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Radiation Protection Radiation Protection in in Radiotherapy Radiotherapy Part 10 Part 10 Good Practice including Good Practice including Radiation Protection in EBT Radiation Protection in EBT Lecture 3: Radiotherapy Treatment Planning Lecture 3: Radiotherapy Treatment Planning IAEA Training Material on Radiation Protection in Radiotherapy

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Radiation Protection in Radiotherapy. IAEA Training Material on Radiation Protection in Radiotherapy. Part 10 Good Practice including Radiation Protection in EBT Lecture 3: Radiotherapy Treatment Planning. In BSS Treatment Planning is part of Clinical Dosimetry. - PowerPoint PPT Presentation

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  • Radiation Protection inRadiotherapyPart 10Good Practice including Radiation Protection in EBTLecture 3: Radiotherapy Treatment PlanningIAEA Training Material on Radiation Protection in Radiotherapy

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    In BSS Treatment Planning is part of Clinical DosimetryBSS appendix II.20. Registrants and licensees shall ensure that the following items be determined and documented: ...(b) for each patient treated with external beam radiotherapy equipment, the maximum and minimum absorbed doses to the planning target volume together with the absorbed dose to a relevant point such as the centre of the planning target volume, plus the dose to other relevant points selected by the medical practitioner prescribing the treatment;

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    and BSS appendix II.21In radiotherapeutic treatments, registrants and licensees shall ensure, within the ranges achievable by good clinical practice and optimized functioning of equipment, that: (a) the prescribed absorbed dose at the prescribed beam quality be delivered to the planning target volume; and (b) doses to other tissues and organs be minimized.

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    Treatment planning is the task to make sure a prescription is put into practice in an optimized wayPrescriptionPlanningTreatment

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    ObjectivesUnderstand the general principles of radiotherapy treatment planningAppreciate different dose calculation algorithms Understand the need for testing the treatment plan against a set of measurementsBe able to apply the concepts of optimization of medical exposure throughout the treatment planning processAppreciate the need for quality assurance in radiotherapy treatment planning

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    Contents of the lectureA. Radiotherapy treatment planning conceptsB. Computerized treatment planningC. Treatment Planning commissioning and QA

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    The need to understand treatment planningIAEA Safety Report Series 17 Lessons learned from accidental exposures in radiotherapy (Vienna 2000): About 1/3 of problems directly related to treatment planning!May affect individual patient or cohort of patients

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    A. Basic Radiotherapy Treatment Planning Conceptsi. Planning process overviewii. Patient data required for planningiii. Machine data required for planningiv. Basic dose calculation

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    i. Planning process overviewCombine machine parameters and individual patient data to customize and optimize treatmentRequires machine data, input of patient data, calculation algorithm Produces output of data in a form which can be used for treatment (the treatment plan)Patient informationPlanningTreatment unit dataTreatment plan

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    The treatment planning processIndividual patientRadiotherapy treatment unitsBeam data: radiation quality, PDD, profiles, ...Patient data: CT scan, outlinesOptimization of source or beam placementDose calculationLocalization of tumor and critical structuresPreparation of treatment sheet and record and verify dataSimulation

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    Individual patientRadiotherapy treatment unitsBeam data: radiation quality, PDD, profiles, ...Patient data: CT scan, outlinesOptimization of source or beam placementDose calculationLocalization of tumor and critical structuresPreparation of treatment sheet and record and verify dataSimulationFor eachpatientFor allpatientsChoose for eachpatient

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    ii. Patient information requiredRadiotherapy is a localized treatment of cancer - one needs to know not only the dose but also the accurate volume where it has been delivered to.This applies to tumour as well as normal structures - the irradiation of the latter can cause intolerable complications. Again, both volume and dose are important.

