pulmonary embolism
DESCRIPTION
Pulmonary embolism pathophysiologyTRANSCRIPT
When venous
thrombi are
dislodged
Embolize to : pulmonary arterial circulation
or, paradoxically, to the arterial circulation
through a patent foramen ovale or atrial
septal defect
Hypoxemia Increased arteriolar-arterial O2
tension gradient
Anatomic dead space increases
Physiologic dead space increases
Increased pulmonary vascular resistance
Impaired gas exchange
Alveolar hyperventilation
Decreased pulmonary
compliance
Increased airway resistance
RV wall tension rises and causes further
RV dilation and dysfunction
Interventricular septum bulges into
and compresses an intrinsically
normal left ventricle
RV contraction continues
even after the left ventricle
(LV) starts relaxing at end-
systole
Diastolic LV impairment
Reduced LV distensibility and impaired LV
filling during diastole
Compression of
the right
coronary artery
Diminish
subendocardial
perfusion
Limitation of
myocardial
oxygen
supply
Precipitate myocardial ischemia and RV infarction
Fall in left-ventricular cardiac output
and systemic arterial pressure
Circulatory Collapse Death