1 Psychological Health-Brief Symptom Inventory-18: All cancers

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 19973 1426 8.2 1172 6.8 1518 8.8 1814 10.5

Age at baseline 18-19 2155 101 7.1 85 6.0 105 7.4 139 9.8

20-24 6010 419 8.2 318 6.2 403 7.9 563 11.0

25-29 5553 412 8.3 359 7.3 430 8.7 520 10.5

30-34 3865 299 8.3 246 6.8 352 9.8 378 10.5

35+ 2390 195 8.6 164 7.2 228 10.0 214 9.4

Years since diagnosis 5-9 998 45 8.9 41 8.1 56 11.1 60 11.9

10-14 4900 327 7.9 274 6.6 335 8.1 471 11.3

15-19 7562 545 8.2 444 6.7 571 8.6 658 9.9

20+ 6513 509 8.5 413 6.9 556 9.2 625 10.4

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

2 Psychological Health-Brief Symptom Inventory-18: All cancers

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 1161 116 10.4 86 7.7 143 12.8 119 10.7

Years since diagnosis 5-9 447 18 7.5 16 6.7 31 13.0 20 8.4

10-14 2257 162 8.1 122 6.1 209 10.5 206 10.3

15-19 3579 281 8.7 226 7.0 364 11.2 301 9.3

20+ 3031 265 9.3 196 6.9 323 11.3 277 9.7

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

3 Psychological Health-Brief Symptom Inventory-18: All leukemias

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 5639 419 8.5 364 7.4 405 8.2 528 10.7

Age at baseline 18-19 844 37 6.5 33 5.8 39 6.9 54 9.5

20-24 1964 167 9.7 133 7.8 131 7.6 204 11.9

25-29 1598 130 8.8 122 8.2 132 8.9 158 10.7

30-34 837 60 7.6 53 6.7 66 8.3 80 10.1

35+ 396 25 6.6 23 6.1 37 9.8 32 8.4

Years since diagnosis 5-9 252 14 10.5 13 9.8 12 9.0 19 14.3

10-14 1290 90 8.4 73 6.8 87 8.1 126 11.7

15-19 2281 167 8.2 148 7.3 162 8.0 201 9.9

20+ 1816 148 8.7 130 7.7 144 8.5 182 10.7

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

4 Psychological Health-Brief Symptom Inventory-18: All leukemias

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Years since diagnosis 5-9 113 5 7.7 5 7.7 6 9.2 5 7.7

10-14 595 44 8.7 31 6.1 60 11.8 59 11.6

15-19 1109 100 9.9 88 8.7 115 11.4 105 10.4

20+ 841 77 9.6 59 7.4 88 11.0 84 10.5

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

5 Psychological Health-Brief Symptom Inventory-18: ALL

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 4675 347 8.4 304 7.4 331 8.0 445 10.8

Age at baseline 18-19 730 33 6.6 28 5.6 33 6.6 49 9.7

20-24 1687 142 9.4 116 7.7 115 7.6 177 11.7

25-29 1329 108 8.7 106 8.6 111 9.0 134 10.8

30-34 649 48 7.8 39 6.3 52 8.5 64 10.4

35+ 280 16 6.0 15 5.6 20 7.5 21 7.8

Years since diagnosis 5-9 186 13 11.8 11 10.0 10 9.1 16 14.5

10-14 1060 70 8.0 62 7.1 69 7.9 99 11.3

15-19 1903 141 8.2 124 7.2 135 7.9 173 10.1

20+ 1526 123 8.6 107 7.4 117 8.1 157 10.9

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

6 Psychological Health-Brief Symptom Inventory-18: ALL

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

10-14 475 36 8.9 26 6.4 47 11.6 43 10.6

15-19 911 82 9.7 71 8.4 96 11.4 88 10.4

20+ 700 65 9.7 51 7.6 70 10.5 74 11.0

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

7 Psychological Health-Brief Symptom Inventory-18: AML

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 697 53 9.0 43 7.3 52 8.8 63 10.7

