D Raghunadharao

Professor of Medical OncologyNizam’s Institute of Medical Sciences

Hyderabad 500 082 IndiaTel: 91 40 23489368 Fax: 91 40 23371747

Mobile: 91 9246571537 Email: rdigumarti@gmail.com

ACHIEVEMENTS:

Established the 1st Medical Oncology Department and a comprehensive cancer care center for the State – 1989

Established a Hospital Cancer Registry -1989

Established a subsidised cancer pharmacy – 1992

Established a Clinical Research Facility – 1992

Pioneered phase 1 trials in Cancer new cancer drugs: completed over 80 clinical trials since 1993 in all phases

First ACRP Certified Clinical Research Physician in India 2004

Started a DM Medical Oncology Course in 2005

Founded the Medical Oncologists Forum for the State – 2005

Started the Twin Cities Cancer Club – 2004

INDOX Collaboration – funding from the University of Oxford for an early phase cancer clinical trials unit –Facilities, training and personnel - 2005

Started the 1st hematopoietic stem cell transplant unit – 2003

Started the Childhood Cancer Study Group – 2007

Established the 1st Hospital Based Cancer Registry in AP (ICMR – NCRP)– 2011

Established the 1st Population based Cancer Registry in AP (ICMR – NCRP)- 2012

National Coordinator for training government doctors in the country in Cancer Screening and Prevention under the National Rural Health Mission’s Non-communicable disease program – 2011 – 2013

Collaboration with Breast International Group, Osmania University, Central University, NIN, CCMB and ICRISAT in pre-clinical & clinical research

EDUCATION

DM (Medical Oncology Fellowship) 1987-89: Cancer Institute, University of Madras, India

MD (Internal Medicine Residency) 1982-85: Post Graduate Institute of Medical Education & Research, Punjab University, Chandigarh, India

MBBS: 1976-81: Andhra Medical College, Andhra University, Visakhapatnam, India

ADVANCED TRAINING

Experimental Biotherapeutics: Gene and Cell Transfer therapy – Course at the University of Oxford, UK 1 – 11 November 2011

National Assessment and Accreditation Council, University Grants Commission, Bengaluru – Training in Assessment and Accreditation of Institutes imparting Medical Education – Nov 2010

Statistics for Randomised Clinical Trials – University of Oxford, UK May 2007

Phase 1 Clinical Trials Workshop at the University of Oxford, UK May 2006

Certified Clinical Trial Investigator of the Association of Clinical Trial Investigators 2004 [Re-certified]

CERTIFIED MEMBER of the European Society for Medical Oncology 1998

USMLE Certification by ECFMG, USA 1996 (Parts 1 & 2)

ICRETT Fellowship, International Union Against Cancer 1998: Training in Palliative Chemotherapy of Gynaecologic Cancers and Hospice Care at the Institute for Cancer Studies, University of Birmingham, Birmingham, UK.

ICRETT Fellowship, International Union Against Cancer 1993: Advanced Training in Allogenic Bone Marrow Transplantation at the Princess Margaret Hospital, Toronto, Canada.

Training in DNA diagnostics & Molecular Biology Techniques for the clinician – Atomic Energy Commission of India 1992

PROFESSIONAL EXPERIENCE

Feb 2003 – till date Professor of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad

1998 - 03: Additional Professor, Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad. This Autonomous Health Sciences University Hospital caters to a population of 80 million, with 31 clinical and para- clinical departments. It is the apex referral hospital for the State. The institute has a comprehensive cancer care center with medical, radiation and surgical oncology divisions. The average patient load is 2000 new patients.

1998: UICC/ ICRETT Fellow at the Cancer Research Campaign's Institute for Cancer Studies, University of Birmingham, U. K, in Gynaecologic Oncology & Palliative Care, under Dr. Christopher J Poole.

1989-98: Assistant and later Associate Professor in Medical Oncology, at the Nizam’s Institute of Medical Sciences, Hyderabad, India.

1985-87: Senior Resident (Registrar) in Medical Oncology at the Tata Memorial Hospital, Bombay, India, under Dr. S. H. Advani. Learnt basics of oncology. Witnessed allogenic and autologous BMT. Learnt elements of cytochemistry, cytogenetics, flowcytometry and long term leukemic cell culture.

1983 – 85 Lady Tata Trust Senior Research Fellow: worked on Mode of acquisition of Clostridium difficile in neonates. MD Thesis

1983: Senior Research Fellow of the Indian Council of Medical Research, under Prof. Sehgal, PGIMER, Chandigarh – Immunophenotyping of lymphomas

POST DOCTORAL

1 Jan 2011 to 31 Dec 2012: a. Monitoring Minimal Residual Disease and drug resistance in

Chronic Myeloid Leukemiab. Xenobiotic Metabolising enzyme polymorphism and breast

cancer susceptibility

PhD guide:

1. Evaluation of vitamin A status using conjunctival impression cytology (awarded and published)

2. The Effect of TPMT genotype on 6MP metabolism and toxicity in children with ALL (Awarded & Published)

3. Evaluation of MDR1 gene expression profile in acute myeloid leukemia by RQ-PCR at diagnosis and at relapse (Completed)

4. Assessment of Aflatoxin Exposure among Indian Populations (Awarded & published)

5. Genetic Polymorphism of CYP-2D6 and susceptibility to hematological malignancies (Awarded & published)

6. Glutathione S Transferase polymorphism in acute leukemias (Awarded & published)

7. Apolipoprotein E Polymorphisms in breast cancer (Awarded & publidhed)

Doctor of Medicine:

