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Publication list - SMILE - peer reviewed papers 05| 2016 ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore recommend that you carefully assess suitability for everyday use in your practice. Page 1 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt Y M Journal Author Title Keywords 2016 June Journal of Ophthalmology Alex L. K. Ng, Tommy C. Y. Chan, George P. M. Cheng, Vishal Jhanji, Cong Ye, Victor C. P. Woo, and Jimmy S. M. Lai Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia SMILE, crosslinking, SMILE Xtra, SMILE Extra 2016 May Int J Ophthalmol. Ma J, Cao NJ, Xia LK. Efficacy, safety, predictability, aberrations and corneal biomechnical parameters after SMILE and FLEx: Meta-analysis. Higher-order aberrations, FLEx, SMILE, comparison 2016 May JCRS Park JH, Lee JH, Koo HJ. Small-incision lenticule extraction in posterior polymorphic corneal dystrophy. Corneal dystrophy, SMILE

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Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 1 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 June Journal of Ophthalmology

Alex L. K. Ng, Tommy C. Y. Chan, George P. M. Cheng, Vishal Jhanji, Cong Ye, Victor C. P. Woo, and Jimmy S. M. Lai

Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia

SMILE, crosslinking, SMILE Xtra, SMILE Extra

2016 May Int J Ophthalmol. Ma J, Cao NJ, Xia LK. Efficacy, safety, predictability, aberrations and corneal biomechnical parameters after SMILE and FLEx: Meta-analysis.

Higher-order aberrations, FLEx, SMILE, comparison

2016 May JCRS Park JH, Lee JH, Koo HJ. Small-incision lenticule extraction in posterior polymorphic corneal dystrophy.

Corneal dystrophy, SMILE

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 2 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 May J Refract Surg. Liu YC, Teo EP, Lwin NC, Yam GH, Mehta JS.

Early Corneal Wound Healing and Inflammatory Responses After SMILE: Comparison of the Effects of Different Refractive Corrections and Surgical Experiences.

Rabbit model, wound healing, inflammation, early inflammatory, keratocyte response, high myopia, low myopia

2016 May Asia Pac J Ophthalmol (Phila).

Pillar A, Krueger R. Advances in Refractive Surgery: June 2014 to July 2015. Literature review 2014 – 2015

2016 May Sci Rep Yam GH, Yusoff NZ, Goh TW, Setiawan M, Lee XW, Liu YC, Mehta JS

Decellularization of human stromal refractive lenticules for corneal tissue engineering.

Allogeneic implantation

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 3 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Apr Int J Ophthalmol Qiu P Yang YB

Early changes to dry eye and ocular surface after small-incision lenticule extraction for myopia.

Subjective dry eye symptoms, tear film breakup time, Schirmer test, tear meniscus height, corneal fluorescein staining

2016 Apr Int J Ophthalmol.

Wang D Liu M Chen Y Zhang X Xu Y Wang J To C Wang J Liu Q

Short term effects of small incision lenticule extraction surgery on corneal endothelium.

Corneal endothelium, retrospective study

2016 Apr JRS Yu, M; Chen M; Wang B; Zou L; Zhu X; Dai J

LETTER: Comparison of Visual Aberrations After SMILE and LASEK for Myopia.

Letter, visual quality, aberrations, spherical aberrations

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 4 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Apr JRS

Zhang Y, Shen Q, Jia Y, Zhou D, Zhou J

Clinical Outcomes of SMILE and FS-LASIK Used to Treat Myopia: A Meta-analysis.

Systematic review, meta-analysis, clinical outcomes, safety, efficacy, dry eye

2016 Apr Curr Eye Res.

Shetty R Shroff R Kaweri L Jayadev C Kummelil M Sinha Roy A

Intra-Operative Cap Repositioning in Small Incision Lenticule Extraction (SMILE) for Enhanced Visual Recovery.

Bowman´s membrane, microdistorsions, optical quality, visual recovery

2016 Apr Cornea Zhang, J Wang, Y Chen, X

Comparison of Moderate- to High-Astigmatism Corrections Using WaveFront-Guided Laser In Situ Keratomileusis and Small-Incision Lenticule Extraction.

Astigmatism correction, high astigmatism, moderate astigmatism, targed-induced astigmatism, undercorrection

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 5 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Mar PLoS One

Zhang, C Ding, H He, M Liu, L Liu, L Li, G Niu, B Zhong, X

Comparison of Early Changes in Ocular Surface and Inflammatory Mediators between Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction.

Corneal sensitivity, Schirmer test, noninvasive tear breakup time, tear meniscus height, corneal fluorescein, staining, OSDI, nerve growth factor

2016 Mar Cornea

Luft N Ring M Dirisamer M Mursch-Edlmayr A Pretzl J Bolz M Priglinger S

Semiautomated SD-OCT Measurements of Corneal Sublayer Thickness in Normal and Post-SMILE Eyes.

Corneal epithelial thickness, stromal thickness

2016 Mar Eye Contact Lens Wu W Wang Y

Corneal Higher-Order Aberrations of the Anterior Surface, Posterior Surface, and Total Cornea After SMILE, FS-LASIK, and FLEx Surgeries.

Higher-order aberration, posterior surface, total cornea, FLEx, SMILE, spherical aberrations

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 6 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Feb Curr Eye Res

Xia L Zhang J Wu J Yu K

Comparison of Corneal Biological Healing After Femtosecond LASIK and Small Incision Lenticule Extraction Procedure.

Dry eye, biomechanical status, visual acuity, manifest refraction, tear break-up time, Schirmer test, corneal sensitivity, visual outcomes

2016 Feb JCRS

Osman I Awad R Shi W Shousha M

Suction loss during femtosecond laser–assisted small-incision lenticule extraction: Incidence and analysis of risk factors.

Suction loss, learning curve, surgical experience, cap diameter

2016 Feb Cont Lens Anterior Eye

Wang B Zhang Z Naidu R Chu R Dai J Qu X Yu Z Zhou H

Comparison of the change in posterior corneal elevation and corneal biomechanical parameters after small incision lenticule extraction and femtosecond laser-assisted LASIK for high myopia correction.

Corneal elevation changes, biomechanical changes, ORA, LASIK, SMILE

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 7 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Feb Graefes Arch Clin Exp Ophthalmol

Hansen R Lyhne N Grauslund J Vestergaard A

Small-incision lenticule extraction (SMILE): outcomes of 722 eyes treated for myopia and myopic astigmatism.

Predictability, efficiency, safety, myopia, myopic astigmatism

2016 Feb Plos One

Zhao, Y Li, M Zhao, J Knorz, M Sun, L Tian, M Zhou, M

Posterior Corneal Elevation after Small Incision Lenticule Extraction for Moderate and High Myopia.

Corneal elevation, moderate myopia, high myopia

2016 Feb Lasers Med Sci Sekundo, W Reinstein, D Blum, M

Improved lenticule shape for hyperopic femtosecond lenticule extraction (ReLEx® FLEx): a pilot study.

Hyperopia, FLEx

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 8 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Feb JCRS

Pradhan K Reinstein D Carp G Archer T Gobbe M Dhungana P

Quality control outcomes analysis of small-incision lenticule extraction for myopia by a novice surgeon at the first refractive surgery unit in Nepal during the first 2 years of operation

Outcome analysis, low to high myopia

2016 Feb Expert Review of Ophthalmology

Piñero-Llorens D Murueta-Goyena Larrañaga A Hanneken L

Visual outcomes and complications of smallincision lenticule extraction: a review.