Age at baseline 18-19 89 2 3.7 4 7.4 4 7.3 3 5.5

20-24 199 21 14.2 14 9.5 12 8.1 23 15.5

25-29 200 16 8.6 11 5.9 15 8.1 19 10.3

30-34 133 8 6.2 8 6.2 10 7.7 10 7.7

35+ 76 6 8.3 6 8.2 11 15.3 8 11.0

Years since diagnosis 5-9 37 1 5.0 2 10.0 1 5.0 3 15.0

10-14 166 15 10.3 8 5.5 16 11.0 19 13.0

15-19 294 20 8.2 18 7.4 16 6.6 22 9.0

20+ 200 17 9.4 15 8.3 19 10.5 19 10.5

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

8 Psychological Health-Brief Symptom Inventory-18: AML

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

15-19 159 14 10.6 14 10.5 12 9.1 13 9.8

20+ 104 7 7.2 5 5.2 12 12.4 8 8.2

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

9 Psychological Health-Brief Symptom Inventory-18: All CNS

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 3537 237 8.4 168 6.0 259 9.2 330 11.7

Age at baseline 18-19 377 19 8.5 11 4.9 18 8.0 24 10.6

20-24 1179 70 7.7 57 6.3 75 8.2 98 10.7

25-29 1084 71 8.0 49 5.5 66 7.4 114 12.9

30-34 623 53 9.6 37 6.7 69 12.5 66 12.0

35+ 274 24 9.7 14 5.7 31 12.6 28 11.3

Years since diagnosis 5-9 174 7 8.0 6 6.9 11 12.6 9 10.3

10-14 962 55 7.2 45 5.9 58 7.5 86 11.2

15-19 1329 99 9.1 68 6.3 97 8.9 130 11.9

20+ 1072 76 8.7 49 5.6 93 10.6 105 12.0

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

10 Psychological Health-Brief Symptom Inventory-18: All CNS

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 125 15 13.3 8 7.1 19 16.8 15 13.3

Years since diagnosis 5-9 74 5 12.8 4 10.3 7 17.9 5 12.8

10-14 446 26 7.0 18 4.8 37 9.9 41 11.0

15-19 607 43 8.4 30 5.9 63 12.3 50 9.7

20+ 487 37 9.1 19 4.7 55 13.5 45 11.0

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

11 Psychological Health-Brief Symptom Inventory-18: Astrocytomas

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 2160 157 8.8 112 6.3 174 9.7 209 11.7

Age at baseline 18-19 215 13 9.2 6 4.2 11 7.7 19 13.4

20-24 713 53 9.2 43 7.4 54 9.3 66 11.4

25-29 664 46 8.3 33 6.0 44 7.9 67 12.1

30-34 386 28 8.0 20 5.7 44 12.6 37 10.6

35+ 182 17 10.1 10 6.0 21 12.5 20 11.9

Years since diagnosis 5-9 96 6 12.0 4 8.0 8 16.0 6 12.0

10-14 570 42 9.0 35 7.5 40 8.6 59 12.6

15-19 780 55 8.2 36 5.4 57 8.5 73 10.9

20+ 714 54 9.0 37 6.1 69 11.4 71 11.8

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

12 Psychological Health-Brief Symptom Inventory-18: Astrocytomas

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 85 11 13.6 6 7.4 13 16.0 12 14.8

Years since diagnosis 5-9 46 4 16.7 3 12.5 6 25.0 4 16.7

10-14 269 18 7.8 14 6.1 23 10.0 27 11.7

15-19 384 28 8.3 20 6.0 39 11.5 31 9.2

20+ 335 27 9.3 15 5.2 41 14.2 32 11.1

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

13 Psychological Health-Brief Symptom Inventory-18: Medulloblastoma/PNET

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 794 41 7.2 33 5.8 38 6.7 72 12.7