1. Identification of hematological malignancies by scatter plots and histograms using VCS Technology of automated cell counter – Co guide for MD Pathology Thesis 2012

2. A clinical profile of Superior vena caval obstruction syndrome – MD General Medicine, Nizam’s Institute of Medical Sciences, Hyderabad. 2002

3. Ocular changes in chronic myeloid leukemia – MD Ophthalmology, University of Health Sciences, Andhra Pradesh. 2000

4. Immunophenotyping of bone marrow in Hodgkin’s Lymphoma – MD Pathology, Nizam’s Institute of Medical Sciences, Hyderabad. 2000

5. An Analysis of Acute Promyelocytic Leukemia treated with all-trans retinoic acid – MD Medicine – Nizam’s Institute of Medical Sciences, Hyderabad. 2000

6. Chemotherapy induced bone marrow changes. MD Pathology from Nizam’s Institute of Medical Sciences, Hyderabad. 1996

7. A Survey of attitudes of health care givers towards cancer. M Sc Dietetics of the Avinashalingam University, Coimbatore. 1995

8. Ototoxicity of cDDP. MS (ENT) of Osmania University, Hyderabad. 1992

9. cDDP induced peripheral neuropathy. DM (Neurology) of the Nizam’s Institute of Medical Sciences, Hyderabad. 1992.

ORATIONSK L Gupta Oration – Annual Conference of the Indian Association of Clinical Biochemists – Tumour Markers in Cancer- Ranchi Feb 2013

ISMPO Oration – Indian Cancers, Indian Solutions - Mid Term Conference of the Indian Society for Medical & Paediatric Oncology, Vizag 16 Feb 2012

Muthuswamy Naidu Memorial Oration on Breast Cancer, Sri Ramakrishna Institute of Oncology and Research, Coimbattore – 20 September 2009

Dr. P S Ghatge Memorial Oration on The Role of General Practitioners in Prevention and Treatment of Cancer Indian Medical Association, Hyderabad on Saturday, the 23rd of April 2005

Yellapragada Subbarao Commemorative Lecture on “Cancer: etiology, diagnosis and prevention” at Bhimavaram, 12 January 2003

LICENSES AND CERTIFICATION: MRC no. 14000 Andhra

Editorial Board:Indian J CancerJournal of ISMPO JCO Indian Edition South Asian Journal of CancerAmerican Journal of Robotic Surgery

AWARDS & HONORS

Honorary Senior Research Fellow of the Department of Clinical Pharmacology, University of Oxford, United Kingdom 2005 -2009UICC/ICRETT Fellowship (1993 & 98) ICMR Sr. Res. Fellowship (1983)

Lady Tata Senior Research Fellowship (1983) Honors in Chemistry (1977)Rotary International Nitish Lahari Gold Medal (1979)National Merit Scholarship (1972) State Merit Scholarship (1974)

CIVIC HONORS2009 Dhanwantri Foundation – Sushruta Award for public service in medicine 2007 ANR Swarna kankanam for public service and professional excellence2005 Madras Telugu Academy Samaikhya Bharat Gaurav Puraskar 2005 Ugadi Satkaramu [New Year Awards]: Megacity Navakala Vedika 2005 Kinnera - Sri Parthava Naama Ugadi Puraskaram 2005 Distinguished Couples of the Twin Cities

MEMBERSHIP TO PROFESSIONAL BODIES

Fellow & Life Member, International Union Against Cancer - UICC

Member, Selection Committee – Conquer Cancer Foundation Awards - American Society for Clinical Oncology 2013-2015

Member, International Affairs Committee – American Society for Clinical Oncology 2007-2010

American Association for Cancer Research

Association of Physicians of India Indian Society of Oncology

Indian Academy of Paediatrics Indian Society for Medical Informatics

Association of Medical Physicists Indian Association of Medical and

Of India Pediatric Oncologists Indian Association of Cancer Research

Indian Society for Clinical Research – Executive MemberEuropean Society of Medical Oncology

Association of Clinical Research ProfessionalsIndian Cooperative Oncology Network

Indian Collaborative Clinical Research Organisation (Founder Trustee)

Founder – Medical Oncologists Forum, Twin Cities Cancer Club

Founder-Treasurer – Cancer Institute Alumni Association 2013

Founder-Member – Teen & Young Adult Oncology 2013

Founder & Managing Trustee – Digumarti Foundation

REFERENCES

1. Professor David Kerr, CBE, MA MD DSc FRCP (Glas & Lon) F Med SciRhodes Professor of Cancer Therapeutics and Clinical PharmacologyDirector, National Translational Cancer Research NetworkHead of Department of Clinical Pharmacology, University of OxfordDepartment of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE UK

2. Prof. Ian Tannock, MD, FRCP(C), Ph D Daniel Bergsagel Professor in Medical Oncology, Department of Medical Oncology, Princess Margaret Hospital and the University of Toronto, Toronto, Canada

PUBLICATIONS2013

1. JAK2 V617F mutation: a marker for cml progression? Manjula G, Prajitha EM, Sailaja K, Raghunadharao D, Anuradha C, Sugunakar V, Sandhya A, Nageswara Rao S, Vishnupriya S. Journal of Cell and Tissue Research Vol. 13(1) 3439-3443 (2013)

2. An Open-Label Study of the Safety and Tolerability of Pazopanib in Combination with FOLFOX6 or CapeOx in Patients with Colorectal Cancer (accepted for publication in Investigational New Drugs)