2016 Feb Cornea Liu M, Chen Y, Wang D, Zhou Y, Zhang X, He J, Zhang T, Sun Y, Liu Q.

Clinical Outcomes After SMILE and Femtosecond Laser-Assisted LASIK for Myopia and Myopic Astigmatism: A Prospective Randomized Comparative Study.

Clinical outcomes, comparison SMILE LASIK, comparative study, spherical aberrations, UDVA, visual recovery

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 9 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2016 Jan BJO

Blum M Täubig K Gruhn C Sekundo W Kunert K

Five-year results of Small Incision Lenticule Extraction (ReLEx SMILE).

Long term results

2015 Jan Cornea Bhandari V, Ganesh S, Brar S, Pandey R.

Application of the SMILE-Derived Glued Lenticule Patch Graft in Microperforations and Partial-Thickness Corneal Defects.

Microperforations, glued lentiucle patch graft, corneal defects, fibrin glue, corneal tears

2015 Dec JRS Praneetha Thulasi, MD; Sang Woo Kim, MD; Rohit Shetty, FRCS, PhD; J. Bradley Randleman, MD

Recalcitrant Epithelial Ingrowth After SMILE Treated With a Hydrogel Ocular Sealant

Interface epithelial ingrowth

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 10 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Dec Der Ophthalmologe Kohnen T., Remy M.

Complications of corneal lamellar refractive surgery Komplikationen der lamellären refraktiven Hornhautchirurgie

Complications

2015 Dec JRS

Manrong Yu, MM; Minjie Chen, PhD; Bingjie Wang, MM; Leilei Zou, MD; Xiaoyu Zhu, MD; Jinhui Dai, PhD

Comparison of Visual Quality After SMILE and LASEK for Mild to Moderate Myopia

Mild to moderate Myopia, visual acuity, corneal topography, contrast sensitivity, wavefront aberrations, higher order aberrations, patient satisfaction

2015 Nov JCRS Sachdev G, Sachdev MS, Sachdev R, Gupta H.

Unilateral corneal ectasia following small-incision lenticule extraction.

Corneal ectasia, unilateral

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 11 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Nov JRS

Xu L Wang Y Li J Liu Y Wu W Zhang H Wu Y Khan G

Comparison of Forward Light Scatter Changes Between SMILE, Femtosecond Laser-assisted LASIK, and Epipolis LASIK: Results of a 1-Year Prospective Study.

Light scatter changes, straylight

2015 Nov JRS

Miao H Tian M Xu Y Chen Y Zhou X

Visual Outcomes and Optical Quality After Femtosecond Laser Small Incision Lenticule Extraction: An 18-Month Prospective Study.

Long-term visual outcomes, optical quality, patient satisfaction, aberrations, intraocular scattering, retinal image quality, spherical aberrations, coma, trefoil

2015 Nov JRS

Zhao Y Li M Sun L Zhao J Chen Y Zhou X

Lenticule Quality After Continuous Curvilinear Lenticulerrhexis in SMILE Evaluated With Scanning Electron Microscopy.

Survace characteristics, lenticule quality, CCL-technique, continuous curvilinear lenticulerrhexis

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 12 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Nov JCRS

Enrique O. Graue-Hernandez; Gabriela L. Pagano, Guillermo Garcia-De la Rosa Arturo Ramirez-Miranda, Jesus Cabral-Macias, Alejandro Lichtinger, Alexandra Abdala-Figuerola, Alejandro Navas

Combined small-incision lenticule extraction and intrastromal corneal collagen crosslinking to treat mild keratoconus: Long-term follow-up

Visual, refractive and topographic outcomes SMILE crosslinking, mild keratoconus, forme fruste keratoconus, irregular corneas

2015 Nov JCRS

Yishan Qian Jia Huang Xingtao Zhou Yutung Wang, BS

Comparison of femtosecond laser small-incision lenticule extraction and laser-assisted subepithelial keratectomy to correct myopic astigmatism

Efficacy, retrospective cross-sectional study, LASEK, SMILE, astigmatism, nomogram

2015 Nov Curr Eye Res. Sefat SM, Wiltfang R, Bechmann M, Mayer WJ, Kampik A, Kook D.

Evaluation of Changes in Human Corneas After Femtosecond Laser-Assisted LASIK and Small-Incision Lenticule Extraction (SMILE) Using Non-Contact Tonometry and Ultra-High-Speed Camera (Corvis ST).

Biomechanic, LASIK, SMILE, moderate to high myopia, astigmatism, Corvis

2015 Nov BMJ Kamiya K, Shimizu K, Igarashi A, Kobashi H.

Visual and refractive outcomes of small incision lenticule extraction for the correction of myopia: 1-year follow-up.

1-year-follow-up, safety, predictability, efficacy, stability, corneal endothelial cell loss, adverse events

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 13 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Oct JCRS Ang M, Ho H, Fenwick E, Lamoureux E, Htoon HM, Koh J, Tan D, Mehta JS.

Vision-related quality of life and visual outcomes after small-incision lenticule extraction and laser in situ keratomileusis.

Vision-related quality of life score, SMILE, LASIK, Wavelight Allegretto, VisuMax

2015 Oct BMC Ophthalmol. He M, Huang W, Zhong X. Central corneal sensitivity after small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a meta-analysis of comparative studies.

Corneal sensitivity, comparison

2015 Oct J Refract Surg. Pedersen IB, Ivarsen A, Hjortdal J. Three-Year Results of Small Incision Lenticule Extraction for High Myopia: Refractive Outcomes and Aberrations

Long term results, long-term results, high myopia, 3-year-results, 3-year-follow up

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 14 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Oct Cornea Ganesh, Sri MS, DNB; Brar, Sheetal MS

Femtosecond Intrastromal Lenticular Implantation Combined With Accelerated Collagen Cross-Linking for the Treatment of Keratoconus—Initial Clinical Result in 6 Eyes

Lenticule implantation, cross linking, cross-linking, keratoconus, Fili

2015 Oct J Refract Surg. Donate D, Thaëron R. Preliminary Evidence of Successful Enhancement After a Primary SMILE Procedure With the Sub-Cap-Lenticule-Extraction Technique.

Retreatment, touch up,

2015 Oct Cornea El-Massry AA, Goweida MB, Shama Ael-S, Elkhawaga MH, Abdalla MF.

Contralateral Eye Comparison Between Femtosecond Small Incision Intrastromal Lenticule Extraction at Depths of 100 and 160 μm.

HOA, higher-order aberrations, biomechanics, cap thickness

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 15 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Oct Journal of Ophthalmology

Wenjing Wu, Yan Wang

The Correlation Analysis between Corneal Biomechanical Properties and the Surgically Induced Corneal High-Order Aberrations after Small Incision Lenticule Extraction and Femtosecond Laser In Situ Keratomileusis

Corneal biomechanics, induced HOAs higher order aberrations, higher-order aberrations, CRF, corneal resistance factor

2015 Sep J Refract Surg. Güell JL, Verdaguer P, Mateu-Figueras G, Elies D, Gris O, El Husseiny MA, Manero F, Morral M.

SMILE Procedures With Four Different Cap Thicknesses for the Correction of Myopia and Myopic Astigmatism.

Cap thickness

2015 Sep J Refract Surg. Reinstein DZ, Gobbe M, Gobbe L, Archer TJ, Carp GI.

Optical Zone Centration Accuracy Using Corneal Fixation-based SMILE Compared to Eye Tracker-based Femtosecond Laser-assisted LASIK for Myopia.

