albeit small) of
post-treatment adherence. Moderation analyses showed change in anxiety to be the only
variable to moderate the main effects of a proposed risk factor on treatment adherence. For
example, individuals with lower levels of anxiety at pre-intervention who then experienced a
worsening of anxiety symptoms were found to be more adherent to their post-discharge
treatment plan. Conversely, individuals with higher levels of anxiety at pre-intervention who
then experienced improvements of anxiety symptoms were found to be less adherent post-
program. The latter finding demonstrating the impact that awareness of rising anxiety levels
seen post-program, may have on patients’ motivation to maintain prescribed treatment.
6.2 Findings for the psychological factors examined
The following sections are an integrated discussion of the three present studies with
respect to the key psychological variables examined.
6.2.1 Pain self-efficacy
The findings from this thesis provide some support in line with previous literature
highlighting the importance of pain self-efficacy for treatment adherence (Nicholas et al.,
2012; Coppack, Kristensen & Karaheorghis, 2012; Dobkin et al., 2010). That is, Study One
found pain self-efficacy to be the most commonly researched pain-related belief in relation to
treatment adherence. In addition, Study Three found pain self-efficacy (at pre- and post-
intervention to be the only variable significantly correlated with post-treatment adherence.
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Despite its bivariate correlation with adherence, pain self-efficacy was not shown to be
uniquely predictive of treatment adherence within a multivariate context. This may be due to
pain self-efficacy being broadly related to the other psychological constructs in the model;
whereby, the variance it has to contribute to adherence overlaps with these other predictors.
Pain self-efficacy was also hypothesised to be an important risk factor for other pain
associated outcomes such as co-morbid mental health conditions. This is based on the
premise that factors that influence one’s ability to adhere to treatment may also impact on
mental health and vice versa. Numerous studies (Börsbo, Gerdle & Peolsson, 2010; Sardá Jr.,
Nicholas, Asghari & Pimenta, 2009; Asghari, Julaeiha & Godarsi, 2008) have found pain
self-efficacy to be significantly and negatively associated with depressive symptoms. The
lack of belief in one’s own ability to manage persistent pain has been shown to be a
significant predictor of the extent to which individuals with chronic pain become depressed
and/or anxious. Understandably, patients at pre-treatment who have not yet had an
opportunity to experience success in performing treatment techniques appear more likely to
display depressive symptoms such as low mood and hopelessness in response. In addition to
previous research examining this relationship (meta-analytic review; Jackson et al., 2014)
results from Study Two also show support for the relationships between pain self-efficacy
and co-morbid mental health problems with some sizable direct associations found between
these variables, even after controlling for other cognitive predictors. These findings support
the influence of pain self-efficacy on co-morbid mental health problems. Interestingly, in
contrast, results from Study Three showed pain self-efficacy to have no significant influence
on psychological coping. Study Three indirectly assessed the relationship between these
factors at pre- and post-treatment, however, no significant associations were found. Given the
conflicting findings of past and current research, further investigation clarifying the direct
and mediating effects of pain self-efficacy on mental health problems is warranted.
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6.2.2 Anxiety
Study Two identified a connection between depressive and anxiety symptoms in
relation to one’s pain experience. However, anxiety was not found to directly relate to any
other psychological constructs in the network model examined. This may be partially
explained by the strong correlation found between anxiety and depressive symptoms.
However, it should also be noted that the relationships with psychological factors and pain
experience were consistently weaker for anxiety than for depressive symptoms. One possible
explanation for this is the DASS-21 anxiety measure may be more heavily
influenced/confounded with co-morbid medical conditions and medication side effects than
the depression measure (i.e. 4 of the 7 items including dry mouth, breathing difficulty, racing
heart and trembling hands). The lack of direct connection between anxiety and other
cognitive constructs included in Study Two is surprising given the vast literature in support of
such connections. For example, significant interrelationships between anxiety and fear-
avoidance beliefs have been extensively documented (Lucchetti, Oliveira, Mercante & Peres,
2012; Bailey, Carleton, Vlaeyen, & Asmundson, 2010; McCracken & Keogh, 2009). As
such, replication of Study Two findings is important. Results from Study Three did not reveal
a bivariate association between anxiety and treatment adherence. This is likely attributed to
the real-world confounding effects between uncontrolled variables (e.g., the relationship
between pain self-efficacy and depression). However, moderation analyses revealed change
in anxiety to be the only variable to moderate the main effects of a proposed risk factor on
treatment adherence. That is, individuals who presented with low levels of anxiety at pre-
intervention exhibited greatest adherence to post-discharge treatment plans if they
experienced a substantial increase in anxiety during the treatment phase. In contrast, those
with low level symptoms at pre-intervention who experienced reductions in their symptoms
tended to have lower adherence to the post-discharge treatment plan. It is possible that these
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findings indicate that the change in anxiety that the patient felt about their symptoms may
have motivated stronger adherence for patients whose anxiety worsened, but led to a more
relaxed attitude to their treatment plan for those who experienced reduced anxiety over their
symptoms. Based on this finding, treatment aimed at improving anxiety may not be as
important or effective for chronic pain self-management as previously thought (Nicklas,
Dunbar & Wild, 2010; Jack, McLean, Moffett & Gardiner, 2010). Research further exploring
how change in anxiety symptoms impacts on treatment adherence specifically is warranted to
clarify the value of identifying anxious chronic pain patients during intervention.
6.2.3 Depression
Study Two found depression to present with the highest strength value in the network
model. Moreover, depression revealed relatively high levels of betweenness, serving as the
shortest (and only) path to anxiety compared to the other variables in the model. As
mentioned in the previous section (i.e., 6.2.2), this may be partly attributable to a strong
association with anxiety. Study Two findings also showed depressive symptoms to directly
link to various cognitive constructs included in the network model. That is, depression
presented with a moderate closeness value, reflecting close proximity to fear-avoidance,
perceived control, and pain self-efficacy. Thus, it appears that when assessing for and treating
depression among chronic pain patients, consideration and further exploration of potentially
underlying cognitive factors (particularly, fear-avoidance, perceived control, and pain self-
efficacy) and their impact on psychological coping is warranted. When viewed at the
bivariate level, depressive symptoms were not found to significantly correlate with post-
treatment adherence in Study Three. This is contrary to literature examining this relationship
(Nicholas et al., 2012; Blashill, Perry & Safren, 2011; Jack et al., 2010). An explanation for
this finding may be that depression is moderated by other variables such as pain self-efficacy
rather than being a strong primary predictor of post-intervention treatment adherence. There
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is considerable support for this mediational effect as seen throughout the broader literature.
For example, Maeda et al.’s (2013) study found self-efficacy to mediate the contribution of
depression to treatment adherence among a large sample (N=252) of heart failure outpatients.
Further research exploring this relationship, specifically among chronic pain patients, would
be beneficial. Despite the lack of a bivariate association, multivariate analyses identified post-
intervention depression to be a unique predictor of adherence to post-discharge treatment
plans. In this respect, identifying chronic pain patients who are struggling with symptoms of
depression after a pain management program may be a key factor for improving post-
program self-management. A better understanding of the pathways in question will prompt
more refined methodology for treating chronic pain and subsequently improve pain-related
outcomes such as comorbidity and treatment adherence.
6.2.4 Fear-avoidance beliefs
The findings of Study Two identified fear-avoidance beliefs as being significantly
implicated in pain and affective disorder symptoms. That is, chronic pain patients with higher
fear-avoidance beliefs are at greater risk of displaying elevated symptoms of pain intensity as
well as depression and anxiety. The importance of high fear-avoidance as a risk factor for
anxiety is well documented throughout the literature (Lucchetti et al., 2012; Bailey, Carleton,
Vlaeyen, & Asmundson, 2010; McCracken & Keogh, 2009). Longitudinally, no significant
bivariate relationship was found between fear-avoidance beliefs and depression or anxiety.