3. Association of E-cadherin single nucleotide polymorphisms with the increased risk of breast cancer: A study in south Indian women (submitted for publication in Genetic Testing and Molecular Biomarkers)

2012,

1. Phase 1 Dose Escalation Study of Rigosertib by 2-, 4-, or 8-hour Infusion Twice Weekly in Patients with Advanced Cancer (Accepted for publication in Indian Journal of Cancer manuscript number IJC_223_12)

2. Jorge Cortes, Jeff H. Lipton, Delphine Rea, Raghunadharao Digumarti, Charles Chuah, Nisha Nanda, Annie-Claude Benichou, Adam R. Craig, Mauricette Michallet, Franck E. Nicolini and Hagop Kantarjian. Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation. Blood 2012-03-415307; published ahead of print August 15, 2012, doi:10.1182/blood-2012-03-415307

3. B H Srinivas, T Roshni Paul, Shantveer G Uppin, Megha S Uppin, Rachel T Jacob & D Raghunadharao. Morphologic Changes in the Bone Marrow in Patients of Chronic Myeloid Leukemia (CML) treated with Imatinib Mesylate Indian J Hematol Blood Transfus 2012, 28:162-169

4. Ruth Pettengell, Bertrand Coiffier, Geetha Narayanan, Fernando Hurtado de Mendoza, Raghunadharao Digumarti, Henry Gomez, Pier Luigi Zinzani, Gary Schiller, David Rizzieri, Giles Boland, Paul Cernohous, Lixia Wang, Christine Kuepfer, Igor Gorbatchevsky, Jack W Singer: Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients withrelapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. Lancet Oncology May 30, 2012 DOI:10.1016/S1470-2045(12)70212-7

5. Patchva Dorababu & Shaik Mohammad Naushad & Vijay Kumar Kutala & Raghunadharao Digumarti. Impact of age, gender and haplotypes of thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genes on 6-mercaptopurine toxicity in children with acute lymphoblastic leukemia European

Journal of Clinical Pharmacology: Volume 68, Issue 5 (2012), Page 885-886

6. Dorababu P, Nagesh N, Linga VG, Gundeti S, Kutala VK, Reddanna P, Digumarti R. Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. Eur J Clin Pharmacol. 2012;68(4):379-87.

7. Dorababu P, Naushad SM, Linga VG, Gundeti S, Nagesh N, Kutala VK, Reddanna P, Digumarti R. Interaction between thiopurine and folate metabolic pathway genetic variants determines 6-MP mediated hematological toxicity in children with acute lymphoblastic Leukemia. Pharmacogenomics Journal. [In press, 2012].

2011

1. Dunna NR, Anuradha C, Vure S, Sailaja K, Surekha D, Raghunadharao D, Rajappa S, Vishnupriya S. NQO1*2 [NAD(P)H: quinone oxidoreductase 1] polymorphism and its influence on acute leukemia risk Biology and Medicine, Vol 3 (3): 19-25, 2011

2. Naushad Shaik Mohammad, Pavani Addepalli, Rupasree Yedluri, Shree Divyya Parvathaneni, Deepti Sripurna, Digumarti Raghunadharao, Gottumukkala Suryanarayana Raju, Prayaga Aruna, Kutala Vijay Kumar. Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer (MS# MC-11-0287), accepted for publication in Molecular Carcinogenesis

3. S. Anitha, F. Waliyar, A. S. Reddy, Ratna Rao, Raghunadharao D and P. Lava Kumar. The development of a simple enzyme-linked immunosorbent assay for quantitative estimation of aflatoxin B1 albumin adduct in humans. CURRENT SCIENCE, VOL. 101, NO. 7, 10 OCTOBER 2011

4. Anantabhushan A Ranade, Shona Nag, Ranjan Mahopatra, Suresh H Advani, P P Bapsy, D Raghunadharao, Vinod Raina, Anish Maru, K Sambhasiviah, Purvish M Parikh, V P Gangadharan, Chanchal Goswami, J S Shekhon, Shekhar Patil and Ashish Bakshi. A multicenter phase II study of cremophor free, polymeric Nanoparticle formulation of Paclitaxel in locally advanced and /or metastatic breast cancer submitted to Breast Cancer Research MS ID 6693975345885539

5. Raghunadharao Digumarti, Yenyun Wang, Ganapathi Raman, Dinesh C. Doval, Suresh H. Advani, Pramod K. Julka, Purvish M. Parikh, Shekhar Patil, Shona Nag, Jayaprakash Madhavan, Ajay Bapna, Annantbhushan A. Ranade, Atul Varadhachary, and Rajesh Malik. A randomized, double-blind, placebo-controlled Phase 2 study

of single agent oral talactoferrin in patients with locally advanced or metastatic non-small cell lung cancer that had progressed following previous chemotherapy. J Thorac Oncol. 2011; 6: 1098–1103

6. Raghunadharao D and Senthil J Rajappa. Management of Aspergillosis Fungal Facts Volume 7 July 2011

7. Pragnya Coca, Sadashivudu G., Shantiveer Uppin, Raghunadharao D Metastatic adenocarcinoma in a young male, 12 years after treatment of primary nonseminomatous germ cell tumor. IJMPO 2011, 32: 115 - 117

2010

1. D Surekha, K Sailaja, D Nageswararao, T Padma, Raghunadharao D, S Vishnupriya Association of a CYP17 Genen Polymorphism with development of Breast Cancer in India Asian Pacific J Cancer Prevention, Vol 11, 2010, 1653-1657

