rapid scar-free wound healing in the ctenophore mnemiopsis

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Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis Mnemiopsis leidyi Matthew B. Dodson* and Anthony G. Moss Auburn University, Cellular & Molecular Biosciences Program Center for Environmental & Cellular Signal Transduction

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Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis. Matthew B. Dodson* and Anthony G. Moss Auburn University, Cellular & Molecular Biosciences Program Center for Environmental & Cellular Signal Transduction. Mnemiopsis leidyi. 1mm. - PowerPoint PPT Presentation

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Page 1: Rapid Scar-Free Wound Healing   in the Ctenophore  Mnemiopsis

Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis

Rapid Scar-Free Wound Healing in the Ctenophore Mnemiopsis

Mnemiopsis leidyi

Matthew B. Dodson* and Anthony G. Moss Auburn University, Cellular & Molecular Biosciences Program

Center for Environmental & Cellular Signal Transduction

Page 2: Rapid Scar-Free Wound Healing   in the Ctenophore  Mnemiopsis

The MechanismThe Mechanism• Wound repair begins within 5 minutes.• Millions of cells migrate to damaged site.• Cells aggregate and pull wound edges together.• Wound heals in 30 minutes without scar.

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1mm

Page 3: Rapid Scar-Free Wound Healing   in the Ctenophore  Mnemiopsis

Cell CulturesCell Cultures• Wound cells can be cultured.• Form new tissue.• Mimic natural conditions.• Easy to manipulate.

100µm

Page 4: Rapid Scar-Free Wound Healing   in the Ctenophore  Mnemiopsis

ImplicationsImplications• Model system to study rapid, scar-free wound repair.• Like fetal wound repair.• Molecular genetic tools allow comparison to humans.• Biomedical discovery tool.

Thanks to:• Alabama Commission on Higher Education and the ACHE-GRSP program.• Auburn University Cellular & Molecular Biosciences Program / Center for Environmental & Cellular Signal Transduction (AU-CMB/CECST).• Alabama EPSCoR and NSF support under Grant No. EPS-0447675 to the CECST and MCB-0348327 to Dr. A.G. Moss (AU-CMB/CECST, Biological Sciences)