Nor was change in fear-avoidance beliefs shown to have any moderating effect. Interestingly,
fear-avoidance scores remained moderately high for most pain patients at program
completion which may have impacted on the lack of moderation effects. Similarly, Study
One found limited support for the relationship between fear-avoidance beliefs and treatment
adherence. That is, only two of the ten papers included in the study examined this
relationship. Of these two studies, only one indicated higher degrees of adherence to
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treatment recommendations to be predictive of greater pre-post treatment changes in fear-
avoidance beliefs. However, similar to the pattern of relationships identified for depression,
longitudinal multivariate analyses identified post-intervention depression to be a unique
predictor of adherence. Therefore, chronic pain patients presenting with heightened fear-
avoidance at the completion of pain management may also be an important target for
improved post-program adherence. Overall, these findings provide some evidence for the
importance of identifying chronic pain patients with high fear-avoidance beliefs for treatment
adherence, particularly in the post-intervention phase, however, the relevance of fear-
avoidance for depression and anxiety remains somewhat unclear. Again, further research
aimed at replicating these findings is needed in order to enhance understanding of the
predictive value of fear-avoidance beliefs for pain and affective symptomatology.
6.2.5 Perceived disability and control
In Study One, three of the ten studies included examined the effect of perceived
disability on treatment adherence. Perceived control was also examined by three studies in
the systematic review. Whereas, two studies found moderate to strong negative associations
between perceived disability and treatment adherence, all three studies found no relationship
between perceived control and treatment adherence. Study Two findings also revealed limited
support for perceived control. Despite perceived control displaying direct links (to fear-
avoidance beliefs and depressive symptoms) within the examined network, its bridging
effects to other variables appeared weaker than those identified for other linked variables.
That is, results from Study Two showed perceived disability to also have direct effects on
other variables (pain self-efficacy and pain intensity), however, these effects appeared much
stronger than those identified for perceived control. In light of these findings, both perceived
disability and perceived control appear to have an influence (direct or as a mediator) on other
modelled constructs, albeit, perceived disability may serve as a more important mediator and
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risk factor for the development and maintenance of chronic pain outcomes. For this reason,
perceived disability was given preference for inclusion as a baseline measure in Study Three.
Results showed perceived disability at pre-intervention to not indicate a significant predictor
of treatment adherence. Future research would benefit from including discharge levels of
perceived disability to examine its effect in relation to post-treatment adherence from a
longitudinal perspective.
6.3 Novel investigations and findings
Study One is the only review that provides a systematic review of the research to-date
examining pain-related beliefs and treatment adherence. This review highlighted the
importance of pain self-efficacy in predicting chronic pain treatment adherence. It also
revealed several other pain-related beliefs to be important for self-management during and
after pain management intervention.
Study Two utilised an innovative analytic technique (network analysis) to gain further
insights into the interrelationships among psychological variables and pain symptoms in a
group of individuals seeking treatment for chronic pain. In addition, to the authors
knowledge, no prior studies have examined the specific combination of cognitive factors as
predictors of affective disorder symptoms or the pain experience within the same conceptual
model.
Despite considerable exploration of the influence of psychological risk factors
(anxiety, depression, fear avoidance, and self-efficacy) on prognosis in chronic pain contexts,
fewer studies have explored the impact of these factors concurrently on treatment adherence,
particularly in the post-treatment maintenance phase. This reflects the novel contribution of
Study Three. Considerable research is focused on examining program effectiveness at
discharge and the relative improvement of symptoms pre- and post-program. However, few
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studies have identified or explored the most appropriate time to measure the predictive value
of various specific psychological factors on post-treatment adherence. The present
longitudinal study sought to remedy this by testing the predictive value of four previously
identified psychological risk factors (pain self-efficacy, fear-avoidance beliefs, depression,
and anxiety) for post-intervention treatment adherence following a pain management
program. These risk factors were measured pre- and post-intervention to evaluate how timing
of measurement and potential change in these risk factors may predict post-intervention
treatment adherence.
Examination of the importance of measurement timing (pre- and post-intervention)
for these risk factors and treatment adherence is a methodology that had not been explored
previously. By testing these variables together and at different stages of intervention, Study
Three pinpointed depression and fear-avoidance (both at post-intervention) as the strongest
unique predictors of treatment adherence following a pain management program. These
findings confirm that post-intervention levels of specific psychological constructs are better
predictors (than pre-intervention levels) of post-discharge treatment adherence. This research
also provided a better understanding of how change in anxiety predicts post-intervention
adherence; with improvement of anxiety symptoms shown to conversely impact pain
patients’ ability to maintain self-management behaviours.
6.4 Treatment implications
The findings of this thesis have highlighted the importance of psychological factors
for effective post-treatment adherence and self-management behaviour. Treating clinicians of
chronic pain patients need to be aware of the impact that factors such as depression, fear-
avoidance beliefs and anxiety have on post-treatment adherence outcomes. The findings of
this thesis support previous research, which suggest that depression and fear-avoidance are
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important to identify prior to discharge from pain management programs to intervene and
improve adherence behaviour. The findings here extended on the knowledge of this
relationship by highlighting the need to prioritise post-intervention predictors of adherence to
self-management plans post-discharge. This is important as measures administered post-
program are often aimed at identifying treatment effectiveness as opposed to highlighting
predictors of poor adherence. With a refined focus, patients at greater risk can be
appropriately flagged and scheduled for follow-up, thus enabling for increased post-program
support and reduced likelihood of re-admission.
Depression and fear-avoidance have both previously been identified as modifiable
psychological factors (George, Valencia & Beneciuk, 2010; Smeeding, Bradshaw, Kumpfer,
Trevithick & Stoddard, 2010), which can be reduced with appropriate intervention to improve
treatment adherence outcomes. However, as pain management programmes generally run for
a finite period of time (i.e., weeks to months), severe psychological presentations can be
difficult to overcome completely. As such, pain management clinicians should be encouraged
to dedicate ample time to the re-assessment of client’s level of depression and fear-avoidance
post-program (i.e., discharge and follow-up), regardless of assessment results at intake.
Integrative re-assessment aimed at identifying at-risk individuals by highlighting predictors
of poor treatment adherence would help to target those in need of ongoing support and
community referral. By improving continuity of care, at-risk individuals can receive
intervention and monitoring beyond their involvement in pain management. Subsequently,
enabling better implementation and maintenance of learned self-management strategies,
therefore, reducing the likelihood of relapse into passive coping mechanisms.
It is important that clinicians working with chronic pain patients, understand the
relationship between fear-avoidance beliefs and mental health issues. Based on the current
findings, it is recommended that clinicians focus on identifying pain patients with high fear-
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avoidance beliefs and behaviours as this may indicate a risk factor for co-morbid mental
health problems and heightened pain intensity. There are many practical ways to reduce fear-
avoidance beliefs. For example, providing clinicians with adequate resources to expand on
patients’ understanding of the inherent cognitive, emotional and behavioural components
involved in the pain experience. This may help to alleviate common misconceptions; for
example, that fear-avoidance beliefs occur as a reaction to the physical sensation of pain
rather than it being a contributing factor to prolonged pain. Knowledge such as this may also
help to educate patients about the importance of physical movement in pain rehabilitation and
the disabling consequences of activity avoidance. A greater understanding and exploration
into the mechanisms of individual fear-avoidance will better enable patients to take proactive
steps against such unhelpful beliefs.