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    One needs to knowTarget locationTarget volume and shapeSecondary targets - potential tumour spreadLocation of critical structuresVolume and shape of critical structuresRadiobiology of structures

    Part 10, lecture 3: Radiotherapy treatment planning

  • It all comes down to the correct dose to the correct volumeDose Volume Histograms are a way to summarize this information

    Part 10, lecture 3: Radiotherapy treatment planning

    Radiation Protection in Radiotherapy

    Dose Volume HistogramsComparison of three differenttreatment techniques (red, blue and green)in terms of dose to the target and a critical structureTarget doseCriticalorgan

    Part 10, lecture 3: Radiotherapy treatment planning

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    10010010057.346300798948.228551580436.3667940257

    10010010056.825286557846.405001736735.5852726641

    10010010054.741229593645.623480375134.6648141716

    10010010054.081278221645.484543244234.2827370615

    10010010053.560263980545.224036123733.7617228204

    10010010051.997221257444.58145189333.3622785689

    10010010051.476207016343.92150052131.9208058354

    10010010050.955192775343.799930531431.2782216047

    10010010050.955192775343.018409169929.9756860021

    10010010050.955192775341.837443556829.0552275096

    10010010050.694685654741.194859326228.6731503994

    10010010050.052101424140.673845085128.5342132685

    10010010050.052101424139.753386592628.1521361584

    10010010050.052101424138.711358110527.7526919069

    10010010049.791594303637.391455366427.3706147968

    10010010049.131642931635.828412643326.9711705453

    10010010049.131642931634.664814171626.3285863147

    10010010048.610628690533.744355679125.8075720736

    10010099.958983894348.228551580432.441820076425.6686349427

    99.980859150710099.958983894347.707537339431.278221604725.4081278222

    99.917967788710099.958983894347.064953108730.618270232724.8871135811

    99.898826939410099.917967788746.405001736729.836748871124.6266064606

    99.857810833799.958983894399.898826939446.283431747129.315734630123.845085099

    99.816794728199.93984304599.898826939446.022924626628.9336575223.4630079889

    99.753903366199.835935577499.857810833744.703021882627.752691906922.9419937478

    99.671871154799.794919471799.734762516744.442514762126.971170545322.1604723862

    99.570698094199.734762516799.712887260444.182007641526.589093435222.0215352553

    99.466790626599.652730305499.652730305443.018409169925.929142063221.7610281348

    99.406633671599.589838943499.488665882840.534907954225.408127822221.2400138937

    99.283585354599.507806732199.466790626539.353942341124.105592219520.1979854116

    99.242569248999.261710098299.384758415139.093435220623.324070857919.555401181

    99.179677886999.119520931999.283585354538.693990969122.160472386219.0170197985

    98.933581252998.955456509399.056629569937.65196248720.979506773218.6349426884

    98.851549041698.851549041698.851549041637.530392497419.4164640517.9749913164

    98.810532935998.62732766498.769516830336.349426884318.374435567917.7144841959

    98.728500724698.381231030198.668343769734.404307051116.029871483216.6724557138

    98.668343769798.135134396198.545295452733.622785689513.80687738815.7693643626

    98.545295452797.886303355198.31833966832.441820076411.462313303214.2063216395

    98.31833966897.498017554998.113259139830.23619312268.735672108413.0253560264

    98.072243034197.148013453397.971069973528.01319902746.651615144111.9833275443

    97.889037762296.778868502497.867162505827.89162903794.9496352910.8197290726

    97.889037762296.245659128897.807005550827.75269190693.386592566910.1597777006

    97.826146400295.813622815997.539033660626.84960055572.344564084810.1597777006

    97.724973339595.466353121397.437860599926.32858631471.70197985419.7777005905

    97.662081977595.034316808497.292937026625.92914206321.16359847178.7356721084

    97.519892811294.583139646296.964808181325.14762070160.78152136167.5547064953

    97.251920920994.112821634696.472614913523.72351510940.64258423067.0336922543

    96.964808181393.658910065495.917530283621.37895102470.12156998965.9916637721

    96.822619015193.002652374895.526510076318.63494268840.12156998964.8106981591

    96.472614913592.614366574695.157365125413.68530739840.12156998963.9076068079

    95.876514177991.936233627794.624155751810.420284821102.4661340743

    95.362445653791.320992042994.02805501638.596734977401.5630427232

    94.870252385890.664734352493.35265647647.172629385200.659951372

    94.112821634689.844412239292.83858795225.349079541500.2605071205

    93.251483415889.39323507792.18233026173.907606807900.1215699896

    92.778430997288.857291296491.34013289223.126085446300.1215699896

    92.081157201188.201033605990.6428590961.823549843700

    91.362008148587.544775915389.94558529981.563042723200

    91.197943725986.948675179889.18542014161.563042723200

    90.724891307386.333433594988.50728719481.441472733600

    89.781520877285.551393180487.68696508161.441472733600

    89.185420141684.627163599686.82289245581.441472733600

    88.548303300483.970905909185.81936507070.65995137200

    88.135407836882.961909709984.4029422220.65995137200

    87.665089825381.772442645883.2708977058000

    87.21391266380.665007793181.9775231741000

    86.538514123278.592327253880.4790681141000

    85.939678980676.475896201978.6114681031000

    85.59240928673.131716387376.2106587187000

    84.649038855969.762926909373.8700062891000

    84.011922014766.541795411770.8539553198000

    83.106833283263.31792950767.8351699434000

    81.775177052960.671023488664.0562194088000

    79.658746000957.813568127859.640152033000

    77.134888299554.592436630154.5924366301000

    73.867271882150.367777747447.4064149189000

    67.208990730443.466134368836.5289436986000

    47.171255913233.280468130519.9201553143000

    8.558694047216.01542205572.0535396899000

    0.04101610573.67504306690000

    00.43203631290000

    000000

    four field

    six field

    simat

    four field

    six field

    simat

    Dose (%)

    Volume (cm3)