2. D Surekha, K Sailaja, D Nageswararao, T Padma, D Raghunadharao and S Vishnupriya. CYP2D6*4 polymorphisms and breast cancer risk. Biology and Medicine, Vol 2 (4): 49-55, 2010

3. Nageswararao Dunna, Senthil Rajappa, Raghunadharao Digumarti, Sugunakar Vure, Sailaja Kagiata, Surekha Damineni, V R Rao, Satish Kumar Yadav, Rajsekhar Reddy Ravuri, Vishnupriya Satti. Fms like tyrosine kinase (FLT3) and Nucleophosmin 1 (NPM1) mutations in de novo normal karyotype acute myeloid leukemia (AML) Asian Pacific J Cancer Prev, 11, 1- 6

4. Shaik Mohammad Naushad, Addepalli Pavani, Raghunadha Rao Digumarti, Suryanarayana Raju Gottumukkala, Vijay Kumar Kutala Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer Mol Biol Rep 2010 DOI 10.1007/s11033-010-0631-z

5. Naushad Shaik Mohammad, Rupasree Yedluri, Pavani Addepalli, Suryanarayana Raju Gottumukkala, Raghunadha Rao Digumarti, Vijay Kumar KutalaAberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer Mol Cell Biochem DOI 10.1007/s11010-010-0670-8

6. Rajender Singh, Francis Amrithraj, Pooja Singh, Krupakar Nallala, Surekha Damineni, Gopal Reddy, D Raghunadharao, Lakshman Rao, S Ramachandra, S Vishnupriya, K Ramalingam, K Satyamoorthy, Kumaraswamy Thangaraj CAG repeat length polymorphism in the androgen receptor gene and breast cancer risk: data on Indian women and survey from the world Breast Cancer Research and Treatment 2010 Nov; 1263:10

7. Nageswararao D, Manjulla G, Sailaja K, Surekha D, Raghunadharao D, Senthil R and Vishnupriya S. Association of CYP2D6*4

polymorphism with acute leukemia J of Cell and Tissue Research 2010 10 (2): 2201 – 2205 – Best paper award

8. Purvish M. Parikh, MD, A.A. Ranade, MD, Ashok Vaid, MD, Suresh H. Advani, MD, Raghunadharao Digumarti, DM, Jayaprakash Madhavan, MD, Shona Nag, MD, Ajay Bapna, MD, Jagdev Singh Sekhon, MD, Shekhar Patil, DM, Preeti M. Ismail, PhD, MBA, Yenyun Wang, MD, Atul Varadhachary, MD, PhD, Rajesh Malik, MD. A randomized, double-blind, placebo-controlled Phase 2 study of single agent oral talactoferrin in patients with locally advanced or metastatic non-small cell lung cancer that had progressed following previous chemotherapy (Submitted for publication to JCO)

9. An Open-Label Pharmacokinetic Study Of The Safety And Tolerability Of Votrient In Combination With FOLFOX6 Or CapeOx In Patients With Colorectal Cancer (Submitted for publication to Annals of Oncology)

10. A. U. Buzdar, B. Xu, R. Digumarti, L. Goedhals, X. Hu, V. Semiglazov, S. Cheporov, E. Gotovkin, S. Hoersch, K. Rittweger, D. W. Miles, J. O’Shaughnessy and S. Tjulandin on behalf of the NO16853 trial group. Part I: Randomized phase II non-inferiority study (NO16853) of two different doses of capecitabine in combination with docetaxel for locally advanced/metastatic breast cancer. Annals of Oncology (Submitted for publication)

11. T Roshni Paul, Shantiveer G Uppin, Megha S Uppin, Rachel T Jacob, D Raghunadharao and Senthil J Rajappa Evaluation of cytopenias occurring in imatinib treated chronic myeloid leukemia (CML) patients Indian J of Hemat & Blood Transfusion 2010 Nov

12. Jadhav MP, Bamba A, Shinde VM, Gogtay N, Kshirsagar NA, Bichile LS, Mathai D, Sharma A, Varma S, Digumarti R. Liposomal amphotericin B (FungisomeTM) for the treatment of cryptococcal meningitis in HIV/AIDS patients in India: A multicentric, randomized controlled trial J Postgrad Med 2010; 56: 71-5

2009

1. Ashwani Tandon, Sundaram Challa, M. Shanmugam, Swarnalatha Gopalan, Roshni T. Paul, Raghunadharao Digumarthi. Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunocompetent individuals. Neurology India; Jan-Feb 2009, 57: 36-40

2. Surekha D, Sailaja K, Rao D Nageswara, Padma T, Raghunadharao D, Vishnupriya S Association of CYP1A1*2 Polymorphisms with breast cancer risk : A case control study. Ind J of Medical Research. 2009; 63: 10 - 17

2008

1. Peter G. Pappas,Coleman M. F. Rotstein, Robert F. Betts, Marcio Nucci,1Deepak Talwar,Jan J. De Waele,Jose A. Vazquez, Bertrand F.