The present research provided an interesting insight into the relationship between
anxiety and treatment adherence. Although, change in anxiety symptoms over the course of
pain management is important to monitor, it appears that relying on self-report measures of
anxiety symptoms alone may not be sufficient to identify at-risk individuals. This was evident
in the present research which revealed heightened anxiety to improve self-management
behaviour, contrary to previous findings examining this relationship (Nicklas et al., 2010;
Jack et al., 2010). As such, clinicians are encouraged to dedicate time to conducting more in-
depth assessment of anxiety, in particular, via semi-structured interview. This may help to
distinguish between patients who are motivated by their anxiety to self-manage pain versus
patients whose anxiety serves as a risk factor for treatment non-adherence. This knowledge
can be used to tailor intervention in a way that more appropriately targets individual
requirements for effective chronic pain self-management.
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6.5 Limitations
Within Study Two and Study Three there were some limitations that were specific to
the design and some limitations that are more inherent in chronic pain research.
The main limitations of the present research are methodological in nature. In addition
to the cross-sectional design of Study Two preventing any causal inferences to be made, the
majority of participants in Studies Two and Three were female and presented with chronic
pain that was musculoskeletal in nature. Subsequently, results from these studies may lack
generalizability to the broader pain population, including various other pain localisations, and
warrant cautious interpretation. The issue of generalizability may be of particular concern if
certain beliefs are found to be more common among individuals with specific pain
localisations (e.g., fear-avoidance beliefs among chronic low back pain sufferers, Brox et al.,
2005). Therefore, interpretation of the relationships supported in Studies Two and Three may
be limited to similar samples of female predominant patients with chronic musculoskeletal
pain presentations.
There are also several limitations specific to Study Three. Firstly, there was a
significant participant attrition rate of approximately sixty four percent, despite efforts by the
research team to follow up participants. This involved contacting participants via telephone
with reminders if their questionnaires weren’t received. High attrition rates are a common
problem of longitudinal research and are well documented in samples of chronic pain patients
(Chiesa & Serretti, 2011; Solberg, Roach & Segerstrom, 2009). This is likely due to the
experience of chronic pain often being reported as persistently challenging, both physically
and emotionally. Replication of the present longitudinal study with a larger sample size is
warranted. However, careful consideration and planning of strategies to reduce attrition rates
at the outset are needed to curtail excessive study drop-out.
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Secondly, the wide variety of treatment approaches recommended to participants in
Study Three resulted in considerable heterogeneity when it came to comparing post-treatment
adherence. For example, adherence to physical exercise recommendations and to mood
management techniques would appear to be very different things. The finding that higher
pain-related self-efficacy and lower anxiety were general predictors of adherence to all these
different potential self-management behaviours leaves many unanswered questions. Future
research which disseminates these different potential pain management behaviours is crucial
to clarify the relative and specific importance of predictors of post-treatment adherence, in
particular, pain self-efficacy and anxiety. Considerable variation in the methods of assessing
other core constructs such as pain self-efficacy was also highlighted in Study 1 (e.g., Pain
Self-Efficacy Questionnaire, Arthritis Self-Efficacy Scale, Exercise Self-Efficacy
Questionnaire). This may have partly accounted for the differences among studies examining
the impact of pain self-efficacy on treatment adherence. Therefore, research aimed at
enhancing the consistency and comparability of research by intentionally utilising similar
methods of measurement would be beneficial.
Thirdly, the proposed predictors of post-treatment adherence included in Study Three
were measured at traditional time-points (pre- and post-intervention). It is possible that the
true effects of these variables were missed due to failing to measure at their appropriate time
of impact. To rectify this limitation for future research, more detailed measurement within
and beyond the treatment phase may help to clarify whether null findings are attributable to
issues of measurement timing or rather reflect the true nature of their influence on post-
treatment adherence.
A further limitation of the chronic pain literature in general is the self-report nature
that nearly all studies adopt. Although self-report is considered the gold standard of pain
measurement given its consistency with the ‘subjective’ definition of pain, limitations are
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inherent in the subjectivity of self-reported measures, such as ability to discern and
effectively communicate one’s pain state (Schiavenato & Kenneth, 2010). This brings a
fourth limitation of Study Three to light - the Treatment Maintenance Questionnaire (TMQ)
developed by the researchers of this study to measure post-treatment adherence. In addition to
the subjectiveness inherent in this self-report measure, it is also possible that the responses to
questions about adherence to treatment recommendations reflect social desirability biases
(van de Mortel, 2008). Subsequently, for a range of reasons (e.g., compensation, desire to be
perceived in a positive light), participants may be led to alter their true level of adherence to
impress their treating clinicians and/or stage improvements of pain characteristics and
associated outcomes. To mediate the limitations of self-report measures, inclusion of
professional assessment and interpretation of presenting psychological factors is
recommended. Another limitation of the TMQ relates to its scoring system. That is, patients
were instructed to score a zero on an item if they had not been recommended to use a
particular strategy (i.e., ‘0 – I was not recommended to use this strategy’). This led to
inherent challenges (in the form of time expenditure) in calculating an accurate total TMQ
score. To address the limitations of the TMQ, inclusion of more precise (e.g., ‘not
applicable’) and reverse-scored items assessing post-treatment adherence would be
beneficial. This may help to overcome time consuming scoring challenges in addition to
further reducing the likelihood of self-report biases; thus, improving the comparative validity
and reliability of this outcome measure.
6.6 Conclusions and future research
The overall aim of this thesis was to explore the associations between pain-related
beliefs, psychological presentations and treatment adherence in individuals experiencing
chronic pain. All three studies in this thesis have highlighted the importance of psychological
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factors on chronic pain outcomes and the need for future participants to be more thoroughly
screened for at-risk levels of these factors pre- and post-intervention. This is crucial in order
to improve and maintain treatment outcomes and thus, reduce the likelihood of relapse and
re-admission into Australian pain management programmes.
Findings for the three studies demonstrated the importance of several psychological
factors. Whereas, Study One showed pain self-efficacy to be the pain-related belief most
reliably implicated in treatment adherence outcomes, Study Two highlighted the importance
of pain self-efficacy for pain and affective disorder symptoms. Fear-avoidance beliefs and
perceived disability were also considered to be important constructs in Study Two. Study
Three indicated depression and fear-avoidance post-treatment to be important risk factors for
patient’s ability to adhere to treatment recommendations. Interestingly, Study Three also
found change in anxiety symptoms from pre-to post-intervention was found to conversely
predict post-intervention adherence. These findings are quite promising as pain self-efficacy,
depression, fear-avoidance beliefs, perceived disability as well as anxiety are all modifiable
and have been shown empirically to independently improve chronic pain outcomes when
modified through appropriate interventions (Börsbo, Gerdle & Peolsson, 2010; George et al.,
2010; Gockel, Lindholm, Niemistö & Hurri, 2008; Smeeding et al., 2010).
Collectively, the series of studies included in this thesis endeavoured to examine the
relationships between various psychological and cognitive factors on chronic pain outcomes,
in particular, post-treatment adherence. Specifically, Study Three contributed to the chronic
pain literature by highlighting which of these specific psychological factors, and at what
time-points, are most predictive of effective self-management post-treatment. This is
particularly important to enable clinicians to identify which specific variables to target and
when; thereby, increasing the likelihood of effective long-term self-management and, thus,
reducing rates of relapse and re-admission to chronic pain programmes. This research helps
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to justify the usefulness of PMPs whilst advocating for adequate economic support for future
programmes. However, to further assimilate the resource use and cost of such programmes,
future research in this field would benefit from the inclusion of a health economist. Future
longitudinal research might also consider the use of a mixed methods approach (e.g., in-depth
interviews, questionnaires) to provide insight into process data, thus, adding more value to
any quantitative findings. Similarly, clinicians should exercise caution in administering
'standard' assessments, instead, utilising mixed methods to achieve more accurate
formulations and subsequent treatment plans. This is important to uphold best practice and
patient-centred intervention. By ensuring thorough assessments of the subjective features of
chronic pain (e.g., understanding unique barriers and facilitators), treatment can be better
tailored to suit individual needs. Finally, future research is needed to expand on the findings
of this thesis, to improve upon the methodological limitations of the present research design
and further investigate the role that modifiable cognitive and psychological factors have on
post-treatment adherence and self-management behaviour.