    PTV1 DVH norm to 95%

    ptv1

    Zimmerman

    ptv1rectum

    Dose (%)four fieldsix fieldsimatfour fieldsix fieldsimatd-sixfieldd-simat

    010010010010010010000

    0.51001001001001001000.52020810510.5140151515

    0.991001001001001001001.03001204821.01775

    1.491001001001001001001.55022015331.5317651515

    1.991001001001001001002.07042825852.045780303

    2.491001001001001001002.59063636362.5597954545

    2.981001001001001001003.10044030673.063530303

    3.481001001001001001003.62064841183.5775454545

    3.981001001001001001004.1408565174.0915606061

    4.481001001001001001004.66106462214.6055757576

    4.971001001001001001005.17086856525.1093106061

    5.471001001001001001005.69107667035.6233257576

    5.971001001001001001006.21128477556.1373409091

    6.471001001001001001006.73149288066.6513560606

    6.961001001001001001007.24129682377.1550909091

    7.461001001001001001007.76150492887.6691060606

    7.961001001001001001008.2817130348.1831212121

    8.451001001001001001008.7915169778.6868560606

    8.951001001001001001009.31172508219.2008712121

    9.451001001001001001009.83193318739.7148863636

    9.9510010010010010010010.352141292410.2289015152

    10.4410010010010010010010.861945235510.7326363636

    10.9410010010010010010011.382153340611.2466515152

    11.4410010010010010010011.902361445811.7606666667

    11.9410010010010010010012.422569550912.2746818182

    12.4310010010010099.861062869110012.93237349412.7784166667

    12.9310010010010099.861062869110013.452581599113.2924318182

    13.4310010010010099.861062869110013.972789704313.8064469697

    13.9310010010010099.861062869199.739492879514.492997809414.3204621212

    14.4210010010010099.861062869199.478985758915.002801752514.8241969697

    14.9210010010010099.478985758999.079541507515.523009857615.3382121212

    15.4210010010010099.34004862898.957971517916.043217962815.8522272727

    15.9110010010010099.218478638498.819034386916.553021905816.3559621212

    16.4110010010010099.079541507598.436957276817.07323001116.8699772727

    16.9110010010010099.079541507598.176450156317.593438116117.3839924242

    17.4110010010010098.697464397497.516498784318.113646221217.8980075758

    17.910010010010098.558527266496.734977422718.623450164318.4017424242

    18.410010010010098.436957276896.352900312619.143658269418.9157575758

    18.910010010010098.176450156395.692948940619.663866374619.4297727273

    19.410010010010098.176450156394.789857589420.184074479719.9437878788

    19.8910010010010098.037513025493.869399096920.693878422820.4475227273

    20.3910010010010097.777005904893.209447724921.214086527920.9615378788

    20.8910010010010097.516498784392.566863494321.734294633121.4755530303

    21.3910010010010097.255991663891.906912122322.254502738221.9895681818

    21.8810010010010097.255991663890.743313650622.764306681322.4933030303

    22.3810010010010096.734977422790.343869399123.284514786423.0073181818

    22.8810010010010096.596040291889.683918027123.804722891623.5213333333

    23.3810010010010096.213963181788.902396665524.324930996724.0353484848

    23.8710010010010095.953456061188.120875303924.834734939824.5390833333

    24.3710010010010095.814518930286.818339701325.354943044925.0530984848

    24.8710010010010095.432441820185.776311219225.875151150125.5671136364

    25.3610010010010095.293504689184.855852726626.384955093126.0708484848

    25.8610010010010095.171934699583.692254254926.905163198226.5848636364

    26.3610010010010095.032997568683.171240013927.425371303427.0988787879

    26.8610010010010094.39041333882.528655783327.945579408527.6128939394

    27.3510010010010094.129906217481.469260159828.455383351628.1166287879

    27.8510010010010093.73046196680.427231677728.975591456728.6306439394

    28.3510010010010093.469954845479.524140326529.495799561929.1446590909

