Dibyendu De, Ph.D.

Phone: 678-474-9358 (Home) 770-330-5849 (Cell)

E-mail: dibyendu122002@yahoo.com List of Publication Patent

1. De, D., Khanna, I. K., Pillarisetti, P. Novel Cyclopentapyrimidine Compounds. (Invention disclosure filed with USPTO 2008; Provisional Patent Application filing is in progress).

2. Alexander, C. W., De, D., Khanna, I. K., Pillarisetti, P. Novel Pyrimidine Derivatives. (Invention

disclosure filed with USPTO 2008; Provisional Patent Application filing is in progress).

3. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Alexander, C., Jennepalli, S. Selective Benzylamine Derivatives and their Utility as Cholesterol Ester-Transfer Protein Inhibitors. WO 2007/075194 A1.

4. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Alexander, C., Jennepalli, S., Maitra, S., Shanavas, A.

Selective Benzylamine Derivatives and their Utility as Cholesterol Ester-Transfer Protein Inhibitors. EP 2008/1981342 A1.

5. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Maitra, S., Alexander, C. W., Jennepalli, Dager, I.

Novel Benzylamine Derivatives and their utility as Cholesterol Ester-Transfer Protein Inhibitors. US 2007/0015758 A1.

6. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Maitra, S., Alexander, C. W., Jennepalli, Dager, I.

Novel Benzylamine Derivatives as CETP Inhibitors. WO 2006/073973 A2.

7. Player, M. R., Pottorf, R. S., Rentzeperis, D., De, D. Arylidenes for the Treatment of Estrogen Related Receptor-Alpha Mediated Diseases. WO 2006/019741 A1.

8. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Maitra, S., Alexander, C. W., Jennepalli, S.. Novel

Benzylamine Derivatives and their utility as Cholesterol Ester-Transfer Protein Inhibitors. US 2006/0178514 A1.

9. Player, M. R., Pottorf, R. S., Rentzeperis, D., De, D. Use of Estrogen Related Receptor-Modulating Aryl

Ethers. US 2006/0014812 A1.

10. Krogstad, D. J., De, D. Chloroquine Analogs, their Preparation, and Methods of Preventing and Treating Plasmodial Diseases. WO 1996/40138.

11. De, D., Seth, M., Puri, S. K., Bhaduri, A. P. A process for the Preparation of 3-Arylmethyl-1-(3’-

dimethylaminopropyl)pyrrolidines. EP 1994/562185 Book Chapters

1. De, D., Khanna, I. Recent trends in HDL modulating therapies. Annual Reports in Medicinal Chemistry 2007, 42, 177-191.

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2. Krogstad, D. J., De, D. Chloroquine: modes of action and resistance, and the activity of chloroquine analogs. In: Malaria, edited by I. W. Sherman, American Society for Microbiology, Washington, D. C., 1988, 331-339.

Publication

1. Ramanathan-Girish, S.; Catz, P.; Creek, M. R.; Wu, B.; Thomas, D.; Krogstad, D. J.; De, D.; Mirsalis, J. C.; Green, C. E. Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats and Cynomolgus Macaques. International Journal of Toxicology 2004, 23(3), 179-189.

2. Riccio, E. S.; Lee, P. S.; Winegar, R. A.; Krogstad, D. J.; De, D.; Mirsalis, J. C. Genetic toxicology

testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environmental and Molecular Mutagenesis 2001, 38(1), 69-79.

3. De, D.; Krogstad, D. J. Pd(DIPHOS)2-Catalyzed Cross-Coupling Reactions of Organoborons with Free

or Polymer-Bound Aryl Halides. Organic Letters 2000, 2(7), 879-882.

4. De, D.; Krogstad, D. J.; Mague, J. T. Synthesis and crystal structure of N12-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,12-diaminododecane (AQ-40). Journal of Chemical Crystallography 1998, 28(12), 925-929.

5. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Structure-Activity Relationships for

Antiplasmodial Activity among 7-Substituted 4-Aminoquinolines. Journal of Medicinal Chemistry 1998, 41(25), 4918-4926.

6. De, D.; Byers, L. D.; Krogstad, D. J. Antimalarials: synthesis of 4-aminoquinolines that circumvent

drug resistance in malaria parasites. Journal of Heterocyclic Chemistry 1997, 34(1), 315-320.

7. De, D.; Krogstad, F. M.; Cogswell, F. B.; Krogstad, D. J. Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 1996, 55(6), 579-583.

8. Mague, J. T.; De, D.; Krogstad, D. J. An intermediate for chloroquine analogs: (E)-2-(4,7-dichloro-2-

quinolinyl)-3-(dimethylamino)-2-propenal. Acta Crystallographica, Section C: Crystal Structure Communications 1995, C51(7), 1423-5.

9. De, D.; Mague, J. T.; Byers, L. D.; Krogstad, D. J. Synthesis of (E)-2-(4,7-dichloroquinolin-2-yl)-3-

dimethylamino-2-propen-1-al and its use as a synthetic intermediate. Tetrahedron Letters 1995, 36(2), 205-8.

