rare cancers treatment: the challenges · rare cancers treatment: the challenges the surgeon’s...
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RARE CANCERS TREATMENT:
THE CHALLENGES
The surgeon’s perspective
Sergio Sandrucci, MDVisceral Sarcoma and Rare Cancers Unit
Città della Salute e della Scienza
Turin University Medical School, Turin, Italy
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no potential or actual conflicts of interest
to declare
Conflict of Interest Disclosure
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RARE CANCERS CHALLENGES
ACCESS TO NEW THERAPIES
INEQUALITIES
EARLY AND CORRECT DIAGNOSIS
CLINICAL EXPERTISE
RESEARCH
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surgery the mainstay of treatment of solid
rare tumors(11 out of 12 families)
➢ 2 patients out of 3 can be treated by surgery alone
➢ 30% more can receive a a combined treatment of
radio/chemotherapy and surgery
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Gatta G, et al., Epidemiology of rare cancers and inequalities in oncologic outcomes, Eur J Surg Oncol (2017)
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RPS SARCOMAS MULTIORGAN DISSECTIONEXTREMITY SARCOMAS LIMB SPARING SURGERYTESTICULAR CANCERS NERVE SPARING LYMPHADENECTOMYH&N FUNCTION SPARING SURGERYGISTs ORGAN SPARING SURGERYNETs CURATIVE/PALLIATIVE SURGERY
TRANSPLANT SURGERY
PATHOLOGIC DIAGNOSIS
SURGERY OF METASTASES
NEOADJUVANT TREATMENTS
ADJUVANT TREATMENTS
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SURGEON CHALLENGES
Volume
Expertise in organ surgeryKnowledge of the biology of
the disease
Need for multidisciplinarity
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multidisciplinarity
Referral (dedicated) Centers
Volume
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Study on 12543 patients
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LRFS
RFS
MDT beforesurgery
MDT aftersurgery
MDT beforesurgery
MDT aftersurgery
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there can be profound implications for a patient not diagnosed at a
sarcoma centre, such as missing the chance of a timely diagnosis of a
potentially curable disease, and being spared more extensive surgery
The experience of the surgeon is a prognostic factor of overall
survival in STS
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• Must perform almost 50 sarcoma surgeries/year
• Must act within a multidisciplinary environment
• Must be able to coordinate collaborations when necessary (with a
multidisciplinary surgical team) with the potential for local control
weighted against the potential for long-term dysfunction
the experienced sarcoma surgeon
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2762 patients:
greater propensity for neoadjuvant treatments at ACCs compared with CCCs
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Patients treated at high-volume centers has
1.9-fold higher odds of undergoing surgical management (P < 0.001),
2.5-fold higher odds of receiving a R0/R1 resection (P = 0.026),
1.8-fold higher odds of an R0 resection (P < 0.001).
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A) surgical treatment (red) versus
non surgical treatment (blue)
B) R0/R1 resection
(red) versus R2 resection (blue)
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LOW VOLUME
HIGH VOLUME
POPULATION SURVIVING IN
SEMINOMA
NON SEMINOMA GERM CELL TUMOR
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In surgical area, it will be important the definition of
the minimum number of surgical operations for HNC to be considered
“credentialed” for this disease.
if performance is about practice, competence is a broader field, encompassing
technical expertise, medical knowledge, and ability to judge and to make decisions.
So, the process of credentialing should encounter also these aspects in a more
complex and articulate judgment
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high volume surgeons multidisciplinary team
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In which way the expertise of a centre can be
recognized ?
ONCOPOLICY INSTITUTIONAL
ACCREDITATION PROCESS
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Improving the quality of rare/complex cancer care requires to concentrate expertise
and sophisticated infrastructure in reference centres.
The foundamental step is the translation of the recommendations into policy
decisions: the best interest of the patient should prevail
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32
A MULTI-STAKEHOLDER PARTNERSHIP
INITIATIVE
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CENTRALIZATION IMPROVES OUTCOMES?
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Potential criticism to a “referral centers”
policy
delay induced by centralization and time to
refer the patients
low quality of decision-making in
multidisciplinary meetings due to the vastly
increased numbers of cases needing review
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networking between centers of advanced
treatment and surroundings hospitals is a key
element to ensure that expertise travels, rather
than patients.
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ERN
Sub-
networks
COLLABORATIVE RARE CANCER NETWORKS
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diagnosis Reference center
Treatment plan
Complex surgery
Complex phisical treatments
Less complex treatments
Network and functional relationship
Peripheralcenters
Follow -up
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crucial instruments to improve quality of
surgical care for patients with rare cancers:
research
accrual in multicentric
clinical trials, assuring data
quality control
the low number of patients in rare cancers makes it
difficult to build a comprehensive evidence-base for
practice
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Defining high quality centers and a network of care
by a process of accreditation
a collaborative effort among disease thought-
leaders, politicians, advocates and scientific
societies.
RARE CANCERS TREATMENT: THE CHALLENGES FROM THE SURGEON’S PERSPECTIVE
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In addition to regional expert centers,
smaller local centers must be
identified to deliver less complex care
Sub-networking or integrated
networks
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integrated networks increase
accessibility and minimize the
burden of traveling long distances
low access to proper treatments is likely higher in
underserved areas
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Struggle to inequalities: well-structured
training programs by high quality centers
creation of expert centers in underserved
geographic areas
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• To improve patients’ knowledge and ability
to take decisions
• To secure access to innovative or complex
treatments
• To support research, such as by being
involved in the design of clinical trials
• To advocate at national health policy level.
Actively involve patient advocacies
RARE CANCERS TREATMENT: THE CHALLENGES FROM THE SURGEON’S PERSPECTIVE