    28.8510010010010093.348384855978.204237582530.01600766729.6586742424

    29.3410010010010092.688433483877.040639110830.525811610130.1624090909

    29.8410010010010092.306356373776.380687738831.046019715230.6764242424

    30.3410010010010091.646405001776.120180618331.566227820431.1904393939

    30.8410010010010091.385897881275.217089267132.086435925531.7044545455

    31.3310010010010091.125390760774.696075026132.596239868632.2081893939

    31.8310010010010090.4828065373.775616533533.116447973732.7222045455

    32.3310010010010089.82285515873.393539423433.636656078933.236219697

    32.8210010010010088.780826675972.473080930934.146460021933.7399545455

    33.3210010010010087.860368183471.569989579734.666668127134.253969697

    33.8210010010010085.637374088271.170545328235.186876232234.7679848485

    34.3210010010010084.595345606170.006946856535.707084337335.282

    34.8110010010010083.292810003569.22542549536.216888280435.7857348485

    35.3110010010010082.129211531868.56547412336.737096385536.29975

    35.8110010010010081.347690170267.922889892337.257304490736.8137651515

    36.3110010010010080.948245918766.880861410237.777512595837.327780303

    36.810010010010080.305661688166.099340048638.287316538937.8315151515

    37.310010010010079.906217436665.300451545738.80752464438.345530303

    37.810010010010079.003126085464.397360194539.327732749238.8595454545

    38.310010010010078.60368183462.695380340439.847940854339.3735606061

    38.7910010010010077.961097603362.174366099340.357744797439.8772954545

    39.2910010010010077.700590482860.993400486340.877952902540.3913106061

    39.7910010010010076.919069121260.472386245241.398161007740.9053257576

    40.2810010010010075.738103508260.211879124741.907964950741.4090606061

    40.7810010010010075.338659256759.430357763142.428173055941.9230757576

    41.2810010010010074.696075026159.04828065342.94838116142.4370909091

    41.7810010010010074.17506078558.38832928143.468589266242.9511060606

    42.2710010010010073.914553664558.127822160543.978393209243.4548409091

    42.7710010010010073.51510941357.867315039944.498601314343.9688560606

    43.2710010010099.478985758972.872525182457.224730809345.018809419544.4828712121

    43.7710010010099.478985758972.073636679456.564779437345.539017524644.9968863636

    44.2610010010098.957971517971.431052448855.783258075746.048821467745.5006212121

    44.7610010010098.957971517970.649531087255.401180965646.569029572846.0146363636

    45.2610010010098.957971517970.510593956254.880166724647.08923767846.5286515152

    45.7610010010098.957971517970.250086835754.359152483547.609445783147.0426666667

    46.2510010010098.957971517969.989579715253.317124001448.119249726247.5464015152

    46.7510010010098.957971517969.607502605152.796109760348.639457831348.0604166667

    47.2510010010098.957971517969.468565474151.875651267849.159665936548.5744318182

    47.7410010010098.819034386968.825981243551.354637026749.669469879549.0781666667

    48.2410010010098.436957276868.304967002450.712052796150.189677984749.5921818182

    48.7410010010098.436957276868.044459881949.409517193550.709886089850.1061969697

    49.2410010010098.436957276867.523445640849.01007294251.23009419550.6202121212

    49.7310010010097.394928794766.863494268848.228551580451.73989813851.1239469697

    50.2310010010097.394928794765.960402917747.968044459952.260106243251.6379621212

    50.7310010010097.394928794765.300451545746.926015977852.780314348352.1519772727

    51.2310010010097.394928794764.918374435645.883987495753.300522453552.6659924242

    51.7210010010097.394928794764.518930184145.102466134153.810326396553.1697272727

    52.2210010010097.255991663863.876345953544.841959013554.330534501653.6837424242

    52.7210010010097.255991663862.955887460944.320944772554.850742606854.1977575758

    53.2210010010097.255991663862.174366099344.06043765255.370950711954.7117727273

