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The Effect of Carvacrol on MuscarinicReceptors of Guinea-pig Tracheal Chainsptr_3290 530..535

M. H. Boskabady,1* Z. Jafari2 and I. Pouraboli2

1Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences,Mashhad, Iran2Department of Biology, Bahonar University, Kerman, Iran

The effects of three concentrations of carvacrol, the constituent ofZataria multiflora Boiss (a monoterpenoid

phenol, C10H14O) and 10 nM atropine on muscarinic receptors were tested on: non-incubated (n = 7), incubatedtracheal chains with propranolol and chlorpheniramine (n= 6) and incubated with propranolol (n= 5).The EC50of all three concentrations of carvacrol in incubated tissues with propranolol and chlorpheniramine was signifi-

cantly greater than those of incubated tissues with propranolol and non-incubated trachea (p < 0.05 top < 0.001).

The EC50 of two higher concentrations of carvacrol (0.2 and 0.4 mg/mL) in incubated tissues with propranolol

was also significantly greater than those of non-incubated trachea (p