10. De, D.; Bhaduri, A. P.; Milhous, W. K. A novel pyrrolidonoalkaneamine (WR268954) that modulates

chloroquine resistance of Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 1993, 49(1), 113-120.

11. Batra, S.; De, D.; Seth, M.; Bhaduri, A. P. Novel Reformatsky reactions of 3-aryl-methylene-4,5-

dihydrofuran-2(3H)-ones and 4-arylmethyelene-3-methyl-isoxazole-5(4H)-ones. Journal of Chemical Research 1993, 6, 1228-1238.

12. De, D.; Seth, M.; Bhaduri, A. P. Regioselective reactions of 1,2-dehydroprogesterone: syntheses of

pregnane derivatives as possible contragestational agents. Steroids 1991, 56(4), 189-94.

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13. De, D.; Seth, M.; Bhaduri, A. P. Regioselective borohydride and Grignard reactions in (E)-3-

(arylmethylene)-2-oxotetrahydrofurans. Synthesis 1990, (10), 956-9.

14. De, D.; Seth, M.; Bhaduri, A. P. Novel synthesis of 6,7-dialkoxy-2,2-dialkyl-3-hydroxyethyl-1,2,3,4-tetrahydroquinolines. Indian Journal of Chemistry 1990, 29B(1), 70-1.

15. De, D.; Seth, M.; Bhaduri, A. P. Syntheses of substituted aminoalkanes as possible resistance

modulators. Indian Journal of Chemistry 1990, 29B(3), 231-4.

16. De, D.; Seth, M.; Bhaduri, A. P. Synthetic applications of 6-hydroxy-1-arylhexane-1,3-diones. Indian Journal of Chemistry 1989, 28B(6), 503-6.

17. De, D.; Seth, M.; Chandra, S.; Bhaduri, A. P. Reversal of chloroquine resistance: synthesis and

biological evaluation of substituted alkanolamines and diaminobutanes. Indian Journal of Chemistry 1989, 28B(2), 146-9.

National & International Conference Presentation

1. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Synthesis and antiplasmodial activities of 4-

amino-7-chloroquinoline with a terminal aliphatic N-heterocycle on the side chain. Book of Abstracts, 49th ASTMH Annual Meeting, Houston, November 2000, 20.

2. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Modified aminoquinolines (AQs) with a terminal

piperidine on the diaminoalkane side chain. Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000, MEDI-001.

3. Grimm, D. A.; De, D.; Krogstad, D. J. MALDI-TOF-MS Technique to monitor polyethylene glycol

supported Suzuki coupling for carbon-carbon bond formation. Pittcon 2000, New Orleans, March 2000.

4. De, D.; Krogstad, D. J. Palladium-catalyzed coupling of aryl bromides with aryl boranes, alkenes, and alkynes to produce byaryls, substituted alkenes, and alkynes. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), ORGN-595.

5. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Synthesis of long chain unsymmetrical N,N-

dialkyldiaminoalkanes leading to 4-aminoquinolines. Book of Abstracts, 215th ACS National Meeting, Dallas, March 29-April 2 (1998), ORGN-319.

6. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Structure and activity relationships of 4-

aminoquinolines against drug-resistant P. Falciparum. Book of Abstracts, 211th ACS National Meeting, San Francisco, CA, March 26-30, 2000, MEDI-001.

7. De, D.; Krogstad, F. M.; Cogswell, F. B.; Didier, P. J.; Byers, L. D.; Collins, W. E.; Krogstad, D. J.

Aminoquinolines that overcome drug resistance in plasmodium falciparum in vitro and in vivo. Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28 (1996), MEDI-018.

8. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Modification of the diaminoalkane side chain and

chloroquine resistance in p. falciparum. Book of Abstracts, 210th ACS National Meeting, Chicago, IL, August 20-24 (1995), (Pt. 2), MEDI-215.

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9. Cogswell, F. B.; Preslan, J.; Spurlock, J. P.; Mack, P. A.; Krogstad, F. M.; De, D.; George, W. J.; Krogstad, D. J. In vivo safety and antiplasmodial activity of chloroquine (CQ) analogs active against CQ-resistant P. falciparum in vitro. 44th ASTMH Annual Meeting, San Antonio, 1995.

10. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Synthesis of aminoquinoline analogs to define

structure-activity relationships, and identify molecules involved in antiplasmodial action and resistance. Book of Abstracts, 208th ACS National Meeting, Washington, DC, 1994, MEDI-045.

11. De, D.; Bhaduri, A. P.; Andersen, S. L.; Rossan, R. N.; Milhous, W. K. Circumvention of chloroquine

resistance by WR 268954, a newly synthesized reversal modulator. 41st ASTMH Annual Meeting, Seatle, 1992, 198.

12. De, D.; Andersen, S. L.; Gerena, L.; Kyle, D. E.; Oduola, A. M. J.; Milhous, W. K. Antifungals

synergize antimalarials. XIIIth International Congress of Tropical Medicine & Malaria, Pattaya, Thailand, 1992, Tu05-05.