Age at baseline 18-19 83 2 5.3 2 5.3 1 2.6 1 2.5

20-24 291 9 4.5 8 4.0 8 4.0 21 10.6

25-29 252 16 8.2 10 5.2 15 7.7 33 17.0

30-34 131 13 12.3 11 10.3 11 10.3 16 15.1

35+ 37 1 3.3 2 6.7 3 10.0 1 3.3

Years since diagnosis 5-9 32 . . . . . . 1 9.1

10-14 219 4 2.4 5 3.0 6 3.6 15 9.0

15-19 326 28 11.8 20 8.4 20 8.4 36 15.1

20+ 217 9 5.9 8 5.2 12 7.8 20 13.2

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

14 Psychological Health-Brief Symptom Inventory-18: Medulloblastoma/PNET

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 14 . . . . 1 9.1 1 9.1

Years since diagnosis 5-9 11 . . . . . . . .

10-14 91 1 1.3 . . 3 3.9 5 6.6

15-19 121 7 7.7 4 4.4 8 8.6 11 12.0

20+ 86 5 7.6 3 4.5 7 10.6 9 13.6

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

15 Psychological Health-Brief Symptom Inventory-18: Hodgkin

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 3046 227 8.3 186 6.8 264 9.7 261 9.6

Age at baseline 18-19 62 4 10.3 4 10.3 2 5.1 7 17.9

20-24 376 20 6.6 11 3.7 18 6.0 26 8.6

25-29 798 57 8.2 54 7.8 61 8.8 74 10.6

30-34 949 72 8.2 57 6.5 99 11.3 84 9.6

35+ 861 74 9.0 60 7.3 84 10.3 70 8.6

Years since diagnosis 5-9 206 9 8.2 8 7.3 13 11.8 12 10.9

10-14 922 54 6.6 44 5.3 58 7.0 83 10.1

15-19 1010 71 7.6 63 6.7 92 9.8 76 8.1

20+ 908 93 10.8 71 8.3 101 11.7 90 10.5

Age at diagnosis 1-4 68 8 13.8 6 10.3 8 13.8 7 12.1

5-9 381 33 9.7 23 6.7 29 8.5 35 10.3

10-14 1113 88 8.7 73 7.2 100 9.9 107 10.5

15-20 1484 98 7.4 84 6.4 127 9.7 112 8.5

Treatment Surgery only 2 1 50.0 1 50.0 1 50.0 1 50.0

Chemotherapy, no radiation 357 28 8.5 21 6.4 26 7.9 28 8.5

Radiation, no chemotherapy 641 39 6.5 36 6.0 51 8.4 52 8.6

Chemotherapy and radiation 1720 137 9.0 108 7.1 162 10.7 159 10.5

Unknown 326 22 8.0 20 7.3 24 8.7 21 7.6

Males All cases 1585 118 8.6 99 7.2 110 8.0 143 10.4

Age at baseline 18-19 49 4 12.1 4 12.1 2 6.1 6 18.2

20-24 239 17 9.1 9 4.8 11 5.9 23 12.3

25-29 445 32 8.5 29 7.7 27 7.2 42 11.1

30-34 480 35 8.1 27 6.3 40 9.3 42 9.8

35+ 372 30 8.7 30 8.7 30 8.7 30 8.7

Years since diagnosis 5-9 111 7 13.0 6 11.1 4 7.4 8 14.8

10-14 473 34 8.4 22 5.4 24 5.9 52 12.8

15-19 539 31 6.4 33 6.8 34 7.0 37 7.7

20+ 462 46 10.7 38 8.9 48 11.2 46 10.7

Age at diagnosis 1-4 49 6 15.4 5 12.8 6 15.4 5 12.8

5-9 276 24 9.9 17 7.0 23 9.4 24 9.9

10-14 576 42 8.2 37 7.2 38 7.4 57 11.1

15-20 684 46 8.0 40 7.0 43 7.5 57 9.9

Treatment Surgery only 1 . . . . . . . .