Dupont, David L. Horn,Luis Ostrosky-Zeichner,Annette C. Reboli, Byungse Suh, Raghunadharao Digumarti, Chunzhang Wu, Laura L. Kovanda, Leah J. Arnold, and Donald N. Buell. Micafungin versus Caspofungin for Treatment of Candidemia and Other Forms of Invasive Candidiasis. Clinical Infectious Diseases 2007; 45:883–93

2. Surekha D, Vishnupriya S, Sailaja K, Nageswara Rao D and Raghunadharao D Influence of Apolipoprotein E Gene Polymorphism on the Risk for Breast Cancer. Int J Hum Genet, 8(3): 277-282 (2008)

3. Luc Yves Dirix, Jorge Ignacio, Shona Nag, Poonamally Bapsy, Henry Gomez, Digumarti Raghunadharao, Robert Paridaens, Stephen Jones, Silvia Falcon, Marina Carpentieri, Antonello Abbattista, and Jean-Pierre Lobelle. Treatment of Advanced Hormone-Sensitive Breast Cancer in Postmenopausal Women With Exemestane Alone or in Combination With Celecoxib. J Clin Oncol 26:1253-1259

4. Rajappa S, Gundeti S, Talluri M and Digumarti R. Chemotherapy for advanced lung cancer – A 5-year experience. Ind J Cancer 2008; 45: 20 – 26.

5. Senthil Rajappa ; Lalit Varadpande; Tara Paul ; Rachel Jacob; Raghunadharao Digumarti. Imatinib mesylate in early chronic phase chronicmyeloid leukemia: Experience from a developing country. Leukemia andLymphoma,2008; 49:3, 554 – 558

6. Surekha, D, Vishnupriya, S, Sailaja, K., Nageswararao, D, Padma, T and Raghunadharao, D Role of GSTP1 gene polymorphism in the developmentof breast cancer: a case control study. Journal of Cell and Tissue Research Vol. 8(3) 1613-1616 (2008)

2007

1. Senthil Rajappa, Norman Bethune, Sadasivudu G, Lalit Varadpande, Raghunadharao Digumarti. Acute coronary syndrome as the presenting feature of Cardiac rhabdomyosarcoma. J Clin Oncol. 2007 Feb 1; 25(4): 449-51

2. PM Parikh, AA Ranade, AK Vaid, SH Advani, D Raghunadharao, S Nag, Oral talactoferrin extends survival in patients with recurrent NSCLC in a randomized placebo-controlled Phase 2 trial.A Varadhachary, JP Madhavan, LF0201 Group, Y Wang. ASCO Proceedings 2007

3. Senthil Rajappa, Norman Bethune, Shantiveer Uppin, Aruna Prayaga, Rupam Borgohain, D Raghunadharao. Reversible paraneoplastic syndrome as the presenting feature of ovarian teratoma-A clinicopathological correlate. Annals of the Indian Academy of Neurology 2007:10; 52-4

4. Senthil Rajappa, Shantiveer Uppin, D Raghunadharao. Testicular relapse of Primary central nervous system lymphoma. Leukemia and Lymphoma; 46 (5): 1023 – 1025.

5. Senthil Rajappa, Satish Rao, Mahendra Parage, D Raghunadharao. Primary Renal Lymphoma Presenting as Paraneoplastic Limbic Encephalitis. J Clin Oncol 2007; 25(24): 3783-3785

6. Senthil Rajappa, Lalit Varadpande, Roshni Paul, Raghunadharao Digumarti. Immune Thrombocytopenia with Imatinib Mesylate. Leukemia and Lymphoma 2007

7. Senthil Rajappa, Lalit Varadpande, Roshni Paul, Rachel Thomas Jacob, D Raghunadharao. Sub optimal responses of Indian patients with chronic phase chronic myeloid leukemia to imatinib mesylate. National Medical Journal of India

8. Senthil Rajappa, Krishna Mohan, Shantveer Uppin, D Raghunadharao. Gastrointestinal Stromal Tumor: A single institution experience of 50 cases. Indian Journal of Gastroenterology

9. Phase III study of pemetrexed plus cisplatin versus gemcitabine plus cisplatin in chemonaive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). ECCO conference in Barcelona, Spain September 23-27, 2007. Submitted for publication in NEJM 2007 [under review]

10.Ernst-Rüdiger Kuse, Ploenchan Chetchotisakd, Clovis Arns da Cunha, Markus Ruhnke, Carlos Barrios, Digumarti Raghunadharao, Jagdev Singh Sekhon, Antonio Freire, Venkatasubramanian Ramasubramanian, Ignace Demeyer, Marcio Nucci, Amorn Leelarasamee,Frédérique Jacobs, Johan Decruyenaere, Didier Pittet, Andrew J Ullmann, Luis Ostrosky-Zeichner, Olivier Lortholary, Sonja Koblinger,Heike Diekmann-Berndt, Oliver A Cornely, for the Micafungin Invasive Candidiasis Working Group L. Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial ancet April 26, 2007 DOI:10.1016/S0140-6736 (07) 60605-9

11.Digumarti Raghunadharao, Jagdev Singh Sekhon, Antonio Freire, Venkatasubramanian Ramasubramanian, Ignace Demeyer, Marcio Nucci, Amorn Leelarasamee,Frédérique Jacobs, Johan Decruyenaere, Didier Pittet, Andrew J Ullmann, Luis Ostrosky-Zeichner, Olivier Lortholary, Sonja Koblinger,Heike Diekmann-Berndt, Oliver A Cornely, for the Micafungin Invasive Candidiasis Working Group. Micafungin versus caspofungin for candidemia and other forms fo invasive candidiasis. Clinical Infectious Diseases 15 Sep 2007

12.H. W. Hirte, D. Raghunadharao, T. Baetz, S. Hotte, S. Rajappa, A. Iacobucci, S. Sharma, H. Parikh, S. Kulkarni, S. Patil, M. Padigaru, S. Gaston. A phase 1 study of selective cyclin dependent kinase inhibitor P276-00 in patients with advanced refractory neoplasms. 2007 AACR-NCI-EORTC International Conference