Optical zone centration accuracy

2015 Sep J Refract Surg. Agca A, Cankaya KI, Yilmaz I, Yildirim Y, Yasa D, Olcucu O, Demircan A, Demirok A, Yilmaz OF.

Fellow Eye Comparison of Nerve Fiber Regeneration After SMILE and Femtosecond Laser-assisted LASIK: A Confocal Microscopy Study.

Nerve fiber regeneration

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 16 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Sep J Refract Surg. Mastropasqua L, Calienno R, Lanzini M, Nubile M.

Small Incision Lenticule Extraction After Deep Anterior Lamellar Keratoplasty.

SMILE after DALK, Keratoplasty

2015 Sep Appl Opt. Lou Q, Wang Y, Wang Z, Liu Y, Zhang L, Fang H.

Statistical characteristics of aberrations of human eyes after small incision lenticule extraction surgery and analysis of visual performance with individual eye model.

Wavefront abberations preoperative and postopverative

2015 Sep Cornea Kim BK, Mun SJ, Lee DG, Kim JR, Kim HS, Chung YT.

Full-Thickness Astigmatic Keratotomy Combined With Small-Incision Lenticule Extraction to Treat High-Level and Mixed Astigmatism.

Mixed astigmatism,

2015 Aug EyeVis Chansue E, Tanehsakdi M, Swasdibutra S, McAlinden C.

Efficacy, predictability and safety of small incision lenticule extraction (SMILE).

One-year-follow up, long term results

2015 Aug J Cataract Refract Surg

Reinstein DZ, Archer TJ, Gobbe M, Bartoli E.

Corneal sensitivity after small-incision lenticule extraction and laser in situ keratomileusis.

Corneal sensitivity

2015 July EyeVis Aristeidou A, Taniguchi EV, Tsatsos M, Muller R, McAlinden C, Pineda R, Paschalis EI.

The evolution of corneal and refractive surgery with the femtosecond laser.

Advances of femtosecond lasers to modern corneal and refractive surgery

2015 July Zhonghua Yan Ke Za Zhi.

Wu Z, Wang Y, Zhang L, Geng Weili, Jin Y, Zuo T.

[Wavefront analysis and comparison between small incision lenticule extraction and femtosecond laser in situ keratomilensis].

Changes in HOA, higher order aberrations, optical quality; article only in CHINESE

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 17 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Aug J Refract Surg. Qian Y, Huang J, Zhou X, Hanna RB Corneal Power Distribution and Functional Optical Zone Following Small Incision Lenticule Extraction for Myopia.

Corneal power distribution, ray tracing method, optical zone

2015 July/ Oct

Cornea Ramirez-Miranda A, Ramirez-Luquin T, Navas A, Graue-Hernandez EO

Refractive Lenticule Extraction Complications

Complications, complication management, FLEx, SMILE

2015 July Clin Ophthalmol. Ganesh S, Patel U, Brar S. Posterior corneal curvature changes following Refractive Small Incision Lenticule Extraction.

Posterior corneal curvature changes, corneal power, asphericity, low, moderate, high myopia

2015 July Cornea Dou R, Wang Y, Xu L, Wu D, Wu W, Li X.

Comparison of Corneal Biomechanical Characteristics After Surface Ablation Refractive Surgery and Novel Lamellar Refractive Surgery

Biomechanics, biomechanical changes, corneal hysteresis, corneal resistance factor

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 18 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 July Biomed Res Int. Liu YC, Jayasinghe L, Ang HP, Lwin NC, Yam GH, Mehta JS.

Effect of Intraoperative Corneal Stromal Pocket Irrigation in Small Incision Lenticule Extraction

Rabbit eyes, corneal pocket irrigation

2015 July J Cataract Refract Surg.

Remy M, Kohnen T. Corneal ectasia after femtosecond laser-assisted small-incision lenticule extraction in eyes with subclinical keratoconus/forme fruste keratoconus

Letter referring to: Mohamed Tarek El-Naggar “Bilateral ectasia after femtosecond laser–assisted small-incision lenticule extraction”

2015 July Zhonghua Yan Ke Za Zhi

Wei S, Wang Y, Zuo T, Lin J, Wang Y [The study of the changes of ultra- microstructure after a momentary action of femtosecond laser with human corneal tissue in vivo].

Article only in CHINESE

2015 July Curr Opin Ophthalmol.

Lee JK, Chuck RS, Park CY. Femtosecond laser refractive surgery: small-incision lenticule extraction vs. femtosecond laser-assisted LASIK.

Review article, comparison SMILE and FS LASIK, future of SMILE

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 19 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 July Br J Ophthalmol. Chan TC, Ng AL, Cheng GP, Wang Z, Ye C, Woo VC, Tham CC, Jhanji V.

Vector analysis of astigmatic correction after small-incision lenticule extraction and femtosecond-assisted LASIK for low to moderate myopic astigmatism

Low and moderate myopic astigmatism, LASIK SMILE comparison

2015 June J Cataract Refract Surg.

Mastropasqua L Bilateral ectasia after femtosecond laser-assisted small-incision lenticule extraction

Letter referring to: Mohamed Tarek El-Naggar “Bilateral ectasia after femtosecond laser–assisted small-incision lenticule extraction”

2015 June JOphthalmol. Ganesh S, Brar S. Clinical Outcomes of Small Incision Lenticule Extraction with Accelerated Cross-Linking (ReLEx SMILE Xtra) in Patients with Thin Corneas and Borderline Topography.

Cross-linking after SMILE, thin corneas, boarderline topography, higher refractive errors

2015 June Ophthalmic Physiol Opt.

Li X, Wang Y, Dou R. Aberration compensation between anterior and posterior corneal surfaces after Small incision lenticule extraction and Femtosecond laser-assisted laser in-situ keratomileusis

HOA, higher order aberrations, anterior corneal surfaces, posterior corneal surfaces, SMILE, LASIK

2015 June BMC Ophthalmol. Kim JR, Kim BK, Mun SJ, Chung YT, Kim HS

One-year outcomes of small-incision lenticule extraction (SMILE): mild to moderate myopia vs. high myopia.

High, moderate, mild myopia, efficacy, safety

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 20 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 June J Refract Surg. Sun L, Yao P, Li M, Shen Y, Zhao J, Zhou X.

The Safety and Predictability of Implanting Autologous Lenticule Obtained by SMILE for Hyperopia

Safety, effectiveness, stability, predictability, lenticule implantation, autologous lenticule, hyperopia, hyperopic corrections

2015 June Invest Ophthalmol Vis Sci.

Liu R, Zhao J, Xu Y, Li M, Niu L, Liu H2, Sun L, Chu R, Zhou X.

Femtosecond Laser-Assisted Corneal Small Incision Allogenic Intrastromal Lenticule Implantation in Monkeys: A Pilot Study.

Lenticule implantation, monkey study, allogenic intrastromal lenticule implantation, keratoectasia, presbyopia, hyperopia

2015 May Cornea Shetty R, Kaweri L, Pahuja N, Deshpande K, Thakkar M, Sinha Roy A.

Association Between Corneal Deformation and Ease of Lenticule Separation From Residual Stroma in Small Incision Lenticule Extraction.

Corneal deformation, lenticule separation,

2015 May J Cataract Refract Surg.

Qian Y, Huang J, Chu R, Zhao J, Li M, Zhou X, Olszewski E, Wang Y.

Influence of intraocular astigmatism on the correction of myopic astigmatism by femtosecond laser small-incision lenticule extraction.

Astigmatism, ORA

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 21 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 May J Cataract Refract Surg.

Wang Y, Cui C, Li Z, Tao X, Zhang C, Zhang X, Mu G.

