rapid and uncontrollable development and production of cells
TRANSCRIPT
Rapid and uncontrollable development and production of cells.
1. Inheritance may increase risk2. Proto-oncogenes and tumor suppressor
genes mutate or become damaged by carcinogens
3. Known carcinogens:• Viruses and bacteria• Environmental chemicals• Tobacco• Radiation• Dietary factors
Conversion begins with a mutation (a change in DNA) by:
1. Chemical2. Physical3. Biological
Conversion
Development and Progression
• Begins when a chemical substance stimulates growth of a mutated cell
• Those chemical substances influence a 2nd stage of carcinogens called promoters.
• Promoters stimulate cell to divide uncontrollably
• Metastasis- cancer traveling to other sites; like a forest fire
ozone
Ozone
• Screens out 99% of harmful UV light• Ozone produced by lightening• 1% in ozone will result in a 2% in
skin cancer
Holes in ozone:
Dupont- CFCs: hairspray, refrigerators,
air conditioning
Which country has the highest rate of
skin cancer?
CFC’s and Ozone Depletion
Sept 2011
Antarctica
Sunburn
Both UVA and UVB are responsible for photoaging and sunburn.
Tanning beds produce both UVA and UVB rays
Strong melanoma candidate
Melanoma facts
From 1996 to 2000, the national average rate for melanoma was 17.5 for every 100,000 people, while the state of Hawaii average was 15.1 cases per 100,000.
• Fair skin or freckles.• Being male.• Family or personal history of
melanoma.• Chronic UV light exposure. • Severe sunburns. • Unusual moles or a large number
of moles.• Weak immune system.
Factors that may also influence the chance of getting melanoma include
ABCDE’s of Skin Cancer
• Genetic testing• Biopsy • Blood test• X-rays, PET, MRI• Visual & tactile observation
• Surgery• Radiation• Chemotherapy• Homeopathy
• Know family history• Get regular medical screenings• Learn self-exam techniques• Avoid direct sunlight• Watch your diet and weight• Don’t smoke• Drink alcohol in moderation (alcohol
decrease heart disease, but increases risk of certain cancers)
• Become educated
Cells provided:• Polio vaccine• research into cancer• AIDS• effects of radiation• Effects of toxic substances• gene mapping
Cervical Cancer
Chromosomes: 82• four copies of chromosome
12 • three copies of chromosomes
6, 8, and 17
http://www.cbsnews.com/8301-205_162-57597182/lacks-family-nih-reach-agreement-on-hela-cell-genome-data/
Cervical Cancer Vaccine Controversy
Michelle BachmannBashes HPV vaccine
http://www.npr.org/blogs/health/2011/09/13/140445104/pediatricians-fact-check-bachmanns-bashing-of-hpv-vaccine
Gardasil Vaccine
INQUIRY
1. What do CFC’s do?2. What is a proto-oncogene?3. Name 3 carcinogens.4. What are the ABCD’s of skin cancer?5. What is the function of ozone?6. Who is Henrietta Lacks?