2006

1. D. Raghunadharao. Invasive Fungal Infections in the Neutropenic Cancer Patient Abstract cum Souvenir Book, 6th National Conference of SIHAM, Jan 2006. p 54-59

2. D. Raghunadharao. Clinical Trials in Complementary and Alternate Systems of Medicine. 4th International Seminar on Complementary Therapies in Cancer Management. Feb 2006. p 29-32

3. D Nageswararao, S Vishnupriya, D Surekha, K Sailaja and D. Raghunadharao. Genetic Polymorphism of CYP-2D6 and susceptibility to hematological malignancies. International Symposium at the Dept of Genetics, 8-11 Jan 2006

4. D Nageswararao, S Vishnupriya, D Surekha, K Sailaja and D. Raghunadharao Glutathione S Transferase polymorphism in acute leukemias. International symposium on Human Genomics and Public Health & 31 Annual Conference of ISHG. JNU, New Delhi Feb 27- 1 Mar 2006

5. Raghunadharao D, Senthil J Rajappa, Anjna Surath and Srihari Uppalapati. A retrospective analysis of epidemiology and treatment patterns for gastric cancer at a tertiary health care centre in India. ASCO 2006, Atlanta, Abstract 46

6. D. Raghunadharao. Invasive Fungal Infections in the Neutropenic Cancer Patient Abstract cum Souvenir Book, 6th National Conference of SIHAM, Jan 2006. p 54-59

7. D. Raghunadharao. Clinical Trials in Complementary and Alternate Systems of Medicine. 4th International Seminar on Complementary Therapies in Cancer Management. Feb 2006. p 29-32

8. Schlingensiepen, R., Bogdahn U., Mahapatra, A.K., Sasthry, A., Mouli, Ch., Venkataramana, N.K., Sharma, A, Nair, S, Raghunadhrao, D, Parfenov, V., Oliushine, V., Schlingensiepen, K.-H. Antisense Therapy for Recurrent or Refractory Malignant Glioma: Results of a Phase Iib Study. 55th Annual Conference of the Neurological Society of India (December 20th - 23rd 2006, Madurai

9. Senthil Rajappa, Anjna Surath, S. Uppalapati, R. Digumarti. A retrospective analysis of epidemiology and treatment patterns for gastric cancer at a tertiary care center in India. Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition). 24, No 18S (June 20 Supplement), 2006: 4086

2005

1. Lalit Kumar, V P Gangadharan, D. Raghunadharao, Tapan Saikia, Sandip Shah, Hemant Malhotra, P P Bapsy, Kavita Singh, Raman Rao. Nat Med J India 2005; 18 (2):66-70 Safety and efficacy of an indigenous recombinant interferon alpha-2b in patients with chronic myelogenous leukaemia: Results of a multicentre trial from India.

2. Senthil Rajappa, Unni Krishnan, Satish Rao, D. Raghunadharao, Anjna Surath, Aruna Prayaga, Renal metastasis from Primary hepatocellular carcinoma - A case report- Indian Journal of Medical and Pediatric Oncology 2005,Vol 26;No 2:37-39

3. Senthil Rajappa, Anand Loya, Satish Rao, D. Raghunadharao, Anjna Surath, U.Srihari, Metastasis to oral cavity - A report of 2 cases and review of literature, Indian Journal of Medical and Pediatric Oncology 2005, Vol 26;No 2: 43-46

4. Senthil Rajappa, Satish Rao, D. Raghunadharao, Anjna Surath, C. Sundaram, Uma Devi, Melanotic Progonoma – A case report and review of literature Indian Journal of Medical and Pediatric Oncology 2005,Vol 26;No 2: 33-36

5. Senthil Rajappa, Shantveer Uppin, D. Raghunadharao, Anjna Surath, Satish Rao, Isolated Central Nervous system blast crisis in Chronic myeloid leukemia-A case report – Hematological Oncology 2005 published online in Wiley Inter Science (in press)

6. Senthil Rajappa, Sirisha Senthil, D. Raghunadharao. Choroidal metastasis from lung cancer-A case report and review of literature. Indian Journal of Medical and Pediatric oncology 2005 Vol 26,No.3.44-46

7. Senthil Rajappa, D. Raghunadharao, Prabhakar Rao. Avascular necrosis in chronic myeloid leukemia on imatinib mesylate. Hematological Oncology 2005 (under review)

8. D. Raghunadharao, P. Koralewski, P. Servatowski, A Gruszfeld, K Lakshmaiah, A Szczesna, M Savin, K Yen, D Magnuson, A Bhatnagar and M R Green. A randomized phase 2 study of Pivanex and Docetaxel compared to docetaxel monotherapy in patients with previously treated advanced NSCLC. World Conference on Lung Cancer, Barcelona, Spain

9. RT Jacob, Manu Goyal, T Roshni Paul, K Gayathri and D. Raghunadharao. Evaluation of cytognetic and haematological response to therapy in chronic myeloid leukemia. Proceedings of the IX ADNAT and XXX ISHG [Poster O66]

10. D Nageswararao, S Vishnupriya, P Himabindu, AR Poongothai, D Surekha, K Sailaja and D. Raghunadharao. Evaluation of oxidative stress in acute leukemia using MDA assay [Poster O87]. Proceedings of the IX ADNAT and XXX ISHG

11. D Surekha, S Vishnupriya, K Sailaja, D Nageswararao, Poongothai AR, D. Raghunadharao and G Suryanarayanaraju. A case control study of plasma fibrinogen with clinical parameters in breast case. [Poster O88] Proceedings of the IX ADNAT and XXX ISHG