Corneal ectasia 6.5 months after small-incision lenticule extraction. Ectasia, forme fruste keratoconus

2015 May J of Ophthalmlogy Kazutaka Kamiya, Kimiya Shimizu, Mayumi Yamagishi, Akihito Igarashi, and Hidenaga Kobashi

Anterior and Posterior Corneal Astigmatism after Refractive Lenticule Extraction for Myopic Astigmatism

Anterior posterior astigmatism

2015 May Ophthalmic Physiol Opt

Gyldenkerne A1, Ivarsen A, Hjortdal JØ.

Assessing the corneal power change after refractive surgery using Scheimpflug imaging.

Refractive change, manifest refraction, surgically induced refractive change

2015 May J Cataract Refract Surg

Sachdev MS, Gupta D, Sachdev G, Sachdev R.

Tailored stromal expansion with a refractive lenticule for crosslinking the ultrathin cornea.

Lenticule implantation, keratoconus

2015 Apr J Cataract Refract Surg

El-Naggar MT. Bilateral ectasia after femtosecond laser-assisted small-incision lenticule extraction.

Ectasia, subclinical keratoconus/forme fruste keratoconus

2015 Apr J Cataract Refract Surg

Sergienko, Nicolai M. Refractive Lenticule Extraction - Letter Mechanical lenticule cutting without flap

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 22 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Apr J Refract Surg. Gyldenkerne A, Ivarsen A, Hjortdal JØ.

Comparison of corneal shape changes and aberrations induced By FS-LASIK and SMILE for myopia

Corneal curvature, anterior corneal surface, posterior corneal surface, sagittal curvature, corneal power calculations, higher order aberrations

2015 Apr Cornea Dan Z Reinstein, MD, MA(Cantab), FRCSC, DABO, FRCOphth, FEBO

Small Incision Lenticule Extraction (SMILE) in 2015

Small incision lenticule extraction (SMILE), femtosecond laser, keyhole, flapless procedure

2015 Apr Cornea Liu M1, Sun Y, Wang D, Zhang T, Zhou Y, Zheng H, Liu Q.

Decentration of optical zone center and its impact on visual outcomes following SMILE.

Decentration, optical zone, corneal vertex

2015 Apr Cont Lens Anterior Eye

Zhang H, Wang Y, Xie S, Wu D, Wu W, Xu L.

Short-term and long-term effects of small incision lenticule extraction (SMILE) on corneal endothelial cells.

Corneal endothelium, endothelial cells

2015 Apr Br J Ophthalmol Kamiya K, Shimizu K, Igarashi A, H.

Effect of femtosecond laser setting on visual performance after small-incision lenticule extraction for myopia.

Settings, energy level, spot distance, optical quality, energy settings

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 23 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Apr PLoS One Kobashi H, Kamiya K, Ali MA, Igarashi A, Elewa ME, Shimizu K.

Comparison of astigmatic correction after femtosecond lenticule extraction and small-incision lenticule extraction for myopic astigmatism.

Astigmatism induction with or without flap, FLEx, SMILE

2015 Mar Cornea Wu F, Jin X, Xu Y, Yang Y.

Treatment of Corneal Perforation With Lenticules From Small Incision Lenticule Extraction Surgery: A Preliminary Study of 6 Patients.

Corneal perforation, therapeutical case, therapeutic, wound closure, lenticule usage, tissue, donor

2015 Mar J Cataract Refract Surg.

Tan DK, Tay WT, Chan C, Tan DT, Mehta JS.

Postoperative ocular higher-order aberrations and contrast sensitivity: Femtosecond lenticule extraction versus pseudo small-incision lenticule extraction.

Contrast sensitivity, HOAs, higher order aberrations, FLEx, PseudoSMILE, induction HOAs

2015 Mar Graefes Arch Clin Exp Ophthalmol.

Liu M1, Zhang T, Zhou Y, Sun Y, Wang D, Zheng H, Liu Q.

Corneal regeneration after femtosecond laser small-incision lenticule extraction: a prospective study.

Morphologic changes, epithelium, endothelium, keratocyte activity, fibrotic tissue, corneal wound-healing response, nerve regeneration

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 24 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Mar J Fr Ophtalmol Albou-Ganem C, Lavaud A, Amar R. SMILE: Refractive lenticule extraction for myopic correction

Moderate to high myopia, predictability, safety

2015 Mar/Apr

Asia-Pacific Journal of Ophthalmology

Naveen Mysore, MD, PhD and Ronald Krueger, MD, MSE

Advances in Refractive Surgery Progression in the field of refractive surgery May 2013 – June 2014

2015 Mar J Cataract Refract Surg.

Moshirfar M, McCaughey MV, Reinstein DZ, Shah R, Santiago-Caban L, Fenzl CR.

Small-incision lenticule extraction. Review article,

2015 Feb J Refract Surg Luo J, Yao P, Li M, Xu G, Zhao J, Tian M, Zhou X.

Quantitative analysis of Microdistortions in Bowman's Layer using optical coherence tomography after SMILE among different myopic corrections

Bowman´s membrane, Bowman´s layer, distortions, microdistorsions

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 25 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2015 Feb J Cataract Refract Surg.

Zhao J, He L, Yao P, Shen Y, Zhou Z, Miao H, Wang X, Zhou X.

Diffuse lamellar keratitis after small-incision lenticule extraction

Diffuse lamellar keratitis, potential complication

2015 Jan J Refract Surg.

Yu Zhao, MD; Meiyan Li, PhD; Peijun Yao, PhD; Rupal Shah, MD, PhD; Michael C. Knorz, MD, PhD; Xingtao Zhou, MD, PhD

Development of the Continuous Curvilinear Lenticulerrhexis Technique for Small Incision Lenticule Extraction

CCL, curvilinear lenticulerrhexis, extraction technique, lenticule dissection

2015 Jan J Refract Surg. Ishii R, Shimizu K, Igarashi A, Kobashi H, Kamiya K.

Influence of Femtosecond Lenticule Extraction and Small Incision Lenticule Extraction on Corneal Nerve Density and Ocular Surface: A 1-Year Prospective, Confocal, Microscopic Study

FLEx, SMILE, corneal nerve density, ocular surface, sub-basal nerve plexus

2014 Jan BMC Ophthalmology Zhang J, Wang Y1, Wu W, Xu L, Li X, Dou R.

Vector analysis of low to moderate astigmatism with small incision lenticule extraction (SMILE): results of a 1-year follow-up

Astigmatism, low and moderate astigmatism

2014 Eye and Vision Dan Z Reinstein, Timothy J Archer, Marine Gobbe

Small incision lenticule extraction (SMILE) history, fundamentals of a new refractive surgery technique and clinical outcomes

Small incision lenticule extraction (SMILE), Laser in situ keratomileusis (LASIK), Lenticule, Cap, Dry eye, Corneal sensation, Corneal innervation, Corneal biomechanics, Endokeratophakia

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 26 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Dez JRS Reinstein, Carp Outcomes of Small Incision Lenticule Extraction (SMILE) in Low Myopia

Low myopia, retrospective analysis

2014 Dez JRS

Mohamed A. Ali, Hidenaga Kobashi, Kazutaka Kamiya, Akihito Igarashi, Toshiyuki Miyake, Mohamed Ehab M. Elewa, Mari Komatsu, Kimiya Shimizu

Comparison of Astigmatic Correction After Femtosecond Lenticule Extraction and Wavefront-Guided LASIK for Myopic Astigmatism