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References
Alschuler, K. N., Theisen-Goodvich, M. E., Haig, A. J., & Geisser, M. E. (2008). A
comparison of the relationship between depression, perceived disability, and physical
performance in persons with chronic pain, Eur J Pain, 12, 757-764.
Asghari, A., Julaeiha, S., & Godarsi, M. (2008). Disability and depression in patients with
chronic pain: Pain or pain-related beliefs? Archives of Iranian Medicine, 11(3), 263-
269.
Bailey, K. M., Carleton, N., Vlaeyen, J. W. S., & Asmundson, G. J. G. (2010). Treatments
addressing pain-related fear and anxiety in patients with chronic musculoskeletal pain:
A preliminary review, Cognitive Behaviour Therapy, 39(1), 46-63.
Baker, T. A., Buchanan, N. T., & Corson, N. (2008). Factors influencing chronic pain
intensity in older black women: examining depression, locus of control, and physical
health, J Womens Health, 17, 869-878.
Bandura, A. (1977). Self-efficacy: Toward a unifying theory of behavioural change,
Psychological Review, 84(2), 191-215.
Berg, K. M., Cooperman, N. A., Newville, H., & Arnsten, J. H. (2009). Self-efficacy and
depression as mediators of the relationship between pain and antiretroviral adherence,
Aids Care, 21(2), 244-248.
Blashill, A. J., Perry, N., Safren, S. A. (2011). Mental health: A focus on stress, coping, and
mental illness as it relates to treatment retention, adherence, and other health
outcomes, Current HIV/AIDS Report, 8(4), 215-222.
![Page 210: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/210.jpg)
196
Börsbo, B., Gerdle, B., & Peolsson, M. (2010). Impact of the interaction between
selfefficacy, symptoms and catastrophizing on disability, quality of life and health in
chronic pain patients, Disability and Rehabilitation, 32(17), 1387-1396.
Brox, J. I., Storheim, K., Holm, I., Friis, A., & Reikeras, O. (2005). Disability, pain,
psychological factors and physical performance in healthy controls, patients with sub-
acute and chronic low back pain: A case-control study, Journal of Rehabilitation
Medicine, 37, 95-99.
Chiesa, A., & Serretti, A. (2011). Mindfulness-based interventions for chronic pain: A
systematic review of the evidence, The Journal of Alternative and Complimentary
Medicine, 17(1), 83-93.
Coppack, R. J., Kristensen, J., & Karaheorghis, C. I. (2012) Use of goal setting intervention
to increase adherence to low back pain rehabilitation: a randomized control trial,
Clinical Rehabilitation, 261032-1042.
Costa, L. C. M., Maher, C. G., McAuley, J. H., Hancock, M. J., & Smeets, R. J. E. M. (2011).
Self-efficacy is more important than fear of movement in mediating the relationship
between pain and disability in chronic low back pain, European Journal of Pain, 15,
213-219.
Crombez, G., Eccleston, C., Van Damme, S., Vlaeyen, J., & Karoly, P. (2012). Fear-
avoidance model of chronic pain: The next generation, The Clinical Journal of Pain,
28(6), 475-483.
Curran, C., Williams, A. C. C., & Potts, H. W. W. (2009). Cognitive-behavioral therapy for
persistent pain: does adherence after treatment affect outcome? European Journal of
Pain, 13,178-188.
![Page 211: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/211.jpg)
197
Dobkin, P. L., Abrahamowicz, M., Fitzcharles, M., Dritsa, M., & Costa, D. (2005).
Maintenance of exercise in women with fibromyalgia, Arthritis Rheumatology, 53,
724-731.
Dobkin, P. L., Liu, A., Abrahamowicz, M., Ionescu-Ittu, R., Bernatsky, S., Goldberger, A., &
Murray, B. (2010). Predictors of disability and pain six months after the end of
treatment for fibromyalgia, The Clinical Journal of Pain, 26(1), 23-29.
Engstrӧm, L. O., & Ӧberg, B. (2005). Patient adherence in an individualized rehabilitation
programme: a clinical follow-up. Scandinavian Journal of Public Health, 33, 11-18.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. S. (2007). The
biopsychosocial approach to chronic pain: Scientific advances and future directions,
Psychological Bulletin, 133(4), 581-624.
George, S. Z., Valencia, C., & Beneciuk, J. M. (2010). A psychometric investigation of fear-
avoidance model measures in patients with chronic low back pain, Journal of
Orthopaedic & Sports Physical Therapy, 40(4), 197-205.
Glombiewski, J. A., Hartwich-Tersek, J., & Rief, W. (2010). Attrition in cognitive-behavioral
treatment of chronic back pain, Clinical Journal of Pain, 26,593-601.
Gockel, M., Lindholm, H., Niemistö, L., & Hurri, H. (2008). Perceived disability but not pain
is connected with autonomic nervous function among patients with chronic low back
pain, Journal of Rehabilitation Medicine, 40, 355-358.
Goldberg, D. S., & McGee, S. J. (2011). Pain as a global public health priority, BMC Public
Health, 6(11), 1-5.
Gormsen, L., Rosenberg, R., Bach, F. W., & Jensen, T. S. (2010). Depression, anxiety,
health-related quality of life and pain in patients with chronic fibromyalgia and
neuropathic pain, Eur J Pain, 14(2), 127.e1-127.e8.
![Page 212: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/212.jpg)
198
Heapy, A., Otis, J., Marcus, K. S., Frantsve, L. M., Janke, A. E., Shulman, M., Bellmore, W.,
& Kerns, R. D. (2005). Intersession coping skill practice mediates the relationship
between readiness for self-management treatment and goal accomplishment, Pain,
118, 360-368.
Jack, K., McLean, S. M., Moffett, J. K., Gardiner, E. (2010). Barriers to treatment adherence
in physiotherapy outpatient clinics: A systematic review, Manual Therapy, 15(3),
220-228.
Jackson, T., Wang, Y., Wang, Y., & Fan, H. (2014). Self-efficacy and chronic pain outcomes:
A meta-analytic review, The Journal of Pain, 15(8), 800-814.
Lucchetti, G., Oliveira, A. B., Mercante, J. P. P., Peres, M. F. P. (2012). Anxiety and fear-
avoidance in musculoskeletal pain, Current Pain and Headache Reports, 16(5), 399-
406.
Maeda, U., Shen, B., Schwarz, E. R., Farrell, K. A., & Mallon, S. (2013). Self-efficacy
mediates the associations of social support and depression with treatment adherence
in heart failure patients. International Journal of Behavioral Medicine, 20(1), 88-96.
Manchikanti, L., Atluri, S., Trescot, A., & Giordano, J. (2008). Monitoring opioid adherence
in chronic pain patients: Tools, techniques and utility, Pain Physician, 11(1), 1-26.
Mannion, A. F., Helbling, D., Pulkovski, N., & Sprott, H. (2009). Spinal segmental
stabilisation exercises for chronic low back pain: programme adherence and its
influence on clinical outcome, European Spine Journal, 181881-1891.
McCracken, L. M., & Keogh, E. (2009). Acceptance, mindfulness, and values-based action
may counteract fear and avoidance of emotions in chronic pain: An analysis of
anxiety sensitivity, The Journal of Pain, 10(4), 408-415.