Chemotherapy, no radiation 182 16 9.9 12 7.5 11 6.8 18 11.2

Radiation, no chemotherapy 328 23 7.5 19 6.2 26 8.4 31 10.1

Chemotherapy and radiation 881 68 9.1 56 7.5 59 7.9 82 11.0

Unknown 193 11 7.0 12 7.6 14 8.9 12 7.6

Females All cases 1461 109 8.0 87 6.4 154 11.3 118 8.7

Age at baseline 18-19 13 . . . . . . 1 16.7

20-24 137 3 2.6 2 1.8 7 6.1 3 2.6

25-29 353 25 7.9 25 7.9 34 10.7 32 10.1

30-34 469 37 8.3 30 6.7 59 13.2 42 9.4

35+ 489 44 9.3 30 6.3 54 11.4 40 8.4

Years since diagnosis 5-9 95 2 3.6 2 3.6 9 16.1 4 7.1

CCSS data from Jan2020 data freeze Based on items in J.16-J.35/K.1-K.18 Presented only for those age 18 and over at baseline, since questions are very different for those under 18. 1 Global Severity Index indicates adverse outcome (T-score>=63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

16 Psychological Health-Brief Symptom Inventory-18: Hodgkin

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

10-14 449 20 4.8 22 5.3 34 8.1 31 7.4

15-19 471 40 8.8 30 6.6 58 12.8 39 8.6

20+ 446 47 10.9 33 7.7 53 12.3 44 10.2

Age at diagnosis 1-4 19 2 10.5 1 5.3 2 10.5 2 10.5

5-9 105 9 9.2 6 6.1 6 6.1 11 11.2

10-14 537 46 9.2 36 7.2 62 12.4 50 10.0

15-20 800 52 7.0 44 5.9 84 11.3 55 7.4

Treatment Surgery only 1 1 . 1 . 1 . 1 .

Chemotherapy, no radiation 175 12 7.1 9 5.3 15 8.9 10 5.9

Radiation, no chemotherapy 313 16 5.4 17 5.7 25 8.4 21 7.1

Chemotherapy and radiation 839 69 8.9 52 6.7 103 13.3 77 9.9

Unknown 133 11 9.3 8 6.8 10 8.5 9 7.6

CCSS data from Jan2020 data freeze Based on items in J.16-J.35/K.1-K.18 Presented only for those age 18 and over at baseline, since questions are very different for those under 18. 1 Global Severity Index indicates adverse outcome (T-score>=63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

17 Psychological Health-Brief Symptom Inventory-18: NHL

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 1902 144 8.4 121 7.0 147 8.5 195 11.3

Age at baseline 18-19 132 5 5.6 6 6.7 5 5.6 11 12.4

20-24 469 32 7.7 20 4.8 33 8.0 51 12.3

25-29 569 52 10.1 43 8.3 56 10.8 58 11.2

30-34 483 38 8.2 36 7.7 33 7.1 52 11.2

35+ 249 17 7.1 16 6.6 20 8.3 23 9.5

Years since diagnosis 5-9 74 2 5.0 3 7.5 3 7.5 4 10.0

10-14 543 42 8.6 37 7.6 42 8.6 65 13.4

15-19 717 59 8.9 46 7.0 57 8.6 66 10.0

20+ 568 41 7.6 35 6.5 45 8.4 60 11.2

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

18 Psychological Health-Brief Symptom Inventory-18: NHL

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 84 9 11.3 6 7.5 10 12.5 9 11.3

Years since diagnosis 5-9 18 . . . . 1 12.5 . .

10-14 175 18 11.1 11 6.8 24 14.8 20 12.3

15-19 241 17 7.5 14 6.1 19 8.3 18 7.9

20+ 178 13 7.7 11 6.5 18 10.7 14 8.3

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

19 Psychological Health-Brief Symptom Inventory-18: Wilms

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 1441 79 6.2 68 5.3 96 7.5 92 7.2

Age at baseline 18-19 306 12 5.7 14 6.6 16 7.6 16 7.6

20-24 669 41 6.6 31 5.0 44 7.1 50 8.1

25-29 374 22 6.3 18 5.1 29 8.3 20 5.7

30-34 74 3 4.1 4 5.4 5 6.8 5 6.8

35+ 18 1 5.9 1 5.9 2 11.8 1 5.9

Years since diagnosis 5-9 11 2 40.0 2 40.0 1 20.0 . .