Wavefront-guided, astigmatism, FLEx, LASIK

2014 Dez JCRS Chee Wai Wong, Cordelia Chan, Donald Tan, Jodhbir S. Mehta,

Incidence and management of suction loss in refractive lenticule extraction

Suction loss, complication management, retrospective,

2014 Dez PLoS One Liu YC, Pujara T, Mehta JS New Instruments for Lenticule Extraction in Small Incision Lenticule Extraction (SMILE)

Instruments, rescue, identifying layer, identifying anterior / posterior surface

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 27 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Dez JCRS Zhang J, Zhou Y, Zheng Y, Liu Q, Zhai C., Wang Y

Effect of suction on macular and retinal nerve fiber layer thickness during femtosecond lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis

Suction effect, macular and retinal nerve fibre layer thickness

2014 Dez Cornea Ganesh S, Brar S, Rao PA. Cryopreservation of extracted corneal lenticule after small incision lenticule extraction for potential use in human subjects

Lenticule storage, lenticule conservation, cryopreservation, FILI, lenticule implantation, hyperopia

2014 Nov Optom Vis Sci. Xu Y, Yang Y. Small-Incision Lenticule Extraction for Myopia: Results of a 12-Month Prospective Study

2014 Nov Ophthalmology Denoyer A., Landman E., Trinh L., Faure JF., Auclin F., Baudouin C.

Dry Eye Disease after Refractive Surgery : Comparison Outcomes of Small Incision Lenticule Extraction versus LASIK

Dry eye, comparison, LASIK, Schirmer Test, corneal staining, tear break up time, tear osmolarity measurement, severity score, corneal innervation, corneal esthesiometry, subbasal nerve imaging, in vivo confocal microscopy

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 28 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Oct JRS Lazaridis A, Droutsas K, Sekundo W. Topographic analysis of the centration of the treatment zone after SMILE for myopia and comparison to FS-LASIK: subjective versus objective alignment.

centration

2014 Oct BMC Ophthalmol Kim JR, Hwang HB, Mun SJ, Chung YT, Kim HS.

Efficacy, predictability, and safety of small incision lenticule extraction: 6-months prospective cohort study.

Prospective clinical study, efficacy, safety, age, predictors

2014 Oct Klin Monbl Augenheilkd

Kunert KS, Melle J, Sekundo W, Dawczynski J, Blum M.

One-Year Results of Small Incision Lenticule Extraction (SMILE) in Myopia.

One-year results, long term results, side effects, stability

2014 Sept Zhonghua Yan Ke Za Zhi.

Wang Y, Wu Z, Tang X, Zhang J, Dou R, Geng W, Jin Y, Zuo T.

Two millimeter micro incision lenticule extraction surgery with minimal invasion: a preliminary clinical report.

Incision size, 2 mm,

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 29 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Oct JRS Wang D, Liu M, Chen Y, Zhang X, Xu Y, Wang J, To CH, Liu Q

Differences in the corneal biomechanical changes after SMILE and LASIK

2014 Sept JRS Teus MA, Garcia-Gonzalez M.

Comparison of the visual results after small incision lenticule extraction and femtosecond laser-assisted LASIK for myopia.

- Letter -

2014 Sept JCRS Blum M, Flach A, Kunert KS, Sekundo W Five-year results of refractive lenticule extraction. FLEx, long-term results

2014 Sept JCRS Kohnen Refractive corneal lenticule extraction.

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 30 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Sept PLoS One Gao S, Li S, Liu L, Wang Y, Ding H, Li L, Zhong X.

Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis.

2014 Sept JCRS Ang M, Mehta JS, Chan C, Htoon HM, Koh JC, Tan DT

Refractive lenticule extraction: transition and comparison of 3 surgical techniques.

2014 Sept JRS Sri Ganesh, Rishika Gupta Comparison of visual and refractive outcomes following femtosecond laser assisted LASIK with SMILE in patients with myopia or myopic astigmatism

2014 Aug Acta Ophthalmol. Vestergaard AH. Past and present of corneal refractive surgery: a retrospective study of long-term results after photorefractive keratectomy, and a prospective study of refractive lenticule extraction.

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 31 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Aug Graefes Arch Pedersen IB, Bak-Nielsen S, Vestergaard AH, Ivarsen A, Hjortdal J.

Corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx smile by Scheimpflug-based dynamic tonometry.

2014 Aug PLoS One Shen Y, Zhao J, Yao P, Miao H, Niu L, Wang X, Zhou X.

Changes in corneal deformation parameters after lenticule creation and extraction during small incision lenticule extraction (SMILE) procedure.

2014 Aug Biomed Res Int.

Mastropasqua L., Calienno R, Lanzini M, Colasante M, Mastropasqua A., Mattei PA, Nubile M

Evaluation of corneal biomechanical properties modification after small incision lenticule extraction using Scheimflug-based noncontact tonometer

2014 Aug Cont Lens Anterior Eye

Ağca A, Demirok A, Cankaya Kİ, Yaşa D, Demircan A, Yıldırım Y, Ozkaya A, Yılmaz OF

Comparison of visual acuity and higher-order aberrations after femtosecond lenticule extraction and small-incision lenticule extraction

HOA higher-order aberration, FLEx, SMILE, visual acuity

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 32 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 July Curr Opin Ophthalmol.

Garcia-Zalisnak D1, Nash D, Yeu E Ocular surface diseases and corneal refractive surgery.

Dry eye, surface disease, keratorefractive corneal surgery, patient satisfaction

2014 June JCRS Kamiya K, Shimizu K, Igarashi A, Kobashi H, Sato N, Ishii R.

Intraindividual comparison of changes in corneal biomechanical parameters after femtosecond lenticule extraction and small-incision lenticule extraction.

Biomechanic, FLEx, SMILE, contralateral study, ORA

2014 June JRS Sinha Roy A, Dupps WJ Jr, Roberts CJ.

Comparison of biomechanical effects of small-incision lenticule extraction and laser in situ keratomileusis: finite-element analysis.

Biomechanic, LASIK, SMILE

2014 June

PMID: 24942120 (PubMed – in process) only in German

Seiler T.

Innovations in refractive laser surgery 2014

Summary, overview refractive laser development

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 33 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 June JCRS Wu D, Wang Y, Zhang L, Wei S, Tang X.

Corneal biomechanical effects: small-incision lenticule extraction versus femtosecond laser-assisted laser in situ keratomileusis.

2014 June JRS Ziebarth NM, Lorenzo MA, Chow J, Cabot F, Spooner GJ, Dishler J, Hjortdal JØ, Yoo SH

Surface quality of human corneal lenticules after SMILE assessed using environmental scanning electron microscopy.

Cut quality, anterior posterior surface, surface quality

2014 June JRS Ivarsen A, Hjortdal JØ Topography-guided photorefractive keratectomy for irregular astigmatism after small incision lenticule extraction.

Topoguided, topography-guided, irregular topography, PRK

2014 May Invest Ophthalmol Vis Sci

Li M1, Zhao J1, Miao H1, Shen Y1, Sun L1, Tian M1, Wadium E2, Zhou X.

Mild Decentration Measured by a Scheimpflug Camera and Its Impact on Visual Quality Following SMILE in the Early Learning Curve.

Visual quality, early learning curve, decentration, centration

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 34 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 May BMC Ophthalmol. Zhao J, Yao P, Chen Z, Li M, Shen Y, Miao H, Zhou X.