    53.7110010010096.873914553761.792288989243.92150052155.88075465555.2155075758

    54.2110010010094.129906217460.871830496743.4004862856.400962760155.7295227273

    54.7110010010085.776311219260.611323376243.018409169956.921170865356.2435378788

    55.210010010075.217089267159.70823202542.236887808357.430974808356.7472727273

    55.710010010071.813129558959.18721778441.698506425857.951182913557.2612878788

    56.210010010067.90552275158.527266411941.437999305358.471391018657.7753030303

    56.710010010066.203542896857.346300798941.316429315758.991599123858.2893181818

    57.1910010010064.901007294257.224730809341.055922195259.501403066858.7930530303

    57.6910010010064.119485932656.703716568340.656477943760.02161117259.3070681818

    58.1910010010063.355331712455.383813824240.395970823260.541819277159.8210833333

    58.6910010010062.712747481854.741229593639.614449461661.062027382360.3350984848

    59.1810010010061.792288989253.838138242439.353942341161.571831325360.8388333333

    59.6810010010061.271274748253.317124001438.450850989962.092039430461.3528484848

    60.1810010010060.350816255652.396665508938.31191385962.612247535661.8668636364

    60.6810010010058.648836401551.233067037237.530392497463.132455640762.3808787879

    61.1710010010058.509899270649.392150052137.009378256363.642259583862.8846136364

    61.6710010010057.346300798948.228551580436.366794025764.162467688963.3986287879

    62.1710010010056.825286557846.405001736735.585272664164.682675794163.9126439394

    62.6710010010054.741229593645.623480375134.664814171665.202883899264.4266590909

    63.1610010010054.081278221645.484543244234.282737061565.712687842364.9303939394

    63.6610010010053.560263980545.224036123733.761722820466.232895947465.4444090909

    64.1610010010051.997221257444.58145189333.362278568966.753104052665.9584242424

    64.6510010010051.476207016343.92150052131.920805835467.262907995666.4621590909

    65.1510010010050.955192775343.799930531431.278221604767.783116100866.9761742424

    65.6510010010050.955192775343.018409169929.975686002168.303324205967.4901893939

    66.1510010010050.955192775341.837443556829.055227509668.823532311168.0042045455

    66.6410010010050.694685654741.194859326228.673150399469.333336254168.5079393939

    67.1410010010050.052101424140.673845085128.534213268569.853544359369.0219545455

    67.6410010010050.052101424139.753386592628.152136158470.373752464469.535969697

    68.1410010010050.052101424138.711358110527.752691906970.893960569670.0499848485

    68.6310010010049.791594303637.391455366427.370614796871.403764512670.553719697

    69.1310010010049.131642931635.828412643326.971170545371.923972617771.0677348485

    69.6310010010049.131642931634.664814171626.328586314772.444180722971.58175

    70.1310010010048.610628690533.744355679125.807572073672.96438882872.0957651515

    70.6210010099.958983894348.228551580432.441820076425.668634942773.474192771172.5995

    71.1299.980859150710099.958983894347.707537339431.278221604725.408127822273.994400876273.1135151515

    71.6299.917967788710099.958983894347.064953108730.618270232724.887113581174.514608981473.627530303

    72.1199.898826939410099.917967788746.405001736729.836748871124.626606460675.024412924474.1312651515

    72.6199.857810833799.958983894399.898826939446.283431747129.315734630123.84508509975.544621029674.645280303

    73.1199.816794728199.93984304599.898826939446.022924626628.9336575223.463007988976.064829134775.1592954545

    73.6199.753903366199.835935577499.857810833744.703021882627.752691906922.941993747876.585037239975.6733106061

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    74.699.570698094199.734762516799.712887260444.182007641526.589093435222.021535255377.615049288176.6910606061

    75.199.466790626599.652730305499.652730305443.018409169925.929142063221.761028134878.135257393277.2050757576