10-14 170 9 7.5 8 6.7 9 7.5 9 7.5

15-19 662 37 6.4 30 5.2 46 7.9 45 7.7

20+ 598 31 5.5 28 4.9 40 7.1 38 6.7

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

20 Psychological Health-Brief Symptom Inventory-18: Wilms

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Years since diagnosis 5-9 7 1 25.0 1 25.0 . . . .

10-14 111 5 5.8 5 5.8 6 7.0 5 5.8

15-19 380 18 5.2 16 4.6 33 9.5 21 6.1

20+ 327 22 7.0 18 5.7 32 10.2 21 6.7

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

21 Psychological Health-Brief Symptom Inventory-18: Neuroblastoma

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 991 60 7.1 53 6.3 64 7.6 79 9.4

Age at baseline 18-19 237 15 9.6 13 8.3 11 7.1 16 10.3

20-24 540 35 7.2 33 6.8 45 9.3 50 10.3

25-29 170 6 3.8 5 3.2 6 3.8 8 5.1

30-34 36 3 8.3 1 2.8 2 5.6 4 11.1

35+ 8 1 14.3 1 14.3 . . 1 14.3

Years since diagnosis 5-9 8 . . . . . . . .

10-14 54 4 10.5 4 10.5 7 18.4 4 10.5

15-19 391 23 7.7 18 6.0 23 7.7 24 8.0

20+ 538 33 6.6 31 6.2 34 6.8 51 10.1

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

22 Psychological Health-Brief Symptom Inventory-18: Neuroblastoma

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 5 1 20.0 1 20.0 . . 1 20.0

Years since diagnosis 5-9 6 . . . . . . . .

10-14 29 4 16.0 4 16.0 4 16.0 3 12.0

15-19 210 17 9.7 12 6.9 20 11.4 16 9.1

20+ 275 18 6.9 16 6.2 22 8.5 20 7.7

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

23 Psychological Health-Brief Symptom Inventory-18: STS

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 1415 104 8.2 78 6.2 111 8.8 127 10.0

Age at baseline 18-19 125 7 7.8 2 2.2 9 10.0 10 11.1

20-24 425 26 7.2 16 4.5 32 8.9 40 11.1

25-29 392 33 9.1 30 8.3 29 8.0 35 9.7

30-34 297 23 8.2 17 6.1 30 10.6 25 8.9

35+ 176 15 8.7 13 7.6 11 6.4 17 9.9

Years since diagnosis 5-9 88 4 8.2 4 8.2 4 8.2 6 12.2

10-14 314 23 8.2 20 7.2 25 9.0 31 11.1

15-19 500 31 6.9 22 4.9 35 7.8 45 10.1

20+ 513 46 9.4 32 6.6 47 9.6 45 9.2

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

24 Psychological Health-Brief Symptom Inventory-18: STS

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 92 11 12.4 9 10.1 9 10.1 11 12.4

Years since diagnosis 5-9 48 2 7.1 2 7.1 2 7.1 2 7.1

10-14 144 13 9.9 11 8.4 13 9.9 13 9.9

15-19 233 17 7.9 9 4.2 20 9.3 23 10.7

20+ 233 26 11.6 18 8.0 25 11.1 22 9.8

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

25 Psychological Health-Brief Symptom Inventory-18: All bone

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 2002 156 8.9 134 7.6 172 9.8 202 11.5