Enhancement for femtosecond lenticule extraction for visual symptomatic eye after myopia correction

FLEx, enhancement, retreatment

2014 May JRS Reinstein DZ, Archer TJ, Gobbe M Lenticule Thickness Readout for Small Incision Lenticule Extraction Compared to Artemis Three-Dimensional Very High-Frequency Digital Ultrasound Stromal Measurements

SMILE, Artemis, lenticule thickness, lenticule depth, stromal thickness

2014 May JRS Shen Y, Chen Z, Knorz MC, Li M, Zhao J, Zhou X

Comparison of Corneal Deformation Parameters After SMILE, LASEK, and Femtosecond Laser-Assisted LASIK

SMILE, LASEK, FS-LASIK, corneal deformation, CorVis ST

2014 May JRS Miao H, He L, Shen Y, Li M, Yu Y, Zhou X

Optical Quality and Intraocular Scattering After Femtosecond Laser Small Incision Lenticule Extraction

SMILE, optical quality, objective scatter index, MTF

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 35 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Apr US Ophthalmic Review

Hjortdal J, Ivarsen A New Developments in the Lenticule Extraction Procedure

Corneal refractive surgery, femtosecond laser, small incision lenticule extraction, myopia, astigmatism

2014

Graefes Arch Clin Exp Ophthalmol. (Epub Mar 2014; May;252(5):837-43)

Sekundo W, Gertnere J, Bertelmann T, Solomatin I

One-year refractive results, contrast sensitivity, high-order aberrations and complications after myopic small-incision lenticule extraction (ReLEx SMILE)

ReLEx SMILE, contrast sensitivity, higher order abberrations

2014 Apr JRS Ivarsen A, Hjortdal J Correction of Myopic Astigmatism With Small Incision Lenticule Extraction

SMILE, myopic astigmatism, astigmatic error

2014 Apr JRS Lin F, Xu Y, Yang Y Comparison of the Visual Results After SMILE and Femtosecond Laser-Assisted LASIK for Myopia

SMILE, FS-LASIK, safety, efficacy, predictability

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 36 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Mar Acta Ophthalmol Vestergaard AH

Special Issue: Past and Present of Corneal Refractive Surgery: A Retrospective Study of Long-term Results after Photorefractive Keratectomy, and a Prospective Study of Refractive Lenticule Extraction

PRK, LASIK, ReLEx flex (FLEX), ReLEx smile (SMILE), patient satisfaction

2014 Mar Journal of Ophthalmol

Agca A, Ozgurhan EB, Yildirim Y, Cankaya KI, Guleryuz NB, Alkin Z, Ozkaya A, Demirok A, Yilmaz OF

Corneal Backscatter Analysis by In Vivo Confocal Microscopy: Fellow Eye Comparison of Small Incision Lenticule Extraction and Femtosecond Laser-Assisted LASIK

SMILE, femto-LASIK, backscatter, in vivo confocal microscopy

2014 Mar JRS Xu Y, Yang Y (Epub Feb. 2014)

Dry Eye After Small Incision Lenticule Extraction and LASIK for Myopia

SMILE, LASIK, Dry Eye, Break up time, Schirmer’s test

2014 Mar. IOVS Noriega K M, Riau A K, Lwin N C, Chaurasia S S, Tan D T, Mehta J S

Early Corneal Nerve Damage and Recovery Following Small Incision Lenticule Extraction (SMILE) and Laser In Situ Keratomileusis (LASIK)

LASIK, SMILE, ReLEx, subbasal nerve, femtosecond laser

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 37 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2014 Feb. JRS Vestergaard AH, Grauslund J, Ivarsen AR, Hjortdal JØ

Central Corneal Sublayer Pachymetry and Biomechanical Properties After Refractive Femtosecond Lenticule Extraction

FLEX, SMILE, optical coherence tomography, central corneal sublayer pachymetry

2014 Feb. JRS Li M, Zhou Z, Shen Y, Knorz MC, Gong L, Zhou X

Comparison of dry eye and corneal sensitivity between small incision lenticule extraction and femtosecond LASIK for myopia.

SMILE, femto-LASIK, corneal sensation

2014 JCRS (Epub Jan. 2014)

Vestergaard AH, Grauslund J, Ivarsen AR, Hjortdal JØ

Efficacy, safety, predictability, contrast sensitivity, and aberrations after femtosecond laser lenticule extraction

FLEx, SMILE, efficacy, contrast sensitivity, higher order aberrations

2013 Ophthalmology (Epub Dec. 2013)

Ivarsen A, Asp S, Hjortdal J Safety and Complications of More Than 1500 Small-Incision Lenticule Extraction Procedures

SMILE, safety, complications

2013 Oct.Dec.

J Emmetropia Verdaguer P, El-Husseiny MA, Elies D, Gris O, Manero F, Biarnés M, Güell JL

Small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism

SMILE, Myopia, myopic astigmatism, OSI, OQAS

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 38 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2013 Dec. PoLS ONE Lim CHL; Riau AK, Lwin NC, Chaurasia SS, Tan DT, Mehta JS

LASIK following Small Incision Lenticule Extraction (SMILE) Lenticule Re-Implantation: A Feasibility Study of a Novel Method for Treatment of Presbyopia

SMILE, lenticule re-implantation, presbyopic monovision

2013 Dec. PoLS ONE Li M, Niu L, Qin B, Zhou Z, Ni K, Le Q, Xiang J, Wei A, Ma W, Zhou X

Confocal Comparison of Corneal Reinnervation after Small Incision Lenticule Extraction (SMILE) and Femtosecond Laser In Situ Keratomileusis (FS-LASIK)

SMILE, FS-LASIK, corneal reinnervation, nerve fiber density, corneal sensitivity

2013 Jun. Graefes Arch Clin Exp Ophthalmol (Epub Jun. 2013)

Vestergaard AH, Grønbech KT, Grauslund J, Ivarsen AR, Hjortdal JØ

Subbasal nerve morphology, corneal sensation, and tear film evaluation after refractive femtosecond laser lenticule extraction

Femtosecond laser, Corneal subbasal nerve morphology, Corneal sensation, Tear film evaluation

2013 Nov. Br J Ophthalmol Dong Z, Zhou X, Wu J, Zhang Z, Li T, Zhou Z, Zhang S, Li G

Small incision lenticule extraction (SMILE) and femtosecond laser LASIK: comparison of corneal wound healing and inflammation

SMILE, Femto-LASIK, inflammation, proliferation, keratocyte apoptosis,

2013 Nov. JRS Pradhan KR, Reinstein DZ, Carp GI, Archer TJ, Gobbe M, Gurung R

Femtosecond Laser-Assisted Keyhole Endokeratophakia: Correction of Hyperopia by Implantation of an Allogeneic Lenticule Obtained by SMILE From a Myopic Donor

Endokeratophakia, SMILE, extracted myopic SMILE lenticule, lenticule implantation

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 39 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2013 Oct. JRS Reinstein DZ, Archer TJ, Gobbe M Accuracy and Reproducibility of Cap Thickness in Small Incision Lenticule Extraction

SMILE, cap thickness, cap thickness, Artemis measurements

2013 Oct. PoLS ONE Li M, Zhao J, Shen Y, Li T, He L, Xu H, Yu Y, Zhou X

Comparison of Dry Eye and Corneal Sensitivity between Small Incision Lenticule Extraction and Femtosecond LASIK for Myopia

SMILE, femto-LASIK, dry eye symptoms, tear film, corneal staining, corneal sensation

2013 Oct. PoLS ONE Kamiya K, Shimizu K, Igarashi A, Kobashi H

Time Course of Optical Quality and Intraocular Scattering after Refractive Lenticule Extraction

FLEx, optical quality, intraocular scattering

2013 Oct. American Journal of Ophthalmology

Kamiya K, Shimizu K, Igarashi A, Kobashi H

Visual and Refractive Outcomes of Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction for Myopia