Nicholas, M. K. (1989). Self-efficacy and chronic pain. In: Paper presented at the annual
conference of the British Psychological Society, St Andrews, Scotland.
![Page 213: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/213.jpg)
199
Nicholas, M. K., Asghari, A., Corbett, M., Smeets, R. J. E. M., Wood, B. M., Overton, S.,
Perry, C., Tonkin, L. E., & Beeston, L. (2012). Is adherence to pain self-management
strategies associated with improved pain, depression and disability in those with
disabling chronic pain? European Journal of Pain, 16, 93-104.
Nicklas, L. B., Dunbar, M., & Wild, M. (2010). Adherence to pharmacological treatment of
non-malignant chronic pain: The role of illness perceptions and medication beliefs,
Psychology & Health, 25(5), 601-615.
Reser, J. P., & Muncer, S. (2004). Sense-making in the wake of September 11th: A network
analysis of lay understandings, British Journal of Psychology, 95(3), 283-296.
Richardson, E. J., Ness, T. J., Doleys, D. M., Baňos, J. H., Cianfrini, L., & Richards, J. S.
(2009). Depressive symptoms and pain evaluations among persons with chronic pain:
Catastrophizing, but not pain acceptance, shows significant effects, Pain, 147, 147-
152.
Robinson, M. E., Bulcourf, B., Atchison, J. W., Berger, J., Lafayette-Lucy, A., Hirsh, A. T.,
Riley, J. L. (2004). Compliance in pain rehabilitation: Patient and provider
perspectives, Pain Medicine, 5, 66-80.
Roditi, D., & Robinson, M. E. (2011). The role of psychological interventions in the
management of patients with chronic pain, Psychology Research and Behavior
Management, 4, 41-49.
Sardá Jr., J., Nicholas, M. K., Asghari, A., & Pimenta, C. A. M. (2009). The contribution of
self-efficacy and depression to disability and work status in chronic pain patients: A
comparison between Australian and Brazilian samples, European Journal of Pain, 13,
189-195.
Schiavenato, M., & Kenneth, C. D. (2010). Pain assessment as a social transaction: Beyond
the “gold standard”, Clinical Journal of Pain, 26(8), 667-676.
![Page 214: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/214.jpg)
200
Smeeding, S. J. W., Bradshaw, D. H., Kumpfer, K., Trevithick, S., & Stoddard, G, J. (2010).
Outcome evaluation of the veterans affairs salt lake city integrative health clinic for
chronic pain and stress-related depression, anxiety, and post-traumatic stress disorder,
The journal of Alternative and Complementary Medicine, 16(8), 823-835.
Solberg, L., Roach, A. R., & Segerstrom, S. C. (2009). Executive functions, self-regulation,
and chronic pain: A review, Annual Behavioural Medicine, 37, 173-183.
Turk, D. C., Wilson, H. D., & Cahana, A. (2011). Treatment of chronic non-cancer pain,
Lancet, 377, 2226-2235.
van de Mortel, T. F. (2008). Faking it: social desirability response bias in self-report research,
Australian Journal of Advanced Nursing, 25(4), 40-48.
Wideman, T. H., Adams, H., Sullivan, M. J. L. (2009). A prospective sequential analysis of
the fear-avoidance model of pain, Pain, 145, 45-51.
Yazdi-Ravandi, S., Taslimi, Z., Jamshidian, N., Saberi, H., Shams, J., & Haghparast, A.
(2013). Prediction of quality of life by self-efficacy, pain intensity and pain duration
in patient with pain disorders, Basic and Clinical Neuroscience, 4(2), 117-124.
![Page 215: Psychological Correlates of Chronic Pain and …dro.deakin.edu.au/eserv/DU:30105488/thompson...involved in chronic pain outcomes, in particular, treatment adherence. Study One was](https://reader035.vdocument.in/reader035/viewer/2022070916/5fb6b5bea19cc77f1e3276c4/html5/thumbnails/215.jpg)
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Appendix A: Deakin University Human Research Ethics Committee ethics approval
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Appendix D: Plain Language Statement for Study Two
TITLE OF THE STUDY:
“A retrospective analysis of pain characteristics, demographics, functioning, & mental health
symptoms in adults who have attended the Pain Management Clinic at The Victorian
Rehabilitation Centre”
PURPOSE OF THE STUDY:
Research findings from overseas (especially the U.S. and U.K.) have led to the current
best practice clinical guidelines for the treatment of Chronic Pain which are now used in
Australia. These guidelines recommend that healthcare professionals should look out for
‘risk factors’ which might make management of Chronic Pain more difficult for sufferers
(including biological, psychological and social issues). They also recommend that part of the
treatment for people with Chronic Pain should be to try to help sufferers recognise and
change some of these risk factors if it is possible (e.g. helping to change negative perceptions
of disability, fears about movement, low self confidence in managing pain, and emotional
distress).
However, there has been very little research done in this area specifically with
Australian sufferers, presenting at a service such as the Pain Management Clinic at The
Victorian Rehabilitation Centre. Although there are many similarities between Australian and
U.S. and U.K. populations, there are also some differences - particularly regarding the
medical and legal systems.
The purpose of this study is to discover whether the same risk factors are important for
an Australian population of Chronic Pain sufferers, which would assist us in
determining whether the current best practice guidelines are appropriate.
METHODS USED IN THE STUDY:
Should you choose to participate in this project the researchers will enter your
information from your hospital file into a secure database. You do not need to complete
any new information.
However, in order for us to be able to use your information, you must sign and return the
attached consent form using the enclosed reply paid envelope. This information will then
be used to write publications for scientific journals or conferences.
The information that is entered into the secure database will be ‘de-identified’, meaning that
instead of including names and addresses, the data will be attached to a code and names will
be removed prior to the research team accessing the data. We are coding the data, in case we
need to add any follow up information that we may collect from you at a later date. The
coded data will be kept in a secure, locked location at The Victorian Rehabilitation Centre, in
a similar way to which patient’s hospital files are stored, and will be kept for a minimum of
10 years before being securely destroyed.
The computer database will only be accessible to members of the research team, including
Dr. M. Bertino, Ms. R. Kovacevic, Ms. M. Sandilands, Ms. D. Zammit, Ms. A. Newbigin,
Ms. E. Ahmet, Dr. J. Broadbent, Ms E. Thompson and supervised, trained research assistants.
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The information that will be accessed and entered into the secure database will include:
your demographics (age, gender, insurer, referral source) completed at the time of
assessment, questionnaires that you completed when attending the centre (relating to mental
health, functioning, pain attitudes beliefs and responses, medications, and services received),
and information from the initial assessment interview form that was completed by the
clinicians during your assessment interview (relating to primary concerns at the time, pain
severity rating, mental health symptoms, mental health history and diagnoses, work history,
social supports, and coping strategies).
Names, addresses or contact details will NOT be entered into the research database. In
writing any publications from the data, the research team will only use participant’s data
in a combined form with other participant’s data, so that individual identities cannot be
determined by the readers of the publications.
DEMANDS OF THE STUDY:
To complete and return the attached consent form using the enclosed reply paid
envelope, should you wish to participate in this project. This will allow the researchers to
access the information specified above from your medical file, under the above conditions. If
you change your mind, you may withdraw your consent to participate at any time prior to
publication of the results by contacting the researchers (Phone 0395018785).
COMPLAINTS:
If you have any complaints about any aspect of the project, the way it is being conducted or
any questions about your rights as a research participant, then you may contact: The
Manager, Research Integrity, Deakin University, 221 Burwood Highway, Burwood Victoria
3125, Telephone: 9251 7129, Facsimile: 9244 6581; [email protected].
Please quote project number: 2012-147.