Age at baseline 18-19 72 2 5.1 2 5.1 5 12.8 1 2.6

20-24 388 28 9.6 17 5.8 25 8.6 44 15.1

25-29 568 41 8.2 38 7.6 51 10.2 53 10.6

30-34 566 47 8.8 41 7.7 48 9.0 62 11.7

35+ 408 38 9.6 36 9.1 43 10.9 42 10.7

Years since diagnosis 5-9 185 7 8.8 5 6.3 12 15.0 10 12.5

10-14 645 50 8.8 43 7.5 49 8.6 67 11.7

15-19 672 58 9.3 49 7.8 59 9.4 71 11.3

20+ 500 41 8.6 37 7.7 52 10.9 54 11.3

Age at diagnosis =63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

26 Psychological Health-Brief Symptom Inventory-18: All bone

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

35+ 183 21 11.7 20 11.2 25 14.0 22 12.3

Years since diagnosis 5-9 86 3 7.7 2 5.1 6 15.4 4 10.3

10-14 308 32 11.1 20 6.9 31 10.7 34 11.8

15-19 328 29 9.4 27 8.7 36 11.6 29 9.4

20+ 244 25 10.5 22 9.2 30 12.6 27 11.3

Age at diagnosis =63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

27 Psychological Health-Brief Symptom Inventory-18: Ewings

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 677 49 8.6 44 7.7 50 8.7 62 10.8

Age at baseline 18-19 36 2 13.3 2 13.3 3 20.0 . .

20-24 170 9 7.1 7 5.6 9 7.1 17 13.5

25-29 204 14 8.0 11 6.3 16 9.1 16 9.1

30-34 164 13 8.4 13 8.4 13 8.4 17 11.0

35+ 103 11 10.8 11 10.8 9 8.8 12 11.8

Years since diagnosis 5-9 71 1 5.0 1 5.0 2 10.0 1 5.0

10-14 222 15 8.0 13 7.0 14 7.5 20 10.7

15-19 219 20 9.7 16 7.8 16 7.8 24 11.7

20+ 165 13 8.2 14 8.8 18 11.3 17 10.7

Age at diagnosis 1-4 33 4 16.0 3 12.0 2 8.0 5 20.0

5-9 156 8 5.7 7 5.0 14 9.9 13 9.2

10-14 271 19 8.3 17 7.5 19 8.3 25 11.0

15-20 217 18 10.1 17 9.6 15 8.4 19 10.7

Treatment Surgery only 1 . . . . . . . .

Chemotherapy, no radiation 191 13 7.3 15 8.4 13 7.3 20 11.2

Radiation, no chemotherapy 2 . . . . . . . .

Chemotherapy and radiation 426 32 9.1 25 7.1 32 9.1 37 10.6

Unknown 57 4 9.8 4 9.8 5 12.2 5 12.2

Males All cases 358 21 7.2 19 6.5 20 6.9 35 12.0

Age at baseline 18-19 20 . . . . 2 40.0 . .

20-24 87 2 3.1 1 1.6 3 4.7 8 12.5

25-29 105 7 8.2 7 8.2 6 7.1 9 10.6

30-34 90 8 9.9 8 9.9 7 8.6 12 14.8

35+ 56 4 7.1 3 5.4 2 3.6 6 10.7

Years since diagnosis 5-9 41 . . . . 1 6.7 1 6.7

10-14 111 3 3.6 6 7.1 5 6.0 9 10.7

15-19 119 12 11.1 8 7.4 5 4.6 15 13.9

20+ 87 6 7.1 5 6.0 9 10.7 10 11.9

Age at diagnosis 1-4 20 2 14.3 1 7.1 2 14.3 2 14.3

5-9 79 3 4.4 1 1.5 5 7.4 9 13.2

10-14 143 9 7.6 9 7.6 9 7.6 15 12.6

15-20 116 7 7.8 8 8.9 4 4.4 9 10.0

Treatment Chemotherapy, no radiation 101 6 6.4 6 6.4 7 7.4 13 13.8

Radiation, no chemotherapy 1 . . . . . . . .

Chemotherapy and radiation 222 14 8.1 11 6.4 12 7.0 20 11.6

Unknown 34 1 4.2 2 8.3 1 4.2 2 8.3

Females All cases 319 28 10.0 25 8.9 30 10.7 27 9.6

Age at baseline 18-19 16 2 20.0 2 20.0 1 10.0 . .