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    76.0999.283585354599.507806732199.466790626539.353942341124.105592219520.197985411679.165269441478.2228257576

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    81.0798.072243034197.148013453397.971069973528.01319902746.651615144111.983327544384.346542168783.3424166667

    81.5697.889037762296.778868502497.867162505827.89162903794.9496352910.819729072684.856346111783.8461515152

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    85.0596.964808181393.658910065495.917530283621.37895102470.12156998965.991663772188.487398685787.4339772727

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    86.0496.472614913592.614366574695.157365125413.68530739840.12156998963.907606807989.517410733888.4517272727

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    91.0190.724891307386.333433594988.50728719481.44147273360094.68827929993.5610378788

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    92.0189.185420141684.627163599686.82289245581.44147273360095.728695509394.5890681818

    92.5188.548303300483.970905909185.81936507070.6599513720096.248903614595.1030833333

    9388.135407836882.961909709984.4029422220.6599513720096.758707557595.6068181818

    93.587.665089825381.772442645883.270897705800097.278915662796.1208333333

    9487.21391266380.665007793181.977523174100097.799123767896.6348484848

    94.586.538514123278.592327253880.479068114100098.319331872997.1488636364

    94.9985.939678980676.475896201978.611468103100098.82913581697.6525984848

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    96.4884.011922014766.541795411770.8539553198000100.379355969399.1843636364

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    99.4767.208990730443.466134368836.5289436986000103.4902004381102.2581742424

    99.9747.171255913233.280468130519.9201553143000104.0104085433102.7721893939

    100.468.558694047216.01542205572.0535396899000104.5202124863103.2759242424

    100.960.04101610573.67504306690000105.0404205915103.7899393939

    101.4600.43203631290000105.5606286966104.3039545455

    101.96000000106.0808368018104.817969697

    Chart for ptv2

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    00.48409829030000

    000000

    Four Field

    Six Field

    SIMAT

    four field

    six field

    simat

    Dose (%)

    Volume (%)

    PTV2 and Rectum DVHs normalised to 95% Dose

    ptv2

    zimmerman

    ptv2rectum

    Dose (%)Four FieldSix FieldSIMATfour fieldsix fieldsimatd(six field)d(simat)d(simat)Dose (gy)Dose (gy)Dose (gy)

    0100100100100100100000000

    0.51001001001001001000.5218657290.51457204770.40136619720.390.40705526870.4013661972

    0.991001001001001001001.03329414351.01885265440.79470507040.77220.80596943190.7947050704

    1.491001001001001001001.55515987251.53342470211.19607126761.16221.21302470061.1960712676

    1.991001001001001001002.07702560162.04799674971.59743746481.55221.62007996921.5974374648

    2.491001001001001001002.59889133062.56256879741.9988036621.94222.02713523791.998803662

    2.981001001001001001003.11031974513.06684940412.39214253522.32442.42604940122.3921425352

    3.481001001001001001003.63218547413.58142145182.79350873242.71442.83310466982.7935087324

    3.981001001001001001004.15405120324.09599349953.19487492963.10443.24015993853.1948749296

    4.481001001001001001004.67591693224.61056554713.59624112683.49443.64721520713.5962411268

    4.971001001001001001005.18734534675.11484615383.989583.87664.04612937043.98958

    5.471001001001001001005.70921107575.62941820154.39094619724.26664.45318463914.3909461972

    5.971001001001001001006.23107680476.14399024924.79231239444.65664.86023990774.7923123944

    6.471001001001001001006.75294253386.65856229695.19367859155.04665.26729517645.1936785915

    6.961001001001001001007.26437094827.16284290365.58701746485.42885.66620933965.5870174648

    7.461001001001001001007.78623667737.67741495125.9883836625.81886.07326460835.988383662

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    8.951001001001001001009.34139654989.21083965337.18445492966.9817.28628930897.1844549296

    9.451001001001001001009.86326227899.7254117017.58582112687.3717.69334457757.5858211268

    9.9510010010010010010010.385128007910.23998374867.98718732397.7618.10039984627.9871873239

    10.4410010010010010010010.896556422410.74426435548.38052619728.14328.49931400948.3805261972

    10.9410010010010010010011.418422151411.2588364038.78189239448.53328.90636927818.7818923944

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    Dose (%)

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