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Appendix E: Consent form Study Two
CONSENT FORM
FOR INVOLVEMENT OF PARTICIPANTS IN MEDICAL RESEARCH
at The Victorian Rehabilitation Centre
Approved by The Melbourne Clinic Research Ethics Committee
I agree to participate in a research project entitled “A retrospective analysis of pain
characteristics, demographics, functioning, and mental health symptoms in adults who have
attended the Pain Management Clinic at the Victorian Rehabilitation Centre”
This research is being conducted by Dr. Melanie Bertino, Ms. Rachel Kovacevic, Ms. Mary
Sandilands, Ms. Denise Zammitt, Ms. Emel Ahmet, and Ms. Amanda Newbigin, psychologists
at the Victorian Rehabilitation Centre, in collaboration with researchers at Deakin University,
Dr. Jaclyn Broadbent (lecturer) and Ms. Emma Thompson (Doctor of Health Psychology
Student).
1. My agreement is based on the understanding that:
My involvement entails me posting back this signed consent form using the reply-paid
envelope. This will allow the researchers to access de-identified information from my
hospital record and enter it into a computer database (de-identified meaning that instead
of using my name, my data will be attached to a code to protect my privacy). The computer
database will only be accessible to members of the research team, including the above-named
psychologists and supervised, trained research assistants.
My information that will be entered will include: demographics (age, gender, insurer, referral
source), questionnaires (mental health, functioning, pain attitudes beliefs and responses,
medications, services received), and the initial assessment interview form from my assessment
interview (primary concerns, pain severity rating, mental health symptoms, mental health
history and diagnoses, work history, social supports, and coping strategies).
My name, address or contact details will NOT be entered into the research database. In writing
any publications from the data, the research team will only use my data in a combined form
with other participants’ data, so that my identity cannot be determined by the audience of the
publication.
2. The following risks, discomforts and inconveniences have been explained to me:
No adverse outcomes are expected from your participation in this project. Should you have any
concerns regarding this project, please contact Dr. Melanie Bertino in the first instance on:
(03)95018785. Alternatively, please contact the Melbourne Clinic Research Ethics Committee
Research Manager (Professorial Unit), Deidre Smith, on: (03)94209353.
If you have any complaints about any aspect of the project, the way it is being conducted or
any questions about your rights as a research participant, then you may contact: The
Manager, Research Integrity, Deakin University, 221 Burwood Highway, Burwood Victoria
3125, Telephone: 9251 7129, Facsimile: 9244 6581; [email protected].
Please quote project number: 2012-147
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3. I have read the attached “Information Sheet” and understand the general purposes, methods
and demands of the project.
4. I understand that the project may not be of direct benefit to me.
5. I can withdraw my data from the project at any time prior to the results being published. In
order to withdraw my consent I should contact Dr Melanie Bertino on (03)95662939. This will
not affect any further therapy or relationships with staff at The Victorian Rehabilitation Centre
in any way.
6. I am satisfied with the explanation given in relation to the project in so far as it affects me.
7. My consent to participate in this project is given freely.
8. I have been informed that the information I provide will be confidential.
.....................................................................................................................................
(Name of participant)
SIGNED ..................................................................... DATE ...................................
(Participant)
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Appendix F: Network map without anxiety symptoms for Study Two
Once anxiety is excluded from the model, depression drops from the node (variable) with the
highest strength value to third highest. Its betweenness value also dropped as it was no longer
bridging other variables with anxiety. Depressive symptoms retained direct links with
control, avoidance, and self-efficacy, as per the original model. In this revised model, there is
still no direct link between pain intensity and depression, ruling out the possibility that the
lack of direct association in the original model was due to heavy overlap between depression
and anxiety symptoms.
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Appendix H: Plain Language Statement for Study Three
TITLE OF THE STUDY:
“A retrospective analysis of pain characteristics, demographics, functioning, & mental health
symptoms in adults who have attended the Pain Management Clinic at The Victorian
Rehabilitation Centre”
PURPOSE OF THE STUDY:
The researchers of this study are interested in obtaining follow-up information about the
effectiveness of Chronic Pain treatment interventions on patient outcomes over time.
Research findings from overseas (especially the U.S. and U.K.) have led to the current best
practice clinical guidelines for the treatment of Chronic Pain which are now used in
Australia. These guidelines recommend that healthcare professionals should look out for ‘risk
factors’ which might make management of Chronic Pain more difficult for sufferers (including
biological, psychological and social issues). They also recommend that part of the treatment for
people with Chronic Pain should be to try to help sufferers recognise and change some of these
risk factors if it is possible (e.g. helping to change negative perceptions of disability, fears about
movement, low self confidence in managing pain, and emotional distress).
However, there has been very little research done in this area specifically with Australian
sufferers, presenting at a service such as the Pain Management Clinic at The Victorian
Rehabilitation Centre. Although there are many similarities between Australian and U.S. and
U.K. populations, there are also some differences - particularly regarding the medical and legal
systems.
The purpose of this study is to discover whether the same risk factors are important for an
Australian population of Chronic Pain sufferers, which would assist us in determining
whether the current best practice guidelines are appropriate.
METHODS USED IN THE STUDY:
Should you choose to participate in this study, you need to complete and return the
questionnaire booklet enclosed. This questionnaire booklet contains the same battery of
measures that you completed at the beginning of treatment and one additional measure
entitled ‘Treatment Maintenance Questionnaire’.
However, in order for us to be able to use your information from the questionnaire booklet, you
must sign and return the attached consent form using the reply-paid envelope provided.
This information will then be used to write publications for scientific journals or conferences.
The information that is entered into the secure database will be ‘de-identified’, meaning that
instead of including names and addresses, the data will be attached to a code and names will be
removed prior to the research team accessing the data. We are coding the data, in case we need to
add any follow up information that we may collect from you at a later date. The coded data will
be kept in a secure, locked location at The Victorian Rehabilitation Centre, in a similar way to
which patient’s hospital files are stored, and will be kept for a minimum of 10 years before being
securely destroyed.
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The computer database will only be accessible to members of the research team, including Dr.
M. Bertino, Ms. R. Kovacevic, Ms. M. Sandilands, Ms. D. Zammit, Ms. A. Newbigin, Ms. E.
Ahmet, Dr. J. Broadbent, Ms E. Thompson and supervised, trained research assistants. The new
information that will be entered into the secure database will include your responses in the
questionnaire booklet.
Names, addresses or contact details will NOT be entered into the research database. In writing
any publications from the data, the research team will only use participant’s data in a
combined form with other participant’s data, so that individual identities cannot be
determined by the readers of the publications.
DEMANDS OF THE STUDY:
To complete and return the attached consent form and questionnaire booklet using the
enclosed reply paid envelope, should you wish to participate in this project. This will allow
the researchers to include the information specified above, under the above conditions. If you
change your mind, you may withdraw your consent to participate at any time prior to publication
of the results by contacting the researchers (Phone 03 9566 2777).
COMPLAINTS:
If you have any complaints about any aspect of the project, the way it is being conducted or
any questions about your rights as a research participant, then you may contact: The
Manager, Research Integrity, Deakin University, 221 Burwood Highway, Burwood Victoria
3125, Telephone: 9251 7129, Facsimile: 9244 6581; [email protected].
Please quote project number: 2012-147.
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Appendix I: Consent form for Study 3
CONSENT FORM
FOR INVOLVEMENT OF PARTICIPANTS IN MEDICAL RESEARCH
at The Victorian Rehabilitation Centre
Approved by The Melbourne Clinic Research Ethics Committee
I agree to participate in a follow-up study for the research project entitled “A retrospective analysis
of pain characteristics, demographics, functioning, and mental health symptoms in adults who
have attended the Pain Management Clinic at the Victorian Rehabilitation Centre”
This research is being conducted by Melanie Bertino, Rachel Kovacevic, Mary Sandilands, Denise
Zammitt, Emel Ahmet, and Amanda Newbigin, psychologists at the Victorian Rehabilitation
Centre, in collaboration with researchers at Deakin University, Jaclyn Broadbent (lecturer) and
Emma Thompson (Doctor of Health Psychology Student).