12. K Sailaja, S Visnupriya, Surekha D, D Nagewararao, Poongothai AR and D. Raghunadharao. Effect of clinical variables on Malondialdehyde levels in Chronic Myeloid Leukemia [Poster O98] Proceedings of the IX ADNAT and XXX ISHG

2004

1. Raghunadharao Digumarti, Senthil J Rajappa, A Surat, Lakshmi Srinivas Maddali. A retrospective analysis of the clinical profile and induction outcome for acute myeloid leukemia at a tertiary care centre in a developing country [Poster 607] Proceedings of the ESMO 2004 Vienna, Austria

2. D Surekha, S Vishnupriya, P Himabindu, K Sailaja, Poongothai AR, D. Nageswararao, D. Raghunadharao and G Suryanarayanaraju. Association of Apolipoprotein E Polymorphism with Breast cancer [Poster 36] Proceedings of the International Conference on Human Genome Update. 28-30 August 2004 page 77

3. D. Nageswararao, S Vishnupriya, P Himabindu, S Poongothai, D Surekha, K Sailaja and D Raghunadharao. Quantitative variations of Malondealdehyde levels in acute leukemias. [Poster 38] Proceedings of the International Conference on Human Genome Update. 28-30 August 2004 page 79

4. K Sailaja S Vishnupriya, P Himabindu, Ponngothai AR, Surekha D, D Nageswararao and D Raghunadharao. Study of Fibrinogen levels in chronic myeloid leukemia. [Poster 37] Proceedings of the International Conference on Human Genome Update. 28-30 August 2004 page 78

5. Poongothai AR, Vishnupriya S, Reddy PP and D. Raghunadharao. Variation in spontaneous sister chromatid exchanges in leukeimas: a family study. Proceedings of the International Conference on Human Genome Update. 28-30 August 2004 page 76

6. Sundaram Challa, Aruna Kumari Prayaga, Lakshmi Vemuri, Jaishankar Sadasivan, Murali Krishna Murthy Jagarlapudi, Raghunadharao Digumarti, Rajagopal Prabhala. Fungal Endocarditis: An autopsy study. Asian Cardiovascular and Thoracic Annals 2004; 12: 95-98.

7. Arani Chatterjee, D. Raghunadharao , Rao N V S Mamidi, Kasiram Katneni, Vijay V Upreti, Anjna Surath, Maddali L Srinivas, Srihari Uppalapati, Sangeeta Jiwatani, Swaminathan Subrahmanyam and Nuggehally R Srinivas. Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory cancer patients in a Phase I dose escalation study. J Clin Pharmacol Jul 2004; 44: 723-736.

8. P P Babpsy, D. Raghunadharao, A Majumdar, S Ganguly, A Roy, G Uppal, R Mukherjee, A Burman, N Saha. DO/NDR/02 A novel polymeric nanoparticle paclitaxel: Results of a phase I dose

escalation study. Abstract No: 2026. ASCO 2004. Proc Am Soc Clin Oncol Annual Meeting. Category: Developmental Therapeutics Sub-category – Cytotoxic Chemotherapy Pharmacology/Pharmacokinetics.

9. D. Raghunadharao, Doval DC, Majumdar A, Raoy A, Ganguly S, Uppal G, Mukherjee R, Burman A R, Saha N. Phase I dose escalation study on DRF 7295: A novel peptide based anticancer drug, in patients with advanced, metastatic adenocarcinomas: Final results. Abstract No: 3094. ASCO 2004. Annual Meeting. Category: Developmental Therapeutics – Molecular Therapeutics. Sub-category: Antiangiogenic or antimetastatic agents

10. D. Raghunadharao. Guidelines for the use of tumor markers. Physicians Digest. Vol 13 (1) April-May 2004: 54-62

2003

1. L. Y. Dirix, J. Ignacio, S. Nag, P. Bapsy, H. Gomez, D. Raghunadharao, R. Paridaens, S. Jones, S. Falcon, G. Massimini, for the Exemestane and Celecoxib Study Group Final results from an open-label, multicenter, controlled study of exemestane +/- celecoxib in postmenopausal women with advanced breast cancer (ABC) progressed on tamoxifen (T). Abstract No: 77. Proc Am Soc Clin Oncol 22: page 20, 2003 (abstr 77).

2. R Digumarti, Gangadharan V P, T Saikia, S Shah, L Kumar, H Malhotra, P B Padmanabhan, K Singh. Pichia pastoris derived human recombinant interferon alpha 2b in chronic myeloid leukemia patients: results of a phase 3 multicentric trial. Abstract no.: 735, Proc Am Soc Clin Oncol 2003: Page 183

2002

1. D Raghunadharao. Cytogenetic Profile of Chronic Myeloid Leukemias. Ind J of Cancer Vol 39 (Jun 2002): 61-65.

2. D. Raghunadharao. Clinical trial documentation and Follow-up in Indian setting. Medicine Update 2002 Proceedings of APICON 2002. Vol 12, 1345-6.

3. Raghunadharao D & Sudhavani Tummala. MALT Lymphoma of thyroid. JAPI 50, 2002.

4. A randomised multicentre comparative study of Peginterferon alfa-2a (40 KD) versus interferon alfa-2a in patients with treatment-naïve chronic myelogenous leukaemia. Proceedings of American Society of Hematology Annual Conference. Poster presentation. 2002.

5. Fungal Endocarditis – an autopsy study. Asian Cardiovascular and Thoracic Annals. 2002

6. Promyelocytic Leukemias – clinical, morphological and cytogenetic profile. Proceedings of IAPM AP Chapter 2002. Oral Presentation. Gold Medal for Best Paper.