20-24 83 7 11.3 6 9.7 6 9.7 9 14.5

25-29 99 7 7.8 4 4.4 10 11.1 7 7.8

30-34 74 5 6.8 5 6.8 6 8.2 5 6.8

35+ 47 7 15.2 8 17.4 7 15.2 6 13.0

Years since diagnosis 5-9 30 1 20.0 1 20.0 1 20.0 . .

10-14 111 12 11.7 7 6.8 9 8.7 11 10.7

CCSS data from Jan2020 data freeze Based on items in J.16-J.35/K.1-K.18 Presented only for those age 18 and over at baseline, since questions are very different for those under 18. 1 Global Severity Index indicates adverse outcome (T-score>=63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

28 Psychological Health-Brief Symptom Inventory-18: Ewings

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

15-19 100 8 8.2 8 8.2 11 11.2 9 9.2

20+ 78 7 9.3 9 12.0 9 12.0 7 9.3

Age at diagnosis 1-4 13 2 18.2 2 18.2 . . 3 27.3

5-9 77 5 6.8 6 8.2 9 12.3 4 5.5

10-14 128 10 9.2 8 7.3 10 9.2 10 9.2

15-20 101 11 12.5 9 10.2 11 12.5 10 11.4

Treatment Surgery only 1 . . . . . . . .

Chemotherapy, no radiation 90 7 8.2 9 10.6 6 7.1 7 8.2

Radiation, no chemotherapy 1 . . . . . . . .

Chemotherapy and radiation 204 18 10.1 14 7.9 20 11.2 17 9.6

Unknown 23 3 17.6 2 11.8 4 23.5 3 17.6

CCSS data from Jan2020 data freeze Based on items in J.16-J.35/K.1-K.18 Presented only for those age 18 and over at baseline, since questions are very different for those under 18. 1 Global Severity Index indicates adverse outcome (T-score>=63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

29 Psychological Health-Brief Symptom Inventory-18: Osteosarcoma

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

Both sexes All cases 1228 103 9.4 87 7.9 115 10.5 133 12.1

Age at baseline 18-19 30 . . . . 2 9.5 . .

20-24 198 19 12.9 10 6.8 15 10.2 26 17.7

25-29 344 27 8.8 27 8.7 34 11.0 36 11.7

30-34 373 33 9.4 27 7.7 33 9.4 44 12.5

35+ 283 24 8.9 23 8.5 31 11.5 27 10.0

Years since diagnosis 5-9 109 6 10.5 4 7.0 10 17.5 8 14.0

10-14 390 34 9.6 29 8.2 33 9.3 46 13.0

15-19 422 38 9.6 33 8.4 41 10.4 45 11.4

20+ 307 25 8.5 21 7.2 31 10.6 34 11.6

Age at diagnosis 1-4 19 2 11.1 2 11.1 1 5.6 4 22.2

5-9 151 12 8.5 7 4.9 16 11.3 15 10.6

10-14 527 49 10.4 36 7.6 52 11.0 65 13.8

15-20 531 40 8.5 42 9.0 46 9.8 49 10.5

Treatment Surgery only 86 6 7.2 4 4.8 8 9.6 7 8.4

Chemotherapy, no radiation 935 78 9.2 69 8.2 87 10.3 102 12.1

Radiation, no chemotherapy 10 1 11.1 2 22.2 . . 1 11.1

Chemotherapy and radiation 79 8 12.5 5 7.8 11 17.2 9 14.1

Unknown 118 10 10.3 7 7.2 9 9.3 14 14.4

Males All cases 627 43 7.9 42 7.7 46 8.4 69 12.6

Age at baseline 18-19 12 . . . . . . . .