3. My agreement is based on the understanding that:
My involvement entails me posting back this signed consent form and questionnaire booklet
using the reply-paid envelope. This questionnaire booklet will not contain any identifying
information other than a code used to match this data to your previous data. This is known
as de-identified data (de-identified meaning that instead of using my name, my data will be
attached to a code to protect my privacy). The computer database will only be accessible to
members of the research team, including the above-named psychologists and supervised, trained
research assistants.
My name, address or contact details will NOT be entered into the research database. In writing any
publications from the data, the research team will only use my data in a combined form with other
participants’ data, so that my identity cannot be determined by the audience of the publication.
4. The following risks, discomforts and inconveniences have been explained to me:
No adverse outcomes are expected from your participation in this project. Should you have any
concerns regarding this project, please contact Dr. Melanie Bertino in the first instance on:
95018785. If you are distressed in any way by the research procedures used in this project, please
contact Dr. Simone Fisher on: 95018791, a clinician who is not a member of the research team.
If you have any complaints about any aspect of the project, the way it is being conducted or
any questions about your rights as a research participant, then you may contact: The Chair of
the Melbourne Clinic Research Ethics Committee, Dr Harry Derham, Telephone: 9420 9350.
Or the Manager, Research Integrity, Deakin University, 221 Burwood Highway, Burwood
Victoria 3125, Telephone: 9251 7129, Facsimile: 9244 6581; research-
[email protected]. Please quote project number: 2012-147
3. I have read the attached “Information Sheet” and understand the general purposes, methods
and demands of the project.
4. I understand that the project may not be of direct benefit to me.
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5. I can withdraw my data from the project at any time prior to the results being published. In
order to withdraw my consent, I should contact Melanie Bertino on 95018785. This will
not affect any further therapy or relationships with staff at The Victorian Rehabilitation
Centre in any way.
6. I am satisfied with the explanation given in relation to the project in so far as it affects me.
7. My consent to participate in this project is given freely.
8. I have been informed that the information I provide will be confidential.
NAME .....................................................................................................................................
SIGNED ..................................................................... DATE ...................................
(Participant)
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Appendix J: Battery of questionnaires for Studies Two and Three
PSYCHOLOGICAL QUESTIONNAIRES FOR PAIN MANAGEMENT
Name
Date
Everyone who attends for pain assessment at The Victorian Rehabilitation Centre is asked to complete these questionnaires as a standard part of the assessment and programme. Your responses to these questionnaires provide information about your pain and how it impacts on your life. Please complete the questionnaires in this booklet by yourself, and answer every question. There are no “trick questions”, and no answers are either “wrong” or “right”.
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DASS-21
Lovibond & Lovibond (1995) Please read each statement and circle a number – 0, 1, 2 or 3 – which indicates how much the statement applied to you over the past week. There are no right or wrong answers. Do not spend too much time on any statement.
The rating scale is as follows:
0 Did not apply to me at all 1 Applied to me to some degree, or some of the time 2 Applied to me to a considerable degree, or a good part of time 3 Applied to me very much, or most of the time
1. I found it hard to wind down 0 1 2 3
2. I was aware of dryness of my mouth 0 1 2 3
3. I couldn’t seem to experience any positive feeling at all 0 1 2 3
4. I experienced breathing difficulty (eg: excessively rapid breathing, 0 1 2 3 breathlessness in the absence of physical exertion)
5. I found it difficult to work up the initiative to do things 0 1 2 3
6. I tended to over-react to situations 0 1 2 3
7. I experienced trembling (eg: in the hands) 0 1 2 3
8. I felt that I was using a lot of nervous energy 0 1 2 3
9. I was worried about situations in which I might panic 0 1 2 3 and make a fool of myself
10. I felt that I had nothing to look forward to 0 1 2 3
11. I found myself getting agitated 0 1 2 3
12. I found it difficult to relax 0 1 2 3
13. I felt down-hearted and blue 0 1 2 3
14. I was intolerant of anything that kept me from getting on 0 1 2 3 with what I was doing
15. I felt I was close to panic 0 1 2 3
16. I was unable to become enthusiastic about anything 0 1 2 3
17. I felt I wasn’t worth much as a person 0 1 2 3
18. I felt I was rather touchy 0 1 2 3
19. I was aware of the action of my heart in the absence of physical 0 1 2 3 exertion (eg: sense of heart rate increase, heart missing a beat)
20. I felt scared without any good reason 0 1 2 3
21. I felt that life was meaningless 0 1 2 3
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PSEQ Nicholas (1988)
Please rate how confident you are that you can do the following things at present despite the pain. To indicate your answer circle one of the numbers on the scale under each item, where 0 = not at all confident and 6 = completely confident. Remember, this questionnaire is not asking whether or not you have been doing these things, but rather how confident you are that you can do them at present, despite the pain.
1. I can enjoy things, despite the pain.
0 1 2 3 4 5 6 Not at all confident Completely confident
2. I can do most of the household chores (eg: tidying-up, washing dishes) despite the pain.
0 1 2 3 4 5 6 Not at all confident Completely confident
3. I can socialise with my friends or family as often as I used to do, despite the pain.
0 1 2 3 4 5 6 Not at all confident Completely confident
4. I can cope with my pain in most situations.
0 1 2 3 4 5 6 Not at all confident Completely confident
5. I can do some form of work, despite the pain. (housework, paid and unpaid work).
0 1 2 3 4 5 6 Not at all confident Completely confident 6. I can still do many of the things I enjoy doing (hobbies or leisure), despite the pain.
0 1 2 3 4 5 6 Not at all confident Completely confident 7. I can cope with my pain without medication.
0 1 2 3 4 5 6 Not at all confident Completely confident 8. I can still accomplish most of my goals in life, despite the pain.
0 1 2 3 4 5 6 Not at all confident Completely confident 9. I can live a normal lifestyle, despite the pain. 0 1 2 3 4 5 6 Not at all confident Completely confident
10. I can gradually become more active, despite the pain.
0 1 2 3 4 5 6 Not at all confident Completely confident
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PDI The rating scales below are designed to measure the degree to which several aspects of your life are presently disrupted by chronic pain. In other words, we would like to know how much your pain is preventing you from doing what you would normally do, or from doing it as well as you normally would. Respond to each category by indicating the overall impact of pain in your life, not just when the pain is at its worst. For each of the 6 categories of life activity listed, please circle the number on the scale which describes the level of disability you typically experience. A score of 0 means no disability at all, and a score of 10 signifies that all of the activities in which you would normally be involved have been totally disrupted or prevented by your pain.
Family / Home Responsibilities
This category refers to activities related to the home or family. It includes chores or duties performed around the house (eg: yard work) and errands or favours for other family members (eg: driving the children to school).
0 1 2 3 4 5 6 7 8 9 10
No disability Worst disability
Recreation
This category includes hobbies, sports, and other similar leisure time activities.
0 1 2 3 4 5 6 7 8 9 10
No disability Worst disability
Social Activity
This category refers to activities that involve participation with friends and acquaintances other than family members. It includes parties, theatre, concerts, dining out, and other social functions.
0 1 2 3 4 5 6 7 8 9 10
No disability Worst disability
Occupation
This category refers to activities that are a part of or directly related to one’s job. This includes non-paying jobs as well, such as that of a housewife or volunteer worker.