FLEx, SMILE, refractive outcomes

2013 Oct. Optometry & Vision Science

Demirok A, Ozgurhan EB, Agca A, Kara N, Bozkurt E, Cankaya KI, Yilmaz OF

Corneal Sensation After Corneal Refractive Surgery with Small Incision Lenticule Extraction

SMILE, F-LASIK, corneal sensation

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 40 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2013 Oct. Int Eye Sci Hu Y-K, Li W-J, Gao X-W, Guo Y-L, Dong J

[Comparison of small incision lenticule extraction and femtosecond laser assisted LASIK for myopia]

small incision lenticule extraction; femtosecond laser; LASIK; myopia

2013 Oct. JRS Yao P, Zhao J, Li M, Shen Y, Dong Z, Zhou X

Microdistortions in Bowman’s Layer Following Femtosecond Laser Small Incision Lenticule Extraction Observed by Fourier-Domain OCT

SMILE, microdistortions, OCT

2013 Aug. PoLS ONE Zhao J, Yao P, Li M, Chen Z, Shen Y, Zhao Z, Zhou Z, Zhou X

The Morphology of Corneal Cap and Its Relation to Refractive Outcomes in Femtosecond Laser Small Incision Lenticule Extraction (SMILE) with Anterior Segment Optical Coherence Tomography Observation

SMILE, cap morphology, Fourier-domain optical coherence tomography

2013 Aug. Br J Ophthalmol (Epub Dec 2012)

Kamiya K, Shimizu K, Igarashi A, Kobashi H, Komatsu M.

Comparison of visual acuity, higher-order aberrations and corneal asphericity after refractive lenticule extraction and wavefront-guided laser-assisted in situ keratomileusis for myopia

HOA, wavefront-guided LASIK, ReLEx flex, HOA induction, Hartmann-Shack aberrometry

2013 Jul. Contact Lens & Anterior Eye

Agca A, Ozgurhana EB, Demirokb A, Bozkurta E, Celika E, Ozkayaa A, Cankayaa I, Yilmaz OF

Comparison of corneal hysteresis and corneal resistance factor after small incision lenticule extraction and femtosecond laser-assisted LASIK: A prospective fellow eye study

Small incision lenticule extraction, SMILE, LASIK, Corneal hysteresis, Corneal resistance factor, Biomechanics

2013 Jul. JRS Reinstein DZ, Archer TJ, Randleman JB

Mathematical Model to Compare the Relative Tensile Strength of the Cornea After PRK, LASIK, and Small Incision Lenticule Extraction

SMILE, stromal tensile strength

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 41 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2013 Jul. JRS Sharma R, Vaddavalli PK Implications and Management of Suction Loss During Refractive Lenticule Extraction (ReLEx)

ReLEx, suction loss, femtosecond LASIK

2013 Jul. Clin Ophthalmol (Epub Jun. 2013)

Demirok A, Agca A, Ozgurhan EB, Bozkurt E, Celik U, Demircan A, Guleryuz NB, Cankaya KI, Yilmaz OF

Femtosecond lenticule extraction for correction of myopia: a 6 month follow-up study

FLEx, femtosecond laser-assisted in situ keratomileusis

2013 Jul.

Chinese Journal of Optometry Ophthalmology and Visual Science

Bai J, Xu D, Kan Q, Liu L, Zhang Y, Zhang T, Zhang Y

[Effect of correct lenticule position on femtosecond lenticule extraction clinical results]

Femtosecond laser, Refractive lenticule extraction, Center shift, Higher-order aberration, Myopia correction

2013 Jul. Clin Ophthalmol (Epub May 2013)

Ozgurhan EB, Agca A, Bozkurt E, Gencer B, Celik U, Cankaya KI, Demirok A, Yilmaz OF

Accuracy and precision of cap thickness in small incision lenticule extraction

SMILE, small incision lenticule extraction, cap thickness, flap thickness

2013 Jun PoLS ONE Riau AK, Angunawela RI, Chaurasia SS, Lee WS, Tan DT, Mehta JS

Reversible Femtosecond Laser-Assisted Myopia Correction: A Non-Human Primate Study of Lenticule Re-Implantation after Refractive Lenticule Extraction

ReLEx, re-implantation

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 42 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2013 Jun. JCRS Dong Z, Zhou X Irregular astigmatism after femtosecond laser refractive lenticule extraction

ReLEx, irregular corneal astigmatism,

2013 Jun. Graefes Arch Clin Exp Ophthalmol (Epub Feb. 2013)

Wei SS, Wang Y Comparison of corneal sensitivity between FS-LASIK and femtosecond lenticule extraction (ReLEx flex) or small-incision lenticule extraction (ReLEx smile) for myopic eyes

ReLEx smile, corneal sensitivity

2013 Jun. Acta Ophthalmol (Epub Jun. 2012)

Vestergaard A, Ivarsen A, Asp S, Hjortdal JO.

Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx(®) flex and comparison with a retrospective study of FS-laser in situ keratomileusis

ReLEx flex, FemtoLASIK, higher-order aberrations, excimer laser, femtosecond laser, lenticule extraction, myopia

2013 May JCRS Kunert K, Russmann C, Blum M, Sluyterman v. L. G

Vector analysis of myopic astigmatism corrected by femtosecond refractive lenticule extraction

VisuMax, lenticule extraction, astigmatism, vector analysis

2013 May Graefes Arch Clin Exp Ophthalmol (Epub Dec. 2012)

Gertnere J, Solomatin I, Sekundo W Refractive lenticule extraction (ReLEx flex) and wavefront-optimized Femto-LASIK: comparison of contrast sensitivity and high-order aberrations at 1 year

ReLEx flex, Femto-LASIK, Contrast sensitivity, HOA, lenticule extraction, lenticule extraction

2013 Apr. JRS Riau AK, Ang HP, Lwin NC, Chaurasia SS, Tan DT, Mehta JS

Comparison of Four Different VisuMax Circle Patterns for Flap Creation After Small Incision Lenticule Extraction

VisuMax, ReLEx smile, flap creation, circle patterns, SMILE re-treatment

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 43 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2013 Apr. Chinese Journal of Ophthalmology

Wang Y, Bao XL, Tang X, Zuo T, Geng WL, Jin Y

[Clinical study of femtosecond laser corneal small incision lenticule extraction for correction of myopia and myopic astigmatism]

SMILE, safety, efficacy, predictability, stability

2013 Apr. Chinese Journal of Ophthalmology

Wei SS, Wang Y, Geng WL, Jin Y, Zuo T, Wang L, Wu D

[Early outcomes of corneal sensitivity changes after small incision lenticule extraction and femtosecond lenticule extraction]

SMILE, FLEx, corneal sensitivity

2012 Jan. Graefes Arch Clin Exp Ophthalmol (Epub Jun. 2012)

Blum M, Kunert KS, Voßmerbäumer U, Sekundo W.

Femtosecond lenticule extraction (ReLEx®) for correction of hyperopia - first results

Hyperopia, ReLEx flex,

2012 Dec. JRS Liu H, Zhu W, Jiang AC, Sprecher AJ, Zhou X.

Femtosecond Laser Lenticule Transplantation in Rabbit Cornea: Experimental Study

lenticule transplantation, nerve regeneration,

2012 Dec. JRS Hjortdal JØ, Vestergaard AH, Ivarsen A, Ragunathan S, Asp S.

Predictors for the Outcome of Small-incision Lenticule Extraction for Myopia

patient and surgery related parameters on predictability, efficacy, safety

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 44 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2012 Nov. JRS (Epub Sep. 2012)

Vestergaard A, Ivarsen AR, Asp S, Hjortdal JØ.