20-24 95 5 7.7 5 7.7 5 7.7 9 13.8

25-29 183 12 7.6 13 8.3 13 8.3 22 14.0

30-34 178 15 8.9 12 7.1 14 8.3 26 15.5

35+ 159 11 7.4 12 8.1 14 9.4 12 8.1

Years since diagnosis 5-9 55 4 16.0 3 12.0 5 20.0 5 20.0

10-14 208 14 7.7 16 8.7 12 6.6 23 12.6

15-19 210 17 8.7 14 7.1 18 9.2 26 13.3

20+ 154 8 5.6 9 6.3 11 7.7 15 10.5

Age at diagnosis 1-4 12 . . . . . . 1 8.3

5-9 72 3 4.5 4 6.0 6 9.0 6 9.0

10-14 239 17 8.3 12 5.8 17 8.3 29 14.1

15-20 304 23 8.8 26 9.9 23 8.8 33 12.6

Treatment Surgery only 30 2 6.9 1 3.4 3 10.3 4 13.8

Chemotherapy, no radiation 475 28 6.7 30 7.1 31 7.4 50 11.9

Radiation, no chemotherapy 6 . . 1 20.0 . . 1 20.0

Chemotherapy and radiation 40 5 15.2 4 12.1 6 18.2 5 15.2

Unknown 76 8 13.3 6 10.0 6 10.0 9 15.0

Females All cases 601 60 10.9 45 8.2 69 12.5 64 11.6

Age at baseline 18-19 18 . . . . 2 15.4 . .

20-24 103 14 17.1 5 6.1 10 12.2 17 20.7

25-29 161 15 9.9 14 9.2 21 13.8 14 9.3

30-34 195 18 9.8 15 8.2 19 10.3 18 9.8

35+ 124 13 10.7 11 9.1 17 14.0 15 12.4

Years since diagnosis 5-9 54 2 6.3 1 3.1 5 15.6 3 9.4

CCSS data from Jan2020 data freeze Based on items in J.16-J.35/K.1-K.18 Presented only for those age 18 and over at baseline, since questions are very different for those under 18. 1 Global Severity Index indicates adverse outcome (T-score>=63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

30 Psychological Health-Brief Symptom Inventory-18: Osteosarcoma

Global Severity Index 1 Anxiety 2

Somatic Distress 2 Depression 2

All cases N % N % N % N %

10-14 182 20 11.7 13 7.6 21 12.3 23 13.5

15-19 212 21 10.6 19 9.5 23 11.6 19 9.6

20+ 153 17 11.3 12 8.0 20 13.3 19 12.7

Age at diagnosis 1-4 7 2 33.3 2 33.3 1 16.7 3 50.0

5-9 79 9 12.0 3 4.0 10 13.3 9 12.0

10-14 288 32 12.1 24 9.1 35 13.2 36 13.6

15-20 227 17 8.3 16 7.8 23 11.2 16 7.8

Treatment Surgery only 56 4 7.4 3 5.6 5 9.3 3 5.6

Chemotherapy, no radiation 460 50 11.8 39 9.2 56 13.1 52 12.2

Radiation, no chemotherapy 4 1 25.0 1 25.0 . . . .

Chemotherapy and radiation 39 3 9.7 1 3.2 5 16.1 4 12.9

Unknown 42 2 5.4 1 2.7 3 8.1 5 13.5

CCSS data from Jan2020 data freeze Based on items in J.16-J.35/K.1-K.18 Presented only for those age 18 and over at baseline, since questions are very different for those under 18. 1 Global Severity Index indicates adverse outcome (T-score>=63) on the BSI-18 2 Anxiety, Somatic Distress and Depression are based on adverse outcome (T-score>=63) on BSI subscale n=7 participants with no baseline information are not included

https://J.16-J.35/K.1-K.18

Psychological Health-Brief Symptom Inventory-18All cancers Table 1

All leukemias Table 1

ALL Table 1

AML Table 1

All CNS Table 1

Astrocytomas Table 1

Medulloblastoma/PNETTable 1

Hodgkin Table 1

NHL Table 1

Wilms Table 1

Neuroblastoma Table 1

STS Table 1

All bone Table 1

Ewings Table 1

Osteosarcoma Table 1