0 1 2 3 4 5 6 7 8 9 10
No disability Worst disability
Sexual Behaviour
This category refers to the frequency and quality of one’s sex life.
0 1 2 3 4 5 6 7 8 9 10
No disability Worst disability
Life Support Activity
This category refers to basic life-supporting behaviours such as eating, sleeping and breathing.
0 1 2 3 4 5 6 7 8 9 10
No disability Worst disability
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THE TAMPA SCALE Miller, Kori & Todd (1991)
In these days of high-tech medicine, one of the most important sources of information about you is often missing from your medical records: your own feelings or intuitions about what is happening with your body. We hope that the following information will help to fill that gap. Please answer the following questions according to the scale on the right. Please answer according to your true feelings, not according to what others think you should believe. This is not a test of medical knowledge; we want to know how you see it. Circle the number next to each question that best corresponds to how you feel.
The rating scale is as follows: 1. Strongly disagree 2. Somewhat disagree 3. Somewhat agree 4. Strongly agree
1. I’m afraid that I might injure myself if I exercise 1 2 3 4
2. If I were to try to overcome it, my pain would increase 1 2 3 4
3. My body is telling me I have something dangerously wrong 1 2 3 4
4. My pain would probably be relieved if I were to exercise 1 2 3 4
5. People aren’t taking my medical condition seriously enough 1 2 3 4
7. My accident has put my body at risk for the rest of my life 1 2 3 4
7. Pain always means I have injured by body 1 2 3 4
8. Just because something aggravates my pain does not mean 1 2 3 4 it is dangerous
9. I am afraid that I might injure myself accidentally 1 2 3 4
10. Simply being careful that I do not make any unnecessary movements 1 2 3 4 is the safest thing I can do to prevent my pain from worsening
11. I wouldn’t have this much pain if there weren’t something 1 2 3 4 potentially dangerous going on in my body
12. Although my condition is painful, I would be better off if I were 1 2 3 4 physically active
13. Pain lets me know when to stop exercising so that I don’t injure 1 2 3 4 myself
14. It’s really not safe for a person with a condition like mine to be 1 2 3 4 physically active
15. I can’t do all the things normal people do because it’s too easy 1 2 3 4 for me to get injured 16. Even though something is causing me a lot of pain, I don’t think 1 2 3 4 it’s actually dangerous
17. No one should have to exercise when s/he is in pain 1 2 3 4
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Survey of Pain Attitudes – Revised (SOPA-R)
Please indicate how much you agree with each of the following statements about your pain problem by using the response key below.
Response Key : 0 = This is very untrue for me 1 = This is somewhat untrue for me 2 = This is neither true nor untrue for me (or it does not apply to me) 3 = This is somewhat true for me 4 = This is very true for me
1. The pain I feel is a sign that damage is being done 0 1 2 3 4 2. I will probably always have to take pain medications 0 1 2 3 4
3. When I hurt, I want my family to treat me better 0 1 2 3 4
4. If my pain continues at this present level, I will be unable to work 0 1 2 3 4
5. The amount of pain I feel is out of my control 0 1 2 3 4
6. I do not expect a medical cure for my pain 0 1 2 3 4
7. Pain does not have to mean that my body is being harmed 0 1 2 3 4
8. I have had the most relief from pain with the use of medications 0 1 2 3 4
9. Anxiety increases the pain I feel 0 1 2 3 4
10. There is little that I can do to ease my pain 0 1 2 3 4
11. When I am hurting, I deserve to be treated with care and concern 0 1 2 3 4
12. I pay doctors so they will cure me of my pain 0 1 2 3 4
13. My pain problem does not need to interfere with my activity level 0 1 2 3 4
14. It is the responsibility of my family to help me when I feel pain 0 1 2 3 4
15. Stress in my life increases the pain I feel 0 1 2 3 4
16. Exercise and movement are good for my pain problem 0 1 2 3 4
17. Medicine is one of the best treatments for chronic pain 0 1 2 3 4
18. My family needs to learn how to take better care of me when I am
in pain 0 1 2 3 4
19. Depression increases the pain I feel 0 1 2 3 4
20. If I exercise, I could make my pain problem much worse 0 1 2 3 4
21. I can control my pain by changing my thoughts 0 1 2 3 4
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22. I need more tender loving care than I am now getting when I am in pain
0 1 2 3 4
23. I consider myself to be disabled 0 1 2 3 4
24. I have learned to control my pain 0 1 2 3 4
25. I trust that doctors can cure my pain 0 1 2 3 4
26. My pain does not stop me from leading a physically active life 0 1 2 3 4
27. My physical pain will never be cured 0 1 2 3 4
28. There is a strong connection between my emotions and my pain level
0 1 2 3 4
29. I am not in control of my pain 0 1 2 3 4
30. No matter how I feel emotionally, my pain stays the same 0 1 2 3 4
31. When I find the right doctor, he or she will know how to reduce my pain
0 1 2 3 4
32. If my doctor prescribed pain medications for me, I would throw them away
0 1 2 3 4
33. I will never take pain medications again 0 1 2 3 4
34. Exercise can decrease the amount of pain I experience 0 1 2 3 4
35. My pain would stop anyone from leading an active life 0 1 2 3 4
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Appendix K: Treatment Maintenance Questionnaire for Study Three
Treatment Maintenance Questionnaire
From our records, you attended a pain program at [Name of clinic omitted to maintain
anonymity during review process] in . During this program, you may have received
physiotherapy/exercise physiology, psychology, occupational therapy and/or hydrotherapy.
Please place a tick in the boxes next to the treatment that you received. You may answer
more than once.
Physiotherapy/Exercise Physiology
Psychology
Occupational Therapy
Hydrotherapy
When you attended this program it may have been recommended that you continue to
perform certain strategies to manage your pain symptoms after treatment. Please read the
following list of strategies and circle a number 0, 1, 2, 3, or 4 which indicates how often you
currently perform them. There are no right or wrong answers.
The rating scale is as follows: 0 I was not recommended to use this strategy
1 I do not use this strategy
2 I use this strategy some of the time
3 I use this strategy most of the time
4 I use this strategy all of the time
1. Regular exercise
a) Stretching
0 1 2 3 4
b) Walking
0 1 2 3 4
c) Resistance
0 1 2 3 4
2. Biomechanics
a) Moving correctly 0 1 2 3 4
b) Lifting correctly 0 1 2 3 4
c) Sitting/standing postures 0 1 2 3 4
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3. Relaxation techniques
a) Breathing 0 1 2 3 4
b) Mindfulness 0 1 2 3 4
c) Progressive/deep muscle relaxation 0 1 2 3 4
4. Activity pacing
a) Breaking up tasks 0 1 2 3 4
b) Taking rest breaks 0 1 2 3 4
c) Planning ahead 0 1 2 3 4
5. Stress and mood management
a) Identifying stressors 0 1 2 3 4
b) Problem solving 0 1 2 3 4
c) Challenge unhelpful thoughts 0 1 2 3 4
d) Pleasant activity scheduling 0 1 2 3 4
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Appendix L: Glossary of definitions
Anxiety Feelings of worry, nervousness, or unease about something
with an uncertain outcome
Catastrophising The tendency to exaggerate and ruminate negative cognitions
and emotions during actual or perceived painful stimulation
Depression Feelings of severe despondency and dejection
Fear-avoidance An irrational and debilitating fear of physical movement and
activity resulting from a feeling of vulnerability to painful
(re)injury
Pain intensity The sensation of physical hurt or discomfort
Pain self-efficacy Confidence in one’s ability to perform a range of activities
while in pain
Perceived control The belief that one can control their own pain experience
Perceived disability The impact that pain has on the ability of a person to participate
in essential life activities
Treatment maintenance Adherence behaviour to post-intervention recommendations