7. Post radiation sarcomas -a presentation of 3 cases. Proceedings of AROI 2002. Poster Presentation.

8. Acute myeloid Leukemia after Breast cancer: an increased risk or effect of therapy? Proceedings of ISO/ISMPO 2002. Poster Presentation.

9. A Phase 2 study of nano-particle paclitaxel in metastatic breast cancer. Proceedings of ASCO 2002. Poster presentation.

10. A Phase 2 study of Farnesyl transferase inhibitor in relapse, resistant acute myeloid leukemia. Proceedings of ASCO 2002. Poster Presentation.

11. A Phase 1 study of a DRF 1042, a novel orally effective Camptothecin analogue. Proceedings of ASCO 2002. Poster presentation.

2001 1. Spectrum of monoclonal gammopathies in Andhra Pradesh. Ind J Clin Biochem 2001, 16 (1), 52- 59.

2. Cytology of extramedullary myeloid cell tumours (EMCTs). Proceedings of the Indian Association of Cytopathologists. 31st Annual Conference. 2001

3. Cytogenetic response to Interferon in Chronic Myeloid Leukemia: A common denominator of treatment outcome. J Tumor Marker Oncology 2001 14 (4): 359-360

20001. Marrow Mesenchymal Stem Cells. Editorial in Clin Proc NIMS, Vol. 15 (2) Sept. 2000 p 1-3.

1999

Co-authored a chapter entitled Monitoring and Follow-up of patients treated with chemotherapy for ovarian cancer in 'Effective Management of Ovarian Cancer' Edited by A B MacLean, Published by the Royal College of Obstetricians & Gynaecologists, London, UK.

1. Retrospective analysis of ALL: Prognostic features and role of less intensive short term chemotherapy Dec 1999 Proceedings of Asia Pacific Cancer Congress, Chennai.

2. Mitoxanterone induction in acute myeloid leukemia, NIMS experience-7 years study. Dec 1999 Proceedings of Asia Pacific Cancer Congress, Chennai.

3. Clinical profile, treatment and outcome of gestational trophoblastic disease in a tertiary care center. Dec 1999 Proceedings of Asia Pacific Cancer Congress, Chennai.

1998

1. Analysis of Data of the Tumor Registry. Clin Proc NIMS 1998; 13:12-18

2. Squamous Cell Carcinoma of the Scalp with Lung Metastases - A Case Report. Clin Proc NIMS1998; 13: 33-34

3. Management of Malignancies of Haemopoietic System. Chapter in Musculoskeletal System - Imaging and Management. Published by the Nizam's Institute of Medical Sciences, Hyderabad. Pages 173-178.

4. Role of biochemical and cytogenetic markers in acute leukemias. Oral Presentation. 8th Asia Pacific Conference of Clinical Biochemistry.

1997

1. Familial Mosaic Turner’s Syndrome in Siblings with Ovarian Malignancy – a Case Report. Clin Proc NIMS 1997, 12(2): 41-42.

2. Nephrotic Syndrome with Chronic Myeloid Leukemia. Clin Proc NIMS 1997, 12(1): 43-44.

3. Chromosomal Abnormalities in Acute Non-Lymphoblastic leukemia. Clin Proc NIMS, 1997, 7 (3): 12-15.

4. Role of Radiation Therapy in Thymomas -NIMS Experience and Review of literature. Clin Proc NIMS, 1997, 7 (3): 16-18.

5. An Effective and Affordable Chemotherapy Protocol for Hodgkin’s Disease. Clin Proc NIMS 1997, 12(4): 7-8.

6. All-Trans Retinoic Acid - Drug Profile and NIMS Experience. Clin Proc NIMS 1997, 12 (4) 9-11.

7. 5-Fluorouracil Induced Encephalopathy - A Case Report. Clin Proc NIMS1997, 12(4): 25.

1996

1. Sickle beta thalesemia with AML-M4 and orbital chloromas. IJMPO 1996, 17:107-110.

2. Hodgkin’s disease with atypical mycobacteriosis. Clin Proc NIMS 1996, 11(1): 57-58.

3. Carcinoma Breast with submandibular lymphnode metastases. Clin Proc NIMS 1996,11(1): 59-60.

4. Chemotherapy of retinoblastoma. Clin Proc NIMS 1996; 11(3): 5-7

1995

1. Management of drug resistant CML in blast crisis with homeopathic drugs. J Assoc Homeopath Ind.

1994

1. Tumor lysis syndrome. Clin Proc NIMS 1994, 9(4): 62-64.

2. Spinal extradural tumor metastasizing intradurally. Neurol Ind. 1994, 42: 237-238.

3. Chemoprevention. Clin Proc NIMS 1994; 9(2):614. Carcinoma Breast - Choroidal Metastases. Clin Proc NIMS 1994; 9 (4):

36-37.5. Familial Breast Cancer. Clin Proc NIMS 1994; 9(2): 526. Prevalence of Hepatitits C Virus in Liver Diseases and other High Risk

Groups. Clin Proc NIMS 1994; 9(3): 40-42.

1990

1. Importance of serum alpha-fetoprotein in a case of primary mediastinal germ cell tumor (teratoma). Clin Proc NIMS 1990, 5(1): 52-55.

1989

1. Intrathecal methotrexate toxicity. JAPI 1989, 37:5.

1987

1. INH induced antinuclear antibodies. JAPI 1987, 35: 113-115.