Small-incision lenticule extraction for moderate to high myopia: Predictability, safety, and patient satisfaction

moderate myopia, high myopia, ReLEx smile, prospective clinical study

2012 Nov. JRS (Epub Sep. 2012)

Kamiya K, Igarashi A, Ishii R, Sato N, Nishimoto H, Shimizu K.

Early clinical outcomes, including efficacy and endothelial cell loss, of refractive lenticule extraction using a 500 kHz femtosecond laser to correct myopia

ReLEx, efficacy, endothelial cell loss

2012 Sep. JCRS Tay E, Li X, Chan C, Tan DT, Mehta JS.

Refractive lenticule extraction flap and stromal bed morphology assessment with anterior segment optical coherence tomography

stromal bed thickness, OCT, ReLEx smile, ReLEx flex

2012 Aug. JCRS Riau AK, Angunawela RI, Chaurasia SS, Tan DT, Mehta JS.

Effect of different femtosecond laser-firing patterns on collagen disruption during refractive lenticule extraction

corneal collagen architecture, different laser-firing patterns, ReLEx, visual recovery

2012 Jul. Invest Ophthalmol Vis Sci

Angunawela RI, Riau AK, Chaurasia SS, Tan DT, Mehta JS.

Refractive Lenticule Re-Implantation after Myopic ReLEx: A Feasibility Study of Stromal Restoration after Refractive Surgery in a Rabbit Model

Lenticule storage, lenticule reimplantation in vivo

2012 May Trials Ang M, Tan D, Mehta JS. Small incision lenticule extraction (SMILE) versus laser in-situ keratomileusis (LASIK): study protocol for a randomized, non-inferiority trial

Refractive surgery, Laser in situ keratomileusis, Small incision lenticule extraction

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 45 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2012 Mar. Invest Ophthalmol Vis Sci

Ang M, Chaurasia SS, Angunawela RI, Poh R, Riau A, Tan D, Mehta JS.

Femtosecond Lenticule Extraction (FLEx): Clinical Results, Interface Evaluation, and Intraocular Pressure Variation

ReLEx flex, corneal interface, ultrastructural analysis, IOP

2012 Mar. J Korean Med Assoc. Chang DJ, Joo CK [Current and future options for myopia correction]

Myopia; Myopia correction; Refractive surgical procedures; Femtosecond laser

2011 Jan. International Review of Ophthalmology [citation]

Zhao J, Chen Z, Zhou X Femtosecond laser small incision lenticule extraction for the correction of myopia

femtosecond laser, lenticule extraction, myopia

2011 Dec. Molecular Vision

Mohamed-Noriega K., Toh KP, Poh R., Balehosur D., Riau A., Htoon HM, Peh GSI, Chaurasia SS, Tan D, Mehta JS

Cornea lenticule viability and structural integrity after refractive lenticule extraction (ReLEx) and cryopreservation

ReLEx, keratocyte viability, collagen structure, structural integrity

2011 Dec. Techniques in Ophthalmology

Shah R., Shah S., Vogelsang H. All-in-One Femtosecond Laser Refractive Surgery

ReLEx smile, ReLEx flex, all-in-one Femtosecond Laser Refractive Surgery, VisuMax

2011 Nov. Molecular Vision Angunawela RI, Poh R, Chaurasia SS, Tan D, Mehta JS.

A mouse model of lamellar intrastromal femtosecond laser keratotomy: ultra-structural, inflammatory, and wound healing responses

lamellar intrastromal femtosecond laser keratotomy, VisuMax, corneal wound healing response

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 46 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2011 Sep. JRS Shah R, Shah S. Effect of scanning patterns on the results of femtosecond laser lenticule extraction refractive surgery

scanning patterns, ReLEx smile

2011 Sep. Graefes Arch Clin Exp Ophthalmol (Epub Jan. 2011)

Kunert KS, Blum M, Duncker GI, Sietmann R, Heichel J.

Surface quality of human corneal lenticules after femtosecond laser surgery for myopia comparing different laser parameters

surface quality of lenticule, laser parameters, ReLEx flex

2011 Aug. Investigative Ophthalmology & Visual Science

Riau A., Angunawela RI, Chaurasia SS, Lee WS, Tan D, Mehta JS

Early Corneal Wound Healing and Inflammatory Response after Refractive Lenticule Extraction (ReLEx)

LASIK, ReLEx , corneal topography, inflammation, extracellular matrix deposition

2011 Jul. Chin J Ophthalmol Zhou XT, Dong ZX, Yao PJ, Huang J, Xu Y, Xu HP.

[The clinical study of femtosecond lenticule extraction for myopia] ReLEx flex, myopia, predictability, safety, clinical efficacy

2011 Mar. Br J Ophthalmol (Epub Jul. 2010)

Sekundo W, Kunert KS, Blum M. Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study

ReLEx smile, myopia, myopic astigmatism, patient satisfaction

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 47 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2011 Feb. Ophthalmic Res Heichel J, Blum M, Duncker GI, Sietmann R, Kunert KS.

Surface Quality of Porcine Corneal Lenticules after Femtosecond Lenticule Extraction

ReLEx flex, VisuMax, Femtosecond laser, porcine corneal lenticules

2010 Jan. JCRS Shah R, Shah S, Sengupta S. Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery

ReLEx smile, VisuMax, myopia, refractive stability

2010 Dec. Klin Monbl Augenheilkd

Blum M, Kunert KS, Engelbrecht C, Dawczynski J, Sekundo W.

[Femtosecond Lenticule Extraction (FLEx) - Results after 12 Months in Myopic Astigmatism]

Refractive surgery, ReLEx flex, corneal ectasia, myopia, myopic astigmatism

2010 Oct. Der Ophthalmologe Blum M, Sekundo W. [Femtosecond Lenticule Extraction (FLEx)] ReLEx flex, ReLEx smile, VisuMax, LASIK, Refractive surgery

2010 Sep. Sem in Ophthalmol Kullman G, Pineda R 2nd. Alternative applications of the femtosecond laser in ophthalmology

FALK,FLAK, FS-laser-assisted posterior lamellar keratoplasty, ReLEx flex, ReLEx smile, INTACS, IEK, novel applications for femtosecond laser

Publication list - SMILE - peer reviewed papers 05| 2016

ReLEx SMILE is not approved in every country, e.g. in US FDA clinical study (IDE) is ongoing. Each publication is based on the author´s own professional opinion or on their study results. It is not necessarily a reflection of the point of view of Carl Zeiss Meditec AG and may not be in line with the clinical evaluation or the intended use of our medical devices. We therefore

recommend that you carefully assess suitability for everyday use in your practice.

Page 48 of 48 Carl Zeiss Meditec | Ophthalmic Systems | Productmanagement | Refractive Lasers | S. Schmidt

Y M Journal Author Title Keywords

2008 Jul. Graefes Arch Clin Exp Ophthalmol

Blum M, Kunert K, Schröder M, Sekundo W.

Femtosecond lenticule extraction for the correction of myopia: preliminary 6-month results

Femtosecond laser lenticule extraction, ReLEx flex, Refractive surgery, myopia

2008 Sep. JCRS Sekundo W, Kunert K, Russmann C, Gille A, Bissmann W, Stobrawa G, Sticker M, Bischoff M, Blum M.

First efficacy and safety study of femtosecond lenticule extraction for the correction of myopia: six-month results

Femtosecond laser lenticule extraction, ReLEx flex, Refractive surgery, myopia